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Książki na temat „Telomere DNA”

Autor: Grafiati

Data publikacji: 6 września 2023

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1

Brady, Catherine. Elizabeth Blackburn and the story of telomeres: Deciphering the ends of DNA. Cambridge, MA: Massachusetts Institute of Technology, 2007.

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2

Else, Kröner-Fresenius Symposium on Adult Stem Cells in Aging Diseases and Cancer (2013 Eisenach Germany). Adult stem cells in aging, diseases, and cancer. Basel: Karger, 2015.

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3

Advances in stem cell aging. Basel: Karger, 2012.

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4

Else Kröner-Fresenius Symposium on the Molecular Mechanisms of Adult Stem Cell Aging (1st 2009 Günzburg, Germany). Molecular mechanisms of adult stem cell aging. Redaktor Rudolph K. Lenhard. Basel: Karger, 2010.

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5

O, Tollefsbol Trygve, red. Epigenetics protocols. Totowa, N.J: Humana Press, 2004.

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6

Vaziri, Homayoun. Telomeres, DNA damage signaling molecules and cellular aging. Ottawa: National Library of Canada = Bibliothèque nationale du Canada, 1998.

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7

G-quadruplex DNA: Methods and protocols. New York: Humana Press, 2010.

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8

Cano, Maria Isabel Nogueira, Richard McCulloch i Marcelo Santos Da Silva, red. Nuclear Genome Stability: DNA Replication, Telomere Maintenance, and DNA Repair. Frontiers Media SA, 2022. http://dx.doi.org/10.3389/978-2-88974-630-9.

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9

Elizabeth Blackburn and the Story of Telomeres: Deciphering the Ends of DNA. The MIT Press, 2007.

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10

Marti, Amelia, i Guillermo Zalba. Telomeres, Diet and Human Disease: Advances and Therapeutic Opportunities. Taylor & Francis Group, 2017.

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11

Marti, Amelia, i Guillermo Zalba. Telomeres, Diet and Human Disease: Advances and Therapeutic Opportunities. Taylor & Francis Group, 2017.

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12

Marti, Amelia, i Guillermo Zalba. Telomeres, Diet and Human Disease: Advances and Therapeutic Opportunities. Taylor & Francis Group, 2017.

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13

Gray, Doug, Carole Proctor i Tom Kirkwood. Biological aspects of human ageing. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199644957.003.0001.

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At the molecular and cellular levels human ageing is characterized by the accumulation of unrepaired random damage, and an accompanying loss of function. A major source of damage is oxidative stress caused by the generation of reactive oxygen species as a by-product of respiration. DNA and proteins are both susceptible to damage but whereas DNA damage repair systems exist, faulty proteins are generally removed by protein degradation systems. During ageing these systems become less efficient and the subsequent accumulation of damaged protein promotes protein aggregation, a process which is especially problematic in the ageing brain. Other aspects of ageing include genetic and epigenetic changes, mitochondrial dysfunction, telomere shortening, and cellular senescence, all subject to stochasticity. The complexity of the biology of ageing has led to an increase in the use of systems biology approaches whereby the use of mathematical modelling and bioinformatic tools complement the more traditional experimental approaches.

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14

Tollefsbol, Trygve O., i Lucy Andrews. Telomerase Inhibition: Strategies and Protocols. Humana Press, 2011.

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15

Tollefsbol, Trygve O. Epigenetics Protocols. Humana Press, 2004.

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16

Tollefsbol, Trygve O. Epigenetics Protocols. Humana Press, 2016.

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17

Marti, Amelia, i Guillermo Zalba. Telomeres, Diet and Human Disease: Advances and Therapeutic Opportunities. Taylor & Francis Group, 2017.

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18

Telomeres, Diet and Human Disease: Advances and Therapeutic Opportunities. Taylor & Francis Group, 2017.

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19

Burgess, Andrew, i Liz Caldon, red. Proceedings From ACCM19: Cell Cycle, DNA Damage Response and Telomeres. Frontiers Media SA, 2020. http://dx.doi.org/10.3389/978-2-88966-115-2.

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20

Brady, Catherine. Elizabeth Blackburn and the Story of Telomeres: Deciphering the Ends of DNA. MIT Press, 2009.

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21

Brady, Catherine. Elizabeth Blackburn and the Story of Telomeres: Deciphering the Ends of DNA. MIT Press, 2009.

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22

Brady, Catherine. Elizabeth Blackburn and the Story of Telomeres: Deciphering the Ends of DNA. MIT Press, 2009.

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23

Brady, Catherine. Elizabeth Blackburn and the Story of Telomeres: Deciphering the Ends of DNA. MIT Press, 2009.

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24

Silva Gebim, Anna Beatriz, Renato Massaharu Hassunuma, Patrícia Carvalho Garcia i Sandra Heloísa Nunes Messias. 7QXS: o segredo do vampiro, livro-jogo sobre a telomerase. Canal 6 Editora, 2022. http://dx.doi.org/10.52050/9788579175817.

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Várias pesquisas sugerem que uma das causas do processo de envelhecimento seja o encurtamento dos telômeros, que correspondem à extremidade dos cromossomos. O comprimento dos telômeros é regulado por uma enzima denominada telomerase e várias outras proteínas que formam um complexo junto à telomerase. Neste jogo, você pode ser um cientista ou um vampiro que podem descobrir o segredo da imortalidade encontrando as proteínas que fazem parte do complexo telômero-telomerase. Com uma breve explicação e algumas partidas, você irá se familiarizar com os nomes destas biomoléculas e suas estruturas bioquímicas.

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25

Zapico, Sara C. Mechanisms Linking Aging, Diseases and Biological Age Estimation. Taylor & Francis Group, 2017.

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26

Zapico, Sara C. Mechanisms Linking Aging Diseases and Biological Age Estimation. Taylor & Francis Group, 2021.

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27

Mechanisms Linking Aging, Diseases and Biological Age Estimation. Taylor & Francis Group, 2016.

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28

Zapico, Sara C. Mechanisms Linking Aging, Diseases and Biological Age Estimation. Taylor & Francis Group, 2017.

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29

Dodds, Chris, Chandra M. Kumar i Frédérique Servin. Pathophysiological changes of ageing and their relevance to anaesthesia. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198735571.003.0002.

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The molecular basis of ageing is reviewed. This includes the concept of a summation of DNA damage over a lifetime causing genome instability. Epigenetic alterations, telomeric shortening, and the possibility of their modification are discussed. Oxidative and mitochondrial DNA damage and the resulting dysfunction leading to senescence are briefly described. Systemic problems and resultant behavioural adaptation may mask the decline in functional reserve and cause some of the difficulties in identifying its presence in ill elderly patients. Specific organ system changes are then described in some detail. These include the major concerns with the cardiovascular, respiratory, renal, hepatic, neurologic, endocrine, and musculoskeletal systems. The effect of ageing on the special senses of vision and hearing are covered, with emphasis on issues of informed consent.

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30

Stauropoulos, Dimitrios James. An analysis of the interplay between telomeric factors and DNA repair proteins, in the human ALT pathway and cellular response to genomic double strand breaks. 2005.

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