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Artykuły w czasopismach na temat „Transcriptional co-activator with PDZ-Binding motif (TAZ)”

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Data publikacji: 5 kwietnia 2025

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1

Wu, Chia-Lin, Chia-Chu Chang, Tao-Hsiang Yang, et al. "Tubular transcriptional co-activator with PDZ-binding motif protects against ischemic acute kidney injury." Clinical Science 134, no. 13 (2020): 1593–612. http://dx.doi.org/10.1042/cs20200223.

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Abstract Transcriptional co-activator with PDZ-binding motif (TAZ) is a key downstream effector of the Hippo tumor-suppressor pathway. The functions of TAZ in the kidney, especially in tubular epithelial cells, are not well-known. To elucidate the adaptive expression, protective effects on kidney injury, and signaling pathways of TAZ in response to acute kidney injury (AKI), we used in vitro (hypoxia-treated human renal proximal tubular epithelial cells [RPTECs]) and in vivo (mouse ischemia–reperfusion injury [IRI]) models of ischemic AKI. After ischemic AKI, TAZ was up-regulated in RPTECs and

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Huang, Yao, Xueqian Ouyang, Jinghua Tan, Zhenyu Meng, Xiuwen Ma, and Yiguo Yan. "The physiological and pathogenic roles of yes-associated protein/transcriptional co-activator with PDZ-binding motif in bone or skeletal motor system-related cells." Cytojournal 22 (February 8, 2025): 13. https://doi.org/10.25259/cytojournal_237_2024.

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Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) are the primary downstream effectors of the Hippo signaling pathway. This pathway plays a crucial role in regulating organ size, maintaining tissue homeostasis, and controlling cellular processes such as fate determination and tissue development. This review provides an overview of the current understanding of how the transcriptional regulators YAP and TAZ contribute to the physiological and pathological processes in tissues and cells associated with the skeletal motor system. The underlying molecular me

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Liu, Tao, Jiaojiao Zhou, Yanmin Chen, et al. "Genome-Wide Characterization of TAZ Binding Sites in Mammary Epithelial Cells." Cancers 15, no. 19 (2023): 4713. http://dx.doi.org/10.3390/cancers15194713.

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The transcriptional co-activator with PDZ binding motif (TAZ) is a key effector of the Hippo signaling pathway. We and others previously reported that high expression levels of TAZ are positively associated with decreased survival rates and shorter times to relapse in basal-like breast cancer (BLBC) patients. The oncogenic activity of TAZ involves the regulation of diverse signal transduction pathways that direct processes such as cell proliferation, migration, and resistance to apoptosis, albeit through poorly characterized gene expression programs. Here, using a tet-inducible system in mamma

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Salem and Hansen. "The Hippo Pathway in Prostate Cancer." Cells 8, no. 4 (2019): 370. http://dx.doi.org/10.3390/cells8040370.

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Despite recent efforts, prostate cancer (PCa) remains one of the most common cancers in men. Currently, there is no effective treatment for castration-resistant prostate cancer (CRPC). There is, therefore, an urgent need to identify new therapeutic targets. The Hippo pathway and its downstream effectors—the transcriptional co-activators, Yes-associated protein (YAP) and its paralog, transcriptional co-activator with PDZ-binding motif (TAZ)—are foremost regulators of stem cells and cancer biology. Defective Hippo pathway signaling and YAP/TAZ hyperactivation are common across various cancers. H

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Tiffon, Camille, Julie Giraud, Silvia Elena Molina-Castro, et al. "TAZ Controls Helicobacter pylori-Induced Epithelial–Mesenchymal Transition and Cancer Stem Cell-Like Invasive and Tumorigenic Properties." Cells 9, no. 6 (2020): 1462. http://dx.doi.org/10.3390/cells9061462.

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Helicobacter pylori infection, the main risk factor for gastric cancer (GC), leads to an epithelial–mesenchymal transition (EMT) of gastric epithelium contributing to gastric cancer stem cell (CSC) emergence. The Hippo pathway effectors yes-associated protein (YAP) and transcriptional co-activator with PDZ binding motif (TAZ) control cancer initiation and progression in many cancers including GC. Here, we investigated the role of TAZ in the early steps of H. pylori-mediated gastric carcinogenesis. TAZ implication in EMT, invasion, and CSC-related tumorigenic properties were evaluated in three

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MAHONEY, William M., Jeong-Ho HONG, Michael B. YAFFE, and Iain K. G. FARRANCE. "The transcriptional co-activator TAZ interacts differentially with transcriptional enhancer factor-1 (TEF-1) family members." Biochemical Journal 388, no. 1 (2005): 217–25. http://dx.doi.org/10.1042/bj20041434.

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Members of the highly related TEF-1 (transcriptional enhancer factor-1) family (also known as TEAD, for TEF-1, TEC1, ABAA domain) bind to MCAT (muscle C, A and T sites) and A/T-rich sites in promoters active in cardiac, skeletal and smooth muscle, placenta, and neural crest. TEF-1 activity is regulated by interactions with transcriptional co-factors [p160, TONDU (Vgl-1, Vestigial-like protein-1), Vgl-2 and YAP65 (Yes-associated protein 65 kDa)]. The strong transcriptional co-activator YAP65 interacts with all TEF-1 family members, and, since YAP65 is related to TAZ (transcriptional co-activato

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Chu, Cong-Qiu, and Taihao Quan. "Fibroblast Yap/Taz Signaling in Extracellular Matrix Homeostasis and Tissue Fibrosis." Journal of Clinical Medicine 13, no. 12 (2024): 3358. http://dx.doi.org/10.3390/jcm13123358.

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Tissue fibrosis represents a complex pathological condition characterized by the excessive accumulation of collagenous extracellular matrix (ECM) components, resulting in impaired organ function. Fibroblasts are central to the fibrotic process and crucially involved in producing and depositing collagen-rich ECM. Apart from their primary function in ECM synthesis, fibroblasts engage in diverse activities such as inflammation and shaping the tissue microenvironment, which significantly influence cellular and tissue functions. This review explores the role of Yes-associated protein (Yap) and Tran

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8

Warren, Janine, Yuxuan Xiao, and John Lamar. "YAP/TAZ Activation as a Target for Treating Metastatic Cancer." Cancers 10, no. 4 (2018): 115. http://dx.doi.org/10.3390/cancers10040115.

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Yes-Associated Protein (YAP) and Transcriptional Co-activator with PDZ-binding Motif (TAZ) have both emerged as important drivers of cancer progression and metastasis. YAP and TAZ are often upregulated or nuclear localized in aggressive human cancers. There is abundant experimental evidence demonstrating that YAP or TAZ activation promotes cancer formation, tumor progression, and metastasis. In this review we summarize the evidence linking YAP/TAZ activation to metastasis, and discuss the roles of YAP and TAZ during each step of the metastatic cascade. Collectively, this evidence strongly sugg

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9

Park, Sangryong, Ho-Young Lee, Jayoung Kim, et al. "Cerebral Cavernous Malformation 1 Determines YAP/TAZ Signaling-Dependent Metastatic Hallmarks of Prostate Cancer Cells." Cancers 13, no. 5 (2021): 1125. http://dx.doi.org/10.3390/cancers13051125.

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Enhanced Yes-associated protein (YAP)/transcriptional co-activator with PDZ-binding motif (TAZ) signaling is correlated with the extraprostatic extension of prostate cancer. However, the mechanism by which YAP/TAZ signaling becomes hyperactive and drives prostate cancer progression is currently unclear. In this study, we revealed that higher expression of CCM1, which is uniquely found in advanced prostate cancer, is inversely correlated with metastasis-free and overall survival in patients with prostate cancer. We also demonstrated that CCM1 induces the metastasis of multiple types of prostate

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Lauriola, Angela, Elisa Uliassi, Matteo Santucci, et al. "Identification of a Quinone Derivative as a YAP/TEAD Activity Modulator from a Repurposing Library." Pharmaceutics 14, no. 2 (2022): 391. http://dx.doi.org/10.3390/pharmaceutics14020391.

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The transcriptional regulators YAP (Yes-associated protein) and TAZ (transcriptional co-activator with PDZ-binding motif) are the major downstream effectors in the Hippo pathway and are involved in cancer progression through modulation of the activity of TEAD (transcriptional enhanced associate domain) transcription factors. To exploit the advantages of drug repurposing in the search of new drugs, we developed a similar approach for the identification of new hits interfering with TEAD target gene expression. In our study, a 27-member in-house library was assembled, characterized, and screened

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Liu, Yuchen, Xiaohui Wang, and Yingzi Yang. "Hepatic Hippo signaling inhibits development of hepatocellular carcinoma." Clinical and Molecular Hepatology 26, no. 4 (2020): 742–50. http://dx.doi.org/10.3350/cmh.2020.0178.

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Primary liver cancer is one of the most common cancer worldwide. Hepatocellular carcinoma (HCC) in particular, is the second leading cause of cancer deaths in the world. The Hippo signaling pathway has emerged as a major oncosuppressive pathway that plays critical roles inhibiting hepatocyte proliferation, survival, and HCC formation. A key component of the Hippo pathway is the inhibition of yes-associated protein (YAP)/transcriptional co-activator with PDZ-binding motif (TAZ) transcription factors by the Hippo kinase cascade. Aberrant activation of YAP or TAZ has been found in several human c

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Chen, Guangyuan, Ping Huang, Jiabin Xie, and Rihong Li. "Overexpression of transcriptional co-activator with PDZ-binding motif promotes epithelial mesenchymal transformation of ovarian cancer cells by upregulating Smad3 and Snail1." Materials Express 10, no. 1 (2020): 120–26. http://dx.doi.org/10.1166/mex.2020.1617.

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This study is intended to explore the effect of transcriptional coactivator with PDZ binding motif (TAZ) expression in ovarian cancer cells as well as investigate the expression of signal proteins Smad3 and Snail1. Ovarian cancer cells (SKOV-3) were divided into two groups: control and TAZ overexpression. The overexpression of TAZ in SKOV-3 cells was determined by immunofluorescence, western blot, and qRT-PCR. The proliferation, invasiveness, and expression of epithelial mesenchymal transformation (EMT)-associated proteins were detected, and the expression of Smad3 and Snail1 proteins was dete

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13

Van Haele, Matthias, Iván Moya, Ruçhan Karaman, et al. "YAP and TAZ Heterogeneity in Primary Liver Cancer: An Analysis of Its Prognostic and Diagnostic Role." International Journal of Molecular Sciences 20, no. 3 (2019): 638. http://dx.doi.org/10.3390/ijms20030638.

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Primary liver cancer comprises a diverse group of liver tumors. The heterogeneity of these tumors is seen as one of the obstacles to finding an effective therapy. The Hippo pathway, with its downstream transcriptional co-activator Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ), has a decisive role in the carcinogenesis of primary liver cancer. Therefore, we examined the expression pattern of YAP and TAZ in 141 patients with hepatocellular carcinoma keratin 19 positive (HCC K19+), hepatocellular carcinoma keratin 19 negative (HCC K19−), combined hepat

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El Yousfi, Younes, Rocío Mora-Molina, Abelardo López-Rivas, and Rosario Yerbes. "Role of the YAP/TAZ-TEAD Transcriptional Complex in the Metabolic Control of TRAIL Sensitivity by the Mevalonate Pathway in Cancer Cells." Cells 12, no. 19 (2023): 2370. http://dx.doi.org/10.3390/cells12192370.

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Different studies have reported that inhibiting the mevalonate pathway with statins may increase the sensitivity of cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), although the signaling mechanism leading to this sensitization remains largely unknown. We investigated the role of the YAP (Yes-associated protein)/TAZ (transcriptional co-activator with PDZ-binding motif)-TEAD (TEA/ATTS domain) transcriptional complex in the metabolic control of TRAIL sensitivity by the mevalonate pathway. We show that depleting nuclear YAP/TAZ in tumor cells, either via treatment

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Thrash, Hannah L., and Ann Marie Pendergast. "Multi-Functional Regulation by YAP/TAZ Signaling Networks in Tumor Progression and Metastasis." Cancers 15, no. 19 (2023): 4701. http://dx.doi.org/10.3390/cancers15194701.

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The Hippo pathway transcriptional co-activators, YES-associated protein (YAP) and Transcriptional Co-Activator with PDZ Binding Motif (TAZ), have both been linked to tumor progression and metastasis. These two proteins possess overlapping and distinct functions, and their activities lead to the expression of genes involved in multiple cellular processes, including cell proliferation, survival, and migration. The dysregulation of YAP/TAZ-dependent cellular processes can result in altered tumor growth and metastasis. In addition to their well-documented roles in the regulation of cancer cell gro

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Zhang, Jinglin, Yuhang Zhou, Patrick Tang, et al. "Mechanotransduction and Cytoskeleton Remodeling Shaping YAP1 in Gastric Tumorigenesis." International Journal of Molecular Sciences 20, no. 7 (2019): 1576. http://dx.doi.org/10.3390/ijms20071576.

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The essential role of Hippo signaling pathway in cancer development has been elucidated by recent studies. In the gastrointestinal tissues, deregulation of the Hippo pathway is one of the most important driving events for tumorigenesis. It is widely known that Yes-associated protein 1 (YAP1) and WW domain that contain transcription regulator 1 (TAZ), two transcriptional co-activators with a PDZ-binding motif, function as critical effectors negatively regulated by the Hippo pathway. Previous studies indicate the involvement of YAP1/TAZ in mechanotransduction by crosstalking with the extracellul

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Tóth, Marcell, Shan Wan, Jennifer Schmitt, et al. "The Cell Polarity Protein MPP5/PALS1 Controls the Subcellular Localization of the Oncogenes YAP and TAZ in Liver Cancer." International Journal of Molecular Sciences 26, no. 2 (2025): 660. https://doi.org/10.3390/ijms26020660.

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The oncogenes yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) are potent liver oncogenes. Because gene mutations cannot fully explain their nuclear enrichment, we aim to understand which mechanisms cause YAP/TAZ activation in liver cancer cells. The combination of proteomics and functional screening identified numerous apical cell polarity complex proteins interacting with YAP and TAZ. Co-immunoprecipitation (Co-IP) experiments confirmed that membrane protein palmitoylated 5 (MPP5; synonym: PALS1) physically interacts with YAP and TAZ. After removing d

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Gandhirajan, Rajesh Kumar, Manaswita Jain, Benedikt Walla, et al. "CysteineS-Glutathionylation Promotes Stability and Activation of the Hippo Downstream Effector Transcriptional Co-activator with PDZ-binding Motif (TAZ)." Journal of Biological Chemistry 291, no. 22 (2016): 11596–607. http://dx.doi.org/10.1074/jbc.m115.712539.

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Di Benedetto, Giorgia, Silvia Parisi, Tommaso Russo, and Fabiana Passaro. "YAP and TAZ Mediators at the Crossroad between Metabolic and Cellular Reprogramming." Metabolites 11, no. 3 (2021): 154. http://dx.doi.org/10.3390/metabo11030154.

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Cell reprogramming can either refer to a direct conversion of a specialized cell into another or to a reversal of a somatic cell into an induced pluripotent stem cell (iPSC). It implies a peculiar modification of the epigenetic asset and gene regulatory networks needed for a new cell, to better fit the new phenotype of the incoming cell type. Cellular reprogramming also implies a metabolic rearrangement, similar to that observed upon tumorigenesis, with a transition from oxidative phosphorylation to aerobic glycolysis. The induction of a reprogramming process requires a nexus of signaling path

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Kim, Jongwan, Haiyan Jin, Jinhyuk Kim, et al. "Leveraging the Fragment Molecular Orbital and MM-GBSA Methods in Virtual Screening for the Discovery of Novel Non-Covalent Inhibitors Targeting the TEAD Lipid Binding Pocket." International Journal of Molecular Sciences 25, no. 10 (2024): 5358. http://dx.doi.org/10.3390/ijms25105358.

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The Hippo pathway controls organ size and homeostasis and is linked to numerous diseases, including cancer. The transcriptional enhanced associate domain (TEAD) family of transcription factors acts as a receptor for downstream effectors, namely yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ), which binds to various transcription factors and is essential for stimulated gene transcription. YAP/TAZ-TEAD facilitates the upregulation of multiple genes involved in evolutionary cell proliferation and survival. TEAD1–4 overexpression has been observed in diff

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Elisi, Gian, Matteo Santucci, Domenico D’Arca, et al. "Repurposing of Drugs Targeting YAP-TEAD Functions." Cancers 10, no. 9 (2018): 329. http://dx.doi.org/10.3390/cancers10090329.

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Drug repurposing is a fast and consolidated approach for the research of new active compounds bypassing the long streamline of the drug discovery process. Several drugs in clinical practice have been reported for modulating the major Hippo pathway’s terminal effectors, namely YAP (Yes1-associated protein), TAZ (transcriptional co-activator with PDZ-binding motif) and TEAD (transcriptional enhanced associate domains), which are directly involved in the regulation of cell growth and tissue homeostasis. Since this pathway is known to have many cross-talking phenomena with cell signaling pathways,

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Sung, Mi Sun, So Young Kim, Gwang Hyeon Eom, and Sang Woo Park. "High VEGF Concentrations Accelerate Human Trabecular Meshwork Fibrosis in a TAZ-Dependent Manner." International Journal of Molecular Sciences 24, no. 11 (2023): 9625. http://dx.doi.org/10.3390/ijms24119625.

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We aimed to investigate the effects of different concentrations of vascular endothelial growth factor (VEGF) on the extracellular matrix (ECM) and fibrotic proteins in human trabecular meshwork (TM) cells. We also explored how the Yes-associated protein (YAP)/transcriptional co-activator with PDZ-binding motif (TAZ) signaling pathway modulates VEGF-induced fibrosis. We determined cross-linked actin network (CLAN) formation using TM cells. Changes in fibrotic and ECM protein expression were determined. High VEGF concentrations (10 and 30 ng/mL) increased TAZ and decreased p-TAZ/TAZ expression i

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Qu, Huinan, Da Qi, Xinqi Wang, et al. "CLDN6 Suppresses c–MYC–Mediated Aerobic Glycolysis to Inhibit Proliferation by TAZ in Breast Cancer." International Journal of Molecular Sciences 23, no. 1 (2021): 129. http://dx.doi.org/10.3390/ijms23010129.

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Claudin 6 (CLDN6) was found to be a breast cancer suppressor gene, which is lowly expressed in breast cancer and inhibits breast cancer cell proliferation upon overexpression. However, the mechanism by which CLDN6 inhibits breast cancer proliferation is unclear. Here, we investigated this issue and elucidated the molecular mechanisms by which CLDN6 inhibits breast cancer proliferation. First, we verified that CLDN6 was lowly expressed in breast cancer tissues and that patients with lower CLDN6 expression had a worse prognosis. Next, we confirmed that CLDN6 inhibited breast cancer proliferation

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Shrestha, Madhu, Toshinori Ando, Chanbora Chea, et al. "The transition of tissue inhibitor of metalloproteinases from -4 to -1 induces aggressive behavior and poor patient survival in dedifferentiated liposarcoma via YAP/TAZ activation." Carcinogenesis 40, no. 10 (2019): 1288–97. http://dx.doi.org/10.1093/carcin/bgz023.

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AbstractLiposarcoma (LS) is the most common soft-tissue sarcoma. Dedifferentiated liposarcoma (DDLS) shows more aggressive biological behavior than that of well-differentiated liposarcoma (WDLS), so advanced therapeutic agents based on molecular mechanism are urgently needed. Here we show that tissue inhibitors of metalloproteinases (TIMPs) from TIMP-1 to TIMP-4 are differently expressed and regulate yes-associated protein (YAP)/transcriptional co-activator with PDZ binding motif (TAZ) in LS. Database analysis showed high TIMP-1 expression in DDLS patients correlating with poor prognosis, but

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Ando, Toshinori, Kento Okamoto, Tomoaki Shintani, et al. "Integrating Genetic Alterations and the Hippo Pathway in Head and Neck Squamous Cell Carcinoma for Future Precision Medicine." Journal of Personalized Medicine 12, no. 10 (2022): 1544. http://dx.doi.org/10.3390/jpm12101544.

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Genetic alterations and dysregulation of signaling pathways are indispensable for the initiation and progression of cancer. Understanding the genetic, molecular, and signaling diversities in cancer patients has driven a dynamic change in cancer therapy. Patients can select a suitable molecularly targeted therapy or immune checkpoint inhibitor based on the driver gene alterations determined by sequencing of cancer tissue. This “precision medicine” approach requires detailed elucidation of the mechanisms connecting genetic alterations of driver genes and aberrant downstream signaling pathways. T

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Ahmad, Usama Sharif, Jutamas Uttagomol, and Hong Wan. "The Regulation of the Hippo Pathway by Intercellular Junction Proteins." Life 12, no. 11 (2022): 1792. http://dx.doi.org/10.3390/life12111792.

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The Hippo pathway is an evolutionarily conserved pathway that serves to promote cell death and differentiation while inhibiting cellular proliferation across species. The downstream effectors of this pathway, yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ), are considered vital in promoting the output of the Hippo pathway, with activation of upstream kinases negatively regulating YAP/TAZ activity. The upstream regulation of the Hippo pathway is not entirely understood on a molecular level. However, several studies have shown that numerous cellular and

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Miyajima, Chiharu, Yurika Hayakawa, Yasumichi Inoue, Mai Nagasaka, and Hidetoshi Hayashi. "HMG-CoA Reductase Inhibitor Statins Activate the Transcriptional Activity of p53 by Regulating the Expression of TAZ." Pharmaceuticals 15, no. 8 (2022): 1015. http://dx.doi.org/10.3390/ph15081015.

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Transcriptional coactivator with PDZ-binding motif (TAZ) is a downstream transcriptional regulator of the Hippo pathway that controls cell growth and differentiation. The aberrant activation of TAZ correlates with a poor prognosis in human cancers, such as breast and colon cancers. We previously demonstrated that TAZ inhibited the tumor suppressor functions of p53 and enhanced cell proliferation. Statins, which are used to treat dyslipidemia, have been reported to suppress the activity of TAZ and exert anti-tumor effects. In the present study, we focused on the regulation of p53 functions by T

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Plewes, Michele R., Xiaoying Hou, Pan Zhang, et al. "Yes-associated protein 1 is required for proliferation and function of bovine granulosa cells in vitro†." Biology of Reproduction 101, no. 5 (2019): 1001–17. http://dx.doi.org/10.1093/biolre/ioz139.

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Abstract Yes-associated protein 1 (YAP1) is a major component of the Hippo signaling pathway. Although the exact extracellular signals that control the Hippo pathway are currently unknown, increasing evidence supports a critical role for the Hippo pathway in embryonic development, regulation of organ size, and carcinogenesis. Granulosa cells (GCs) within the ovarian follicle proliferate and produce steroids and growth factors, which facilitate the growth of follicle and maturation of the oocyte. We hypothesize that YAP1 plays a role in proliferation and estrogen secretion of GCs. In the curren

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Zuo, Q.-F., R. Zhang, B.-S. Li, et al. "MicroRNA-141 inhibits tumor growth and metastasis in gastric cancer by directly targeting transcriptional co-activator with PDZ-binding motif, TAZ." Cell Death & Disease 6, no. 1 (2015): e1623-e1623. http://dx.doi.org/10.1038/cddis.2014.573.

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Strakova, Zuzana, Jennifer Reed, Mark Livak, and Ivanna Ihnatovych. "Localization of Transcriptional Co-Activator with PDZ Binding Motif (TAZ) in Human Endometrium and Its Involvement in the Regulation of Decidualization." Biology of Reproduction 81, Suppl_1 (2009): 398. http://dx.doi.org/10.1093/biolreprod/81.s1.398.

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Zhao, Wanxia, Ziteng Wang, Yichen Lei, et al. "Investigating InDels in YAP and TAZ genes and their impact on growth characteristics in goats." Archives Animal Breeding 67, no. 3 (2024): 343–51. http://dx.doi.org/10.5194/aab-67-343-2024.

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Abstract. Yes-associated protein (YAP) and a transcriptional co-activator with PDZ-binding motif (TAZ) genes are crucial for regulating the size of mammalian tissues and organs as well as for many biological processes such as bone formation, cell lineage determination, tissue regeneration, and cell proliferation. The purpose of this study was to characterize the YAP and TAZ gene polymorphisms in 266 Guanzhong Dairy Goats and 299 Shanbei White Cashmere Goats and to explore their potential relationship with growth characteristics such as body weight and body length. After genotyping and using PC

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Cherrett, Claire, Makoto Furutani-Seiki, and Stefan Bagby. "The Hippo pathway: key interaction and catalytic domains in organ growth control, stem cell self-renewal and tissue regeneration." Essays in Biochemistry 53 (August 28, 2012): 111–27. http://dx.doi.org/10.1042/bse0530111.

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The Hippo pathway is a conserved pathway that interconnects with several other pathways to regulate organ growth, tissue homoeostasis and regeneration, and stem cell self-renewal. This pathway is unique in its capacity to orchestrate multiple processes, from sensing to execution, necessary for organ expansion. Activation of the Hippo pathway core kinase cassette leads to cytoplasmic sequestration of the nuclear effectors YAP (Yes-associated protein) and TAZ (transcriptional coactivator with PDZ-binding motif), consequently disabling their transcriptional co-activation function. Components upst

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Lee, Jieun, Moonhyung Choi, Seungyeon Joe, Kabsoo Shin, Sung-Hak Lee, and Ahwon Lee. "Growth Pattern of Hepatic Metastasis as a Prognostic Index Reflecting Liver Metastasis-Associated Survival in Breast Cancer Liver Metastasis." Journal of Clinical Medicine 11, no. 10 (2022): 2852. http://dx.doi.org/10.3390/jcm11102852.

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Breast cancer with liver metastasis (BCLM) frequently cause hepatic failure owing to extensive liver metastasis compared to other cancers; however, there are no clinicopathologic or radiologic parameters for estimating BCLM prognosis. We analyzed the relationship between radiologic and clinicopathologic characteristics with survival outcomes in BCLM. During 2009–2019, baseline and final abdomen computed tomography or liver magnetic resonance imaging of BCLM patients were reviewed. Liver metastasis patterns were classified as oligometastasis (≤3 metastatic lesions), non-confluent or confluent m

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Wan, Qiuyuan, Qing Chen, Dongge Cai, Yan Zhao, and Xiaoling Wu. "OTUB2 Promotes Homologous Recombination Repair Through Stimulating Rad51 Expression in Endometrial Cancer." Cell Transplantation 29 (January 1, 2020): 096368972093143. http://dx.doi.org/10.1177/0963689720931433.

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Genetic instability, raised from dysregulation of DNA repair, is involved in tumor development. OTUB2 (ovarian tumor domain protease domain-containing ubiquitin aldehyde-binding protein 2), which is responsible for DNA double-strand break (DSB), is implicated in carcinogenesis of various tumors. The effect of OTUB2 on endometrial cancer progression was then investigated. First, OTUB2 was found to be upregulated in endometrial cancer tissues and cell lines, and was closely associated with overall survival of endometrial cancer patients. Cell Counting Kit-8 and flow cytometry assay results revea

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Liu, Fei, David Lagares, Kyoung Moo Choi, et al. "Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis." American Journal of Physiology-Lung Cellular and Molecular Physiology 308, no. 4 (2015): L344—L357. http://dx.doi.org/10.1152/ajplung.00300.2014.

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Pathological fibrosis is driven by a feedback loop in which the fibrotic extracellular matrix is both a cause and consequence of fibroblast activation. However, the molecular mechanisms underlying this process remain poorly understood. Here we identify yes-associated protein (YAP) (homolog of drosophila Yki) and transcriptional coactivator with PDZ-binding motif (TAZ) (also known as Wwtr1), transcriptional effectors of the Hippo pathway, as key matrix stiffness-regulated coordinators of fibroblast activation and matrix synthesis. YAP and TAZ are prominently expressed in fibrotic but not health

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Wang, Chenji, Jian An, Pingzhao Zhang, et al. "The Nedd4-like ubiquitin E3 ligases target angiomotin/p130 to ubiquitin-dependent degradation." Biochemical Journal 444, no. 2 (2012): 279–89. http://dx.doi.org/10.1042/bj20111983.

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AMOT (angiomotin) is a membrane-associated protein that is expressed in ECs (endothelial cells) and controls migration, TJ (tight junction) formation, cell polarity and angiogenesis. Recent studies have revealed that AMOT and two AMOT-like proteins, AMOTL1 and AMOTL2, play critical roles in the Hippo pathway by regulating the subcellular localization of the co-activators YAP (Yes-associated protein) and TAZ (transcriptional co-activator with PDZ-binding motif). However, it has been unclear how AMOT is regulated. In the present study, we report that AMOT undergoes proteasomal degradation. We id

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Mondal, Varsha, Paul J. Higgins, and Rohan Samarakoon. "Emerging Role of Hippo-YAP (Yes-Associated Protein)/TAZ (Transcriptional Coactivator with PDZ-Binding Motif) Pathway Dysregulation in Renal Cell Carcinoma Progression." Cancers 16, no. 15 (2024): 2758. http://dx.doi.org/10.3390/cancers16152758.

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Although Hippo-YAP/TAZ pathway involvement has been extensively studied in the development of certain cancers, the involvement of this cascade in kidney cancer progression is not well-established and, therefore, will be the focus of this review. Renal cell carcinoma (RCC), the most prevalent kidney tumor subtype, has a poor prognosis and a high mortality rate. Core Hippo signaling inactivation (e.g., LATS kinases) leads to the nuclear translocation of YAP/TAZ where they bind to co-transcriptional factors such as TEAD promoting transcription of genes which initiates various fibrotic and neoplas

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Wang, Yongshun, Wei Cao, Jinjin Cui, et al. "Arterial Wall Stress Induces Phenotypic Switching of Arterial Smooth Muscle Cells in Vascular Remodeling by Activating the YAP/TAZ Signaling Pathway." Cellular Physiology and Biochemistry 51, no. 2 (2018): 842–53. http://dx.doi.org/10.1159/000495376.

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Background/Aims: Increasing wall stress or biomechanical stretch experienced by arteries influences the initiation of atherosclerotic lesions. This initiation is mediated by Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ), which are both effectors of the Hippo pathway. In this study, the functional roles of YAP/TAZ proteins in the regulation of the stretch-mediated programing of human umbilical arterial smooth muscle cells (HUASMCs) to a proliferative phenotype were examined. Methods: HUASMCs were seeded on a Matrigel-coated silicone chamber and subje

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Laiman, Vincent, Didik Setyo Heriyanto, Yueh-Lun Lee, et al. "Zinc Oxide Nanoparticles Promote YAP/TAZ Nuclear Localization in Alveolar Epithelial Type II Cells." Atmosphere 13, no. 2 (2022): 334. http://dx.doi.org/10.3390/atmos13020334.

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We investigated roles of Hippo signaling pathway components in alveolar type II cells (AECII) after zinc oxide nanoparticle (ZnONP) exposure. ZnONPs physicochemistry was characterized using field emission-scanning electron microscopy (FE-SEM) and energy-dispersive X-ray (EDX) microanalysis. ZnONP deposition in human respiratory tract was estimated using multiple-path particle dosimetry (MPPD) model. MLE-12 AECII were cultured and exposed to 0, 1, and 5 μg/mL of ZnONPs for 24 h. Western blots were used to investigate signaling pathways associated with Yes-associated protein (YAP)/transcriptiona

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Kodaka, Manami, Fengju Mao, Kyoko Arimoto-Matsuzaki, et al. "Characterization of a novel compound that promotes myogenesis via Akt and transcriptional co-activator with PDZ-binding motif (TAZ) in mouse C2C12 cells." PLOS ONE 15, no. 4 (2020): e0231265. http://dx.doi.org/10.1371/journal.pone.0231265.

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Umegaki, Toshihito, Hisashi Moriizumi, Fumiko Ogushi, Mutsuhiro Takekawa, and Takashi Suzuki. "Molecular dynamics simulations of a multicellular model with cell-cell interactions and Hippo signaling pathway." PLOS Computational Biology 20, no. 11 (2024): e1012536. http://dx.doi.org/10.1371/journal.pcbi.1012536.

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The transcriptional coactivator Yes-associated protein (YAP)/transcriptional co-activator with PDZ binding motif (TAZ) induces cell proliferation through nuclear localization at low cell density. Conversely, at extremely high cell density, the Hippo pathway, which regulates YAP/TAZ, is activated. This activation leads to the translocation of YAP/TAZ into the cytoplasm, resulting in cell cycle arrest. Various cancer cells have several times more YAP/TAZ than normal cells. However, it is not entirely clear whether this several-fold increase in YAP/TAZ alone is sufficient to overcome proliferatio

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Hong, Ganji, Ying Yan, Yali Zhong, Jianer Chen, Fei Tong, and Qilin Ma. "Combined Ischemic Preconditioning and Resveratrol Improved Bloodbrain Barrier Breakdown via Hippo/YAP/TAZ Signaling Pathway." CNS & Neurological Disorders - Drug Targets 18, no. 9 (2020): 713–22. http://dx.doi.org/10.2174/1871527318666191021144126.

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Background: Transient Ischemia/Reperfusion (I/R) is the main reason for brain injury and results in disruption of the Blood-Brain Barrier (BBB). It had been reported that BBB injury is one of the main risk factors for early death in patients with cerebral ischemia. Numerous investigations focus on the study of BBB injury which have been carried out. Objective: The objective of this study was to investigate the treatment function of the activation of the Hippo/Yes-Associated Protein (YAP) signaling pathway by combined Ischemic Preconditioning (IPC) and resveratrol (RES) before brain Ischemia/Re

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Lee, Hyun Ji, Yong Jun Hong, and Miri Kim. "Angiogenesis in Chronic Inflammatory Skin Disorders." International Journal of Molecular Sciences 22, no. 21 (2021): 12035. http://dx.doi.org/10.3390/ijms222112035.

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Angiogenesis, the growth of new blood vessels from preexisting vessels, is associated with inflammation in various pathological conditions. Well-known angiogenetic factors include vascular endothelial growth factor (VEGF), angiopoietins, platelet-derived growth factor, transforming growth factor-β, and basic fibroblast growth factor. Yes-associated protein 1 (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) have recently been added to an important angiogenic factor. Accumulating evidence indicates associations between angiogenesis and chronic inflammatory skin diseases. Angio

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Steinberg, Thorsten, Martin Philipp Dieterle, Imke Ramminger, et al. "On the Value of In Vitro Cell Systems for Mechanobiology from the Perspective of Yes-Associated Protein/Transcriptional Co-Activator with a PDZ-Binding Motif and Focal Adhesion Kinase and Their Involvement in Wound Healing, Cancer, Aging, and Senescence." International Journal of Molecular Sciences 24, no. 16 (2023): 12677. http://dx.doi.org/10.3390/ijms241612677.

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Mechanobiology comprises how cells perceive different mechanical stimuli and integrate them into a process called mechanotransduction; therefore, the related mechanosignaling cascades are generally important for biomedical research. The ongoing discovery of key molecules and the subsequent elucidation of their roles in mechanobiology are fundamental to understanding cell responses and tissue conditions, such as homeostasis, aging, senescence, wound healing, and cancer. Regarding the available literature on these topics, it becomes abundantly clear that in vitro cell systems from different spec

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Tang, Miaolu, Kaitlyn Dirks, Soo Yeon Kim, Jessica Thorpe, and Wei Li. "Abstract 2910: Targeting thioredoxin reductase 1 (TrxR1) suppresses TAZ-driven glioblastoma progression." Cancer Research 84, no. 6_Supplement (2024): 2910. http://dx.doi.org/10.1158/1538-7445.am2024-2910.

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Abstract Glioblastoma (GBM) is the most common and aggressive primary brain malignancy in adults. Poor outcomes for traditional treatments demand targeted therapies based on identified mechanisms that drive tumor development and sustain its malignancy. Molecular pathology studies have classified GBM into subtypes differing in treatment responses and survival rates. Among these subtypes, the mesenchymal (MES) group is associated with the worst prognosis. The Hippo pathway transcriptional co-activator with PDZ-binding motif (TAZ) is one of the three transcriptional regulators that drive the GBM

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Mohagheghi, Sina, Zohreh Khajehahmadi та Heidar Tavilani. "Signaling in Simple Steatosis and Non-alcoholic Steatohepatitis Cirrhosis: TGF-β1, YAP/TAZ, and Hedgehog Pathway Activity". Avicenna Journal of Medical Biochemistry 6, № 2 (2018): 26–30. http://dx.doi.org/10.15171/ajmb.2018.07.

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Non-alcoholic fatty liver disease (NAFLD) refers to the accumulation of fat in the liver tissue that is usually associated with metabolic disorders. Traditionally, the disease is regarded as a spectrum of pathological conditions ranging from simple steatosis (SS) to non-alcoholic steatohepatitis (NASH) and hepatic fibrosis with progression to cirrhosis. However, so far, there is no available explanation for the disease progression. Several signaling pathways such as transforming growth factor (TGF)-β, hedgehog (HH), and yes-associated protein 1 (YAP)/transcriptional coactivator with PDZ-bindin

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Masliantsev, Konstantin, Lucie Karayan-Tapon, and Pierre-Olivier Guichet. "Hippo Signaling Pathway in Gliomas." Cells 10, no. 1 (2021): 184. http://dx.doi.org/10.3390/cells10010184.

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The Hippo signaling pathway is a highly conserved pathway involved in tissue development and regeneration that controls organ size through the regulation of cell proliferation and apoptosis. The core Hippo pathway is composed of a block of kinases, MST1/2 (Mammalian STE20-like protein kinase 1/2) and LATS1/2 (Large tumor suppressor 1/2), which inhibits nuclear translocation of YAP/TAZ (Yes-Associated Protein 1/Transcriptional co-activator with PDZ-binding motif) and its downstream association with the TEAD (TEA domain) family of transcription factors. This pathway was recently shown to be invo

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Chen, Yen-Lin, I.-Chuan Yen, Kuen-Tze Lin, Feng-Yi Lai та Shih-Yu Lee. "4-Acetylantrocamol LT3, a New Ubiquinone from Antrodia cinnamomea, Inhibits Hepatocellular Carcinoma HepG2 Cell Growth by Targeting YAP/TAZ, mTOR, and WNT/β-Catenin Signaling". American Journal of Chinese Medicine 48, № 05 (2020): 1243–61. http://dx.doi.org/10.1142/s0192415x20500615.

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4-acetylantrocamol LT3 (4AALT3), a new ubiquinone from the mycelium of Antrodia cinnamomea (Polyporaceae), has been recently shown to possess anticancer activity. However, the detailed mechanisms of such action remain unclear. In this study, the molecular mechanisms of 4AALT3 on hepatocellular carcinoma cells (HCC) were investigated. Human hepatocellular carcinoma cell line HepG2 cells were treated with concentrations of 4AALT3. Cell viability, colony formation, and the underlying mechanisms were then analyzed by CCK-8, colony formation, qPCR, and Western blotting assays. We found that 4AALT3

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Abou Nader, Nour, Amélie Ménard, Adrien Levasseur, et al. "Targeted Disruption of Lats1 and Lats2 in Mice Impairs Testis Development and Alters Somatic Cell Fate." International Journal of Molecular Sciences 23, no. 21 (2022): 13585. http://dx.doi.org/10.3390/ijms232113585.

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Hippo signaling plays an essential role in the development of numerous tissues. Although it was previously shown that the transcriptional effectors of Hippo signaling Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) can fine-tune the regulation of sex differentiation genes in the testes, the role of Hippo signaling in testis development remains largely unknown. To further explore the role of Hippo signaling in the testes, we conditionally deleted the key Hippo kinases large tumor suppressor homolog kinases 1 and -2 (Lats1 and Lats2, two kinases that ant

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Ji, Xinyan, Lihua Song, Li Sheng, et al. "Cyclopeptide RA-V Inhibits Organ Enlargement and Tumorigenesis Induced by YAP Activation." Cancers 10, no. 11 (2018): 449. http://dx.doi.org/10.3390/cancers10110449.

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The Hippo pathway restricts organ size during development and its inactivation plays a crucial role in cancer. Yes-associated protein (YAP) and its paralog transcriptional coactivator with PSD-95/Dlg/ZO-1 (PDZ)-binding motif (TAZ) are transcription co-activators and effectors of the Hippo pathway mediating aberrant enlargement of organs and tumor growth upon Hippo pathway inactivation. It has been demonstrated that genetic inactivation of YAP could be an effective approach to inhibit tumorigenesis. In order to identify pharmacological inhibitors of YAP, we screened a library of 52,683 compound

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