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Wu, Hai Ying. "Usage Control Model Based on Regular Grammar". Advanced Materials Research 433-440 (styczeń 2012): 4590–96. http://dx.doi.org/10.4028/www.scientific.net/amr.433-440.4590.
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Traditional access control models through search Access Control List(ACL) to authorize [1-3]. Traditional access control models fail to satisfy the modern information system, thus Usage Control( UCON ) models were produced and fundamentally enhanced the traditional access control. The UCON models are considered as the next generation access control models. This paper is organized as follow. Section 1 introduces the Usage Control models. Section 2 introduces Regular Grammar ( RG ). Section 3 gives the RG of the 16 core ABC UCON models. Section 4 gives the RG of on-line antivirus procedure. Finally, section 5 summarizes this paper.
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Jiang, Ze Tao, i Jia Fei He. "Research on an UCON Extension Model Applicable to Industrial Control". Applied Mechanics and Materials 20-23 (styczeń 2010): 470–76. http://dx.doi.org/10.4028/www.scientific.net/amm.20-23.470.
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Although UCON makes a unified framework for research on modern access control, it is not applicable enough due to fact that it only gives out a conceptual model. In this paper, analysis and extension have been made on UCON, role and task factors are introduced to it and combined with the conception of domain, an UCON extension model—UCONTR model, which is applicable to industrial control, is proposed. Its formalized description is given in the next step. Finally, the application of UCONTR on distributed control system for heat treatment is introduced in detail.
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Gan, Sheng Ke, i Feng Bin Wang. "An Extended UCON Model Supporting Distributed Multidomain Applications". Advanced Materials Research 433-440 (styczeń 2012): 5616–19. http://dx.doi.org/10.4028/www.scientific.net/amr.433-440.5616.
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This paper presents security rules summarized from the analysis of an distributed multidomain application. The paper proposes extensions to the core UCON model to address typical problems and requirements in the distributed multidomain environment such as: dynamic attributes, delegation authorization mechanism. The paper gives the definition of the important part of the extended UCON model such as: the basic sets, the system assertions and the actions.
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Park, Jaehong, i Ravi Sandhu. "The UCON ABC usage control model". ACM Transactions on Information and System Security 7, nr 1 (luty 2004): 128–74. http://dx.doi.org/10.1145/984334.984339.
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Xu, Xiao Lin. "Research on Task-Based Usage Control Core Models in Workflow for Manufacturing Environment". Advanced Materials Research 886 (styczeń 2014): 378–81. http://dx.doi.org/10.4028/www.scientific.net/amr.886.378.
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With widespread application of Workflow (WF) management system, problem in access control becomes more and more important. At present, the TBAC Model and TRBAC Model cannot satisfy the requirements of access control in Modern information systems. Therefore, the task in WF is the center which combine UCON model with WF, and establish the Task-Based Usage Control (TUCON) Model in which the access control of WF use the UCON Model.
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Tang, Jia. "Research on Design of Network Platform Based on UCON Access Control Model". Applied Mechanics and Materials 543-547 (marzec 2014): 4589–92. http://dx.doi.org/10.4028/www.scientific.net/amm.543-547.4589.
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Network teaching as a new teaching methods, taking full advantage of computer, networking and multimedia technologies, making teaching behaviors across time and space constraints, has a great deal of flexibility and interactivity. However, access control is very important in network teaching platform, and it decides the security of such platform. In this paper, we analyze the UCON access control model in detail, propose a UCON based access control model, and design a network teaching platform with the proposed access control model.
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Chang, He, Yang Lu i Yantao Sun. "Simultaneous Prediction, Determination, and Extraction of Four Polycyclic Aromatic Hydrocarbons in the Environment Using a UCON–NaH2PO4 Aqueous Two-Phase Extraction System Combined with High-Performance Liquid Chromatography-Ultraviolet Detection". Molecules 27, nr 19 (30.09.2022): 6465. http://dx.doi.org/10.3390/molecules27196465.
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In this paper, a new aqueous two-phase extraction system(ATPES) consisting of UCON (poly(ethylene glycol-ran-propylene glycol) monobutyl ether)–NaH2PO4 was established, and four trace polycyclic aromatic hydrocarbons (PAHs: fluorene, anthracene, pyrene and phenanthrene) in water and soil were analyzed by high-performance liquid chromatography (HPLC)–ultraviolet detection. In the multi-factor experiment, the central composite design (CCD) was used to determine the optimum technological conditions. The final optimal conditions were as follows: the concentration of UCON was 0.45 g·mL−1, the concentration of NaH2PO4 was 3.5 mol·L−1, and the temperature was 30 °C. The recovery of the four targets was 98.91–99.84% with a relative standard deviation of 0.3–2.1%. Then UCON recycling and cyclic tests were designed in the experiment, and the results showed that the recovery of PAHs gradually increased in the three extractions because of the remaining PAHs in the salt phase of last extraction. The recovery of PAHs in the UCON recycling test was less than that in the extraction test due to the wastage of UCON. In addition, a two-phase aqueous extraction model was established based on the random forest (RF) model. The results obtained were compared with the experimental data, and the root mean square error (RMSE) was 0.0371–0.0514 and the correlation coefficient R2 was 96.20–98.53%, proving that the model is robust and reliable.
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Dai, Chang Ying, Wen Tao Gong i Jing Liu. "Access Process of Data-Flow in Cross-Domain Usage Control Model Based on XACML". Advanced Materials Research 143-144 (październik 2010): 1275–79. http://dx.doi.org/10.4028/www.scientific.net/amr.143-144.1275.
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With the rapid development of information technology, more and more requesters need accessing the services in different access domains, which make the access process in cross-domain become more difficultly. The traditional access control models couldn’t solve the access process for their design limitations and diversity access policies. Usage control model (UCON) was proposed to strengthen the expression of access control model, but UCON is only a conceptual model. How to use the UCON in access process? It is worthwhile to further study. Extensible access control markup language (XACML) is an open standard XML-based language, which can be used to describe the security policy. In order to solve the access process in different access domains, based on XACML, access process of data-flow in cross-domain usage control model is proposed in the paper. Access process of data-flow cross different domains in XACML is introduced to solve the cross-domain problem. Finally, a small example is given to verify the effectiveness of access process.
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Liu, Jing, Rongchao Liu i Yingxu Lai. "Risk-Based Dynamic Identity Authentication Method Based on the UCON Model". Security and Communication Networks 2022 (31.03.2022): 1–13. http://dx.doi.org/10.1155/2022/2509267.
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With the continuous progress of computer technology, static identity authentication technology has encountered challenges in practical applications; in addition, it has deficiencies in continuity and mutability. For these reasons, we propose a risk-based dynamic identity authentication method based on the Usage Control (UCON) model. When authenticating a user, we consider their access rights based on the degree of risk, except in case of password authentication. We propose a risk assessment method, and blockchain technology is used in the scheme to provide a reliable process for risk assessment and authorization. Our scheme represents an improvement in traditional identity authentication, resulting in higher continuity and mutability. We also prove that the scheme has high security and scalability.
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JASIM AL-FARTTOOSI, DAWOOD SALMAN. "Formal model and Policy specification for software defined networks". Journal of Kufa for Mathematics and Computer 3, nr 2 (30.12.2016): 55–62. http://dx.doi.org/10.31642/jokmc/2018/030207.
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Software-defined networking SDN is gaining a sharp increase in adoption by very well-known companies Like Google and Microsoft. Currently, the two stands out reliability and security are the most issues that hampering the SDN rapid growth. This paper aims to contribute to this growing area of research by exploring the SDN security issues. Novel approach will be proposed by utilizing the well-known access control approach called theusage control UCON model and also the Flog policy language of software defined networks SDNs. This work will be produced as a formal modelling via high-level abstract language like Flog
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Chang, Rui, Zhaowen Lin, Yi Sun i Jie Xu. "MD-UCON: A Multi-Domain Access Control Model for SDN Northbound Interfaces". Journal of Physics: Conference Series 1187, nr 3 (kwiecień 2019): 032091. http://dx.doi.org/10.1088/1742-6596/1187/3/032091.
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Gruijter, Dato N. M. "A Note on the Bias of UCON Item Parameter Estimation in the Rasch Model". Journal of Educational Measurement 27, nr 3 (wrzesień 1990): 285–88. http://dx.doi.org/10.1111/j.1745-3984.1990.tb00749.x.
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YE, Chun-xiao, i Yi-feng YU. "Safety analysis for UCONpreA model with delegation feature and expression for DBRM0". Journal of Computer Applications 32, nr 12 (30.05.2013): 3426–29. http://dx.doi.org/10.3724/sp.j.1087.2012.03426.
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Huang, Kun, i Yun Song Jian. "Research on a New Access Control Technology". Advanced Materials Research 765-767 (wrzesień 2013): 1858–62. http://dx.doi.org/10.4028/www.scientific.net/amr.765-767.1858.
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The term usage control (UCON)[1] is a generalization of access control to cover obligations, conditions, continuity (ongoing controls) and mutability. Traditionally, access control has dealt only with authorization decisions on a subject's access to target resources, and as a consequence of access have not been systematically studied. In this paper we motivate the need for usage control, study a family of ABC models as a core model for usage control and show how it encompasses traditional access control, such as mandatory, discretionary and role-based access control,. In addition, we also discuss architectures that introduce a new reference monitor for usage control and some variations.
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MYO, TAKAYUKI, HIROSHI TOKI i KIYOMI IKEDA. "TENSOR OPTIMIZED SHELL MODEL WITH UNITARY CORRELATION OPERATOR USING BARE INTERACTION FOR LIGHT NUCLEI". Modern Physics Letters A 24, nr 11n13 (30.04.2009): 847–50. http://dx.doi.org/10.1142/s0217732309000140.
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We propose a new theoretical approach to calculate nuclear structure using bare nuclear interaction, in which the tensor and short-range correlations are described by using the tensor optimized shell model (TOSM) and the unitary correlation operator method (UCOM), respectively. We compare the obtained results using TOSM+UCOM for 4 He with the rigorous calculation.
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Sadek, Nermeen B., Sarah M. Gamal, Basma E. Aboulhoda, Laila A. Rashed, Heba M. Shawky i Maha M. Gamal El-Din. "The Potential Role of Undercarboxylated Osteocalcin Upregulation in Microvascular Insufficiency in a Rat Model of Diabetic Cardiomyopathy". Journal of Cardiovascular Pharmacology and Therapeutics 25, nr 1 (18.09.2019): 86–97. http://dx.doi.org/10.1177/1074248419876632.
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Background: Diabetic cardiomyopathy (DCM) is accompanied by microvascular complications that lead to myocardial dysfunction and heart failure. Most conventional therapies cannot ameliorate the microvascular insufficiency in DCM. In this study, we tested the hypothesis that undercarboxylated osteocalcin (ucOC) may be a new adjuvant therapy against the progression of DCM and its underlying microvascular pathology. Materials and Methods: Diabetes was induced in Wistar rats with a high-fat diet combined with streptozotocin injections, and ucOC was upregulated after warfarin administration in the treated group. After 8 weeks, cardiac functions were assessed using a Langendorff apparatus. Cardiac tissue samples were also extracted to assess the ucOC receptor and vascular endothelial growth factor (VEGF) for histopathological studies. Results: Both the systolic and the diastolic dysfunction observed in the DCM group were significantly improved after the increase in ucOC blood levels. Significant improvement in VEGF and CD31 expression after warfarin injection was associated with increased capillary density, neovascularization, and decreased myocardial fibrosis together with the reestablishment of myocardial structural and ultrastructural patterns. Conclusion: Undercarboxylated osteocalcin may have a promising effect in improving microvascular insufficiency and myocardial dysfunction in DCM.
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Jiang, Wenyu, Meijiao Lu, Li Zhang, Chenjing Xu, Ruohan Wang, Ying Xu, Wen Tang i Hongjie Zhang. "Optimizing individualized management of patients with ulcerative colitis: Identification of risk factors predicting ulcerative colitis-associated neoplasia". Medicine 102, nr 32 (11.08.2023): e34729. http://dx.doi.org/10.1097/md.0000000000034729.
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The risk of developing colorectal neoplasia in patients with ulcerative colitis (UC) is increased. The purpose of this study is to analyze the risk factors of UC-associated neoplasia (UCAN) in UC patients and establish a clinical prediction model. 828 UC patients were included in this retrospective study. 602 patients were in discovery cohort and 226 patients were in validation cohort (internal validation cohort/external validation cohort: 120/106). Clinical and endoscopic data were collected. The discovery cohort was divided into UC group and UCAN group for univariate and multivariate binary logistic analyses. The UCAN clinical prediction model was established and verified. In the univariate analysis, 7 risk factors were related to UCAN. Multivariate logistic regression analysis showed that age at diagnosis of UC (OR: 1.018, 95% CI: 1.003–1.033), Ulcerative Colitis Endoscopic Index of Severity (UCEIS) score (OR: 1.823, 95% CI: 1.562–2.128), and size of polyps (size1: OR: 6.297, 95% CI: 3.669–10.809; size2: OR: 12.014, 95% CI: 6.327–22.814) were independent risk factors of UCAN. A mathematical equation was established. The area under the ROC curve (AUC) of this model was calculated to be 0.845 (95%CI: 0.809–0.881). The sensitivity was 0.884 and the specificity was 0.688. The AUC of internal validation cohort was 0.901 (95%CI: 0.815, 0.988), sensitivity was 75.0% and specificity was 92.6%. The AUC of external validation cohort was 0.842 (95%CI: 0.709, 0.976), sensitivity was 62.5% and specificity was 93.9%. This prediction model is simple, practical, and effective for predicting the risk of UCAN, which is beneficial to the individualized management of patients with UC.
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Lacombe, Julie, Omar Al Rifai, Lorraine Loter, Thomas Moran, Anne-Frédérique Turcotte, Thomas Grenier-Larouche, André Tchernof i in. "Measurement of bioactive osteocalcin in humans using a novel immunoassay reveals association with glucose metabolism and β-cell function". American Journal of Physiology-Endocrinology and Metabolism 318, nr 3 (1.03.2020): E381—E391. http://dx.doi.org/10.1152/ajpendo.00321.2019.
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Osteocalcin (OCN) is a bone-derived hormone involved in the regulation of glucose metabolism. In serum, OCN exists in carboxylated and uncarboxylated forms (ucOCN), and studies in rodents suggest that ucOCN is the bioactive form of this hormone. Whether this is also the case in humans is unclear, because a reliable assay to measure ucOCN is not available. Here, we established and validated a new immunoassay (ELISA) measuring human ucOCN and used it to determine the level of bioactive OCN in two cohorts of overweight or obese subjects, with or without type 2 diabetes (T2D). The ELISA could specifically detect ucOCN concentrations ranging from 0.037 to 1.8 ng/mL. In a first cohort of overweight or obese postmenopausal women without diabetes ( n = 132), ucOCN correlated negatively with fasting glucose (r = −0.18, P = 0.042) and insulin resistance assessed by the homeostatic model assessment of insulin resistance (r = −0.18, P = 0.038) and positively with insulin sensitivity assessed by a hyperinsulinemic-euglycemic clamp (r = 0.18, P = 0.043) or insulin sensitivity index derived from an oral glucose tolerance test (r = 0.26, P = 0.003). In a second cohort of subjects with severe obesity ( n = 16), ucOCN was found to be lower in subjects with T2D compared with those without T2D (2.76 ± 0.38 versus 4.52 ± 0.06 ng/mL, P = 0.009) and to negatively correlate with fasting glucose (r = −0.50, P = 0.046) and glycated hemoglobin (r = −0.57, P = 0.021). Moreover, the subjects with ucOCN levels below 3 ng/mL had a reduced insulin secretion rate during a hyperglycemic clamp ( P = 0.03). In conclusion, ucOCN measured with this novel and specific assay is inversely associated with insulin resistance and β-cell dysfunction in humans.
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MYO, TAKAYUKI, HIROSHI TOKI i KIYOMI IKEDA. "TENSOR OPTIMIZED SHELL MODEL USING BARE INTERACTION FOR LIGHT NUCLEI". Modern Physics Letters A 25, nr 21n23 (30.07.2010): 1985–88. http://dx.doi.org/10.1142/s0217732310000800.
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We propose a new method to describe nuclear structure using bare nuclear interaction, in which the tensor and short-range correlations are described by using the tensor optimized shell model (TOSM) and the unitary correlation operator method (UCOM), respectively.
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Ardwiansyah, Yogha, Achmad Tjahya Nugraha i Nunuk Adiarni. "PENERAPAN METODE BUSINESS MODEL CANVAS DAN PETA EMPATI PADA USAHA MIKRO KECIL DAN MENENGAH (UMKM) KEBAB DURIAN UCOK". Niagawan 12, nr 2 (3.07.2023): 118. http://dx.doi.org/10.24114/niaga.v12i2.46470.
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The research explores the development of a business model for UMKM Kebab Durian Ucok using business model canvas analysis, empathy maps, and gap analysis. As an MSME, Kebab Durian Ucok plays an important role in the national economy. Understanding the business model, customer needs, and identifying performance gaps is critical to Kebab Durian Ucok's continued growth and competitiveness.The study begins by providing an overview of the challenges faced by Kebab Durian Ucok as MSMEs in the food industry and emphasizing the importance of strategic planning in business. This study provides an overview and relevance of business model canvas analysis, empathy maps, and gap analysis of business competition.The research framework begins with digging up internal information related to the initial description of the strategy and business model that will produce a value proposition, then an analysis of customer insights with an empathy map is carried out to obtain information from the external side that will produce a customer value proposition, from these results a gap analysis is carried out. The gap is then used as material for evaluating the improvement of the strategy using the new business model canvas.The results obtained are in the form of nine block elements of the UMKM Kebab Durian Ucok canvas business model, the needs and desires of customers consisting of product taste, price suitability, product variety, fresh durian content, texture, and service, as well as the gap between the value proposition and the customer's value proposition. The gap is in the aspects of product attractiveness, information reach, price suitability, and service. The recommended business model strategy is the addition of value proposition, key activities, channels, and key partners element blocks.
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McAdams, Ryan M., Ronald J. McPherson, Raj P. Kapur i Sandra E. Juul. "Focal Brain Injury Associated with a Model of Severe Hypoxic-Ischemic Encephalopathy in Nonhuman Primates". Developmental Neuroscience 39, nr 1-4 (2017): 107–23. http://dx.doi.org/10.1159/000456658.
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Worldwide, hypoxic-ischemic encephalopathy (HIE) is a major cause of neonatal mortality and morbidity. To better understand the mechanisms contributing to brain injury and improve outcomes in neonates with HIE, better preclinical animal models that mimic the clinical situation following birth asphyxia in term newborns are needed. In an effort to achieve this goal, we modified our nonhuman primate model of HIE induced by in utero umbilical cord occlusion (UCO) to include postnatal hypoxic episodes, in order to simulate apneic events in human neonates with HIE. We describe a cohort of 4 near-term fetal Macaca nemestrina that underwent 18 min of in utero UCO, followed by cesarean section delivery, resuscitation, and subsequent postnatal mechanical ventilation, with exposure to intermittent daily hypoxia (3 min, 8% O2 3-8 times daily for 3 days). After delivery, all animals demonstrated severe metabolic acidosis (pH 7 ± 0.12; mean ± SD) and low APGAR scores (<5 at 10 min of age). Three of 4 animals had both electrographic and clinical seizures. Serial blood samples were collected and plasma metabolites were determined by 2-dimensional gas chromatography coupled with time-of-flight mass spectrometry (GC × GC-TOFMS). The 4 UCO animals and a single nonasphyxiated animal (delivered by cesarean section but without exposure to UCO or prolonged sedation) underwent brain magnetic resonance imaging (MRI) on day 8 of life. Thalamic injury was present on MRI in 3 UCO animals, but not in the control animal. Following necropsy on day 8, brain histopathology revealed neuronal injury/loss and gliosis in portions of the ventrolateral thalamus in all 4 UCO, with 2 animals also demonstrating putamen/globus pallidus involvement. In addition, all 4 UCO animals demonstrated brain stem gliosis, with neuronal loss present in the midbrain, pons, and lateral medulla in 3 of 4 animals. Transmission electron microscopy imaging of the brain tissues was performed, which demonstrated ultrastructural white matter abnormalities, characterized by perinuclear vacuolation and axonal dilation, in 3 of 4 animals. Immunolabeling of Nogo-A, a negative regulator of neuronal growth, was not increased in the injured brains compared to 2 control animals. Using GC × GC-TOFMS, we identified metabolites previously recognized as potential biomarkers of perinatal asphyxia. The basal ganglia-thalamus-brain stem injury produced by UCO is consistent with the deep nuclear/brainstem injury pattern seen in human neonates after severe, abrupt hypoxic-ischemic insults. The UCO model permits timely detection of biomarkers associated with specific patterns of neonatal brain injury, and it may ultimately be useful for validating therapeutic strategies to treat neonatal HIE.
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Chun, Pattaraporn T., Ronald J. McPherson, Luke C. Marney, Sahar Z. Zangeneh, Brendon A. Parsons, Ali Shojaie, Robert E. Synovec i Sandra E. Juul. "Serial Plasma Metabolites Following Hypoxic-Ischemic Encephalopathy in a Nonhuman Primate Model". Developmental Neuroscience 37, nr 2 (2015): 161–71. http://dx.doi.org/10.1159/000370147.
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Biomarkers that indicate the severity of hypoxic-ischemic brain injury and response to treatment and that predict neurodevelopmental outcomes are urgently needed to improve the care of affected neonates. We hypothesize that sequentially obtained plasma metabolomes will provide indicators of brain injury and repair, allowing for the prediction of neurodevelopmental outcomes. A total of 33 Macaca nemestrina underwent 0, 15 or 18 min of in utero umbilical cord occlusion (UCO) to induce hypoxic-ischemic encephalopathy and were then delivered by hysterotomy, resuscitated and stabilized. Serial blood samples were obtained at baseline (cord blood) and at 0.1, 24, 48, and 72 h of age. Treatment groups included nonasphyxiated controls (n = 7), untreated UCO (n = 11), UCO + hypothermia (HT; n = 6), and UCO + HT + erythropoietin (n = 9). Metabolites were extracted and analyzed using comprehensive two-dimensional gas chromatography coupled with time-of-flight mass spectrometry and quantified by PARAFAC (parallel factor analysis). Using nontargeted discovery-based methods, we identified 63 metabolites as potential biomarkers. The changes in metabolite concentrations were characterized and compared between treatment groups. Further comparison determined that 8 metabolites (arachidonic acid, butanoic acid, citric acid, fumaric acid, lactate, malate, propanoic acid, and succinic acid) correlated with early and/or long-term neurodevelopmental outcomes. The combined outcomes of death or cerebral palsy correlated with citric acid, fumaric acid, lactate, and propanoic acid. This change in circulating metabolome after UCO may reflect cellular metabolism and biochemical changes in response to the severity of brain injury and have potential to predict neurodevelopmental outcomes.
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McAdams, Ryan M., Bobbi Fleiss, Christopher Traudt, Leslie Schwendimann, Jessica M. Snyder, Robin L. Haynes, Niranjana Natarajan, Pierre Gressens i Sandra E. Juul. "Long-Term Neuropathological Changes Associated with Cerebral Palsy in a Nonhuman Primate Model of Hypoxic-Ischemic Encephalopathy". Developmental Neuroscience 39, nr 1-4 (2017): 124–40. http://dx.doi.org/10.1159/000470903.
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Background: Cerebral palsy (CP) is the most common motor disability in childhood, with a worldwide prevalence of 1.5-4/1,000 live births. Hypoxic-ischemic encephalopathy (HIE) contributes to the burden of CP, but the long-term neuropathological findings of this association remain limited. Methodology: Thirty-four term Macaca nemestrina macaques were included in this long-term neuropathological study: 9 control animals delivered by cesarean section and 25 animals with perinatal asphyxia delivered by cesarean section after 15-18 min of umbilical cord occlusion (UCO). UCO animals were randomized to saline (n = 11), therapeutic hypothermia (TH; n = 6), or TH + erythropoietin (Epo; n = 8). Epo was given on days 1, 2, 3, and 7. Animals had serial developmental assessments and underwent magnetic resonance imaging with diffusion tensor imaging at 9 months of age followed by necropsy. Histology and immunohistochemical (IHC) staining of brain and brainstem sections were performed. Results: All UCO animals demonstrated and met the standard diagnostic criteria for human neonates with moderate-to-severe HIE. Four animals developed moderate-to-severe CP (3 UCO and 1 UCO + TH), 9 had mild CP (2 UCO, 3 UCO + TH, 3 UCO + TH + Epo, and 1 control), and 2 UCO animals died. None of the animals treated with TH + Epo died, had moderate-to-severe CP, or demonstrated signs of long-term neuropathological toxicity. Compared to animals grouped together as having no CP (no-CP; controls and mild CP only), animals with CP (moderate and severe) demonstrated decreased fractional anisotropy of multiple white-matter tracts including the corpus callosum and internal capsule, when using Tract-Based Spatial Statistics (TBSS). Animals with CP had decreased staining for cortical neurons and increased brainstem glial scarring compared to animals without CP. The cerebellar cell density of the internal granular layer and white matter was decreased in CP animals compared to that in control animals without CP. Conclusions/Significance: In this nonhuman primate HIE model, animals treated with TH + Epo had less brain pathology noted on TBSS and IHC staining, which supports the long-term safety of TH + Epo in the setting of HIE. Animals that developed CP showed white-matter changes noted on TBSS, subtle histopathological changes in both the white and gray matter, and brainstem injury that correlated with CP severity. This HIE model may lend itself to further study of the relationship between brainstem injury and CP.
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Hu, Linmin, Wei Huang, Guofang Wang i Ruiling Tian. "Redundancy Optimization of an Uncertain Parallel-Series System with Warm Standby Elements". Complexity 2018 (6.09.2018): 1–10. http://dx.doi.org/10.1155/2018/3154360.
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The redundancy optimization problem is formulated for an uncertain parallel-series system with warm standby elements. The lifetimes and costs of elements are considered uncertain variables, and the weights and volumes of elements are random variables. The uncertain measure optimization model (UMOM), the uncertain optimistic value optimization model (UOVOM), and the uncertain cost optimization model (UCOM) are developed through reliability maximization, lifetime maximization, and cost minimization, respectively. An efficient simulation optimization algorithm is provided to calculate the objective values and optimal solutions of the UMOM, UOVOM, and UCOM. A numerical example is presented to illustrate the rationality of the models and the feasibility of the optimization algorithm.
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MYO, TAKAYUKI, KIYOSHI KATŌ, YUMA KIKUCHI, HIROSHI TOKI i KIYOMI IKEDA. "TENSOR CORRELATION IN He AND Li ISOTOPES BASED ON TENSOR OPTIMIZED SHELL MODEL WITH UNITARY CORRELATION OPERATOR". International Journal of Modern Physics A 24, nr 11 (30.04.2009): 2150–58. http://dx.doi.org/10.1142/s0217751x0904573x.
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We show the importance of the tensor correlation on the structures of He and Li isotopes. We develop the tensor optimized shell model (TOSM) to describe the strong tensor correlation of the nuclear force in nuclei. We investigate the exotic structures of 9,10,11 Li based on the 9 Li +n+n model where TOSM is used for 9 Li . The coupling between the tensor correlation in 9 Li and the extra two neutrons emerges Pauli-blocking, which increases the s2 component and develops the halo structure in 11 Li . We further treat the short range repulsion of the nuclear force by the unitary correlation operator method (UCOM), while the tensor correlation is described by TOSM. We propose a new approach of TOSM+UCOM to describe nuclei from the nuclear force.
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Esquivel-González, Xochitl, i Arturo Martínez-Cosme. "Intervención oportuna en prematuros extremos: dos casos tratados en Terapia Ocupacional, Toluca, México". Revista Terapéutica 15, nr 2 (23.07.2021): 63–70. http://dx.doi.org/10.33967/rt.v15i2.138.
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El “prematuro extremo” representa un gran reto en la Unidad de Cuidados Intensivos (UCIN), siendo prioridad la vida en dicho periodo. A su egreso de la UCIN, se enfrenta a un nuevo desafío. Se presentan dos casos de prematuros extremos de 26 semanas de gestación atendidos en el servicio de Terapia Ocupacional. El abordaje de intervención fue Neurodesarrollo y Modelo de Ocupación Humana, los indicadores de evaluación: Evaluación Neurológica para niños menores de cinco años en el primer y segundo nivel de atención, la Evaluación del Desarrollo Infantil (EDI) y Cuestionario Volicional Pediátrico (CVP) y la observación clínica. Promover el desempeño ocupacional en el niño posterior a una estancia prolongada en la UCIN, implica un reto en el abordaje, se debe buscar el proceso de interacción social, intencionalidad a través de la participación en experiencias con significado. En la actualidad, una de las metas para la consolidación de campos de conocimiento, atención y prospectiva es profundizar en la intervención que realiza el respectivo profesional en la UCIN.
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Fomin, Alexey, Anatolii Serebrov, Mikhail Chaikovskii, Oleg Zherebtsov, Aleksandr Murashkin i Elena Golubeva. "Plan of NNbar experiment at the WWR-M reactor". EPJ Web of Conferences 219 (2019): 07003. http://dx.doi.org/10.1051/epjconf/201921907003.
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We propose an experiment to search for neutron–antineutron oscillations based on the storage of ultracold neutrons (UCN) in a material trap. This experiment will be competitive due to a new UCN source which is under construction at the NRC “Kurchatov Institute” – PNPI. It is expected to provide UCN densities by 2–3 orders of magnitude higher than at existing sources. The sensitivity of our experiment mostly depends on the trap size and the stored number of UCN. Simulations show that this can be increased by ∼ 10–40 times compared to the best previous experiment, dependent upon a model of neutron reflection from walls. The project currently includes designs of the UCN chamber, magnetic shielding and the detector system, as well as simulations of neutron storage and detection of annihilations events.
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Naser, Amna, Ahmad Qasem i Saleh A. Naser. "Mycobacterial infection influences bone biomarker levels in patients with Crohn’s disease". Canadian Journal of Physiology and Pharmacology 96, nr 7 (lipiec 2018): 662–67. http://dx.doi.org/10.1139/cjpp-2017-0700.
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Patients with Crohn’s disease (CD) have higher risk for osteoporosis following decreased level of osteocalcin. We hypothesize that active inflammation following Mycobacterium avium subsp. paratuberculosis (MAP) infection results in elevation of undercarboxylated osteocalcin (ucOC) and downregulation of active osteocalcin in CD patients and cow-disease model (Johne’s disease). In this study, we measured ucOC, active osteocalcin, and calcium levels in sera from 42 cattle (21 infected with MAP and 21 healthy cattle), 18 CD patients, and 20 controls. The level of ucOC in MAP+ bovine samples was higher than that in MAP− controls (318 ± 57.2 nmol/mL vs. 289 ± 95.8 nmol/mL, P > 0.05). Consequently, mean calcium level in bovine MAP+ was significantly higher than that in bovine-MAP− samples (9.98 ± 0.998 mg/dL vs. 7.65 ± 2.12 mg/dL, P < 0.05). Also, the level of ucOC was higher in CD-MAP+ than in CD-MAP− (561 ± 23.7 nmol/mL vs. 285 ± 19.6 nmol/mL, P < 0.05). Interestingly, the mean osteocalcin level in MAP+ bovine was lower than that in MAP− bovine (797 ± 162 pg/mL vs. 1190 ± 43 pg/mL) and it was lower in CD-MAP+ than in CD-MAP− infection (1.89 ± 0.184 ng/mL vs. 2.19 ± 0.763 ng/mL) (P < 0.05). The correlation between MAP infection and elevation of sera ucOC, reduction of active osteocalcin and increased calcium supports MAP infection role in CD and complications with osteoporosis.
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Lu, Shan. "Decision-Making Application of the Cloud-Fog Hybrid Model Based on the Improved Convolutional Neural Network in Financial Services in Smart Medical Care". Computational Intelligence and Neuroscience 2022 (9.08.2022): 1–8. http://dx.doi.org/10.1155/2022/5732379.
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In order to alleviate the “difficulty in seeing a doctor” for the masses, continuously optimize the service process, and explore new financial service processes for admission and discharge, this study proposes a cloud-fog hybrid model UCNN-BN based on an improved convolutional neural network and applies it to financial services in smart medical care. Decision-making applications: this research improves and designs the UCNN network based on AlexNet and introduces small convolution layers to form convolution groups, making the network more adjustable. The network structure is simpler and more flexible, and it is easy to adjust the algorithm. The number of parameters is small, and it can be directly superimposed without having to add new network hidden layers. The experimental results show that the recognition rate of the UCNN network on the FER2013 and CK+ datasets is higher than that of other recognition methods, and the recognition rates on the FER2013 and CK+ datasets are 98% and 68.01%, due to other methods. This shows that the improved convolutional neural network used in this study for financial services in smart medical care has certain applicability, and small convolution kernels help to extract more subtle features, so as to identify more accurately.
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Toki, Hiroshi, Teruaki Myo i Kiyomi Ikeda. "TENSOR OPTIMIZED SHELL MODEL AND HYPERNUCLEI". International Journal of Modern Physics E 19, nr 12 (grudzień 2010): 2531–37. http://dx.doi.org/10.1142/s0218301310017046.
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The pion plays an important role for the structure of nucleus and nuclear matter. We propose a new theoretical framework, named the tensor optimized shell model (TOSM) to calculate the tensor interaction together with the unitary correlation operator method (UCOM) for the short range repulsion. We are able to handle the pion exchange interaction directly in the proposed framework. We compare the calculated results for 4 He with the rigorous calculation to show the power of TOSM to treat the tensor interaction. We then discuss the important role of pion in hypernuclei due to excitation of Σ baryon from Λ state.
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Martinez-Portilla, Raigam J., Jose R. Villafan-Bernal, Diana L. Lip-Sosa, Eva Meler, Jordi Clotet, Francisco J. Serna-Vela, Sergio Velazquez-Garcia, Leopoldo C. Serrano-Diaz i Francesc Figueras. "Osteocalcin Serum Levels in Gestational Diabetes Mellitus and Their Intrinsic and Extrinsic Determinants: Systematic Review and Meta-Analysis". Journal of Diabetes Research 2018 (30.12.2018): 1–15. http://dx.doi.org/10.1155/2018/4986735.
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Background. Undercarboxylated osteocalcin (ucOC) increases insulin release and insulin resistance in mice. In humans, evidence is scarce but a correlation of ucOC and total osteocalcin (tOC) with glycemic status markers has been demonstrated. The relationship of ucOC and tOC with gestational diabetes mellitus (GDM) has been even less characterized. Objective. To assess the mean difference of tOC and ucOC serum concentrations among nondiabetic pregnant women and women diagnosed as GDM in the second trimester of pregnancy and to determine the possible intrinsic and extrinsic contributors to this difference. Methods. A systematic search was performed to identify relevant studies published in English and Spanish using PubMed, SCOPUS, ISI Web of Knowledge, and PROSPERO database for meta-analysis. Observational studies measuring mean serum levels of osteocalcin among GDM, with at least 10 subjects analyzed in each group were selected. Mean difference (MD) by random effects model was used. Heterogeneity between studies was assessed using Cochran’s Q, H, and I2 statistics. Results. From 38 selected studies, 5 were retained for analysis for a total of 1119 pregnant women. Serum concentrations of tOC were not significantly different among women with GDM and nondiabetic pregnant controls (MD: 1.56; 95% CI: −0.70 to 3.82; p=0.175). Meanwhile, ucOC serum levels were significantly higher among women with GDM (MD: 1.17; 95% CI: 0.24 to 2.11; p=0.013). The only factor influencing tOC was the UV index, showing a reduction in mean difference between GDM and controls when exposed to higher concentrations of UV rays. Conclusions. This meta-analysis provides evidence to support the use of ucOC as a potential marker for GDM rather than tOC, yielding very little variability among studies and no difference among methods or brands used for its analysis.
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Rivier, Catherine L. "Urocortin 1 Inhibits Rat Leydig Cell Function". Endocrinology 149, nr 12 (21.08.2008): 6425–32. http://dx.doi.org/10.1210/en.2008-0417.
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Corticotropin-releasing factor (CRF) has previously been reported in rat testes in which it inhibits Leydig cells activity. However, recent studies in our laboratory have suggested that some of the effects originally attributed to CRF were instead due to the related peptide Urocortin 1 (Ucn 1) and that this latter hormone, not CRF, was detectable in Leydig cells. We show here that Ucn 1 [a mixed CRF receptor (CRFR) type 1 and CRFR2 agonist] and the CRFR1-selective peptide Stressin 1, but not Ucn 2 or Ucn 3 (both considered selective CRFR2 ligands), significantly blunt the testosterone response to human chorionic gonadotropin. The effect of Ucn 1 is observed regardless of whether this peptide is injected iv or directly into the testes, and it is reversed by the mixed CRFR1/R2 antagonist Astressin B. Blockade of GnRH receptors with the antagonist Azalin B does not interfere with the influence of Ucn 1, thereby demonstrating that pituitary luteinizing hormone does not appear to be involved in this model. Collectively these results suggest that Ucn 1, not CRF, is present in the rat testes and interferes with Leydig cell activity. However, whereas we previously reported that alcohol up-regulated gonadal Ucn 1 gene expression, CRF receptor antagonists were unable to reverse the inhibitory effect exerted by alcohol on human chorionic gonadotropin-induced testosterone release. The functional role played by testicular Ucn 1 in stress models characterized by blunted androgen levels therefore needs to be further investigated.
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Gallani, Maria Cecília Bueno Jayme, Roberta Cunha Rodrigues Colombo, Eliane de Araújo Cintra i Sandra Bruneni Rigacci. "Coleta de dados: a avaliação de um modelo piloto". Revista Latino-Americana de Enfermagem 4, nr 2 (lipiec 1996): 179–99. http://dx.doi.org/10.1590/s0104-11691996000200012.
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Após o desenvolvimento e implementação de um modelo piloto do instrumento de coleta de dados (ICDP) para Unidade Coronária (UCO), tivemos como objetivos avaliar as considerações dos enfermeiros sobre a aplicabilidade deste instrumento e de sua adequação na UCO do HC-UNICAMP bem como levantar subsídios para contribuir na sua reelaboração. A avaliação, realizada através de um questionário entregue a onze enfermeiros que participaram da implementação do ICDP, mostrou-nos que os enfermeiros consideraram válidos o desenvolvimento e implementação do ICDP, interpretado como adequado em forma e conteúdo para pacientes cardiopatas, além de fornecer subsídios para a elaboração do instrumento definitivo de ICD.
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Díaz-López, Andrés, Mònica Bulló, Marti Juanola-Falgarona, Miguel A. Martínez-González, Ramón Estruch, Maria-Isabel Covas, Fernando Arós i Jordi Salas-Salvadó. "Reduced Serum Concentrations of Carboxylated and Undercarboxylated Osteocalcin Are Associated With Risk of Developing Type 2 Diabetes Mellitus in a High Cardiovascular Risk Population: A Nested Case-Control Study". Journal of Clinical Endocrinology & Metabolism 98, nr 11 (1.11.2013): 4524–31. http://dx.doi.org/10.1210/jc.2013-2472.
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Context and Objective: Because it has been suggested that osteocalcin (OC), an osteoblast-derived hormone, is a new link between bone and glucose metabolism, we tested whether serum carboxylated osteocalcin (cOC) and undercarboxylated osteocalcin (ucOC) levels are independently associated with the development of type 2 diabetes in subjects at high cardiovascular risk. Design, Setting, and Participants: A prospective, nested case-control study was conducted using data from the Prevención con Dieta Mediterránea (PREDIMED) study. We included 153 case subjects with newly diagnosed diabetes and 306 individually matched control subjects free of diabetes identified during a mean 5-year follow-up. Conditional logistic regression models were used to estimate matched odds ratios for incident diabetes according to categories of both forms of OC measured by ELISAs. Results: Baseline serum concentrations of both forms of OC were significantly lower in case subjects than in control subjects. In subjects with incident cases of diabetes, concentrations of cOC, but not of ucOC, were inversely and significantly associated with homeostasis model assessment of insulin resistance levels (β = −0.335) and with fasting glucose concentrations (β = −0.044) in control subjects, independent of other relevant confounders. In the conditional logistic model that took into account the matching factors, the odds ratios for diabetes incidence in the lowest vs the highest tertile of cOC and ucOC were 2.03 (95% confidence interval, 1.32–3.13) and 1.88 (1.23–2.85), respectively. Further adjustment for family history of diabetes, lifestyle, and other confounding factors did not appreciably change the magnitude of these associations. Conclusion: In a population at high cardiovascular risk, low concentrations of serum cOC and ucOC were strongly associated with an increased risk of incident diabetes.
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Sidhu, Steve, Wolfgang Schreyer, Sean Vanbergen, Shinsuke Kawasaki, Ryohei Matsumiya, Takahiro Okamura i Ruediger Picker. "Estimated performance of the TRIUMF ultracold neutron source and electric dipole moment apparatus". EPJ Web of Conferences 282 (2023): 01015. http://dx.doi.org/10.1051/epjconf/202328201015.
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Searches for the permanent electric dipole moment of the neutron (nEDM) provide strong constraints on theories beyond the Standard Model of particle physics. The TUCAN collaboration is constructing a source for ultra-cold neutrons (UCN) and an apparatus to search for the nEDM at TRIUMF, Vancouver, Canada. In this work, we estimate that the spallation-driven UCN source based on a superfluid helium converter will provide (1.38 ± 0.02) 107 polarized UCN at a density of 217 ± 3 UCN/cm3 to a room-temperature EDM experiment per fill. With (1.43 ± 0.02) 106 neutrons detected after the Ramsey cycle, the statistical sensitivity for an nEDM search per storage cycle will be (1.94 ± 0.06) × 10−25 ecm (1σ). The goal sensitivity of 10−27 ecm (1σ) can be reached within 281 ± 16 measurement days.
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Espinoza-Monje, Marcela, Jorge Campos, Eduardo Alvarez Villamil, Alonso Jerez, Stefania Dentice Maidana, Mariano Elean, Susana Salva, Haruki Kitazawa, Julio Villena i Apolinaria García-Cancino. "Characterization of Weissella viridescens UCO-SMC3 as a Potential Probiotic for the Skin: Its Beneficial Role in the Pathogenesis of Acne Vulgaris". Microorganisms 9, nr 7 (13.07.2021): 1486. http://dx.doi.org/10.3390/microorganisms9071486.
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Previously, we isolated lactic acid bacteria from the slime of the garden snail Helix aspersa Müller and selected Weissella viridescens UCO-SMC3 because of its ability to inhibit in vitro the growth of the skin-associated pathogen Cutibacterium acnes. The present study aimed to characterize the antimicrobial and immunomodulatory properties of W. viridescens UCO-SMC3 and to demonstrate its beneficial effect in the treatment of acne vulgaris. Our in vitro studies showed that the UCO-SMC3 strain resists adverse gastrointestinal conditions, inhibits the growth of clinical isolates of C. acnes, and reduces the adhesion of the pathogen to keratinocytes. Furthermore, in vivo studies in a mice model of C. acnes infection demonstrated that W. viridescens UCO-SMC3 beneficially modulates the immune response against the skin pathogen. Both the oral and topical administration of the UCO-SCM3 strain was capable of reducing the replication of C. acnes in skin lesions and beneficially modulating the inflammatory response. Of note, orally administered W. viridescens UCO-SMC3 induced more remarkable changes in the immune response to C. acnes than the topical treatment. However, the topical administration of W. viridescens UCO-SMC3 was more efficient than the oral treatment to reduce pathogen bacterial loads in the skin, and effects probably related to its ability to inhibit and antagonize the adhesion of C. acnes. Furthermore, a pilot study in acne volunteers demonstrated the capacity of a facial cream containing the UCO-SMC3 strain to reduce acne lesions. The results presented here encourage further mechanistic and clinical investigations to characterize W. viridescens UCO-SMC3 as a probiotic for acne vulgaris treatment.
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NESVIZHEVSKY, V. V., G. PIGNOL i K. V. PROTASOV. "NANOPARTICLES AS A POSSIBLE MODERATOR FOR AN ULTRACOLD NEUTRON SOURCE". International Journal of Nanoscience 06, nr 06 (grudzień 2007): 485–99. http://dx.doi.org/10.1142/s0219581x07005073.
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Ultracold and very cold neutrons (UCN and VCN) interact strongly with nanoparticles due to the similarity of their wavelengths and nanoparticles sizes. We analyze the hypothesis that this interaction can provide efficient cooling of neutrons by ultracold nanoparticles at certain experimental conditions, thus increasing the density of UCN by many orders of magnitude. The present analytical and numerical description of the problem is limited to the model of independent nanoparticles at zero temperature. Constraints of application of this model are discussed.
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MYO, TAKAYUKI, HIROSHI TOKI, SATORU SUGIMOTO, KIYOSHI KATŌ, YUMA KIKUCHI i KIYOMI IKEDA. "A SYSTEMATIC STUDY OF THE TENSOR CORRELATION IN He AND Li ISOTOPES". Modern Physics Letters A 23, nr 27n30 (30.09.2008): 2577–80. http://dx.doi.org/10.1142/s0217732308029836.
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We investigate the tensor correlations in He and Li isotopes systematically. We propose the tensor-optimized shell model (TOSM) to describe the strong tensor correlation arising from the bare nuclear force in nuclei. Using TOSM for Li isotopes, we investigate the anomalous structures of 9,10,11 Li based on the 9 Li +n+n model where the 9 Li cluster is described by TOSM. As a result, the couplings between the tensor correlation in 9 Li and the extra two neutrons emerge Pauli-blocking, which naturally increases the s2 component to develop the halo structure in 11 Li . We further describe the short-range correlation arising from the repulsive core in the bare nuclear force by the unitary correlation operator method (UCOM). We propose the new framework of TOSM+UCOM for the nuclear structure study starting from the bare nuclear force.
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Ahmed, Mariyam Shabeena, Siti Aqlima Ahmad, Mohd Yunus Shukor i Mohd Termizi Yusof. "Statistical Optimisation of Used-Cooking-Oil Degradation by Burkholderia vietnamiensis AQ5-12 and Burkholderia sp. AQ5-13". Processes 10, nr 11 (24.10.2022): 2178. http://dx.doi.org/10.3390/pr10112178.
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Used cooking oil (UCO) is a hydrocarbon that causes significant environmental pollution globally. Oil is a difficult pollutant to remove from the environment due to its hydrophobic nature. Bioremediation is preferred over chemical and physical remediation approaches as it is more economical and environmentally friendly. Hence, the search for a microbe with outstanding degrading capability is imperative due to the nature of hydrocarbons as pollutants. The current study evaluates the ability of glyphosate degrader isolates, Burkholderia vietnamiensis AQ5-12 and Burkholderia sp. AQ5-13, to degrade UCO as the sole carbon source. The physico-cultural conditions affecting the activities of the isolates were studied using one-factor-at-a-time (OFAT) and response-surface methodology (RSM). The temperature, agitation speed, UCO concentration, nitrogen supply, yeast extract concentration, and inoculum size were optimised during a 7-day incubation period. Based on the OFAT results, the highest degradations were 62.23% and 58.33% for the isolates AQ5-12 and AQ5-13, respectively. The optimisation of RSM showed 83.42% and 87.09% degradation of the UCO by the AQ5-12 and AQ5-13 isolates. Parameters including the temperature, yeast extract, and ammonium sulphate concentration provided significant interaction for the RSM model in the isolate AQ5-12. Meanwhile, AQ5-13 showed significance in all five parameters: pH, UCO concentration, temperature, yeast extract, and ammonium sulphate concentration. The degradation efficiency validated via RSM demonstrated better results than the OFAT approach. The model validation has verified no significant difference between the experimental and predicted values. The ability of these two bacterial isolates to degrade UCO is a worthwhile procedure in the bioremediation of hydrocarbon-rich areas.
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TOKI, HIROSHI, TAKAYUKI MYO i KIYOMI IKEDA. "TENSOR OPTIMIZED SHELL MODEL AND THE ROLE OF PION IN FINITE NUCLEI". International Journal of Modern Physics E 18, nr 10 (listopad 2009): 2040–44. http://dx.doi.org/10.1142/s0218301309014251.
Pełny tekst źródłaStreszczenie:
The pion plays an important role for the structure of nucleus and nuclear matter. We propose a new theoretical framework, named the tensor optimized shell model (TOSM) to calculate the tensor interaction together with the unitary correlation operator method (UCOM) for the short range repulsion. We are able to handle the pion exchange interaction directly in the proposed framework. We compare the calculated results for 4 He with the rigorous calculation to show the power of TOSM to treat the tensor interaction.
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Jones, Rebecca C., Kevin M. Lawrence, Scott M. Higgins, Stephen M. Richardson i Paul A. Townsend. "Urocortin-1 Is Chondroprotective in Response to Acute Cartilage Injury via Modulation of Piezo1". International Journal of Molecular Sciences 23, nr 9 (4.05.2022): 5119. http://dx.doi.org/10.3390/ijms23095119.
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Post-traumatic OA (PTOA) is often triggered by injurious, high-impact loading events which result in rapid, excessive chondrocyte cell death and a phenotypic shift in residual cells toward a more catabolic state. As such, the identification of a disease-modifying OA drug (DMOAD) that can protect chondrocytes from death following impact injury, and thereby prevent cartilage degradation and progression to PTOA, would offer a novel intervention. We have previously shown that urocortin-1 (Ucn) is an essential endogenous pro-survival factor that protects chondrocytes from OA-associated pro-apoptotic stimuli. Here, using a drop tower PTOA-induction model, we demonstrate the extent of Ucn’s chondroprotective role in cartilage explants exposed to excessive impact load. Using pathway-specific agonists and antagonists, we show that Ucn acts to block load-induced intracellular calcium accumulation through blockade of the non-selective cation channel Piezo1 rather than TRPV4. This protective effect is mediated primarily through the Ucn receptor CRF-R1 rather than CRF-R2. Crucially, we demonstrate that the chondroprotective effect of Ucn is maintained whether it is applied pre-impact or post-impact, highlighting the potential of Ucn as a novel DMOAD for the prevention of injurious impact overload-induced PTOA.
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Vanbergen, Sean, Wolfgang Schreyer, Shomi Ahmed, Taraneh Andalib, Mike Barnes, Beryl Bell, Jason Chak i in. "A spallation target at TRIUMF for fundamental neutron physics". EPJ Web of Conferences 285 (2023): 07004. http://dx.doi.org/10.1051/epjconf/202328507004.
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Ultracold neutrons (UCNs) are a powerful tool for probing the Standard Model at high precision. The TRIUMF Ultracold Advanced Neutron (TUCAN) collaboration is building a new UCN source to provide unprecedented densities of UCNs for experiments. This source will use a tantalum-clad tungsten spallation target, receiving up to 40 µA of 480-MeV protons from TRIUMF’s main cyclotron. The beamline and target were constructed from 2014 to 2016 and operated at beam currents up to 10 µA from 2017 to 2019 as part of a prototype UCN source. We describe the design choices for the target and target-handling system, as well as our benchmarking of the target performance using UCN production measurements.
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Merino, J. S., A. García, E. Pastene, A. Salas, K. Saez i C. L. González. "Lactobacillus fermentum UCO-979C strongly inhibited Helicobacter pylori SS1 in Meriones unguiculatus". Beneficial Microbes 9, nr 4 (15.06.2018): 625–27. http://dx.doi.org/10.3920/bm2017.0160.
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Searching for bacterial probiotics active upon Helicobacter pylori continue to be an important clinical challenge because of the increased prevalence of this highly priority pathogen in humans. In this work, we assess the in vivo anti-H. pylori SS1 (cagA+/vacAs2m2+) properties of a previously isolated human gastric probiotic strain Lactobacillus fermentum UCO-979C by using a Meriones unguiculatus (Mongolian gerbil) model. Animals were administered with a saline suspension of L. fermentum UCO-979C or H. pylori SS1 as negative and positive control for H. pylori colonisation controls, prior to assayed the challenge group that was administered with these two species per animal for detecting protective activity of the probiotic strain against colonisation. The results showed that L. fermentum UCO-979C strongly inhibited the colonisation of H. pylori decreasing up to 87% of the colonisation in the antrum by the pathogen, suggesting that this probiotic strain has a strong probiotic activity against H. pylori in the most valuable animal model for in vivo assays nowadays.
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Liu, Yihui, Xiaoying Liu, Joshua R Lewis, Kaye Brock, Tara C Brennan-Speranza i Armando Teixeira-Pinto. "Relationship between serum osteocalcin/undercarboxylated osteocalcin and type 2 diabetes: a systematic review/meta-analysis study protocol". BMJ Open 9, nr 3 (marzec 2019): e023918. http://dx.doi.org/10.1136/bmjopen-2018-023918.
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IntroductionThe global burden of type 2 diabetes (T2DM) is steadily increasing. Experimental studies have demonstrated that a novel hormone secreted by bone cells, osteocalcin (OC), can stimulate beta-cell proliferation and improve insulin sensitivity in mice. Observational studies in humans have investigated the relationship between OC and metabolic parameters, and T2DM. Importantly, few studies have reported on the undercarboxylated form of OC (ucOC), which is the putative active form of OC suggested to affect glucose metabolism.ObjectivesWe will conduct a systematic review and meta-analysis to: (1) compare the levels of serum OC and ucOC between T2DM and normal glucose-tolerant controls (NGC); (2) investigate the risk ratios between serum OC and ucOC, and T2DM; (3) determine the correlation coefficient between OC and ucOC and fasting insulin levels, homeostatic model assessment-insulin resistance, haemoglobin A1c and fasting glucose levels and (4) explore potential sources of between-study heterogeneity. The secondary objective is to compare the serum OC and ucOC between pre-diabetes (PD) and NGC and between T2DM and PD.hods and analysisThis study will report items in line with the guidelines outlined in preferred reporting items for systematic reviews and meta-analysis of observational studies in epidemiology. We will include observational studies (cohort, case-control and cross-sectional studies) and intervention studies with baseline data. Three databases (MEDLINE, EMBASE and SCOPUS) will be searched from inception until July 2018 without language restrictions. Two reviewers will independently screen the titles and abstracts and conduct a full-text assessment to identify eligible studies. Discrepancies will be resolved by consensus with a third reviewer. The risk of bias assessment will be conducted by two reviewers independently based on the Newcastle-Ottawa Scale. Potential sources of between-study heterogeneity will be tested using meta-regression/subgroup analyses. Contour-enhanced funnel plots and Egger’s test will be used to identify potential publication bias.Ethics and disseminationFormal ethical approval is not required. We will disseminate the results to a peer-reviewed publication and conference presentation.PROSPERO registration numberCRD42017073127.
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Liu, Chun-Na, Cui Yang, Xin-Yu Liu i Shengnan Li. "In vivo protective effects of urocortin on ischemia-reperfusion injury in rat heart via free radical mechanisms". Canadian Journal of Physiology and Pharmacology 83, nr 6 (1.06.2005): 459–65. http://dx.doi.org/10.1139/y05-033.
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The aim of this study was to investigate the effects of urocortin (UCN) on oxidative stress and the mechanisms of urocortin on ischemia–reperfusion injury in vivo in the rat model. Thirty-six Sprague–Dawley rats were divided into 6 groups, including sham, control (normal saline solution), UCN1, UCN2, UCN3, and verapamil groups. The left anterior descending coronary artery of all rats except those in the sham group was treated with a 30-min occlusion followed by a 60-min reperfusion. Just before the occlusion, normal saline solution, UCN (5, 10, and 20 µg/kg body mass), or verapamil (1 mg/kg body mass) was administered. Heart rates, beating rhythm, and S-T segments were constantly monitored using an ECG. At the completion of the drug adminstration, blood samples were taken to measure the activity of superoxide dismutase (SOD), malonaldehyde (MDA), glutathione peroxidase (GSH-PX), and nitric oxide (NO) to evaluate the effects of UCN on oxidative stress. Finally, the size of infarction was measured. Arrhythmia rates were significantly lower, and the infarction size was significantly smaller (p < 0.01), in the UCN groups vs. the control group. Verapamil also significantly reduced arrhythmia rates and infarction size. The MDA activities were remarkably diminished, whereas the SOD, GSH-PX, and NO activities were significantly higher in the UCN and VER groups (p < 0.01). MDA, SOD, and NO activities were strongly correlated with UCN doses. These results suggest that UCN may play a protective role in ischemia–reperfusion injury in rat hearts against the oxidative stress by inhibiting free radicals' activities. Key words: urocortin, ischemia–reperfusion injury, arrhythmias, free radical anti-oxidative enzymes, oxidative stress.
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Wu, S. Vincent, Pu-Qing Yuan, Jim Lai, Kelvin Wong, Monica C. Chen, Gordon V. Ohning i Yvette Taché. "Activation of Type 1 CRH Receptor Isoforms Induces Serotonin Release from Human Carcinoid BON-1N Cells: An Enterochromaffin Cell Model". Endocrinology 152, nr 1 (1.01.2011): 126–37. http://dx.doi.org/10.1210/en.2010-0997.
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Abstract CRH and 5-hydroxytryptamine (5-HT) are expressed in human colonic enterochromaffin (EC) cells, but their interactions at the cellular level remain largely unknown. The mechanistic and functional relationship between CRH and 5-HT systems in EC cells was investigated in a human carcinoid cloned BON cell line (BON-1N), widely used as an in vitro model of EC cell function. First, we identified multiple CRH1 splice variants, including CRH1a, CRH1c, CRH1f, and a novel form lacking exon 4, designated here as CRH1i, in the BON-1N cells. The expression of CRH1i was also confirmed in human brain cortex, pituitary gland, and ileum. Immunocytochemistry and immunoblot analysis confirmed that BON-1N cells were CRH1 and 5-HT positive. CRH, urocortin (Ucn)-1, and cortagine, a selective CRH1 agonist, all increased intracellular cAMP, and this concentration-dependent response was inhibited by CRH1-selective antagonist NBI-35965. CRH and Ucn-1, but not Ucn-2, stimulated significant ERK1/2 phosphorylation. In transfected human embryonic kidney-293 cells, CRH1i isoforms produced a significant increase in pERK1/2 in response to CRH1 agonists that was sensitive to NBI-35965. CRH and Ucn-1 stimulated 5-HT release that reached a maximal increase of 3.3- and 4-fold at 10−8m over the basal level, respectively. In addition, exposure to CRH for 24-h up-regulated tryptophan hydroxylase-1 mRNA levels in the BON-1N cells. These findings define the expression of EC cell-specific CRH1 isoforms and activation of CRH1-dependent pathways leading to 5-HT release and synthesis; thus, providing functional evidence of a link exists between CRH and 5-HT systems, which have implications in stress-induced CRH1 and 5-HT-mediated stimulation of lower intestinal function.
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Bravo Cruz, Néstor Eugenio, Juan Ignacio Oviedo Pino i Ciro Alirio Figueroa López. "Identificación, medición y valoración del capital humano a partir del modelo Skandia: aplicación en una UCIN". Contaduría Universidad de Antioquia, nr 82 (7.02.2023): 27–47. http://dx.doi.org/10.17533/udea.rc.n82a02.
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El presente artículo da cuenta de la importancia del capital humano en la gestión organizacional y en este marco lo identifica, mide y valora a partir de la aplicación del modelo Skandia en una unidad de cuidado intensivo neonatal—UCIN—. El análisis se desarrolla bajo una metodología de enfoque mixto y de profundidad aplicada. Se realizó un análisis descriptivo para reconocer la importancia de los intangibles y, de esta manera, identificar las principales características de modelo Skandia aplicables en la valoración del capital humano. Siguiendo los enfoques del modelo, se revisaron diferentes diseños metodológicos de publicaciones previas y se ajustaron para construir los índices. Se concluye en que la adaptabilidad del navegador facilita su aplicación en todo tipo de organizaciones y contribuye a los procesos de gestión integral con resultados visibles a mediano y largo plazo, los cuales le permiten a la administración monitorear y emprender oportunamente acciones cuando se requiera. Para el caso de la UCIN, la aplicación del navegador del modelo Skandia permitió detectar oportunidades de mejora relacionados con el reconocimiento del personal y las modalidades de contratación.
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Illa, Míriam, Laura Pla, Sergio Berdún, Mònica Mir, Lourdes Rivas, Samuel Dulay, Nicole Picard-Hagen, Josep Samitier, Eduard Gratacós i Elisenda Eixarch. "Miniaturized Electrochemical Sensors to Monitor Fetal Hypoxia and Acidosis in a Pregnant Sheep Model". Biomedicines 9, nr 10 (28.09.2021): 1344. http://dx.doi.org/10.3390/biomedicines9101344.
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Perinatal asphyxia is a major cause of severe brain damage and death. For its prenatal identification, Doppler ultrasound has been used as a surrogate marker of fetal hypoxia. However, Doppler evaluation cannot be performed continuously. We have evaluated the performance of a miniaturized multiparametric sensor aiming to evaluate tissular oxygen and pH changes continuously in an umbilical cord occlusion (UCO) sheep model. The electrochemical sensors were inserted in fetal hindlimb skeletal muscle and electrochemical signals were recorded. Fetal hemodynamic changes and metabolic status were also monitored during the experiment. Additionally, histological assessment of the tissue surrounding the sensors was performed. Both electrochemical sensors detected the pO2 and pH changes induced by the UCO and these changes were correlated with hemodynamic parameters as well as with pH and oxygen content in the blood. Finally, histological assessment revealed no signs of alteration on the same day of insertion. This study provides the first evidence showing the application of miniaturized multiparametric electrochemical sensors detecting changes in oxygen and pH in skeletal muscular tissue in a fetal sheep model.
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HU, J., H. TOKI, W. WEN i H. SHEN. "RELATIVISTIC HARTREE-FOCK MODEL WITH SHORT RANGE CORRELATION IN NUCLEAR MATTER". Modern Physics Letters A 25, nr 21n23 (30.07.2010): 2008–9. http://dx.doi.org/10.1142/s0217732310000885.
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We introduce the form factor and short range correlation in the relativistic Hartree-Fock approximation (RHFU) to study the properties of nuclear matter. We treat the short range correlation with the unitary correlation operator method (UCOM). In this framework, we can perfectly reproduce the equation of state of pure neutron matter obtained by the relativistic Brueckner-Hartree-Fock theory with the Bonn potential. We apply the RHFU model to symmetric nuclear matter. The contribution of ρ meson is cut down largely by the form factor of the size in the realistic nucleon-nucleon interaction. The short range correlation has a significant effect on the Fock energies of pion and ρ meson exchange interaction.
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Nelson, Everette J. R., Laura M. Tuschong i Dennis D. Hickstein. "Lentiviral Vectors Incorporating Ubiquitous Chromatin Opening Element Driving Canine CD18 Expression". Blood 128, nr 22 (2.12.2016): 5890. http://dx.doi.org/10.1182/blood.v128.22.5890.5890.
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Abstract Leukocyte adhesion deficiency type 1 (LAD1) in humans is caused due to mutations in the ITGB2 gene encoding the leukocyte CD18 subunit (b2 integrin). This results in defective leukocyte adhesion and migration leading to recurrent episodes of life-threatening bacterial infection. Canine leukocyte adhesion deficiency (CLAD) represents a disease-specific large animal model of LAD1 in which new therapeutic approaches could be tested. Our previous studies have demonstrated variable efficiency of CD18 expression under the control of several promoters. These include cellular promoters such as those of human elongation factor 1a (hEF1a): long (1169bp) and short (248bp) fragments, human phosphoglycerate kinase (hPGK), human CD11b and human CD18 genes. In addition, murine stem cell virus (MSCV) promoter has also been demonstrated to lead to very high levels of CD18 expression in CLAD CD34+ cells thereby reversing the CLAD phenotype in dogs previously treated with both foamy and lentiviral vectors. But, due to potential genotoxicity associated with the use of viral promoters, we continued our efforts in search of novel cellular promoters. One such promoter is the ubiquitous chromatin opening element (UCOE) from the human heterogeneous ribonucleoprotein A2/B1 and chromobox homolog 3 (HNRPA2B1-CBX3) loci. UCOE has been previously shown to display reproducible and stable transgene expression within the context of a self-inactivating (SIN) lentiviral vector in the absence of classical enhancer activity (Zhang et al., Blood 2007).It has also been shown to confer resistance to DNA methylation-mediated transgene silencing even upon integration into the heterochromatin regions of the host chromosome (Zhang et al., Mol Ther. 2010). Since the full-length element is about 2.6 kb, we cloned and tested different fragment lengths of the UCOE promoter in a SIN lentiviral vector (pCL20) in CLAD CD34+ cells in vitro. Efficiency of expression of CD18 obtained with the six promoter fragments of UCOE (in bp), namely U3'631, U3'1262, U3'652, U5'1357, U5'723 and U5'655 were compared to those obtained with an MSCV promoter. Functional viral titers were first determined using a human LAD EBV-transformed B-cell line that lacks endogenous human CD18. When comparable titers of each vector were used in an overnight transduction of CLAD CD34+ cells after a 24h cytokine prestimulation in vitro, the percentage of CD18+ cells 5 days after transduction were as follows: U3'631 - 8.49%, U3'1262 - 15.9%, U3'652 - 21.3% (tested at MOI 100), U5'1357 - 2.05% (tested at MOI 30), U5'723 - 2.44% (tested at MOI 20), U5'655 - 3.01% (tested at MOI 50) and MSCV - 35.3% (tested at MOI 100). The CD18 expression levels driven by some of these promoter fragments were comparable to those driven by cellular promoters mentioned previously. The UCOE is promising in that it could overcome possible gene silencing effects when used in vivo, unlike promoters such as EF1a and PGK which were largely subjected to post-transcriptional gene silencing with sub-therapeutic levels of CD18 as previously tested in the dog model. Hence, functional correction of the CD18 defect could be achieved with candidate UCOE-incorporating SIN lentiviral vector(s) when used in the treatment of CLAD dogs. Disclosures No relevant conflicts of interest to declare.