Rozprawy doktorskie: „Transplantation of organs, tissue”

1

Chudik, John D. "Human fetal tissue transplantation an Orthodox Christian ethical evaluation /". Theological Research Exchange Network (TREN), 1994. http://www.tren.com.

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Van, den Berg Leon. "Organ and tissue donation and transplantation a perspective of South African Baptists from the Baptist Northern Association and its implications for preaching /". Pretoria : [s.n.], 2006. http://upetd.up.ac.za/thesis/available/etd-10022007-164428/.

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Pummer-Verté, Lila. "Organ donation and transplantation /". Online version of thesis, 1995. http://hdl.handle.net/1850/12252.

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Bedaiwy, Mohamed Ali. "Ovarian tissue cryopreservation and transplantation : approaches and techniques /". Cleveland, Ohio : Cleveland Clinic, 2007. http://www.loc.gov/catdir/toc/ecip082/2007042633.html.

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Waln, Donna L. "The ethics of fetal tissue research and transplant". Theological Research Exchange Network (TREN), 1998. http://www.tren.com.

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Nikkhah, Guido. "Microtransplantation of nigral dopamine neurons in a rat model of Parkinson's disease studies on functional recovery and structural repair in adult and neonatal rats with lesions of the mesotelencephalic dopamine system /". Lund : Dept. of Medical Cell Research, Lund University, 1994. http://catalog.hathitrust.org/api/volumes/oclc/39693821.html.

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7

Wotherspoon, John Scott. "Studies in transplantation tolerance". Thesis, The University of Sydney, 1990. https://hdl.handle.net/2123/26352.

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The most fundamental function of the immune system is discrimination between the molecules that constitute "self" and those of foreign organisms, tissues or substances which the organism encounters during life. This immunological discrimination between self and non-self is vital to the maintenance of the biological integrity of the organism and is evident at the lowest phylogenetic levels (Hildemann et al., 1977). Encounters with molecules which are recognised as non-self trigger the immune system to initiate effector mechanisms by which the foreign molecules are eliminated. The diverse range of self molecules, however, does not apparently induce a similar response. The lack of responsiveness to self molecules, so called self-tolerance, is thought to be acquired during the development of the lymphoid system. As yet, the actual process by which the immune system distinguishes self and non-self molecules is not fully understood and remains a central issue of cellular immunology.

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8

Motallebzadeh, Reza. "Tertiary lymphoid organogenesis in solid organ transplantation". Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608121.

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Crouch, Robert Alan. "The child as tissue and organ donor". Thesis, McGill University, 1996. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=23714.

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This thesis attempts to answer the following question: Is it ever morally permissible to use a minor child as a tissue or organ donor for the benefit of a family member? Those sceptical of using minors as tissue or organ donors for the benefit of a sick family member will highlight two points: the donor will be subject to risks that are not counterbalanced by possible medical benefits, and the minor cannot consent to the procedure herself.
This thesis will present a review of the medical risks associated with bone marrow and kidney donations, as well as a review of the common law dealing with donations by minors and incompetent persons. The final chapter then makes a case for the permissibility of minor donation based on the interests of the family.

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Fisher, Karen Joan. "Allocating scarce resources an ethical case study of organ transplantation /". Theological Research Exchange Network (TREN), 1997. http://www.tren.com.

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Shubane, Nancy. "Black critical care nurses' perceptions of organ donation and organ transplantation". Pretoria : [s.n.], 2009. http://upetd.up.ac.za/thesis/available/etd-10262009-185326/.

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Zheng, Ling 1958. "Airway inflammation and remodelling post human lung transplantation". Monash University, Dept. of Medicine, 2002. http://arrow.monash.edu.au/hdl/1959.1/8099.

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Nagel, Markus. "Organtransplantation und Internationales Privatrecht". Berlin ; Heidelberg : Springer, 2009. http://deposit.d-nb.de/cgi-bin/dokserv?id=3182142&prov=M&dok%5Fvar=1&dok%5Fext=htm.

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Wong, Mei-yi, i 王美兒. "Improving engraftment potential of hMSCs after encapsulation in collagen microsphere: an in vitro and in vivostudy". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B47753080.

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Stem cell-based therapies are promising in regenerative medicine. However, the success of cell therapy is greatly limited by the low engraftment rate to the target tissues. The present study demonstrated that human mesenchymal stem cells (hMSCs) were subjected to a self selection process via microencapsulation in collagen barrier when they were induced to migrate out from this barrier. While retaining the immuophenotype and self renewal capacity, the selected hMSCs showed a significantly better in vitro migratory response of than those cultured in traditional monolayer. The migratory response could be controlled by varying the fabrication parameters of the collagen barrier, including initial collagen concentration and cells seeding density. Affinity to adhere on endothelial cells layer is another engraftment related property. Significant difference was observed between these selected hMSCs and hMSCs in monolayer culture. In order to investigate the engraftment potential of the selected hMSCs, an animal model was performed. The selected hMSCs were transplanted intravenously into NOD/SCID mice under partial hepatectomy. Presence of human cells in the residual liver was determined by the presence of human HLA-ABC using flow cytometry after 48 hours, 1 week and 1 month. Engraftment of the selected hMSCs was significantly higher than that of monolayer cultured hMSCs in time point of 1 month. It demonstrated that the selected hMSCs favor the engraftment to the injured liver. Further investigation is required to determine the fate of the engrafted hMSCs in order to truly confirm their therapeutic potential. The current work demonstrated that collagen-hMSCs microsphere could act as a barrier to select hMSCs with enhanced in vitro migratory response and in vivo engraftment properties. These findings may contribute towards the development of better stem cell therapies.
published_or_final_version
Mechanical Engineering
Master
Master of Philosophy

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15

Tsang, K. "Prioritization preferences for corneal transplantation allocation in Hong Kong". Click to view the E-thesis via HKUTO, 2004. http://sunzi.lib.hku.hk/hkuto/record/B31972226.

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Pawlowski, Kai. "Die strafrechtliche Bewertung der Organtransplantation /". Bochum : [s.n.], 2007. http://swbplus.bsz-bw.de/bsz267327285inh.pdf.

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Plata-Muñoz, Juan José. "Clinical, biochemical and molecular markers of injury before transplantation". Thesis, University of Oxford, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.572681.

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The use of organs from donors after circulatory death (DCD) has been recommended as one strategy to enlarge the donor pool and raise the transplant rate. However, DCD allografts had higher incidence of early post-transplant dysfunction. The general aim of this research project was to develop clinical and experimental strategies to reduce the incidence of early post-transplant dysfunction of kidney and liver allografts from DCD. First the ability of a clinical scoring system based on donor data for identifying DCD kidneys with high-risk of post-transplant dysfunction was evaluated using the Oxford and the UK National DCD kidney transplant cohorts. This works suggest that stratification of DCD kidneys before transplantation might allow early identification of kidneys in which lower graft function and survival could be expected if any additional therapeutic intervention is implemented. Second, as it has been suggested that hypothermic machine perfusion (HMP) may protect DCD kidneys from additional preservation injury and improve their outcome after transplantation, this work explored the benefit of HMP as preservation technique fo DCD kidneys in Oxford and discusses the potential of this technique for reducing the incidence of post-transplant dysfunction in DCD kidneys. The Oxford. Liver Group has provided evidence of the benefit of preservation with normothermic machine perfusion (NMP) on post-transplant function and survival of DCD liver allografts. In this work, the molecular mechanisms associated with this benefit were characterized using micro array technology. This analysis suggests that the beneficial effect ofNMP may be associated with the induction of the ischaemic preconditioning phenomenon and highlights a group of genes with potential for gene therapy. Finally, this works provides the "proof-of-concept" that the use of a non-mammalian viral vector for gene transfer of kidneys and livers during conventional cold preservation is feasible and is not associated with additional tissue injury.

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Dare, Anna Jane. "Targeting mitochondria during ischaemia-reperfusion injury in organ transplantation". Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708069.

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Poliachik, Sandra Louise. "Transplant organ preservation cooler". Thesis, Virginia Tech, 1991. http://hdl.handle.net/10919/41591.

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A method for preserving transplant organs for extended periods of time has been developed in the transplant organ preservation cooler. The preservation cooler enhances organ viability by maintaining a temperature controlled organ bath and pumping perfusate through the transplant organ. The emphasis on the transplant organ preservation cooler is to provide a simple and portable system which will be powered by boiled off oxygen from a liquid oxygen source. The design of the preservation cooler pump and temperature control system are presented. Results of tests proving the successful operation of the preservation cooler prototype are also presented.
Master of Science

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20

Cabaniss, Thomas Ervin. "The pastor's ministry to people facing organ transplantation". Online full text .pdf document, available to Fuller patrons only, 2001. http://www.tren.com.

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21

McGregor, Lesley M. "An investigation into the functional and psychosocial impact of living organ donation". Thesis, University of Stirling, 2010. http://hdl.handle.net/1893/2338.

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General Abstract Objective: In April 2006, the Scottish Liver Transplant Unit (SLTU) became the first NHS transplant unit in the UK to offer the option of Living Donor Liver Transplantation (LDLT). This represented a unique opportunity to evaluate the functional and psychosocial impact of LDLT upon healthy donors and their recipients. Subsequent aims were to investigate the challenge of introducing LDLT in Scotland and to establish the perceived deterrents and attractions of the procedure. An additional aim was to evaluate the impact of Living Donor Kidney Transplantation (LDKT) upon donors and recipients. Design: A series of cross sectional and longitudinal studies were designed for the purpose of this thesis (3 quantitative, 2 qualitative, and 1 mixed methods). Method: Self report questionnaires were used in each of the quantitative studies, with the addition of neuropsychological computerized tests in two studies. Semi-structured interviews were employed in the qualitative studies. Main Findings: •Prior to its introduction general support for the option of LDLT was found, although it was highlighted that the risk involved was not well understood by the general public. •Since becoming available LDLT has not been a readily acceptable treatment option from the perspective of patients due to the perceived risk for the donor, but it may be considered as a “last option”. Family members were motivated to save their loved one’s life but the personal implications of donating resulted in reconsideration of LDLT. • Staff at the SLTU perceived a lack of family commitment in relation to LDLT, which is explained as a cultural factor contributing to the slow uptake of LDLT. In Scotland, a donation from a younger to an older generation is not easily accepted. This, in addition to patients’ optimism that a deceased donation will arrive, and the poor health of potential donors, is thought to have affected the uptake of LDLT. As has the unit’s conservative approach to the promotion of LDLT. This approach is the result of a perceived reduction in the need for LDLT and a preference to avoid the risk to a healthy donor and conduct transplants with deceased donations. • In over 3 years, only one couple completed LDLT. The recipient showed functional and psychosocial improvement from pre to post procedure, whilst the donor showed slight deterioration in aspects of quality of life 6 weeks post donation, which did not always completely return to a baseline level by 6 months. The donor made sacrifices to provide her husband with a fresh start to life and unmet expectations were found to effect quality of life. •Willingness to become a liver donor is not thought to be influenced by the frame of the information provided. •Like the LDLT donor, LDKT donors experience some functional and psychosocial deterioration at 6 weeks post donation, but donors largely recover by 6 months post donation. However, the anticipated benefit to recipients was not evident and may not be quantifiable until after 6 months post operation. Conclusion: This thesis has added to current knowledge on living organ donation and specifically represents the first psychological evaluation of a UK LDLT programme. The slow uptake of LDLT was unexpected and has resulted in informative, novel research.

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Akhtar, Mohammed Zeeshan. "Improving the outcomes of kidney transplantation from deceased organ donors". Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:cd7c49f5-e5ce-415b-bdcb-7b59197bc1d0.

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This thesis sought to improve our understanding of how kidneys become injured as a consequence of organ donation, with the aim of improving the outcomes of transplantation. Every year, hundreds of patients on the waiting list die whilst awaiting a kidney transplant. With an ever-increasing demand for suitable organs, supply cannot keep up with the pressures on the transplant waiting list. As a consequence the transplant community are forced to use organs that previously would not have been considered suitable for transplant, including from older donors with additional comorbidities. This thesis aimed to develop an understanding as to how the kidney becomes injured during the donation process, identifying which key cellular homeostatic processes are disturbed as a consequence of donation. The thesis outlines the experimental development of rodent models of organ donation replicating the donation process for donation after brain death (DBD) and donation after circulatory death (DCD) donors and also the development of a kidney ischaemia reperfusion injury (IRI) model. Proteomics was subsequently used to identifying global protein alterations in the kidney as a consequence of brain death and ischemia reperfusion injury using bioinformatics tools to identify involvement of cellular pathways. The results indicated alterations in mitochondrial function and metabolic homeostasis occurring following brain death. Alterations in cellular metabolism and mitochondrial function were then confirmed using metabolomics and mitochondrial functional assays. I subsequently evaluated how alterations in cellular hypoxia and the hypoxia inducible factor system is altered in the brain dead organ donor kidney and aimed to target this system as a means of conditioning the brain dead organ donor to prevent mitochondrial and metabolic mediated injury to kidney cells following brain death. This involved exploring the role of prolyl hydroxylase inhibitors, including dimethyloxalylglycine, on mitochondrial function and whether this could be a therapeutic target in organ donation. This thesis provides important insights into the mechanism of injury of kidneys following brain death, providing evidence that even before procurement and preservation in the DBD donor alterations in mitochondrial function and metabolic homeostasis occur. I provide preliminary data on the use of prolyl hydroxylase inhibitors in altering mitochondrial function. I also outline my involvement in other ongoing projects in organ donation and machine perfusion that also aim to improve the outcomes of deceased donor kidney and liver transplantation.

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23

Heys, Stephen D. "The potentiation and alleviation of cyclosporin A nephrotoxicity in the Lewis rat". Thesis, University of Aberdeen, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.254668.

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Cyclosporin A immunosuppression following organ transplantation is associated with a reversible nephrotoxicity as manifested by elevations in serum urea and creatinine concentrations and urinary N-acetyl-B-D-glucosaminidase activities. The metabolism of Cyclosporin A is primarily via the hepatic cytochrome P-450 mono-oxygenase system with previous studies having demonstrated that the short term co-administration of phenobarbitone, an inducer of this enzyme system, ameliorates this nephrotoxicity in the non-renal allografted rat. Initial studies demonstrated that the induction of Cyclosporin A nephrotoxicity in the Lewis rat followed by the co-administration of phenobarbitone in the long term abolished nephrotoxicity in the female whilst alleviating it in the male animal. In addition Cyclosporin A hepatotoxicity was also abolished in female rats co-treated with phenobarbitone. A rat renal transplantation model was successfully developed to allow the study of Cyclosporin A nephrotoxicity in the renal allografted animal. Initial studies demonstrated a protective effect of phenobarbitone against Cyclosporin A nephrotoxicity within the first 14 days of treatment in female, but not male allografted animals. These studies also demonstrated a greater susceptibility of the male renal allografted and surgically intact rat to Cyclosporin A induced nephrotoxicity. The effect of ischaemia and sympathetic nervous system denervation were investigated using a series of Lewis syngeneic renal transplanted animals. Histological examination revealed Cyclosporin A induced renal damage to be more marked in non-transplanted than transplanted kidneys. The results are discussed in relation to cold and warm ischaemia and also to the role of the sympathetic nervous and renin-angiotensin-aldosterone systems in the potentiation of Cyclosporin A induced nephrotoxicity. The effect of long term phenobarbitone treatment on Cyclosporin A induced deteriorations in renal and hepatic function was determined using the Lewis syngeneic transplant model. The effect of intraoperative liver ischaemia and diethyl ether anaesthesia on hepatic function and their potentiation of Cyclosporin A hepatotoxicity is also considered. Finally the role of surgical stress and reduction of renal mass by unilateral nephrectomy, on Cyclosporin A nephrotoxicity was studied revealing a protective effect of unilateral nephrectomy against nephrotoxicity in the female animal. Previous studies have demonstrated that reduction in renal mass results in glomerulosclerosis with a progressive impairment of renal function. The protective effect of unilateral nephrectomy reported here is discussed in relation to a Cyclosporin A induced reduction in glomerular filtration rate and subsequent protection against glomerulosclerosis.

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Higginbotham, Bradley Y. Beard T. Randolph. "An examination of the impact of the Organ Donation Breakthrough Collaborative on kidney transplant activity". Auburn, Ala, 2009. http://hdl.handle.net/10415/1738.

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Greenwood, Gay. "The spaces within : a Foucaudian analysis of organ donation discourses /". Title page, table of contents and abstract only, 1999. http://web4.library.adelaide.edu.au/theses/09PH/09phg81652.pdf.

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Weston, Lyanne. "An investigation of relationships between cytokine-secreting T lymphocytes and transplantation outcome". Thesis, The University of Sydney, 2002. https://hdl.handle.net/2123/27850.

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A major limitation to the success of transplantation is the immune interaction of the recipient and the graft tissue. When considering solid organ transplantation the major obstacle is overcoming rejection by the recipient of the foreign graft. For bone marrow transplantation it is the response of the immunologically viable donor cells to the immunocompromised recipient resulting in the development of Graft—versus-Host Disease. T cells play a crucial role in the immune response in transplantation by dictating allograft rejection and acceptance. Recognition of (or by) transplanted cells as self or foreign is determined by the highly polymorphic genes of the MHC locus. Although rejection may be prevented or treated by immunosuppressive drug therapy, minimising the immunogenicity of the graft by limiting MHC differences is preferable. When considering solid organ transplantation however, matching for MHC parity is rarely practicable. In Bone marrow transplantation parity at MHC is highly recommended. Matching by molecular and cellular techniques, use of siblings, and depletion of T cells from the inoculum are all techniques currently used to minimise alloreactivity. Despite matching at the MHC there are donor-recipient pairs for whom success eludes after bone marrow transplantation. Given the current capability to identify and characterise the MHC alleles of all potential bone marrow transplant pairs using molecular typing, it is thought that this reaction is directed against minor histocompatibility antigens.

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Waring, Duff William Ramus. "Medical benefit and the human lottery an egalitarian approach to patient selection /". Dordrecht ; Norwell, Mass. : Springer, 2004. http://site.ebrary.com/id/10221758.

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Staatz, Christine Elizabeth. "Population pharmacokinetics of tacrolimus with pharmacodynamic exploration in different organ transplant groups /". St. Lucia, Qld, 2001. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe16521.pdf.

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Tziampazis, Evangelos. "Engineering functional, insulin-secreting cell systems : effect of entrapment on cellular environment and secretory response". Thesis, Georgia Institute of Technology, 1993. http://hdl.handle.net/1853/10026.

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Bester, Dreyer. "A study of the effects of warm ischaemic times on harvested homografts". Thesis, Bloemfontein : Central University of Technology, Free State, 2009. http://hdl.handle.net/11462/48.

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Wong, Hoi-ling, i 王凱玲. "Migration and other characteristics of collagen microencapsulated hMSCs: a comparison with hMSCs intraditional 2D culture". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B4150902X.

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32

Summers, Dominic Mark. "Maximising the potential for kidney donation in the UK : the role of donation after circulatory-death". Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.645969.

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Wong, Hoi-ling. "Migration and other characteristics of collagen microencapsulated hMSCs a comparison with hMSCs in traditional 2D culture /". Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B4150902X.

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Li, Xianliang, i 李先亮. "Insulin in UW solution exacerbates the ischemia/reperfusion injury in rat liver transplantation". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B27785257.

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Moalimishak, Mohamed Rashad. "[The] ethical evaluation of brain dead persons and organ transplantation in contemporary Muslim ethics". Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=105427.

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This dissertation is primarily about the ethical evaluation ofbrain death, brain-dead persons and organ transplantation in contemporary Muslim ethics.
Cette tQese est premierement au sujet de l'évaluation éthique de la mort cérébrale et les personnes dans un coma dépassé aux éthiques Musulmanes contemporaines.

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Dansirikul, Chantaratsamon. "Pharmacokinetic studies with sirolimus and tacrolimus /". [St. Lucia, Qld.], 2004. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe18266.pdf.

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楊振帆 i Zhenfan Yang. "Recombinant adeno-associated virus vector as a novel vehicle organ transplantation and long-term allograft survival induced by rAAV-hCTLA4Ig gene transfer combined with low-dose FK506". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B31243861.

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Kozak, Allyson Jill. "The balance of nitric oxide and peroxynitrite in the heart during organ preservation". View abstract, 2007. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:3295438.

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Yang, Zhenfan. "Recombinant adeno-associated virus vector as a novel vehicle organ transplantation and long-term allograft survival induced by rAAV-hCTLA4Ig gene transfer combined with low-dose FK506 /". Hong Kong : University of Hong Kong, 2002. http://sunzi.lib.hku.hk/hkuto/record.jsp?B25085530.

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Tsang, K., i 曾光. "Prioritization preferences for corneal transplantation allocation in Hong Kong". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B31972226.

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41

Campbell, Kenneth. "Internal organization and functional regulation of intrastriatal striatal transplants a study using in situ hybridization histochemistry and intracerebral microdialysis in the excitotoxically lesioned and grafted rat striatum /". Lund : Department of Medical Cell Research, Lund University, 1994. http://books.google.com/books?id=j-tqAAAAMAAJ.

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42

Lexis, Louise A. "Cyclosporine A induced alterations to endothelial function and erythrocyte and plasma redox balande, and the benefits of antioxidant supplementation /". [St. Lucia, Qld.], 2005. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe18605.pdf.

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43

Brown, Kennard D. "An analysis of the differences in preemptive kidney transplantation between blacks and whites". View the abstract Download the full-text PDF version, 2008. http://etd.utmem.edu/ABSTRACTS/2008-006-Brown-Index.html.

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Thesis (Ph.D. )--University of Tennessee Health Science Center, 2008.
Title from title page screen (viewed on April 24, 2008 ). Research advisor: Shelly White-Means, Ph.D. Document formatted into pages (xi, 101 p. : ill.). Vita. Abstract. Includes bibliographical references (p. 94-100).

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Dugan, Aisling Siobhan. "The interactions between BK virus and host cell receptors". View abstract/electronic edition; access limited to Brown University users, 2008. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3318311.

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Moraes, Edvaldo Leal de. "Vivência de enfermeiros no processo de doação órgãos e tecidos para transplante". Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/7/7140/tde-10092013-184153/.

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Introdução: a escassez de órgãos e tecidos continua sendo um dos maiores obstáculos para as equipes de transplantes em todos os países. Diante desse cenário, ressalta-se a importância do trabalho realizado pelos enfermeiros na viabilização de órgãos e tecidos para transplante. Objetivo: esta pesquisa teve como objetivo compreender o significado da ação de enfermeiros no processo de doação para viabilizar órgãos e tecidos para transplante. Método: optou-se por realizar uma pesquisa qualitativa, com a abordagem da fenomenologia social de Alfred Schutz. Os dados foram coletados entre setembro de 2011 e junho de 2012, por meio de entrevistas com as seguintes questões norteadoras: você poderia me contar sua experiência no processo de doação de órgãos e tecidos para transplante? O que você espera com sua atuação nesse processo? Como você considera que deve ser esse processo? Participaram do estudo dez enfermeiros com diferentes tempos de formação e atuação de três Serviços de Procura de Órgãos e Tecidos da cidade de São Paulo. Após a obtenção dos discursos, estes foram analisados individualmente, seguindo procedimentos organizados de modo sistemático, preconizados por pesquisadores da Fenomenologia Social. Resultados: o contexto do significado da ação dos enfermeiros no processo de doação foi desvelado, tendo como base a vivência desses profissionais nesse cenário, representado pelas categorias: obstáculos vivenciados, intervenções realizadas e contribuição do trabalho. A intencionalidade da ação para viabilizar órgãos e tecidos para transplante está descrita pelas categorias: mudar paradigmas, humanizar o processo de doação, ser reconhecido, aumentar a doação e salvar vidas. Para os enfermeiros participantes do estudo, o processo de doação é marcado por obstáculos nas diversas etapas e frente a essas dificuldades realizam intervenções para aperfeiçoar esse campo da saúde, reconhecendo a importância do trabalho no âmbito pessoal, profissional e social. Ao refletirem sobre seus atos, os enfermeiros percebem que seu papel como agentes de transformação é essencial, e as ações são projetadas com o intuito de mudar os paradigmas da equipe multidisciplinar, e a educação é utilizada, como um instrumento relevante na promoção de um novo modo de ver e pensar essa especialidade da área da saúde. Diante da possibilidade de mudança de atitude, esses atores sociais vislumbram a oportunidade de humanizar a assistência oferecida aos familiares do doador falecido e esperam ser reconhecidos como interlocutores, articuladores e facilitadores no processo de doação e transplante, intencionando com suas ações aumentar a doação e, com isso, salvar vidas. Considerações finais: o que se mostrou como típico na ação social dos enfermeiros, com base nos dados obtidos da vivência desses sujeitos, indicou caminhos para superar as barreiras no processo de doação e para a realização de futuras pesquisas, que possibilitarão a construção do conhecimento nesse campo da enfermagem.
Introduction: the shortage of organs and tissues remains a major obstacles for transplant teams in all countries. Given this scenario, it emphasizes the work done by nurses in the viability of organs and tissues for transplantation. Objective: this research aimed to understand the significance of the nurses actions in the donation process for procuring organs and tissues for transplantation. Method: a qualitative research approach, with the social phenomenology of Alfred Schutz, was selected. Data was collected from September 2011 to June 2012, through interviews containing the following questions: could you tell me your experience in the process of donating organs and tissues for transplantation? What do you expect in your performance in this process? How do you think this process should be? Ten nurses participated in this study from different graduation timeframes and working at three Services for Procurement of Organs and Tissues in the city of São Paulo. After obtaining the statements, each was individually analyzed, following procedures systematically organized, and advocated by researchers of Social Phenomenology. Results: The context of the significance of the nurses actions in the donation process was revealed, based on the experience of these professionals, in this scenario, represented in categories: obstacles experienced, interventions and labor contribution. The intentionality of actions to procure organs and tissues for transplantation is described through the following categories: changing paradigms, humanizing the donation process, recognition, increasing donations and saving lives. For nurses participating in this study, the donation processes is marked by obstacles in the various stages and in order to face these difficulties, perform interventions to improve this field of health, recognizing the importance of their work in a personal, professional and social context. When reflecting on their actions, nurses perceive their role as agents of change and essential and therefore actions are designed to change the paradigms of the multidisciplinary team, and that education should be used as an important tool in promoting a new way of seeing and thinking for this healthcare specialty. Facing the possibility of attitude changes, these social actors envision an opportunity to humanize the assistance offered to the families of the deceased donor and expect to be recognized as speakers, organizers and facilitators in the process of donation and transplantation with the intention, through these actions, to establish a new way of increasing donations and thereby saving lives. Final Considerations: What proved to be typical in the social action of these nurses, derived from the data obtained about their experiences with this subject, indicated ways to overcome barriers in the donation process as well as indicated a necessity to conduct further research, to aid in the construction of a knowledge base in this particular field of nursing

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Chan, Chun-wai, i 陳春慧. "In-vitro study of the cryopreserved intervertebral disc". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B41290380.

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Filion, Potts Tera M. "Biomimetic Synthetic Tissue Scaffolds for Bone Regeneration: A Dissertation". eScholarship@UMMS, 2011. https://escholarship.umassmed.edu/gsbs_diss/556.

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Injury to bone is one of the most prevalent and costly medical conditions. Clinical treatment of volumetric bone loss or hard-to-heal bony lesions often requires the use of proper bone grafting materials, with or without adjuvant anabolic therapeutics. Despite significant problems associated with autografting (donor site morbidity, limited supplies) and allografting (disease transmissions, high graft failure rates) procedures, synthetic bone grafts remain the least utilized clinically. Existing synthetic orthopaedic biomaterials rarely possess a combination of bone-like structural and biochemical properties required for robust osteointegration, scalable and user-friendly characteristics indispensable for successful clinical translations. This thesis tests the hypothesis that by recapitulating key structural elements and biochemical components of bone in 3- and 2-dimensional biomaterials, scalable synthetic bone grafts can be designed to enable expedited healing of hard-to-heal volumetric bone loss. Specifically, FlexBone, a 3-dimensional hydrogel scaffold encapsulating 50 wt% of structurally well integrated nanocrylstalline hydroxyapatite, the main inorganic component of bone, was developed. The large surface area of nanocrystalline hydroxyapatite combined with its intrinsic affinity to proteins and its excellent structural integration with the hydrogel matrix enabled FlexBone to both sequester endogenous protein signals upon press-fitting into an area of skeletal defect and to deliver exogenous protein therapeutics in a localized and sustained manner. We demonstrated that FlexBone enabled the functional healing of critical-size long bone defects in rats in 8 – 12 weeks with the addition of a very low dose of osteogenic growth factor BMP-2/7. This promising synthetic bone graft is now being explored for the delivery of multiple growth factors to expedite the healing of diabetic bony lesions. In addition, a 2-dimensional electrospun cellulose fibrous mesh was chemically modified with sulfate residues to mimic sulfated polysaccharide ECM components of skeletal tissues to enabled progenitor cell attachment and differentiation as well as controlled retention and localized/sustained delivery of protein therapeutics. This sulfated fibrous mesh is currently explored as synthetic periosteum to augment the osteointegration of devitalized structural allografts. Finally, a rat subcutaneous implantation model developed to examine the biocompatibility of newly developed biodegradable shape memory polymer bone substitutes is also presented.

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Cohen, Elizabeth Leigh. ""My Loss is Your Gain": Examining the Role of Message Frame, Perceived Risk, and Ambivalence in the Decision to Become an Organ Donor". unrestricted, 2007. http://etd.gsu.edu/theses/available/etd-08062007-011153/.

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Thesis (M.A.)--Georgia State University, 2007.
Title from file title page. Cynthia Hoffner, committee chair; Yuki Fujioka, Holley Wilkin, committee members. Electronic text ( 81 p.) : digital, PDF file. Description based on contents viewed Nov. 8, 2007. Includes bibliographical references (p. 57-65).

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Talbert, Robert John. "Photoacoustic discrimination of viable and thermally coagulated blood for burn injury imaging". Diss., Columbia, Mo. : University of Missouri-Columbia, 2007. http://hdl.handle.net/10355/5081.

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Thesis (M.S.)--University of Missouri-Columbia, 2007.
The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file (viewed on January 11, 2008) Includes bibliographical references.

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Moraes, Bianca Nascimento. "Perfil, crenças, sentimentos e atitudes de familiares doadores e não-doadores de órgãos". Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/5/5131/tde-28082009-102356/.

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A escassez de órgãos para transplante representa um problema mundial. No Brasil, apenas um sexto dos potenciais doadores que chegam às Unidades de Terapia Intensiva tornam-se doadores efetivos. A negativa das famílias representa o principal obstáculo para o processo de doação e transplante de órgãos. OBJETIVOS: Explorar os fatores associados com a decisão de doar entre as famílias de potenciais doadores de órgãos sólidos e correlacioná-los com a taxa de consentimento. MÉTODOS: No período de novembro de 2004 a maio de 2006, 243 famílias de potenciais doadores foram entrevistadas pela Organização de Procura de Órgãos do Hospital das Clínicas para se manifestarem quanto à possibilidade de doação de órgãos. Após um ano do óbito, respeitando-se o luto, todas as famílias foram convocadas para uma nova entrevista, objeto do presente estudo. Para tanto, utilizou-se um questionário fechado com entrevista devidamente estruturada. Os dados coletados foram analisados quantitativamente. Todas as análises estatísticas foram realizadas com auxílio do programa SPSS para Windows 13.0. Significância estatística foi assumida para o valor de p < 0,05. RESULTADOS: Dos 56 familiares que concordaram em participar do projeto, 57% haviam concordado com a doação e 43% recusado. Entre outros fatores, gênero, etnia, escolaridade, renda e religião não influenciaram no processo de doação. Diferentes variáveis foram associadas à decisão de doar na análise bivariada, por exemplo: idade mais avançada do potencial doador (p=0,007), morte encefálica causada por doença (p=0,004), satisfação familiar com o profissionalismo da abordagem para doação (p=0,004), crenças funcionais como fazer o bem antecedentes à decisão (p=0,001), sentimento de conforto durante a abordagem da Organização de Procura de Órgãos (0,027), e opinião e atitude de maior peso no processo decisório foram dos descendentes ou colaterais do potencial doador (p=0,005). Porém na análise multivariada somente idade do potencial doador e opinião de maior peso no processo decisório emergiram como variáveis significativas correlacionadas positivamente com o consentimento da doação. CONCLUSÕES: Quando irmãos, tios ou filhos do potencial doador estão diretamente envolvidos no processo de tomada de decisão, normalmente o potencial doador tem idade mais avançada e a probabilidade de consentir a doação é estatisticamente maior. Aspectos que dificultam a aceitação da perda como: morte violenta; estreito vínculo afetivo; idade prematura; inversão da ordem natural, isto é, filho morrer antes dos pais; e principalmente negação da morte são fatores que também dificultam o consentimento para a doação de órgãos. Estratégias no campo da captação de órgãos devem ser aprimoradas e desenvolvidas visando uma abordagem cada vez mais humana e educativa para os coordenadores e membros das Organizações de Procura de Órgãos.
Organs transplant shortage is a global problem. In Brazil, only a sixth of potential donors who come to the Intensive Care Units become effective donors. The main obstacle to the organs donation and transplantation process is the refuse of families. OBJETIVES: to determine the donors profile, in order to understand which are the most determinant features related to positive or refuses donation decisions. METHODS: From November 2004 to May 2006, Organ Procurement Organization (OPO) approached 243 next-of-kin of brain-dead patients to ask about the organs donation from these potential donors. After a year, in respect for their mourning, all families were summoned to a new interview, object of this study. However, to assess the donors profile, a structured interview was used. The data was analyzed quantitatively. All statistical analysis was performed with the SPSS software for Windows 13.0. Statistical Significance was assumed for the p < 0.05. RESULTS: 56 relatives (57% donors and 43% non-donors) participated in the study. This research observed that gender, ethnicity, education, income and religion did not influence the donation process. Different variables were associated with the donation decision in bivariate analysis, for example, older age of the potential donor (p=0,007), brain death caused by disease (p=0,004), family satisfaction with the professionalism of the approach to donation (p=0,004), functional beliefs as I must do well record the decision (p=0,001), feeling of comfort during the OPO approached (0,027) and relevant opinion and attitude in decision-making was collateral relative (sibling/uncle) or a son of the potential donor (p=0,005). Otherwise in multivariate analysis only the potential donor age and relevant opinion in decision-making emerged as positive significant variable correlated with the consent of the donation. CONCLUSIONS: When brothers, uncles or son of potential donors are involved directly in decision-making process, the potential donor is always older and the probability to consent donation is statistically higher. Aspects that make difficult to accept the loss as a violent death, strong emotional bond, early age, reversing natural order, like when a son die before their parents, and especially denial of death are factors that difficult the consent for organs donation. Strategies in the field of donation should be developed, aiming to improve human and educational levels for coordinators and members of OPO.

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