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Artykuły w czasopismach na temat "United Palace (New York, N.Y.)"

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Greenwold, Diana. "“The Great Palace of American Civilization”: Allen Eaton’s Arts and Crafts of the Homelands, 1919-1932". Contemporaneity: Historical Presence in Visual Culture 3 (5.06.2014): 98–116. http://dx.doi.org/10.5195/contemp.2014.56.

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Allen Eaton’s Arts and Crafts of the Homelands exhibition premiered in Buffalo, New York in 1919, where it drew record crowds to the Albright Gallery. Iterations of the display soon opened in Albany, Rochester, and then in several other cities across the United States. Arts and Crafts of the Homelands showcased European craftwork of local immigrant groups to celebrate a model of early twentieth-century American pluralism. This article examines the aims of exhibit organizers, immigrant presenters, and native-born visitors to these exhibitions. The structure of the displays—which highlighted domestic tableaux of old-world objects—obfuscated the contemporary contributions of immigrant groups to American cultural and economic forums. I argue, however, that local groups took advantage of the exhibit’s performance spaces to assert their active presence in American public life.
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Hoefer, Dina, Patricia S. Ruppert, Elizabeth Rausch-Phung, Elizabeth Dufort, Manisha Patel, Manisha Patel, Dylan Johns i in. "LB15. Measles Outbreak in New York State (NYS) Outside of New York City, 2018–2019". Open Forum Infectious Diseases 6, Supplement_2 (październik 2019): S999—S1000. http://dx.doi.org/10.1093/ofid/ofz415.2498.

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Abstract Background The United States is experiencing one of the largest and longest measles outbreaks since elimination was declared in 2000 and is at risk of losing this status. Most cases occurring in NYS were reported in undervaccinated communities. Methods We included all confirmed NYS measles cases (excluding NYC) from outbreak counties from October 1, 2018 to July 25, 2019. We used the CSTE measles case definition requiring an acute febrile rash illness and either laboratory confirmation or direct epidemiologic linkage to a lab-confirmed case. For each case, demographic and clinical characteristics were obtained. A medical record review was completed for those reported to have an encounter at a hospital, emergency department, or urgent care center. Results There were 371 cases of measles reported, including 11 internationally imported cases. Most occurred in Rockland county (n = 283); followed by Orange (n = 55), Westchester (n = 18), Sullivan (n = 14) and Greene (n = 1) (Figures 1 and 2). The median age was 5.5 years; 79% of all cases occurred among children younger than 18 years of age (Figure 3). Most cases (79%) had not received any doses of measles vaccine. Of the 371 cases, 263 (71%) were children who had received 0 doses of measles, mumps, rubella vaccine (MMR), 218 (83%) of whom were over 1 year of age (Table 1). There have been no deaths or documented cases of encephalitis. Twenty-eight (8%) patients were diagnosed with pneumonia and 25 (7%) patients were hospitalized. Among 17 hospitalized children, 5 (29%) were admitted to the intensive care unit (ICU) (ages 1 day to 7 years). There were two preterm births at 34 and 25 weeks gestation to women with measles while pregnant. During October 1, 2018–July 31, 2019, providers in outbreak counties vaccinated 72,465 individuals with MMR, a 46% increase from the same period the year prior. Conclusion Unvaccinated children were identified as the largest group affected and experienced severe complications; nearly 30% of hospitalized children were admitted to an ICU. These data support the critical need for continued education and outreach on the risks of measles and the value of vaccination to prevent continued circulation in undervaccinated communities and potential further cases of severe disease. Disclosures Kirsten St. George, MAppSc, PhD, Akonni Biosystems (Other Financial or Material Support), ThermoFisher (Grant/Research Support), Zeptometrix (Other Financial or Material Support, royalty generating collaborative agreement); others, no disclosures reported..
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VАRENTSOVA, Larisa Yu. "PALACE AGRICULTURE IN RUSSIA IN THE 17TH CENTURY". Tyumen State University Herald. Humanities Research. Humanitates 6, nr 3 (2020): 118–36. http://dx.doi.org/10.21684/2411-197x-2020-6-3-118-136.

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Throughout the 17th century, the Palace economy developed dynamically in the Royal fiefdoms, which by the middle — the second half of the 17th century were characterized by high profitability. The Palace lands provided the Romanov House with everything it needed. The components of the Palace economy included agriculture, fishing grounds, and manufacturing facilities. At the same time, the Royal manufactories were not numerous, the fishing grounds were not in all the sovereign’s fiefdoms, only agriculture dominated everywhere. The relevance of this work lies in studying the historical experience of socio-econo­mic and political development of the Russian state in the 17th century. The purpose of the article is to consider Palace agriculture in Russia in the 17th century. The methodological basis of the study relies on the principles of historicism and scientific objectivity. The author has used the works by russian pre-revolutionary historians V. N. Tatishchev, S. M. Solovyov, and M. Baranovsky, as well as the works of researchers of the soviet and post-soviet periods S. I. Volkov, V. I. Buganov, V. A. Korostelev, and A. V. Topychkanov. The novelty of the research consists in the introduction of new historical sources into scientific circulation. The source database consists of the unpublished office documents from the Armory chamber fund 396, the Palace department fund 1239 of the Russian State Archive of Ancient Acts (RGADA, Moscow), as well as from the rare handwritten and old-printed books fund of the Moscow state United art historical, architectural and natural landscape museum-reserve. Among the published sources, we can distinguish a group of office documents. These are census, parish, and expense books of orders of Secret Affairs and the Grand Palace. In addition, the author has used the historical and geographical materials of the 17th — early 18th century from the books of the Discharge Order and the memoirs by the german traveler A. Oleary. The results show the place of Palace agriculture in the economy of the Tsar’s domain in Russia in the 17th century. The author has identified the main directions in the development of agriculture on the territory of the Palace fiefdoms. Having studied the attempt to modernize the Palace agriculture during the reign of Tsar Alexei Mikhailovich and to use the best european experience, this research highlights the significance of the Secret Affairs Order, which was in charge of many agricultural objects in the second half of the 17th century; their geographical coordinates are indicated. The author reveals the main features of the development of Palace grain farming, horticulture, animal husbandry, poultry farming, and beekeeping. The examples of farming in some Tsar’s villages of the Moscow Region showcase the ways of providing labor for the main objects of agriculture in the Tsar’s domain. The agricultural products from the Royal fiefdoms were intended for the Royal family. To a lesser extent, they were sent for sale on the domestic market. Different Royal fiefdoms specialized in particular fields. Namely, Izmailovo, Chashnikovo, Alekseevskoye, Stepanovskoye, Ekaterininskaya Grove, and Yermolino Palace villages near Moscow supplied rye, oats, wheat, hops, flax, and hemp. Grape, fruit, and mulberry orchards were bred in Chuguev, Astrakhan, Bryansk, and the Moscow Region. Russian and German specialists were involved in their service. The Palace villages Pachino, Alekseevskoe, Stepanovski, Ermolino, situated near Moscow, and the villages Lyskovo and Murashkino near Nizhny Novgorod were the centres of the Palace livestock. Tsar’s apiaryies were in Karpovka, Volnovsky, Kharkiv, Chuguyev, Olesinska, and Hotnichescom counties. Palace agriculture was served using the forced labor of palace peasants and posadsky people, soldiers, archers, while only small amounts of hired labor were involved.
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Nathan, Joseph P., i Sara Grossman. "Professional Reading Habits of Pharmacists Attending 2 Educational Seminars in New York City". Journal of Pharmacy Practice 25, nr 6 (25.07.2012): 600–605. http://dx.doi.org/10.1177/0897190012451930.

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Purpose: Data regarding the professional reading habits of pharmacists in the United States are lacking. The purpose of this pilot study was to investigate whether pharmacists read professional publications and assess other aspects of their professional reading habits. Methods: In December 2010, surveys were distributed to pharmacists participating in 2 educational seminars in New York City. The main outcome measures were percentages of pharmacists who read regularly (at least monthly), specific publications read, and the perceived value and impact of reading. Results: A total of 184 pharmacists were surveyed. Of the 122 (66%) respondents, 112 (92%) reported reading professional publications regularly. Of these, 97 (87%) indicated the titles read, with the 4 publications reported most frequently being Drug Topics (n = 73; 75%), Pharmacy Times (n = 67; 69%), US Pharmacist (n = 60; 62%), and Pharmacist’s Letter (n = 48; 49%). All 122 respondents indicated that reading positively impacted their practice, and 121 (99%) reported that reading was important. Conclusions: The value of reading professional publications was recognized by surveyed pharmacists; this likely contributed to the high reading rate reported in this study.
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Hoepting, C. A., H. F. Schwartz i H. R. Pappu. "First Report of Iris yellow spot virus on Onion in New York". Plant Disease 91, nr 3 (marzec 2007): 327. http://dx.doi.org/10.1094/pdis-91-3-0327a.

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Iris yellow spot virus (IYSV [family Bunyaviridae, genus Tospovirus]), a potentially devastating disease of onion vectored by onion thrips (Thrips tabaci Lindeman), has been reported from most states in the western United States where significant onion production occurs, with the most recent report from Texas (1). In June 2006, volunteer onion (Allium cepa) plants in Orleans County, New York (Elba muckland) were found to have symptoms indicative of IYSV infection. The scapes (seed stalks) of the volunteer onions found at the edge of a cull pile from a 2005 onion crop exhibited diamond-shaped lesions, each with a distinct green center and a double yellow border. Approximately 25 of 100 plants of red and yellow onion cultivars exhibited characteristic IYSV lesions. The cull pile was composed primarily of locally grown onions, although a few of the bulbs were grown from imported bare-root transplants imported from Arizona. Symptomatic plants tested positive for IYSV using IYSV-specific antiserum from Agdia Inc. (Elkhart, IN) in a double-antibody sandwich-ELISA. The presence of IYSV was verified by reverse transcription (RT)-PCR using primers derived from the small RNA of IYSV (S-RNA). The primers flanked the IYSV nucleocapsid (N) gene (5′-TAA AAC AAA CAT TCA AAC AA-3′ and 5′-CTC TTA AAC ACA TTT AAC AAG CAC-3′ (3). RT-PCR assays produced a PCR amplicon of expected size (approximately 1.2 kb) and the product was cloned and sequenced. Nucleotide sequence analysis confirmed the identity of the amplicon as that of the IYSV S-RNA. Sequence comparisons showed 95 to 98% identity with known IYSV N gene sequences available in GenBank. The virus is poorly transmitted to onion by mechanical inoculation and we did not have access to a noninfested colony of the onion thrips vector to transfer the virus from these samples to noninfected onions. No asymptomatic plants were tested. Among the onion-growing states in the eastern United States, IYSV has previously only been reported from Georgia (2). To our knowledge, this is the first report of IYSV in New York and the greater northeastern United States. The finding of this disease in New York confirms further spread of the virus within North America and the need for research to develop more effective management options to reduce the impact of IYSV on onion crops. References: (1) M. Miller et al. Plant Dis. 90:1359, 2006. (2) S. W. Mullis et al. Plant Dis. 90:377, 2006. (3) H. R. Pappu et al. Arch. Virol. 151:1015, 2006.
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Brown, William P., Marion E. Zuefle i Jason J. Dombroskie. "The effect of twig diameter on emergence rates of the oak twig pruner (Coleoptera: Cerambycidae)". Canadian Entomologist 148, nr 6 (16.06.2016): 693–97. http://dx.doi.org/10.4039/tce.2016.25.

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AbstractOak twig pruner (Anelaphus parallelus(Newman); Coleoptera: Cerambycidae) larvae develop inside twigs pruned from host plants. Reasons for this behaviour are unknown and differential emergence due to twig diameter has not been explored. Twigs pruned from walnuts (Juglans nigraLinnaeus; Juglandaceae) (n=179) and oaks (QuercusLinnaeus; Fagaceae) (n=84) were collected in Pennsylvania, United States of America in 2010; 118 pruned oak twigs were collected in New York State, United States of America in 2012. Twigs from 2012 were dissected to determine rates of emergence and larval mortality; both samples were examined for parasitoids. As the diameter of oak twigs (range of 3–16 mm) increased, larval mortality increased and adult emergence decreased. Date of collection did not influence twig diameter nor emergence rates. Three new parasitoids were associated with the oak twig pruner:AtanycolusFörster (Hymenoptera: Braconidae),Eubazus denticulatus(Martin) (Hymenoptera: Braconidae), and a potentially new genus of wasp (Hymenoptera: Braconidae, Hormiinae nearPambolusHaliday). Parasitism rates were an order of magnitude greater among twigs that contained more than one larva or pupa (23.1%;n=26) compared to those that contained only one (2.3%;n=341).
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Malapi-Wight, M., J. B. Hébert, R. Buckley, M. L. Daughtrey, N. F. Gregory, K. Rane, S. Tirpak i J. A. Crouch. "First Report of Boxwood Blight Caused byCalonectria pseudonaviculatain Delaware, Maryland, New Jersey, and New York". Plant Disease 98, nr 5 (maj 2014): 698. http://dx.doi.org/10.1094/pdis-10-13-1102-pdn.

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Boxwood (Buxus spp.) are commercially important evergreen ornamental plants with an annual market value of over $103 million in the United States. The recent U.S. incursion of boxwood blight disease caused by the fungus Calonectria pseudonaviculata (syn. Cylindrocladium pseudonaviculatum, Cy. buxicola) threatens the health and productivity of boxwood in both landscape plantings and nurseries. The first confirmed U.S. reports of the disease were made from Connecticut and North Carolina in November 2011 (2,4), followed by diagnoses in 10 additional states during 2012 and 2013. By August 2013, symptoms consistent with boxwood blight had been observed from B. sempervirens in Delaware, Maryland, New Jersey, and southeastern New York. Affected plants showed rapid onset of disease symptoms: dark brown to black spots or diffuse dark areas on leaves, followed by defoliation. Narrow, elongate black cankers also formed on current season shoots. Symptomatic stems and leaves were placed in petri dishes with moistened filter paper at 22°C for 3 days under continuous light. Conidiophores were excised, then placed on potato dextrose agar amended with streptomycin and neomycin (0.3 g/l). Resultant colonies showed dark brown pigmentation at the colony center surrounded by tan to reddish brown rings with white mycelia at the advancing edge. Conidia (n = 30 per isolate) were hyaline, cylindrical, rounded at both ends, with a single septum (45 to 76 × 4 to 6 μm; avg. 63 × 5 μm). Conidiophores (n = 20 per isolate) comprised a stipe, a hyaline septate stipe extension (length 119 to 192 μm; avg. 150 μm) and a terminal ellipsoidal vesicle (diameter 4 to 10 μm; avg. 7 μm). Based on morphological characteristics, the causal agent was identified as C. pseudonaviculata (1,4). Voucher specimens were deposited in the U.S. National Fungus Collections (BPI 892698 to 701). To verify morphological diagnosis, genomic DNA was extracted from fungal biomass grown in liquid cultures of yeast extract peptone dextrose media. A portion of the β-tubulin gene (TUB2) was PCR amplified and sequenced bi-directionally using primers Bta/Bt2b (3). BLASTn searches of NCBI GenBank databases using the TUB2 sequences (Accession Nos. KF785808 to 11) demonstrated 96 to 100% sequence identity with other C. pseudonaviculata isolates. To confirm pathogenicity, 5-month-old B. sempervirens and B. microphylla seedlings were spray-inoculated with a spore suspension of 1 × 104conidia/ml. One isolate from each state was independently tested with four replicates each. Non-inoculated water-sprayed plants served as negative controls. Plants were maintained in growth chambers at 22°C under constant light. Blight symptoms developed 4 to 5 days post inoculation. C. pseudonaviculata was re-isolated from inoculated plants; no symptoms or signs were observed from control plants. To our knowledge, this is the first report of C. pseudonaviculata in the states of Delaware, Maryland, New Jersey, and New York. This report demonstrates that C. pseudonaviculata is now widespread across the United States eastern seaboard, and represents a substantial threat to boxwood plants in North American landscapes and nurseries.References: (1) P. Crous et al. Sydowia 54:23, 2002. (2) D. F. Farr and A. Y. Rossman. Fungal Databases, USDA-ARS. Retrieved from http://nt.ars-grin.gov/fungaldatabases , 30 August 2013. (3) N. L. Glass and G. C. Donaldson. Appl. Environ. Microbiol. 61:1323, 1995. (4) K. L. Ivors et al. Plant Dis. 96:1070, 2012.
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Banner, Lois W. ":An Emotional History of the United States . Edited by Peter N. Stearns and Jan Lewis ( New York , New York University Press , 1998 ) 476 pp. $60 cloth $22.50 paper". Journal of Interdisciplinary History 30, nr 3 (styczeń 1999): 546–47. http://dx.doi.org/10.1162/jinh.1999.30.3.546.

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Banner, Lois W. "An Emotional History of the United States. Edited by Peter N. Stearns and Jan Lewis (New York, New York University Press, 1998) 476 pp. $60 cloth $22.50 paper". Journal of Interdisciplinary History 30, nr 3 (styczeń 2000): 546–47. http://dx.doi.org/10.1162/jinh.2000.30.3.546.

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LACHANCE-McCULLOUGH, MALCOLM L., JAMES M. TESORIERO, MARTIN D. SORIN i ANDREW STERN. "HIV Infection among New York State Female Inmates: Preliminary Results of a Voluntary Counseling and Testing Program". Prison Journal 74, nr 2 (czerwiec 1994): 198–219. http://dx.doi.org/10.1177/0032855594074002004.

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New York State's prison population has the highest seroprevalence of human immunodeficiency virus (HIV) among incarcerated populations in the United States. Five percent of the State prison inmate population is female. To date there have been few studies of incarcerated females in New York State (NYS). Seroprevalence rates have ranged from 18.9% to as high as 29%. In 1991, counselors from the New York State Department of Health (NYSDOH) AIDS Institute's Criminal Justice Initiative, in collaboration with the State's Department of Correctional Services (NYSDOCS), began to offer educational services and anonymous pretest counseling, HIV antibody testing, and posttest counseling to NYS female prisoners. With preliminary program testing data (N = 216) descriptive and multivariate techniques are used to evaluate the demographic and risk-related behaviors associated with HIV infection among female inmates in this voluntary HIV testing program. Results are discussed in light of previous research findings regarding the correlates of HIV seropositivity among New York State prison inmates and compared to previous blinded epidemiological studies of female inmates in the State. Future research, addressing the limitations of this preliminary study, is proposed.
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Rozprawy doktorskie na temat "United Palace (New York, N.Y.)"

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Boussac, Tamara. "Retour à Newburgh, New York : assistance sociale, fiscalité et bon gouvernement aux États-Unis (1945-1975)". Thesis, Paris, EHESS, 2020. http://www.theses.fr/2020EHES0113.

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A travers l'étude de l'affaire de Newburgh, NY, cette thèse met en lumière l'existence d'une contestation conservatrice de l'État-providence dans l'État de New York entre les années 1945 et 1975. Il s'agit ainsi d'écrire une histoire politique et sociale "par le bas" de l'opposition aux programmes d'assistance aux démunis dans le nord-est des États-Unis
This dissertation looks into the Newburgh, New York affair so as to unfold the existence a strong conservative critique of welfare programs in New York State between 1945 and 1975. It thus purports to write a social and political history of local and grassroots mobilizations against welfare in the liberal Northeast
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Książki na temat "United Palace (New York, N.Y.)"

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Annon, Adams, Levin Steven i Theatre Historical Society (U.S.), red. Loew's wonder theatres: Valencia, Queens, New York; Paradise, Bronx, New York; Kings, Brooklyn, New York; Jersey, Jersey City, New Jersey; 175th Street, New York, New York. Elmhurst, IL: Theatre Historical Society, 2002.

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Harrison, Colin, red. Palace of Treason: A Novel. New York City, New York, USA: Scribner, 2015.

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Asbury, Herbert. Bandy N £i Łu-I orka. Moskva: T ŁSentrpoligraf, 2004.

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Beaudry, Louis N. War journal of Louis N. Beaudry, Fifth New York Cavalry: The diary of a Union chaplain, commencing February 16, 1863. Jefferson, N.C: McFarland, 1996.

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Little Richard: The birth of rock 'n' roll. New York: Continuum International Publishing Group, 2009.

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Louie Louie: The history and mythology of the world's most famous rock 'n' roll song ... New York: Hyperion, 1993.

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Smith, A. P. History of the Seventy-Sixth Regiment New York Volunteers: What it endured and accomplished; containing descriptions of its twenty-five battles; its marches; its camp and bivouac scenes; with biographical sketches of fifty-three officers,and a complete record of the enlisted men. Gaithersburg, Md: Ron R. Van Sickle Military Books, 1988.

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Krizner, L. J. Peter Stuyvesant: New Amsterdam and the origins of New York. New York: PowerPlus Books, 2001.

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McKee, James Harvey. Back "in war times": History of the 144th Regiment, New York Volunteer Infantry, with itinerary, showing contemporaneous dates of the important battles of the Civil War. New York: H.E. Bailey, 1987.

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Brainard, Mary Genevie Green. Campaigns of the One Hundred and Forty-Sixth Regiment, New York State Volunteers: Also known as Halleck's Infantry, the Fifth Oneida, and Garrard's Tigers. New York: G.P. Putnam, 1988.

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Części książek na temat "United Palace (New York, N.Y.)"

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Bix, Brian H. "C". W A Dictionary of Legal Theory, 29–48. Oxford University PressOxford, 2004. http://dx.doi.org/10.1093/oso/9780199244621.003.0003.

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Abstract Cardozo, Benjamin N. Benjamin Nathan Cardozo (1870-1938), influenced American law both through his thoughtful and well-crafted opinions while a judge and by his writings about the judicial process. While Cardozo served both on the highest court of New York State, the New York Court of Appeals, and on the United States Supreme Court, most of his well-known opinions, paradoxically, are from the New York court. Cardozo ’s most important book is arguably The Nature of the judicial Process (1921), in which he presents the judicial role as a creative part of a process for making law serve social needs. While such views may seem commonplace now, they went against the formalist views prominent at the time, but were consistent with many of the ideas being put forward by the American legal realists.
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Tammemagi, Hans. "Case Histories". W The Waste Crisis. Oxford University Press, 2000. http://dx.doi.org/10.1093/oso/9780195128987.003.0014.

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Theory is fine, but practical experience is the heart of real learning. This chapter provides—as much as a book can—some real-life experience through seven case histories of how wastes are managed. The case histories describe a state-of-the-art materials recycling facility, five waste disposal facilities in three different countries (the United States, Canada, and Sweden), and a large mass-burn incinerator. Choosing which of the many thousands of landfills in existence to include was a difficult task. Three municipal solid waste landfills are described. The first, Fresh Kills landfill in New York City, was constructed in 1948 and represents older landfill technology. The second, a new landfill in East Carbon County, Utah, was built in 1992 and incorporates the latest engineered barriers and features of a modern landfill. The third is being developed in a large, abandoned open-pit mine in California. In addition, we discuss a landfill and treatment center for hazardous waste, located in Swan Hills, Alberta. A unique Swedish facility for disposing radioactive wastes rounds out the suite of landfill case histories; this facility takes a very innovative approach to waste disposal and is included to provide a different perspective on this topic. Materials recovery facilities (MRFs) are the vital heart of modern integrated municipal waste management systems. Without MRFs, recycling on any practical scale would not be possible; it is here that recyclable materials are collected and made ready for sale to secondary markets. One of the most innovative recycle centers in North America has recently been constructed in the city of Guelph in southern Ontario (Guelph, n,d.). It offers good insight into what can be achieved through recycling, and the equipment that is involved. The city of Guelph, with a population of 95,000, is situated about 60 kilometers west of Toronto. In the mid-1980s, the city began studying ways to reduce the amount of waste being placed in its landfill. These studies received a major impetus in 1991, when the province of Ontario developed a waste reduction plan that required municipalities to reduce the amount of garbage being placed in landfills by 50% by the year 2000. A number of pilot studies were conducted before the present approach was selected.
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Streszczenia konferencji na temat "United Palace (New York, N.Y.)"

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Lopes, Camila Galvão, Gabriele Campos, Jaqueline Wang, Ana Cristina Girardi i Maria Rita Passos Bueno. "Characterization of de novo variants in exomes of individuals with autism spectrum disorder". W XIV Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2023. http://dx.doi.org/10.5327/1516-3180.141s1.564.

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The main objective of this essay was to contribute to the characterization of the genetic architecture of autism spectrum disorder (ASD) based on an analysis of a Brazilian series, which is still little studied. To achieve this goal, we verified the proportion of cases of ASD caused by de novo variants in neurodevelopment genes (genes from the SFARI bank and those associated with neurodevelopment described in the DECIPHER bank). Sixty-three trios were evaluated, composed of parents and probands diagnosed with ASD treated at the Human Genome and Stem Cell Studies Center (CEGH-CEL, USP). Genealogy, clinical data, gender, age at the consultation, and parental age were collected. Whole-exome sequencing was performed through a collaboration with Mount Sinai, New York, United States (collaboration with the Autism Sequencing ConsortiumACS). Identification of De novo variants in candidate genes for ASD was performed using the LOVD program (LOVD v.3.0 – Leiden Open Variation Database). It was observed that most of the probands were boys (n = 55, 86%), and the minority had a family history of ASD (n = 4, 6%). It was also found that 40% (n = 25) of individuals had a delay in language development, and a small percentage had comorbidities such as ADHD and epilepsy (n=6, 10% and n=2, 3%, respectively). The mean parental age at the time of pregnancy was close to 30 years for both parents (29.7 and 32.5 for the mother and father, respectively). Nine de novo pathogenic or potentially pathogenic variants were identified in candidate genes: for TEA: six in SFARI genes (four pathogenic variants in NF1, TLK2, DNAH17, BRSK2 genes, and two probably pathogenic variants in ARHGAP5 and HUWE1) and three in genes of neurodevelopment of DECIPHER (Deciphering Developmental Disorders Study, 2015) (two pathogenic variants in the ERLIN2, ST3GAL3 genes and one probably pathogenic in COL11A1). When performing the gene enrichment analysis of genes with pathogenic or potentially pathogenic variants, we observed the enrichment of genes for intracellular protein transport. The clinical picture of individuals with pathogenic or potentially pathogenic variants was expected, as previously described in the literature. This study suggests that de novo variants are also an essential mechanism for the etiology of ASD in Brazil, explaining the genetic architecture of 9.5% of cases.
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