Artykuły w czasopismach na temat „Therapy of digestive disorders”
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ALLAN, R. N. "Therapy of Digestive Disorders". Gut 47, nr 3 (1.09.2000): 457b—457. http://dx.doi.org/10.1136/gut.47.3.457b.
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DiMarino, Anthony J. "Therapy of digestive disorders". Gastroenterology 118, nr 6 (czerwiec 2000): 1275. http://dx.doi.org/10.1016/s0016-5085(00)70386-6.
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Isenberg, Gerard. "Therapy of Digestive Disorders". Gastrointestinal Endoscopy 52, nr 4 (październik 2000): 590–91. http://dx.doi.org/10.1067/mge.2000.108484.
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HANKS, JOHN B. "Therapy of Digestive Disorders". Annals of Surgery 234, nr 6 (grudzień 2001): 812–13. http://dx.doi.org/10.1097/00000658-200112000-00015.
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Goncharova, A. V., V. A. Kostylev i V. A. Bychkova. "The effects of gastrointestinal diet therapy for chronic pathologies of the digestive system in cats". Legal regulation in veterinary medicine, nr 1 (6.04.2024): 62–65. http://dx.doi.org/10.52419/issn2782-6252.2024.1.62.
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Gastroeintestinal diseases are one of the most common groups of diseases among small domestic animals. The gastro-intestinal tract includes the oral cavity, pharynx, esophagus, stomach, pancreas, small intestine and large intestine. General signs of digestive system disorders in cats with diseases of the digestive tract are vomiting, regurgitation, capricious appetite, as well as various defecation disorders: diarrhea, coprostasis, various inclusions in feces (blood, mucus). Diseases of the gastrointestinal tract of a chronic nature often involve the manifestation of symptoms on an ongoing basis or are recur-rent in nature. Chronic gastritis, enteropathy, pancreatitis require specialized diets that normalize the functioning of the digestive tract and help improve digestive function. These therapeutic complete diets are presented in ready-made feeds in dry (pellets) and wet (pates, pouches) variations from many manufacturers of industrial feeds. Dietary therapy is required long-term or lifelong; during remission it is the basis in the treatment of chronic patients. The compositions of these diets take into account the physiological and specific needs of the animal, and are also developed on the basis of easily digestible ingredients and a reduced amount of fat, but completely replenishing the required amount of calories.
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YRKM, Sai. "Understanding pancreatic disorders: Acute and chronic pancreatitis, pancreatic cancer and diabetes: A mini-review on a few of the most common pancreatic disorders". Annals of Pancreatic Disorders and Treatment 6, nr 1 (29.06.2024): 006–10. http://dx.doi.org/10.17352/apdt.000012.
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This mini-review provides an overview of pancreatic disorders, including acute and chronic pancreatitis, pancreatic cancer, and diabetes. The pancreas plays a crucial role in the digestive and endocrine systems of the body, producing enzymes that aid digestion and hormones that regulate blood sugar levels. Acute pancreatitis is a sudden and severe inflammation of the pancreas, often caused by gallstones or excessive alcohol consumption, and requires hospitalization, pain management, and intravenous fluids to support the pancreas. Chronic pancreatitis is a long-term inflammation of the pancreas that may lead to permanent damage and impairment of digestive function. Pancreatic cancer is a malignant tumor that forms in the pancreas and is often difficult to detect and diagnose in its early stages. Treatment for pancreatic cancer may include surgery, chemotherapy, and radiation therapy, depending on the type and stage of the cancer. Diabetes is a metabolic disorder that affects the body’s ability to produce or use insulin, and there are two main types of diabetes: type 1 and type 2. Type 1 diabetes is usually diagnosed in children and young adults and requires lifelong insulin therapy, while type 2 diabetes can often be managed with lifestyle modifications and medication.
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Gonchar, N. V., G. G. Alekhina, A. N. Tsapieva, A. N. Suvorov, E. I. Ermolenko, N. S. Lavrenova, S. G. Grigoriev i in. "Personalized symbiontic therapy for children with functional digestive disorders". Experimental and Clinical Gastroenterology, nr 12 (15.01.2022): 44–52. http://dx.doi.org/10.31146/1682-8658-ecg-196-12-44-52.
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The aim of the study was to identify the features of the influence of autoprobiotic and probiotic E. faecium strains on clinical and laboratory parameters in children with functional gastroenterological pathology.Patients and methods. In the period 2020–2021. 35 children over 3 years of age with functional gastrointestinal disorders (FGID) were observed on an outpatient basis, who were prescribed an autoprobiotic or probiotic strain E. faecium for therapeutic purposes and recommended a diet.The study protocol provided for clinical and anamnestic screening, FGID diagnostics; analysis of coprograms and assessment of the composition of the intestinal microbiota in children before and after a course of probiotics. The study of intestinal microbiota was carried out by RT-PCR in feces using a set of primers “Colonoflor”. One patient was excluded from the study due to refusal to take the autoprobiotic.The rest of the patients formed two groups: group 1 (n = 16)—children who received the autoprobiotic strain and group 2 (n = 18)—children who received the conditionally “reference” strain E. faecium L3. Probiotics were used in the form of a liquid form (which is a starter culture based on soy protein isolates containing 109 CFU in 1 ml) at a dose of 25 ml 2 times a day for 10 days.The results of using probiotic strains were evaluated on the basis of data from a survey of parents about the state of children and the dynamics of clinical manifestations, as well as changes in the values of indicators of coprograms and the composition of the intestinal microbiota.Statistical processing of the results was carried out using Student’s t-test, Mann-Whitney U-test; Wilcoxon test. The results were considered reliable at a significance level of p <0.05.Results. Studies of the effect of prescribing E. faecium L3 strain and an autoprobiotic strain to children with FROP revealed a positive effect on the clinical symptoms of the disease (in 29.4% and 25%, respectively) in the absence of undesirable side effects. Analysis of the dynamics of coprograms revealed an equivalent positive dynamics in the form of improvement in most of the studied stool characteristics. The study of the composition of the intestinal microbiota in the observed children revealed a low level of Lactobacilli and Enterococcus before and after the administration of probiotics. After the course of the E. faecium L3 strain, a significant increase in the content of F. prausnitzii was noted. The use of an autoprobiotic strain contributed to a significant decrease in the frequency of isolation of conditionally pathogenic bacteria in large numbersConclusion. The course appointment of autoprobiotic and probiotic E. faecium strains in children with FGID has a positive effect on clinical symptoms, improvement of most coprogram indices and normalization of the intestinal microbiota composition.
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Gazdanova, Gazdanova A. A., Lenkova N. I. Lenkova, Ryazantseva O. V. Ryazantseva i Solovieva S. A. Solovieva. "SKIN Disorders in the pathology of the digestive organs and malabsorption syndrome in general medical practice". Therapy 7_2023 (25.10.2023): 184–92. http://dx.doi.org/10.18565/therapy.2023.7.184-192.
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Shao, Xiyue. "Brief classification and latest therapy for lactose intolerance". Theoretical and Natural Science 6, nr 1 (3.08.2023): 299–305. http://dx.doi.org/10.54254/2753-8818/6/20230257.
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Lactose intolerance is a digestive problem with a high incidence worldwide. The disease occurs mainly due to a lack or deficiency of lactase in the body, which prevents effective digestion of lactose. Congenital lactose intolerance is caused by a genetic defect that prevents the body from producing enough lactase, and its incidence is relatively low. Secondary lactose intolerance is caused by other gastrointestinal disorders, such as celiac disease, and is relatively common. Functional lactose intolerance is the most common form of lactose intolerance, in which lactase activity is reduced or lactose absorption is impaired, but there is no apparent organic disease. This article lists several possible solutions for different types of lactose intolerance based on the latest research. In studies of lactose intolerance, scientists have found that the rate of lactose intolerance varies widely across populations, with significant differences in prevalence by race and region. In addition, several studies have shown a link between lactose intolerance and the composition of the gut microbiome. Therefore, the study of lactose intolerance has important implications for understanding how the human digestive system works and the relationship between the gut microbiome and health.
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Swami, Onkar C., i Neel J. Shah. "Functional dyspepsia and the role of digestive enzymes supplement in its therapy". International Journal of Basic & Clinical Pharmacology 6, nr 5 (24.04.2017): 1035. http://dx.doi.org/10.18203/2319-2003.ijbcp20171653.
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Functional dyspepsia represents a heterogeneous group of gastrointestinal disorders marked by the presence of upper abdominal pain or discomfort. Reported prevalence of dyspepsia in the world varies from 11-30%. Basic Pathophysiology of functional dyspeptic symptoms is unclear and is considered to occur due to a combination of visceral hypersensitivity, gastric motor dysfunction and psychological factors. Strategies such as acid suppression, prokinetics and H. pylori eradication have been used with some success. Transient deficiency in digestive enzymes is one of the contributors for functional dyspepsia. The primary digestive enzymes are proteases, amylases and lipases. A commonly used therapeutic approach in its treatment is the use of oral enzymes supplementation therapy. Commercially, digestive enzymes are obtained from plant, animal and microbial sources. This review summarizes the pathophysiology of functional dyspepsia, different pharmacological approaches and focuses on the safety and efficacy of digestive enzymes in managing dyspepsia. Keywords including functional dyspepsia, digestive enzymes, lipase, diastase, papain, pepsin, trypsin and chymotrypsin were searched in databases such as Google, Google Scholar, PubMed, pharmacopoeia and textbooks.
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Grinevich, Vladimir B., i Yuriy A. Kravchuk. "Diseases of the digestive organs and COVID-19". Russian Military Medical Academy Reports 40, nr 3 (2.09.2021): 39–44. http://dx.doi.org/10.17816/rmmar76269.
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With a new coronavirus infection (COVID-19), gastroenterological symptoms are often detected, which is due to both the damage to the digestive organs by the SARS-CoV-2 coronavirus and the exacerbation of chronic diseases, as well as aggressive multicomponent therapy. The severity of gastroenterological manifestations, primarily impaired liver function, is associated with a more severe and complicated course of COVID-19 infection. Numerous mechanisms of damage to the digestive organs in COVID-19 have been identified: direct damage by the virus due to resuscitation and multicomponent therapy, impaired central and peripheral nervous regulation, immunothrombotic syndrome, virus persistence in the gastrointestinal tract, induction of autoimmune reactions by the virus, humoral disorders (changes in serotonin levels, bradykinin, activation of mast cells). Violation of the microbial-tissue complex of the intestine and the permeability of the intestinal barrier, induced by the SARS-CoV-2 virus, ensures the formation and progression of chronic systemic inflammation, cytokine aggression, insulin resistance, endothelial dysfunction, which affect the severity of the infection. Therapy for patients with COVID-19 should include therapeutic approaches aimed at correcting disorders of the intestinal microbiota, intestinal barrier permeability, and relief of gastroenterological manifestations (bibliography: 20 refs).
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Karulina, Y. V., i T. I. Shevtsova. "Treatment of motility disorders of the upper digestive tract in children with autonomic dysfunction". CHILD`S HEALTH 19, nr 1 (4.03.2024): 7–12. http://dx.doi.org/10.22141/2224-0551.19.1.2024.1664.
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Background. Recently, there has been an increase in the prevalence of the autonomic nervous system (ANS) dysfunction and, against this background, motility disorders of the upper digestive tract (UDT), which, in turn, is the basis for the formation of chronic pathology of the digestive organs in children. The purpose was to improve the treatment of children with ANS dysfunction by studying the type of motility disorders of the UDT and prescribing therapy schemes depending on the type of disorders. Materials and methods. The article presents the results of clinical and anamnestic, laboratory, instrumental and psychological research of 109 children aged 6–16 years with autonomic dysfunction. Results. All surveyed children were divided into two representative groups: group I (main one, n = 87) — patients with autonomic dysfunction and impaired motility of the UDT who by type of motor function were divided into two subgroups: IA — with the acceleration of this function (n = 18) and IB — with its slowdown (n = 69); group II (comparison one, n = 22) — children with autonomic dysfunction without motility disorders of the UDT. In order to treat patients in subgroup IA, they, in turn, were divided into two therapeutic subgroups: IA1 — only basic therapy for autonomic dysfunction, and IA2 — in addition to basic therapy for autonomic dysfunction, correction of motility disorders of the UDT was performed. Patients of subgroup IB were also divided into two subgroups: IB1 — only basic therapy for autonomic dysfunction, and IB2 — in addition to basic therapy for autonomic dysfunction, correction of motility disorders of the UDT was conducted. The effectiveness of treatment for autonomic dysfunction syndrome has been proven, taking into account the type of motility disorders of the UDT. Different treatment regimens were proposed for children with ANS dysfunction without disorders and with the presence of motility disorders. The use in the comprehensive treatment of children with autonomic dysfunction syndrome of drugs that affect the motor function of the upper alimentary canal significantly increases its effectiveness during treatment for 30 days (89.0 versus 57.0 % when motor function slows down). Conclusions. The effectiveness of the comprehensive treatment for autonomic dysfunction has been proven, taking into account the type of motility disorders of the UDT. It reliably reduces the risk of recurrence of clinical manifestations of gastrointestinal pathology in children.
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Harsch, Igor Alexander, i Peter Christopher Konturek. "Adhesion Ileus after Fecal Microbiota Transplantation in Long-Standing Radiation Colitis". Case Reports in Gastrointestinal Medicine 2019 (2.01.2019): 1–4. http://dx.doi.org/10.1155/2019/2543808.
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Fecal microbiota transplantation (FMT) is a novel strategy for the therapy of dysbiosis-associated disorders via modulation of the gut microbiota. Intestinal dysbiosis is associated not only with digestive disorders, but also with a variety of extra-digestive disorders. A worldwide increasing number of FMT can be expected in the future as well as an increase in adverse events. We describe the case of a patient with chronic radiation colitis that developed adhesion ileus 2 days after FMT. Since these problems never occured before and the short time interval favours a causality, we speculate about FMT-induced alterations in gut motility causing a “trapping” of the small intestine in an adhesion and other mechanisms beyond “pure” coincidence.
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Plotnikova, Ekaterina Yu. "Psychosomatic patients at a gastroenterologist appointment". Clinical review for general practice 3, nr 4 (28.04.2022): 11–18. http://dx.doi.org/10.47407/kr2022.3.4.00144.
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Digestive diseases are closely associated with mood disorders such as anxiety and depression, studies have shown that symptoms of mood disorders in most patients with digestive tract diseases often cannot be recognized by doctors by gastroenterologists, and 40–90% of patients with psychological problems do not receive proper medical services and treatment. Functional gastro-intestinal disorders (FSID) have a significant impact on daily activities and quality of life, and cause great economic hardship due to direct medical costs and loss of productivity. FGID are psychosomatic diseases that are divided into esophageal, gastroduodenal, intestinal, functional abdominal pain syndrome, biliary and anorectal disorders. The article provides various pathophysiological mechanisms for the development of psychosomatic FGID. The article also presents several typical clinical cases of FGID. The principles of treating these disorders with an emphasis on psychotropic therapy are described.
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Moroz, E. V., E. N. Artemkin, E. V. Kryukov i V. A. Chernetsov. "Gastro-Intestinal Tract Complications During Antithrombotic Therapy". General Reanimatology 14, nr 3 (2.07.2018): 15–26. http://dx.doi.org/10.15360/1813-9779-2018-3-15-26.
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Use of antithrombotic aids (ATA) significantly impact the prevention of life-threatening cardiovascular complications. ATA applications, however, are associated with a wide range of adverse digestive system responses. Due to, continuously growing clinical use of ATA this problem has become a current challenge of contemporary medicine.Purpose of the study was to evaluate the patterns of digestive system damage in patients receiving ATA.Materials and Methods. 672 patients were examined, 91.0% males, 46.7±17.4 years of age, who had digestive system changes that occurred due to ATA intake. 71 patients were admitted for treatment after gastrointestinal (GI) bleeding; other patients were hospitalized because of disorders of the digestive system or erosive and ulcerous changes of the digestive system detected by endoscopy. The following parameters were evaluated: GI bleeding sources, character of complaints, the endoscopic patterns due to intake of different ATAs (low doses of aspirin, warfarin, clopidogrel, dabigatran, rivaroxaban, low-molecular heparin, combined therapy), and of risk factors for GI complications.Results. The sources of GI bleeding (n=71) included gastric ulcers and/or erosions (39.4%), duodenum ulcers and/or erosions (21.1%), colon ulcers and/or erosions (28.2%), unknown (11.3%). The majority of 672 patients noticed various complaints: sensation of heaviness in epigastrium (62.8%), gastralgia (46.7%), burning sensation (34.3%). Endoscopy found erosive esophagitis (13.2%), ulcers in stomach and/or duodenum (11.6%), multiple ( 10) erosions of stomach or duodenum (17.1%), sporadic erosions of stomach or duodenum (24.4%). In 32.3% cases no erosive or ulcerous alterations were found. H. pylori was identified in 57.9% of patients. There was no significant difference in character of alterations in the upper digestive system between patients who received different ATA treatment, except of frequent erosive esophagitis in those patients who received dabigatran (16.8%). The elderly age ( 65 years), ulcer history, concomitant intake of NSAIDS, H. pylori presence, and smoking habit were associated with a higher occurrence of pathological alterations of digestive system. Presence of gastralgia did not correlate with the development of erosive and ulcerous alterations.Conclusion. In majority of patients who received ATA, the commonly observed erosive and ulcerous alterations in the digestive system might become a source of bleeding.
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Song, Bong Kil, Angelique G. Brellenthin i Duck-chul Lee. "Associations Between Muscular Strength And Digestive System Disorders In Older Adults". Medicine & Science in Sports & Exercise 52, nr 7S (lipiec 2020): 736. http://dx.doi.org/10.1249/01.mss.0000683176.49097.5b.
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Ipatov, Andrey A., i Maria G. Ipatova. "Management of functional gastrointestinal disorders in children. Focus on restoring intestinal microenvironment and motility". Meditsinskiy sovet = Medical Council, nr 1 (21.03.2021): 125–32. http://dx.doi.org/10.21518/2079-701x-2021-1-125-132.
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Functional gastrointestinal disorders in children are one of the most common reasons why parents visit a pediatrician. Functional gastrointestinal disorders include various persistent combinations of chronic or recurrent gastrointestinal symptoms in the absence of any organic pathology in the gastrointestinal tract (structural abnormalities, inflammatory changes, infections, or tumours) and metabolic disturbances. The article presents details on the mechanisms of development, clinical manifestations, diagnostic criteria and approaches to the treatment of functional gastrointestinal disorders. Clinical manifestations of functional gastrointestinal disorders vary depending on age and characteristics of physical and intellectual development. In more than half of children, they are observed in various combinations, less often as one isolated symptom. The drug therapy should consider the main components of pathogenesis and facilitate the solution of the following issues: improvement of digestion; restoration of intestinal microenvironment and motility; reduction of visceral hypersensitivity. Special attention is paid to the management of motor disorders and restoration of intestinal microenvironment using symbiotics. When choosing a supplement, it is advisable to focus on the composition of probiotic strains, which should comply with the WGO global guidelines (Bifidobacterium bifidum, Lactobacillus acidophilus, etc.).Prescription of peripheral δ-, μ- и κ-receptor agonists – trimebutine and pre- and probiotics combinations to children with functional gastrointestinal disorders results in decreased signs of functional disorders of the digestive tract. By acting on the enkephalinergic system, trimebutine regulates the bowel activity, improves motility, and reduces visceral hypersensitivity. Trimebutine is included in the Russian guidelines for the diagnosis and treatment of functional disorders of the digestive tract in children, as well as in the clinical guidelines for the treatment of irritable bowel syndrome, functional dyspepsia, and functional abdominal pain.
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Chentsov, D. V., Yu V. Kokovina, B. I. Aslanov, T. M. Chirkina, E. A. Antonova, A. V. Tiselko i O. V. Shiray. "Characteristics of digestive system lesions in patients with diabetes mellitus". Medical alphabet, nr 35 (12.01.2023): 29–36. http://dx.doi.org/10.33667/2078-5631-2022-35-29-36.
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Lesions of the digestive system in diabetes mellitus are of secondary nature and arise due to autonomic neuropathy. As a result of hyperglycemia, lesions of the esophagus, stomach, small and large intestine develop. The most common disorder of the digestive system in diabetes is gastroparesis. The diagnosis of gastroparesis is currently insufficient. It is connected with low awareness and, as a consequence, rare visit of patients to specialists, and also with similarity of clinical symptoms with other functional disorders of gastrointestinal tract. The main risk factors for gastroparesis are hyperglycemia, smoking, alcohol, and certain medications. Most patients with gastroparesis suffer from depression and increased anxiety. Taking medications to treat depression negatively affects the function of the digestive system. This problem interferes with patients' quality of life. During the pandemic of coronavirus infection, the number of patients seeking medical care due to exacerbation of gastrointestinal disorders increased. The question of etiology is subject to further study. This review also considers the effect of cholecystectomy on the development of gastroparesis in these patients. These patients need special monitoring of glucose levels to prescribe timely antidiabetic therapy and prevent future gastroparesis. For the treatment of lesions of the digestive system in diabetes mellitus, a special diet, in particular the exclusion of hard-to-digest fiber, fatty foods, inclusion of vitamin complexes and normalization of the microbiota plays a paramount role. The main therapeutic value is the timely diagnosis and normalization of glucose levels.
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Chentsov, D. V., Yu V. Kokovina, B. I. Aslanov, T. M. Chirkina i A. V. Tiselko. "Characteristics of digestive system lesions in patients with diabetes mellitus". Experimental and Clinical Gastroenterology, nr 11 (23.01.2023): 216–26. http://dx.doi.org/10.31146/1682-8658-ecg-207-11-216-226.
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Lesions of the digestive system in diabetes mellitus (DM) are of secondary nature and arise due to autonomic neuropathy. As a result of hyperglycemia, lesions of the esophagus, stomach, small and large intestine develop. The most common disorder of the digestive system in diabetes is gastroparesis. The diagnosis of gastroparesis is currently insufficient. It is connected with low awareness and, as a consequence, rare visit of patients to specialists, and also with similarity of clinical symptoms with other functional disorders of gastrointestinal tract (GIT). The main risk factors for gastroparesis are hyperglycemia, smoking, alcohol, and certain medications. Most patients with gastroparesis suffer from depression and increased anxiety. Taking medications to treat depression negatively affects the function of the digestive system. This problem interferes with patients’ quality of life. During the pandemic of coronavirus infection, the number of patients seeking medical care due to exacerbation of gastrointestinal disorders increased. The question of etiology is subject to further study. This review also considers the effect of cholecystectomy on the development of gastroparesis in these patients. These patients need special monitoring of glucose levels to prescribe timely antidiabetic therapy and prevent future gastroparesis. For the treatment of lesions of the digestive system in diabetes mellitus, a special diet, in particular the exclusion of hard-to-digest fiber, fatty foods, inclusion of vitamin complexes and normalization of the microbiota plays a paramount role. The main therapeutic value is the timely diagnosis and normalization of glucose levels.
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Nikulina, D. "Secondary amyloidosis as a complication of rheumatoid arthritis in a patient with low adherence to treatment". Clinical Medicine and Pharmacology 8, nr 4 (1.02.2023): 35–40. http://dx.doi.org/10.12737/2409-3750-2023-8-4-35-40.
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A case of secondary amyloidosis in rheumatoid arthritis in a 28-year-old girl who did not receive sufficient basic therapy due to low adherence to treatment is presented. During the course of the disease, proteinuria developed, widespread edema, digestive disorders. The development of symptoms over time, the process of diagnosis, the selection of therapy, rehabilitation are demonstrated.
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Plotnikova, E. Yu, K. A. Krasnov i O. A. Krasnov. "Exocrine insufficiency in pancreatic diseases and other digestive disorders: diagnosis and management". Russian Medical Inquiry 6, nr 5 (2022): 266–71. http://dx.doi.org/10.32364/2587-6821-2022-6-5-266-271.
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This paper reviews recent data on exocrine pancreatic insufficiency (EPI). The authors describe in detail the etiology and pathogenesis of both pancreatogenic EPI (resulting from chronic pancreatitis, pancreatic cancer, cystic fibrosis) and EPI resulting from celiac disease or diabetes. Current tests for assessing exocrine function of the pancreas are discussed. This article focuses on the available and informative test to measure pancreatic (fecal) elastase 1 levels in moderate-to-severe EPI. Its advantages are the lack of the effect of diet or fasting on test results and the possibility of performing this test in the setting of pancreatic enzyme replacement therapy. The authors also uncover the rules of correcting EPI using enzymes and management strategies in pancreatic enzyme replacement therapy non-responders involving, in particular, acid suppression therapy. Timely prescription of enzymes in adequate doses to address maldigestion and malabsorption and improvement of strategies to overcome gastric and intestinal pH barriers to guarantee proper enzyme delivery in the duodenum are important. KEYWORDS: pancreas, exocrine pancreatic insufficiency, pancreatic cancer, diabetes, celiac disease, cystic fibrosis, pancreatic (fecal) elastase 1, pancreatin, omeprazole. FOR CITATION: Plotnikova E.Yu., Krasnov K.A., Krasnov O.A. Exocrine insufficiency in pancreatic diseases and other digestive disorders: diagnosis and management. Russian Medical Inquiry. 2022;6(5):266–271 (in Russ.). DOI: 10.32364/2587-6821-2022-6-5-266-271.
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Nunes da Costa, Erika Alessandra Pellison, Cassiano Victória i Carlos Magno Castelo Branco Fortaleza. "Predictors of development of cardiac and digestive disorders among patients with indeterminate chronic Chagas Disease". PLOS Neglected Tropical Diseases 15, nr 8 (13.08.2021): e0009680. http://dx.doi.org/10.1371/journal.pntd.0009680.
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American trypanosomiasis (Chagas disease, CD) affects circa 7 million persons worldwide. While of those persons present the asymptomatic, indeterminate chronic form (ICF), many will eventually progress to cardiac or digestive disorders. We studied a nonconcurrent (retrospective) cohort of patients attending an outpatient CD clinic in Southeastern Brazil, who were admitted while presenting the ICF in the period from 1998 through 2018 and followed until 2019. The outcomes of interest were the progression to cardiac or digestive CD forms. We were also interested in analyzing the impact of Benznidazole therapy on the progression of the disease. Extensive review of medical charts and laboratory files was conducted, collecting data up to year 2019. Demographics (upon inclusion), body mass index, comorbidities (including the Charlson index) and use of Benznidazole were recorded. The outcomes were defined by abnormalities in those test that could not be attributed to other causes. Statistical analysis included univariate and multivariable Cox regression models. Among 379 subjects included in the study, 87 (22.9%) and 100 (26.4%) progressed to cardiac and digestive forms, respectively. In the final multivariable model, cardiac disorders were positively associated with previous coronary syndrome (Hazzard Ratio [HR], 2.42; 95% Confidence Interval [CI], 1.53–3.81) and negatively associated with Benznidazole therapy (HR, 0.26; 95%CI, 0.11–0.60). On the other hand, female gender was the only independent predictor of progression to digestive forms (HR, 1.56; 95%CI, 1.03–2.38). Our results point to the impact of comorbidities on progression do cardiac CD, with possible benefit of the use of Benznidazole.
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Fatenkov, O. V., E. А. Sadomova i O. A. Rubanenko. "METHOD OF GRAVITATIONAL THERAPY IN TREATMENT OF GASTROINTESTINAL TRACT DISORDERS". Science and Innovations in Medicine 1, nr 4 (15.12.2016): 14–17. http://dx.doi.org/10.35693/2500-1388-2016-0-4-14-17.
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Aim - to increase the efficiency of treatment of patients with gastrointestinal tract disorders by including the method of gravitational therapy into the treatment complex. Methods. The method of gravitational therapy was used to achieve beneficial impact on the diseases of the gastrointestinal tract. Results. The paper presents the relevance of the treatment of gastrointestinal tract diseases and the search for new treatment options that have fewer side effects and reduce the cost of treatment. It also explores the influence of gravitational therapy on diseases of the gastrointestinal tract, and further introduction of this method in the treatment regimens. It specifies the importance of complementing medical treatment of gastrointestinal tract diseases with the physiotherapy methods. We present indications for diseases of the digestive system and contraindications for gravitational therapy. Conclusion.Positive influence of gravitational therapy in cases of gastrointestinal tract disorders was revealed.
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Belyaeva, Irina A., Elena P. Bombardirova i Tatyana V. Turti. "Yoghurts in Infants’ Nutrition: Opportunities of Infectious and Non-Communicable Diseases’ Prevention". Current Pediatrics 22, nr 4 (25.08.2023): 298–304. http://dx.doi.org/10.15690/vsp.v22i4.2591.
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This review provides data on the use of yogurts in infants’ nutrition. The properties of these fermented milk products and associated urgent and delayed sanogenetic effects are described. The experience of yogurts (enriched with pre- and probiotics) implementation in the nutrition therapy of children who have undergone infectious diseases is shown. The yogurt usage for intestinal microbiota disorders correction in children with functional digestive disorders and chronic somatic pathology is discussed.
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Salikhov, I. A., A. A. Agafonov i D. I. Gafurov. "Surgical correction of acid-producing function of the stomach by selective mucosectomy". Kazan medical journal 68, nr 2 (15.04.1987): 87–89. http://dx.doi.org/10.17816/kazmj96015.
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Gastric and duodenal ulcer is one of the most common diseases of the digestive tract. Failure of conservative therapy forces to resort to surgical treatment, aimed at suppression of the main aggressive factors leading to ulcerogenesis - reduction of hydrochloric acid and pepsin production, elimination of motor and evacuatory disorders.
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Mărginean, Cristina Oana, Lorena Elena Meliț, Reka Borka Balas, Anca Meda Văsieșiu i Tudor Fleșeriu. "The Crosstalk between Vitamin D and Pediatric Digestive Disorders". Diagnostics 12, nr 10 (27.09.2022): 2328. http://dx.doi.org/10.3390/diagnostics12102328.
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Vitamin D is a cyclopentane polyhydrophenanthrene compound involved mainly in bone health and calcium metabolism but also autophagy, modulation of the gut microbiota, cell proliferation, immune functions and intestinal barrier integrity. The sources of vitamin D include sunlight, diet and vitamin D supplements. Vitamin D3, the most effective vitamin D isoform is produced in the human epidermis as a result of sunlight exposure. Vitamin D undergoes two hydroxylation reactions in the liver and kidney to reach its active form, 1,25-dihydroxyvitamin D. Recent studies highlighted a complex spectrum of roles regarding the wellbeing of the gastrointestinal tract. Based on its antimicrobial effect, it was recently indicated that vitamin D supplementation in addition to standard eradication therapy might enhance H. pylori eradication rates. Moreover, it was suggested that low levels of vitamin D might also be involved in the acquisition of H. pylori infection. In terms of celiac disease, the negative effects of vitamin D deficiency might begin even during intrauterine life in the setting of maternal deficiency. Moreover, vitamin D is strongly related to the integrity of the gut barrier, which represents the core of the pathophysiology of celiac disease onset, in addition to being correlated with the histological findings of disease severity. The relationship between vitamin D and cystic fibrosis is supported by the involvement of this micronutrient in preserving lung function by clearing airway inflammation and preventing pathogen airway colonization. Moreover, this micronutrient might exert anticatabolic effects in CF patients. Inflammatory bowel disease patients also experience major benefits if they have a sufficient level of circulating vitamin D, proving its involvement in both induction and remission in these patients. The findings regarding the relationship between vitamin D, food allergies, diarrhea and constipation remain controversial, but vitamin D levels should be monitored in these patients in order to avoid hypo- and hypervitaminosis. Further studies are required to fill the remaining gaps in term of the complex impact of vitamin D on gastrointestinal homeostasis.
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Ilie, Ovidiu-Dumitru, Ioana-Miruna Balmus, Samson Guenne, Mahmoud a. ali i Alin Ciobica. ""Animal Models in the Microbiota vs. Irritable Bowel Syndrome Manifestations - Preliminary Aspects on the Probiotic Therapy in Irritable Bowel Syndrome"". Annals of the Academy of Romanian Scientists Series on Biological Sciences 9, nr 1 (2020): 80–87. http://dx.doi.org/10.56082/annalsarscibio.2020.1.80.
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Irritable bowel syndrome (IBS) is a common functional disorder that affects the digestive system and especially the large intestine, expressed mainly through symptoms including diarrhea, constipation, abdominal pain, bloating and cramping. It could be associated with mood disorders including depression and anxiety. Additionally one of the causes of IBS could be a change in gut microflora. Also, could exert a significant role in this context and their potential benefits in maintaining a healthy gut. Here we discussed the possible role of therapy with probiotics in IBS, as well as some important animal models regarding this topic.
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Anisa, Elisa Citra, Sudarsini Sudarsini i Sulthoni Sulthoni. "The Implementation of Diet Therapy for Autistic Students". Jurnal Penelitian dan Pengembangan Pendidikan Luar Biasa 7, nr 1 (31.07.2020): 26. http://dx.doi.org/10.17977/um029v7i12020p26-29.
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Autistic children tend to experience digestive disorders. Therefore, autistic children must take diet therapy. This research used qualitative method. The results showed that (1) Implementation of diet therapy: preparation, implementation, monitoring and evaluation. (2) Obstacles in the implementation of diet therapy: autistic students themselves, parents, and the difficulty of getting certain food. (3) Impact of diet therapy: students are more silent and can sit quietly during the implementation of ABA therapy. The implementation of diet therapy for autistic students will have a good impact if applied correctly. Suggestions in this research, do not let a diet leak even if only once.
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Strokova, T. V., M. E. Bagaeva, E. V. Pavlovskaya, A. I. Zubovich, N. N. Taran i Z. A. Abdulmanapova. "Nutritional status in children with cholestasis: diagnostic approaches and correction possibilities". Voprosy detskoj dietologii 21, nr 1 (2023): 36–44. http://dx.doi.org/10.20953/1727-5784-2023-1-36-44.
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Cholestasis is associated with various chronic liver diseases both in childhood and in adulthood. Stagnation of bile and its insufficient secretion into the digestive tract cause malabsorption of fats and fat-soluble vitamins. Increased energy requirements and inadequate energy intake lead to eating disorders, which are especially dangerous in childhood. Weight and height deficits in children with cholestasis increase the risk of complications and accelerate the progression of the disease. A comprehensive assessment of nutritional status using all available methods allows timely initiation of correction of the detected disorders. This article presents current approaches to the diagnosis of nutritional status disorders and features of diet therapy in children with chronic liver diseases occurring with cholestasis. Key words: cholestasis, children, malabsorption, diet therapy, nutritional status
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Tao, Jide. "Intervention of innovative reform in medical education on students’ anxiety disorders". CNS Spectrums 28, S2 (październik 2023): S138—S139. http://dx.doi.org/10.1017/s109285292300603x.
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BackgroundGeneralized Anxiety Disorder (GAD) is a common mental illness among adolescents, characterized by generalized and persistent anxiety, lack of clear targets, nervousness, and even involvement of the respiratory and digestive systems. Cognitive behavioral therapy has an improvement effect on anxiety disorders. This research was conducted to provide treatment interventions for students with anxiety disorders.Subjects and MethodsFirstly, 90 adolescent anxiety disorder patients aged 13-22 from a certain hospital were selected. Next, they were randomly divided into a control group and an observation group. The control group received routine drug treatment, while the observation group received cognitive behavioral therapy on this basis. The final treatment period was 16 weeks, with a round of treatment every 8 weeks. Statistical software SPSS23.0 was used for statistical description, and t-tests were used for measurement data.ResultsAfter a round of 8-week treatment, there was no statistically significant difference in the anxiety symptom scale scores between the two groups (P>0.05). After the second round, the Hamilton Anxiety Scale scores of the observation group were significantly lower than those of the control group (P<0.05); The difference in stress status scores at different times was significantly lower in the observation group than in the control group after the start of the second round (P<0.05). In short, cognitive behavioral therapy has a relieving effect on students’ anxiety disorders.ConclusionsDrug therapy is mostly targeted at adult patients. However for adolescent patients, it is necessary to gradually combine cognitive behavioral therapy to promote the relief of anxiety disorders in students.
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Malfertheiner, Peter. "STW 5 (Iberogast) Therapy in Gastrointestinal Functional Disorders". Digestive Diseases 35, Suppl. 1 (2017): 25–29. http://dx.doi.org/10.1159/000485410.
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Background: Functional gastrointestinal disorders (FGIDs) are very common and affect populations worldwide. A majority of patients are affected by a variety of heterogenous gastrointestinal symptoms (GIS) related to the upper and lower digestive system with frequent overlap and mostly of mild to moderate degree. The herbal medicinal preparation STW 5 is documented as an effective therapeutic option for treating FGID. Studies Conducted in Summary: STW 5 has been in use for more than 50 years in clinical practice and proven to be effective and safe in the management of FGID. The high efficacy of STW 5 on symptoms clustered in functional dyspepsia (FD) and irritable bowel syndrome (IBS) as well as on individual abdominal symptoms is demonstrated in 5 controlled, randomized double-blind studies in FD and in one trial conducted in patients with IBS. In addition the beneficial therapeutic effect of STW 5 on FGD as well as safety issues have been reported in a series of non interventional studies conducted in several thousands of adult patients and including 980 children. An additional study has been performed addressing the question as to how quickly the therapeutic effect is obtained after STW 5 administration. Key Messages from These Studies: STW 5 is an effective phyto-medication for treating patients with FD and IBS. STW 5 acts beneficially on abdominal symptom clusters as well as on individual GIS in adults and children. The time to onset of action is rapid, well tolerated and safe. The repetitive use of STW 5 is an appropriate option in clinical practice for patients with FGID.
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Rybachuk, Zh V., I. V. Prisyazhnyuk i K. O. Chirta-Sinelnyk. "“EMBIOTIC” Ltd. “EM-Ukraine” – an alternative to antibiotic therapy for digestive disorders in calves". Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies 23, nr 102 (30.03.2021): 8–13. http://dx.doi.org/10.32718/nvlvet10202.
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The prophylactic efficacy of diarrhea in calves with different methods and doses of feed additive “EMBIOTIC” during the first 14 days of life was studied. Almost 50 % of dairy calves had symptoms of diarrhea. Effective treatment regimens for such animals included one of the antibiotics (azithromycin or 15 % amoxicillin emulsion) and, if necessary, sulfonamide drugs (trimeratinvet with the drugs sulfadimesine and trimethoprim) or the drug sulfate lozin, which includes sulfonamide and antibiotics (tylosin tartrate, oxytetracycline, sulfadimesine, trimethoprim). Simultaneously, symptomatic therapy was performed with the use of refinery – 10 % solution of ketoprofen in the form of the drug ketonil, which provided analgesia and reduction of body temperature to physiological limits. Еhere is always a drug cyanophore (LR butaphosphane and cyanocobalamin) as a general stimulant in the scheme. To conduct the experiment, 5 groups of animals were formed, 6 in each, age – the first day after birth. From the first to the 14th day of life, from the first or second colostrum, each calf from different groups was given daily 5 cm3, 10 cm3 and 15 cm3 of feed additive “EMBIOTIC”, respectively. The fourth experimental group – control (probiotic was not received), and the fifth – calves obtained from cows, which 10–14 days before and after calving daily with feed or water received 80–100 cm3 of feed additive “EMBIOTIC”, and calves the tested drug was not used. During the experiment twice a day (morning and evening), clinical observation and examination of calves of all experimental groups. Two days later, calves that received 5 cm3, 10 cm3 and 15 cm3 of feed additive “EMBIOTIC” were registered to improve appetite, increased mobility and prolonged and pronounced sleep. In animals that received with milk 10 cm3 and 15 cm3 of feed additives, during the observation period, disorders of the digestive system were not registered. Two calves, receiving 5 cm3 of EMBIOTICS daily, had symptoms of minor diarrhea for only 12 days, but there was no appetite. After 24 hours, the symptoms of indigestion went away on their own without the use of any drugs. Newborn calves obtained from cows that received “EMBIOTIC” as part of their diet or water were rated 9–10 on the Apgar scale. From the 3rd day they ate straw and they registered chewing gum for 3.7 ± 0.2 days of life. Within 14 days of observation of disorders of the gastrointestinal tract, they were not registered. Thus, the feed additive “EMBIOTIC” provides prevention of diarrhea in calves.
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Shapiro, Michael S. "Therapy of Digestive Disorders: A Companion to Sleisenger and Fortran's Gastroenterological and Liver Disease". Annals of Internal Medicine 133, nr 8 (17.10.2000): 660. http://dx.doi.org/10.7326/0003-4819-133-8-200010170-00030.
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Firsova, L. D. "Antidepressants in the Practice of a Gastroenterologist". Effective Pharmacotherapy 17, nr 4 (18.04.2021): 90–93. http://dx.doi.org/10.33978/2307-3586-2021-17-4-90-93.
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Antidepressants are widely used in modern gastroenterology. The article discusses the indications for the prescribing antidepressants to the patients with disorders of the digestive system, examines the features of antidepressant therapy in the gastroenterological patients with comorbid cardiovascular pathology. The main groups of antidepressants (selective serotonin reuptake inhibitors and tricyclic antidepressants) are compared in terms of therapeutic effects and potential side effects
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Tursi, Antonio, Valerio Papa, Loris Riccardo Lopetuso, Carlo Romano Settanni, Antonio Gasbarrini i Alfredo Papa. "Microbiota Composition in Diverticular Disease: Implications for Therapy". International Journal of Molecular Sciences 23, nr 23 (26.11.2022): 14799. http://dx.doi.org/10.3390/ijms232314799.
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Gut microbiota (GM) composition and its imbalance are crucial in the pathogenesis of several diseases, mainly those affecting the gastrointestinal tract. Colon diverticulosis and its clinical manifestations (diverticular disease, DD) are among the most common digestive disorders in developed countries. In recent literature, the role of GM imbalance in the onset of the different manifestations within the clinical spectrum of DD has been highlighted. This narrative review aims to summarize and critically analyze the current knowledge on GM dysbiosis in diverticulosis and DD by comparing the available data with those found in inflammatory bowel disease (IBD). The rationale for using probiotics to rebalance dysbiosis in DD is also discussed.
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Marincas, Daniela, Simina Angelescu i Vlad Dima. "Dynamics of the mother-child relationship in the presence of functional gastrointestinal disorders in infants". Romanian Medical Journal 68, S5 (30.11.2021): 92–97. http://dx.doi.org/10.37897/rmj.2021.s5.17.
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Motherhood is still insufficiently explored regarding its psychological aspects. Maternity brings an innovative perspective in the diagnosis and treatment of various disorders of mother and child in the first year of life. Functional gastrointestinal disorders are the most common diagnosis in Pediatric Gastroenterology, being recognized as a group of diseases difficult to diagnose and manage. Among diagnosed and treated infants, some display a long-lasting suffering, which shows that a number of clinical aspects may be insufficiently explored. One such dimension is the one described under the term "birth-related illnesses", i.e. psychosomatic symptoms that occur in the infant as a result of a deficient or non-existent emotional relationship with the mother. This paper aims to illustrate how the mother-infant emotional relationship influences the functional digestive manifestations of the infant, their relational dynamics, and the development of symptoms, with and without specific maternal therapeutic intervention. The results represent an argument for the use of the mother-child dyadic therapy for improving the infant's digestive function.
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Sha, S., J. Liang, M. Chen, B. Xu, C. Liang, N. Wei i K. Wu. "Systematic review: faecal microbiota transplantation therapy for digestive and nondigestive disorders in adults and children". Alimentary Pharmacology & Therapeutics 39, nr 10 (18.03.2014): 1003–32. http://dx.doi.org/10.1111/apt.12699.
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Avci, Recep, Kiara J. W. Miller, Niranchan Paskaranandavadivel, Leonard A. Bradshaw, Maggie-Lee Huckabee i Leo K. Cheng. "Bioelectrical Signals for the Diagnosis and Therapy of Functional Gastrointestinal Disorders". Applied Sciences 10, nr 22 (16.11.2020): 8102. http://dx.doi.org/10.3390/app10228102.
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Coordinated contractions and motility patterns unique to each gastrointestinal organ facilitate the digestive process. These motor activities are coordinated by bioelectrical events, sensory and motor nerves, and hormones. The motility problems in the gastrointestinal tract known as functional gastrointestinal disorders (FGIDs) are generally caused by impaired neuromuscular activity and are highly prevalent. Their diagnosis is challenging as symptoms are often vague and difficult to localize. Therefore, the underlying pathophysiological factors remain unknown. However, there is an increasing level of research and clinical evidence suggesting a link between FGIDs and altered bioelectrical activity. In addition, electroceuticals (bioelectrical therapies to treat diseases) have recently gained significant interest. This paper gives an overview of bioelectrical signatures of gastrointestinal organs with normal and/or impaired motility patterns and bioelectrical therapies that have been developed for treating FGIDs. The existing research evidence suggests that bioelectrical activities could potentially help to identify the diverse etiologies of FGIDs and overcome the drawbacks of the current clinically adapted methods. Moreover, electroceuticals could potentially be effective in the treatment of FGIDs and replace the limited existing conventional therapies which often attempt to treat the symptoms rather than the underlying condition.
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Matiș, Loredana, Bogdana Ariana Alexandru, Radu Fodor, Lucia Georgeta Daina, Timea Claudia Ghitea i Silviu Vlad. "Effect of Probiotic Therapy on Neuropsychiatric Manifestations in Children with Multiple Neurotransmitter Disorders: A Study". Biomedicines 11, nr 10 (26.09.2023): 2643. http://dx.doi.org/10.3390/biomedicines11102643.
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Probiotics, also known as psychobiotics, have been linked to cognitive functions, memory, learning, and behavior, in addition to their positive effects on the digestive tract. The purpose of this study is to examine the psychoemotional effects and cognitive functioning in children with gastrointestinal disorders who undergo psychobiotherapy. A total of 135 participants, aged 5–18 years, were divided into three groups based on the pediatrician’s diagnosis: Group I (Control) consisted of 37 patients (27.4%), Group II included 65 patients (48.1%) with psychoanxiety disorders, and Group III comprised 33 individuals (24.4%) with psychiatric disorders. The study monitored neurotransmitter levels such as serotonin, GABA, glutamate, cortisol, and DHEA, as well as neuropsychiatric symptoms including headaches, fatigue, mood swings, hyperactivity, aggressiveness, sleep disorders, and lack of concentration in patients who had gastrointestinal issues such as constipation, diarrhea, and other gastrointestinal problems. The results indicate that psychobiotics have a significant impact on reducing hyperactivity and aggression, and improving concentration. While further extensive studies are needed, these findings offer promising insights into the complexity of a child’s neuropsychic behavior and the potential for balancing certain behaviors through psychobiotics.
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Kharitonova, L. A., K. I. Grigoriev, I. M. Osmanov, S. N. Borzakova, E. V. Skorobogatova, V. A. Shashel, S. Yu Matalaeva i D. A. Shurygina. "Digestive comorbidity in pediatrics". Experimental and Clinical Gastroenterology 1, nr 1 (17.03.2021): 166–75. http://dx.doi.org/10.31146/1682-8658-ecg-185-1-166-175.
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Rationale. In recent decades, the number of children has increased with chronic diseases characterized by systemic lesions and frequent involvement of the digestive tract, complicating the diagnosis and choice of therapeutic strategy. As the number of diseases in a child increases, the cost of diagnosis and treatment grows exponentially. Given the comorbidity, physicians prescribe multiple medications (polypragmasy), which can lead to adverse effects.First-line physicians often lack the knowledge about the clinical and therapeutic features of managing comorbid patients. Practical healthcare lacks a “team strategy” for these patients’ treatment, leading to ineffective management of patients by subspecialist physicians significantly affecting the prognosis of the disease and even the life of the patient. The “narrowly specialized” model of medicine is inadequate. An integrative model of healthcare should replace it. Meanwhile, there are currently no international and national recommendations for this problem focused on the needs of “first line” physicians, including pediatric specialists. All the above urged us to provide an in-depth study of this problem in the current literature.The aim of this literature review was to study the frequency and structure of comorbid conditions in pediatric practice to optimize their diagnostics, therapeutic tactics, and the development of preventive measures.Results and discussion. The structure of comorbidity differs in different age categories. The comorbidity in children depends mainly on the genetically programmed disorders of metabolism and functioning of cells and tissues, disorders of nutritional status, infectious factors, and interference (pathogenetic relationship of diseases). Understanding the etiology and pathogenesis of comorbid conditions in children, one should identify the Chronic Noncommunicable Diseases formation risk groups and develop a plan for their prevention. Prevention of comorbid chronic noncommunicable diseases should be carried out as part of the “full life cycle”, from the antenatal period (the health of the future mother) to adolescence, using an integrative approach (impact on the child’s physical and mental condition) with teaching patients and their parents the basics of proper diet, healthy lifestyle, sufficient physical activity, and positive attitude.Knowledge of causal and complicated comorbidity will contribute to the development of optimal diagnostic tactics for the search of the root cause and the selection of efficient therapy for trigger disease, which will avoid polypragmasy. The pediatric physician should play the primary role in the follow-up of comorbid patients. It is necessary to expand the competencies of the pediatric physician with the revision of approaches to his professional training.The development of clinical guidelines and algorithms for the management of comorbid patients and the collaboration of physicians of various specialties (formation of multidisciplinary teams), while observing the principle of “one doctor”, will significantly improve the quality of medical care for comorbid patients, which will improve their quality of life and significantly decrease the cost of rehabilitation measures.
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Alabbody, Huda Hameed K. "HERBEL THERAPY PRACTICE FOR LOCALL LIVESTOCK". Iraqi Journal of Market Research and Consumer Protection 15, nr 2 (31.12.2023): 244–51. http://dx.doi.org/10.28936/jmracpc15.2.2023.(23).
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The herbs have a huge role in development of pharmacology besides the role of veterinary medicine in development of human medicine The study aimed to evaluate the therapeutic efficacy of pomegranate peel and leaves of both thuja and tobacco in 5 cows, 15 sheep and 15 goats were brought to veterinary clinics on the outskirts of Baghdad suffering from health problems in the skin, upper respiratory tract and digestive system. Cases were treated topically or orally as a powder, aqueous solution, or ointment. The results showed that 66% of cases were cured. The cure rate was related to the severity of the infection or lesion, course of treatment, routes of administration and herbal formula. Also, the results did not show any side effects of the herbal during the treatment period. Pour- on using of tobacco leaf infusion for lice-infected goats gave a better result than in sheep. The thuja and peels of pomegranate have proven to healing as an ointment for wounds, sores and blisters. Also, the aqueous solution or powder of thuja and peel of pomegranate have proven effective in reducing symptoms in the digestive system and upper respiratory disorders. Both ointments of thuja and pomegranate gave acceptable results for the treatment of warts (papilloma). Therefore, the farmer can use these herbs in emergencies. Recommendation is conducting more clinical veterinary studies on pomegranate, thuja, and tobacco leaves and their medicinal propriety. Thus, the field of veterinary medicine is the best field for reviving biopharmaceutical research and comparative medicine.
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Kamaltdinov, M. R. "Modeling of enzymatic processes in the duodenum to predict areas with elevated risks of functional disorders". Health Risk Analysis, nr 3 (wrzesień 2022): 182–91. http://dx.doi.org/10.21668/health.risk/2022.3.18.
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The present work focuses on developing a model of the duodenum considering motility, biochemical reactions occurring under effects produced by secreted digestive juices, and absorption of reaction products in normal conditions and in case of functional disorders. Analysis of literature sources allowed identifying basic bile components and pancreatic and intestinal juice enzymes influencing fats, proteins and carbohydrates that enter the duodenum. The paper provides a simplified scheme showing how food components are transformed allowing for the neural-humoral mechanism of digestion regulation. Chyme that enters the duodenum is considered a homogenous mixture, which changes its composition during chemical reactions. Mathematical tasking includes mass and momentum conservation equations for a multi-component viscous fluid. The secretion of digestive juices and absorption of components resulting from chemical reactions are described with mass effluents in a pipe in the wall layer. The peristaltic law of the duodenum wall movement was applied to describe the tract motility; the movement characteristics do not depend on the composition of the mixture. Numeric experiments produced necessary results to describe the hydrolysis of the 5 % starch solution under exposure to pancreatic amylase. Obviously, not all the amount of starch enters a chemical reaction and this is well in line with experimental data. The paper provides data on concentration fields for the components of glucose, amylase, and starch at different moments in time and the fluid velocity field. The next stage in the model development is expected to consider absorption of food components, functional disorders of secretion / absorption and intestinal motility as well as influence exerted by neural and humoral mechanisms. In future, the developed model can be applied to predict areas with elevated risks of developing functional disorders, ulcer formation, and other defects of the intestinal mucosa. This will help a physician to prescribe personified therapy and diet.
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Osadchuk, M. A., A. A. Svistunov, N. V. Kireeva i M. M. Osadchuk. "Functional diseases of the gastrointestinal tract in the context with overlapping functional disorders: current status of the problem". Terapevticheskii arkhiv 92, nr 2 (27.04.2020): 111–18. http://dx.doi.org/10.26442/00403660.2020.02.000458.
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Functional diseases of the gastrointestinal tract cause significant damage to the health care system. Their frequent combination in the same patient with the migration of clinical symptoms throughout the digestive tube is accompanied by continuous exacerbations, refractory to the therapy and severe psychosocial disorders. This review provides data on the main etiopathogenetic factors, clinical manifestations, course features and management tactics for patients with overlapping for the most common functional diseases of the gastrointestinal tract.
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Toma, Laura, Mariana Deleanu, Gabriela Maria Sanda, Teodora Barbălată, Loredan Ştefan Niculescu, Anca Volumnia Sima i Camelia Sorina Stancu. "Bioactive Compounds Formulated in Phytosomes Administered as Complementary Therapy for Metabolic Disorders". International Journal of Molecular Sciences 25, nr 8 (9.04.2024): 4162. http://dx.doi.org/10.3390/ijms25084162.
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Metabolic disorders (MDs), including dyslipidemia, non-alcoholic fatty liver disease, diabetes mellitus, obesity and cardiovascular diseases are a significant threat to human health, despite the many therapies developed for their treatment. Different classes of bioactive compounds, such as polyphenols, flavonoids, alkaloids, and triterpenes have shown therapeutic potential in ameliorating various disorders. Most of these compounds present low bioavailability when administered orally, being rapidly metabolized in the digestive tract and liver which makes their metabolites less effective. Moreover, some of the bioactive compounds cannot fully exert their beneficial properties due to the low solubility and complex chemical structure which impede the passive diffusion through the intestinal cell membranes. To overcome these limitations, an innovative delivery system of phytosomes was developed. This review aims to highlight the scientific evidence proving the enhanced therapeutic benefits of the bioactive compounds formulated in phytosomes compared to the free compounds. The existing knowledge concerning the phytosomes’ preparation, their characterization and bioavailability as well as the commercially available phytosomes with therapeutic potential to alleviate MDs are concisely depicted. This review brings arguments to encourage the use of phytosome formulation to diminish risk factors inducing MDs, or to treat the already installed diseases as complementary therapy to allopathic medication.
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Dynnik, V. O., N. V. Bagatska, O. O. Dynnik, O. G. Verchoshanova i H. O. Havenko. "Comorbid pathology issues in pediatric gynecology". Modern pediatrics. Ukraine, nr 8(128) (28.12.2022): 32–36. http://dx.doi.org/10.15574/sp.2022.128.32.
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The problems of diagnosis, therapeutic tactics and medical prognosis in comorbid, polymorbid pathology stand out among the most actual problems of modern health care. Purpose - to study the frequency and nature of comorbid conditions in patients with pubertal abnormal uterine bleeding (PAUB). Materials and methods. The study included 342 girls aged 11-17 suffering from PAUB. All patients were examined by a multidisciplinary team of doctors. Results. It has been shown that menstrual irregularities are combined with other somatic, mental and endocrine pathologies in the vast majority of patients. Only 9.6% of the patients examined had no concomitant pathologies. More than half of girls have a combination of more than three comorbidities. The first three ranks are occupied by endocrine, mental and digestive system disorders. More than a third of patients with endocrine disorders had deviations in terms of body weight - overweight and obesity, which is much more often accompanied by changes in carbohydrate and lipid metabolism. In patients with mental disorders astheno-neurotic syndrome and vegetative-vascular dystonia syndrome prevailed. Functional disorders of the biliary tract were mainly recorded among the disorders of the digestive system, about 18% of girls suffered from gastritis, cholecystitis. The presence of comorbid pathology reduced the effectiveness of non-hormonal therapy by 1.5 times and increased the number of relapses by 3.5-4 times. The effectiveness of non-hormonal therapy was 81.8% on the absence of concomitant pathology; relapses were recorded only in 16.7%. Conclusions. Comorbid pathologies in patients with PAUB aggravate the severity of the girl’s condition, reduces adaptive capabilities, adversely affects the effectiveness of non-hormonal therapy, contributes to the recurrence of the disease and is a risk factor for the development of serious metabolic, endocrine and cardiovascular diseases in the future. The category of patients with concomitant pathology requires a special examination algorithm and the appointment of an adequate therapeutic intervention, taking into account all the identified nosological forms and drug compatibility. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of all participating institutions. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the authors.
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Terehov, Andrew S., i Maxim Yu Yakovlev. "Mathematical Modeling of the Risks of Stress-Related Diseases: a Review". Bulletin of Rehabilitation Medicine 22, nr 4 (25.12.2023): 159–66. http://dx.doi.org/10.38025/2078-1962-2023-22-4-159-166.
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INTRODUCTION. Stress is one of the risk factors for chronic non-communicable diseases, such as cardiovascular diseases, autoimmune disorders, mental disorders, and neurotic conditions like depression and anxiety. Therefore, it is important to predict and correct stress-related problems early.
AIM. To assess the impact of stress on the human body, a comprehensive review of both Russian and international sources was conducted across databases like PubMed, eLibrary, and CyberLeninka for the period 2011–2023. The search terms used included “stress effect”, “predictive model”, “mathematical modeling”, “stress”, “mathematical model”, and “stress-related diseases”.
CONCLUSION. The literature review has revealed that chronic stress exerts a significant negative impact on the human body, verifiably leading to disorders of the digestive, nervous, endocrine, cardiovascular, and immune systems. At the current stage, stress diagnosis is conducted using both questionnaire methods and instrumental techniques, each having its respective advantages and limitations. Several scientific studies emphasize the importance of mathematical modeling as a tool for simulating the effects of stress on the body and analyzing the key mechanisms predisposing to the development of pathologies. The algorithms for constructing predictive models presented in this publication may serve as a foundation for the development of an automated expert advisory system.
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Sequeira, Sonia, i Mahiuddin Ahmed. "Meditation as a Potential Therapy for Autism: A Review". Autism Research and Treatment 2012 (2012): 1–11. http://dx.doi.org/10.1155/2012/835847.
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Autism is a chronic neurodevelopmental disorder of unknown cause that affects approximately 1–3 percent of children and four times more boys than girls. Its prevalence is global and its social impact is devastating. In autism, the brain is unable to process sensory information normally. Instead, simple stimuli from the outside world are experienced as overwhelmingly intense and strain the emotional centers of the brain. A stress response to the incoming information is initiated that destabilizes cognitive networks and short-circuits adequate behavioral output. As a result, the child is unable to respond adequately to stimulation and initiate social behavior towards family, friends, and peers. In addition, these children typically face immune-digestive disorders that heighten social fears, anxieties, and internal conflicts. While it is critical to treat the physical symptoms, it is equally vital to offer an evidence-based holistic solution that harmonizes both their emotional and physical well-being as they move from childhood into adult life. Here, we summarize evidence from clinical studies and neuroscience research that suggests that an approach built on yogic principles and meditative tools is worth pursuing. Desired outcomes include relief of clinical symptoms of the disease, greater relaxation, and facilitated expression of feelings and skills, as well as improved family and social quality of life.
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Klimentov, Mikhail N., S. N. Styazhkina, O. A. Neganova, M. S. Lyubimtseva, E. V. Semibratova i O. D. Turbin. "Crohn’s disease complications, requiring surgical treatment". Perm Medical Journal 36, nr 3 (8.08.2019): 98–105. http://dx.doi.org/10.17816/pmj36398-105.
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Crohn’s disease sickness rate is 0.3–0.2 per 100000 persons, its prevalence is 322 per 100000 persons; Up to 60–70 % of patients with Crohn’s disease undergo this or that type of surgical intervention – from opening of paraproctitis to extensive intestinal resections. Uninterrupted course of disease and probability of severe relapses induce application of long postoperative drug therapy to avoid repeated operations. Repeated resections of the bowel in Crohn’s disease are dangerous from the position of the development of short bowel syndrome, severe digestive disorders. Surgical treatment in Crohn’s disease is aimed at prevention of complications and improvement of patients’ quality of life, if drug therapy is useless.
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Reddy, Raju C., Yibai Hao, Sae-Hong Lee, Srinivasa R. Gangireddy, Chung Owyang i Matthew J. DiMagno. "Pioglitazone reverses insulin resistance and impaired CCK-stimulated pancreatic secretion in eNOS(−/−) mice: therapy for exocrine pancreatic disorders?" American Journal of Physiology-Gastrointestinal and Liver Physiology 293, nr 1 (lipiec 2007): G112—G120. http://dx.doi.org/10.1152/ajpgi.00442.2006.
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In mice, eNOS (endothelial nitric oxide synthase) maintains in vivo pancreatic secretory responses to carbachol or cholecystokinin octapeptide (CCK-8), maintains insulin sensitivity, and modulates pancreatic microvascular blood flow (PMBF). eNOS(−/−) mice are insulin resistant, and their exocrine pancreatic secretion is impaired. We hypothesized that the reduced exocrine pancreatic secretion in eNOS(−/−) mice is due to insulin resistance or impaired PMBF. To test this hypothesis, we gave eNOS(−/−) and wild-type (WT) mice pioglitazone (20 or 50 mg·kg−1·day−1), an insulin-sensitizing peroxisome proliferator-activated receptor-γ (PPAR-γ) activator, and measured pancreatic protein secretion evoked by CCK-8 (160 pmol·kg−1·h−1, a maximal stimulus). We also measured insulin resistance, serum glucose, C-peptide, insulin, pancreatic RNA digestive enzyme expression, and PMBF (microsphere technique). In WT mice, pioglitazone did not increase CCK-8-stimulated protein output over baseline. In eNOS(−/−) mice, however, pioglitazone substantially increased the low CCK-8-stimulated protein output that is characteristic of these mutant mice ( P < 0.005). Pioglitazone abolished the CCK-8-evoked hyperinsulinemia ( P < 0.005) and increased insulin sensitivity of eNOS(−/−) mice ( P < 0.05), the latter based on hyperinsulinemic-euglycemic clamp studies. Pioglitazone had no effect on PMBF or pancreas mRNA expression of insulin or digestive enzymes. We conclude that in hyperinsulinemic eNOS(−/−) mice, a nonobese model of insulin resistance relevant to diabetes mellitus and possibly chronic pancreatitis, reduced pancreatic secretion is caused, at least in part, by insulin resistance. Insulin-sensitizing PPAR-γ agonists such as pioglitazone may thus simultaneously correct endocrine and exocrine pancreatic disorders.
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Dobrescu, Cristina-Elena, i Codruţa Nemet. "The Importance of Objective Clinical Examination in Patients with Trichinellosis, Registered in Braşov County, Between 1983 and 2013". Acta Medica Transilvanica 25, nr 3 (1.09.2020): 7–9. http://dx.doi.org/10.2478/amtsb-2020-0039.
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AbstractIn human trichinellosis, it is important to know the peculiarities of objective manifestations in order to associate the antiparasitic therapy to support the systems and organs affected by this disease. We considered 1112 cases of human trichinellosis recorded between 1983 and 2013 in Braşov County. Objective clinical examinations show that cardiovascular manifestations were most frequent (12.32%). Patients showed these characteristics in the following order: angina, palpitations, and shortness of breath. Digestive disorders were found in 11.27% of the patients. Nine percent of the patients presented respiratory clinical signs. Correlating the objective physical findings with the recorded forms of disease we observe that cardiovascular manifestations prevail in all moderate, moderately severe, severe even in the mild form of the disease. These are followed by digestive and respiratory manifestations that are recorded at high parameters in moderate, moderately severe and severe forms of the disease.