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Artykuły w czasopismach na temat „Thiochromenes”

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Data publikacji: 6 września 2023

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1

Luque-Agudo, V., J. Albarrán-Velo, J. G. Fernández-Bolaños, O. López, M. E. Light, J. M. Padrón, I. Lagunes, E. Román, J. A. Serrano i M. V. Gil. "Synthesis and antiproliferative activity of sulfa-Michael adducts and thiochromenes derived from carbohydrates". New Journal of Chemistry 41, nr 8 (2017): 3154–62. http://dx.doi.org/10.1039/c6nj03940e.

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2

Ortiz, Cristian, Fernando Echeverri, Sara Robledo, Daniela Lanari, Massimo Curini, Wiston Quiñones i Esteban Vargas. "Synthesis and Evaluation of Antileishmanial and Cytotoxic Activity of Benzothiopyrane Derivatives". Molecules 25, nr 4 (12.02.2020): 800. http://dx.doi.org/10.3390/molecules25040800.

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In continuation of our efforts to identify promising antileishmanial agents based on the chroman scaffold, we synthesized several substituted 2H-thiochroman derivatives, including thiochromenes, thichromanones and hydrazones substituted in C-2 or C-3 with carbonyl or carboxyl groups. Thirty-two compounds were thus obtained, characterized, and evaluated against intracellular amastigotes of Leishmania (V) panamensis. Twelve compounds were active, with EC50 values lower than 40 µM, but only four compounds displayed the highest antileishmanial activity, with EC50 values below 10 µM; these all compounds possess a good Selectivity Index > 2.6. Although two active compounds were thiochromenes, a clear structure-activity relationship was not detected since each active compound has a different substitution pattern.
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3

An, Yi, Fang Zhang, Guangfen Du, Zhihua Cai i Lin He. "Construction of 6H-benzo[c]thiochromenes via a tandem reaction of arynes with thionoesters". Organic Chemistry Frontiers 8, nr 24 (2021): 6979–84. http://dx.doi.org/10.1039/d1qo01177d.

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4

Chanda, Rupsa, Abhishek Kar, Aniruddha Das, Baitan Chakraborty i Umasish Jana. "Iron-catalyzed carboarylation of alkynes via activation of π-activated alcohols: rapid synthesis of substituted benzofused six-membered heterocycles". Organic & Biomolecular Chemistry 19, nr 23 (2021): 5155–60. http://dx.doi.org/10.1039/d1ob00488c.

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An iron(iii) catalyzed carboarylation of alkynes is reported for the synthesis of highly substituted 1,2-dihydroquinolines, quinolines, 2H-chromenes, and 2H-thiochromenes under mild reaction conditions.
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5

Wang, W., H. Li, J. Wang i L. Zu. "Organocatalytic One-Pot Synthesis of Chiral Thiochromenes". Synfacts 2006, nr 10 (wrzesień 2006): 1065. http://dx.doi.org/10.1055/s-2006-949371.

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6

Markova, L. I., i V. G. Kharchenko. "Specific reactions of 5-oxotetrahydro-4H-thiochromenes with Grignard reagents". Chemistry of Heterocyclic Compounds 30, nr 5 (maj 1994): 537–39. http://dx.doi.org/10.1007/bf01169828.

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7

Gabbutt, Christopher D., John D. Hepworth i B. Mark Heron. "Reactions of some 2H-Chromenes and 2H-Thiochromenes with triazolinediones". Tetrahedron 51, nr 48 (listopad 1995): 13277–90. http://dx.doi.org/10.1016/0040-4020(95)00874-8.

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8

Bhanja, Chittaranjan, Satyaban Jena, Sabita Nayak i Seetaram Mohapatra. "Organocatalytic tandem Michael addition reactions: A powerful access to the enantioselective synthesis of functionalized chromenes, thiochromenes and 1,2-dihydroquinolines". Beilstein Journal of Organic Chemistry 8 (4.10.2012): 1668–94. http://dx.doi.org/10.3762/bjoc.8.191.

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Enantioselective organocatalysis has become a field of central importance within asymmetric chemical synthesis and appears to be efficient approach toward the construction of complex chiral molecules from simple achiral materials in one-pot transformations under mild conditions with high stereocontrol. This review addresses the most significant synthetic methods reported on chiral-amine-catalyzed tandem Michael conjugate addition of heteroatom-centered nucleophiles to α,β-unsaturated compounds followed by cyclization reactions for the enantioselective construction of functionalized chiral chromenes, thiochromenes and 1,2-dihydroquinolines in optically enriched forms found in a myriad of bioactive natural products and synthetic compounds.
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9

Tércio, J., B. Ferreira, V. Catani i J. V. Comasseto. "Synthesis of 2,2-Dimethyl-2H-thiochromenes, the Sulfur Analogs of Precocenes". Synthesis 1987, nr 02 (1987): 149–53. http://dx.doi.org/10.1055/s-1987-27866.

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10

Voskressensky, Leonid G., Ekaterina A. Sokolova, Alexey A. Festa i Alexey V. Varlamov. "A novel domino condensation–intramolecular nucleophilic cyclization approach towards annulated thiochromenes". Tetrahedron Letters 54, nr 38 (wrzesień 2013): 5172–73. http://dx.doi.org/10.1016/j.tetlet.2013.07.040.

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11

Ahlemeyer, Nicholas A., i Vladimir B. Birman. "Asymmetric Catalytic Synthesis of Thiochromenes via an Acyl Transfer-Initiated Cascade". Organic Letters 18, nr 14 (6.07.2016): 3454–57. http://dx.doi.org/10.1021/acs.orglett.6b01639.

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12

Wang, Wei, Hao Li, Jian Wang i Liansuo Zu. "Enantioselective Organocatalytic Tandem Michael−Aldol Reactions: One-Pot Synthesis of Chiral Thiochromenes". Journal of the American Chemical Society 128, nr 32 (sierpień 2006): 10354–55. http://dx.doi.org/10.1021/ja063328m.

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13

Gabbutt, Christopher D., David J. Hartley, John D. Hepworth, B. Mark Heron, Magan Kanjia i M. Moshfiqur Rahman. "Synthesis and reactivity of some 4-bromo- 2H-chromenes and 2H-thiochromenes". Tetrahedron 50, nr 8 (luty 1994): 2507–22. http://dx.doi.org/10.1016/s0040-4020(01)86967-2.

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14

GABBUTT, C. D., J. D. HEPWORTH i B. M. HERON. "ChemInform Abstract: Reactions of Some 2H-Chromenes and 2H-Thiochromenes with Triazolinediones." ChemInform 27, nr 13 (12.08.2010): no. http://dx.doi.org/10.1002/chin.199613145.

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15

Muthupandi, Pandi, Nallappan Sundaravelu i Govindasamy Sekar. "Domino Synthesis of Thiochromenes through Cu-Catalyzed Incorporation of Sulfur Using Xanthate Surrogate". Journal of Organic Chemistry 82, nr 4 (6.02.2017): 1936–42. http://dx.doi.org/10.1021/acs.joc.6b02740.

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16

Markova, L. I., N. G. Korobochkina i V. G. Kharchenko. "Unusual conversion of substituted 5-oxo-5,6,7,8-tetrahydro-4H-thiochromenes with phosphorus pentachloride". Chemistry of Heterocyclic Compounds 35, nr 6 (czerwiec 1999): 746–47. http://dx.doi.org/10.1007/bf02251637.

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17

Choudhury, Abhijnan Ray, i Santanu Mukherjee. "A Catalytic Michael/Horner-Wadsworth-Emmons Cascade Reaction for Enantioselective Synthesis of Thiochromenes". Advanced Synthesis & Catalysis 355, nr 10 (8.07.2013): 1989–95. http://dx.doi.org/10.1002/adsc.201300281.

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18

Voskressensky, Leonid G., Ekaterina A. Sokolova, Alexey A. Festa i Alexey V. Varlamov. "ChemInform Abstract: A Novel Domino Condensation-Intramolecular Nucleophilic Cyclization Approach Towards Annulated Thiochromenes." ChemInform 45, nr 3 (2.01.2014): no. http://dx.doi.org/10.1002/chin.201403181.

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19

Velasco, Noelia, Anisley Suárez, Fernando Martínez-Lara, Manuel Ángel Fernández-Rodríguez, Roberto Sanz i Samuel Suárez-Pantiga. "From Propargylic Alcohols to Substituted Thiochromenes: gem-Disubstituent Effect in Intramolecular Alkyne Iodo/hydroarylation". Journal of Organic Chemistry 86, nr 10 (30.04.2021): 7078–91. http://dx.doi.org/10.1021/acs.joc.1c00333.

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20

MARKOVA, L. I., i V. G. KHARCHENKO. "ChemInform Abstract: Peculiarities in the Reaction of 5-Oxotetrahydro-4H-thiochromenes with Grignard Reagents." ChemInform 26, nr 10 (18.08.2010): no. http://dx.doi.org/10.1002/chin.199510158.

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21

GABBUTT, C. D., D. J. HARTLEY, J. D. HEPWORTH, B. M. HERON, M. KANJIA i M. M. RAHMAN. "ChemInform Abstract: Synthesis and Reactivity of Some 4-Bromo-2H-chromenes and -2H- thiochromenes." ChemInform 25, nr 26 (19.08.2010): no. http://dx.doi.org/10.1002/chin.199426166.

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22

Simlandy, Amit Kumar, i Santanu Mukherjee. "Catalytic Enantioselective Synthesis of 3,4-Unsubstituted Thiochromenes through Sulfa-Michael/Julia–Kocienski Olefination Cascade Reaction". Journal of Organic Chemistry 82, nr 9 (19.04.2017): 4851–58. http://dx.doi.org/10.1021/acs.joc.7b00579.

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23

Markova, L. I., N. G. Korobochkina i V. G. Kharchenko. "ChemInform Abstract: Unusual Conversion of Substituted 5-Oxo-5,6,7,8-tetrahydro-4H-thiochromenes with Phosphorus Pentachloride." ChemInform 31, nr 18 (8.06.2010): no. http://dx.doi.org/10.1002/chin.200018095.

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24

Choudhury, Abhijnan Ray, i Santanu Mukherjee. "ChemInform Abstract: A Catalytic Michael/Horner-Wadsworth-Emmons Cascade Reaction for Enantioselective Synthesis of Thiochromenes." ChemInform 44, nr 50 (21.11.2013): no. http://dx.doi.org/10.1002/chin.201350159.

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25

Cui, Sun-Liang, Jing Wang i Yan-Guang Wang. "Efficient synthesis of 2-imino-1,2-dihydroquinolines and 2-imino-thiochromenes via copper-catalyzed domino reaction". Tetrahedron 64, nr 3 (styczeń 2008): 487–92. http://dx.doi.org/10.1016/j.tet.2007.11.025.

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26

Cha, Myeong Jong, Young Seok Song, Eun‐Gu Han i Kee‐Jung Lee. "Application of the acetate of baylis‐hillman adducts in the synthesis of 3‐carbomethoxy‐2H‐thiochromenes". Journal of Heterocyclic Chemistry 45, nr 1 (styczeń 2008): 235–40. http://dx.doi.org/10.1002/jhet.5570450129.

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27

Liu, Tong, Guanyinsheng Qiu, Qiuping Ding i Jie Wu. "Assembly of 3-(trifluoromethyl)thiochromenes via a regioselective trifluoromethylthioarylation of (3-arylprop-2-ynyl)oxybenzenes with trifluoromethanesulfanylamide". Tetrahedron 72, nr 11 (marzec 2016): 1472–76. http://dx.doi.org/10.1016/j.tet.2016.01.053.

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28

Kinfe, Henok Hadgu, Fanuel Mesfin Mebrahtu, Felix Loka Makolo, Paseka Thendo Moshapo i Mandlenkosi Maxwell Manana. "Stereoselective Synthesis of Thiochromenes via Intramolecular Tandem Thio-Michael Addition of in Situ Generated α,β-Unsaturated Aldehydes". Journal of Organic Chemistry 79, nr 7 (18.03.2014): 3111–18. http://dx.doi.org/10.1021/jo5002164.

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29

Wang, Dan-Jiao, Zhuang Hou, Hang Xu, Ran An, Xin Su i Chun Guo. "Design, synthesis, and biological evaluation of 4-chloro-2H-thiochromenes featuring nitrogen-containing side chains as potent antifungal agents". Bioorganic & Medicinal Chemistry Letters 28, nr 22 (grudzień 2018): 3574–78. http://dx.doi.org/10.1016/j.bmcl.2018.06.035.

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30

Kinfe, Henok Hadgu, Fanuel Mesfin Mebrahtu, Felix Loka Makolo, Paseka Thendo Moshapo i Mandlenkosi Maxwell Manana. "ChemInform Abstract: Stereoselective Synthesis of Thiochromenes via Intramolecular Tandem Thio-Michael Addition of in situ Generated α,β-Unsaturated Aldehydes." ChemInform 45, nr 39 (11.09.2014): no. http://dx.doi.org/10.1002/chin.201439168.

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31

Pham, Chien Thang, Dinh Hung Mac i Thai Thanh Thu Bui. "Crystal structures of 2-(2-bromo-5-fluorophenyl)-8-ethoxy-3-nitro-2H-thiochromene and 2-(2-bromo-5-fluorophenyl)-7-methoxy-3-nitro-2H-thiochromene". Acta Crystallographica Section E Crystallographic Communications 75, nr 11 (31.10.2019): 1783–86. http://dx.doi.org/10.1107/s2056989019014178.

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Two thiochromene compounds containing Br and F atoms, namely 2-(2-bromo-5-fluorophenyl)-8-ethoxy-3-nitro-2H-thiochromene (C17H13BrFNO3S, A) and 2-(2-bromo-5-fluorophenyl)-7-methoxy-3-nitro-2H-thiochromene (C16H11BrFNO3S, B), were prepared via the condensation reaction between 2-mercaptobenzaldehyde and nitrostyrene derivatives. In both compounds, the thiochromene plane is almost perpendicular to the phenyl ring. In the structure of A, molecules are assembled via π–π stacking and C—H...O and C—F...π interactions. In the crystal packing of B, molecules are linked by C—H...F, C—H...O, C—H...π and π–π interactions.
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32

Bhanja, Chittaranjan, Satyaban Jena, Sabita Nayak i Seetaram Mohapatra. "ChemInform Abstract: Organocatalytic Tandem Michael Addition Reactions: A Powerful Access to the Enantioselective Synthesis of Functionalized Chromenes, Thiochromenes and 1,2-Dihydroquinolines". ChemInform 44, nr 12 (14.03.2013): no. http://dx.doi.org/10.1002/chin.201312246.

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33

Barakat, Assem, Mohammad Shahidul Islam, M. Ali, Abdullah Mohammed Al-Majid, Saeed Alshahrani, Abdullah Saleh Alamary, Sammer Yousuf i M. Iqbal Choudhary. "Regio- and Stereoselective Synthesis of a New Series of Spirooxindole Pyrrolidine Grafted Thiochromene Scaffolds as Potential Anticancer Agents". Symmetry 13, nr 8 (4.08.2021): 1426. http://dx.doi.org/10.3390/sym13081426.

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A series of new spiro-heterocycles engrafted spirooxindole/pyrrolidine/thiochromene scaffolds was synthesized by the three-component 1,3-dipolar cycloaddition reactions in a fully controlled regio- and stereo-selective fashion. Condensation of several substituted isatin derivatives with L-proline generated the azomethine ylides which subsequently reacted with chalcones based thiochromene scaffold, and finally afforded the target spiro-compounds. This simple protocol furnished a structurally complex, biologically relevant spiro-heterocycles in good yields through a one-pot process. All synthesized chalcone-based thiochromene, along with the spirooxindole/pyrrolidine/thiochromene scaffolds, were tested for their anticancer activity against four cancer cell lines (PC3, HeLa, MCF-7, and MDA-MB231). Toxicity of these compounds was also evaluated against human fibroblast BJ cell line, and they appeared to be not cytotoxic. For the prostate cancer (PC3) cell line, the most active hybrid, among synthesized series, was compound (7f, IC50 = 8.7 ± 0.7 µM). The most potent spirooxindole/pyrrolidine/thiochromene hybrid against cervical (HeLa) cancer cells was compound (7k, IC50 = 8.4 ± 0.5 µM) having chlorine and p-trifluoromethyl substituents attached to phenyl rings. Finally, against the MCF-7 and MDA-MB231 breast cancer cell lines, compound (7d) was the most active member of this series (IC50 = 7.36 ± 0.37, and 9.44 ± 0.32 µM, respectively).
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34

Roy, Rimi, Soumyadipta Rakshit, Tanmoy Bhowmik, Sagar Khan, Avishek Ghatak i Sanjay Bhar. "Substituted 3-E-Styryl-2H-chromenes and 3-E-Styryl-2H-thiochromenes: Synthesis, Photophysical Studies, Anticancer Activity, and Exploration to Tricyclic Benzopyran Skeleton". Journal of Organic Chemistry 79, nr 14 (7.07.2014): 6603–14. http://dx.doi.org/10.1021/jo5011125.

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35

Usachev, B. I., M. A. Shafeev i V. Ya Sosnovskikh. "2-Trif luoromethyl-4H-thiochromen-4-one and 2-trif luoromethyl-4H-thiochromene-4-thione: Synthesis and reactivities". Russian Chemical Bulletin 55, nr 3 (marzec 2006): 523–28. http://dx.doi.org/10.1007/s11172-006-0286-z.

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36

Roy, Rimi, Soumyadipta Rakshit, Tanmoy Bhowmik, Sagar Khan, Avishek Ghatak i Sanjay Bhar. "ChemInform Abstract: Substituted 3-E-Styryl-2H-chromenes and 3-E-Styryl-2H-thiochromenes: Synthesis, Photophysical Studies, Anticancer Activity, and Exploration to Tricyclic Benzopyran Skeleton." ChemInform 46, nr 2 (19.12.2014): no. http://dx.doi.org/10.1002/chin.201502138.

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37

Sundaravelu, Nallappan, i Govindasamy Sekar. "Cu-Catalyzed one-pot synthesis of thiochromeno-quinolinone and thiochromeno-thioflavone via oxidative double hetero Michael addition using in situ generated nucleophiles". Chemical Communications 56, nr 62 (2020): 8826–29. http://dx.doi.org/10.1039/d0cc03210g.

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A copper catalyzed three-component synthesis of π-conjugated tetracyclic thiochromeno-quinolinone and thiochromeno-thioflavone was established via oxidative double hetero Michael addition using in situ generated nucleophiles.
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38

Zhu, Yong-Ming, Fang-Ling Zhang, Zhen-Bang Chen, Kui Liu, Qing Yuan i Qing Jiang. "Carbonylative Synthesis of Thiochromenones via Palladium-Catalyzed tert-Butyl Isocyanide Insertion". Synlett 29, nr 05 (23.01.2018): 621–26. http://dx.doi.org/10.1055/s-0036-1591893.

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A flexible and efficient carbonylative synthesis of thiochromenones from the commercially available materials by utilizing tert-butyl isocyanide as carbonyl source has been developed. This methodology efficiently constructs thiochromenones in moderate to excellent yields with the advantages of wide range of substrates and being applicable to library synthesis.
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39

Le, Thi Thu Huong, Chitose Youhei, Quy Hien Le, Thanh Binh Nguyen i Dinh Hung Mac. "Convenient one-pot access to 2H-3-nitrothiochromenes from 2-bromobenzaldehydes, sodium sulfide and β-nitrostyrenes". Organic & Biomolecular Chemistry 17, nr 26 (2019): 6355–58. http://dx.doi.org/10.1039/c9ob01060b.

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40

Ram, Vishnu Ji, P. Srivastava i Abhishek S. Saxena. "Carbanion-Induced Base-Catalyzed Synthesis of 1H-Isothiochromenes, Benzo[c]thiochromenes, Benzo[c]chromenes, and 1-Benzothiophenes through Ring-Transformation Reactions of 6-Aryl-2H-pyran-2-ones†". Journal of Organic Chemistry 66, nr 16 (sierpień 2001): 5333–37. http://dx.doi.org/10.1021/jo0100648.

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41

Munshi, Parthapratim, i T. N. Guru Row. "2H-Thiochromene-2-thione". Acta Crystallographica Section E Structure Reports Online 60, nr 11 (30.10.2004): o2168—o2170. http://dx.doi.org/10.1107/s1600536804026984.

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42

Peng, Jinsong, Chunxia Chen, Deqiang Wang, Peng Sun, Peiyun Jia i Yixia Yue. "Transition-Metal-Free One-Pot Tandem Synthesis of 4-Quinolone and 4H-Thiochromen-4-one Derivatives Through Sequential Nucleophilic Addition–Elimination–SNAr Reaction". Synthesis 49, nr 18 (19.07.2017): 4309–20. http://dx.doi.org/10.1055/s-0036-1588466.

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4-Quinolone and 4H-thiochromen-4-one derivatives are readily synthesized in a tandem one-pot manner in good to excellent yields. Starting from (Z)-β-chlorovinyl ketones, an intermolecular nucleo­philic addition of amines or sodium hydrogen sulfide to (Z)-β-chloro­vinyl ketones was followed by elimination of chlorine anion to give Z-enamine or thioenol intermediates, which can be transformed to 4-quinolone or 4H-thiochromen-4-one products through intramolecular SNAr reaction, respectively.
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43

Ram, Vishnu Ji, P. Srivastava i Abhisbek S. Saxena. "ChemInform Abstract: Carbanion-Induced Base-Catalyzed Synthesis of 1H-Isothiochromenes, Benzo[c]thiochromenes, Benzo[c]chromenes, and 1-Benzothiophenes Through Ring-Transformation Reactions of 6-Aryl-2H-pyran-2-ones." ChemInform 32, nr 49 (23.05.2010): no. http://dx.doi.org/10.1002/chin.200149097.

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44

Wen, Li-Rong, Qiang-Yu Shen, Wei-Si Guo i Ming Li. "Copper-catalyzed tandem arylation–cyclization of 2-alkynylaryl isothiocyanates with diaryliodonium salts: an efficient synthesis of thiochromeno[2,3-b]indoles". Organic Chemistry Frontiers 3, nr 7 (2016): 870–74. http://dx.doi.org/10.1039/c6qo00133e.

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A Cu-catalyzed arylation–cyclization approach is developed for the synthesis of thiochromeno[2,3-b]indoles through the S-arylation, 5-endo-trig cyclization, and Friedel–Crafts-type cyclization sequence.
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45

Sajadikhah, Seyed Sajad, i Mahmoud Nassiri. "Synthesis of 2H-thiochromene derivatives (microreview)". Chemistry of Heterocyclic Compounds 57, nr 11 (listopad 2021): 1073–75. http://dx.doi.org/10.1007/s10593-021-03026-x.

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46

Lozynskyi, Andrii, Julia Senkiv, Iryna Ivasechko, Nataliya Finiuk, Olga Klyuchivska, Nataliya Kashchak, Danylo Lesyk i in. "1,4-Naphthoquinone Motif in the Synthesis of New Thiopyrano[2,3-d]thiazoles as Potential Biologically Active Compounds". Molecules 27, nr 21 (4.11.2022): 7575. http://dx.doi.org/10.3390/molecules27217575.

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A series of 11-substituted 3,5,10,11-tetrahydro-2H-benzo[6,7]thiochromeno[2,3-d][1,3]thiazole-2,5,10-triones were obtained via hetero-Diels-Alder reaction of 5-alkyl/arylallylidene/-4-thioxo-2-thiazolidinones and 1,4-naphthoquinones. The structures of newly synthesized compounds were established by spectral data and a single-crystal X-ray diffraction analysis. According to U.S. NCI protocols, compounds 3.5 and 3.6 were screened for their anticancer activity; 11-Phenethyl-3,11-dihydro-2H-benzo[6,7]thiochromeno[2,3-d]thiazole-2,5,10-trione (3.6) showed pronounced cytotoxic effect on leukemia (Jurkat, THP-1), epidermoid (KB3-1, KBC-1), and colon (HCT116wt, HCT116 p53-/-) cell lines. The cytotoxic action of 3.6 on p53-deficient colon carcinoma cells was two times weaker than on HCT116wt, and it may be an interesting feature of the mechanism action.
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Munshi, Parthapratim, i T. N. Guru Row. "2H-Thiochromen-2-one". Acta Crystallographica Section E Structure Reports Online 58, nr 4 (8.03.2002): o353—o354. http://dx.doi.org/10.1107/s1600536802003628.

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Somasundaram, M., S. Athavan, K. K. Balasubramanian, R. Saiganesh i S. Kabilan. "3-[(4-Oxo-4H-thiochromen-3-yl)methyl]-4H-thiochromen-4-one". Acta Crystallographica Section E Structure Reports Online 69, nr 3 (9.02.2013): o358. http://dx.doi.org/10.1107/s1600536813001906.

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Mahato, Karuna, Prasanta Ray Bagdi i Abu T. Khan. "K2CO3 catalyzed regioselective synthesis of thieno[2,3-b]thiochromen-4-one oximes: access to the corresponding amine and nitroso derivatives". Organic & Biomolecular Chemistry 15, nr 26 (2017): 5625–34. http://dx.doi.org/10.1039/c7ob01033h.

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An unprecedented and efficient method for the synthesis of useful thieno[2,3-b]thiochromen-4-one oximes is accomplished via a thio[3 + 2] cyclization reaction of 4-hydroxydithiocoumarins and trans-β-nitrostyrenes in the presence of 10 mol% K2CO3 in ethanol under reflux conditions.
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Pandya, Dhananjay, i Yogesh Naliapara. "Synthesis and Anti Cervical Cancer Activity of Novel 5H-Thiochromeno [4,3-d]pyrimidines". Letters in Organic Chemistry 17, nr 4 (25.03.2020): 294–302. http://dx.doi.org/10.2174/1570178616666190705152116.

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A series of novel 5H-Thiochromeno[4,3-d]pyrimidine derivatives were synthesized, purified and characterized by different spectroscopy techniques such as 1H NMR, 13C NMR, Mass and Elemental Analysis. The new compounds were evaluated for their anti-cervical cancer activity on Human Cervical Cell Line HeLa. They were found to be potent anti-cervical cancer agents with GI50 values less than 10 μg/mL with respect to positive control drug Adriamycin.
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