Rozprawy doktorskie na temat „Thiol binding”
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Tong, Grace C. "Characterization of Cys-34 in serum albumin". Columbus, Ohio : Ohio State University, 2003. http://rave.ohiolink.edu/etdc/view?acc%5fnum=osu1061473878.
Pełny tekst źródłaTitle from first page of PDF file. Document formatted into pages; contains xxiii, 325 p.; also contains graphics (some col.). Includes abstract and vita. Advisor: Gary E. Means, Dept. of Biochemistry. Includes bibliographical references (p. 206-225).
Rossato, Mateus Fortes. "Eriodictiol: um flavonóide antagonista do receptor trpv1 com atividade antioxidante". Universidade Federal de Santa Maria, 2010. http://repositorio.ufsm.br/handle/1/11134.
Pełny tekst źródłaThe transient receptor potential vanilloid 1 (TRPV1) is a calcium permeable channel responsible for the transduction and modulation of acute and chronic pain signaling, being a potential target for treatment of different pain disorders. In spite of that, AMG517, a TRPV1 antagonist, presents several clinical limitations, such as the development of severe hypertermia. The aim of this study was to investigate the possible interaction of the flavonoid eriodictyol with the TRPV1 receptor and its putative antinociceptive and hyperthermic effect. Eriodictyol was able to displace the [3H]-resiniferatoxin binding (IC50 = 47 (21 - 119) nM) and to inhibit the calcium influx mediated by capsaicin (IC50 = 44 (16 125) nM), suggesting that eriodictyol acts as a TRPV1 antagonist. Moreover, eriodictyol induces antinociception in the intraplantar capsaicin test, with maximal effect of 49±10 and 64±4% of inhibition for oral (ED50 = 2 (1-5) mg/kg) and intrathecal (ED50 = 2 (1-3) nmol/site) routes, respectively. Concomitantly, eriodictyol did not induce any alteration on body temperature or locomotor activity. Orally administered eriodictyol (4.5 mg/kg) prevented the nociception induced by intrathecal injection of capsaicin (72±6% of inhibition), the non-protein thiol loss and the 3-nitrotyronise (3-NT) formation induced by capsaicin in spinal cord. Eriodictyol (4.5 mg/kg, p.o.) also reduced the thermal hyperalgesia (100% of inhibition) and mechanical allodynia (62±9% of inhibition) elicited by complete Freund s adjuvant (CFA) paw injection. In conclusion, Eriodictyol acts as an antagonist of TRPV1 receptor and an antioxidant, inducing antinociception without some side effects and limitations expected for TRPV1 antagonists, as hyperthermia.
O receptor de potencial transiente vanilóide 1 (TRPV1) é um canal iônico permeável a cátions ativado por uma série de estímulos nocivos, como calor, acidificação e agentes irritantes como a capsaicina. Este receptor é responsável pela detecção e transmissão da dor aguda e crônica. Devido a isso, substâncias que modulem a atividade deste receptor apresentam um potencial clínico para o tratamento da dor. Assim, este trabalho objetiva a possível interação do flavonóide eriodictiol com o receptor TRPV1. Inicialmente, observamos que o eriodictiol foi capaz de deslocar o radioligante [3H]-resiniferatoxina, em ensaio de união específica, do receptor TRPV1 com uma concentração inibitória 50% (IC50) de 46.9 (20.70 - 118.9) nM. Ao mesmo tempo, o eriodictiol também inibiu o influxo de cálcio estimulado por capsaicina com IC50 de 44,4 (15,6 125,1) nM, sugerindo que este aja como um antagonista do receptor. Além disso, também observamos que o eriodictiol induz antinocicepção no teste da capsaicina intraplantar com efeito máximo de 49,0±10.5 e 63,9±4.0 % de inibição máxima para o tratamento oral e intratecal, respectivamente, e com uma dose efetiva 50% (DE50) de 2,4 (1,0 5,5) mg/kg 2,2 (1,6 2,9) nmol/site, respectivamente. Além disso, não observamos alterações na atividade locomotora ou temperatura corporal dos animais. A administração oral de eriodictiol também foi capaz de prevenir a nocicepção induzida por capsaicina intratecal (71,7±5,7 % de inibição). Ao mesmo tempo, o eriodictiol também aboliu a hiperalgesia térmica e reduziu a alodínia mecânica (62,4±9,2 %) induzidas por adjuvante completo de Freund. Da mesma forma, o eriodictiol também preveniu totalmente a diminuição de tiois não protéicos e formação de 3-nitrotirosina (3-NT) espinhais induzidas por capsaicina, ao passo que apresentou atividade antioxidante direta no texto de neutralização do radical ABTS. Em conclusão, nossos resultados mostram que o eriodictiol age como um antagonista do receptor TRPV1, com atividade antioxidante, induzindo antinocicepção sem os efeitos colaterais e limitações esperados para antagonistas do receptor TRPV1.
Cafe, Peter F. "Towards reliable contacts of molecular electronic devices to gold electrodes". Thesis, The University of Sydney, 2008. http://hdl.handle.net/2123/3870.
Pełny tekst źródłaCafe, Peter F. "Towards reliable contacts of molecular electronic devices to gold electrodes". University of Sydney, 2008. http://hdl.handle.net/2123/3870.
Pełny tekst źródłaSYNOPSIS OF THIS THESIS The aim of this thesis is to more fully understand and explain the binding mechanism of organic molecules to the Au(111) surface and to explore the conduction of such molecules. It consists of five discreet chapters connected to each other by the central theme of “The Single Molecule Device: Conductance and Binding”. There is a deliberate concentration on azine linkers, in particular those with a 1,10-phenanthroline-type bidentate configuration at each end. This linker unit is called a “molecular alligator clip” and is investigated as an alternative to the thiol linker unit more commonly used. Chapter 1 places the work in the broad context of Molecular Electronics and establishes the need for this research. In Chapter 2 the multiple break-junction technique (using a Scanning Tunnelling Microscope or similar device) was used to investigate the conductance of various molecules with azine linkers. A major finding of those experiments is that solvent interactions are a key factor in the conductance signal of particular molecules. Some solvents interfere with the molecule’s interaction with and attachment to the gold electrodes. One indicator of the degree of this interference is the extent of the enhancement or otherwise of the gold quantized conduction peak at 1.0 G0. Below 1.0 G0 a broad range for which the molecule enhances conduction indicates that solvent interactions contribute to a variety of structures which could bridge the electrodes, each with their own specific conductance value. The use of histograms with a Log10 scale for conductance proved useful for observing broad range features. vi Another factor which affects the conductance signal is the geometric alignment of the molecule (or the molecule-solvent structure) to the gold electrode, and the molecular alignment is explored in Chapters 3 for 1,10-phenanthroline (PHEN) and Chapter 4 for thiols. In Chapter 3 STM images, electrochemistry, and Density Functional Theory (DFT) are used to determine 1,10-phenanthroline (PHEN) structures on the Au(111) surface. It is established that PHEN binds in two modes, a physisorbed state and a chemisorbed state. The chemisorbed state is more stable and involves the extraction of gold from the bulk to form adatom-PHEN entities which are highly mobile on the gold surface. Surface pitting is viewed as evidential of the formation of the adatom-molecule entities. DFT calculations in this chapter were performed by Ante Bilic and Jeffery Reimers. The conclusions to Chapter 3 implicate the adatom as a binding mode of thiols to gold and this is explored in Chapter 4 by a timely review of nascent research in the field. The adatom motif is identified as the major binding structure for thiol terminated molecules to gold, using the explanation of surface pitting in Chapter 3 as major evidence and substantiated by emergent literature, both experimental and theoretical. Furthermore, the effect of this binding mode on conductance is explored and structures relevant to the break-junction experiment of Chapter 2 are identified and their conductance values compared. Finally, as a result of researching extensive reports of molecular conductance values, and having attempted the same, a simple method for predicting the conductance of single molecules is presented based upon the tunneling conductance formula.
Bernhard, Max [Verfasser], Gerhard [Akademischer Betreuer] Thiel i Bodo [Akademischer Betreuer] Laube. "Binding Proteins and Receptor Binding Domains as Sensor Elements for Biological and Artificial Nanopores / Max Bernhard ; Gerhard Thiel, Bodo Laube". Darmstadt : Universitäts- und Landesbibliothek, 2021. http://d-nb.info/1236344782/34.
Pełny tekst źródłaStröh, Luisa Johanna [Verfasser], i Thilo [Akademischer Betreuer] Stehle. "Structural Analysis and Glycan Receptor Binding Specificities of Human Polyomaviruses / Luisa Johanna Ströh ; Betreuer: Thilo Stehle". Tübingen : Universitätsbibliothek Tübingen, 2017. http://d-nb.info/119946306X/34.
Pełny tekst źródłaSchönrock, Michael [Verfasser], Bodo [Akademischer Betreuer] Laube i Gerhard [Akademischer Betreuer] Thiel. "Modular design of ionotropic glutamate receptors: Coupling of a viral K+-channel with a glutamate-binding domain / Michael Schönrock ; Bodo Laube, Gerhard Thiel". Darmstadt : Universitäts- und Landesbibliothek Darmstadt, 2019. http://d-nb.info/1182537499/34.
Pełny tekst źródłaYang, Chao. "Syntheses and Bioactivities of Targeted and Conformationally Restrained Paclitaxel and Discodermolide Analogs". Diss., Virginia Tech, 2008. http://hdl.handle.net/10919/28942.
Pełny tekst źródłaPh. D.
Hetzke, Thilo [Verfasser], Thomas [Akademischer Betreuer] Prisner, Thomas [Gutachter] Prisner i Josef [Gutachter] Wachtveitl. "PELDOR and hyperfine spectroscopy as complementary tools to investigate a tetracycline-binding RNA aptamer / Thilo Hetzke ; Gutachter: Thomas Prisner, Josef Wachtveitl ; Betreuer: Thomas Prisner". Frankfurt am Main : Universitätsbibliothek Johann Christian Senckenberg, 2020. http://d-nb.info/1212930312/34.
Pełny tekst źródłaLiu, Changhui. "Syntheses and Bioactivities of Targeted and Conformationally Restrained Taxol Analogs". Diss., Virginia Tech, 2004. http://hdl.handle.net/10919/11186.
Pełny tekst źródłaPh. D.
Leeder, Wolf-Matthias [Verfasser], H. Ulrich [Akademischer Betreuer] Göringer i Gerhard [Akademischer Betreuer] Thiel. "Monitoring the Structural Changes of pre-edited mRNAs upon Editosome Binding - Evidence for the Evolutionary Origin of RNA-Editing / Wolf-Matthias Leeder. Betreuer: H. Ulrich Göringer ; Gerhard Thiel". Darmstadt : Universitäts- und Landesbibliothek Darmstadt, 2016. http://d-nb.info/1112269797/34.
Pełny tekst źródłaFried, Dorothee [Verfasser], Beatrix [Akademischer Betreuer] Süß, Gerhard [Akademischer Betreuer] Thiel i Harald [Akademischer Betreuer] Burkhardt. "Molekulare Analyse der Interaktion der Disintegrin-Metalloproteinase ADAM15 mit der Fokalen Adhasionskinase und dem Poly(A)-Binding Protein in osteoarthrotischen Chondrozyten / Dorothee Fried ; Beatrix Süß, Gerhard Thiel, Harald Burkhardt". Darmstadt : Universitäts- und Landesbibliothek Darmstadt, 2018. http://d-nb.info/1161529519/34.
Pełny tekst źródłaBaumgärtel, Thomas. "Binding and characterization of fluorescent nano-aggregates on structured surfaces". Doctoral thesis, Universitätsbibliothek Chemnitz, 2012. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-qucosa-91552.
Pełny tekst źródłaGoldstein, Beth Erlichman. "Single channel analysis of thiol binding to a putative site of alcohol action on the glycine receptor". 2009. http://hdl.handle.net/2152/6666.
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林俊毅. "The fabrication of Iron Oxide magnetic nanoparticles and the application to improve the binding efficiency of the IgG and Thiol SAMs". Thesis, 2006. http://ndltd.ncl.edu.tw/handle/27005461973066812588.
Pełny tekst źródłaMcKnight-Whitford, Anthony Nicholai. "Arsenic Binding to Thiols and Applications to Electrospray Mass Spectrometry Detection". Phd thesis, 2010. http://hdl.handle.net/10048/1128.
Pełny tekst źródłaOgunbayo, T. B., i Tebello Nyokong. "Synthesis and Pd(II) binding studies of octasubstituted alkyl thio derivatised phthalocyanines". 2009. http://hdl.handle.net/10962/d1004170.
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