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Kisel, Andrej. "Person Identification by Fingerprints and Voice". Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2010. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2010~D_20101230_093643-05320.
Pełny tekst źródłaPenkiose disertacijos darbo dalyse nagrinėjamos žmogaus identifikavimo pagal pirštų atspaudus ir balsą problemos ir siūlomi jų sprendimai. Pirštų atspaudų požymių išskyrimo algoritmų kokybės įvertinimo problemą siūloma spręsti panaudojant sintezuotus pirštų atspaudus. Darbe siūlomos žinomo pirštų atpaudų sintezės algoritmo modifikacijos, kurios leidžia sukurti piršto atspaudo vaizdą su iš anksto nustatytomis charakteristikomis ir požymiais bei pagreitina sintezės procesą. Pirštų atspaudų požymių palyginimo problemos yra aptartos ir naujas palyginimo algoritmas yra siūlomas deformuotų pirštų palyginimui. Algoritmo kokybė yra įvertinta ant viešai prieinamų ir vidinių duomenų bazių. Naujas asmens identifikavimo pagal balsą metodas remiantis tiesinės prognozės modelio grupinės delsos požymiais ir tų požymių palyginimo metrika kokybės prasme lenkia tradicinius asmens identifikavimo pagal balsą metodus. Pirštų ir balso įrašų nepriklausomumas yra irodytas ir asmens atpažinimas pagal balsą ir pirštų atspaudus kartu yra pasiūlytas siekiant išspręsti bendras biometrinių sistemų problemas.
Gudnason, Jon. "Voice source cepstrum processing for speaker identification". Thesis, Imperial College London, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.439448.
Pełny tekst źródłaIliadi, Konstantina. "Bio-inspired voice recognition for speaker identification". Thesis, University of Southampton, 2016. https://eprints.soton.ac.uk/413949/.
Pełny tekst źródłaHaider, Zargham. "Robust speaker identification against computer aided voice impersonation". Thesis, University of Surrey, 2011. http://epubs.surrey.ac.uk/770387/.
Pełny tekst źródłaAtkinson, Nathan. "Variable factors affecting voice identification in forensic contexts". Thesis, University of York, 2015. http://etheses.whiterose.ac.uk/13013/.
Pełny tekst źródłaFredrickson, Steven Eric. "Neural networks for speaker identification". Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294364.
Pełny tekst źródłaGillivan-Murphy, Patricia. "Voice tremor in Parkinson's disease (PD) : identification, characterisation and relationship with speech, voice and disease variables". Thesis, University of Newcastle upon Tyne, 2013. http://hdl.handle.net/10443/2170.
Pełny tekst źródłaWildermoth, Brett Richard, i n/a. "Text-Independent Speaker Recognition Using Source Based Features". Griffith University. School of Microelectronic Engineering, 2001. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20040831.115646.
Pełny tekst źródłaWildermoth, Brett Richard. "Text-Independent Speaker Recognition Using Source Based Features". Thesis, Griffith University, 2001. http://hdl.handle.net/10072/366289.
Pełny tekst źródłaThesis (Masters)
Master of Philosophy (MPhil)
School of Microelectronic Engineering
Faculty of Engineering and Information Technology
Full Text
Rouse, Kenneth Arthur Gilbert Juan E. "Classifying speakers using voice biometrics In a multimodal world". Auburn, Ala, 2009. http://hdl.handle.net/10415/1824.
Pełny tekst źródłaAustin, Catherine. "The identification of psychological and social processes involved in Psychogenic Voice Disorder". Thesis, University of East London, 1997. http://roar.uel.ac.uk/3647/.
Pełny tekst źródłaArmstrong, Paul-Alan. "Songs of praxis : reflexive space for authentic teacher voice identification, development and transformation". Thesis, University of Sunderland, 2015. http://sure.sunderland.ac.uk/7336/.
Pełny tekst źródłaRaghunathan, Anusha. "EVALUATION OF INTELLIGIBILITY AND SPEAKER SIMILARITY OF VOICE TRANSFORMATION". UKnowledge, 2011. http://uknowledge.uky.edu/gradschool_theses/101.
Pełny tekst źródłaAkarapu, Deepika. "Object Identification Using Mobile Device for Visually Impaired Person". University of Dayton / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=dayton1628092619349812.
Pełny tekst źródłaSepielak, Katarzyna. "Voice-over in multilingual fiction movies in Poland. Translation and synchronization techniques, content comprehension and language identification". Doctoral thesis, Universitat Autònoma de Barcelona, 2016. http://hdl.handle.net/10803/392684.
Pełny tekst źródłaThis dissertation analyzed voiced-over multilingual movies in Poland. In particular, it focused on different translation and synchronization techniques applied in voiced-over multilingual movies and then shifted its focus to information processing, comprehension and identification of various languages in voiced-over movies. Three main objectives were formulated in this research: 1) To establish how multilingual elements are translated in voiced-over movies into Polish; 2) To establish the relationship between synchronization and translation techniques in multilingual movies voiced-over into Polish and to analyze which combinations of synchronization and translation techniques are most efficient in rendering multilingual context; and 3) To test how multilingual elements are processed by Polish viewers in both voiced-over and subtitled multilingual movies. With those objectives in mind, two descriptive and one experimental studies were carried out. The first study showed that introducing multilingual elements in source texts was a deliberate procedure, which often disappeared in the target text. The analysis of the corpus showed that multilingual elements were significantly reduced in the Polish versions. The analysis revealed that although many translation techniques were detected in utterances with L3 elements, only two techniques—imitation and exhibition—reinforced multilingual content in the translated version. Other techniques, most frequently encountered, just erased linguistic diversity present in the original versions. However, as the original soundtrack in voiced-over movies is still audible to some point, skillful synchronization of the two soundtracks helped in marking multilingual context in the movie. The second study indicated that the relationship between different synchrony types and some translation techniques, mainly condensation, transfer, paraphrase and decimation did exist but each synchrony showed different patterns as to the nature of this relationship. In the case of voice-over isochrony, the relationship was definitely not causal. The standard practice consisted of the voice artists reading the translation after hearing the original utterance with no guidelines specifying the exact number of seconds they should leave before starting reading the translation. Literal synchrony appeared in very few cases. The relationship of this type of synchrony with translation techniques could also be qualified as random Action and kinetic synchronies, on the other hand, were kept in most of the cases and transfer and condensation were the most common techniques that could be related to them. The analysis also revealed that out of four types of synchronies, voice-over isochrony is the only one which actually helped expose multilingual context in the movie. Given its nature, as it exposed the original soundtrack even if for a short amount of time, this synchrony might enhance the linguistic diversity in the movie. This led to the question whether this diversity was in fact processed by viewers, an inquiry that was empirically addressed in the third study. For comparative and controlling reasons, the third study introduced subtitling to the analysis. The results of the experiment showed that content comprehension depended on the audiovisual translation mode, yielding higher levels of performance in the subtitled condition than in the voice-over one. At the same time, the findings suggested that information processing in voiced-over programs was not as efficient as in the subtitled version. Second, the results indicated that the audiovisual translation mode did not predict the performance on detection of the number of languages spoken by character in multilingual productions. Finally, it was concluded that neither the AVT mode nor the multilingual and monolingual characters were significant predictors of character– language pair identification in a multilingual movie.
Dhakal, Parashar. "Novel Architectures for Human Voice and Environmental Sound Recognitionusing Machine Learning Algorithms". University of Toledo / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1531349806743278.
Pełny tekst źródłaShalita, Martin P. "The Operas of Ralph Vaughan Williams: An Identification and Performance Analysis of the Arias and Duet Scenes for Male Voice". Scholarly Repository, 2011. http://scholarlyrepository.miami.edu/oa_dissertations/553.
Pełny tekst źródłaBich, Serhiy [Verfasser], i Detmar [Akademischer Betreuer] Meurers. ""Is There Choice in Non-Native Voice?" Linguistic Feature Engineering and a Variationist Perspective in Automatic Native Language Identification / Serhiy Bich ; Betreuer: Detmar Meurers". Tübingen : Universitätsbibliothek Tübingen, 2017. http://d-nb.info/1167243757/34.
Pełny tekst źródłaTahon, Marie. "Analyse acoustique de la voix émotionnelle de locuteurs lors d’une interaction humain-robot". Thesis, Paris 11, 2012. http://www.theses.fr/2012PA112275/document.
Pełny tekst źródłaThis thesis deals with emotional voices during a human-robot interaction. In a natural interaction, we define at least, four kinds of variabilities: environment (room, microphone); speaker, its physic characteristics (gender, age, voice type) and personality; emotional states; and finally the kind of interaction (game scenario, emergency, everyday life). From audio signals collected in different conditions, we tried to find out, with acoustic features, to overlap speaker and his emotional state characterisation taking into account these variabilities.To find which features are essential and which are to avoid is hard challenge because it needs to work with a high number of variabilities and then to have riche and diverse data to our disposal. The main results are about the collection and the annotation of natural emotional corpora that have been recorded with different kinds of speakers (children, adults, elderly people) in various environments, and about how reliable are acoustic features across the four variabilities. This analysis led to two interesting aspects: the audio characterisation of a corpus and the drawing of a black list of features which vary a lot. Emotions are ust a part of paralinguistic features that are supported by the audio channel, other paralinguistic features have been studied such as personality and stress in the voice. We have also built automatic emotion recognition and speaker characterisation module that we have tested during realistic interactions. An ethic discussion have been driven on our work
GROVES, WRIGHT KATHY J. "ACOUSTICS AND PERCEPTION OF WET VOCAL QUALITY IN IDENTIFYING PENETRATION/ASPIRATION DURING SWALLOWING". University of Cincinnati / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1176987749.
Pełny tekst źródłaViamontes, Quintero Jesika. "A Mixed Method Inquiry into Student Academic Optimism: Validation of the Construct and Its Use to Give Voice to Latinx Student Experiences". Thesis, University of North Texas, 2020. https://digital.library.unt.edu/ark:/67531/metadc1703281/.
Pełny tekst źródłaSanderson, Conrad, i conradsand@ieee org. "Automatic Person Verification Using Speech and Face Information". Griffith University. School of Microelectronic Engineering, 2003. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20030422.105519.
Pełny tekst źródłaVečeřa, Stanislav. "Návrh řešení automatické identifikace v logistickém centru". Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2010. http://www.nusl.cz/ntk/nusl-222560.
Pełny tekst źródłaТодорів, Андрій Дмитрович. "Система багатофакторної аутентифікації користувачів комп’ютерних систем". Master's thesis, КПІ ім. Ігоря Сікорського, 2020. https://ela.kpi.ua/handle/123456789/38366.
Pełny tekst źródłaTopic relevance The solution to the problem of corporate data protection in the XXI century has gone beyond the physical interaction with employees, due to the transition of the required information into a computer format. This feature has formed the need to develop and implement new mechanisms for corporate data protection. The proposed system of authentication of computer system users, developed on the basis of neural network technologies, provides the possibility of user identification on the basis of individual anthropometric visual and voice indicators of the subject, in order to prevent theft of corporate data and identification of criminal entities. The object of study is the transformation of anthropometric indicators into a computer form. The subject of study is the mechanisms of pattern recognition. The goal of this work is to improve the capabilities of biometric identification methods of subjects by developing a new architecture based on neural networks. Study methods. Comparison of existing algorithms on the criteria of accuracy, speed, resource costs, reliability, in order to implement and further modify the corporate control system. The scientific novelty is the development of a new mechanism for identifying subjects that combines algorithms for voice and visual identification of subjects. The practical value lies in the possibility of using this system in a corporate environment in order to prevent data leakage and identification of criminal entities. Low resource consumption contributes to the application of the developed algorithm in highly loaded systems. Structure and scope of work. The master's dissertation consists of an introduction, four chapters, conclusions and appendices. The introduction analyzes the problem of corporate data protection. The prospects of using the mechanisms of biometric voice and visual identification of subjects for its solution are substantiated. Biometric identification algorithms are investigated. The first section describes the existing algorithms for recognizing visual and voice images. The second section investigates the feasibility of using existing algorithms for voice and visual biometric identification, analyzes and compares existing image recognition architectures. The third section describes the process of developing algorithms for visual and voice biometric user identification The fourth section presents the characteristics of the developed COP, the test results, the system is studied on different data sets, and its modification in order to achieve the specified accuracy. The conclusions summarize the results of research and development.
Patino, Villar José María. "Efficient speaker diarization and low-latency speaker spotting". Thesis, Sorbonne université, 2019. http://www.theses.fr/2019SORUS003/document.
Pełny tekst źródłaSpeaker diarization (SD) involves the detection of speakers within an audio stream and the intervals during which each speaker is active, i.e. the determination of ‘who spoken when’. The first part of the work presented in this thesis exploits an approach to speaker modelling involving binary keys (BKs) as a solution to SD. BK modelling is efficient and operates without external training data, as it operates using test data alone. The presented contributions include the extraction of BKs based on multi-resolution spectral analysis, the explicit detection of speaker changes using BKs, as well as SD fusion techniques that combine the benefits of both BK and deep learning based solutions. The SD task is closely linked to that of speaker recognition or detection, which involves the comparison of two speech segments and the determination of whether or not they were uttered by the same speaker. Even if many practical applications require their combination, the two tasks are traditionally tackled independently from each other. The second part of this thesis considers an application where SD and speaker recognition solutions are brought together. The new task, coined low latency speaker spotting (LLSS), involves the rapid detection of known speakers within multi-speaker audio streams. It involves the re-thinking of online diarization and the manner by which diarization and detection sub-systems should best be combined
Sanderson, Conrad. "Automatic Person Verification Using Speech and Face Information". Thesis, Griffith University, 2003. http://hdl.handle.net/10072/367191.
Pełny tekst źródłaThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Microelectronic Engineering
Full Text
Saint-Lu, Nathalie. "Identification et caractérisation de formulations d'allergènes pour l'immunothérapie par voie sublinguale". Paris 11, 2009. http://www.theses.fr/2009PA11T034.
Pełny tekst źródłaKoc, Turgay. "Nonlinear Interactive Source-filter Model For Voiced Speech". Phd thesis, METU, 2012. http://etd.lib.metu.edu.tr/upload/12615159/index.pdf.
Pełny tekst źródłas parameters from only speech signal is a nonlinear blind deconvolution problem. The problem is solved by a robust method developed based on the acoustical interpretation of the systems. Experimental results show that ISFMs produce source-filter coupling effects seen in the physical simulations and the parameter estimation method produce always stable and better performing models than LSFM model. In addition, a framework for the incorporation of the source-filter interaction into classical source-filter model is presented. The Rosenberg source model is extended to an interactive source for voiced speech and its performance is evaluated on a large speech database. The results of the experiments conducted on vowels in the database show that the interactive Rosenberg model is always better than its noninteractive version. In the second part of the thesis, LSFM and ISFMs are compared by using not only the speech signal but also HSV (High Speed Endocopic Video) of vocal folds in a system identification approach. In this case, HSV and speech are used as a reference input-output data for the analysis and comparison of the models. First, a new robust HSV processing algorithm is developed and applied on HSV images to extract the glottal area. Then, system parameters are estimated by using a modified version of the method proposed in the first part. The experimental results show that speech signal can contain some harmonics of the fundamental frequency of the glottal area other than those contained in the glottal area signal. Proposed nonlinear interactive source-filter models can generate harmonics components in speech and produce more realistic speech sounds than LSFM.
Faresse, Nourdine. "Identification de PCTA, un nouvel effecteur de la voie de signalisation du TGF-beta". Paris 6, 2007. http://www.theses.fr/2007PA066428.
Pełny tekst źródłaTriffaux, Emily. "Identification des canaux Cav1 impliqués dans la voie de signalisation calcique des lymphocytes Th2". Toulouse 3, 2013. http://thesesups.ups-tlse.fr/1959/.
Pełny tekst źródłaAsthma is an allergic pulmonary disease which affects around 10% of the population. Allergen-specific type 2 T helper lymphocytes Th2 have a crucial role in the asthma physiopathology by producing interleukin IL4,5,13. Previously, my team reported that mouse Th2 but not Th1 cells express voltage gated calcium CaV1 channels. CaV1 channel specific antisense oligonucleotide CaV1AS inhibit calcium response and Th2 cytokine production (IL4,5,13) upon TCR stimulation without any effect on Th1 cells in mice. In addition, CaV1AS prevent experimental allergic asthma. During my PhD, I showed the CaV1. 4 expression in human resting cells. Conversely, CaV1. 2 and CaV1. 3 predominated in Th2 cells and were lost in Th1 cells. CaV1 channel inhibitors, CaV1. 2 AS and CaVbAS decreased calcium signaling and cytokine production in Th2 but not in Th1 cells. Moreover, CaVbAS decrease the CaV1. 2 protein suggesting that CaVb is required for CaV1. 2 stability in Th2 cells. Finally selective PKCa/b inhibition decreased calcium response and cytokine production by Th2 but not Th1 cells suggesting that PKC may contribute to CaV1 regulation in Th2 cells. These results suggest that the inhibition of CaV1. 2 channels could be beneficial in allergic diseases while sparing Th1 cell responses
Zablocki, Laurent. "Identification de facteurs de régulation de la voie de signalisation TLR3 par crible génétique". Thesis, Sorbonne université, 2018. http://www.theses.fr/2018SORUS533.
Pełny tekst źródłaThe fight of the organism against pathogens involves the detection of molecular patterns that are conserved among pathogens. Among the arsenal of receptors capable of recognizing these patterns, there is the family of endosomal Toll-like receptors (TLRs) that are specific for nucleic acids. Among them, TLR3 senses the abnormal presence of double-stranded RNA in the endosomes and initiates a potent innate immune response. Nevertheless, mechanisms governing TLR3 regulation still remain poorly understood. To identify new molecular players involved in the TLR3 pathway, we performed a genome-wide screen using the CRISPR/Cas9 technology using reporter cells expressing GFP when stimulated via TLR3. Mutagenesis was achieved by transducing these cells with the lentiviral GeCKO v2 sgRNA library. Cells were then subjected to sequential rounds of stimulation with poly(I:C) and sorting of the GFP- cells. Enrichments in sgRNA estimated by deep-sequencing identified genes required for TLR3-induced activation of NF-κB. Five genes, including TLR3 itself and the chaperone UNC93B1, known to be critically involved in the TLR3 pathway, were identified by the screen, thus validating our strategy. We further studied the best 40 hits. Among the hits confirmed, we focused on AhR (aryl hydrocarbon receptor). Depletion of AhR had a dual effect on the TLR3 response, abrogating the IL-8 production and enhancing the IP-10 release. Interestingly, in primary human macrophages exposed to poly(I:C), AhR activation enhanced IL-8 and inhibited the IP-10 one. Overall, AhR appears able to modulate the TLR3 response
Bouvard, Daniel. "Identification d'une voie de signalisation controlant l'adhérence cellulaire dépendante de l'intégrine [alpha]5[bêta]1". Université Joseph Fourier (Grenoble), 1999. http://www.theses.fr/1999GRE10158.
Pełny tekst źródłaKhater, Fida. "Identification et validation fonctionnelle de nouveaux gènes impliqués dans la voie de biosynthèse des composés phénoliques". Thesis, Montpellier, SupAgro, 2011. http://www.theses.fr/2011NSAM0018/document.
Pełny tekst źródłaGrape proanthocyanidins (PA) play a major role in organoleptic properties of wine, being involved in astringency and color stability. They are accumulated mainly in skin and seeds during early stages of berry development. Numerous structural genes involved in PA biosynthesis have already been identified even in grape, but some steps are still not documented.A previous transcriptomic study led to identify new genes putatively involved in the PA pathway (Terrier et al., 2009). Among them, 3 glucosyltransferases and 2 glucose acyl transferases were identified. The objective of this work is to clarify the function of these genes in the phenylpropanoid pathway.The three glucosyltransferases called VvgGT1, VvgGT2, VvgGT3 displayed high sequence similarities between them and with other plant glucosyltransferases able to catalyze the formation of glucose esters. The transcripts are expressed in the early stages of grape berry development, mainly in skins and seeds and also in the pulp for VvgGT2. The properties of these 3 enzymes (Km, Vm, substrate specificity, pH sensitivity) were studied in vitro after production of recombinant proteins. The three of them are able to catalyse the synthesis of glucose ester with derivates of hydroxybenzoic acids and hydroxycinnamic acids as substrates and with similar kinetic properties.Two glucose-acyltransferases called VvGAT1 and VvGAT2 were isolated. They displayed high sequence similarity with other Serine carboxypeptidase like acyltransferases-glucose dependent. The transcripts are expressed in early stages of grape berry development mainly in skins and seeds for VvGAT1 and in pulp and seeds for VvGAT2. Heterologous expression of the proteins in different hosts were unsuccessful. The confocal microscopy data suggest that VvGAT1 fused to GFP are localized in cytosolic vesicles.The successive involvement of those VvgGT and VvGAT in the galloylation of PAs and in the synthesis of hydroxycinnamic esters is discussed
Rondeau, Evelyne. "Identification d'interacteurs moléculaires et génétiques des argonautes impliqués dans la voie des microARN chez C. Elegans". Thesis, Université Laval, 2008. http://www.theses.ulaval.ca/2008/25600/25600.pdf.
Pełny tekst źródłaIn eukaryotes, microRNAs are small non-coding RNAs which have the role of regulating genes essential for development and cellular differentiation. Beside the RNAse III family members (Drosha and Dicer) and the Argonaute proteins ALG-1 and ALG-2 in C. elegans, essential components of this gene regulation pathway are still not uncovered. In order to characterize the implication of Argonaute proteins ALG-1 and ALG-2 in microRNA pathway, we used two approaches. First, we studied the interaction between microRNA and ALG-1 during worm development by microarray analysis of microRNA associated to ALG-1. From this analysis, we observed that the majority, but not the totality, of microRNA are associated to ALG-1, mostly at early developmental stages. Secondly, to identify new components of microRNA pathway, we conducted a genetic screen to identify new interactors of alg-2. Our screen is based on the synthetic lethality feature of alg-2 and alg-1 genes. In absence of both genes, the animal can not survive. With this synthetic lethal screen, we want to identify new genes that work in synergy with alg-2, like alg-1, interacting in the same genetic pathway. The worms have been mutagenized and 11 mutants, classified in 5 complementation groups, have been collected. By using various mapping techniques, we localized the mutation on mutant sla-1(qbc1) on chromosome V, between the genetic positions of -12.7 and -3.65.
Saraswathy, Vishnu. "Identification d’un nouveau rôle de la E3-ubiquitin ligase Mindbomb1 dans la voie Polarité Cellulaire Planaire". Electronic Thesis or Diss., Université Côte d'Azur (ComUE), 2019. http://theses.univ-cotedazur.fr/2019AZUR6000.
Pełny tekst źródłaDuring my PhD, I studied two different cell signaling pathways that regulate morphogenesis during zebrafish development. I found that the Notch signaling pathway and Mib1 mediated Planar Cell Polarity (PCP) pathway regulate neural tube morphogenesis and embryonic axis extension respectively.During the first part of my PhD, I addressed the role of Notch signaling in zebrafish neural tube morphogenesis. Notch signaling has been well studied for its role in regulating neurogenesis during zebrafish development. However, whether and how it regulates morphogenesis of the zebrafish neural tube is unknown. Epithelialization and c-division are important events during zebrafish neural tube morphogenesis. Our findings show that, in addition to regulating the timing and identity of neuronal cell fate specification, Notch mediated suppression of neurogenesis is essential for the acquisition of polarized neuroepithelial tissue architecture and the execution specific morphogenetic movements called c-divisions, in order to properly shape the zebrafish spinal cord. Observations from the first part of my PhD led to the identification of the role of Mindbomb1(Mib1) in PCP signaling. Mib1, an E3-ubiquitin ligase required for Notch activation, regulates convergent extension (CE) movements during zebrafish gastrulation, that are required for the axis elongation of the embryo. Interestingly, I found that Mib1, independent of its function in Notch signaling, act in the PCP pathway to regulate axis extension. In the PCP pathway, Mib1 acts as an E3-ubiquitin ligase and regulates endocytosis of the PCP component Ryk to mediate CE during gastrulation. Thus, my study discovered that independent of its role in Delta/Notch signaling, Mib1 is important for the PCP pathway during zebrafish gastrulation
Mekyska, Jiří. "Identifikace osob pomocí otisku hlasu". Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2010. http://www.nusl.cz/ntk/nusl-218235.
Pełny tekst źródłaHichri, Imène. "Identification et caractérisation fonctionnelle de gènes régulateurs de la voie de biosynthèse des flavonoïdes chez la Vigne". Thesis, Bordeaux 1, 2009. http://www.theses.fr/2009BOR13875/document.
Pełny tekst źródłaPhenolic compounds, and more specifically flavonoids (flavonols, condensed tannins and anthocyanins), are key components of the grapevine and wine quality. Because of their antioxidant activities, these compounds are of interest in pharmacological and cosmetic industries, as well as being beneficial to the human diet. Previous work on model plants showed that the flavonoid pathway was mainly regulated by the MYB and bHLH transcription factors, and WD40 proteins. In the grapevine (Vitis vinifera L.), only MYB regulators have been identified until now, and no bHLH or WD40 have been characterised. In this work, several approaches were used to identify new transcription factors involved in grapevine flavonoid biosynthesis. Firstly, the VvMYB5b protein was used as a bait in a large scale two hybrid experiment in yeast (Saccharomyces cerevisiae). Secondly, the promoter of the VvDFR gene, coding a central enzyme of the flavonoid pathway, was chosen to conduct a large scale one hybrid experiment, also in yeast. Finally, a “gene candidate” approach allowed identification of the bHLH transcription factors VvMYC1 and VvMYCA1. VvMYCA1 expression profile in berry skin and seeds correlates with condensed tannins synthesis, whereas VvMYC1 transcript accumulation in these tissues and the grapevine inflorescence correlates with condensed tannins, anthocyanins and flavonols accumulation. In yeast, VvMYC1 could physically interact with different MYB partners regulating the anthocyanin or the condensed tannins biosynthesis. This interaction was confirmed by transient promoter assays in grape cell suspensions, where co-expression of VvMYC1 with specific MYB partners activated the UFGT and ANR promoters. Likewise, this interaction induced anthocyanin accumulation in grape cells, as well as in tobacco leaves and Arabidopsis. Eventually, additional transient promoter assays revealed that VvMYC1 is involved, with VvMYBPA1, in feedback regulation of its own expression
Khatami, Iman. "Free-field inlet / outlet noise identification on aircraft engines using microphones array". Thèse, Université de Sherbrooke, 2014. http://hdl.handle.net/11143/7581.
Pełny tekst źródłaRésumé : La présente thèse étudie la discrimination du bruit d'entrée / de sortie des moteurs d'avion dans des tests statiques en champ libre en utilisant des antennes de microphones en champ lointain. Diverses techniques sont comparées pour ce problème, dont la formation de voie classique (CB), la méthode inverse régularisée (régularisation de Tikhonov), la formation de voies généralisée inverse (L1-GIB), Clean-PSF, Clean-SC et deux méthodes proposées qui s'appellent la méthode hybride et la méthode Clean-hybride. La méthode la formation de voie classique est désavantagée en raison de son besoin de nombreux microphones de mesure. De même, la méthode inverse est désavantagée en raison du besoin d'information a priori sur les sources. La régularisation Tikhonov classique fournit des améliorations dans. la stabilité de la solution; cependant elle reste désavantageuse en raison de son exigence d'imposer une pénalité plus forte pour des positions de source non détectées. Des sources cohérentes et incohérentes peuvent être résolues par la formation de voies généralisée inverse (L1-GIB). Cet algorithme peut identifier les sources multi- polaires aussi bien que les sources monopolaires. Cependant, l'identification de source par la formation de voies généralisée inverse prend beaucoup de temps et exige un ordinateur avec une capacité de mémoire élevée. La méthode hybride est une nouvelle méthode de régularisation qui implique l'utilisation d'un traitement par formation de voie a priori pour définir une norme discrète et dépendante des données pour la régularisation du problème inverse. En comparaison avec la formation de voie classique et la méthode inverse, l'approche hybride (régularisation par formation de voie) fournit des cartographies améliorées d'amplitudes de sources sans aucune complexité supplémentaire substantielle. Bien que la méthode hybride lève les limitations des méthodes classiques, l'application de cette méthode pour l'identification de sources de faible puissance en présence de sources de forte puissance n'est pas satisfaisante. On peut expliquer ceci par la plus grande pénalisation appliquée à la source plus faible dans la méthode hybride, qui aboutit à la sous-estimation de l'amplitude de cette source. Pour surmonter ce défaut, la méthode Clean-SC et la méthode Clean-hybrides proposée qui est une combinaison de la méthode hybride et de Clean-SC sont appliquées. Ces méthodes éliminent l'effet des sources fortes dans les cartographies de puissance de sources pour identifier les sources plus faibles. Les méthodes proposées qui représentent la contribution principale de cette thèse conduisent à des résultats fiables et ouvrent des nouvelles voies de recherche. L'étude théorique de toutes les approches est menée pour divers types de sources et de configurations microphoniques. Pour valider l'étude théorique, plusieurs expériences en laboratoire sont réalisées à Université de Sherbrooke. Les méthodes proposées ont été appliquées aux données de bruit mesurées d'une turbo-soufflante Pratt & Whitney Canada pour fournir une meilleure résolution spatiale des sources acoustique et une solution robuste avec un nombre limité des microphones de mesure comparé aux méthodes existantes.
Giguère, Nellie. "Identification de partenaires potentiels de la protéine ALG-1 : découverte de nouveau joueurs dans la voie des microARNs". Thesis, Université Laval, 2011. http://www.theses.ulaval.ca/2011/27755/27755.pdf.
Pełny tekst źródłaGinis, Olivia. "Identification de facteurs de transcription régulateurs de la voie de biosynthèse des alcaloïdes indoliques monoterpéniques chez Catharanthus roseus". Thesis, Tours, 2012. http://www.theses.fr/2012TOUR4014/document.
Pełny tekst źródłaCatharanthus roseus is a tropical plant producing specifically monoterpene indole alkaloids (MIA) of high interest due to their therapeutical values. In C. roseus cells, the terpenoid branch including the methyl erythritol phosphate pathway (MEP) provides the MIA terpenoid moiety and is regarded as limited for MIA biosynthesis. This branch presents a coordinated transcriptional regulation in response to hormonal signals leading to MIA production. In this context, bioinformatic analysises and functional characterization of MEP pathway gene promoters allowed the identification of new transcription factor families involved in the MIA pathway regulation. Members of ZCT proteins, WRKY and type B RR families specifically interact with the hds promoter from the MEP pathway and regulate its activity. This work permits to gain into insight the transcriptional network controlling the MIA biosynthesis. It is possible now to consider using transcription factor that act as activators and target genes from the terpenoid branch to increase the accumulation of alkaloids of pharmaceutical interest in C. roseus by metabolic engineering approaches
Vatinel, Sébastien. "Identification de nouveaux partenaires du récepteur CCK2 : rôle de la phosphophatase SHP2 dans l'activation de la voie Akt". Toulouse 3, 2006. http://www.theses.fr/2006TOU30215.
Pełny tekst źródłaBelzacq, Anne-Sophie. "La voie mitochondriale de l'apoptose, identification d'une nouvelle cible thérapeutique potentielle : le translocateur de nucléotides à adénine (ANT)". Compiègne, 2002. http://www.theses.fr/2002COMP1408.
Pełny tekst źródłaVialart, Guilhem. "Identification et caractérisation fonctionnelle de gènes impliqués dans la voie de biosynthèse des furocoumarines chez les végétaux supérieurs". Thesis, Université de Lorraine, 2012. http://www.theses.fr/2012LORR0390/document.
Pełny tekst źródłaFuranocoumarins are secondary metabolites deriving from the phenylpropanoid biosynthetic pathway. These phytoalexins are especially involved in plant defense mechanisms against insects or phytopatogenous fungi and bacteria. The molecular control of this biosynthetic pathway is still poorly understood even though it has been demonstrated since the 1960s that enzymes catalyzing the different steps are belonging to different enzymatic families. The work presented here is focused on two enzyme families: oxoglutarate dependent dioxygenases and cytochrome P450s. The first step in the furanocoumarins biosynthetic pathway is the ortho-hydroxylation of p-coumarate, which leads to the formation of umbelliferone. Based on a recent work done on Arabidopsis, we isolated six genes encoding dioxygenases from Ruta graveolens, Citrus limetta and Pastinaca sativa. The corresponding proteins share more than 58% identity with the A. thaliana féruloyle 6' Hydroxylase (F6'H). The functional characterization of these enzymes was performed in a prokaryotic heterologous expression system. Of the six enzymes, three could not be functionnaly expressed and two exhibited a similar F6'H activity as described for A. thaliana. The last enzyme has new properties not described to date. It is able to achieve both hydroxylation of féruloyle CoA and p-coumaroyle CoA. These in vitro studies were completed by a functional exploration of the protein in planta. A detailed analysis of the gene expression pattern highlighted a link with the level of umbelliferone synthesis. The function of the protein was also confirmed by an analysis of the products formed in transiently transformed Nicotiana benthamiana leaves. Cytochrome P450s catalyze 60% of the reactions of the furanocoumarin biosynthetic pathway. Therefore, a functional screening of cytochrome P450 previously identified in Ammi majus and Thapsia garganica was undertaken. The bioinformatic analyses and the changes undertaken in the procedure for expression in yeast allowed drawing hypotheses on the function of some of these P450 candidates. These exploratory and preliminary experiments allowed suggesting new hypotheses about the biosynthetic pathway
Savarin, Julie. "Caractérisation de la voie TCTP (TRANSLATIONALLY CONTROLLED TUMOR PROTEIN) chez Arabidopsis thaliana : identification des régulateurs de son accumulation et importance de la voie au cours du développement embryonnaire". Thesis, Lyon, 2018. http://www.theses.fr/2018LYSEN001.
Pełny tekst źródłaTCTP (Translationally Controlled Tumor Protein) is strongly conserved among eukaryotes. It is a vital protein implicated in various major processes, and its absence leads to early embryolethality in many organisms. In plants as in animals, TCTP is a key factor of growth and development. Implicated in apoptosis and DNA repair, TCTP is also an enhancer of cell proliferation, and is a key element of tumorigenesis. Major functions of TCTP are conserved between plants and animals, but upstream factors are not known yet. Using a genetic screen on the model plant Arabidopsis thaliana, the principal goal of this thesis was to discover regulators of TCTP.In parallel, the impact of TCTP knockout on auxin and cytokinin pathways during embryo development was investigated
Abdouni, Abdejabbarl. "Ouverture et croissance économique dans les pays en voie de développement : Contribution théorique et identification des liens empiriques à l'aide de l'économétrie des données de panel". Aix-Marseille 2, 2003. http://www.theses.fr/2003AIX24013.
Pełny tekst źródłaChaveroux, Cédric. "Identification d'une nouvelle voie de signalisation impliquée dans la régulation des gènes par les acides aminés, chez les mammifères". Phd thesis, Université d'Auvergne - Clermont-Ferrand I, 2009. http://tel.archives-ouvertes.fr/tel-00726314.
Pełny tekst źródłaMelis, Nicolas. "Identification de deux nouvelles cibles dans la gestion du stress oxydatif ; la protéine CFTR et la voie d’activation d’eIF5A". Thesis, Nice, 2015. http://www.theses.fr/2015NICE4030.
Pełny tekst źródłaOxidative stress represents a particular cellular condition, characterized by an intracellular increase in thereactive species level. These species are highly reactive towards biomolecules and result of oxygenconsumption by biological systems essentially through respiration. Deregulation of the cellular oxidativestate can initiate adaptive processes (as elevation adaptation) or several human pathologies (stroke,infarct). This thesis work has been devoted to the study of two news potential targets allowing atolerance/resistance towards disequilibrium of oxidative stress; the first one is CFTR, a channel protein(«Cystic Fibrosis Transmembrane conductance Regulator»), and the second one is the activation pathwayof the translation factor eIF5A («eukaryotic Initiation translation Factor 5A»). Based on the peculiaractivity of CFTR, consisting in the transport of glutathione, the major antioxidant of the cell, weevidenced the role of CFTR in the management of cellular oxidative state during cytotoxic drugexposure (cisplatin) or during adaptation to chronical hypoxia. The second target, eIF5A is the only oneprotein described as post-translationally modified by fixation of a hypusine residue. We demonstratedthat inhibition of eiF5A activation protect cells from reactive oxygen species generated during anoxia. Atcellular level, this protection is accompanied with deep metabolic and mitochondrial changes. Usinganimal models, we showed that inhibition of this eiF5A activation allows a tolerance against ischemicaccident in different organs (kidney and brain). These fundamentals results can have extensiveapplication in human clinical use (infarct, stroke, graft)
Champion, Antony. "Contrôle de la division cellulaire chez les plantes : identification d'une voie de signalisation de type SIN (Septum Initiation Network)". Paris 11, 2003. http://www.theses.fr/2003PA112035.
Pełny tekst źródłaThe time course of events shared by Eucaryotes all along the cell cycle, is strictly controlled by mitotic complexes involving the CDK/cyclin proteins. Studies carried out on S. Cerevisiae and S. Pombe enlight the involvement of an additional signalling cascade, the function of which consists in keeping the cytokinesis in concordance with the end of the mitosis. In S. Pombe, the signalling pathway is named SIN for Septum Initiation Network. Led by the analogy shared with yeast, we identified and analyzed the role of many items of the corresponding plant pathway. We identified A. Thaliana and B. Napus homologues of the fission yeast G protein spg1p (AtSGP1, AtSGP2), the kinase cdc7p (AtMAP3Ke1, AtMAP3Ke2, BnMAP3Ke1) and the kinase sid1p (AtMAP4Kα1, AtMAP4Kα2, BnMAP4Kα2). These are the first characterized homologues of a multicellular Eucaryote. Thcy might participate in a signalling module conserved along the evolution between fungi and plants. We demonstrated the existence of physical and functional interactions between both the plant and the s. Pombe SIN elements. AtSGP1/2, BnMAP3Ke1 and BnMAP4Kα2 are capable of complementing the spg1-B8, cdc7-24 and sid1-239 S. Pombe mutants respectively. Furthermore, we displayed anomalies in the cytokinesis process of wild type S. Pombe over-expressing the SIN-related proteins. An analysis of physical interplays between plant elements and those of the fission yeast clearly evidenced and confirmed the existence of a plant SlN-related signalling pathway. Partial complementation of the yeast mutants indicated that plant homologous proteins diverged from their yeast counterparts to some extend. In addition, we showed that the components colocalized within the nucleolus, which suggests a yet unnoticed regulating mechanisms of this pathway. These data, added to the expression patterns of the corresponding plant genes, and to the phenotypes of AtMAP3Ke1 antisense plants, led us to propose the consistent picture of a SIN related signalling pathway, which controls plant cell division
Addis, Vanessa. "Identification de protéines impliquées dans le tri aux endosomes multivésiculaires : Une voie utilisée dans le bourgeonnement du VIH-1". Université Louis Pasteur (Strasbourg) (1971-2008), 2008. http://www.theses.fr/2008STR13081.
Pełny tekst źródłaLate endosome or multivesicular body (MVB) is the major sorting station of the intracellular membrane trafficking pathway. MVB formation and sorting are two linked mechanisms which require Epsins, different protein complexes called ESCRTs (Endosomal Sorting Complex Required for Transport) and of membrane lipid phosphoinositides (PtdIns) PtdIns(3)P and PtdIns(3,5)P2. Epsins are proteins characterized by an ENTH domain (Epsin N-terminal homology) that is a membrane phosphoinositide-binding module. Our laboratory showed that two yeast Saccharomyces cerevisiae Epsins, Ent3 and Ent5, are specific PtdIns(3,5)P2 effectors at the endosome. They are required for proteins sorting at the MVB and interact with the Vps27/Hrs ESCRT-0 into different proteins complexes around 500 kDa. To determine additional proteins that are present in these complexes, Ent3 and Ent5 were used as baits in a poteome protoarray screen, determining their direct interactors. Among these many, we found an uncharacterized 70 kDa protein, we named Vps76. The vps76Δ cells display a specific MVB sorting defect of ubiquitinated- and PtdIns(3,5)P2-dependent cargos. We propose Vps76 is required for MVB sorting and is acting as a “sensor” of the multivesicular body sorting machinery in yeast
Baumgartner, Karin. "Public voices political discourse in the writings of Caroline de la Motte Fouqué". Oxford Bern Berlin Bruxelles Frankfurt, M. New York, NY Wien Lang, 2009. http://d-nb.info/991380282/04.
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