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1

Perona, G., R. Schiavon, G. C. Guidi, D. Veneri, and P. Minuz. "Selenium Dependent Glutathione Peroxidase: A Physiological Regulatory System for Platelet Function." Thrombosis and Haemostasis 64, no. 02 (1990): 312–18. http://dx.doi.org/10.1055/s-0038-1647308.

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SummaryIn human platelets the selenoenzyme glutathione peroxidase (GSH-Px) acts as a scavenger of the peroxides generated during the burst of arachidonic acid (AA) metabolism. Such a mechanism inhibits the biosynthesis of both thromboxane A2 (TXA2) and lipoxygenase products. The same mechanism is not effective on the prostacyclin (PGI2) biosynthesis from cultured endothelial cells. In order to evaluate this effect in vivo, besides in vitro, we activated the enzyme in eight normal volunteers by increasing their daily Se intake for 8 weeks, monitoring: platelet GSH-Px activity, platelet aggregat
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Baj, Z., K. Zeman, Ewa Majewska, et al. "Does the Selenium (SE) Level and Se-Dependent Enzyme Activity in Blood Plasma Correlate with Human Lymphocyte Subpopulations and Function?" International Journal of Immunopathology and Pharmacology 5, no. 1 (1992): 13–21. http://dx.doi.org/10.1177/039463209200500102.

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Recent literature data on the effects of Se on subpopulations of T lymphocytes, on autologous mixed lymphocyte reaction (AMLR) and on natural killer (NK) cell cytotoxicity are limited or poorly defined. In healthy volunteers we have estimated se levels, glutathione peroxidase (GSH-Px) activity and lipid peroxide levels in human plasma and simultaneously, the subpopulations of T lymphocytes, proliferation in AMLR, and activity of NK cells. We found a significantly positive correlation between the selenium level and GSH-Px activity. The proliferative response in AMLR significantly correlated wit
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Zachara, Bronisław A., Jolanta Gromadzińska, Wojciech Wasowicz, and Zbigniew Zbróg. "Red blood cell and plasma glutathione peroxidase activities and selenium concentration in patients with chronic kidney disease: a review." Acta Biochimica Polonica 53, no. 4 (2006): 663–77. http://dx.doi.org/10.18388/abp.2006_3294.

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The metabolism of oxygen in aerobic organisms leads to generation of reactive oxygen species (ROS). These entities are able to oxidize almost all classes of macromolecules, including proteins, lipids and nucleic acids. The physiological level of ROS is usually regulated by antioxidant defense mechanisms. There are at least three groups of antioxidant enzymes: superoxide dismutases, catalases and glutathione peroxidases (GSH-Pxs) which neutralize ROS. The trace elements (copper, zinc and selenium) bound to the active sites of the above listed enzymes play an important role in the antioxidant de
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4

Karakılçık, A. Ziya, and Mesut Aksakal. "Some Metabolic Functions and Metabolism of Selenium and its relations with Vitamin E." European Journal of Therapeutics 4, no. 2 (1993): 283–91. http://dx.doi.org/10.58600/eurjther-199342-1111-x.

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Selenium (Se) concentrations in the animal tissues vary according to the tissue and the amount and chemical form of Se in diet. in cattle and sheep Se concentrations rank in the order kidney, Iiver, heart, skeletal muscle and adipose tissue. Se like other elements, has a bimodal effect. At normal concentrations, Se is an essential trace element necessary for growth in man and animals. However, ıntake of high concentrations of Se can show toxic effects; ingestion of very low concentrations of this trace element results in Se-deficiency sympthoms in man and animals. The main physiological functi
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5

Kalashnikov, S. V., and M. V. Shkidyuk. "Identification characteristics of non-smoking tobacco products." New Technologies 17, no. 2 (2021): 25–32. http://dx.doi.org/10.47370/2072-0920-2021-17-2-25-32.

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Modern trends in the reduction of cigarette consumption have led to the spread of smokeless tobacco and non-tobacco nicotine-containing products [1]; their variety creates certain problems with the identification of products in this segment. Sucking tobacco (snus) has been banned in the Russian Federation for wholesale and retail trade since 2015, but it is a product similar to chew- ing tobacco in packaging, ingredient composition and physiological effects. Therefore, establishing the identification characteristics of chewing tobacco is an urgent task. The attitude towards chewing tobacco is
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6

Cui, Boya, Lanying Liu, Tao Shi, Min Yin, Xu Feng, and Yu Shan. "The Ethanolic Extract of Lycium ruthenicum Ameliorates Age-Related Physiological Damage in Mice." Molecules 28, no. 22 (2023): 7615. http://dx.doi.org/10.3390/molecules28227615.

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Aging and age-related diseases are important study topics due to their associations with progressive physiological damage to genes, cells, tissues, and the entire organism, which ultimately affects the functional efficiency of organs. Lycium ruthenicum Murr. is a functional food that is known for its high contents of anthocyanins and spermidines, both of which have been demonstrated to have positive effects on anti-aging activity and anti-oxidation. In this study, we used HPLC-MS to analyze the constituents of L. ruthenicum Murr. Extract (LRM) and investigated their potential mechanism for exe
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7

Wang, Jian, Li Zhang, Xia Tang, et al. "The Effect of Lidan Huashi Pills on the Glutathione Peroxidase Activity and Growth of Calcium Oxalate Crystals in the Kidneys of Rats." Urology Research 2, no. 2 (2024): 1–9. http://dx.doi.org/10.26689/ur.v2i2.7397.

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Objective: To explore the effects of Lidan Huashi Pills on the glutathione peroxidase (GSH-Px) activity and growth of calcium oxalate crystals in the kidneys of rats. Methods: 30 rats were randomly divided into a blank group, a model group, and an experimental group, with 10 rats in each group. The blank group was free to eat and drink water for 8 weeks; the ethylene glycol method was used for the standard calcium oxalate crystal modeling in the control group and experimental group for 4 weeks. The model group was given free feeding and physiological saline (2 ml/d) by continuous gavage for 4
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8

Lin, Qianmin, Bingbing Song, Yingxiong Zhong, et al. "Effect of Sodium Hyaluronate on Antioxidant and Anti-Ageing Activities in Caenorhabditis elegans." Foods 12, no. 7 (2023): 1400. http://dx.doi.org/10.3390/foods12071400.

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As an acidic polysaccharide, the formation of Hyaluronic acid (HA) is typically Sodium Hyaluronate (SH) for knee repair, oral treatment, skincare and as a food additive. Nevertheless, little information is available on the anti-ageing activity of SH as a food additive. Therefore, we treated C. elegans with SH, then inferred the anti-aging activity of SH by examining the lifespan physiological indicators and senescence-associated gene expression. Compared with the control group, SH (800 μg/mL) prolonged the C. elegans’ lifespans in regular, 35 °C and H2O2 environment by 0.27-fold, 0.25-fold and
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9

Zhang, Shuyi, Weichang Gao, Kai Cai, Taoze Liu, and Xingshi Wang. "Effects of Microplastics on Growth and Physiological Characteristics of Tobacco (Nicotiana tabacum L.)." Agronomy 12, no. 11 (2022): 2692. http://dx.doi.org/10.3390/agronomy12112692.

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The environmental effects caused by the proliferation of microplastics have received extensive attention. However, at this stage, there is a lack of research on the toxicology of microplastics and their impacts on plants. This study explored the effects of microplastics on the growth and physiological characteristics of tobacco. Using tobacco (Nicotiana tabacum L.) variety Yunyan87 and low-density polyethylene (LDPE, 13 μm particle size), different concentrations, which were 0 mg/L (CK), 10 mg/L (T1), 100 mg/L (T2), and 1000 mg/L (T3), were subjected to hydroponic experiments to study the effe
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10

Gu, Chunmei, Qiuping Yang, Shujun Li, et al. "Effects of Soybean Trypsin Inhibitor on Pancreatic Oxidative Damage of Mice at Different Growth Periods." Foods 12, no. 8 (2023): 1691. http://dx.doi.org/10.3390/foods12081691.

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The bioactive components in soybeans have significant physiological functions. However, the intake of soybean trypsin inhibitor (STI) may cause metabolic disorders. To investigate the effect of STI intake on pancreatic injury and its mechanism of action, a five-week animal experiment was conducted, meanwhile, a weekly monitor on the degree of oxidation and antioxidant indexes in the serum and pancreas of the animals was carried out. The results showed that the intake of STI had irreversible damage to the pancreas, according to the analysis of the histological section. Malondialdehyde (MDA) in
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11

Anuradha, M., K. Sivaraju, and V. Krishnamurthy. "Effect of waterlogging on physiological characteristics, yield and quality of flue-cured tobacco." Indian Journal of Plant Physiology 18, no. 1 (2013): 67–70. http://dx.doi.org/10.1007/s40502-013-0008-0.

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12

Shar, Abdul Ghaffar, Sadam Hussain, Muhammad Bilawal Junaid, et al. "Melatonin Ameliorates Cadmium Toxicity in Tobacco Seedlings by Depriving Its Bioaccumulation, Enhancing Photosynthetic Activity and Antioxidant Gene Expression." Plants 13, no. 21 (2024): 3049. http://dx.doi.org/10.3390/plants13213049.

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Soil remediation for cadmium (Cd) toxicity is essential for successful tobacco cultivation and production. Melatonin application can relieve heavy metal stress and promote plant growth; however, it remains somewhat unclear whether melatonin supplementation can remediate the effects of Cd toxicity on the growth and development of tobacco seedlings. Herein, we evaluated the effect of soil-applied melatonin on Cd accumulation in tobacco seedlings, as well as the responses in growth, physiological and biochemical parameters, and the expression of stress-responsive genes. Our results demonstrate th
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13

Lopes, Camila Aparecida, Maria Laene Moreira de Carvalho, Renato Mendes Guimarães, Ariadne Morbeck Santos de Oliveira, and Dayliane Bernardes de Andrade. "Sodium hypochlorite in the priming of tobacco seeds." Journal of Seed Science 41, no. 1 (2019): 108–11. http://dx.doi.org/10.1590/2317-1545v41n1211719.

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Abstract: Due to the non-uninform maturation of tobacco fruits and seeds, the priming technique has been used by the tobacco industry as a way of increasing the uniformity and germinations peed of seeds. Several factors can affect priming, including the time and environment in which the treatment is performed. In order to evaluate the effect of sodium hypochlorite as priming agent at different concentrations and the priming period on the physiological quality of the tobacco seeds, it was used a seed lot of commercial cultivar CSC 439 from the Virginia varietal group, widely used by the produci
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14

Khang, Nguyen Thi Kim, Ngo Thi Minh Suong, and Masashi Takahashi. "Impact of heat stress on blood physiological parameters, body temperature, respiratory frequency, antioxidant status, carcass quality, production performance, and egg quality of Japanese quails." Veterinary Integrative Sciences 22, no. 3 (2023): 831–46. http://dx.doi.org/10.12982/vis.2024.056.

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The study was performed with three experiments. The first experiment studied respiratory rate (RR), body temperature (BT), blood physiological parameters (BPP), serum antioxidant enzyme activities (SAEA), and meat quality of 240 quails under three temperatures (38 °C, 25 °C, and environmental temperature 30 °C) and two bodyweights (heavy and lighter). Heat stress (HS) increased RR and BT of quails but had no effect on BPP; superoxide dismutase (SOD) activity was decreased in group 38 °C (P<0.05), and a trend of increasing glutathione peroxidase (GSH-Px) was also observed in group 38 °C (P=0
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15

Liao, Xianyan, Nannan Chen, Peng Feng, Ping Li, Zhanmin Liu, and Junyi Huang. "Physiological effect of graphene oxide on tobacco BY-2 suspension cells and its immigration." Vibroengineering PROCEDIA 11 (May 30, 2017): 129–34. http://dx.doi.org/10.21595/vp.2017.18409.

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16

Mousa, Amria M., Nermin M. El-Sammad, Abeer H. Abdel-Halim, et al. "Lagerstroemia Speciosa (L.) Pers Leaf Extract Attenuates Lung Tumorigenesis via Alleviating Oxidative Stress, Inflammation and Apoptosis." Biomolecules 9, no. 12 (2019): 871. http://dx.doi.org/10.3390/biom9120871.

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One of the major etiological factors that account for lung cancer is tobacco use. Benzo(a)pyrene [B(a)P], one of the main constituents of tobacco smoke, has a key role in lung carcinogenesis. The present study was conducted to investigate the cytotoxicity of an aqueous ethanolic extract of Lagerstroemia speciosa (L.) Pers leaves (LLE) on human lung adenocarcinoma cells (A549), as well as its in vivo antitumor effect on a lung tumorigenesis mice model. Our results revealed that LLE possesses cytotoxic activity against the A549 cell line. Mice orally administered B(a)P (50 mg/kg body weight) sho
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17

Beattie, Erin, Jeffery Edmiston, Patrudu Makena, Elizabeth Mason, Mike McEwan, and Krishna Prasad. "Review of recent lung biomarkers of potential harm/effect for tobacco research." F1000Research 10 (December 17, 2021): 1293. http://dx.doi.org/10.12688/f1000research.55411.1.

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Biomarkers of potential harm (BoPH) are indicators of biological perturbations which may contribute to the pathophysiology of disease. In this review, we critically assessed the published data on lung-related BoPH in human lung disease for potential use in evaluating the effects of tobacco and nicotine products. A Scopus literature search was conducted on lung disease biomarkers used in a clinical setting over the last 10 years. We identified 1171 papers which were further screened using commercial software (Sciome SWIFT-Active Screener) giving 68 publications that met our inclusion criteria (
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18

Chandrasekaran, Rajamanickam, Kannan Revathi, Selvamathiazhagan Nisha, Suyambulingam Arunachalam Kirubakaran, Subbiah Sathish-Narayanan, and Sengottayan Senthil-Nathan. "Physiological effect of chitinase purified from Bacillus subtilis against the tobacco cutworm Spodoptera litura Fab." Pesticide Biochemistry and Physiology 104, no. 1 (2012): 65–71. http://dx.doi.org/10.1016/j.pestbp.2012.07.002.

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Song, Ruifang, Waqar Ahmed, Yujiao Tan, and Zhengxiong Zhao. "Diff erent Levels of Nitrogen Fertilizer in Nursery Stage Positively Aff ect the Activity of Defense-related Enzymes and Resistance of Tobacco Plant to Phytophthora nicotianae." Chiang Mai Journal of Science 49, no. 3 (2022): 551–64. http://dx.doi.org/10.12982/cmjs.2022.046.

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Black shank caused by Phytophthora nicotianae is a serious threat to the production of better-quality fl ue-cured tobacco. Protein’s are executors of plant functions and most disease resistance mechanisms in plants are related to differential expression of proteins. In our previous study, 17 different proteins induced by P. nicotianae were screened out through proteomics analysis. In this study, we evaluated the effect of three different levels of nitrogen fertilizer (High, medium, and low) at the seedling stage on the expression of these proteins, physiological response of fl ue-cured tobacco
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Kostadinović, Ljiljana M., Sava T. Pavkov, Jovanka D. Lević, Tamara A. Galonja-Coghill, Gordana K. Dozet, and Nenad Č. Bojat. "Effect of sulphachloropyrazine on antioxidative systems in blood and liver of broilers." Acta Veterinaria Brno 80, no. 2 (2011): 165–70. http://dx.doi.org/10.2754/avb201180020165.

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This report describes the effects of therapeutic doses of coccidiocid sulphachloropyrazine on enzymatic and non-enzymatic antioxidative systems in haemolysed blood and liver homogenate from broilers (glutathione, glutathione-reductase, glutathione-peroxidase, peroxidase, superoxide-dismutase, xantine-oxidase and lipid peroxidation). The in vivo investigation was carried out on 120 heavy-line broilers (Arbor acres) of both sexes. One-day-old broilers were randomly distributed into 2 groups, each numbering 60 individuals of both sexes: Group 1 - control group; Group 2 - group of broilers inocula
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Kuzmicheva, N. A., I. V. Mikhailova, I. N. Chaynikova, L. A. Pushkareva, Yu V. Filippova, and A. I. Smolyagin. "Effect of second-hand smoke on the immunological parameters of wistar rats and their offspring." Russian Journal of Immunology 24, no. 2 (2021): 215–20. http://dx.doi.org/10.46235/1028-7221-1014-eos.

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The literature covers multiple negative effects of active and passive tobacco smoking upon the human body and experimental animals. Much lesser attention is given to the features of the immune system in offspring from the passively smoking experimental animals. In previous works, we studied physiological and immunological parameters in the infant rats born from passively smoking rats. The present work expands the scope of this direction and is devoted to assessment of immunological parameters in passively smoking pregnant rats and their offspring. Quantitative determination of immunological pa
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22

Wang, Meng, Silin Wu, Benshun Yang, et al. "Grape Seed Proanthocyanidins Improve the Quality of Fresh and Cryopreserved Semen in Bulls." Animals 13, no. 17 (2023): 2781. http://dx.doi.org/10.3390/ani13172781.

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Oxidative stress leads to a decrease in semen quality during semen cryopreservation and fresh semen production. Grape seed proanthocyanidins (GSPs) are endowed with well-recognized antioxidant, anti-inflammatory, anti-cancer, and anti-aging activities. Therefore, the objective of this experiment was to explore the effects of GSPs on the quality of fresh and cryopreserved semen to provide a basis for GSPs as a new dietary additive and semen diluent additive for males’ reproduction. Fresh semen from three healthy bulls aged 3 to 5 years old were gathered and mixed with semen diluents dissolved w
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23

Matos, Ângelo Paggi, Regina Coeli de Oliveira Torres, Luiz Rodrigo Ito Morioka, Elisa Helena Siegel Moecke, Kepler Borges França, and Ernani Sebastião Sant’Anna. "GrowingChlorella vulgarisin Photobioreactor by Continuous Process Using Concentrated Desalination: Effect of Dilution Rate on Biochemical Composition." International Journal of Chemical Engineering 2014 (2014): 1–6. http://dx.doi.org/10.1155/2014/310285.

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Desalination wastewater, which contains large amount of salt waste, might lead to severely environmental pollution. This study evaluated the effect of dilution rate (0.1≤D≤0.3day−1) on microalgal biomass productivity, lipid content, and fatty acid profile under steady-state condition ofChlorella vulgarissupplemented with concentrated desalination. Continuous culture was conducted for 55 days. Results show that the biomass productivity (Px) varied from 57 to 126 mg L−1 d−1(dry mass) when the dilution rate ranged from 0.1 to 0.3 day−1. At lowest dilution rate (D=0.1day−1), the continuous culture
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24

Raldugina, Galina N., Sergey V. Evsukov, Liliya R. Bogoutdinova, Alexander A. Gulevich, and Ekaterina N. Baranova. "Morpho-Physiological Testing of NaCl Sensitivity of Tobacco Plants Overexpressing Choline Oxidase Gene." Plants 10, no. 6 (2021): 1102. http://dx.doi.org/10.3390/plants10061102.

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In this study the transgenic lines (TLs) of tobacco (Nicotianatabacum L.), which overexpress the heterologous gene encoding the bacterial enzyme choline oxidase were evaluated. The goal of our work is to study the effect of choline oxidase gene expression on the sensitivity of plant tissues to the action of NaCl. The regenerative capacity, rhizogenesis, the amount of photosynthetic pigments and osmotically active compounds (proline and glycine betaine) were assessed by in vitro cell culture methods using biochemical and morphological parameters. Transgenic lines with confirmed expression were
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Wu, Fan, Changquan Wang, Bing Li, et al. "EFFECT OF ECO-PHYSIOLOGICAL FACTORS ON THE TOBACCO POTASSIUM CONTENT IN HUILI COUNTY, SICHUANG PROVINCE, CHINA." Environmental and Earth Sciences Research Journal 1, no. 1 (2014): 1–6. http://dx.doi.org/10.18280/eesrj.010101.

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Liu, Yuechong, Lu Zheng, Bingying Xu, Gladstone Sagada, Jinzhi Zhang, and Qingjun Shao. "Effects of Diets with Varying Astaxanthin from Yarrowia lipolytica Levels on the Growth, Feed Utilization, Metabolic Enzymes Activities, Antioxidative Status and Serum Biochemical Parameters of Litopenaeus vannamei." Fishes 7, no. 6 (2022): 352. http://dx.doi.org/10.3390/fishes7060352.

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Litopenaeus vannamei was divided into seven groups (defined as diets A0–A6) and fed with diets respectively containing 0, 0.5, 1, 2, 4 and 8 g/kg Yarrowia lipolytica (astaxanthin content: 1.5%) and 3 g/kg Haematococcus pluvialis (astaxanthin content: 2%). After an eight-week feeding trial, the results reflected that different levels of Y. lipolytica and H. pluvialis could significantly increase the weight gain rate of L. vannamei (p < 0.05). The condition factor and weight gain rate of group A4 were significantly higher than those of the other groups (p < 0.05); the HSI significantly dec
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Liu, Xiaoyi, Lili Jiang, Jiaman Pang та ін. "Maternal Dietary Supplementation with γ-Aminobutyric Acid Alleviated Oxidative Stress in Gestating Sows and Their Offspring by Regulating GABRP". Animals 12, № 19 (2022): 2539. http://dx.doi.org/10.3390/ani12192539.

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Sows usually suffer oxidative stress during gestation, and this limits the growth of fetuses via placenta. Gamma-aminobutyric acid (GABA) is a functional nonessential amino acid engaged in regulating the physiological status of animals. However, the effects of GABA on the oxidative homeostasis of sows and their offspring remain unclear. Eighteen late gestating sows (85 d) were divided into the CON and GABA groups and fed the basal diet and the GABA diet (200 mg/kg GABA), respectively, until farrowing. At parturition, the sows’ litter characteristics, the plasma antioxidant parameters of sows,
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Yu, Hui Ping, Ding Qi Luo, Yuan Feng Dai, and Xue Chen. "Screening and Control Effects of Antagonistic Bacteria against Tobacco Black Shank Disease." Applied Mechanics and Materials 737 (March 2015): 374–80. http://dx.doi.org/10.4028/www.scientific.net/amm.737.374.

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We collected 17 soil samples from tobacco fields in Bijie City, Guizhou Province, Luzhou City, Sichuan Province. A total of 247 bacterial strains were isolated and 19 pairs of antagonism against Phytophthora nicotianae by tablet dual culture. Then six antagonistic and compatibility better bacterial strains were selected.. Further by antibacterial, pot and field experiments, come to the strain combination B41B57 and L7L47 have best inhibitory effect. At last, identified B41 as Bacillus subtilis, L7, L47 is B.amyloliquefaciens, B57 is Pseudomonas.putida by morphological observation, physiologica
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Khan, Rayyan, Peilu Zhou, Xinghua Ma, et al. "Transcriptome Profiling, Biochemical and Physiological Analyses Provide New Insights towards Drought Tolerance in Nicotiana tabacum L." Genes 10, no. 12 (2019): 1041. http://dx.doi.org/10.3390/genes10121041.

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Drought stress is one of the main factors limiting crop production, which provokes a number of changes in plants at physiological, anatomical, biochemical and molecular level. To unravel the various mechanisms underpinning tobacco (Nicotiana tabacum L.) drought stress tolerance, we conducted a comprehensive physiological, anatomical, biochemical and transcriptome analyses of three tobacco cultivars (i.e., HongHuaDaJinYuan (H), NC55 (N) and Yun Yan-100 (Y)) seedlings that had been exposed to drought stress. As a result, H maintained higher growth in term of less reduction in plant fresh weight,
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Shkidyuk, M. V., T. A. Don, and O. K. Bedritskaya. "Complex estimation system for smokeless nicotine containing products." Proceedings of the Voronezh State University of Engineering Technologies 83, no. 1 (2021): 179–86. http://dx.doi.org/10.20914/2310-1202-2021-1-179-186.

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Smokeless nicotine containing products are very diverse and offered in flavored tobacco/non tobacco forms, packed in portioned sachets of different mass, dimensions, and colors, with different nicotine content. In RF of chewing tobacco is regulated by Federal law № 268, sucking tobacco (snus) is prohibited for wholesale and retail trade according to FL № 456. Federal law № 303 equates consuming of non tobacco nicotine containing products for chewing and sucking to tobacco consumption. Absence of regulations for nicotine containing products with similar package, but different in composition and
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Yang, Yongfeng, Zhixiao Yang, Shizhou Yu, and Hongli Chen. "Organic Acids Exuded From Roots Increase the Available Potassium Content in the Rhizosphere Soil: A Rhizobag Experiment in Nicotiana tabacum." HortScience 54, no. 1 (2019): 23–27. http://dx.doi.org/10.21273/hortsci13569-18.

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Organic acid secretion from higher plant roots into the rhizosphere soil plays an important role in nutrient acquisition and metal detoxification; however, their precise functions and the related mechanisms in abiotic stress tolerance remain poorly understood. Tobacco is an important crop plant, so thoroughly elucidating these factors in tobacco is of high priority. In the present study, the activation effect on soil potassium (K), contents of exuded organic acids, and physiological changes in the roots of various tobacco varieties under both normal K supply and K-deficiency stress were invest
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Song, Weiling, Jun Xue, Xuehui Wu, and Jiali He. "Effect and mechanism of Donepezil hydrochloride on Alzheimer’s disease." Discussion of Clinical Cases 10, no. 4 (2024): 21. http://dx.doi.org/10.5430/dcc.v10n4p21.

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Objective: To explore the effect and mechanism of donepezil hydrochloride on Alzheimer’s disease (AD).Methods: Thirty-six 3-month-old SD rats were selected as the research subjects and randomly divided into a normal control (NC) group and a model group. The model group was given continuous intraperitoneal injection of D-galactose solution (120 mg/kg/d) combined with aluminum trichloride (10 mg/kg/d) by gavage for 60 days. Morris water maze test was conducted to test the learning and memory abilities of the rats, and AD rats were selected. After modeling, AD rats were divided into a normal sali
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Luis de Menezes, Edson, та Risely Ferraz-Almeida. "𝘚𝘰𝘳𝘨𝘩𝘶𝘮 𝘴𝘶𝘥𝘢𝘯𝘦𝘯𝘴𝘦 AS COVER CROP AND BIOLOGICAL PRODUCTS ON INCIDENCE OF 𝘚𝘤𝘭𝘦𝘳𝘰𝘵𝘪𝘯𝘪𝘢 𝘴𝘤𝘭𝘦𝘳𝘰𝘵𝘪𝘰𝘳𝘶𝘮 AND YIELD OF TOBACCO". BRAZILIAN JOURNAL OF AGRICULTURE - Revista de Agricultura 96, № 3 (2021): 538–48. http://dx.doi.org/10.37856/bja.v96i3.4286.

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Brazil is the world's second largest producer of tobacco (Nicotiana tabacum) with part of its production concentrated in Santa Catarina. The incidence of Sclerotinia sclerotiorum in tobacco areas has promoted a decrease in productivity, and control alternatives are needed due to the limited use of agrochemicals for the crop. With the hypothesis that the sudan grass (Sorghum sudanense) and Trichoderma harzianum reduce the attack of S. sclerotiorum in tobacco crops on the coast of Santa Catarina; the objective here was to test the incidence of S. sclerotiorum and the use of sudan grass associate
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Xu, Haizhao, Jinpeng Yan, Yan Qin, et al. "Effect of Different Forms of Selenium on the Physiological Response and the Cadmium Uptake by Rice under Cadmium Stress." International Journal of Environmental Research and Public Health 17, no. 19 (2020): 6991. http://dx.doi.org/10.3390/ijerph17196991.

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Cadmium (Cd) is a pollutant toxic to plants and a potential threat to human health. Selenium (Se), though not essential for plants, has beneficial effects on plants under abiotic stress. A hydroponic experiment was conducted to investigate the impact of different forms of Se (Nano-Se, selenite, selenate, and SeMet) on accumulation, subcellular distribution, and chemical forms of Cd, as well as oxidative stress in rice seedlings. Cd (20 μmol·L−1) treatment significantly decreased biomass accumulation and chlorophyll content. The application of all Se forms, except selenate, mitigated the advers
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Dasari, Krishna, Jorge A. Alfaro-Murillo, and Jeffrey P. Townsend. "Abstract A006: Differential therapeutic vulnerabilities and opportunities for smokers and never-smokers based on physiological and adaptive landscapes of lung adenocarcinoma." Cancer Research 85, no. 5_Supplement (2025): A006. https://doi.org/10.1158/1538-7445.genfunc25-a006.

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Abstract Tobacco smoke both has a somatic mutagenic effect and also alters the physiology and microenvironment within the lung. Physiological effects likely influence the extent to which mutations confer proliferative or survival advantages underlying oncogenesis. However, the contributions of these mutagenic and physiological effects to oncogenesis have not previously been quantified. Because the efficacy of such therapies is dependent on the adaptive benefit conferred by the targeted mutations, this quantification is crucial for the development, testing, and application of targeted therapeut
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Houlong, Jiang, Tian Fengjin, Wang Daibin, et al. "The effect of applying different amounts of nitrogen to tobacco seedlings on their growth and physiological characteristics." Australian Journal of Crop Science 11, no. 1 (2017): 76–82. http://dx.doi.org/10.21475/ajcs.2017.11.01.262.

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Breygina, Maria, Dmitry Kochkin, Alexander Voronkov, Tatiana Ivanova, Ksenia Babushkina, and Ekaterina Klimenko. "Plant Hormone and Fatty Acid Screening of Nicotiana tabacum and Lilium longiflorum Stigma Exudates." Biomolecules 13, no. 9 (2023): 1313. http://dx.doi.org/10.3390/biom13091313.

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Pollen germination in vivo on wet stigmas is assisted by the receptive fluid—stigma exudate. Its exact composition is still unknown because only some components have been studied. For the first time, hormonal screening was carried out, and the fatty acid (FA) composition of lipid-rich (Nicotiana tabacum) and sugar-rich (Lilium longiflorum) exudates was studied. Screening of exudate for the presence of plant hormones using HPLC-MS revealed abscisic acid (ABA) in tobacco stigma exudate at the two stages of development, at pre-maturity and in mature stigmas awaiting pollination, increasing at the
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Elwan, Hamada, Mostafa Abdelhakeam, Sally El-Shafei, et al. "Efficacy of Dietary Supplementation with Capsicum Annum L on Performance, Hematology, Blood Biochemistry and Hepatic Antioxidant Status of Growing Rabbits." Animals 10, no. 11 (2020): 2045. http://dx.doi.org/10.3390/ani10112045.

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Animals fed with a high amount of a wide range of antioxidants in their diet are significantly protected against oxidative stress. Powerful antioxidant substances such as vitamin E, vitamin C, and carotenoids are present naturally in red-hot pepper (RHP). This study hypothesized that using RHP may provide protection against oxidative stress and enhance animal physiological responses. Thus, this study aimed to investigate the effect of feeding New Zealand white rabbits with RHP-supplemented diets on their physiological and biochemical responses. New Zealand White rabbits (age = 6 weeks, n = 48)
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Koryagina, N. A., A. N. Zhigulev, A. N. Zabotina, R. O. Dreval, and K. Y. Muravyeva. "Socio-economic modeling of the effect of smokers’ transition to smokeless technologies." Clinician 16, no. 3 (2023): 34–47. http://dx.doi.org/10.17650/1818-8338-2022-16-3-k672.

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Research objective: Quantitative estimation of social-demographic and social-economic impact of the switch of traditional cigarettes smoking to modified risk tobacco products consumption, based on effect upon smoking-related mortality and diseases rates.Methods. Target group – consumers of smoking tobacco: conventional cigarettes (CC) and modified risk tobacco products (MRTP). Base of calculations – analysis of available time series for: CC and MRTP consumption, life expectancy and healthy life expectancy coefficients, statistics on smoking-related mortality and diseases rates, including data
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Wei, Kesu, Jiayi Tang, Lei Yang, et al. "Preharvest Application of Exogenous 2,4-Epibrassinolide and Melatonin Enhances the Maturity and Flue-Cured Quality of Tobacco Leaves." Plants 13, no. 23 (2024): 3266. http://dx.doi.org/10.3390/plants13233266.

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Tobacco (Nicotiana tabacum) is a globally cultivated crop, with its quality closely associated with the color and chemical composition of cured tobacco leaves. In this experiment, the effects of spraying exogenous 2, 4-epibrassinolide (EBR) and melatonin (MT) on the development of tobacco leaves at maturity stage and the quality after curing were investigated. Both EBR and MT treatments significantly enhanced the appearance quality of tobacco leaves at the stem-drying stage. Following preharvest applications, the sugar-to-alkali ratio and potassium content increased, while the contents of star
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Lima, Yasmin Chagas, Ana Raquel Lopes Soares de Almeida, Adelia Vitória Domingos Pontes, Oriel Herrera Bonilla, and Eliseu Marlônio Pereira de Lucena. "Germination performance and vigor of tobacco seeds coated with a chitosan-based bioproduct." Research, Society and Development 11, no. 15 (2022): e158111537064. http://dx.doi.org/10.33448/rsd-v11i15.37064.

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The biopolymer coating use on seeds has aroused the interest of the agricultural sector due to its low cost, reduction of impacts on the environment and improvements in productivity and yield of major crops, being chitosan an important polymer for application in seeds. Considering this knowledge, the present study aimed to evaluate the application effect of a bioproduct based on chitosan, from the parameters of physiological quality, vigor, and biochemistry in tobacco seeds. Seeds of the Virginia variety were submitted to treatments: 0.0 (witness); 0.5; 1; 2.5; 5; and 10% were used to obtain f
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Wang, Tianci, Zikun Jia, Canghai An, et al. "The Protective Effect of Auricularia cornea var. Li. Polysaccharide on Alcoholic Liver Disease and Its Effect on Intestinal Microbiota." Molecules 28, no. 24 (2023): 8003. http://dx.doi.org/10.3390/molecules28248003.

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This study’s objective was to examine the protective effect and mechanism of a novel polysaccharide (AYP) from Auricularia cornea var. Li. on alcoholic liver disease in mice. AYP was extracted from the fruiting bodies of Auricularia cornea var. Li. by enzymatic extraction and purified by DEAE-52 and Sephacryl S-400. Structural features were determined using high-performance liquid chromatography, ion exchange chromatography and Fourier-transform infrared analysis. Additionally, alcoholic liver disease (ALD) mice were established to explore the hepatoprotective activity of AYP (50, 100 and 200
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Eremeyshvili, Avtandil V., and Victoria V. Kazakova. "Effect of smoking on heavy metal content in biosubstrates in 25–60 years males." Hygiene and sanitation 102, no. 6 (2023): 601–4. http://dx.doi.org/10.47470/0016-9900-2023-102-6-601-604.

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Introduction. Tobacco smoking can be designate as one of the most common world problems that negatively affects on the functional activity of the human body.
 The purpose of the study is to determine the degree of influence of tobacco smoking on the content of heavy metals (Zn, Cu, Pb, Cd) in biosubstrates of employees with different smoking experience in the absence of significant anthropogenic and man-made burden in the place of residence.
 Materials and methods. This study is experimental. To investigate the state of health of the population, hair samples were taken from 25 to 60
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Qin, Li-Jun, Dan Zhao, Yi Zhang, and De-Gang Zhao. "Selectable marker-free co-expression of Nicotiana rustica CN and Nicotiana tabacum HAK1 genes improves resistance to tobacco mosaic virus in tobacco." Functional Plant Biology 42, no. 8 (2015): 802. http://dx.doi.org/10.1071/fp14356.

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The viral disease caused by tobacco mosaic virus (TMV) is the most prevalent viral disease in many tobacco production areas. A breeding strategy based on resistance genes is an effective method for improving TMV resistance in tobacco. Also, the physiological status of plants is also critical to disease resistance improvement. Potassium ion is one of the most abundant inorganic nutrients in plant cells, and mediates plant responses to abiotic and biotic stresses. Improving K+ content in soil by fertilising can enhance diseases resistance of crops. However, the K+ absorption in plants depends mo
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Zhang, Y., and D. M. Roberts. "Expression of soybean nodulin 26 in transgenic tobacco. Targeting to the vacuolar membrane and effects on floral and seed development." Molecular Biology of the Cell 6, no. 1 (1995): 109–17. http://dx.doi.org/10.1091/mbc.6.1.109.

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Nodulin 26 is an integral membrane protein of the symbiosome membrane of nitrogen-fixing soybean nodules. We expressed a nodulin 26 cDNA in transgenic tobacco (TN26 tobacco) under the control of the cauliflower mosaic virus 35S promoter to study subcellular targeting and the physiological effect(s) of its expression. Based on Northern and Western blots, the expression of nodulin 26 mRNA and protein in transgenic plants is high in apical shoot sections, flowers, and stems, low in mature leaves, and absent in roots. Western blot analysis revealed high levels of transgenic nodulin 26 protein in t
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Petkova, Mariana, Slaveya Petrova, Velichka Spasova-Apostolova, and Mladen Naydenov. "Tobacco Plant Growth-Promoting and Antifungal Activities of Three Endophytic Yeast Strains." Plants 11, no. 6 (2022): 751. http://dx.doi.org/10.3390/plants11060751.

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In this research, the biosynthetic and biocontrol potential of endophytic yeast to improve the growth and development of tobacco has been elucidated. Three yeast strains were enriched and isolated from different plant tissues. Partial sequence analysis of ITS5-5.8-ITS4 region of the nuclear ribosomal DNA with universal primers identified YD5, YE1, and YSW1 as Saccharomyces cerevisiae (S. cerevisiae), Zygosaccharomyces bailii (Z. bailii), and Saccharomyces kudriavzevii (S. kudriavzevii), respectively. When cultivated in a medium supplemented with 0.1% L-tryptophan, isolated yeast strains produc
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Zhang, Ziqiang, Jingyi Xu, Xin Zhang, et al. "Protective Effect of SeMet on Liver Injury Induced by Ochratoxin A in Rabbits." Toxins 14, no. 9 (2022): 628. http://dx.doi.org/10.3390/toxins14090628.

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Ochratoxin A (OTA) is second only to aflatoxin in toxicity among mycotoxins. Recent studies have shown that selenomethionine (SeMet) has a protective effect on mycotoxin-induced toxicity. The purpose of this study was to investigate the protective effect and mechanism of SeMet on OTA-induced liver injury in rabbits. Sixty 35-day-old rabbits with similar body weight were randomly divided into five groups: control group, OTA group (0.2 mg/kg OTA), OTA + 0.2 mg/kg SeMet group, OTA + 0.4 mg/kg SeMet group and OTA + 0.6 mg/kg SeMet group. Rabbits were fed different doses of the SeMet diet for 21 d,
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Ismaeil, A1* Jankowski PM1 Riffat FB2 Asmadi M3 Juhasz-Böss I4 Hammadeh ME1 4. Amor H1 4. "Impact of Tobacco and Recreational Cannabis Smoking on Male Reproductive Health: A Comparative Look at Sperm Parameters, Chromatin Integrity and Oxidative Damage." International Clinical and Medical Case Reports Journal 3, no. 6 (2024): 1–26. https://doi.org/10.5281/zenodo.11519761.

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Male infertility, accounting for approximately 50% of infertile couples' cases <sup>[1]</sup>, and is gradually leading to depression and other psychological outcomes, and this might be potential signs of serious future consequences. The negative impact of tobacco smoking on a wide range of physiological functions is well-established. Moreover, the consumption of tobacco and cannabis poses a growing risk to male reproductive health. Numerous studies over recent decades have indicated a correlation between smoking tobacco or cannabis and a decline in sperm quality, potentially leading to male i
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W. Al-Bideri, Adnan, Alaauddin S.M.Al-sallami, and Shaymaa H.Alsaaedi. "Protective Role of Pomegranate Peel (Punica granatum L) against Thioacetamide-Induced cirrhosis in a Rat Model." Al-Kufa University Journal for Biology 9, no. 2 (2017): 74–83. http://dx.doi.org/10.36320/ajb/v9.i2.7592.

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This study was designed to determine the effects of pomegranate peel on various antioxidiants measurements in liver cirrhosis of rats induced by thioacetamide.Fifty-seven male rats aged 13–15 weeks were randomly divided into 15 categories containing 5 rats per category, and were treated with either TAA, PP, or PP plus TAA or Selenium plus TAA or administered with 0.9% physiological saline solution as a control. The hepatoprotective effect of herbs was evaluated by measuring levels of antioxidiant marker enzymes such as Glutathione Peroxidase (GSH-Px) and Superoxide Dismutase (SOD) and measurem
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Freitas, Cleverson D. T. de, Beatriz C. Nishi, Camila T. M. do Nascimento, et al. "Characterization of Three Osmotin-Like Proteins from Plumeria rubra and Prospection for Adiponectin Peptidomimetics." Protein & Peptide Letters 27, no. 7 (2020): 593–603. http://dx.doi.org/10.2174/0929866527666200129154357.

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Background: Osmotin-Like Proteins (OLPs) have been purified and characterized from different plant tissues, including latex fluids. Besides its defensive role, tobacco osmotin seems to induce adiponectin-like physiological effects, acting as an agonist. However, molecular information about this agonistic effect on adiponectin receptors has been poorly exploited and other osmotins have not been investigated yet. Objective and Methods: The present study involved the characterization of three OLPs from Plumeria rubra latex and molecular docking studies to evaluate the interaction between them and
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