Artykuły w czasopismach: „Tripped Line”

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Bhui, Pratyasa, i Nilanjan Senroy. "Online Identification of Tripped Line for Transient Stability Assessment". IEEE Transactions on Power Systems 31, nr 3 (maj 2016): 2214–24. http://dx.doi.org/10.1109/tpwrs.2015.2440562.

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Tao, Hao, Yao H¨ua Tang, Xu Zhan Zhou i Hong Wei Wang. "Frequency Response Model of Regional Power Grid Based on Parameter Identification on Trip Process of Transmission Line". Applied Mechanics and Materials 448-453 (październik 2013): 2406–10. http://dx.doi.org/10.4028/www.scientific.net/amm.448-453.2406.

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Many large power grid accidents show that the tripped transmission line has great impact on system stability. The primary frequency regulation effects of generation units play key roles during a trip procedure. In this paper, a frequency stability dynamic mathematic model of regional power grid was built based on records of a practical trip accident of transmission line between regional grids. Key parameters of the model were identified. The identified parameters are within their reasonable regions. The simulation results show that the modeling method based on parameter identification can be used for modeling of transmission line trip accident procedure and relative frequency stability analyses on power grids.

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Jena, Manas Kumar, Bijaya Ketan Panigrahi i Subhransu Ranjan Samantaray. "Online detection of tripped transmission line to improve wide-area SA in power transmission system". IET Generation, Transmission & Distribution 12, nr 2 (30.01.2018): 288–94. http://dx.doi.org/10.1049/iet-gtd.2016.1964.

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L. Prikler, G. Bán, M. Kizilcay, G. Tari, A. Tombor i J. Zerenyi. "Influence of the Secondary Arc on the Operation of Single Phase Autoreclosure of the 400 kV interconnection between Hungary and Croatia". Journal of Energy - Energija 59, nr 1-4 (22.08.2022): 61–69. http://dx.doi.org/10.37798/2010591-4279.

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Sažetak: Faults on EHV lines are generally single-phase-to-ground ones and not permanent in the majority of cases. Thus single phase auto reclosure (SPAR), at which the faulty phases are tripped for a short time, eliminates the predominant part of the faults [1,2]. The secondary arc, which follows the high power arc after tripping the faulty phases at both side of the line may endanger the successfulness of reclosing if the duration of the switched off interval (dead time) is not long enough to ensure the extinction of the arc. The secondary arcing times recorded on different EHV lines or measured in laboratory tests show significant spread, consequently, to select a dead time according to the longest experimental secondary arc extinction time is not feasible. During commissioning of the double circuit 420 kV interconnection between Hungary and Croatia several staged faults were initiated to analyze the arc extinction performance. Initially the line was in operation by connecting the two circuits in parallel along the 1/3rd of the full length. In this configuration the longest secondary arc extinction time was 4 seconds and the secondary arc has not extinguished in 27s in one of the tests, so the line had to be tripped out to clear the staged fault. Later on, the length of the Croatian section of the line has been significantly shortened after putting a new substation into service. The increased performance of SPAR of the new arrangement has been proved with field tests. A realistic representation of the secondary arcs is essential in determining the auto-reclosure performance of EHV transmission lines. As shown in the paper, the random variation of the arc parameters influences significantly the arc extinction time. The results of the field tests confirmed the importance of the distributed nature of the transmission line and the nonlinear characteristic of the arc resistance in the intermittent region of arcing, where temporary extinctions and sudden re-ignitions in the arc channel produce transient wave processes along the line.

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B, Vivekanadam. "Analysis of Voltage Stability Index under Stressed Operating Conditions in Bus Power Systems". December 2020 2, nr 4 (9.02.2021): 146–50. http://dx.doi.org/10.36548/jeea.2020.4.001.

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In stressed operating conditions, several types of voltage stability indices (VSI) are used for the assessment of voltage stability at specific operating points. The performance of various available VSIs are compared in this paper. The one generation unit tripped effects, single line to ground (SLG) fault and inductive loading variations occur in combinational format with such operating conditions. Voltage collapse occurs in the lines or nodes due to the stressed operating conditions (SOC). SLG fault, loading effects, power margin, line continency ranking, and line number are some of the performance parameters of VSI analysed in this paper. For utilization of reactive power compensation, the proper location can be chosen with the help of critical line and node analysis (CLNA) that makes use of VSIs. For any SOC, accurate voltage instability prediction is performed using VSI as per the simulation results. Under voltage collapse due to multiple causes, the voltage stability assessment of any specific line can be performed using this information.

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Kushwaha, Pawan Kumar, i Chayan Bhattacharjee. "A Research on Selection of Appropriate Stability Index under Adverse System Conditions for the Assessment of Voltage Stability of an IEEE 14 Bus Power System". European Journal of Electrical Engineering 22, nr 6 (31.12.2020): 435–46. http://dx.doi.org/10.18280/ejee.220605.

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For voltage stability assessment at a given operating point, various types of voltage stability indices (VSIs) have been proposed in the literature. In this paper, the voltage stability assessment of an IEEE-14 bus system is done for performance comparison of different types of VSIs available, under certain critical and practical stressed operating conditions (SOCs). The performance comparison of various VSIs under the considered SOCs is not reported in the literature. Such SOCs include the combinational occurrence of – variation in inductive loading, single line to ground (SLG) fault and effect of one generation unit tripped. These SOCs are the prime cause of voltage collapse of any node/line. The results show the performance of various VSIs with respect to line number, contingency ranking of the line, power margin, effects of loading and SLG fault. These VSIs are also instrumental in critical line and node analysis (CLNA) which is useful in the choice of proper location for reactive power compensation required. The simulated results provide the best performing VSI for accurate prediction of voltage instability under any considered SOC. This information is essential for voltage stability assessment of a particular line under multiple causes of voltage collapse.

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Forcan, Miodrag, i Zoran Stojanović. "A standby protection scheme to complement transverse differential protection of double circuit lines in the case of one parallel line tripped". Electric Power Systems Research 201 (grudzień 2021): 107570. http://dx.doi.org/10.1016/j.epsr.2021.107570.

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Wijana, Wayan, I. Ketut Wijaya i I. Made Mataram. "ANALISIS KOORDINASI RELAY ARUS LEBIH (OCR) DAN RECLOSER PADA SISTEM EKSISTING PENYULANG BUKIT JATI". Jurnal SPEKTRUM 5, nr 2 (17.12.2018): 61. http://dx.doi.org/10.24843/spektrum.2018.v05.i02.p08.

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Protection systems play an important role to maintain the reliability of distribution line. Over current relay (OCR) is one of the equipments used as a protection line of 20 kV distribution. Feeder of Bukit Jati is equipped over current protection relay equipment installed in Recloser of Banda and relay in the substation feeder. Based on the data of PT. PLN (Persero) APD Bali, there are 5 time-short circuit disorders which one of them tripped the Bukit Jati feeder. Problems over current relay coordination failures can be overcome by analyzing the coordination of protection systems in the feeder of Bukit Jati. The analysis was done by recalculating the over current relay setting and create the coordination curve of the existing setting and compared it with the coordination curve setting according to the calculation result. The results of the calculation of instant recloser recycling settings obtained by 1.246 A with time multiple setting (Tms) of 0.11 while the value of the instant current setting of the feeder of 2.992 A with Tms of 0.38. Based on the simulation result using ETAP program, it is known that over current relay coordination has worked according to the protection zone when the noise occurrence behind the recloser bus did not result in a trip feeder.

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Agarwal, Shobha, C. K. Panigrahi, Aishwarya Sahoo i Sanitha Mishra. "A Novel Study on Bipolar High Voltage Direct Current Transmission Lines Protection Schemes". International Journal of Electrical and Computer Engineering (IJECE) 8, nr 4 (1.08.2018): 1977. http://dx.doi.org/10.11591/ijece.v8i4.pp1977-1984.

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In long dc transmission lines identification of fault is important for transferring a large amount of power. In bipolar Line commutated converter transmission lines are subjected to harsh weather condition so accurate and rapid clearance of fault is essential. A comparative study of the bipolar system with both converters healthy and one converter tripped is studied. Most of the research paper has focussed on transmission line faults in bipolar mode but none of them had focussed when HVDC system works in monopolar mode after the fault. In the proposed scheme the voltage signals are extracted from both poles of the rectifier ends and are processed to identify the faults in transmission lines.The Artificial neural network is utilised in detecting the fault in both bipolar and monopolar system. Since it can identify the relationship between input and output data to detect the fault pattern it can be utilised under all conditions. Moreover, benefits of the proposed method are its accuracy, no requirement of the communication system as it acquires data from one end and has a reach setting of 99%.

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Zhang, Jingru, Baina He, Xingmin He, Yanchen Dong i Renzhuo Jiang. "Research on fault clearing scheme for half-bridge modular multilevel converters high voltage DC based on overhead transmission lines". International Journal of Emerging Electric Power Systems 22, nr 1 (24.12.2020): 61–72. http://dx.doi.org/10.1515/ijeeps-2020-0085.

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Abstract When a short-circuit fault occurs on the transmission lines of high voltage DC transmission system based on modular multilevel converters, the fault cannot be cleared by adjusting the converter control system, which results in longer recovery time. Aiming at the problem above, a fault self-clearing scheme based on the fault clearing module for the half-bridge converter station is proposed. Combined with the actual operating status of the flexible DC transmission project, centralized parameter models are utilized to analyze the fault self-clearing mechanism. Besides, the impact of the discharge branch on the fault clearing effect is studied in depth to provide a design consideration for the fault clearing module and improve the comprehensive benefits of the proposed scheme. PSCAD/EMTDC simulation results show that the introduction of the fault clearing module in the half-bridge converter station can effectively suppress the fault short-circuit current and shorten the fault clearing time. In addition, circuit breakers on both sides of the line do not need to be tripped, providing a reliable guarantee for the subsequent adaptive restart process.

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Yu, Jian, i Qiang Li. "Optimal Deployment in Moving Target Defense against Coordinated Cyber–Physical Attacks via Game Theory". Electronics 12, nr 11 (31.05.2023): 2484. http://dx.doi.org/10.3390/electronics12112484.

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This work proposes a method for the intelligent deployment of distributed flexible AC transmission system (D-FACTS) devices. In recent years, in the field of moving target defense (MTD) strategies to detect coordinated cyber–physical attacks (CCPAs), establishing how to deploy D-FACTS devices has become an important research point. Although some research results have been proposed, the obtained deployment solutions are unintelligent due to not carefully considering smart attackers’ behaviors. A method for achieving the intelligent deployment of D-FACTS devices is proposed in this paper. First, the basic concept of corrupting CCPAs is summarized; second, based on considering practical constraints and the basic concept, a protected transmission line set is confirmed; and third, a zero-sum game model is formulated, and a robust Nash equilibrium solution is computed. Due to the game’s characteristics, this solution reflects the smart attackers’ sense of action. Relying on the solution, those lines that are most likely to be tripped form a new protected transmission line set. Finally, a comprehensive algorithm using a metric proposed in previous studies is proposed for finding an intelligent solution for the deployment of D-FACTS devices. We validated our results through extensive simulations using IEEE 14-bus, 30-bus, and 118-bus power systems provided by MATPOWER and the real-world load profiles from New York State. Our work, in tracking the targets that attackers are most likely to attack, opens up new ideas for the intelligent deployment of D-FACTS devices.

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Wadjo, Hadibah Zachra. "PENCEMARAN NAMA BAIK DALAM PEMBERITAAN PERS". SASI 17, nr 2 (30.06.2011): 53. http://dx.doi.org/10.47268/sasi.v17i2.353.

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Development of the press or mass media today are influenced by several factors indicate changes in the face of the press or mass media ie, before delivering the news the press does not investigate the validity or subjects who reported whether true or not, obtained Press Publishing Business License (SIUUP) and improving the quality of journalism inadequate. Then the rise of new media including the Internet, multimedia technology, and next faces the press institutionalism practice that is due to pressure owners of capital, government pressure and pressure groups both internally and externally. Results showed, after the press tripped law have been regarded as preaching defame a person or group then the solution is still wearing articles of the Penal Code. It is not in line with what is desired by members of the press or mass media, because there are no rules that specifically regulates defamation committed by the press or mass media as well as Law No. 40 of 1999 on the Press, did not set any single article regarding defamation, only regulate the right of reply, rejected the right and the right correction.

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Barlas, Thanasis, Georg Raimund Pirrung, Néstor Ramos-García, Sergio González Horcas, Robert Flemming Mikkelsen, Anders Smærup Olsen i Mac Gaunaa. "Wind tunnel testing of a swept tip shape and comparison with multi-fidelity aerodynamic simulations". Wind Energy Science 6, nr 5 (6.10.2021): 1311–24. http://dx.doi.org/10.5194/wes-6-1311-2021.

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Abstract. One promising design solution for increasing the efficiency of modern horizontal axis wind turbines is the installation of curved tip extensions. However, introducing such complex geometries may move traditional aerodynamic models based on blade element momentum (BEM) theory out of their range of applicability. This motivated the present work, where a swept tip shape is investigated by means of both experimental and numerical tests. The latter group accounted for a wide variety of aerodynamic models, allowing us to highlight the capabilities and limitations of each of them in a relative manner. The considered swept tip shape is the result of a design optimization, focusing on locally maximizing power performance within load constraints. For the experimental tests, the tip model is instrumented with spanwise bands of pressure sensors and is tested in the Poul la Cour wind tunnel at the Technical University of Denmark (DTU). The methods used for the numerical tests consisted of a blade element model, a near-wake model, lifting-line free-wake models, and a fully resolved Navier–Stokes solver. The comparison of the numerical and the experimental test results is performed for a given range of angles of attack and wind speeds, which is representative of the expected conditions in operation. Results show that the blade element model cannot predict the measured normal force coefficients, but the other methods are generally in good agreement with the measurements in attached flow. Flow visualization and pressure distribution compare well with computational fluid dynamics (CFD) simulations. The agreement in the clean case is better than in the tripped case at the inboard sections. Some uncertainties regarding the effect of the boundary layer at the inboard tunnel wall and the post-stall behavior remain.

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Mehdipour, M., J. S. Kaastra i A. J. J. Raassen. "Line absorption of He-like triplet lines by Li-like ions". Astronomy & Astrophysics 579 (lipiec 2015): A87. http://dx.doi.org/10.1051/0004-6361/201526324.

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Wang, Gang, Gang Liu, Kai Wang, Yichen Li i Yinan Hu. "Tripability Analysis of Casing Strings in Directional Wells Using the Continuous Beam-Column and Buckling Theory". Geofluids 2022 (31.07.2022): 1–15. http://dx.doi.org/10.1155/2022/9728261.

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Hindered casing strings are often encountered in unconventional oil and gas exploration during the casing running process. This not only increases the operating costs and time but can also lead to downhole accidents and even abandonment in serious cases. Due to various assumptions, the calculation results of the existing soft models and hard models are different, which causes confusion for field operators when taking friction reduction measures. Moreover, a lowering force is often applied to assist hindered casing string running in a drilling field. However, its application is mainly based on work experience and lacks mechanistic analysis and theoretical guidance. Thus, in this study, a simulation model for the analysis of casing string tripability in a directional well was established and the model was combined with the continuous beam-column theory and buckling theory. The model was used to study how various factors including the friction coefficient, drilling fluid density, and casing diameter could affect the lowering force required when a casing string was hindered by buckling. The results showed that the maximum lowering force and the maximum effective lowering force decreased with the increase in the friction coefficient and the performance of the drilling fluid could be adjusted rapidly, which would be beneficial for ensuring that the casing string could be tripped smoothly by applying a lowering force. The increase in the drilling fluid density caused the maximum lowering force and the maximum effective lowering force to decrease, which was not conducive to hindered casing string running. The larger the casing diameter was, the greater the maximum lowering force and the maximum effective lowering force were. It was more convenient to apply a lowering force for a casing with a large diameter. In addition, the improved model could identify whether the casing string was in contact with the upper or lower borehole walls. Through finite element method verification, the prediction was in line with the actual casing running operation and the improved model has the smallest prediction error, i.e., 6.58%, compared with the existing models. Therefore, the improved model might provide necessary theoretical guidance for casing running operations in directional wells.

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Kim, Hyun-jung, i Ji-yoon Son. "A Study on Triple Bottom Line (TBL) Efficiency for Sustainable Operations of Airlines". Korean Review of Corporation Management 12, nr 4 (30.11.2021): 157–83. http://dx.doi.org/10.20434/kricm.2021.11.12.4.157.

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Campos, Fernanda Julio Barbosa, i Heidy Rodriguez Ramos. "Aplicação do Modelo Triple Bottom Line em um Hospital Público". Revista de Gestão Ambiental e Sustentabilidade 3, nr 1 (1.04.2014): 124–38. http://dx.doi.org/10.5585/geas.v3i1.148.

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Friedman, Alan D., Linsheng Zhang i Florence Bernardin Fried. "Cyclin-Dependent Kinase Phosphorylation of RUNX1/AML1 on Three Sites Increases Trans-Activation Potency and Stimulates Cell Proliferation." Blood 110, nr 11 (16.11.2007): 3351. http://dx.doi.org/10.1182/blood.v110.11.3351.3351.

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RUNX1/AML1 regulates lineage-specific genes during hematopoiesis and also stimulates G1 cell cycle progression. CBFβ-SMMHC or AML1-ETO dominantly inhibit RUNX1 and slow G1 progression in hematopoietic cell lines or in murine or human marrow progenitors, cdk4, cyclin D2, or c-Myc overcome inhibition of proliferation by these CBF oncoproteins, exogenous RUNX1 stimulates G1 progression, and stimulation of G1 via deletion of p16INK4a or expression of E7 cooperates with CBFβ-SMMHC or TEL-AML1 to induce acute leukemia in mice. Induction of cdk4 or cyclin D3 transcription may underlie stimulation of G1 progression by RUNX1. Remarkably, the C. elegans ortholog of RUNX1, RNT-1, also stimulates G1 progression and couples stem cell proliferation with differentiation. Not only does RUNX1 regulate cell cycle progression, but in addition RUNX1 levels increase as hematopoietic cells progress from G1 to S and from S to G2/M. Within RUNX1, S48, S303, and S424 fit the cdk phosphorylation consensus, (S/T)PX(R/K). Phosphorylation of RUNX1 by cyclin dependent kinases on serine 303 was shown to mediate destabilization of RUNX1 in G2/M. We now find that S48 and S424 are also phosphorylated by cdk1 or cdk6. S48, S303, or S424 phosphopeptide antiserum that we developed specifically recognized kinased GST-RUNX1 and interacted with RUNX1 expressed in 293T cells or in the Ba/F3 hematopoietic cell line. S48 phosphorylation of RUNX1 paralleled total RUNX1 levels during cell cycle progression, S303 was more effectively phosphorylated in G2/M, and S424 in G1. Single, double, and triple mutation to alanine or to the partially phosphomimetic aspartic acid progressively diminished or increased trans-activation, such that the tripleA mutant activated a RUNX1 reporter 5-fold less potently than the tripleD mutant. Aspartic acid does not perfectly mimic serine phosphorylation, as illustrated by the much greater affinity of our antisera for wild-type RUNX1 versus RUNX1(tripleD), suggesting that the biologic effect of RUNX1 cdk phosphorylation is even more significant. The p300 co-activator retained interaction with the tripleA variant. The tripleD RUNX1 mutant rescued Ba/F3 cells from inhibition of proliferation by CBFβ-SMMHC more effectively than the tripleA mutant. Cdk phosphorylation of RUNX1 on three sites increases its ability to active transcription and to stimulate proliferation, potentially coupling entry of stem/progenitors into cycle with induction of genes required for hematopoietic lineage progression, such as those encoding myeloperoxidase, neutrophil elastase, the M-CSF receptor, and PU.1.

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Prada Hurtado, Aníbal Antonio, Eduardo Martinez Carrasco, Maria Teresa Villén Martínez i Jose Saldana. "Application of IIA Method and Virtual Bus Theory for Backup Protection of a Zone Using PMU Data in a WAMPAC System". Energies 15, nr 9 (9.05.2022): 3470. http://dx.doi.org/10.3390/en15093470.

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Many wide area monitoring, protection, and control (WAMPAC) systems are being deployed by grid operators to deal with critical operational conditions that may occur in power systems. Thanks to the real-time measurements provided by a set of distributed phasor measurement units (PMUs), different protection algorithms can be run in a central location. In this context, this article presents and validates a novel method that can be used as a backup protection for a selected area in a power system. It merges the integrated impedance angle (IIA) protection method with the theory of virtual buses in wide area electrical power systems. The backup protection works this way: once a fault is detected (pickup time), another delay (added to the pickup time) is defined in order to wait for the primary protection to act. If this does not happen, the algorithm generates its backup trip. The proposed method has been called the zone integrated impedance angle (Zone IIA). A real-time PMU laboratory has been used to test the proposed algorithm using a real-time digital simulator (RTDS). The algorithm has been programmed in a real-time automation controller (RTAC). It has been tested in two different simulated setups: first, a 400 kV transmission system, with and without the use of renewable energy sources (RES); second, a 150 kV submarine line between the Greece mainland and an island, which is currently the longest submarine alternating current connection in the world. The results obtained during the tests have yielded tripping times for area protection in the order of 48 ms, if no time delay is used between the fault detection and the trip order. According to the test results, the proposed method is stable, reliable, obedient, and secure, also with RES installed in the power system. Additionally, the method is selective, i.e., during the tests no trip was executed for external faults, no trip was executed in no-fault condition, and all the applied internal faults were detected and tripped correctly. Finally, the protection method is easy to implement. The method is also applicable to protection against short circuits in distribution systems. According to the trip times observed during the tests, it is clear that these algorithms are well suited to implement backup protections in transmission grids, even in scenarios with high penetration of renewable energies. Considering that backup trip times in transmission grids are usually set between 400 and 1000 ms, and that the actuation times obtained by the proposed algorithm are under 100 ms, the method is suitable for its use as a backup protection.

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Green, Mark M., i Vipul Jain. "Homochirality in Life: Two Equal Runners, One Tripped". Origins of Life and Evolution of Biospheres 40, nr 1 (13.11.2009): 111–18. http://dx.doi.org/10.1007/s11084-009-9180-7.

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Martin, P., C. Lav�n i I. Martin. "Triplet-triplet transitions in zinc-like ions". Zeitschrift f�r Physik D Atoms, Molecules and Clusters 30, nr 4 (grudzień 1994): 279–84. http://dx.doi.org/10.1007/bf01426392.

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Gladstone, G. R. "Solar OI1304-Å triplet line profiles". Journal of Geophysical Research 97, A12 (1992): 19519. http://dx.doi.org/10.1029/92ja00991.

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Tanaka, S., i M. Nakagawa. "THE TRIPLET MEASURED BY AERIAL CAMERA USING LINE SEGMENTS LINE MATCHING-BASED RELATIVE ORIENTATION USING TRIPLET CAMERA". ISPRS - International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences XL-4/W5 (13.05.2015): 217–22. http://dx.doi.org/10.5194/isprsarchives-xl-4-w5-217-2015.

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In urgent observations after disasters, we can mention that the image matching processing is an essential technique to establish more stable and rapid 3D data generation. Particularly, multi-images taken from various viewpoints are useful in the disaster monitoring. Thus, feature and corresponded point detection would be designed for a multi-image matching. Recently, Structure from Motion (SfM) is often applied to generate 3D data. The SfM is useful approach to generate 3D data from images of random viewpoints. However, Scale-Invariant Feature Transform (SIFT) requires a plenty of time to detect feature points and corresponded points from multi-images. Therefore, we proposed a methodology to improve triplet matching and SfM with line segments extracted from images. Moreover, we evaluated our methodology using multi-images taken from aerial triplet camera.

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Carnes, Bud. "PM triples tool life". Metal Powder Report 56, nr 11 (listopad 2001): 10. http://dx.doi.org/10.1016/s0026-0657(01)80793-1.

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Hayashi, Toshinori, Alessandro A. Trani i Yasushi Suto. "Lagrange versus Lyapunov Stability of Hierarchical Triple Systems: Dependence on the Mutual Inclination between Inner and Outer Orbits". Astrophysical Journal 943, nr 1 (1.01.2023): 58. http://dx.doi.org/10.3847/1538-4357/acac1e.

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Abstract While there have been many studies examining the stability of hierarchical triple systems, the meaning of “stability” is somewhat vague and has been interpreted differently in previous literatures. The present paper focuses on “Lagrange stability,” which roughly refers to the stability against the escape of a body from the system, or “disruption” of the triple system, in contrast to “Lyapunov-like stability,” which is related to the chaotic nature of the system dynamics. We compute the evolution of triple systems using direct N-body simulations up to 107 P out, which is significantly longer than previous studies (with P out being the initial orbital period of the outer body). We obtain the resulting disruption timescale T d as a function of the triple orbital parameters with particular attention to the dependence on the mutual inclination between the inner and outer orbits, i mut. By doing so, we have clarified explicitly the difference between Lagrange and Lyapunov stabilities in astronomical triples. Furthermore, we find that the von Zeipel–Kozai–Lidov oscillations significantly destabilize inclined triples (roughly with 60° 160° become strongly stabilized with much longer disruption timescales. We show the sensitivity of the normalized disruption timescale T d/P out to the orbital parameters of triple system. The resulting T d/P out distribution is practically more useful in a broad range of astronomical applications than the stability criterion based on the Lyapunov divergence.

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Mañas, Antonio Vico, Arnoldo De Hoyos, Bia Telles i Diego Conti. "The Critical Shift from a Consumer to a More Sustainable Society". Journal on Innovation and Sustainability. RISUS ISSN 2179-3565 2, nr 1 (18.10.2011): 87. http://dx.doi.org/10.24212/2179-3565.2011v2i1p87-97.

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This paper looks forward to analyzing the society industrialization period, considering factors like consumption, urbanization, social changes, global capitalism and the modern society. Starting from the Industrial Revolution, the author discuss ideas, events and the evolution of the Sustainable Development principles in particular concerning and social concerns as a way to deal with challenges regarding quality of life on today’s megalopolis. For Governance purposes regarding Sustainability, it is suggested the creation of an international network forum with appropriate representatives from the triple bottom line of sustainable development.

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Bormashenko, Edward. "Entropy Contribution to the Line Tension: Insights from Polymer Physics, Water String Theory, and the Three-Phase Tension". Entropy 20, nr 9 (16.09.2018): 712. http://dx.doi.org/10.3390/e20090712.

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The notion of three-phase (line) tension remains one of the most disputable notions in surface science. A very broad range of its values has been reported. Experts even do not agree on the sign of line tension. The polymer-chain-like model of three-phase (triple) line enables rough estimation of entropic input into the value of line tension, estimated as Γ e n ≅ k B T d m ≅ 10 − 11 N , where d m is the diameter of the liquid molecule. The introduction of the polymer-chain-like model of the triple line is justified by the “water string” model of the liquid state, predicting strong orientation effects for liquid molecules located near hydrophobic moieties. The estimated value of the entropic input into the line tension is close to experimental findings, reported by various groups, and seems to be relevant for the understanding of elastic properties of biological membranes.

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Brown, Jessica A., Charles G. Kinzig, Suzanne J. DeGregorio i Joan A. Steitz. "Methyltransferase-like protein 16 binds the 3′-terminal triple helix of MALAT1 long noncoding RNA". Proceedings of the National Academy of Sciences 113, nr 49 (21.11.2016): 14013–18. http://dx.doi.org/10.1073/pnas.1614759113.

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Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), a cancer-promoting long noncoding RNA, accumulates in cells by using a 3′-triple-helical RNA stability element for nuclear expression (ENE). The ENE, a stem-loop structure containing a U-rich internal loop, interacts with a downstream A-rich tract (ENE+A) to form a blunt-ended triple helix composed of nine U•A-U triples interrupted by a C•G-C triple and C-G doublet. This unique structure prompted us to explore the possibility of protein binding. Native gel-shift assays revealed a shift in radiolabeled MALAT1 ENE+A RNA upon addition of HEK293T cell lysate. Competitive gel-shift assays suggested that protein binding depends not only on the triple-helical structure but also its nucleotide composition. Selection from the lysate using a biotinylated-RNA probe followed by mass spectrometry identified methyltransferase-like protein 16 (METTL16), a putative RNA methyltransferase, as an interacting protein of the MALAT1 ENE+A. Gel-shift assays confirmed the METTL16–MALAT1 ENE+A interaction in vitro: Binding was observed with recombinant METTL16, but diminished in lysate depleted of METTL16, and a supershift was detected after adding anti-METTL16 antibody. Importantly, RNA immunoprecipitation after in vivo UV cross-linking and an in situ proximity ligation assay for RNA–protein interactions confirmed an association between METTL16 and MALAT1 in cells. METTL16 is an abundant (∼5 × 105 molecules per cell) nuclear protein in HeLa cells. Its identification as a triple-stranded RNA binding protein supports the formation of RNA triple helices inside cells and suggests the existence of a class of triple-stranded RNA binding proteins, which may enable the discovery of additional cellular RNA triple helices.

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Reddy, Sangeetha M., Meredith Carter, Isaac Chan, Melanie Hullings, Nisha Unni, Jessica Medina, Shahbano Shakeel i in. "Phase 1 pilot study with dose expansion of chemotherapy in combination with CD40 agonist and Flt3 ligand in metastatic triple-negative breast cancer." Journal of Clinical Oncology 40, nr 16_suppl (1.06.2022): TPS1126. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.tps1126.

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TPS1126 Background: Only a subset of patients with metastatic triple-negative breast cancer demonstrate response to currently approved PD-1 immune checkpoint blockade, and few have durable responses. Antigen presentation defects may be a reason for this low response because deficiency of antigen-presenting DC1 dendritic cells is associated with poor anti-tumor immunity. CD40 agonists are a class of agents that activate antigen presenting cells including dendritic cells and B cells and also repolarize macrophages. Flt3 ligand is a growth factor that increases dendritic cells. In line with this, we recently demonstrated in pre-clinical models that the combination of liposomal-doxorubicin chemotherapy, a CD40 agonist, and a Flt3 ligand improves outcomes of breast cancer compared to alternate combinations. Methods: This is a single arm phase I pilot study of liposomal-doxorubicin, CDX-1140 (CD40 agonist), and CDX-301 (Flt3 ligand) combination therapy in patients with metastatic or unresectable locally advanced metastatic triple-negative breast cancer. Patients will be randomized to 3 lead-in arms (triplet therapy, doublet immunotherapy only, liposomal-doxorubicin only) prior to receiving full triplet therapy with fresh tissue biopsies before and after the lead-in treatment. CDX-301 will be discontinued after 2 cycles; liposomal-doxorubicin and CDX-1140 will be continued until disease progression or clinically limiting toxicities. Primary endpoint is determination of a recommended phase 2 dose based on treatment-related adverse events including dose-limiting toxicities. Secondary endpoints include anti-tumor immune response after triplet therapy, after immunotherapy alone, and after liposomal-doxorubicin alone; median progression-free survival, overall response rate, duration of response, and clinical benefit rate. Key eligibility criteria are unresectable stage III or stage IV triple-negative breast cancer (ER ≤10%, PR ≤10%, HER2/neu negative), 1st to 3rd line metastatic treatment setting (1st line patients need to be PD-L1 negative by 22C3 assay), measurable disease by RECIST 1.1 criteria, consent for pre-treatment and on-treatment biopsies of amenable soft tissue tumor lesions, no prior treatment with an anti-CD40 antibody or a Flt3 ligand, no anthracycline treatment in the metastatic setting, no prior progression while on anthracycline-based therapy or within 6 months of completing neoadjuvant chemotherapy, and no history of non-infectious pneumonitis or current pneumonitis. This trial will enroll up to 45 patients across multiple sites. Clinical trial information: NCT05029999.

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Ding, Ji, Tao Zhang i Jianfeng Li. "Compact in-line triplet SIW bandpass filter using etched GCPW line resonator". IEICE Electronics Express 13, nr 4 (2016): 20151120. http://dx.doi.org/10.1587/elex.13.20151120.

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Ness, J. U., R. Mewe, J. H. M. M. Schmitt, A. J. J. Raassen, D. Porquet, J. S. Kaastra, R. L. J. van der Meer, V. Burwitz i P. Predehl. "Helium-like triplet density diagnostics". Astronomy & Astrophysics 367, nr 1 (luty 2001): 282–96. http://dx.doi.org/10.1051/0004-6361:20000419.

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Zhao, Bing Bing, Lasar S. Shvindlerman i Günter Gottstein. "Grain Boundary Triple Line Tension in Copper". Materials Science Forum 715-716 (kwiecień 2012): 843–48. http://dx.doi.org/10.4028/www.scientific.net/msf.715-716.843.

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The current study introduces a thermodynamically correct approach which allows a direct precise measurement of the grain boundary triple line tension. The experimental technique utilizes the measurement of the surface topography of a crystal in the vicinity of a triple junction and grain boundary groove on thin wires by atomic force microscopy. The grain boundary triple line tension of a random triple line was measured to be in the order of 10-9J/m.

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Hasegawa, Yasumasa, Kazushige Machida i Masa-aki Ozaki. "Spin-Triplet Superconductivity with Line Nodes in Sr2RuO4". Journal of the Physical Society of Japan 69, nr 2 (15.02.2000): 336–39. http://dx.doi.org/10.1143/jpsj.69.336.

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Lee, Seong-Doo, Soon-Ho Choi, Chan-Ki Kim i HanJu Cha. "A Study on the Design of Triple-tuned Filter for Line Commutated Converter HVDC". Transactions of The Korean Institute of Electrical Engineers 64, nr 9 (1.09.2015): 1288–96. http://dx.doi.org/10.5370/kiee.2015.64.9.1288.

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Cardoso Abdala, Etienne, Eder J. de Oliveira i Luciana Oranges Cezarino. "Triple bottom line in Green Supply Chain Management: a chemical industry study". Brazilian Journal of Operations & Production Management 15, nr 1 (28.01.2018): 162–72. http://dx.doi.org/10.14488/bjopm.2018.v15.n1.a15.

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The management of the green supply chain aims to add practices to preserve the environment in the integrated network of supplies, in order to minimize the use of natural resources and to increase the use of the reuse of materials. The purpose of this article is to identify sustainable practices used by chemical industries of the Triple Bottom Line. Semi-structured interviews were carried out with mangers of medium and small business enterprises. Results show that sustainability is present in both; however, not fully completely obeying the sustainability tripod concept. The medium-sized company has a higher development of its environmental practices and could be considered as a focal company between the supply chain and their suppliers. Small businesses have to develop strategies, especially in terms of providing legal compliance to maintain their partnership with suppliers. None of them performed literature practices of a Green Supply Chain, but the first company, medium sized is ahead in terms of sustainable practices.

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Sudhakar, Ambarapu, Gaddi Nagasai, Modala Prudhvi Sagar, Maya Vamshi, Vasala Nikhil i Bodapati Venkata Rajanna. "Transmission line fault analysis using actuating relays and Atmega 328P controller". International Journal of Applied Power Engineering (IJAPE) 12, nr 2 (1.06.2023): 190. http://dx.doi.org/10.11591/ijape.v12.i2.pp190-195.

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Since transmission lines account for 80–86% of power system problems, protecting transmission lines is a critical concern. This research proposes a method to identify and categorize various short circuit defects on transmission lines. Various operational and fault circumstances on the transmission of high voltage lines, including L-L fault, single phase to earth fault, and double line fault, double line Three fault scenarios triple line fault, triple line to ground fault, and triple line are simulated using MATLAB software. These flaws damage the linked devices to the power grid. The main motto of this work is to analyze various kinds of faults and also to detect the type of the fault in transmission line. In order to simulate and evaluate the various faults, a 100 km transmission line model was created. A sim power system block library had a fault block, and the harmonic content of the various faults was studied using the FFT tool, the effect of faults was observed. Based on the analysis, a hardware model is designed to identify the faults in transmission line using actuating relays and Atmega 328P microcontroller and display the fault type and parameters like fault impedance, and distance at which fault occurred.

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Shawl, Sana, Keyurkumar M. Nayak i Nakul Gupta. "Cello Plastotech: adopting the triple bottom line as a sustainability strategy". Emerald Emerging Markets Case Studies 13, nr 1 (30.05.2023): 1–18. http://dx.doi.org/10.1108/eemcs-09-2021-0294.

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Learning outcomes On completion of the case, the students will be able to understand the concept and importance of sustainability; understand how triple bottom line can help a company make a transition towards sustainability; evaluate the tensions between the three pillars of triple bottom line approach; assess the role of circular economy model as opposed to the conventional linear model in the transition of a company towards sustainability; and understand the sustainability challenge in an emerging market context. Case overview/synopsis Despite the promising growth potential of the plastics industry in India, it is faced with sustainability challenges owing to its detrimental impact on environment. To preserve the environment and human kind, the government made a bold announcement in 2018 to eliminate the use of highly polluting single-use plastics (SUPs) in the country. Amid this growing sustainability threat against plastics and the fall in demand of SUP items, this case illustrates that Sandip Patel, the plant manager of Cello Plastotech, is entrusted by the CEO with the responsibility of adopting a triple bottom line approach encompassing its three pillars, that is, people, planet and profits, as a response to the sustainability challenge. The strategic rethinking towards adopting sustainability required Patel to face the challenge of striking a balance between the three pillars of triple bottom line while also taking some valuable insights for plastic waste management from the circular economy model. While making a transition to sustainability, he needed to evaluate different options like stopping the manufacture of SUPs and look for alternatives, use of biodegradable raw material which was expensive but environment friendly or manufacture such durable plastic products that would replace SUPs. Complexity academic level The case is aimed at teaching the topic Triple Bottom Line approach in the courses of business strategy and sustainability in under-graduate and post-graduate level courses in the discipline of Management. It can also be used as a supplementary reading in courses like Corporate Social Responsibility and Circular Economy. In emerging markets’ context, these topics are generally taught to MBA students in courses like strategic management, sustainable business and business ethics. Supplementary materials Teaching notes are available for educators only. Subject code CSS 11: Strategy.

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Lestienne, Patrick P. "Priming DNA Replication from Triple Helix Oligonucleotides: Possible Threestranded DNA in DNA Polymerases". Molecular Biology International 2011 (14.09.2011): 1–9. http://dx.doi.org/10.4061/2011/562849.

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Triplex associate with a duplex DNA presenting the same polypurine or polypyrimidine-rich sequence in an antiparallel orientation. So far, triplex forming oligonucleotides (TFOs) are known to inhibit transcription, replication, and to induce mutations. A new property of TFO is reviewed here upon analysis of DNA breakpoint yielding DNA rearrangements; the synthesized sequence of the first direct repeat displays a skewed polypurine- rich sequence. This synthesized sequence can bind the second homologous duplex sequence through the formation of a triple helix, which is able to prime further DNA replication. In these case, the d(G)-rich Triple Helix Primers (THP) bind the homologous strand in a parallel manner, possibly via a RecA-like mechanism. This novel property is shared by all tested DNA polymerases: phage, retrovirus, bacteria, and human. These features may account for illegitimate initiation of replication upon single-strand breakage and annealing to a homologous sequence where priming may occur. Our experiments suggest that DNA polymerases can bind three instead of two polynucleotide strands in their catalytic centre.

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Fionda, Valeria, i Giuseppe Pirrò. "Learning Triple Embeddings from Knowledge Graphs". Proceedings of the AAAI Conference on Artificial Intelligence 34, nr 04 (3.04.2020): 3874–81. http://dx.doi.org/10.1609/aaai.v34i04.5800.

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Graph embedding techniques allow to learn high-quality feature vectors from graph structures and are useful in a variety of tasks, from node classification to clustering. Existing approaches have only focused on learning feature vectors for the nodes and predicates in a knowledge graph. To the best of our knowledge, none of them has tackled the problem of directly learning triple embeddings. The approaches that are closer to this task have focused on homogeneous graphs involving only one type of edge and obtain edge embeddings by applying some operation (e.g., average) on the embeddings of the endpoint nodes. The goal of this paper is to introduce Triple2Vec, a new technique to directly embed knowledge graph triples. We leverage the idea of line graph of a graph and extend it to the context of knowledge graphs. We introduce an edge weighting mechanism for the line graph based on semantic proximity. Embeddings are finally generated by adopting the SkipGram model, where sentences are replaced with graph walks. We evaluate our approach on different real-world knowledge graphs and compared it with related work. We also show an application of triple embeddings in the context of user-item recommendations.

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Norman, Wayne, i Chris MacDonald. "Getting to the Bottom of “Triple Bottom Line”". Business Ethics Quarterly 14, nr 2 (kwiecień 2004): 243–62. http://dx.doi.org/10.5840/beq200414211.

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Abstract:In this paper, we examine critically the notion of “Triple Bottom Line” accounting. We begin by asking just what it is that supporters of the Triple Bottom Line idea advocate, and attempt to distil specific, assessable claims from the vague, diverse, and sometimes contradictory uses of the Triple Bottom Line rhetoric. We then use these claims as a basis upon which to argue (a) that what is sound about the idea of a Triple Bottom Line is not novel, and (b) that what is novel about the idea is not sound. We argue on both conceptual and practical grounds that the Triple Bottom Line is an unhelpful addition to current discussions of corporate social responsibility. Finally, we argue that the Triple Bottom Line paradigm cannot be rescued simply by attenuating its claims: the rhetoric is badly misleading, and may in fact provide a smokescreen behind which firms can avoid truly effective social and environmental reporting and performance.

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van de Schootbrugge, Chantal, Freekje van Asten, Iris D. Nagtegaal, Yvonne M. Versleijen-Jonkers, Hanneke W. M. van Laarhoven, Melissa H. Roeffen, Fred C. G. J. Sweep i in. "αB-Crystallin Expression is Correlated with Phospho-ERK1/2 Expression in Human Breast Cancer". International Journal of Biological Markers 28, nr 4 (październik 2013): 365–70. http://dx.doi.org/10.5301/jbm.5000032.

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αB-crystallin is regarded as a biomarker for triple-negative and/or basal-like breast cancer. In normal breast cells, over-expression of αB-crystallin leads to neoplastic-like changes, which likely relate to enhanced expression of phosphorylated ERK1/2 (pERK1/2). In this study, we investigated whether αB-crystallin expression is correlated to pERK1/2 expression in breast cancer. In a balanced tissue microarray the expression of αB-crystallin and pERK1/2 kinase were determined immunohistochemically, together with the triple-negativity and basal-like markers CK5/6 and SMA and the signaling molecules pAKT, pmTOR, EGFR, and IGF-1R. αB-crystallin expression significantly correlated with triple negativity and basal-like markers CK5/6 and SMA (Pearson Chi-square test p=0.004, p=0.001, and p<0.001, respectively). A significant correlation was also observed with pERK1/2 expression (p=0.002). siRNA-mediated knockdown of αB-crystallin in the triple-negative breast cell line MDA-MB468 did not show an effect on pERK1/2 expression levels, indicating that lowering the level of αB-crystallin does not reduce pERK1/2 expression. Our results confirm that αB-crystallin can be used as a biomarker for triple-negative and/or basal-like breast cancer. The expression of αB-crystallin correlates with pERK1/2 expression in breast cancer tissue suggesting that therapies targeting αB-crystallin might be considered for treatment of triple-negative or basal-like breast cancer.

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Torabi, Seyed-Fakhreddin, Suzanne J. DeGregorio i Joan A. Steitz. "tRNA-like leader-trailer interaction promotes 3′-end maturation of MALAT1". RNA 27, nr 10 (12.07.2021): 1140–47. http://dx.doi.org/10.1261/rna.078810.121.

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Human metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a nuclear long noncoding RNA (lncRNA) that is highly overexpressed in many cancer tissues and plays important roles in tumor progression and metastasis. The MALAT1 primary transcript contains evolutionarily conserved structural elements in its 3′-terminal region: a triple helix forming element called element for nuclear expression (ENE) and a downstream tRNA-like structure called mascRNA. Instead of being polyadenylated, mature MALAT1 is generated by recognition and processing of the mascRNA by RNase P. A genomically encoded A-rich tract at the new 3′ end of MALAT1, which is generated upon RNase P cleavage, forms a triple helical structure with the upstream ENE. Triplex formation is vital for stabilization of the mature transcript and for subsequent accumulation and oncogenic activity of MALAT1. Here, we demonstrate that efficient 3′-end maturation of MALAT1 is dependent on an interaction between the A-rich tract and the mascRNA 3′ trailer. Using mutational analyses of cell-based reporter accumulation, we show that an extended mascRNA acceptor stem and formation of a single bulged A 5′ to the RNase P cleavage site are required for efficient maturation of the nascent MALAT1 3′ end. Our results should benefit the development of therapeutic approaches to cancer through targeting MALAT1.

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Newhouse, E. Irene, i Raoul Kopelman. "Fractal-like triplet-triplet annihilation kinetics in naphthalene-doped poly(methylmethacrylate)". Chemical Physics Letters 143, nr 1 (styczeń 1988): 106–10. http://dx.doi.org/10.1016/0009-2614(88)87020-9.

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Laine, Loren. "Is It Time for Quadruple Therapy to be First Line?" Canadian Journal of Gastroenterology 17, suppl b (2003): 33B—35B. http://dx.doi.org/10.1155/2003/303528.

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The most commonly used regimen forHelicobacter pyloritherapy at present is twice-daily proton pump inhibitor (PPI)-based triple therapy. Bismuth-based therapy is the next most common treatment used by gastroenterologists. When a PPI is combined with bismuth-based triple therapy (quadruple therapy), eradication rates are increased as compared with the triple therapy alone. Three separate randomized trials from three continents that compare quadruple therapy and PPIbased triple therapy revealed remarkably similar results. Eradication rates with PPI-based triple therapy and quadruple therapy were not significantly different. The eradication rates with quadruple therapy were 3% to 6% higher than PPI triple therapy, indicating that quadruple therapy should be no less effective than PPI triple therapy. Furthermore, these two therapies had similar rates of compliance and adverse events.The major potential benefit of the quadruple therapy relates to antibiotic resistance. In patients with clarithromycin resistance, PPIbased triple therapy, but not quadruple therapy, had a significantly lower eradication rate. However, due to its ability to largely overcome metronidazole resistance, quadruple therapy had little if any decrement in eradication rates compared with PPI triple therapy in patients with metronidazole-resistantH pylori. Therefore, quadruple therapy can be considered a first line therapy forH pylori.

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45

Guo, Tianqi, Muchen Li, Liping Heng i Lei Jiang. "Design of honeycomb structure surfaces with controllable oil adhesion underwater". RSC Advances 5, nr 76 (2015): 62078–83. http://dx.doi.org/10.1039/c5ra10514e.

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We fabricate honeycomb-like poly acrylic acid (PAA) surfaces and achieve oil adhesion regulation underwater by changing the pore size and the solution pH, which affect triple-phase contact line (TCL) continuity and the negative pressure in the pores.

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46

Gereben, Orsolya, i László Pusztai. "The like-like-like partial triplet correlation functions of amorphous Ni62Nb38". Journal of Non-Crystalline Solids 205-207 (październik 1996): 716–20. http://dx.doi.org/10.1016/s0022-3093(96)00298-0.

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Hanna, Diana, Gayle S. Jameson, Drew W. Rasco, Angela Alistar, Richard C. Frank, Anthony B. El-Khoueiry, Julia E. Wiedmeier i in. "Abstract CT549: Randomized Phase II trial of two different nutritional approaches for patients receiving treatment for their advanced pancreatic cancer". Cancer Research 82, nr 12_Supplement (15.06.2022): CT549. http://dx.doi.org/10.1158/1538-7445.am2022-ct549.

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Abstract Background: Pancreatic ductal adenocarcinoma (PDAC) is characterized by stromal fibrosis, hypoxia, and nutritional deprivation. PDAC tumors grow aggressively, diagnosis is typically made after metastasis and the disease remains associated with poor outcomes. The triplet chemotherapy regimen of gemcitabine, nab-paclitaxel with cisplatin was associated with a median overall survival of 16.4 months in patients with metastatic pancreatic cancer in the first-line setting (Jameson et al., 2020). Nutritional, metabolic interventions offer an opportunity to fundamentally change the tumor microenvironment and improve outcomes for patients. A medically supervised ketogenic diet (MSKD) defined as lower carbohydrate, lower protein, and higher fat can significantly reduce glucose and insulin and increase metabolically active ketone bodies. A ketogenic diet combined with triplet chemotherapy (gemcitabine, nab-paclitaxel, cisplatin) was shown to inhibit murine pancreatic KPC tumor growth and to triple the survival benefit of chemotherapy alone. The ketogenic diet combined with triple chemotherapy was associated with glucose depletion, altered TCA substrate usage, and NADH elevation. Methods: In this Phase II randomized clinical trial (NCT04631445), we are evaluating a medically supervised ketogenic diet (MSKD) versus a standard diet when combined with the triplet therapy in patients with treatment-naive advanced pancreatic cancer. The primary endpoint is progression free survival for triplet therapy while on MSKD or non-MSKD. Secondary endpoints include disease control rate (PR+ CR+ SD for at least 9 weeks), change in CA 19-9 (or CA125, or CEA if not expressers of CA 19-9), average insulin levels, HbA1c, body weight, a comparison of gut microbial diversity, changes in serum metabolites and quality of life via the EORTC QLQ-C30 assessment. Unlike prior ketogenic intervention studies, the MSKD is being supported by a continuous care nutrition intervention through Virta Health Corp, that offers tracking of daily ketone and glucose levels, a web-based software application, education, and communication with a remote care team to ensure sustained nutritional ketosis. A total of 40 patients with untreated metastatic PDAC are planned for enrollment, 20 randomized to each arm. The trial opened for accrual November 2020. Citation Format: Diana Hanna, Gayle S. Jameson, Drew W. Rasco, Angela Alistar, Richard C. Frank, Anthony B. El-Khoueiry, Julia E. Wiedmeier, Caroline Roberts, Brandon Fell, Sarah Hallberg, Denise Roe, Derek Cridebring, Joshua Rabinowitz, Stephen Thomas Gately, Daniel D. Von Hoff. Randomized Phase II trial of two different nutritional approaches for patients receiving treatment for their advanced pancreatic cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr CT549.

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Sandy, Sandy, Murtafia Murtafia i Gina Lucita. "Management of Tourism Villages Using the Triple Bottom Line Concept". Jurnal Ad'ministrare 9, nr 2 (27.12.2022): 679. http://dx.doi.org/10.26858/ja.v9i2.41720.

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Tourism villages have emerged as a viable option for local economic development and community welfare. As a result, the development of tourist villages has become a national initiative. The purpose of this research is to examine the accomplishments of a tourist village's management using the triple bottom line concept. Nonongan Selatan Tourism Village in North Toraja Regency and Kolesawangan Tourism Village in Tana Toraja Regency were chosen as research sites. The data for this study was gathered using a qualitative method, including interviews, observation, and document analysis. The findings of this study show that the Tourism Village Concept, as applied to Lembang Nonongan Selatan Village, which emphasizes people's daily lives, and Lembang Kole Sawangan Village, which emphasizes historical tourist destinations, has reflected the Triple Bottom Line Concept, which is measured in three areas: profit, people, and planet. This demonstrates that the concept of a tourist village is consistent with the government's goals, which are to improve the quality of life and welfare of the community while maintaining environmental quality. Keywords: Tourism village, sustainable economy, triple bottom line

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Guo, Hong, i Alan D. Friedman. "Phosphorylation of RUNX1 by Cyclin-Dependent Kinase Reduces Direct Interaction with HDAC1 and HDAC3 and Stimulates Marrow Progenitor Proliferation." Blood 114, nr 22 (20.11.2009): 2508. http://dx.doi.org/10.1182/blood.v114.22.2508.2508.

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Abstract Abstract 2508 Poster Board II-485 RUNX1 helps direct the formation of definitive HSC during embryogenesis and the subsequent maturation of the lymphoid, myeloid, and megakaryocytic lineages in adults. RUNX1 regulates both lineage-specific genes and G1 to S cell cycle progression, the latter in part via induction of cyclin D3 and cdk4 transcription. Recent studies demonstrate that RUNX1 homologs in sea urchin blastocyts or in C. elegans seam cells, a stem cell subset, also stimulate cell proliferation. Of note, RUNX1 activities are commonly perturbed in human AML or ALL cases. RUNX1 residues S48, S303, and S424 fit the consensus, (S/T)PX(R/K), for phosphorylation by cyclin dependent kinases (cdk). Mutation of these residues to the phosphomimetic aspartic acid increases RUNX1 trans-activation, and mutation to alanine reduces trans-activation, without perturbing p300 interaction (Zhang et al 2008). We now demonstrate that cdk phosphorylation of RUNX1 reduces its interaction with HDAC1 and HDAC3. First, co-immunoprecipitation of FLAG-tagged HDAC1 or HDAC3 with myc-tagged RUNX1, RUNX1(tripleA), with S48, S303, and S424 mutated to alanine, or RUNX1(tripleD), with these three residues mutated to aspartic acid, was assessed using extracts from transiently transfected 293T cells. Both HDAC1 and HDAC3 bound RUNX1(tripleD) with greatly reduced affinity compared to RUNX1 or its tripleA variant. Consistent with previous mapping of HDAC1 and HDAC3 interaction to the C-terminal residues 380–432 of RUNX1, when this same assay was repeated using RUNX1(S48D), RUNX1(S303D), or RUNX1(S424D), carrying single residue mutations to aspartic acid, only S424D reduced HDAC1 binding, and S424D had a greater effect than S48D or S303D on HDAC3 binding. Second, when GST-RUNX1, GST-RUNX1(424A), or GST-RUNX1(424D) fusion proteins isolated from bacteria were incubated with in vitro translated, S35-methionine labeled HDAC1 or HDAC3, reduced interaction was again seen to the 424D variant. Finally, incubation of wild-type GST-RUNX1 with cdk1/cyclinB led to reduced interaction with radio-labeled HDAC1 or HDAC3, indicating that cdk phosphorylation and not just change of cdk target residues to aspartic acid reduces HDAC binding to RUNX1. In addition, endogenous HDAC1 in the Ba/F3 hematopoietic cell line co-immunoprecipitated with exogenous RUNX1, and we are attempting to optimize methods to detect interaction between the endogenous proteins. We previously provided data suggesting that RUNX1 cdk phosphorylation stimulates proliferation of the Ba/F3 hematopoietic cell line (Zhang et al 2008). We now find that RUNX1 or RUNX1(tripleD) reproducibly stimulate proliferation of transduced, lineage-negative murine marrow progenitors more potently than RUNX1(tripleA). Together our findings indicate that stimulation of RUNX1 trans-activation activity by cdk-mediated reduction in direct HDAC1 and HDAC3 interaction facilitates hematopoietic progenitor cell proliferation. Future studies will endeavor to determine whether activation of cdk in HSC or myeloid progenitors, for example by Notch or Wnt signaling, stimulates RUNX1 cdk phosphorylation to facilitate induction of cell cycle regulatory genes and cell proliferation. Conversely, reduced RUNX1 cdk phosphorylation may facilitate HSC quiescence. Disclosures: No relevant conflicts of interest to declare.

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50

Suba, János. "A trianoni hármashatárok kijelölése". Jelenkori Társadalmi és Gazdasági Folyamatok 4, nr 3-4 (1.01.2009): 276–81. http://dx.doi.org/10.14232/jtgf.2009.3-4.276-281.

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A "triple" or "tergeminate" frontier is the meeting point of the frontiers of three neighbouring countries. The boundary stone which marks it, named "triplex confinum", is generally a monumental, obelisk-like work of art. Along the frontiers of Hungary, estab-lished by the Trianon Peace Treaty and traced out on the terrain, there were four such triplex confinia. Their establishing and indication was done as a result of long negotiations and without the knowledge of the Hungarian party sometimes. The study treats the political efforts in this concern and explains how the location of the tergeminate frontier marks have been positioned, together with the presentation of the different types of the monuments. It is worth mentioning that no one of the original four Trianon tergeminate frontier marks are standing on their primary places today.

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