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1
Mannan, Adam James. "Pharmaceutical patents retard pharmaceutical intervention and therapeutic intervention". Thesis, University of Kent, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.580377.
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Patents on pharmaceuticals have emerged from an industry engendered mythology as the sacred heart of pharmaceutical innovation; without patents on pharmaceuticals there will be no new medicines, no wonder drugs and no life saving medical devices.
2
Greenhough, Lynne C. "A therapeutic intervention in a primary school". Thesis, University of Derby, 2018. http://hdl.handle.net/10545/622184.
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As a consequence of interrogating pupil progress data, the primary school in this study identified apparent inequalities in the rates of progress in Reading and Mathematics made by male and female pupils in Key Stage Two cohorts. To address this school improvement issue, the Key Stage Two pupils and the staff who worked with them, were surveyed in order to establish a starting point for action. The surveys indicated that low-achieving female pupils in the school perceived themselves, and were perceived by staff as having low levels of self-esteem and confidence, which were impacting upon their ability to access the learning and impeding their educational progress. A search of the literature on barriers to learning and the range of approaches and initiatives which have been employed to address these, alongside a consultation process with female pupils though a focus group, resulted in identification of the need for the provision of an intervention which would address the issue. Outcomes from an internally–provided school intervention pilot programme resulted in the adoption of a participatory action-research model which allowed the pupils to contribute to the design, implementation and evaluation of a single-sex therapeutic intervention, facilitated by a drama practitioner. Through the use of drama and mask techniques the practitioner provided a safe, non-judgemental environment which enabled participants to feel accepted, to express their feelings, to lead activities, to take risks and to develop a wider friendship circle. The intervention was widely commended, with staff and parents/carers reporting a perceived increase in levels of confidence, expanded friendship circles and stronger peer relationships and improved active engagement in learning in the mixed-gender classroom environment. Qualitative data, in the form of individual video evaluations of the intervention indicated the learning which had resulted from participation, most strongly evidenced by the positive comments elicited from the participants both in terms of the techniques employed in the intervention and the outcomes achieved: “…At first you’re the one underneath the mask… Then the mask becomes you… The masks helped me feel more confident …When we did the mask it was like a confidence builder – made you speak your mind and gave you the words to express your feelings better – like if your excited or happy you had the words to say that…this project helped all our group…’cos we’ve learned to be more confident in ourselves and I just feel a lot better…”
3
Bailey, Liane O. "An intervention strategy to enhance therapeutic exercise adherence". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape3/PQDD_0011/MQ53084.pdf.
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Woodfine, Lynne. "An investigation of therapeutic intervention in reperfusion injury". Thesis, University of Newcastle Upon Tyne, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.361560.
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Hart, P. E. "Human mitochondrial disease : from pathogenesis to therapeutic intervention". Thesis, University College London (University of London), 2005. http://discovery.ucl.ac.uk/1444782/.
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The spectrum of diseases caused by mitochondrial dysfunction is very broad and encompasses the archetypal mtDNA mutation diseases, mutations of nuclear genesencoding mitochondrial proteins (including those of the oxidative phosphorylation system), and a variety predominantly neurodegenerative diseases in which the primary cause of mitochondrial dysfunction remains undefined. The last two decades have seen an explosion in our understanding of the archetypal i mitochondrial disorders. Attention has now focused on the nuclear encoded mitochondrial disorders. Furthermore, nuclear factors may be of significance in the pathogenesis of the archetypal disorders associated with mitochondrial DNA mutations. These conditions are typified by their clinical diversity and poor phenotype-genotype correlation. One of several potential explanations for this is that nuclear genes determine the fate of mtDNA mutations, or that secondary mtDNA mutations have a modulating effect upon the expression of the primary mutation. In this thesis I have sought to address several aspects of the biochemical and clinical features of mitochondrial diseases. In chapter 3 cell cybrids have been used to study the role of the nuclear genome on the biochemical expression of mtDNA mutations in an attempt to understand potential influences on phenotypic expression. An extension of this was the use of xenomitochondrial cybrids to analyse nuclear-mitochondrial interactions and the function of the respiratory chain. At the biochemical/clinical interface, skeletal muscle from patients with focal dystonia has been used as a model to investigate the role that mitochondrial dysfunction might play in this movement disorder. Finally, the clinical role of therapy for mitochondrial disorders has been investigated in the context of Friedreich's ataxia (FRDA). Existing rating scales have been assessed and new ones developed to lay a firm foundation for evaluating disease-modifying therapies. These have been piloted in a long term intervention trial for FRDA.
6
Drotsky, Willem Abraham. "Goalsetting as a motivational mechanism for therapeutic intervention". Diss., Pretoria : [s.n.], 2003. http://upetd.up.ac.za/thesis/available/etd-10222004-142201.
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Papadakis, Emmanuel Douglas. "Targeting atherosclerotic endothelium for therapeutic intervention by gene therapy". Thesis, University of Bristol, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.414190.
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Bradley, William Worth. "Therapeutic intervention with suicidal adolescents: A problem-solving approach". W&M ScholarWorks, 1986. https://scholarworks.wm.edu/etd/1539618886.
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The purpose of this study was to investigate the effectiveness of a problem-solving intervention strategy as applied to mildly suicidal adolescents. The population for this study consisted of male and female adolescents aged 14 to 19 who were referred by teachers, counselors, parents or self because of concerns about suicidal behavior. This project was a case study approach focusing on six mildly suicidal adolescents who volunteered from a pool of referrals received during the 1985-1986 school year. Prior to beginning intervention, each student's lethality was assessed by using the Lethality Index which allowed for the identification of those adolescents who were more seriously suicidal. These students were referred to appropriate agencies.;Pre and post assessment which included interview, the IPAT Depression Inventory, the Suicide Probability Scale, the Checklist for Solving Problems in Real Life and the Classroom Performance Profile was conducted by the school psychologist or social worker involved. Each subject received the same intervention strategy which was a problem-solving approach initiated with each student focusing on his/her own personal problems. Each subject was seen at least once a week for six weeks, however, some students were seen more frequently if necessary.;Overall results of this study were considered inconclusive, as there was no overwhelming or statistically significant proof that a problem-solving intervention approach is successful with mildly suicidal adolescents. It was felt, however, that results did indicate that adolescents referred for depression and suicidal concerns also experience weak problem-solving skills. Each subject indicated that they wanted help in learning how to solve their personal problems better.;Subjective reports from post intervention interviews revealed that students felt more confident in confronting future problems, however, results on the problem-solving inventory did not demonstrate growth in this area.;Generalization of results must be made with caution as there were several major limitations to this study. The problem-solving framework, however, does appear to have merit as a structured format for counselors to use when working with suicidal students and their problems.
9
Taylor, Diana L. "A nursing intervention for perimenstrual turmoil : a longitudinal therapeutic trial /". Thesis, Connect to this title online; UW restricted, 1988. http://hdl.handle.net/1773/7235.
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Konnyu, Kristin Julianna. "Dance as a therapeutic intervention : physical therapists' beliefs and practices". Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/1595.
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Background: Activity and exercise that are sustainable are essential for maximizing their long-term health and therapeutic benefits. Physical therapists (PTs), as clinical exercise specialists, are committed to the exploitation of these benefits. Dance is often perceived as social and enjoyable, both potentially motivating factors that could contribute to its being such a sustained activity.
Purpose: To describe the beliefs and practices of PTs regarding the use of dance as a therapeutic intervention for individuals at risk of or experiencing one or more chronic lifestyle conditions. A secondary aim was to establish an appropriate estimate of statistical power and effect size for subsequent survey or intervention studies.
Design: Descriptive study based on a self-administered questionnaire.
Subjects and Methods: A 5-page survey questionnaire, comprised of 67 items was developed and pre-tested prior to distribution to 231 PTs (with an anticipated response rate of 40%). Public and private practitioners were randomly sampled from the 2008 list of registered PTs in British Columbia. The randomized population was contacted up to five times according to Dillman’s method.
Results: The survey resulted in 136 returned questionnaires (124 returned by respondents, 12 returned undeliverable) resulting in a response rate of 57%. Respondents expressed moderate to high agreement that dance could positively impact clients’ physiological and psychological states. Although most respondents did not prescribe dance, they expressed interest in doing so. Finally, the majority of respondents were amenable to the inclusion of dance in physical therapy practice, professional development education, and research. Rather than inclusion in entry-level education however, most respondents believed dance should be a post-graduate education topic.
Discussion and Conclusion: We believe that this is the first study designed to examine the beliefs and practices of PTs with respect to use of dance as a therapeutic intervention. PTs appear responsive to recommending dance as an activity alternative, and are interested in learning more about its use as a therapeutic intervention and/or health promotion activity. Notably, dancing’s perceived social and enjoyable features were cited by PTs as potential facilitating factors that could sustain long-term participation and corresponding health benefits.
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Youssefpour, Hamed. "Mathematical Modeling of Cancer Stem Cells and Therapeutic Intervention Methods". Thesis, University of California, Irvine, 2013. http://pqdtopen.proquest.com/#viewpdf?dispub=3557204.
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We develop a multispecies continuum model to simulate the spatiotemporal dynamics of cell lineages in solid tumors is discussed. The model accounts for protein signaling factors produced by cells in lineages, and nutrients supplied by the microenvironment. We find that the combination therapy involving differentiation promoters and radiotherapy is very effective in eradicating such a tumor. We investigate the effect of production of various feedback factors by healthy tissue on tumor morphologies. Our simulation results show that the larger production rate of the negative feedback factor by healthy tissue surrounding the tumor, in general lead to smaller, more compact and more circular tumor shapes. However, the increase in the concentration of these feedback factors may have non-monotone effect on the tumor morphologies. We investigate the effect of initial shape on therapy effectiveness. The results from the simulations show that the initial tumor geometry might play an important role in tumor prognostic and the effectiveness of a specific treatment. We observe that the therapy is more effective on tumors that still respond to the signals received from the healthy tissue in comparison with the ones that do not respond to signaling factors (in this case differentiation signals) by stromal tissue or healthy tissue surrounding the tumor. It is shown that the tumors with larger shape factors and smaller areas (more elongated and thinner) respond better to treatment, and the combination therapy is more successful on tumors with such characteristics. We applied mathematical modeling of radiotherapy using experimental data provided from our collaborative work with radiational oncology department of University of California, Los Angeles. Our investigations show that in order to match the experimental results with the simulations, the dedifferentiation rate of non-stem cells should be increased as a function of radiation dose. It is also observed that the population of induced stem cells followed such exponential relationship with respect to therapy dose. The results from simulations and the analysis of the equations suggest that in order for the simulation results to match with the experimental data, the original stem cells and the induced stem cells may undergo direct differentiation.
12
McCarthy, D. J. "Therapeutic policing? : early intervention, anti-social behaviour and social control". Thesis, University of Surrey, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.549462.
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Islam, Md Rezaul [Verfasser]. "Epigenetic Biomarker and Therapeutic Intervention for Dementia / Md Rezaul Islam". Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2021. http://d-nb.info/1225121604/34.
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Riley, J. S. "Post-translational modifications of c-FLIP : opportunities for therapeutic intervention". Thesis, Queen's University Belfast, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.680500.
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FLIP is an anti-apoptotic protein over expressed in multiple types of cancer, including non-small cell lung cancer and associated with drug resistance and poor prognosis. Histone deacetylase inhibitors (HDACi) are identified as a class of drug which down-regulate FLIP expression in NSCLC and induce apoptosis in a FLiP-, caspase-8- and death receptor-dependent manner. Rational combinations of HDACI with the chemotherapeutic cisplatin or TRAIL are result in synergistic cell death in non-small cell lung cancer cell line models but not in normal lung fibroblast cells. More selective HDACi elicited equal or greater responses as pan-HDACi. FLIP down-regulation in response to HDACi occurs via the ubiquitin-proteasome system (UPS). Fundamental biology of FLIP's ubiquitination is examined, including identifying FLIP's ubiquitination at the death inducing signalling complex (DISC). FLIP's ubiquitination is mediated by Iysines 192 and 195 as well as phosphorylation of serene 193. The conjugation of a ubiquitin moiety to a substrate is mediated by E3 ligases, and the removal of ubiquitin is dependent on deubiquitinating enzymes. Two screens were performed to identify novel E3 ligases and DUBs which regulate FLIP's stability and ubiquitination. From these we identified potential candidates. These were validated and appear to be bona fide regulators of FLIP's ubiquitination. Better understanding of the fundamental biology of FLIP has the potential to open new avenues for therapeutic intervention for cancer treatment.
15
Fabia, Renata. "Ulcerative and experimental colitis pathophysiology as basis for therapeutic intervention /". Lund : Dept. of Surgery, Lund University, 1993. http://catalog.hathitrust.org/api/volumes/oclc/39798563.html.
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Lewington, Philippa J. "Rational hypnotherapy : a therapeutic intervention for anxiety neurosis and panic attacks". Thesis, University of British Columbia, 1987. http://hdl.handle.net/2429/26866.
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The efficacy of a rational hypnotherapeutic intervention for anxiety states and panic attacks is the focus of this research.
Based on a single subject research design, the co-researcher was asked to complete pre-therapy, during and post-therapy assessments of personality, self-concept, mood states, stress and physiological symptoms. The baseline period was two weeks and therapy lasted 13 weeks. There were two weeks of post-therapy measures and finally a six-month follow-up study.
The intervention was comprised of progressive relaxation, guided imagery, a cognitive restructuring and behaviour rehearsal based on an A-B-C-D-E paradigm. The subject examined her self-defeating or irrational thoughts in critical incidents and her subjective emotional behavioural and physiological reactions. She was then asked to substitute her own new more rational thoughts in the same situation.
Post-therapy results from the objective tests and self-reports demonstrated significant improvement in almost all areas. Following the rational hypnotherapeutic intervention the co-researcher showed a normal personality profile, increased self-concept, improvement in mood states and a significant reduction in stress and physiological symptoms. This improvement was maintained in the six-month follow-up.
Rational hypnotherapy is effective, relatively short-term and encourages the client to play an active role in finding new ways to deal effectively with problems and accept control over his/her own life.Education, Faculty of
Educational and Counselling Psychology, and Special Education (ECPS), Department of
Graduate
17
Loh, Li Cher. "Immunomodulatory therapy in asthma". Thesis, King's College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391633.
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Abbey, Erica. "Informed consent as a therapeutic intervention: tailoring expectations to maximize recovery". Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=110633.
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Informed consent is an integral component of modern medicine; however, gaps between ethical objectives and psychological corollaries linger. Despite mounting evidence to demonstrate its impact on human behavior, physicians and bioethicists scantily construe it as a source of therapeutic influence. Here we explore judicious ways to leverage this standard-of-care tool as both an ethical requisite in the clinical milieu and a procedure, which could either bolster or deflate the health of individuals, perhaps through a placebo effect.First, in a literature review, we examine the history and components of the informed consent process, and its relation to bioethical principles and patient-practitioner models. We explore relevant psychological mechanisms, such as the placebo and nocebo effect, that are inherent in consent discussions as well as in clinical practice. Applying this information, we offer an attractive recommendation that not only harmonizes the sometimes-clashing bioethical principles of autonomy and non-malfeasance, but also serves as an intervention to improve therapeutic outcome. Further, the review explains the ethical concerns embedded in placebo use, such as deception, abuse of trust, and manipulation, and shows how using the informed consent to elicit a placebo effect withstands ethical scrutiny.Second, we investigate if the informed consent process may actually function as a therapeutic, autonomous intervention. We tested if suggestions given during the informed consent procedure could elicit a placebo effect that would influence the postoperative experience of patients undergoing third molar extractions. Results from this randomized controlled pilot study at the Jewish General Hospital in Montreal indicated that slightly modifying consent form information and tenor decreased overall symptom severity scores on the Postoperative Symptom Severity Scale for experimental subjects compared to controls, as well as overall pain scores on the McGill Pain Questionnaire. Our findings suggest that altering expectations during the informed consent discussion may minimize manifested symptoms experienced post-surgically.Lastly, we study the risk factors often considered to influence postoperative recovery following third molar extractions. The analysis included patients' preoperative expectations as a determinant for the severity of postsurgical pain. Standardized coefficients demonstrated that out of age, gender, number of teeth removed, difficulty of extraction, operation time, intervention, and patient expectations, the latter was the largest significant predictor of postoperative pain scores. These results demonstrate that preoperative expectations are of utmost importance when predicting and determining the severity of patient recovery.Bien que le consentement éclairé soit une partie intégrante de la médecine contemporaine, un fossé entre les objectifs éthiques et les connaissances psychologiques demeure présent. En effet, malgré l'accumulation de preuves scientifiques démontrant l'influence du formulaire de consentement sur le comportement humain, les médecins et bioéthiciens considèrent rarement ce dernier comme ayant un impact thérapeutique. Nous explorons ici la possibilité de percevoir cette norme de diligence comme étant à la fois une obligation éthique du milieu clinique et une procédure thérapeutique pouvant, probablement par le biais d'un effet placebo, aider ou nuire à la santé de l'individu.En premier lieu, dans une revue de la littérature nous examinons l'historique et les composantes du processus de consentement éclairé et étudions comment ce dernier correspond aux principes de la bioéthique et aux modèles de relation entre les patients et les professionnels de la santé. Nous explorerons également les mécanismes psychologiques importants dans le processus de consentement et dans la pratique clinique, comme par exemple les effets placebo et nocebo. Mettant en pratique cette information, nous proposons une attirante suggestion dans l'utilisation du processus de consentement éclairé qui promet de rééquilibrer l'harmonie entre les principes éthiques d'autonomie et de non-malfaisance, lesquels ont tendance à s'affronter dans l'utilisation traditionnelle de ce processus. Notre suggestion servira également d'intervention qui aidera au processus de guérison. Enfin, la revue littéraire expliquera les préoccupations éthiques comprises dans l'utilisation des placebos, comme par exemple la déception, l'abus de confiance et la manipulation, puis détaillera en quoi l'utilisation de l'effet placebo dans le processus de consentement contrebat ces problèmes éthiques.En second lieu, nous cherchons à savoir si le processus de consentement éclairé peut effectivement fonctionner comme une intervention thérapeutique autonome. Plus précisément, nous avons testé si des suggestions administrées au cours du processus de consentement peuvent produire un effet placebo influençant l'expérience thérapeutique de patients suite à l'extraction chirurgicale des troisièmes molaires. Nous avons menée cette étude à l'Hôpital Général Juif de Montréal et avons utilisé un échantillonnage aléatoire afin de s'assurer de la validité des résultats. Les résultats de cette étude pilote indiquent qu'une légère modification de l'information et de la teneur générale du formulaire de consentement suffit pour réduire la sévérité des symptômes évalués sur l'échelle de sévérité des symptômes postopératoires [Postoperative Symptom Severity Scale], ainsi que pour réduire les indices de douleur du Questionnaire sur la douleur de McGill [McGill Pain Questionnaire]. En effet, nos résultats démontrent qu'une modification des attentes des patients lors du processus de consentement peut éliminer, ou du moins réduire, les symptômes reliés à l'expérience postopératoire.Finalement, nous étudions les facteurs de risque souvent considérés comme ayant un impact sur la guérison suite à l'extraction chirurgicale d'une troisième molaire. L'analyse incluait les attentes des patients concernant la sévérité des symptômes post-chirurgicaux. Des coefficients standardisés ont indiqué que, parmi les variables étudiées (âge, sexe, nombre de dents extraites, difficulté de l'extraction, temps d'opération, intervention et attentes des patients), les attentes des patients sont les meilleurs prédicteurs des résultats postopératoires. Ces résultats démontrent l'importance des attentes préopératoires sur la prédiction des symptômes et de leur sévérité chez des patients en rémission chirurgicale.
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Grig, Andrew. "Novel strategies for the therapeutic intervention of human immunodeficiency virus infection". Thesis, Imperial College London, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.252346.
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Stewart, J. Wade. "A Pilot Study of Solution-focused Brief Therapeutic Intervention for Couples". DigitalCommons@USU, 2011. https://digitalcommons.usu.edu/etd/1061.
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Over the years, many interventions have been used to ameliorate couple distress and increase relationship satisfaction. These interventions have been getting shorter in duration. The purpose of this pilot study was to test the feasibility and impact of a brief intervention using a solution-focused approach (SFBT) for couples. The brief intervention included two two-hour consultations. Data were collected from 30 couples and were analyzed using a repeated measures design. The analyses yielded mixed results. There were statistically significant improvements in the areas of individual well-being and relationship knowledge. There were no significant differences in terms of marital satisfaction, communication skills, and readiness to change, although positive trends were observed in this pilot phase. Implications for future research and development are discussed.
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Burton, Christopher Richard. "Therapeutic nursing practice in stroke rehabilitation : the development and evaluation of a therapeutic nursing intervention in stroke rehabilitation". Thesis, University of York, 2002. http://etheses.whiterose.ac.uk/9871/.
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Nelson, Mara Hendricks. "A pilot study to examine a therapeutic exercise intervention on fibromyalgia symptoms". BYU ScholarsArchive, 2006. https://scholarsarchive.byu.edu/etd/398.
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Objective. To examine the feasibility of a home-based, video therapeutic exercise program on pain, fatigue, self-efficacy, and health status in fibromyalgia patients. Methods. Nine individuals who were previously diagnosed with fibromyalgia completed the study (out of an initial pool of 31). Subjects were randomly assigned to one of two groups: a group who received a home-based therapeutic exercise video and a control group who continued to undergo their current standard of care or "treatment-as-usual." The video group was instructed to conduct the exercises as prescribed in the 42-minute video at least 3 times per week for 4 weeks. The treatment-as-usual control group was instructed to continue to undergo their current standard-of-care and to not begin any new treatments during that time. Instruments measuring self-efficacy, pain, fatigue, self-rated health status and health distress were administered at baseline and 4 weeks. Results. None of the variables analyzed showed a significant change between the treatment and control groups over the course of the 4-week study. Conclusion. This study was not sufficiently powered to detect differences between the two groups. However, several of the treatment group participants subjectively indicated that they found the exercises to be helpful in the management of their fibromyalgia symptoms and the program did not exacerbate any of their symptoms. With this information, it appears that patients are able to tolerate the treatment and are able to complete the outcome measures. Between-group clinical outcomes will now need to be assessed in a larger clinical trial.
23
Macdonald, Wendy Jane. "The role of positive emotions within parenting interventions as part of therapeutic change". Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/the-role-of-positive-emotions-within-parenting-interventions-as-part-of-therapeutic-change(2f47f89c-1d78-4bac-bfec-5ceb6abaa4a0).html.
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This thesis has considered findings from evaluations of parenting programmes which have traditionally used outcome measures of negative affect and behaviour to measure change. Drawing on the considerable body of research on parenting programmes and their theoretical basis Paper 1 advances a line of argument about the potential for incorporating measures developed from research in the area of positive psychology. Extending outcomes of interest to incorporate measures of positive affect, attitudes and behaviour has the potential to contribute to our understanding of the mechanisms of change. No studies of parenting programmes using positive outcome measures were identified. Paper 1 concludes that future research of parenting programmes could begin to investigate the role of positive emotions as mechanisms of change. Paper 2 aimed to examine session-by-session changes in gratitude, positive and negative affect, satisfaction, authenticity, self-efficacy, defeat and entrapment in parents attending a Triple P Positive Parenting program. This study found that entrapment had a significant concurrent relationship with gratitude, negative and positive affect, authenticity, and satisfaction with life. Entrapment was also found to be a significant predictor of session by session change with lower levels of entrapment predicting increases in gratitude, negative and positive affect, and satisfaction. The study concludes that reductions in entrapment are a significant predictor of increases in positive affect and attitudes in carers attending a parenting programme. Paper 3 is a critical reflection and considers both Paper 1 and Paper 2. Within this paper the approaches used, the challenges encountered, and future research are considered.
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Lo, Ka-yee, i 勞嘉儀. "Therapeutic play intervention in promoting psychological well-being inhospitalized children with cancer". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43251389.
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Zoubi, Salha A. "The effects of experimental diabetes and therapeutic intervention on rat intestinal epithelium". Thesis, University of Nottingham, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.259857.
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Taylor, Carol. "The quality of therapeutic alliance in a parent-mediated intervention for autism". Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/the-quality-of-therapeutic-alliance-in-a-parentmediated-intervention-for-autism(8ab65024-f956-4642-9c0f-40780924ffc7).html.
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Background: Interventions for young children with autism are increasingly delivered through parents. This thesis investigated baseline and process variables associating with quality of parent-therapist alliance in a parent-mediated intervention for autism, including variables relating to parents' causal beliefs and perspectives. Participants: 77 parents and 6 therapists from a RCT of a parent-mediated intervention for autism (PACT). Method: A sequential exploratory mixed methods approach, with an intermediary instrument development phase. Baseline variables, investigated for the full sample of 77 cases, comprised demographic variables, parental dichotomous causal belief variables, and a therapist average fidelity variable. Thematic analysis of intervention session transcripts informed the development of the Parental Perspectives Coding Scheme (PPCS), a video-based scheme for rating the quality of parent 'Expression' and therapist 'Integration' of parental perspectives during intervention. 5 overarching themes were initially identified, these were collapsed into three items for the PPCS; Interpretation of the Child (IOC), Parent Actions and Strategies (PAS) and Parental Self Disclosures (PSD). Item inter-rater reliabilities were satisfactory to good. Parent-therapist dialogue, for a sub-sample of 20 cases, was coded using the PPCS to create process variables for the Expression and Integration of parental perspectives. Initial analyses identified baseline and process variables with significant univariate associations with alliance; these were included in separate multivariate models of parent-rated alliance and therapist-rated alliance. Results: Parent-rated and therapist-rated alliance did not correlate. PPCS Expression and Integration scores were higher in the high parent-rated alliance group but the difference was non-significant. Parents who cited MMR as a possible cause of their child's autism rated the alliance significantly lower than those who did not. Parents with no post-16 qualifications rated the alliance significantly higher than those with higher qualifications. Each factor contributed independently to a multiple regression model, together explaining 18.3% of variance in parent-rated alliance. Therapist-rated alliance significantly correlated positively with therapist fidelity and with PPCS variables for parent Expression and therapist Integration; together these explained 58.8% of variance in therapist-rated alliance. Conclusions: Therapists should be aware that parents may rate the alliance differently from themselves and that different factors associate with their ratings. Parents' causal beliefs and level of education may influence their ratings of alliance in specific interventions.
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Maclean, Georgina. "Exploring children's writing during a therapeutic storytelling intervention : a mixed methods study". Thesis, University of Southampton, 2013. https://eprints.soton.ac.uk/359458/.
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Emotional difficulties in children and young people are associated with poor behavioural, social and educational outcomes (Kern, Hilt-Panahon & Sokol, 2009). A systematic review was carried out to explore the effects of therapeutic writing interventions on students’ emotional and academic outcomes and to develop an understanding of the underlying mechanisms that might help to explain these effects. Therapeutic writing interventions were found to be effective in reducing symptoms of stress, depression and anxiety and were related to improvements in academic performance. Underlying mechanisms that were associated with positive outcomes included changes in cognition, improvements in coping strategies and improvements in working memory capacity. The review highlighted a lack of research exploring the effects of therapeutic writing techniques on academic outcomes with younger students. The empirical paper sought to address some of the gaps in the existing research highlighted in the review. The research utilised a sequential explanatory mixed methods design to investigate the effects of a therapeutic storywriting intervention on children’s writing. The first quantitative phase consisted of two studies. The first study investigated the effects of a therapeutic storywriting intervention on children’s writing achievement in comparison to a matched control group. The intervention group (n=28) made significantly greater academic gains compared to the control group (n=28). The second study examined to what extent the intervention facilitated cognitive changes through exploring changes in children’s use of written language during the therapeutic storywriting intervention. There were some significant changes in children’s use of emotional and causal words; however these did not significantly predict greater academic gains. In the second qualitative phase, narrative analysis was used to explore and compare the stories written by children who had made the most and least gains. There were a number of similarities between both groups’ stories; however more of the stories written by children who had made the least gains ended negatively and lacked helpful secondary characters. The quantitative and qualitative findings are discussed with reference to prior research.
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Yang, Kun. "Targeting Cancer-Associated Fibroblasts: New Opportunity for Therapeutic Intervention in Cutaneous Melanoma". University of Cincinnati / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1521191527381948.
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Bates, Sarah H. "Investigation of potential intervention targets to improve insulin action: a therapeutic approach". Thesis, Aston University, 1999. http://publications.aston.ac.uk/10980/.
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Impaired insulin action (insulin resistance) is a key factor in the pathogenesis of diabetes mellitus. To investigate therapeutic targets against insulin resistance, this thesis explores the mechanism of action of pharmacological agents and exogenous peptides known or suspected to modify insulin action. These included leptin, a hormone primarily involved in the regulation of body weight; sibutramine, an antiobesity agent; plant-derived compounds (pinitol and chamaemeloside) and agents known to affect insulin sensitivity, e.g. metformin, tolbutamide, thiazolidinediones, vanadyl sulphate and thioctic acid. Models used for investigation included the L6 skeletal muscle cell line and isolated skeletal muscles. In vivo studies were undertaken to investigate glycaemia, insulinaemia, satiety and body weight in streptozotocin-induced diabetic mice and obese (ob/ob) mice. Leptin acutely altered insulin action in skeletal muscle cells via the short form of the leptin receptor. This direct action of leptin was mediated via a pathway involving PI 3-kinase but not Jak2. The active metabolites of sibutramine had antidiabetic properties in vivo and directly improved insulin sensitivity in vitro. This effect appeared to be conducted via a non-PI 3-kinase-mediated increase in protein synthesis with facilitated glucose transport, and was independent of the serotonin and noradrenaline reuptake inhibition produced by sibutramine. Pinitol (a methyl inositol) had an insulin mimetic effect and was an effective glucose-lowering agent in insulinopenic states, acting directly on skeletal muscle. Conversely chamaemeloside appeared to improve glucose tolerance without directly altering glucose transport. Metformin directly increased basal glucose uptake independently of PI 3-kinase, possibly via an increase in the intrinsic activity of glucose transporters. Neither tolbutamide nor thiazolidinediones directly altered insulin sensitivity in L6 skeletal muscle cells: however vanadyl sulphate and thioctic acid increased glucose transport but appeared to exert toxic effects at therapeutic concentrations. Examination of glucose transport in skeletal muscle in this thesis has identified various components of post-receptor insulin signalling pathways which may be targeted to ameliorate insulin resistance.
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Nelson, Mara H. "A pilot study to examine a therapeutic exercise intervention on fibromyalgia symptoms /". Diss., CLICK HERE for online access, 2006. http://contentdm.lib.byu.edu/ETD/image/etd1243.pdf.
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Hackney, Madeleine E., Courtney D. Hall, Katharina V. Echt i Steven L. Wolf. "Application of Adapted Tango as Therapeutic Intervention for Patients With Chronic Stroke". Digital Commons @ East Tennessee State University, 2012. https://dc.etsu.edu/etsu-works/553.
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Background and Purpose: Dance has demonstrated beneficial effects on mobility in older individuals with movement disorders; yet, effects of partnered dance remain unexamined in individuals with chronic stroke. The purpose of this study was to describe the effects of adapted tango classes on balance, mobility, gait, endurance, dual-task ability, quality of life (QOL), and enjoyment in an older individual with chronic stroke and visual impairment.
Case Description: D.L. was a 73-year-old African American man, 13 years poststroke with spastic hemiplegia, visual impairment, and multiple comorbidities.
Intervention: D.L. attended 20 1?-hour tango classes adapted for older individuals with sensory and motor impairments over 11 weeks.
Outcomes: Measures of balance, mobility, gait, endurance, dual-task ability, and QOL were evaluated before and after the intervention and at 1-month follow-up. D.L. improved on the Berg Balance Scale, 30-s chair stand, Timed Up and Go (single, manual, and cognitive conditions), 6-Minute Walk Test, and backward gait speed. Not all measures improved: balance confidence decreased, and there was no change in forward and fast gait speed or QOL, as measured by the Short Form-12 and the Visual Function Questionnaire–25. Some gains were maintained at one-month follow-up. D.L. reported enjoying the classes, noted improvement in physical well-being, and wanted to continue the program.
Discussion: Thirty hours of adapted tango lessons improved balance, mobility, endurance, and dual-task ability in a participant with chronic stroke. The participant enjoyed the classes, was adherent, and wished to continue. This is the first reported use of adapted tango dance as rehabilitation for an individual with chronic stroke and low vision.
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Primeaux, Sunni. "A Preliminary Examination of the ACT Matrix as a Brief Therapeutic Intervention". OpenSIUC, 2019. https://opensiuc.lib.siu.edu/dissertations/1731.
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Brief therapeutic interventions are increasingly becoming more popular for a variety of reasons, including cost, insurance reimbursement rates, and time constraints of patients. While several brief interventions exist, most of them still require four to eight hour-long sessions and emphasize symptom reduction. One therapeutic model that differs from traditional cognitive behavioral therapy and focuses more on valued living is Acceptance and Commitment Therapy (ACT; Hayes, Strosahl, & Wilson, 2012). While ACT is a complex treatment package, a therapeutic tool called the ACT Matrix presents the essential elements of ACT in a comprehensive yet brief fashion (Polk, Schoendorff, Webster, & Olaz, 2016) that may be useful in settings requiring brief therapeutic interventions, such as integrated primary care and college counseling centers. However, as the ACT Matrix is a clinician-developed activity primarily used as a component of individual and group therapy, currently there is little empirical research to support its usefulness. The current study examined the impact of the ACT Matrix versus a control group on valued-action, psychological inflexibility, quality of life, and depression and anxiety symptomatology at a one-week follow-up. Consistent with hypotheses, results indicated that the ACT Matrix had a significant impact on increasing valued action, values satisfaction, and quality of life while decreasing depression and anxiety symptomatology, as compared to participants in the control group. Limitations and future directions are discussed.
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Asselstine, Margit E. "Body experiences of women survivors of child sexual abuse, implications for therapeutic intervention". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ41540.pdf.
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Sykes, Michelle. "An Evaluation of the FRIENDS program : A Therapeutic Intervention for Anxious Young People". Thesis, University of Exeter, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.503424.
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The rise in mental health issues in children and adolescents in the U.K has increased the need for evidence based therapeutic interventions. The focus of the research in this thesis was to contribute towards the growing evidence base for effective cognitive-behavioural therapy (CBT) interventions suitable for young people which could be delivered in school settings. This research specifically aimed to evaluate a manual based intervention to address anxiety in young people. The 'FRIENDS for Youth' (Barrett 1998) program was chosen for its existing success in Australia and its strong roots in CBTtheory. The underlying theory behind CBT links back to Bandura's (1986) Social Cognitive Theory. This theory outlines that human behaviour is determined by the reciprocal interaction of three factors; cognitive, behaviour and the environment. Social Cognitive Theory places a strong emphasis on cognition and suggests that an understanding of the cognitive process involved can lead to behaviour being predicted, understood and changed. Bandura (1986) postulated that individuals hold a self-system that provides them with a degree of control over their own thoughts, feelings and actions. Bandura theorised that it was this self-system that contained the cognitive and affective structures and allowed for individuals to learn through observation, plan alternative strategies, regulate and change behaviour and engage in self reflection. Based on this theory, CBT follows the idea that understanding, recognising and restructuring individual cognitions can lead to changing behaviours. Bandura (1986) also felt self reflection was an important component in behaviour change as it led people to evaluate their experiences and alter their own thought processes. These self evaluations include perceptions of self efficacy Le. a person's beliefs about personal competence. Beliefs of efficacy verify the level of effort a person will make in a difficult situation, how long they will persist in overcoming barriers and their level of resilience in facing adverse situations. Greater levels of self efficacy predict greater levels of effort, persistence and resilience. Social cognitive theory also suggeststhat perceived self efficacy plays a central role in anxiety arousal. In threatening situations, perceived coping inefficacy results in high levels of anxiety and distress with anxiety arousal and avoidant behaviour being co-effects of the perceived inefficacy (Bandura, 1989). Even more interesting and indeed of relevance to the research being proposed is Bandura's (1989) notion that efficacy beliefs also influence individual's thoughts processes and emotional reactions. Low levels of self efficacy suggest there is a belief that things are tougher than they actually are which in turn fosters feelings of stress, anxiety and depression which in turn narrows the ability to problem solve. The most effective way to develop self efficacy is to create a strong sense of efficacy through mastery of experiences which are structured to build coping skills and instil beliefs that one can have some control over the situation. Smith, Arkoff & Wright (1989) reported that perceived efficacy predicted improvements in performance and reduced anxiety in his sample of highly anxious students. Bandura, Adams & Beyer (1977) suggested that the impact of therapy upon behaviour change is mediated by the extent to which the individuals acquire the belief they can perform the behaviours to which the therapy is orientated. With that in mind, the focus of this research is to assess the effects, experience and effectiveness ofthe FRIENDS program when used as a targeted therapeutic intervention in a secondary school for a small group of self selected young people with anxiety. Paper 1 focuses on the summative evaluation, looking at the outcome effects the FRIENDS program has on participant's levels of anxiety, self efficacy and well being whilst Paper 2 focuses on the more formative evaluation. This paper looks at the young people's lived experience of the intervention and the meanings and value they placed upon the experience. Together, the results of the research from these two papers allows for an overall evaluation of the FRIENDS program to be made which builds upon the earlier work of Barrett (1998) and the existing success of the FRIENDS program as demonstrated in the Australian literature. The findings of this research not only extend the evidence base towards the impact FRIENDShas on its users but also considers the social validity of the program through examining the users' perceptions of the program. Furthermore, the findings contribute towards discussion regarding the impact the program has and the value of the intervention as a therapeutic intervention which could be used in secondary schools in the U.K. The results of this study found significant reductions in anxiety levels using pre- and postcomparisons. Greatest differences were found for social anxiety, generalised anxiety and oeD. Lasting changes to anxiety levels were maintained at follow up. An increase in social self efficacy was also found although these changes were not found to be significant. No significant changes were found for well being. Significant themes found from the qualitative analysis show that the young people placed value upon the friendships they formed during the intervention, the positive changes they saw in themselves which they attributed to the FRIENDSprogram and the usefulness of the new skills they developed as part of the program. The results of the focus group suggested a high social validity of the FRIENDS program from the participant's direct experience. Together, these findings provide evidence of a wider impact of success that was measured by the outcomes alone in paper 1.The research outlined in this thesis discusses the findings of the two phase evaluation and gives consideration to future direction and areas for further research. Lastly, questions are raised about the role of the educational psychologist and the delivery of therapeutic interventions. This research will be of benefit to educational psychologists and other professionals working with children and young people as a way of raising their awareness of mental health in young people and strengthening the evidence base for FRIENDSas a therapeutic program to be used in practice. Although this research was very small scaled, the findings have made a start at outlining some of the benefits for the use of the FRIENDS program in schools to reduce anxiety. These findings could also be used to contribute towards the development of policy and practice regarding the way anxiety is managed within schools and the accessibility of therapeutic type interventions available to school settings.
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Ball, Stephen Kenneth. "The role of the vacuolar ATPase in disease : new approaches to therapeutic intervention". Thesis, University of Leeds, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.414577.
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Mitropoulou, Alkistis. "Structural studies of IgE as a target for therapeutic intervention in allergic disease". Thesis, King's College London (University of London), 2016. https://kclpure.kcl.ac.uk/portal/en/theses/structural-studies-of-ige-as-a-target-for-therapeutic-intervention-in-allergic-disease(bc898bf4-0ba0-4c23-9b4e-345db91d04d2).html.
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In recent decades, the incidence of allergy, an immune disorder mediated by immunoglobulin E(IgE), has become more common. The symptoms of these allergic diseases not only cause discomfort,but may also be!fatal. Although the aetiology of allergy is debated, it is widely accepted that the interaction of IgE with its high affinity receptor FcεRI plays a pivotal role in the pathogenesis of allergic disease. The current treatments include therapeutics for both the prevention and relief of symptoms, and the intravenously administered omalizumab. The mechanism of action of this anti-IgE antibody, which is a monoclonal IgG antibody, has now been identified. In order to crystallise the omalizumab Fab/IgE-Fc complex, mutagenesis had to be performed on the Fab. This thesis reports six Fab crystal structures, of wild-type and different mutant omalizumab Fabs, and one single-chain variable fragment (scFv). The unbound Fab and! scFv structures were compared with each other (wild-type versus mutants), and also with those in the Fab/IgE-Fc complex in order to identify conformational differences. Potential small-molecule inhibitors for the IgE-FcεRI interaction were screened by X-ray crystallography and Surface Plasmon Resonance analysis. The crystal structures of a grass pollen allergen (Phl p 7) alone and in complex with a Fab fragment of a patient-derived antibody were also determined. The allergen-Fab complex crystals were susceptible to radiation damage. Multiple datasets were collected and careful merging was required to permit determination of the allergen-antibody crystal structure. This revealed that a monomeric allergen, the EF-hand Phl p 7 protein, binds simultaneously to two identical antibodies of the same specificity for Phl p 7. This discovery explains how the binding of a single monomeric allergen molecule can trigger the cross-linking of FcεRI-bound IgE by both a ‘classical’ CDR-mediated, and a framework-mediated, interaction, thereby triggering activation of a mast cell or basophil. This provides valuable new insights concerning the nature of allergenicity, and also informs the engineering of hypoallergenic vaccines for immunotherapy.
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Paudel, Nirmala. "Computational analysis of biochemical networks for drug target identification and therapeutic intervention design". Thesis, Massachusetts Institute of Technology, 2014. http://hdl.handle.net/1721.1/90152.
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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biological Engineering, 2014.Cataloged from PDF version of thesis.
Includes bibliographical references (pages 96-104).
Identification of effective drug targets to intervene, either as single agent therapy or in combination, is a critical question in drug development. As complexity of disease like cancer is revealed, it has become clear that a holistic network approach is needed to identify drug targets that are specially positioned to provide desired leverage on disease phenotypes. In this thesis we develop a computational framework to exhaustively evaluate target behaviors in biochemical network, either as single agent or combination therapies. We present our single target therapy work as a problem of identifying good places to intervene in a network. We quantify a relationship between how interventions at different places in network affect an output of interest. We use this quantitative relationship between target inhibited and output of interest as a metric to compare targets. In network analyzed here, most targets show a sub-linear behavior where a large percentage of targeted molecule needs to be inhibited to see a small change on output. The other key observation is that targets at the top of the network exerted relatively small control compared to the targets at the bottom of the network. In the combination therapy work we study how combination of drug concentrations affect network output of interest compared to when one of the drugs was given alone at equivalent concentrations. By adapting the definitions of additive, synergistic, and antagonistic combination behaviors developed by Ting Chao-Chou (Chou TC, Talalay P (1984), Advances in enzyme regulation 22: 27-55) for our system and systematically perturbing biochemical pathway, we explore the range of combination behaviors for all plausible combination targets. This holistic approach reveals that most target combinations show additive behaviors. Synergistic, and antagonistic behaviors are rare. Even when combinations are classified as synergistic or antagonistic, they show this behavior only in a small range of the inhibitor concentrations. This work is developed in a particular variant of the epidermal growth factor (EGF) receptor pathway for which a detailed mathematical model was first proposed by Schoeberl et al. Computational framework developed in this work is applicable to any biochemical network.
by Nirmala Paudel.
Ph. D.
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Mattis, Virginia B. "Molecular genetics of spinal muscular atrophy insights into various routes of therapeutic intervention /". Diss., Columbia, Mo. : University of Missouri-Columbia, 2009. http://hdl.handle.net/10355/6761.
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Thesis (Ph. D.)--University of Missouri-Columbia, 2009.The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Vita. "May 2009" Includes bibliographical references.
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Lo, Ka-yee. "Therapeutic play intervention in promoting psychological well-being in hospitalized children with cancer". Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B43251389.
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Morrison, Tricia L. "Working Alliance and Functional Outcomes in an Occupational Therapy Intervention: A Cross Case Analysis". Thèse, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/22765.
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This is the first known occupational therapy (OT) study to examine the emergent patterns of the client-therapist working alliance during the course of a community-based OT intervention. The experiences of both the adult client and OT in each of four dyads are explored and described as they relate to the evolution of the alliance over time and the impacting contextual factors. These experiences were considered alongside the therapy outcomes. Mixed methods, including quantitative scales and interviews, were used in this multiple-case study situated within a pragmatism paradigm. Individual case and cross case analyses were conducted leading to the identification of eleven cross case themes. These findings suggest that the interpersonal relationship between a client and OT develops with the goal of becoming a safe harbour for the clients. The strengthening interpersonal bond appears to create an impetus within the client to engage in therapeutic activities. This enticed engagement results in the client’s performance of novel activity purposefully selected by the OT as bearing personal meaning for the client. The clients’ engagement often results in enhanced insight into their abilities and meaningful functional gains. This success appears to reinforce and energize both the momentum toward the collaboratively-established therapy goals, as well as provides a positive feedback mechanism into the working alliance. The OT’s training, philosophy and skill, client’s attributes, and environmental influences (both physical and social) all appear to have potential implications upon the working alliance’s development and/or the therapeutic achievements. Further research will be needed to confirm or disconfirm these findings and may include further study with variable client populations (e.g., different ages, different conditions), the role of humour in the therapeutic process, the impact of client’s degree of social isolation on the alliance, as well therapists’ disparate levels of use-of-self and the related impacts upon the alliance.
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Nguyen, KhanhLinh T. "Design, synthesis and biological evaluation of oxysterol derivatives as potential therapeutic intervention for osteoporosis". Diss., Restricted to subscribing institutions, 2009. http://proquest.umi.com/pqdweb?did=1997737691&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.
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Habibollah, Saba. "Cord and cord blood stem cell tissue engineering for therapeutic intervention in liver disease". Thesis, University of Newcastle Upon Tyne, 2010. http://hdl.handle.net/10443/1064.
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Liver cirrhosis and/or liver malignancies have been nominated as the 5th leading cause of death worldwide. The WHO reported, in 2006, that 20 million people around the globe suffer from some form or other of severe liver illness. The ultimate fate of end-stage liver disorders is hepatic dysfunction and eventually organ failure. The only curative mode of management for liver failure is liver transplantation, which is subject to many limitations. Novel alternatives, such as artificial and bio-artificial support devices only aid in temporary replacement of some liver function until an organ is available for transplantation. These newer modalities also have drawbacks or remain experimental and still demand further controlled trials to allow proof of concept and safety before transferring them to the bedside. Regenerative medicine and stem cell therapy has recently shown promise in the management of various human diseases. Recent reports of stem cell plasticity and its multipotentiality has raised hopes of stem cell therapy offering exciting therapeutic possibilities for patients with chronic liver disease. With the understanding that stem cells might not just be about making organs ex vivo, but also regenerating a patients own tissues; a concept is now developing to use stem cells to treat patients with serious disease conditions that are terminal or where conventional modes of treatment are insufficient. There exists a choice of stem cells that have been reported to be capable of self-renewal and differentiation to hepato-biliary cell lineages both in vitro and in vivo. These include: rodent and human embryonic stem cells, bone marrow haematopoietic stem cells, mesenchymal stem cells, umbilical cord blood stem cells, foetal liver progenitor cell and adult liver progenitor cells. It may, however, be argued that with a global population of 6 billion people and a global birth rate in access of 130 million per year, the products of birth ,umbilical cord and cord blood, possibly provide the most readily accessible and ethically sound alternative source of stem cells. The differentiated stem cells can be potentially exploited for gene therapy, cellular transplant, bio-artificial liver-assisted devices, drug toxicology testing and use as an in vitro model to understand the developmental biology of the liver. In this study UCB-derived nucleated cells and umbilical cord-derived Mesenchymal stem cells were exploited for liver differentiation ex vivo. These cells were cultured on extracellular matrix (ECM) protein-coated dishes and inserted into ECM incorporated scaffold 3D culture systems. Stimulation with exogenous mitogens and morphogens to induce hepatic histogenesis was experimented. Immunofluorescence analysis revealed the expression of markers specific for: hepatic stem cells (CK-19), hepatoblasts (AFP) and 4 mature hepatic and biliary epithelium markers including: albumin (ALB), and cytokeratin- 18 (CK-18) and cytokeratin-19 (CK-19) and cytokeratin-7 (CK-7) respectively. The differentiated cells displayed several features of hepatic cell kinetics and metabolic activities, including glycogen synthesis, uptake of Indocyanine green dye and cytochrome P450 activity. These cells may prove to have potential in developing cellular therapy for various liver disorders for which the current mode of therapy is inadequate and also provide an adequate in vitro model of parenchymal liver cells in toxicology and in bioartificial liver research.
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Williams, Mhairi Elizabeth. "Can sense of coherence predict therapeutic outcome of a brief guided self-help intervention?" Thesis, University of Edinburgh, 2010. http://hdl.handle.net/1842/5504.
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Background: The construct sense of coherence (SOC) is proposed to explain the variation in the way people cope and it has been linked with positive mental health. Evidence suggests that level of SOC may be able to predict therapeutic outcome. There is a lack of evidence regarding individual predictors for treatment response of guided self-help services. Therefore, SOC is an important construct to consider. Objectives: The purpose of this study was to investigate whether a client’s sense of coherence at the start of a guided self-help intervention could predict their therapeutic outcome. The possibility that coping style mediated this relationship was also examined. Method: The study employed a longitudinal survey design. Participants were patients aged 30-64 years attending a guided self-help service for mild-moderate psychological difficulties. Participant data was collected pre and post intervention (3 weeks to 3 months after initial appointment). Results: A significant negative association was found between SOC and pre intervention anxiety and depression scores. No significant relationship was found between SOC and post intervention anxiety and depression scores (therapeutic outcome). Multiple regression analysis found that sense of coherence and coping style were not significant predictors of therapeutic outcome. Conclusions: It is important to determine the causality of SOC’s relationship with mental health because if SOC can be influenced via psychological intervention this may promote positive mental health and effective coping. Therefore, further research is required to determine if SOC has clinical application.
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Frender, Jesse. "Exploring the experience of adult participants in therapeutic enactment, a group-based trauma intervention". Thesis, University of British Columbia, 2014. http://hdl.handle.net/2429/47072.
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Counselling and psychotherapy literature frequently reports that group-based interventions are effective and appropriate for addressing psychological trauma. Predominantly, this literature is grounded in theoretical assumptions about the process of healing trauma, or the clinical experiences and observations of clinicians. Although a small and growing body of empirical outcome studies exists, virtually non-existent are investigations into clients' own experiences of the process of group trauma therapy. On the premise that understanding client perspectives is integral to refining intervention techniques and shaping future empirical research, the present study is an inquiry into participants' experiences of therapeutic enactment (TE), a multimodal group-based trauma intervention. Following their participation in the intervention, participants were interviewed using a video-assisted method known as interpersonal process recall (IPR), with the aim of accessing their experience in a more immediate, less retrospective way than more frequently used interview methods. The interview transcripts were analyzed thematically and are re-presented herein as three distinct accounts of experiencing therapeutic enactment. Insights for both clinical and research development are discussed.
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Brenke, Jara Kerstin [Verfasser], i Daniel [Akademischer Betreuer] Krappmann. "Targeting the TRAF6-Ubc13 interaction for therapeutic intervention / Jara Kerstin Brenke ; Betreuer: Daniel Krappmann". München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2015. http://d-nb.info/1161670742/34.
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Farrelly, Simone. "Therapeutic relationships in community mental health : the impact of the Joint Crisis Plan intervention". Thesis, King's College London (University of London), 2013. https://kclpure.kcl.ac.uk/portal/en/theses/therapeutic-relationships-in-community-mental-health(522a86f6-0fbd-463a-8b4f-cb706078f541).html.
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Policy and professional guidance in England have emphasised the importance of Therapeutic Relationships (TRs) in community mental health care, yet there is no comprehensive model to guide practice or understand the process through which stronger TRs are generated. This thesis investigated TRs in community mental health for individuals with psychotic disorders and was embedded within the CRIMSON trial: a randomised controlled trial of the Joint Crisis Plan (JCP) intervention. JCPs contain service users’ treatment preferences for future care, which are jointly decided with clinicians. Qualitative analyses addressed participants’ views of TRs and JCPs. Quantitative analyses addressed the predictive utility of TRs for outcomes, associations of TRs and the effect of JCPs on service user and clinician-rated TR. Results suggested that significant ambiguity persists regarding what can and should be provided in community mental health, resulting in unhelpful experiences for service users and clinicians. A new model of TRs - Consistent Respect - was developed; it presents TRs as bi¬directional processes, jointly affected by clinicians’ and service users’ experiences of interactions and their roles defined by the wider context; the latter often being a barrier to the development of strong TRs. JCPs significantly improved service users’ appraisals of TRs by providing a structured protocol through which routine role enactments were limited and clinicians could demonstrate Consistent Respect. Positive effects were lost when there were deficiencies in the implementation of JCPs and/or engagement of clinicians. In conclusion, improving TRs through JCPs could facilitate better outcomes and more satisfactory treatment experiences for service users and clinicians. Changes in policy and practice are indicated to facilitate transparent goals and roles for clinicians and respectful interactions with service users.
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Albtoush, Nansy. "Inhibiting the Function of TSG-6 in Inflammatory Models as a Possible Therapeutic Intervention". Cleveland State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=csu1544060182841309.
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Gagnon, Laura. "Efficacy of pilates exercises as therapeutic intervention in treating patients with low back pain". Access full text, 2005. http://etd.utk.edu/2005/GagnonLaura.pdf.
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Thesis (Ph.D.) -- University of Tennessee, Knoxville, 2005.UMI no.: 3177252. "A dissertation presented for the Doctor of Philosophy Degree, The University of Tennessee, Knoxville". "May 2005". Includes bibliographical references (leaves 80-89). Also available via the World Wide Web.
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Yalla, Krishna Chaitanya. "Characterisation of DISC1 ubiquitination and its potential as a therapeutic intervention for psychiatric disorders". Thesis, University of Glasgow, 2014. http://theses.gla.ac.uk/5408/.
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Since its discovery over a decade ago, DISC1 has become one of the most promising candidate genes for Schizophrenia and associated chronic mental disorders. This notion has been supported by a wealth of evidence from genetic and biochemical studies. With multiple interacting partners, DISC1 acts as a scaffold protein, orchestrating vital signalling pathways that underpin neurodevelopment and signalling. While the aetiology of Schizophrenia is poorly understood, loss of DISC1 protein function remains one of the proposed disease mechanisms. Furthermore, its tendency to form aggregates is reminiscent of neurodegenerative illnesses such as Alzheimer’s and Parkinson’s disease. C-terminal truncation of DISC1 (TrDISC1) is known to decrease neurite outgrowth and number in the PC12 cell line, abolish protein interaction with proteins such as Ndel1 and also disrupt vital physiological process such as mitochondrial transport. However, very little is known about the underlying disease mechanism at the molecular level. In order to gain insight in to the role of DISC1 pathway in Schizophrenia and associated mental illnesses, I studied novel post translational modifications of DISC1. The main conclusion of my thesis is that these modifications affect DISC1 turnover and its scaffold function. The work described in this thesis has uncovered 2 novel post translational modifications and identified the E3 ligase involved in regulating DISC1 turn over. My work has also laid the foundation for the design and discovery of both peptide and non-peptide, small molecule inhibitors of the DISC1 and its cognate E3 ligase interaction. These inhibitors can serve as both pharmacological tools and for further investigation of the role of this novel interaction in DISC1 pathway and the vital physiological functions it is involved in. Furthermore, this work also indicates the feasibility of controlled and directed differentiation of patient specific iPS cells in to neurons, which act as a useful tool for disease modelling.
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Hafen, Paul S. "Deep-Tissue Heating as a Therapeutic Intervention to Prevent Skeletal Muscle Atrophy in Humans". BYU ScholarsArchive, 2018. https://scholarsarchive.byu.edu/etd/7464.
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Skeletal muscle is a highly adaptable tissue that comprises approximately 40% of total body weight while accounting for up to 90% of whole-body oxygen consumption and energy expenditure during exercise. The loss of skeletal muscle protein and subsequent decrease in muscle mass (atrophy) that accompanies disuse results primarily from a decrease in intracellular protein synthesis combined with an increase in proteolytic activity. Interestingly, these processes of skeletal muscle atrophy are amplified by changes in mitochondrial capacity, with evidence suggesting that the maintenance of mitochondria during periods of disuse protects skeletal muscle against atrophy. Remarkably, rodents with denervated muscle are protected against muscle atrophy following whole-body heat stress. The mechanism of protection appears to be tied to the observed increases in heat shock protein (HSP) and PGC-1α, which accompany the heat stress. Without any published observations as to whether such heat-induced protection against muscle atrophy would translate to human muscle, the aim of this project was to determine the extent to which deep tissue heating (via pulsed shortwave diathermy) might provide protection against skeletal muscle atrophy.