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Gotowa bibliografia na temat „Vafs”

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Data publikacji: 25 lipca 2024

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Artykuły w czasopismach na temat "Vafs"

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Wang, Weirong, Ting Jing, Xiaofeng Yang, Yanhao He, Bo Wang, Yunfang Xiao, Chenxu Shang, Jiye Zhang i Rong Lin. "Hydroxytyrosol regulates the autophagy of vascular adventitial fibroblasts through the SIRT1-mediated signaling pathway". Canadian Journal of Physiology and Pharmacology 96, nr 1 (styczeń 2018): 88–96. http://dx.doi.org/10.1139/cjpp-2016-0676.

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Hydroxytyrosol (HT), a phenolic compound in olive oil, exerts an anti-inflammatory effect in cardiovascular diseases. Recent studies found that autophagy was a therapeutic target of diseases. However, the effect of HT on autophagy in vascular adventitial fibroblasts (VAFs) remains unknown. Thus, in this study, we aimed to determine the effect of HT on cell autophagy and related signaling pathway and whether HT regulates the inflammatory response through autophagy in VAFs. Our results showed that HT promoted cell autophagy by increasing the conversion of LC3 and Beclin1 expression and the autophagic flux in VAFs stimulated with tumor necrosis factor-α (TNF-α). HT also upregulated the expression of the deacetylase sirtuin 1 (SIRT1) protein and mRNA compared with the TNF-α group. The molecular docking studies showed the good compatibility between HT and SIRT1, indicating that HT might act through SIRT1. Further study found that HT regulated autophagy through SIRT1-mediated Akt/mTOR suppression in VAFs. In addition, HT inhibited TNF-α-induced inflammatory response in VAFs through SIRT1. Furthermore, the study showed that HT inhibited the inflammatory response of VAFs through autophagy. These findings indicate that HT regulates the autophagy of VAFs through SIRT1-mediated Akt/mTOR suppression and then inhibits the inflammatory response of VAFs.
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Pasi, Bhaveshkumar N., Subhash K. Mahajan i Santosh B. Rane. "A Method for Performing Forging Operation: A Perspective of Industry 4.0". Recent Patents on Mechanical Engineering 14, nr 3 (9.08.2021): 423–35. http://dx.doi.org/10.2174/2212797614666210120110548.

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Background: Cold forging operation is done on small as well as large scale in manufacturing industries. These industries are facing problems such as higher rejection rate of the final product, low productivity, the high number of accidents during production, etc. Objective: The purpose of this research work is to develop a Voice-Assisted Forging System (VAFS) with a lower rejection rate, higher productivity, and lower number of accidents during production. Methods: Based on recently published journals and patents, traditional and automatic forging operations, Industry 4.0, and voice assisted systems are reviewed and VAFS is designed and developed. Then, the trial is taken on VAFS to investigate its performance. Finally, limitations and future research of the VAFS are proposed. Results: It is found that after implementation of the VAFS the average rejection count is reduced by 90.3 percentage, the operational productivity is increased by 71.2 percentage, and process accuracy is increased from 92.75 percentage to 99.30 percentage. Also, the number of accidents is reduced to zero. In comparison with the manual forging operation, the VAFS occupies less space, and it is easy to operate. Conclusion: This system will help the workers as well as the owner of industries to create a better man and machine relationship and to have a human-friendly working environment. VAFS reduces exhaustion and hassle of employees, components rejection, and energy consumptions in the production line.
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Wang, Wei-Rong, Ting-Ting Li, Ting Jing, Yan-Xiang Li, Xiao-Feng Yang, Yan-Hao He, Wei Zhang, Rong Lin i Ji-Ye Zhang. "SIRT1 Regulates the Inflammatory Response of Vascular Adventitial Fibroblasts through Autophagy and Related Signaling Pathway". Cellular Physiology and Biochemistry 41, nr 2 (2017): 569–82. http://dx.doi.org/10.1159/000457878.

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Background/Aims: Autophagy is a lysosomal degradation pathway that is essential for cellular survival, differentiation, and homeostasis. Sirtuin 1 (SIRT1), a NAD+-dependent deacetylase, plays a pivotal role in modulation of autophagy. Recent studies found that autophagy was involved in the regulation of inflammatory response. In this study, we aimed to determine the effect of SIRT1 on autophagy and inflammation, and whether autophagy can regulate the inflammatory response in vascular adventitial fibroblasts (VAFs). Methods: Cell autophagy was evaluated by fluorescence microscope and transmission electron microscopy. The expression of protein and mRNA were determined by Western blot analysis and real time-PCR. The production of cytokine was detected by ELISA. Results: TNF-α induced autophagy and increased SIRT1 expression in VAFs. SIRT1 activator resveratrol enhanced TNF-α-induced VAF autophagy. In contrast, SIRT1 knockdown attenuated VAF autophagy. Both the Akt inhibitor MK2206 and mTOR inhibitor rapamycin further increased TNF-α-induced VAF autophagy. Furthermore, SIRT1 knockdown increased Akt phosphorylation and inhibited the autophagy in VAFs. However, MK2206 attenuated the effect of SIRT1 knockdown on VAF autophagy. In addition, ingenuity pathway analysis showed that there is a relationship between cell autophagy and inflammation. We found that SIRT1 knockdown increased the expression of NLRP3 and interleukin (IL)-6 and promoted the production of IL-1β in VAFs. Further study showed that autophagy activation decreased the expression of NLRP3 and IL-6 and inhibited the production of IL-1β, whereas autophagy inhibition increased the inflammatory response of VAFs. More importantly, our study showed that autophagy was involved in the degradation of NLRP3 through the autophagy-lysosome pathway. Conclusion: SIRT1 not only regulates VAF autophagy through the Akt/mTOR signaling pathway but also suppresses the inflammatory response of VAFs through autophagy.
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Tseng, Benjamin Y., Byron J. Gajewski i Patricia M. Kluding. "Reliability, Responsiveness, and Validity of the Visual Analog Fatigue Scale to Measure Exertion Fatigue in People with Chronic Stroke: A Preliminary Study". Stroke Research and Treatment 2010 (2010): 1–7. http://dx.doi.org/10.4061/2010/412964.

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Background and Purpose. Post-Stroke Fatigue (PSF) is a prevalent yet commonly neglected issue that impacts daily functions and quality of life in people post-stroke. To date no studies have attempted to validate a clinically-feasible and reliable instrument to quantify PSF. We developed the Visual Analog Fatigue Scale (VAFS) to eliminate difficulties and poor data validity in testing people post-stroke. The purpose of this study was to evaluate the reliability, responsiveness, and validity of the VAFS.Methods. Twenty-one people post-stroke (12 males, age =59.5±10.3years; time post-stroke =4.1±3.5years) participated. Subjects underwent a standardized fatigue-inducing exercise; fatigue level was assessed at rest, immediately after exercise, and after recovery. The same protocol was repeated after 14 days.Results. ICC values for the VAFS at rest was 0.851 (CI = 95%,0.673 ∼ 0.936,P<.001), immediately after exercise was 0.846 (CI = 95%,0.663 ∼ 0.934,P<.001), and 15 minutes after exercise was 0.888 (CI = 95%,0.749 ∼ 0.953,P<.001). The ES values for at-rest to post-exercise and for post-exercise to post-recovery were 14.512 and 0.685, respectively. Using paired t-test, significant difference was found between VAFS scores at-rest and post-exercise (P<.001), and between post-exercise and post-recovery (P<.001).Conclusion. Our data suggests good reliability, responsiveness, and validity of the VAFS to assess exertion fatigue in people post-stroke.
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Niwinska, Anna, Aneta Bałabas, Maria Kulecka, Anna Kluska, Magdalena Piątkowska, Agnieszka Paziewska, Kazimiera Pyśniak, Wojciech Olszewski, Michał Mikula i Jerzy Ostrowski. "Limited Practical Utility of Liquid Biopsy in the Treated Patients with Advanced Breast Cancer". Diagnostics 10, nr 8 (28.07.2020): 523. http://dx.doi.org/10.3390/diagnostics10080523.

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Recently, liquid biopsy has emerged as a tool to monitor oncologic disease progression and the effects of treatment. In this study we aimed to determine the clinical utility of liquid biopsy relative to conventional oncological post-treatment surveillance. Plasma cell-free (cf) DNA was collected from six healthy women and 37 patients with breast cancer (18 and 19 with stage III and IV tumors, respectively). CfDNA was assessed using the Oncomine Pan-Cancer Cell-Free Assay. In cfDNA samples from patients with BC, 1112 variants were identified, with only a few recurrent or hotspot mutations within specific regions of cancer genes. Of 65 potentially pathogenic variants detected in tumors, only 19 were also discovered in at least one blood sample. The allele frequencies of detected variants (VAFs) were <1% in cfDNA from all controls and patients with stage III BC, and 24/85 (28.2%) variants had VAFs > 1% in only 8 of 25 (32%) patients with stage IV BC. Copy number variations (CNVs) spanning CDK4, MET, FGFR1, FGFR2, ERBB2, MYC, and CCND3 were found in 1 of 12 (8%) and 8 of 25 (32%) patients with stage III and IV tumors, respectively. In healthy controls and patients without BC progression after treatment, VAFs were <1%, while in patients with metastatic disease and/or more advanced genomic alterations, VAFs > 1% and/or CNV were detected in approximately 30%. Therefore, most patients with stage IV BC could not be distinguished from those with stage III disease following therapy, based on liquid biopsy results.
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DeZern, Amy E., Johannes Goll, Travis L. Jensen, Sridhar N. Srivatsan, Nancy K. Gillis, Gregory A. Abel, Eric Padron i in. "Correlation between Peripheral Blood and Bone Marrow Somatic Mutations Among Patients with Suspected or Established Myelodysplastic Syndromes from the National MDS Study". Blood 142, Supplement 1 (28.11.2023): 1860. http://dx.doi.org/10.1182/blood-2023-178587.

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INTRODUCTION: Myelodysplastic Syndromes (MDS) are caused by progressive clonal dominance of mutated hematopoietic stem cells. While assessment of mutations in peripheral blood (PB) is an established standard for monitoring patients with some diseases such as chronic myeloid leukemia, the sensitivity and precision of PB screening and monitoring for somatic mutations in patients with MDS and related conditions such as clonal cytopenias of undetermined significance (CCUS) is less certain. Multiple published guidelines require bone marrow (BM) evaluations for the above, an invasive procedure not often performed outside of clinical trials. We compared somatic mutations and variant allele frequencies (VAFs) in paired PB and BM samples to assess the utility of PB results as a surrogate for diagnosis and monitoring. METHODS: The National MDS Natural History Study (National MDS Study) is an observational longitudinal cohort study of cytopenic patients suspected of having a diagnosis of MDS. All patients have PB and BM sampled when entering the study, prior to formal diagnosis. For this study, paired PB and BM baseline DNA samples from 36 patients were assessed for somatic mutations. Only subjects with minimum of one variant detected in their BM were included in this study. DNA was extracted from PB using an automated FlexSTAR (AutoGen) and from BM cell pellets using a QIAamp DNA Mini Kit (QIAGEN). Targeted exon sequencing of 96 genes was performed using a NovaSeq 6000 at a mean coverage of &gt;1,200X and a mean breadth (bases covered at ≥100X) of &gt;99.9%. Reads were aligned against a patched version of the build GRCh38 using BWA-MEM. VarScan2 was used to detect single nucleotide variants and short insertions/deletions with a minimum VAF of 2% and 5%, respectively. Resulting variants from 53 genes were manually reviewed to retain likely disease-causing variants. Correlation analysis between PB and BM VAFs was performed using Pearson correlation and linear regression. To confirm paired samples were sourced from the same subject, the Somalier software using a set of highly polymorphic SNPs across different ancestries was utilized to ensure a high level of relatedness. RESULTS: The 36 patients included 10 (28%) with MDS, 2 (6%) with MDS/MPN, 1 (3%) with AML (&lt;30% blasts), and 23 (64%) with CCUS. The median age was 73 years (Table 1). Five of 36 patients had circulating PB blasts. Among the 191 mutations identified, the most common were TET2 (27%), SRSF2 (13%), DNMT3A (9%), SF3B1 (8%), and ASXL1 (8%). Correlation analysis of mutations (n=180) shared between paired PB and BM samples indicated a linear relationship between VAFs detected in PB and BM (Pearson correlation r=0.95, Figure 1), with a slight increase in variance observed with increasing VAFs. The deviation from the perfect (grey line) to the observed (yellow line) linear fit indicated that PB VAFs underestimated VAFs in BM by approximately 23% overall (Figure 1). For example, a BM VAF of 0.20 translated to a mean PB VAF of 0.16 based on the regression fit. The lower sensitivity was confirmed when looking at the number of total missed variants (present in BM, absent in PB): 9 of 101 (9%). Two mutations were detected in PB, but not BM. These mutations and diagnoses were 1) ETNK1 (VAF 0.026) in a patient with MDS-EB-1; and 2) CBL (VAF 0.021) in a patient with MDS with isolated del5q. Next, we assessed the relationship between percent of detected mutations and minimum VAF that was detected using linear regression and found that the higher the minimum VAF, the lower the percent of missed mutations. For example, for a 0.1, 0.2, and 0.3 minimum VAF, 11%, 9%, and 8% of BM mutations were missed, respectively. There was no difference in concordance between MDS and CCUS. SUMMARY & CONCLUSIONS: PB can be used to reliably identify somatic mutations in patients with suspected or established MDS and related conditions. Linear correlation between PB and BM VAFs showed, unsurprisingly, that BM mutations with higher VAFs are more likely to be detected. If PB is positive, this method of variant detection may be used potentially to diagnose and monitor. However, if negative (or if VAF is less than 0.10), bone marrow genomics are still necessary to exclude detectable clonal mutations. For quantitative predictive tools that use VAFs, PB VAFs would need to be corrected to improve predictive results; our estimated linear regression equation could be used to guide this in a larger prospective study.
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Liu, Lin, Qingzhuo Cui, Junna Song, Yang Yang, Yixin Zhang, Jiapeng Qi i Jingshan Zhao. "Hydroxysafflower Yellow A Inhibits Vascular Adventitial Fibroblast Migration via NLRP3 Inflammasome Inhibition through Autophagy Activation". International Journal of Molecular Sciences 24, nr 1 (22.12.2022): 172. http://dx.doi.org/10.3390/ijms24010172.

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Inflammation is closely associated with progression of vascular remodeling. The NLRP3 inflammasome is the key molecule that promotes vascular remodeling via activation of vascular adventitia fibroblast (VAF) proliferation and differentiation. VAFs have a vital effect on vascular remodeling that could be improved using hydroxysafflower yellow A (HSYA). However, whether HSYA ameliorates vascular remodeling through inhibition of NLRP3 inflammasome activation has not been explored in detail. Here, we cultured primary VAFs and analyzed the migration of VAFs induced by angiotensin II (ANG II) to determine the potential effects and mechanism of HSYA on VAF migration. The results thereof showed that HSYA remarkably inhibited ANG II-induced VAF migration, NLRP3 inflammasome activation, and the TLR4/NF-κB signaling pathway in a dose-dependent manner. In addition, it is worth noting that LPS promoted ANG II-induced VAF migration and NLRP3 inflammasome assembly, which could be significantly reversed using HSYA. Moreover, HSYA could be used to inhibit NLRP3 inflammasome activation by promoting autophagy. In conclusion, HSYA could inhibit ANG II-induced VAF migration through autophagy activation and inhibition of NLRP3 inflammasome activation through the TLR4/NF-κB signaling pathway.
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Fu, Guodong, Ronald S. Chazen, Eric Monteiro, Allan Vescan, Jeremy L. Freeman, Ian J. Witterick i Christina MacMillan. "Facilitation of Definitive Cancer Diagnosis With Quantitative Molecular Assays of BRAF V600E and TERT Promoter Variants in Patients With Thyroid Nodules". JAMA Network Open 6, nr 7 (28.07.2023): e2323500. http://dx.doi.org/10.1001/jamanetworkopen.2023.23500.

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ImportanceMolecular testing of the presence of pathogenic genomic variants in a tumor without quantifying the variant allele fraction (VAF) does not differentiate the variation extent among tumors, often resulting in an inconclusive diagnosis because of interpatient variability.ObjectiveTo examine the association between the quantification of VAFs of BRAF V600E and TERT promoter variants and a definitive cancer diagnosis of thyroid tumors.Design, Setting, and ParticipantsThis diagnostic study analyzed a cohort of 378 surgically resected thyroid tumors with a maximum dimension of 1 cm or larger between March 15, 2016, and March 16, 2020, and a separate cohort of 217 residual thyroid fine-needle aspiration (FNA) biopsy specimens obtained from January 22, 2020, to March 2, 2021, at Mount Sinai Hospital, Toronto, Ontario, Canada. Data analysis was conducted between February 1, 2021, and February 1, 2023.ExposuresQuantitative VAF assays of BRAF V600E and TERT promoter variants (C228T and C250T) were performed by digital polymerase chain reaction molecular assays.Main Outcomes and MeasuresThe VAFs of BRAF V600E and TERT promoter variants were correlated with tumor histologic diagnoses and histopathologic features to delineate the association of VAF assays with tumor malignancy. The receiver operating characteristic curve analysis, sensitivity, specificity, positive predictive value, negative predictive value, and logistic regression analysis based on follow-up histopathologic types were used to determine the diagnostic utility of the quantitative molecular assays.ResultsA total of 595 specimens, including 378 surgically resected thyroid tumors and 217 thyroid nodule FNA biopsy specimens, were collected from 580 patients (436 [75.2%] female with a mean [SD] age of 50 [16] years and 144 [24.8%] male with a mean [SD] age of 55 [14] years). Sensitive VAF assays of 378 thyroid tumors revealed the presence of the BRAF V600E variant in 162 tumors (42.9%), with 26 (16.0%) at a low VAF of 1% or less and 136 (84.0%) at a high VAF of greater than 1%, and the presence of TERT promoter variants in 49 tumors (13.0%), including 45 C228T variants (91.8%), 15 (33.3%) of which were quantified as having a low VAF (≤1%) and 30 (66.7%) as having a high VAF (&amp;gt;1%), and 4 C250T variants (8.2%) with VAFs between 40.0% and 47.0%. All tumors detected with BRAF V600E and/or TERT promoter variants, whether at low or high VAFs, received a definitive cancer diagnosis. Further analysis delineated a significant association between high VAFs of either variant individually or different VAF levels for both variants in coexistence and aggressive histopathologic features of tumors. Excluding low VAFs assisted in identifying patients at an intermediate-to-high risk of recurrence (odds ratio, 5.3; 95% CI, 1.9-14.6; P = .001). The VAF assays on the residual FNA biopsy specimens showed a high agreement to those on surgical tissues (κ = 0.793, P &amp;lt; .001) and stratified malignancy in 40 of 183 indeterminate FNA cases (21.9%), with a sensitivity of 93.8% (95% CI, 67.7%-99.7%), specificity of 90.0% (95% CI, 75.4%-96.7%), positive predictive value of 78.9% (95% CI, 53.9%-93.0%), and negative predictive value of 97.3% (95% CI, 84.2%-99.9%).Conclusions and RelevanceThis diagnostic study suggests that sensitive quantitative VAF assays of BRAF V600E and TERT promoter variants can elucidate the interpatient variability in tumors and facilitate a definitive cancer diagnosis of thyroid nodules by differentiating the variation extent of genomic variants, even at low VAFs.
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Cher, Chae Yin, Zi Yi Lim, Daryl Tan, Hae Tha Mya, Wichean Mongkonsritragoon, Min-Han Tan i Yukti Choudhury. "An ultrasensitive amplicon-based sequencing panel for noninvasive molecular testing of hematological malignancies using blood." Journal of Clinical Oncology 38, nr 15_suppl (20.05.2020): e19511-e19511. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e19511.

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e19511 Background: Hematological malignancies, especially acute myeloid leukemia, myeloproliferative neoplasms, and myelodysplastic syndromes (MDS), present with distinct genomic alterations relevant to prognosis. Bone marrow (BM) is the primary sample source for genetic testing, but is obtained by an invasive biopsy procedure which carries risk of infection. An alternative non-invasive sample type to profile disease-relevant genomic alterations at diagnosis and subsequently, is desired for clinical decision making. An ultrasensitive sequencing panel was applied to peripheral blood (PB) as an alternative to BM, to demonstrate its utility for disease profiling and monitoring. Methods: A total of 27 pairs of matched PB and BM samples were obtained from patients with hematological malignancies including leukemia (n = 21), lymphoma (n = 4), multiple myeloma (n = 1) and MDS (n = 1). The sequencing panel covers 45 genes commonly mutated in myeloid and lymphoid malignancies. The panel is based on amplicon-sequencing and includes error correction for variant detection with allele frequency (VAF) as low as 0.1%. Optimized bioinformatics pipeline and in-house sequencing noise removal was used for variant selection and clonal analysis. Results: Complete concordance was seen for mutations detected in 23 of 27 patient-matched BM and PB paired samples. The likely cause of discordance in the other 4 pairs is attributable to mutations with low VAF ( < 0.5%). Overall, 91% of detected variants were concordant between PB and BM with strong correlation of VAFs (R = 0.9617). Serial testing trends correlated with stable disease with limited changes in VAFs (n = 2), and successful treatment response with rapidly falling VAFs (n = 5). In particular, 2 patients with FLT3-ITD and BCR-ABL1, respectively, identified at diagnosis had dramatic decrease in VAFs with respective targeted treatment. Conclusions: We report the utility of an ultrasensitive sequencing assay in PB with excellent concordance of mutations with BM, suggesting PB is a reliable alternative source for testing. In serial samples, the assay demonstrated value in treatment selection and response evaluation.
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Nasko, Dan, Phillip Pham, Stuti Joshi, Kristi Kim, Nairi Pezeshkian, Young Kim, Alexandra Sockell i Jonas Korlach. "Abstract 2432: Improved liquid biopsy assay performance using sequencing by binding (SBB)". Cancer Research 84, nr 6_Supplement (22.03.2024): 2432. http://dx.doi.org/10.1158/1538-7445.am2024-2432.

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Abstract Liquid biopsy is revolutionizing the field of early cancer detection research through non-invasive detection of tumor DNA in the blood. However, existing liquid biopsy assays are limited in their sensitivity for ctDNA detection at low variant allele frequencies (VAFs), with most relying on extreme sequencing depth and computational error correction to separate the true ctDNA signal from background errors. This limitation is particularly problematic in the area of early cancer detection, in which expected ctDNA allele frequencies are extremely low. Novel strategies are therefore needed to help improve liquid biopsy assay sensitivity and reduce per-sample sequencing requirements. Here we describe PacBio’s application of the Onso short-read sequencing system to enable detection of ctDNA at low VAFs using the SeraCare Complete ctDNA Mutation Mix reference standard. The Onso system makes use of a novel sequencing by binding (SBB) method to achieve up to 15x greater quality scores, with ≥90% of reads at Q40 or above. We performed targeted capture and sequencing of libraries prepared from the SeraCare reference mix diluted into WT human DNA at the following VAFs: 0.00% (WT), 0.05%, 0.10%, 0.25%, and 0.50%, and compared the sensitivity at each VAF for SBB compared to a competitor method using sequencing by synthesis (SBS) at varying sequencing depths. We observed superior sensitivity for ctDNA detection at low VAFs (0.05%, 0.1%) using SBB at half the sequencing depth compared to SBS, in part due to reduced false positive calling in the WT sample for SBB. Furthermore, SBB was able to achieve comparable sensitivity results to SBS using four-fold less sequencing, and without the use of computational error correction. Finally, combining SBB with computational error-correction methods boosted sensitivity even further, suggesting an additive value for these technologies. Taken together, our results demonstrate the potential of SBB to improve upon existing methods of liquid biopsy and better enable research on early cancer detection. Citation Format: Dan Nasko, Phillip Pham, Stuti Joshi, Kristi Kim, Nairi Pezeshkian, Young Kim, Alexandra Sockell, Jonas Korlach. Improved liquid biopsy assay performance using sequencing by binding (SBB) [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 2432.
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Rozprawy doktorskie na temat "Vafs"

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Castañeda, Castillejo Abel. "¿Habla, Vas?" Anthropía, 2014. http://repositorio.pucp.edu.pe/index/handle/123456789/78073.

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MELLO, SIMON. "VATS : Voice-Activated Targeting System". Thesis, KTH, Skolan för industriell teknik och management (ITM), 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-279837.

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Machine learning implementations in computer vision and speech recognition are wide and growing; both low- and high-level applications being required. This paper takes a look at the former and if basic implementations are good enough for real-world applications. To demonstrate this, a simple artificial neural network coded in Python and already existing libraries for Python are used to control a laser pointer via a servomotor and an Arduino, to create a voice-activated targeting system. The neural network trained on MNIST data consistently achieves an accuracy of 0.95 ± 0.01 when classifying MNIST test data, but also classifies captured images correctly if noise-levels are low. This also applies to the speech recognition, rarely giving wrong readings. The final prototype achieves success in all domains except turning the correctly classified images into targets that the Arduino can read and aim at, failing to merge the computer vision and speech recognition.
Maskininlärning är viktigt inom röstigenkänning och datorseende, för både små såväl som stora applikationer. Syftet med det här projektet är att titta på om enkla implementationer av maskininlärning duger för den verkligen världen. Ett enkelt artificiellt neuronnät kodat i Python, samt existerande programbibliotek för Python, används för att kontrollera en laserpekare via en servomotor och en Arduino, för att skapa ett röstaktiverat identifieringssystem. Neuronnätet tränat på MNIST data når en precision på 0.95 ± 0.01 när den försöker klassificera MNIST test data, men lyckas även klassificera inspelade bilder korrekt om störningen är låg. Detta gäller även för röstigenkänningen, då den sällan ger fel avläsningar. Den slutliga prototypen lyckas i alla domäner förutom att förvandla bilder som klassificerats korrekt till mål som Arduinon kan läsa av och sikta på, vilket betyder att prototypen inte lyckas sammanfoga röstigenkänningen och datorseendet.
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Zia, Seiar Ahmad. "The effect of different road load implementation strategies on fuel economy of USPS step vans". Morgantown, W. Va. : [West Virginia University Libraries], 2009. http://hdl.handle.net/10450/10375.

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Thesis (M.S.)--West Virginia University, 2009.
Title from document title page. Document formatted into pages; contains xii, 92 p. : ill. (some col.), col. map. Includes abstract. Includes bibliographical references (p. 79-81).
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Payne, Adam, i Benjamin Memic. "Radix : En administrativ webbapplikation för VACS". Thesis, Karlstads universitet, Institutionen för matematik och datavetenskap, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-39116.

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Företaget Evry Forest & Logistics Solutions AB i Karlstad har utvecklat systemet VACS (Virkes Administrativ Client/Server) som administrerar virkesaffärer för skogsindustrin. Eftersom kundbasen ständigt växer behöver Evry ett system där alla kunders produktkonfigurationer finns samlade på ett system och kan nås via ett web-baserat interface. Denna uppsats beskriver projektet Radix. Projektets huvudsakliga syfte var att skapa en administrativ plattform som hanterar de kunder som använder VACS. Projektet har resulterat i en användarbaserad webbapplikation med ett tillhörande program som ska fungera som ett hjälpmedel för att hitta en kunds produktkonfiguration i VACS källkod.
The company Evry Forest & Logistics Solutions AB in Karlstad has developed the VACS system (Lumber Administrative Client/Server) that manages the timber business for the forest industry. As the customer base is constantly growing Evry needs a system where all customer’s product configurations are gathered in one system and can be accessed via a web-based interface. This dissertation describes the Radix project. The project's main aim was to create an administrative platform that manages customers who use VACS. The project has resulted in a user-based web application with an associated program that will serve as a tool to find a client's product configuration in VACS source code.
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Nordin, Adam. "Översyn av bältessträckning i ViscoNip-vals". Thesis, Karlstads universitet, Institutionen för ingenjörsvetenskap och fysik (from 2013), 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-67710.

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The report was a finalization part of the thesis bachelor work in mechanical engineering at Karlstad University. A review of the ViscoNip roll belt stretch was made to Valmet. The background to the project was that the belts became resistant to wear, which meant that it was no longer necessary to adjust the machine direction. Previously the belt was moved in the machine direction to expose a new and fresh surface to even the wear. The increased quality of the belt has led to the possibility of applying a fixed side. The goal with the thesis work was to minimize the cost of the belt tension.  The project has gone thru a development process where project planning, product specification, concept generation, concept evaluation and layout design was included. Through a cost analysis and input from the relevant fitters and service staff, it was found that a trapezoidal screw was a highly rated solution for the head adjustment. Due to the requirement for continuous belt tension, the trapezoidal screw and a fixed end could not be combined.  As there were several advantages with the trapezoidal screw, a solution was created that was to combine a trapezoidal screw with a spring. These along with a fixed head became the winning concept. Before the thesis work, the cost of the ViscoNip roll belt stretch was 226 321 kr. In that price was installation, hydraulics, trapezoidal screw and displacement components.  Upon completion of the thesis, a fixed side was applied to the driving side together with a trapezoidal screw combined with a driver's spring. The estimated cost was instead 155 477 kr, a saving of 70 845 kr.
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Boková, Jana. "Ekonomická analýza podniku VAFO Praha, s.r.o". Master's thesis, Vysoká škola ekonomická v Praze, 2013. http://www.nusl.cz/ntk/nusl-193011.

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The aim of this Master's thesis is to carry out an economic analysis of the company VAFO PRAHA, s.r.o. in the period of 2007 - 2013. The thesis is divided into four sections - introduction, theoretical-methodological part, practical part, and conclusion. The introduction defines the goal and explained the reason for the choice of the topic. The theoretical and methodological part determines the methodology, which is applied in the practical part. During the analysis, I will use indicators like indicators of activity, and profitability. Financial health is assessed using creditworthy and bankruptcy models. The analyzed company is also compared with the industry results. In conclusion, I will summarize the results achieved and suggest recommendations.
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Faber, Svea Olivia [Verfasser]. "Uniportal VATS in der akuten Thoraxchirurgie : Outcome der uniportalen VATS bei Notfällen, Pleuraempyem und Pneumothorax / Svea Olivia Faber". Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2020. http://d-nb.info/1218077697/34.

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Pujolar, Joan. "De què vas, tio? /". Barcelona : Ed. Empúries, 1997. http://www.gbv.de/dms/sub-hamburg/251525244.pdf.

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Sulca, Muñoz Arturo. "Vals, sujeto y nación en el Perú". Bachelor's thesis, Pontificia Universidad Católica del Perú, 2005. http://tesis.pucp.edu.pe/repositorio/handle/123456789/615.

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Carringer, Malcolm. "Autologous vastransplantation the consequences for fertility, patency and intrinsic neural function : an experimental study in the rat /". Lund : Örebro : Dept. of Clinical Pharmacology, Lund University, Hospital ; Dept. of Urology, Örebro Medical Centre, 1997. http://books.google.com/books?id=daJsAAAAMAAJ.

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Książki na temat "Vafs"

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Heubeck, Martin. Intelligente Dienste im Telekommunikationsnetz: Der Markt für Raumintelligenz (VAS, VANS) : eine marktökonomische Analyse. Bayreuth: Verlag P.C.O., 1991.

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Slee, Carry. Vals. Wyd. 5. Amsterdam: Slee, 2006.

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Trabal, Francesc. Vals. Barcelona: Quaderns Crema, 1998.

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Bottomer, Paul. Vals. Madrid: Susaeta Ediciones, 1999.

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Francesc, Trabal. Vals. Barcelona: Quaderns Crema, 1998.

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Niele, Heleen. Vals. Amsterdam: Cargo, 2010.

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Vries, Mel Wallis de. Vals. Baarn: De Fontein, 2010.

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Khayal, Amin. Vafa. Lahore: Maqsud, 9999.

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Dhārāṇī, Sūmjī. Megh vans mālhā: Megh-vans malha. D̤īplo, Tharpārkar: Dharaṇī Pablīkeshani, 2015.

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Samad, Asror. Vafo vozhiblari. Toshkent: Fan, 2007.

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Części książek na temat "Vafs"

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Scharf, Kurt. "Vafi, Faribā". W Kindlers Literatur Lexikon (KLL), 1. Stuttgart: J.B. Metzler, 2020. http://dx.doi.org/10.1007/978-3-476-05728-0_22363-1.

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Offit, Paul A., Anne Snow, Thomas Fernandez, Laurie Cardona, Elena L. Grigorenko, Carolyn A. Doyle, Christopher J. McDougle i in. "Vineland, VABS". W Encyclopedia of Autism Spectrum Disorders, 3284. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4419-1698-3_101521.

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Pfannschmidt, Joachim. "Videothorakoskopie (VATS)". W Thoraxchirurgie, 1–12. Berlin, Heidelberg: Springer Berlin Heidelberg, 2022. http://dx.doi.org/10.1007/978-3-662-59159-8_21-1.

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Pfannschmidt, Joachim. "Videothorakoskopie (VATS)". W Thoraxchirurgie, 201–12. Berlin, Heidelberg: Springer Berlin Heidelberg, 2023. http://dx.doi.org/10.1007/978-3-662-59146-8_21.

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Smith, Paul. "Vas". W Feminisms, 1011–29. London: Macmillan Education UK, 1991. http://dx.doi.org/10.1007/978-1-349-22098-4_54.

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Rocco, Gaetano. "VATS Wedge Resection". W Chest Surgery, 115–22. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-12044-2_11.

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Bianchi, Massimo, Roland Allen, Antonio Mondragon, Alexander Gavrilik, John Howie, Martin Schlichenmaier, Martin Schlichenmaier i in. "Dijkgraaf-Vafa Theory". W Concise Encyclopedia of Supersymmetry, 128. Dordrecht: Springer Netherlands, 2004. http://dx.doi.org/10.1007/1-4020-4522-0_158.

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Hoffmann, Hans. "VATS Surgical Techniques". W Principles and Practice of Interventional Pulmonology, 639–51. New York, NY: Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4614-4292-9_62.

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Etherington-Wright, Christine. "Nurses and VADs". W Gender, Professions and Discourse, 54–69. London: Palgrave Macmillan UK, 2009. http://dx.doi.org/10.1057/9780230595026_4.

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Fujita, Isac K., i Sergio Y. Araki. "Optics and VADs". W Bioengineering and Biomaterials in Ventricular Assist Devices, 325–33. Boca Raton: CRC Press, 2021. http://dx.doi.org/10.1201/9781003138358-18.

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Streszczenia konferencji na temat "Vafs"

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Matthews, Ed, i Greg Burns. "VADS APSE". W the first international symposium. New York, New York, USA: ACM Press, 1991. http://dx.doi.org/10.1145/112629.112638.

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Burke, Robin, Gediminas Adomavicius, Ido Guy, Jan Krasnodebski, Luiz Pizzato, Yi Zhang i Himan Abdollahpouri. "VAMS 2017". W RecSys '17: Eleventh ACM Conference on Recommender Systems. New York, NY, USA: ACM, 2017. http://dx.doi.org/10.1145/3109859.3109957.

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Hartert, M., J. Tripsky i M. Hürtgen. "Subxiphoid VATS Thymectomy". W DACH-Jahrestagung Thoraxchirurgie. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-1694124.

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Wilk, Stefan, Denny Stohr i Wolfgang Effelsberg. "VAS". W the 25th ACM Workshop. New York, New York, USA: ACM Press, 2015. http://dx.doi.org/10.1145/2736084.2736092.

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Greif, B., i B. Vidmar. "Uniportal vats lobectomy – is it really more complicated than multiportal vats?" W DACH-Jahrestagung Thoraxchirurgie. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-1694173.

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Mardanzai, K., T. Plönes, B. Hegedüs, M. Zaatar, L. Langehegermann, D. Theegarten, M. Schuler, K. Darwiche, C. Taube i C. Aigner. "Lymphknotenupstaging nach uniportaler VATS Lobektomie". W DACH-Jahrestagung Thoraxchirurgie. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-1694170.

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Kim, Daeryong, i Bongwon Suh. "Enhancing VAEs for collaborative filtering". W RecSys '19: Thirteenth ACM Conference on Recommender Systems. New York, NY, USA: ACM, 2019. http://dx.doi.org/10.1145/3298689.3347015.

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Rodríguez, Pedro, Daniel Gallego, Javier Cerviño, Fernando Escribano, Juan Quemada i Joaquín Salvachúa. "VaaS: Videoconference as a service". W 5th International ICST Conference on Collaborative Computing: Networking, Applications, Worksharing. IEEE, 2009. http://dx.doi.org/10.4108/icst.collaboratecom2009.8285.

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Farias, Edson, Vinicius Mazetto Leandro i Matheus Scarduelli Luiz. "Structural Vans and its advantages". W 11th SAE BRASIL International Colloquium of Road Suspensions and Implements & Engineering Exhibition. 400 Commonwealth Drive, Warrendale, PA, United States: SAE International, 2021. http://dx.doi.org/10.4271/2020-36-0423.

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Jarma, Yesid, Golnaz Karbaschi, Marcelo Dias de Amorim, Farid Benbadis i Guillaume Chelius. "VAPS: Positioning with spatial constraints". W 2009 IEEE International Symposium on "A World of Wireless, Mobile and Multimedia Networks" (WowMoM). IEEE, 2009. http://dx.doi.org/10.1109/wowmom.2009.5282485.

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Raporty organizacyjne na temat "Vafs"

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Christiano, Lawrence, Martin Eichenbaum i Robert Vigfusson. Assessing Structural VARs. Cambridge, MA: National Bureau of Economic Research, lipiec 2006. http://dx.doi.org/10.3386/w12353.

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Horsleben Petersen, René. VATS Right Upper Lobectomy. Touch Surgery Simulations, maj 2021. http://dx.doi.org/10.18556/touchsurgery/2021.s0182.

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Onaitis, Mark W. Thoracic VATS LLL Superior Segmentectomy. Touch Surgery Simulations, lipiec 2021. http://dx.doi.org/10.18556/touchsurgery/2021.s0186.

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McCracken, Michael W., i Todd E. Clark. Averaging Forecasts from VARs with Uncertain Instabilities. Federal Reserve Bank of St. Louis, 2008. http://dx.doi.org/10.20955/wp.2008.030.

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Moon, Hyungsik Roger, Frank Schorfheide, Eleonora Granziera i Mihye Lee. Inference for VARs Identified with Sign Restrictions. Cambridge, MA: National Bureau of Economic Research, czerwiec 2011. http://dx.doi.org/10.3386/w17140.

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Drautzburg, Thorsten, i Jonathan Wright. Refining Set-Identification in VARs through Independence. Cambridge, MA: National Bureau of Economic Research, październik 2021. http://dx.doi.org/10.3386/w29316.

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Owyang, Michael T., i Howard J. Wall. Regional VARs and the Channels of Monetary Policy. Federal Reserve Bank of St. Louis, 2006. http://dx.doi.org/10.20955/wp.2006.002.

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Min, I. A. Puff Dispersion Sigma Values from MVP4 at VAFB. Fort Belvoir, VA: Defense Technical Information Center, czerwiec 2000. http://dx.doi.org/10.21236/ada387101.

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Oldenborger, G. A. Electrical resistivity surveys, Vars-Winchester esker aquifer, Ontario. Natural Resources Canada/CMSS/Information Management, 2021. http://dx.doi.org/10.4095/328037.

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Valverde, Alvaro. Information and communication technologies for improving investment readiness of small and medium agribusinesses. Commercial Agriculture for Smallholders and Agribusiness (CASA), 2020. http://dx.doi.org/10.1079/20240191164.

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Information and communication technologies (ICTs) are increasingly seen as an enabler to improve and promote efficiencies in global food market systems, and the high penetration rate of mobile phones is playing a catalytic role in developing countries. Mobile-based agriculture-value-added services (agri-VAS) aim to mitigate the information, financial and market access gaps faced by smallholder farmers and agribusinesses in developing countries. Over the last two decades, the number and variety of agri-VAS has been continuously increasing, and their landscape has been evolving. However, many agri-VAS never reach financial sustainability or scale and are discontinued after a few years. Increasing efforts are being made to map the landscape of agri-VAS targeted at smallholder farmers across Africa and Asia. However, insufficient attention has been paid to exploring successful agri-VAS that have small and medium (SME) agribusinesses as their main clients and that source from smallholder farmers. Areas with potential for further study include the following: (a) agribusinesses operating in value chains that are digitized by others (e.g. mobile network operators); (b) agribusinesses that are developing and deploying agri-VAS in-house; (c) agribusinesses using services provided by third-party agri-VAS providers within their value chains; and (d) agribusinesses that develop partnerships with agri-VAS providers to co-develop solutions. This study aims to address the following question: What are the factors behind successful deployment of mobile technologies to improve agribusiness productivity and investment readiness? It aims to analyse agri-VAS that have SME agribusinesses as their main clients, as they are more likely to positively impact the investment readiness of SME agribusinesses than agri-VAS with smallholder farmers as their only clients, which are also the most evaluated type of agri-VAS. The study consists of a combination of secondary and primary research, resulting in: (a) a set of investment-policy and service-design recommendations, based on high-impact, sustainable agribusiness-focused VAS; (b) recommendations on how to improve the body of impact evidence; and (c) the identification of investment opportunities at the agribusiness and agri-VAS levels.
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