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1

Julien, Jennifer. Le clônage de la protéine virale CrmA dans un vecteur d'expression. Sudbury, Ont: Université Laurentienne, 2000.

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L, Hefferon Kathleen, red. Virus expression vectors. Tribandrum: Transworld Research Network, 2007.

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Mukhopadhyay, S. Plant virus, vector epidemiology and management. Enfield, NH: Science Publishers, 2010.

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Mukhopadhyay, S. Plant virus, vector epidemiology and management. Enfield, NH: Science Publishers, 2010.

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Mukhopadhyay, S. Plant virus, vector epidemiology and management. Enfield, NH: Science Publishers, 2010.

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T, Plumb R., red. Plant virus vector interactions. San Diego: Academic Press, 2002.

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Chan, C. K. Aphid-transmitted viruses and their vectors of the world. Vancouver: Research Branch, Agriculture Canada, 1991.

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8

International Symposium on Viruses with Fungal Vectors (1987 St. Andrews University). Viruses with fungal vectors. Wellesbourne, Warwick: Association of Applied Biologists, 1988.

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C, Asher M. J., Cooper J. I i Association of Applied Biologists, red. Viruses with fungal vectors: Proceedings of a conference at the University of St. Andrews, 25-27 August, 1987. Wellesbourne, Warwick: Association of Applied Biologists, 1988.

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Danielová, Vlasta. Relationships of mosquitoes to Ťahyňa virus as determinant factors of its circulation in nature. Prague: Academia, Publishing House of the Czechoslovak Academy of Sciences, 1992.

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Decraemer, W. The family Trichodoridae: Stubby root and virus vector nematodes. Dordrecht: Kluwer Academic Publishers, 1995.

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A, Machida Curtis, red. Viral vectors for gene therapy: Methods and protocols. Totowa, N.J: Humana Press, 2003.

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A, Machida Curtis, red. Viral vectors for gene therapy: Methods and protocols. Totowa, N.J: Humana Press, 2003.

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A, Machida Curtis, red. Viral vectors for gene therapy: Methods and protocols. Totowa, New Jersey: Humana Press, 2003.

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15

Yakov, Gluzman, Hughes Stephen H i Cold Spring Harbor Laboratory, red. Viral vectors. Cold Spring Harbor, N.Y: Cold Spring Harbor Laboratory, 1988.

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National Academy of Sciences Colloquium on Genetic Engineering of Viruses and of Virus Vectors (1996 Irvine, Calif.). National Academy of Sciences Colloquium: Genetic Engineering of Viruses and of Virus Vectors. Washington, D.C: National Academy of Sciences, 1996.

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E, Yunker Conrad, red. Arboviruses in arthropod cells in vitro. Boca Raton, Fla: CRC Press, 1987.

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18

Mukhopadhyay, S. Plant Virus, Vector. Taylor & Francis Group, 2017.

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Mukhopadhyay, S. Plant Virus, Vector. Taylor & Francis Group, 2010.

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Mukhopadhyay, S. Plant Virus, Vector. Taylor & Francis Group, 2010.

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Mukhopadhyay, S., i Mukhopadhyay Samrat. Plant Virus, Vector. Taylor & Francis Group, 2010.

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22

Muzyczka, Nicholas. Viral Expression Vectors (Current Topics in Microbiology and Immunology). Springer, 1992.

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Plumb, R. T. Plant Virus Vector Interactions. Elsevier Science & Technology Books, 2002.

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Adeno-Associated Virus (Aav) Vectors in Gene Therapy. Springer-Verlag Telos, 1996.

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Nagai, Yoshiyuki. Sendai Virus Vector: Advantages and Applications. Springer London, Limited, 2014.

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Nagai, Yoshiyuki. Sendai Virus Vector: Advantages and Applications. Springer, 2016.

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Biloshytsky, Vadym, i Roman Cregg. Pioneering use of gene therapy for pain. Redaktorzy Paul Farquhar-Smith, Pierre Beaulieu i Sian Jagger. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198834359.003.0083.

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The landmark paper discussed in this chapter is ‘Gene therapy for pain: Results of a Phase I clinical trial’, published by Fink et al. in 2011. In this study, the first of its kind, researchers studied the efficacy and safety of a modified herpes simplex virus (HSV) vector used to deliver PENK, which encodes proenkephalin, which is cleaved into the enkephalin peptides Met-enkephalin and Leu-enkephalin, which induce analgesia by acting on opioid receptors. The development of the HSV vector was based in part on results studies in which adenovirus, adeno-associated virus, or non-viral vectors were used to overexpress genes. Overexpression of a variety of large molecules leads to a reduction in pain-related behaviour in animals. Gene therapy in the treatment of chronic pain seems to offer a promising alternative to systemic or highly invasive therapies. However, additional research is needed to determine the safety, effectiveness, and cost-efficiency of this approach.
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Saluzzo, Jean-Francois. La Guerre contre les virus. Plon, 2002.

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Drake, John M., Michael Bonsall i Michael Strand, red. Population Biology of Vector-Borne Diseases. Oxford University Press, 2020. http://dx.doi.org/10.1093/oso/9780198853244.001.0001.

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Population Biology of Vector-Borne Diseases is the first comprehensive survey of this rapidly developing field. The chapter topics provide an up-to-date presentation of classical concepts, reviews of emerging trends, synthesis of existing knowledge, and a prospective agenda for future research. The contributions offer authoritative and international perspectives from leading thinkers in the field. The dynamics of vector-borne diseases are far more intrinsically ecological compared with their directly transmitted equivalents. The environmental dependence of ectotherm vectors means that vector-borne pathogens are acutely sensitive to changing environmental conditions. Although perennially important vector-borne diseases such as malaria and dengue have deeply informed our understanding of vector-borne diseases, recent emerging viruses such as West Nile virus, Chikungunya virus, and Zika virus have generated new scientific questions and practical problems. The study of vector-borne disease has been a particularly rich source of ecological questions, while ecological theory has provided the conceptual tools for thinking about their evolution, transmission, and spatial extent.
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Viral vectors for gene therapy: Methods and protocols. New York: Humana Press, 2011.

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31

Harris, Kerry F., Oney P. Smith i James E. Duffus. Virus-Insect-Plant Interactions. Elsevier Science & Technology Books, 2001.

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Decraemer, W. Family Trichodoridae: Stubby Root and Virus Vector Nematodes. Springer London, Limited, 2013.

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Al-Rubeai, Mohamed, i Otto-Wilhelm Merten. Viral Vectors for Gene Therapy: Methods and Protocols. Humana Press, 2016.

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Viral Vectors for Gene Therapy: Methods and Protocols. Humana, 2019.

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Machida, Curtis A. Viral Vectors for Gene Therapy: Methods and Protocols (Methods in Molecular Medicine). Humana Press, 2002.

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36

Plumb, R. T. Interactions between Plant Viruses and their Vectors (Advances in Botanical Research, Volume 36) (Advances in Botanical Research). Academic Press, 2002.

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Plumb, R. T. Interactions between Plant Viruses and their Vectors (Advances in Botanical Research, Volume 36) (Advances in Botanical Research). Academic Press, 2002.

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38

Gould, E. A. Mosquito-borne arboviruses. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780198570028.003.0039.

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The arboviruses are all single-stranded RNA viruses, although they belong to four different viral families. Several important human pathogens belong to the mosquito-borne arboviruses including yellow fever, Japanese encephalitis and Rift Valley Fever. They cause a wide range of illnesses from unrecognised infection to severe systemic disease with hemorrhagic complications and encephalitis with a high mortality similar range of illnesses is seen in infected animals.Arboviruses have several unique characteristics, these include; an ability to infect and be transmitted by mosquitos, ticks, midges, sand flies, bugs, fleas, blackflies and horseflies. They infect vertebrate hosts which may amplify virus for invertebrate vectors that feed on infected vertebrates. An ability to replicate in anthropods, with little pathology and in vertebrates often with significant pathology. Many arboviruses are Zoonotic.Control methods depend on the epidemiology of particular viruses, but epidemic vector control through control of insect breeding sites and the use of insecticide spraying have been successfully used in the past. Effective vaccines are available for yellow fever and Japanese encephalitis.
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(Editor), Onder Ergonul, i Chris A. Whitehouse (Editor), red. Crimean-Congo Hemorrhagic Fever: A Global Perspective. Springer, 2007.

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Ergonul, Onder, i Chris A. Whitehouse. Crimean-Congo Hemorrhagic Fever: A Global Perspective. Springer London, Limited, 2007.

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Ergonul, Onder, i Chris A. Whitehouse. Crimean-Congo Hemorrhagic Fever: A Global Perspective. Springer Netherlands, 2010.

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42

Finn, Matthew. West Nile Virus. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199976805.003.0053.

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West Nile virus (WNV) is a single-stranded RNA virus of the Flavivirus family that is transmitted via a mosquito vector, typically causing fever and capable of causing meningoencephalitis. Although mortality is low, it can lead to debilitating neuroinvasive disease in some patients. WNV is a leading cause of domestically-acquired arboviral disease and most commonly occurs in late August and early September. Consider WNV in otherwise unexplained cases of meningitis or encephalitis. Initial testing should consist of cerebrospinal fluid (CSF) analysis and West Nile immunoglobulin M enzyme-linked immunosorbent assay in serum and/or CSF. WNV is a nationally notifiable disease. Prevention remains the key to controlling this disease. Reducing the breeding grounds of the Culex mosquito and using insect repellant to prevent bites are two important strategies.
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Mueller, Dana. Malaria and Dengue Fever. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199976805.003.0052.

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Malaria is a vector-borne parasitic illness characterized by acute fever, headache, chills, and vomiting. Medications must target both the parasite’s active and inactive forms. During pregnancy, treatment regimens should consist of quinine and clindamycin. Person-to-person transmission can occur via sharing of blood products or during pregnancy. It is possible to contract malaria even while on prophylactic medications because resistance is widespread. Country-specific recommendations for prophylaxis can be found in the CDC’s annual Health Information for International Travel Protection against mosquito bites. Dengue Fever is a vector-borne viral infection that causes a flu-like illness with occasional lethal complications. It occurs primarily in tropical and subtropical regions. All treatment is supportive, ranging from oral rehydration to intravenous fluid administration and vasopressor support. Aspirin and NSAIDs are contraindicated in this population. Person-to-person transmission can occur via sharing of blood products or during pregnancy, although vertical transmission is rare.
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Facts about mosquito control and West Nile virus. [Springfield, Ill.?]: The Dept., 2003.

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45

Clement, Jan, i Piet Maes. Hantaviral infections. Redaktor Vivekanand Jha. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199592548.003.0188_update_001.

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Hantavirus disease is a viral zoonosis, caused by inhalation of infectious aerosolized excreta from chronically infected rodents, which are both the reservoir and the vector of different hantavirus species. Hantavirus infections manifest mainly as haemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome, which traditionally but incorrectly were thought to be caused by exclusively Old World hantaviruses and New World hantaviruses, respectively.Hantavirus diseases are characterized by non-specific flu-like symptoms, followed by a sometimes lethal capillary leak syndrome, haemorrhage, and rarely by shock. Infection is accompanied by augmented release of pro-inflammatory cytokines which indirectly causes organ damage. Diagnosis can be made by serology or plaque reduction neutralization tests, detection of viral proteins by Western blot assay, or detection of hantavirus genome by reverse transcription-polymerase chain reaction. Treatment is mainly supportive.Together with leptospirosis, haemorrhagic fever with renal syndrome is the only form of acute kidney injury against which vaccines are in use, but a World Health Organization-licensed vaccine is still lacking.
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Crawford, Dorothy H. Viruses: A Very Short Introduction. Oxford University Press, 2018. http://dx.doi.org/10.1093/actrade/9780198811718.001.0001.

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Viruses: A Very Short Introduction outlines the origins, structure, and method of infection of a vast variety of viruses and demonstrates how clever these entities appear to be. It explains the vital role viruses play in the ocean’s delicate ecosystem and discusses the impact of global warming, which is increasing the range of vector-transmitted viruses such as dengue, yellow fever, and West Nile virus. The recent Ebola and Zika epidemics, as well as Middle East Respiratory Syndrome, are also discussed. Can we ever live in harmony with viruses? This VSI considers the ways in which we may need to adapt to prevent emerging viruses with devastating consequences.
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Grant, Warren, i Martin Scott-Brown. Principles of oncogenesis. Redaktorzy Patrick Davey i David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0322.

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It is obvious that the process of developing cancer—oncogenesis—is a multistep process. We know that smoking, obesity, and a family history are strong independent predictors of developing malignancy; yet, in clinics, we often see that some heavy smokers live into their nineties and that some people with close relatives affected by cancer spend many years worrying about a disease that, in the end, they never contract. For many centuries scientists have struggled to understand the process that make cancer cells different from normal cells. There were those in ancient times who believed that tumours were attributable to acts of the gods. Hippocrates suggested that cancer resulted from an imbalance between the black humour that came from the spleen, and the other three humours: blood, phlegm, and bile. It is only in the last 100 years that biologists have been able to characterize some of the pathways that lead to the uncontrolled replication seen in cancer, and subsequently examine exactly how these pathways evolve. The rampant nature by which cancer invades local and distant tissues, as well its apparent ability to spread between related individuals led some, such as Peyton Rous in 1910, to suggest that cancer was an infectious condition. He was awarded a Nobel Prize in 1966 for the 50 years of work into investigating a link between sarcoma in chickens and a retrovirus that became known as Rous sarcoma virus. He had shown how retroviruses are able to integrate sequences of DNA coding for errors in cellular replication control (oncogenes) by introducing into the human cell viral RNA together with a reverse transcriptase. Viruses are now implicated in many cancers, and in countries where viruses such as HIV and EBV are endemic, the high incidence of malignancies such as Kaposi’s sarcoma and Burkitt’s lymphoma is likely to be directly related. There are several families of viruses associated with cancer, broadly classed into DNA viruses, which mutate human genes using their own DNA, and retroviruses, like Rous sarcoma virus, which insert viral RNA into the cell, where it is then transcribed into genes. This link with viruses has not only led to an understanding that cancer originates from genetic mutations, but has also become a key focus in the design of new anticancer therapies. Traditional chemotherapies either alter DNA structure (as with cisplatin) or inhibit production of its component parts (as with 5-fluorouracil.) These broad-spectrum agents have many and varied side effects, largely due to their non-specific activity on replicating DNA throughout the body, not just in tumour cells. New vaccine therapies utilizing gene-coding viruses aim to restore deficient biological pathways or inhibit mutated ones specific to tumour cells. The hope is that these gene therapies will be effective and easily tolerated by patients, but development is currently progressing with caution. In a trial in France of ten children suffering from X-linked severe combined immunodeficiency and who were injected with a vector that coded for the gene product they lacked, two of the children subsequently died from leukaemia. Further analysis confirmed that the DNA from the viral vector had become integrated into an existing, but normally inactive, proto-oncogene, LM02, triggering its conversion into an active oncogene, and the development of life-threatening malignancy. To understand how a tiny change in genetic structure could lead to such tragic consequences, we need to understand the molecular biology of the cell and, in particular, to pay attention to the pathways of growth regulation that are necessary in all mammalian cell populations. Errors in six key regulatory pathways are known as the ‘hallmarks of cancer’ and will be discussed in the rest of this chapter.
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Bialer, Philip, Kenneth Ashley i John Grimaldi. Substance-Related and Addictive Disorder? The Special Role in HIV Transmission. Redaktorzy Mary Ann Cohen, Jack M. Gorman, Jeffrey M. Jacobson, Paul Volberding i Scott Letendre. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199392742.003.0014.

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Substance use disorders have been linked to HIV/AIDS since the beginning of the epidemic. Injecting drug use can serve as a mode of viral transmission and in some parts of the world and among certain populations is the primary vector of transmission. Substances of misuse implicated in HIV transmission include alcohol, cocaine, heroin, methamphetamine, and Ecstasy. Use of both non-injecting drugs and alcohol is also associated with increased sexual and other risk-taking behaviors and seroconversion. In addition, substance use disorders and other psychiatric disorders often coexist and can have profound effects on the medical management of HIV/AIDS as well as on a person’s social interaction and quality of life. Many people with HIV/AIDS therefore suffer from triple diagnoses necessitating comprehensive evaluation and treatment and a team approach involving medical, mental health, and substance use caregjvers. Treatment can include detoxification, harm reduction, individual, group, and family therapy, medication, and awareness of potential drug interactions.
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Clement, Jan. Acute kidney injury and hantavirus disease. Redaktor Norbert Lameire. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199592548.003.0242_update_001.

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Hantavirus disease or at least its renal form, the so-called haemorrhagic fever with renal syndrome is the only globally emerging acute kidney injury (AKI) form, and currently without doubt the most underestimated form of community-acquired AKI. Hantavirus disease is a viral zoonosis, caused by inhalation of infectious aerosolized excreta from chronically infected rodents, which are both the reservoir and the vector of different hantavirus species. Clinical presentation consists of sudden flu-like symptoms (fever, headache, myalgia), followed by gastrointestinal discomfort and AKI, often with anuria or oliguria. More rarely, acute myopia and/or non-cardiogenic acute lung oedema or injury is the presenting or complicating symptom. Laboratory hallmarks are initial thrombocytopenia and proteinuria, raised C-reactive protein and lactate dehydrogenase, left-shift leucocytosis, and typical but transient serum lipid disturbances. Spontaneous remission occurs within 2–3 weeks without sequelae. Case fatality rate is between 0.1% and 15% according to the infecting hantavirus species, but most infections show in fact an asymptomatic or paucisymptomatic presentation. Treatment is only supportive, but may necessitate life-saving intensive care techniques. Together with leptospirosis, haemorrhagic fever with renal syndrome is the only form of AKI against which different vaccines are in use, but a World Health Organization-licensed hantavirus vaccine is still lacking.
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Manual para aplicar rociado residual intradomiciliario en zonas urbanas para el control de Aedes aegypti. Organización Panamericana de la Salud, 2019. http://dx.doi.org/10.37774/9789275321140.

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La gravedad de la situación epidemiológica reciente en Latinoamérica, con la cocirculación de los virus del dengue, del chikungunya y de la fiebre de Zika, la aparición de casos de microcefalia y otros padecimientos asociados (p. ej., el síndrome de Guillain-Barré) y la emergencia de epizootias de fiebre amarilla, motivaron la declaración de emergencia en las Américas por la Organización Mundial de la Salud en 2016.1 Ante la ausencia de un tratamiento específico y de vacunas contra el dengue, el chikungunya y el Zika, y considerando las limitaciones de las estrategias actuals de control vectorial, se urgió a incrementar y complementar las lternativas disponibles para mejorar el control del mosquito vector Aedes aegypti. Además, existe la dificultad de mantener coberturas de vacunación homogéneas y adecuadas contra la fiebre amarilla en centros urbanos endémicos, lo cual conlleva el riesgo de la circulación urbana de dicha enfermedad … Manual para aplicar rociado residual intradomiciliario en zonas urbanas para el control de Aedes aegypti no solo está dirigido al personal operativo y los mandos medios y directivos de los programas de prevención y control de las enfermedades transmitidas por Aedes, sino también a la comunidad académica relacionada con la investigación operativa sobre RRI-Aedes, a los controladores de plagas privados y al público en general.
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