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Panzica, Roberto Calogero <1984>. "Network connectivity, systematic and systemic risk". Doctoral thesis, Università Ca' Foscari Venezia, 2017. http://hdl.handle.net/10579/14091.
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The thesis collects five papers, each of them, except the last one, treats a different topics related to the asset interconnections and asset pricing. The first paper extends the classic factor-based asset pricing model by including network linkages, leading to a network-augmented linear factor models. The contribution of the paper is to show that the network presence affects the exposure on the common factor, the power of the diversification and the expected returns. The second paper generalizes the model used in the first work by allowing the number of network greater than one. This work has two contributions: how to use a linear factor model as a device for estimating a combination of several networks that monitor the links across variables from different viewpoints; and to demonstrate that Granger causality should be combined with quantile-based causality when the focus is on risk propagation. The third paper investigates on the determinants of the idiosyncratic volatility puzzle by allowing the contemporaneous linkages across asset returns. The first contribution is to show that the puzzle found by ang et al 2006, where stocks with high (low)idiosyncratic volatility relative to the FamaFrench1993 model have low (high) average returns, falls if the idiosyncratic volatility is filtered out from the impact coming from the network. The purpose of the fourth paper is to assert the different informative content between quantile based network measures and quantile based loss measures such as ΔCoVaR. Globally Systemically Important Banks and Insurers and several Hedge Fund indices are considered. The contribution of the paper is to show that quantile regression based on network measures capture the indirect effect of risk spillovers that is instead ignored by quantile based loss measures. Finally, the comparison between quantile based network measures and quantile based losses measures highlights the predicting power of the former during the global systemic crisis of 2007/2008. The fifth paper is a not network related topic, it analyses which are the causes to make a contract eligible to be cleared, by using probit analysis.
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Tang, Zhaofeng. "Quantitative risk management under systematic and systemic risks". Diss., University of Iowa, 2019. https://ir.uiowa.edu/etd/7035.
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The contemporary risk management practice emphasizes the interplay of multilevel risks, of which the systematic and systemic risks are considered the main culprits of catastrophic losses. With this in mind, this thesis investigates three important topics in quantitative risk management, in which the systematic and systemic risks play a devastating role.
First of all, we center on the design of reinsurance policies that accommodate the joint interests of the insurer and reinsurer by drawing upon the celebrated notion of Pareto optimality in the context of a distortion-risk-measure-based model. Such a topic is of considerable practical interest in the current post financial crisis era when people have witnessed the significant systemic risk posed by the insurance industry and the vulnerability of insurance companies to systemic events. Specifically, we characterize the set of Pareto-optimal reinsurance policies analytically and introduce the Pareto frontier to visualize the insurer-reinsurer trade-off structure geometrically. Another enormous merit of developing the Pareto frontier is the considerable ease with which Pareto-optimal reinsurance policies can be constructed even in the presence of the insurer's and reinsurer's individual risk constraints. A strikingly simple graphical search of these constrained policies is performed in the special cases of value-at-risk and tail value-at-risk.
Secondly, we propose probabilistic and structural characterizations for insurance indemnities that are universally marketable in the sense that they appeal to both policyholders and insurers irrespective of their risk preferences and risk profiles. We begin with the univariate case where there is a single risk facing the policyholder, then extend our results to the case where multiple possibly dependent risks co-exist according to a mixture structure capturing policyholder's exposure to systematic and systemic risks.
Next, we study the asymptotic behavior of the loss from defaults of a large credit portfolio. We consider a static structural model in which latent variables governing individual defaults follow a mixture structure incorporating idiosyncratic, systematic, and systemic risks. The portfolio effect, namely the decrease in overall risk due to the portfolio size increase, is taken into account. We derive sharp asymptotics for the tail probability of the portfolio loss as the portfolio size becomes large and our main finding is that the occurrence of large losses can be attributed to either the common shock variable or systematic risk factor, whichever has a heavier tail.
Finally, we extend the asymptotic study of loss from defaults of a large credit portfolio under an amalgamated model. Aiming at investigating the dependence among the risk components of each obligor, we propose a static structural model in which each obligor's default indicator, loss given default, and exposure at default are respectively governed by three dependent latent variables with exposure to idiosyncratic, systematic, and systemic risks. The asymptotic distribution as well as the asymptotic value-at-risk and expected shortfall of the portfolio loss are obtained. The results are further refined when a specific mixture structure is employed for latent variables.
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Wyssmann, Kevin L. "Systemic catechesis". Theological Research Exchange Network (TREN), 2002. http://www.tren.com.
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McKinney, Eoin Fergal. "Gene expression profiling in systemic vasculitis and systemic lupus erythematosus". Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609786.
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Jaspers, Ferdinand. "Organizing systemic innovation /". Rotterdam : Erasmus Universiteit, 2009. http://aleph.unisg.ch/hsgscan/hm00232025.pdf.
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Scquizzato, Gianmarco <1989>. "Systemic Risk Measures". Master's Degree Thesis, Università Ca' Foscari Venezia, 2017. http://hdl.handle.net/10579/9570.
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Considering the effects generated by the recent financial crisis, and, given the ease with which a situation of financial distress caused impact beyond and outwith financial system, the concept of systemic risk has gained even more attention in the worldwide community. Despite many studies, there is no recognised single definition of systemic risk and as demonstrated by the existence of numerose metrics in the relative literature, finding effective measures to assess systemic risk is one of the toughest challenges for many individuals and institutions. The aimo of this work is to provide a measure of systemic risk through the use of three econometric methods: principal component analysis, Granger causality test and nonlinear causality test of Diks and Panchenko.
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Qin, Xiaohui. "Papaya systemic acquired resistance". Thesis, University of Hawaii at Manoa, 2003. http://hdl.handle.net/10125/6872.
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Challenge by a pathogen induces systemic acquired resistance (SAR) in plants, a state marked by the elevated expression of pathogenesis related (PR) genes and enhanced resistance to a broad spectrum of pathogens. SAR requires the endogenous accumulation of salicylic acid (SA), and can be induced by exogenous application of SA or related molecules such as benzo(1,2,3) thiadiazole-7-carbothioic acid S-methyl ester (BTH). All tested plants have a SAR response, but some important aspects of SAR differ between species. In this work, four (partial) PR-1 cDNAs were cloned from papaya. One of these, PR-1d, was shown to be induced by BTH. This data, together with previous data showing the induction of SAR related enzymes and enhanced tolerance to a pathogen in response to BTH, demonstrates that papaya has a SAR response and it is induced by BTH. With this knowledge, global profiling of papaya genes induced by BTH was carried out by suppression subtractive hybridization. 25 unique expressed sequence tags (ESTs) induced by BTH were identified, including homologs of numerous genes known to be defense related, and some genes previously unknown to have defense functions. A papaya homolog of NPRl, shown to be required for SAR signal transduction in Arabidopsis, was isolated and found to contain all three structural domains required for activity in Arabidopsis. This data, together with the profile of BTH induced genes, and induction kinetics for some of these genes, shows that papaya SAR is similar in many important aspects to SAR in the model system Arabidopsis. Additionally, tobacco plants over-expressing Arabidopsis NPRI were produced and found to produce elevated (compared to wild-type) levels of PR-la mRNA in response to SA treatment. This demonstrates that even in a heterologous system, over-expression of NPRl may confer an enhanced SAR response.xvi, 116 leaves
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Fanning, Gregory Charles. "Immunogenetics of systemic sclerosis". Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.284535.
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Teh, Lee-Suan. "Neuropsychiatric systemic lupus erythematosus". Thesis, University of Aberdeen, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240703.
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Neuropsychiatric (NP) symptoms are relatively common in patients with SLE. The diverse and dramatic clinical presentations, the unclear pathogenesis, the lack of diagnostic test/s and uncertainties about the optimal management are some problems facing a clinician. When serum anti P antibodies were claimed to be highly correlated to lupus psychosis, this needed confirmation. An ELISA for measuring anti P antibodies was developed and validated. The prevalence of anti P antibodies was determined in different patient groups in a large retrospective study. Although anti P antibodies were highly specific for SLE, there was no correlation between the presence of these antibodies and lupus psychosis or other NP symptoms. Two prospective studies were carried out to eliminate any bias in our retrospective study. In one, none of the patients developed psychosis and these antibodies were not found to be specific for lupus depression or anxiety. In the other, anti P antibodies were measured in Malaysian Chinese SLE patients. No correlation was found between these antibodies and NP-SLE but a high prevalence of these antibodies was demonstrated in this group. Genetic studies showed that there was an increase in HLA-Dr2w16X subtype allele in anti P-positive patients but this did not reach significance. The usefulness of measuring antineuronal antibodies in helping to diagnose NP-SLE was examined but these antibodies were not better indicators of NP-SLE. Although the clinical correlations of anti P antibodies remain controversial, anti P antibodies were found to selectively bind to neuroblastoma cell surfaces in vitro but the nature of the surface antigen was not determined. Finally, sera from patients with lupus psychosis were found to significantly influence the response of neuroblastoma cells to agonist-induced stimulation and if confirmed, would offer an explanation for the reversible changes in cell function associated with psychiatric lupus.
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Simon, Gail. "Writing (as) systemic practice". Thesis, University of Bedfordshire, 2011. http://hdl.handle.net/10547/223012.
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This doctoral portfolio is a collection of papers and pieces of creative writing arising out of therapeutic, supervisory and training conversations and in relation to a wide range of texts. I have wanted to find ways of writing ethically so as to avoid objectifying people and appropriating their words, their life stories. I find ways of writing in which the values and practices of a collaborative, dialogical and reflexive ways of being with people are echoed in the texts. I show how writing and reading are relational practices in that I speak with the participants in the texts as well as with the reader and also with other writers. To do this, I experiment with a variety of written forms and employ literary devices so as to speak from within a range of practice relationships, from within inner dialogue, with real and fictitious characters. Technically and ethically, I try to write in a way which not only captures the sound of talk but which also speaks with the reader who would be reading, and perhaps hearing these accounts of conversation. By sharing a rich level of detail from my polyvocal inner dialogue, I invite the reader into a unique and privileged alongside position as a participant-observer in my work. Inspirational research methodologies include: writing as a method of inquiry, reflexivity, autoethnography, performance ethnography and transgression interpreted by many areas of systemic theory and practice. To support this innovative work, I offer several theoretical and practical papers offering novel developments on systemic practice theory. I situate systemic practice as a research method and demonstrate many family resemblances between systemic inquiry and qualitative inquiry. I offer a reflexive model for systemic practice and practice research which I call Praction Research which regards therapy and research as political acts requiring an activist agenda. Linked to this I politicise ideas of reflexivity by introducing local and global reflexivity and create a political connection with a concept of theorethical choices in theory and ethics in practice research. I propose a new form of ethnography suited to systemic practice, Relational Ethnography in which I draw attention to reflexive relationships between writer and readers, between the voices of inner and outer dialogue in research texts.
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Kaplan, Jennifer Melissa. "Immunomodulation During Systemic Inflammation". University of Cincinnati / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1186158205.
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Shaw, Corrinne. "Learning systemic management practice". Doctoral thesis, University of Cape Town, 2012. http://hdl.handle.net/11427/6883.
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Systems thinking has been proposed as an answer to the question of how management practitioners can best equip themselves to tackle the complexity of management practice. As a body of work intended to transcend disciplinary silos, systems thinking pursues the ideal of generating comprehensive descriptions of real situations. It seeks to do this by embracing a variety of systems approaches and ideas to explain patterns and hypothesise causes of observable empirical events. As systems thinking is a diverse field, there are many knowledge areas and perspectives available to programme designers to facilitate teaching and the learning of systems thinking for management practice. The purpose of this study is to examine students' experience of learning events in the context of an interdisciplinary course designed for the development of management practice through systems thinking. Data was collected from three cohorts of students by observing lectures and class-based group work; and conducting interviews using conversational repertory grid techniques. The interview responses were analysed using grounded theory principles. Based on the findings derived from this qualitative analysis, the process of learning of systems thinking is outlined as a practice involving the selection and interpretation of events which evolve from the starting out phase, where students become interested in learning, and then outlines progress through the phases of assimilation and, changes in knowledge, culminating in more complex learning phases described as integration and adaptation. The synthesis of these phenomena as a theory provided an answer to the primary research objective of investigating how students experience learning events designed to develop systemic management practice. Critical realism, following Bhaskar's philosophy, is used to frame explanations to extend the grounded theory analysis, seeking to account for generative mechanisms that enable and constrain student experience with respect to systems thinking development. As a secondary contribution, this informed the identification of possible mechanisms and emergent properties at the level of the course through an analytical separation of the academic and work environments. These included the discourse of the context of application, academic discourse and professional identity. In combination, these findings make a contribution to understanding the learning of systemic management practice. In addition, applications for this research are suggested for educators, managers and organisations. These applications include: 1) a framework to help educators design meaningful experiences for learners; 2) a basis for understanding what constitutes systemic management practice and explaining differential development; 3) establishment of a basis for understanding what is needed for organisations to support the development of systemic management practice.
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Lövgren, Tanja. "Endogenous type I interferon inducers in systemic autoimmune diseases /". Uppsala : Acta Universitatis Upsaliensis, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7181.
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Kilou, A. "African systemic norms and states' deviation : The O.A.U. response; a systemic and comparative interpretation". Thesis, Lancaster University, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.379741.
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Hyder, Joseph Anthony. "Systemic atherosclerosis and bone density". Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2006. http://wwwlib.umi.com/cr/ucsd/fullcit?p3211934.
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Thesis (Ph. D.)--University of California, San Diego and San Diego State University, 2006.Title from first page of PDF file (viewed June 21, 2006). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 121-139).
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Winkel, Edwin Geralt. "Systemic antibiotic therapy in periodontics". [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2000. http://dare.uva.nl/document/57310.
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Bernatsky, Sasha. "Malignancy in systemic lupus erythematosus". Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=32761.
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Objectives. (1) To estimate cancer incidence in systemic lupus erythematosus (SLE) as compared to the general population. (2) To estimate the sensitivity and specificity of methods of cancer ascertainment. (3) To determine the prevalence of malignancy risk factors in SLE. Methods. (1) We determined the incidence of malignancy in the Montreal General Hospital (MGH) lupus cohort, through linkage with the Quebec tumor registry. Standardized incidence ratios (SIRS) were generated, using Quebec population rates. In addition, a meta-analysis was performed by pooling data from eight cohort studies of malignancy in SLE. (2) We administered a postal survey to cohort members to determine risk factors for cancer and self-report of cancer occurrence. For dead or lost-to-follow-up patients, data was abstracted from charts. We calculated the sensitivity and specificity of self-report and chart review for cancer ascertainment, compared to registry linkage results. (3) Using the data collected on self-report and chart review, we compared risk factor prevalence within the MGH cohort to that of the Quebec population. Results. (1) Observed cancers in our cohort were greater than what would be expected; for all cancers, the SIR was 1.8 (95% Confidence Interval 1.2--2.6). The meta-analysis SIR (for all malignancies) was 1.67 (1.42--1.94). Postal survey and chart review methods demonstrated high specificity. Sensitivity was imperfect, but did not greatly effect estimation of the SIR estimate. (2) Our lupus cohort had a distinct profile of risk factors for malignancy compared to the general population; differences included more prevalent nulliparity, obesity, and use of hormone replacement therapy. Conclusions. The risk of malignancy in SLE patients is increased. Risk factor profiles could influence the incidence of certain malignancies in SLE.
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Fischer, Manfred M. "A Systemic Approach to Innovation". WU Vienna University of Economics and Business, 2001. http://epub.wu.ac.at/4238/1/WGI_DP_7501.pdf.
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The objective of this paper is to increase our ability to understand the systems of innovation
approach as a flexible and useful conceptual framework for innovation analysis. It presents an
effort to develop some missing links and to decrease the conceptual noise often present in the
discussions on national innovation systems. The paper specifies elements and relations that seem to
be essential to the conceptual core of the framework and argues that there is no a priori reason to
emphasise the national over the subnational [regional] scale as an appropriate mode for analysis,
irrespective of time and place. Localised input-output relations between the actors of the system,
knowledge spillovers and their untraded interdependencies lie at the centre of the arguments.
The paper is organised as follows. It introduces the reader, first, to some basic elements and
concepts that are central to understanding the approach. The characteristics of the innovation
process are examined: its nature, sources and some of the factors shaping its development.
Particular emphasis is laid on the role of knowledge creation and dissemination based on the
fundamental distinction between codified and tacit forms. These concepts recur throughout the
paper and particularly in discussions on the nature and specifications of the systems approach. The
paper concludes by summarising some of the major findings of the discussion and pointing to some
directions for future research activities. (author's abstract)Series: Discussion Papers of the Institute for Economic Geography and GIScience
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Fonseca, Gutierrez Maria del Carmen. "Genetic polymorphism in systemic sclerosis". Thesis, University College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.409294.
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ANTONACCIO, CARLA FRANCISCA BOTTINO. "FAMILY BUSINESSES: A SYSTEMIC COMPREHENTION". PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2007. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=9868@1.
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PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIROAs empresas familiares são a forma predominante de organização empresarial em todo o mundo e seu campo de estudos teórico- práticos surgiu, sobretudo, na década de 1980, em torno de questões relacionadas com a sucessão e a profissionalização. Partindo de uma abordagem sistêmica, a empresa familiar pode ser considerada como um sistema formado por três subsistemas - a família, a administração e a propriedade da empresa. O objetivo deste trabalho é investigar o funcionamento das empresas familiares, tendo em vista a influência recíproca destes subsistemas e seus impactos sobre as fronteiras que os delimitam e os distinguem. Realizou-se uma revisão bibliográfica sobre as abordagens sistêmicas da família e das empresas familiares. Um estudo exploratório foi realizado, junto a três grupos de sujeitos envolvidos com tais empresas: profissionais que prestam serviços às empresas, funcionários que não fazem parte da família, e herdeiros que trabalham, ou não, nas empresas de suas respectivas famílias. A análise do discurso dos sujeitos e a articulação da percepção dos diferentes grupos, sobre este tipo de empresa, possibilitaram uma visão mais abrangente e menos fragmentada das questões que envolvem as empresas familiares. Dessa forma este estudo contribui para um melhor entendimento dessas organizações e para a própria resolução das questões que afetam a saúde e a continuidade das empresas familiares.
Family businesses are the most common type of business worldwide. As a field of research, family businesses emerged during the 1980s around the issues concerning formalization and succession. From a systemic approach, family businesses can be defined as a system comprising three sub- systems - the family, the administration and the property. This study investigates the operation of family businesses considering that the sub-systems comprising such businesses exert reciprocal influence and impact upon the borders that define and distinguish each sub-system. A bibliographic review was conduced of studies applying the systemic approach to families and to family businesses. This review was then combined to an exploratory research of three groups of people directly involved with family businesses: professionals that provide services to family businesses, employees that do not belong to the families, and heirs that may or may not work for the businesses owned by their families. The discourse of these individuals was analyzed, and their different perceptions of family businesses were combined to provide a more comprehensive, less fragmented view of this type of business and its related issues. This study contributes to the understanding of family businesses and facilitating the resolution of the main issues that affect both the businesses and the families.
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Dang, Hieu. "Essays in Financial Systemic Risk". The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1596018496809798.
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Silva, Walmir Geraldo da. "Essays on financial systemic risk". reponame:Repositório Institucional da UnB, 2018. http://repositorio.unb.br/handle/10482/32512.
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES).
This dissertation presented to obtain the Ph.D. degree in Business Administration is composed of two articles. The first one presents an analysis of the literature on systemic financial risk. To that end, we analyze and classify 266 articles that were published no later than September 2016 in the databases Scopus and Web of Knowledge; these articles were identified using the keywords “systemic risk”, “financial stability”,“financial”, “measure”, “indicator”, and “index”. They were evaluated based on 10 categories, namely, type of study, type of approach, object of study, method, spatial scope, temporal scope, context, focus, type of data used, and results. The analysis and classification of this literature made it possible to identify the remaining gaps in the literature on systemic risk; this contributes to a future research agenda on the topic. Moreover, the most influential articles in this field of research and the articles that compose the main stream research on systemic financial risk were identified. In the second article, we model an indicator that aims to identify systemic risk in the financial markets. Using 93 assets from different classes and from both developed and emerging countries, we apply principal components analysis (PCA) to calculate an initial indicator that is then submitted to Markov switching (MS) technique. This procedure advances the use of PCA in systemic risk modelling by preventing the need for arbitrary definitions of normal and stressed regimes. Additionally, applying MS to the indicator extracted by PCA from the correlation matrix of a relevant number of assets of various classes supports the argument that the indicator is indeed systemic. The results show that the probabilities that the indicator is under stress, according to the MS model, can be used as a signal of systemic risk. We also verified that the average risk of assets, calculated by the average value-at-risk (VaR), is affected when the series of these assets are separated in the systemic risk and normal regimes. In addition, we measure the performance of the indicator compared to other metrics built with only an asset class, especially stock indices. The results show that our model adequately depicts periods of high systemic risk, being relatively thorough.
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Mosmann, Gabriela. "Axiomatic systemic risk measures forecasting". reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2018. http://hdl.handle.net/10183/178875.
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Neste trabalho, aprofundamos o estudo sobre risco sistêmico via funções de agregação. Consideramos três carteiras diferentes como proxy para um sistema econômico, estas carteiras são consistidas por duas funções de agregação, baseadas em todos as ações do E.U.A, e um índice de mercado. As medidas de risco aplicadas são Value at Risk (VaR), Expected Shortfall (ES) and Expectile Value at Risk (EVaR), elas são previstas através do modelo GARCH clássico unido com nove funções de distribuição de probabilidade diferentes e mais por um método não paramétrico. As previsões são avaliadas por funções de perda e backtests de violação. Os resultados indicam que nossa abordagem pode gerar uma função de agregação adequada para processar o risco de um sistema previamente selecionado.In this work, we deepen the study of systemic risk measurement via aggregation functions. We consider three different portfolios as a proxy for an economic system, these portfolios are consisted in two aggregation functions, based on all U.S. stocks and a market index. The risk measures applied are Value at Risk (VaR), Expected Shortfall (ES) and Expectile Value at Risk (EVaR), they are forecasted via the classical GARCH model along with nine distribution probability functions and also by a nonparametric approach. The forecasts are evaluated by loss functions and violation backtests. Results indicate that our approach can generate an adequate aggregation function to process the risk of a system previously selected.
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Clarke, Alexander James. "Autophagy in Systemic Lupus Erythematosus". Thesis, King's College London (University of London), 2015. http://kclpure.kcl.ac.uk/portal/en/theses/autophagy-in-systemic-lupus-erythematosus(1e5a4a5e-99f7-456e-bcb4-634a4e3fd986).html.
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Autophagy has emerged as a critical homeostatic mechanism in lymphocytes, influencing proliferation and differentiation. I sought to explore the role of autophagy in the pathogenesis of human and murine lupus, a disease in which B cells are critical effectors of pathology. Autophagy was assessed using multiple techniques in NZB/W and control mice, and in patients with SLE compared to healthy controls. I evaluated the phenotype of the B cell compartment in Vav-Atg7-/- mice in vivo, and examined human and murine plasmablast formation following inhibition of autophagy. I found activation of autophagy in early developmental stages of B cell development in a lupus mouse model even before disease-onset, and which progressively increased with age. In human disease, again autophagy was activated compared with healthy controls, principally in naïve B cells. B cells isolated from Vav-Atg7-/- mice failed to effectively differentiate into plasma cells following stimulation in vitro. Similarly, human B cells stimulated in the presence of autophagy inhibition did not differentiate into plasmablasts. My data suggest activation of autophagy is a mechanism for survival of autoreactive B cells, and also demonstrate that it is required for plasmablast differentiation, processes that induce significant cellular stress. The implication of autophagy in two major pathogenic pathways in SLE suggests the potential to use inhibition of autophagy as a novel treatment target.
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Hicks, Kevin Myron. "Systemic renewal a congregational perspective /". Theological Research Exchange Network (TREN), 2000. http://www.tren.com.
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Whitelaw, Casey. "Systemic features for text classification". Thesis, The University of Sydney, 2005. https://hdl.handle.net/2123/28097.
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This thesis applies Systemic Functional Linguistics (SFL) to the automatic analysis
of text. SFL is a theory that describes language use primarily in terms of meaning.
While widely used for text generation, the difficulty of complete automatic SFL
analysis has kept it out of the text analysis mainstream. This thesis presents a new
partial analytical model for SFL, designed to allow domain—specific systemic models
to be used in shallow processing for text classification.
In this model, language use in a document is identified through the use of a
systemic extractor, for which algorithms are presented and shown to be fast7 eflicient
and scalable. Documents are then represented as a set of systemic features, which
leverage SFL theory to provide more meaningful representations. These systemic
features are used to perform supervised text classification using statistical machine
learning algorithms.
The properties of systemic features are explored in a series of case studies upon
different types of text classification tasks, using different parts of SFL. Systemic
features prove useful in identifying interpersonally close and distant documents; in
improving the classification of financial scams; and in the identification of positive
and negative opinion.
As presented in this thesis, language use described by SFL can be modelled and
extracted efficiently and used effectively in real—world text classification tasks.
27
Tawadros, Fady, i Kanishka Chakraborty. "Systemic Mastocytosis with associated CMML". Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/asrf/2018/schedule/75.
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Systemic mastocytosis refers to a heterogeneous group of clinical disorders characterized by excessive mast cell accumulation in one or multiple organs. Mastocytosis is now considered as a separate disease category in the 2016 WHO classification of myeloid neoplasm and acute leukemia. It is no longer considered as a subgroup of meyloproliferate neoplasms.
The clinical presentation of mastocytosis is heterogeneous ranging from skin-limited disease (cutaneous mastocytosis) to a more aggressive form with extra cutaneous presentation (systemic mastocytosis) with or without skin involvement. We are presenting a case of systemic mastocytosis that aroused in a patient who carried diagnosis of CMML for almost 2 years. The worsening B symptoms along with worsening splenomegaly were the driving factor for further investigations including Bone Marrow biopsy which revealed the diagnosis.
A 74 year old Caucasian male with past oncology history of Chronic myelomoncytic leukemia diagnosed after persistant monocytosis on complete blood count . Patient presented with gradual onset of low grade fever , weight loss and night sweating , CT abdomen showed hepatosplenomegaly. core biopsy of the liver showed portal and lobular infiltrate consistent with involvement by mastocytes and extra medullary hematopoiesis. The infiltrate was positive for CD117, CD33, CD68, myeloperoxidase and CD163.
Patient had bone marrow biopsy which showed increased CD117 positive cells consistent with involvement by systemic mastocytosis. The core biopsy showed multifocal nodules of spindle cells with fibrosis which was morphologically consistent with abnormal mast cells. Immunohistochemistry for CD117 was strongly positive in the spindle cell nodules and scattered polygonal cell nodules. KIT D816V mutation was detected. Patient met criteria for diagnosis of systemic mastocytosis with presence of previous diagnosis of CMML and classified as Systemic mastocytosis with an associated hematologic neoplasm (SM-AHN). Due to patient multiple comorbiditeis , he was not a candidate for Allo HCT. In an attempt to control his disease , patient was started on dose reduced Dacogen, but his functional status continued to delined and eventually dacogen was discontinued and patient was placed on best supportive car
Conclusion
Systemic mastocytosis is a rare entity with heterogeneous clinical presentation, highly variable disease course and consequently survival rates.Though recent advances in understanding genetic and molecular basis of disease, bone marrow transplantation remains the only treatment with possible curative potential in patients with advanced form of mastocytosis though carrying substantial mortality risk .Further understanding of Kit mutation might be able to offer a highly effective medication with durable response in a fashion similar to the success story of gleevac with CML treatment .
28
Tasca, Paolo <1976>. "Diversification, leverage and systemic risk". Doctoral thesis, Università Ca' Foscari Venezia, 2012. http://hdl.handle.net/10579/1188.
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The Thesis investigates from a theoretical perspective the relationship between leverage, diversification and systemic risk. Moving from the folk wisdom that asset diversification enhances financial stability by dispersing credit risks, we contribute to the debate shedding light on a critical facet of this strategy. First a representative leveraged investor is considered. Under the standard framework of asset pricing theory in a frictionless, arbitrage-free and complete market, we show
that maximum diversification may increase the default risk. Then, we consider a financial system of interconnected banks whose assets include also securities outside the financial network. We show that diversification in external assets displays a knife-edge effect: beyond a certain range, it may induce financial instability. Finally, we found that in presence of procyclical capital requirements that create a positive feedback loop between leverage and asset prices, the knife-edge property is
amplified.La Tesi esamina da un punto di vista teorico la relazione tra leva finanziaria, diversificazione e rischio sistemico. Partendo dalla convinzione popolare che la diversificazione innalza la stabilità finanziaria attraverso la diluzione dei rischi, collaboriamo al dibattito facendo luce su un aspetto critico di questa strategia. Consideriamo dapprima un investitore in leva. Sotto le condizioni standard della teoria moderna della finanza, dimostriamo che la massima diversificazione può aumentare il rischio di fallimento. Successivamente, consideriamo un sistema finanziario composto da banche con mutua esposizione finanziaria tra di loro e che investono in attività esterne al sistema. Dimostriamo che la diversificazione in attività esterne oltre un certo livello può diminuire la stabilità finanziaria: effetto 'filo di rasoio'. Alla fine troviamo che in presenza di regolamenti di capitale che creano un ciclo tra leva e prezzi, la diversificazione amplifica l'effetto 'filo di rasoio'.
29
Pasqualini, Andrea <1990>. "Approaching Systemic Risk with Entropy". Master's Degree Thesis, Università Ca' Foscari Venezia, 2014. http://hdl.handle.net/10579/5208.
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This Thesis focuses on the Marginal Expected Shortfall (MES) and its application in Finance as early-warning reference. I will specify a logit model that allows to link MES to the conditional probability of financial crisis.
The analysis includes a multinomial bayesian density estimation approach, and considers different crisis indicators as dependent variables.
30
Salhi, Khadidja <1991>. "MONETARY POLICY AND SYSTEMIC RISK". Master's Degree Thesis, Università Ca' Foscari Venezia, 2018. http://hdl.handle.net/10579/13439.
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SWIATCZAK, BARTLOMIEJ JAROSLAW. "SYSTEMIC FEATURES OF IMMUNE RECOGNITION". Doctoral thesis, Università degli Studi di Milano, 2012. http://hdl.handle.net/2434/173418.
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The gut is home to a great number of microbes. The immune system, to protect the body, must discriminate between the pathogenic and non-pathogenic microbes and respond to them in different ways. How the mucosal immune system manages to make this distinction is poorly understood. Here, we explore whether the decision to respond in a certain way to a microorganism is made by single types of cells and molecules or by the collective activity of various kinds of cells and molecules in a given anatomical compartment. We show here that the distinction between pathogenic and non-pathogenic microbes is made by an integrated system rather than by single types of cells or single types of receptors.
Since immune recognition is constituted by a complex network of molecular and cellular level interactions, complete understanding of this process requires knowledge of these interactions. However, is it possible to explain immune recognition in molecular and cellular terms if this process is multiple realizable? Indeed, given the number and dynamics of elements involved in the recognition, it is hardly possible that their exact configuration could ever be reproduced even in the same individual.
We argue that it is practically impossible to reduce immune recognition to its actual molecular and cellular realization. (This would require making reference to an infinitely long disjunction of lower level processes and each disjunct would be endlessly complex). Instead, the recognition is reducible to the approximation of molecular and cellular level processes. We suggest that the same strategy that was used by us to explain immune recognition in terms of lower level approximations is commonly applied by molecular biologists and systems biologists to explain complex biological processes.
32
Benoit, Sylvain. "Three Essays on Systemic Risk". Electronic Thesis or Diss., Orléans, 2014. http://www.theses.fr/2014ORLE0508.
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Le risque systémique a joué un rôle clé dans la propagation de la dernière crise financière mondiale.Un grand nombre de mesures de ce risque ont été développées pour évaluer la contribution d’une institutionfinancière au risque de l’ensemble du système. Toutefois, de nombreuses questions concernantles capacités de ces mesures à identifier les institutions financières d’importance systémique (SIFIs) ontété soulevées puisque le risque systémique possède de multiples facettes et certaines d’entre elles sontdifficiles identifier, telles que les similitudes entre institutions financières.L’objectif général de cette thèse en finance est donc (i) de proposer une solution empirique pour identifierles SIFIs au niveau nationale, (ii) de comparer théoriquement et empiriquement différentes mesures durisque systémique et (iii) de mesurer les changements d’expositions au risque des banques.Tout d’abord, le chapitre 1 propose un ajustement de trois mesures de risque systémique basées sur desdonnées de marchés et conçues dans un cadre international, afin d’identifier les SIFIs au niveau national.Ensuite, le chapitre 2 introduit un modèle commun dans lequel plusieurs mesures du risque systémiquesont exprimées et comparées. Il y est théoriquement établi que ces mesures de risque systémique peuventêtre exprimées en fonction de mesures traditionnelles de risque. L’application empirique confirme cesrésultats et montre que ces mesures ne sont pas capables de saisir la nature multidimensionnelle durisque systémique. Enfin, le chapitre 3 présente la méthodologie appelée Factor Implied Risk Exposures(FIRE) permettant de décomposer une variation de la mesure de risque d’une banque en deux éléments,le premier représentant la volatilité de marché et le second correspondant à l’exposition au risque de labanque. Ce chapitre illustre empiriquement que les changements d’expositions au risque sont corréléspositivement entre les banques, ce qui est cohérent avec le fait que les banques présentent des similitudesdans leurs prises de positions sur le marchéSystemic risk has played a key role in the propagation of the last global financial crisis. A large number ofsystemic risk measures have been developed to quantify the contribution of a financial institution to thesystem-wide risk. However, numerous questions about their abilities to identify Systemically ImportantFinancial Institutions (SIFIs) have been raised since systemic risk has multiple facets, and some of themare difficult to gauge, such as the commonalities across financial institutions.The main goal of this dissertation in finance is thus (i) to propose an empirical solution to identifydomestic SIFIs, (ii) to compare theoretically and empirically different systemic risk measures, and (iii)to measure changes in banks’ risk exposures.First, chapter 1 offers an adjustment of three market-based systemic risk measures, designed in a globalframework, to identify domestic SIFIs. Second, chapter 2 introduces a common framework in whichseveral systemic risk measures are expressed and compared. It is theoretically shown that those systemicrisk measures can be expressed as function of traditional risk measures. The empirical application confirmsthese findings and shows that these measures fall short in capturing the multifaceted nature of systemicrisk. Third, chapter 3 proposes the Factor Implied Risk Exposures (FIRE) methodology which breaksdown a change in risk disclosure into a market volatility component and a bank-specific risk exposurecomponent. This chapter empirically illustrates that changes in risk exposures are positively correlatedacross banks, which is consistent with banks exhibiting commonality in trading
33
Benoit, Sylvain. "Three Essays on Systemic Risk". Thesis, Orléans, 2014. http://www.theses.fr/2014ORLE0508/document.
Pełny tekst źródłaStreszczenie:
Le risque systémique a joué un rôle clé dans la propagation de la dernière crise financière mondiale.Un grand nombre de mesures de ce risque ont été développées pour évaluer la contribution d’une institutionfinancière au risque de l’ensemble du système. Toutefois, de nombreuses questions concernantles capacités de ces mesures à identifier les institutions financières d’importance systémique (SIFIs) ontété soulevées puisque le risque systémique possède de multiples facettes et certaines d’entre elles sontdifficiles identifier, telles que les similitudes entre institutions financières.L’objectif général de cette thèse en finance est donc (i) de proposer une solution empirique pour identifierles SIFIs au niveau nationale, (ii) de comparer théoriquement et empiriquement différentes mesures durisque systémique et (iii) de mesurer les changements d’expositions au risque des banques.Tout d’abord, le chapitre 1 propose un ajustement de trois mesures de risque systémique basées sur desdonnées de marchés et conçues dans un cadre international, afin d’identifier les SIFIs au niveau national.Ensuite, le chapitre 2 introduit un modèle commun dans lequel plusieurs mesures du risque systémiquesont exprimées et comparées. Il y est théoriquement établi que ces mesures de risque systémique peuventêtre exprimées en fonction de mesures traditionnelles de risque. L’application empirique confirme cesrésultats et montre que ces mesures ne sont pas capables de saisir la nature multidimensionnelle durisque systémique. Enfin, le chapitre 3 présente la méthodologie appelée Factor Implied Risk Exposures(FIRE) permettant de décomposer une variation de la mesure de risque d’une banque en deux éléments,le premier représentant la volatilité de marché et le second correspondant à l’exposition au risque de labanque. Ce chapitre illustre empiriquement que les changements d’expositions au risque sont corréléspositivement entre les banques, ce qui est cohérent avec le fait que les banques présentent des similitudesdans leurs prises de positions sur le marchéSystemic risk has played a key role in the propagation of the last global financial crisis. A large number ofsystemic risk measures have been developed to quantify the contribution of a financial institution to thesystem-wide risk. However, numerous questions about their abilities to identify Systemically ImportantFinancial Institutions (SIFIs) have been raised since systemic risk has multiple facets, and some of themare difficult to gauge, such as the commonalities across financial institutions.The main goal of this dissertation in finance is thus (i) to propose an empirical solution to identifydomestic SIFIs, (ii) to compare theoretically and empirically different systemic risk measures, and (iii)to measure changes in banks’ risk exposures.First, chapter 1 offers an adjustment of three market-based systemic risk measures, designed in a globalframework, to identify domestic SIFIs. Second, chapter 2 introduces a common framework in whichseveral systemic risk measures are expressed and compared. It is theoretically shown that those systemicrisk measures can be expressed as function of traditional risk measures. The empirical application confirmsthese findings and shows that these measures fall short in capturing the multifaceted nature of systemicrisk. Third, chapter 3 proposes the Factor Implied Risk Exposures (FIRE) methodology which breaksdown a change in risk disclosure into a market volatility component and a bank-specific risk exposurecomponent. This chapter empirically illustrates that changes in risk exposures are positively correlatedacross banks, which is consistent with banks exhibiting commonality in trading
34
Fan, Hiu-yi Rosie. "Cost of systemic lupus erythematosus in Hong Kong /". View the Table of Contents & Abstract, 2005. http://sunzi.lib.hku.hk/hkuto/record/B32020636.
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Wong, Kee-lam, i 黃基林. "Systemic lupus erythematosus in Hong Kong". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1990. http://hub.hku.hk/bib/B31981410.
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Ylitalo, A. (Antti). "Cardiovascular autonomic regulation in systemic hypertension". Doctoral thesis, Oulun yliopisto, 1999. http://urn.fi/urn:isbn:9514252128.
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Abstract
Neurogenic factors are known to be important in the development of hypertension. Our current knowledge of the role of autonomic nervous system in chronic hypertension is, however, limited. The purpose of the present study was to evaluate the possible abnormalities in heart rate variability (HRV) and baroreflex sensitivity (BRS) in patients with long standing systemic hypertension compared to subjects without evidence of cardiovascular disease. A particular aim was also to examine whether genetic variation in the renin-angiotensin-aldosterone system (RAS) genes have an influence on cardiovascular autonomic regulation.
Case-control studies were carried out on a total of 280 normotensive and 214 hypertensive subjects drawn from a random middle-aged population originally recruited for an epidemiologic study of cardiovascular risk factors. The possible association of BRS with the genetic polymorphisms of renin-angiotensin-aldosterone system genes was studied in a cross-sectional study of 315 healthy controls. Genetic associations were also tested in a younger, independent population sample of 66 subjects. The effects of intensified antihypertensive treatment on autonomic cardiovascular control were evaluated in 33 hypertensive patients with poor blood pressure control.
Wide interindividual variation in both HRV and BRS was observed in normotensive as well as hypertensive subjects. Overall HRV and autonomic responses to a change in body posture were blunted in long-standing hypertension. Decreased HRV was mainly related to elevated blood pressure and obesity.
For the first time in a population-based study, it was confirmed that BRS is impaired in patients with long-standing hypertension despite adequate antihypertensive treatment. In contrast to HRV, BRS was reduced in hypertensive subjects also after adjustment for blood pressure and obesity. BRS also varied widely both between healthy and hypertensive individuals. The wide interindividual variation in the markers of autonomic cardiovascular regulation was not, however, completely explained by demographic variables, cardiovascular risk factors or lifestyle, suggesting a genetic component contributing to HRV and BRS.
The polymorphism in the aldosterone synthase (CYP11B2) gene was found to strongly associate with BRS in two independent random populations of apparently healthy subjects. The association was even stronger in the younger population. On the basis of the observations made in the older population, it seems possible that women are protected against the effect of age and blood pressure on BRS and tend to maintain the genomic influence longer.
Intensified antihypertensive combination therapy improved blood pressure control and caused regression of left ventricular hypertrophy, and resulted in significant improvements of HRV and BRS.
The present study shows that HRV and BRS are altered in long-standing systemic hypertension. Together with age, blood pressure and obesity, genetic factors seem to be important determinants of BRS. However, abnormal autonomic cardiovascular regulation does not seem to be an irreversible phenomenon, but can be partly restored by modern combination antihypertensive therapy.
37
Mokbel, Rita. "Systemic risk in financial economic institutions". Thesis, Besançon, 2016. http://www.theses.fr/2016BESA2080.
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Les crises financières et les problèmes se formaient mais les indicateurs ne sont pas précis pour permettre une intervention réglementaire. La thèse propose un modèle dynamique pour le système bancaire avec une banque centrale afin de calculer un indicateur de faillite en fonction de la probabilité qu'une banque soit en faillite et les pertes rencontrées dans le réseau financier, une méthodologie qui peut améliorer la mesure, le suivi et la gestion du risque systémique.La thèse propose également des mécanismes de compensation : 1- avec un modèle considérant l'ancienneté du passif et avec un type d'actif liquide dont la vente excessive conduit à un impact sur le marché, 2 - avec un modèle considérant les participations croisées entres les banques dont les engagements interbancaires sont de différentes séniorités et avec un type d'actif liquide dont la vente excessive conduit à un impact sur le marchéFinancial crisis pose important theoretical problems on creating reliable indicator of stability of financial systems on which basis the regulators could intervene. The thesis proposes a dynamic model of banking system were the central bank can calculate an indicator of potential defaults taking into consideration the probability for a bank to default and the losses encountered in the financial network, a methodology that can improve the measurement, monitoring, and the management of the systemic risk. The thesis also suggests a clearing mechanisms : 1- in a model with seniority of liabilities and one type of liquid asset whose fire sale has a market impact, 2 - in a model with crossholdings among the banks whose interbank liabilities may be senior and junior and with one liquid asset whose firing sale has a market impact
38
Roukny, Tarik. "Financial Networks, Complexity and Systemic Risk". Doctoral thesis, Universite Libre de Bruxelles, 2016. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/223913.
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The recent financial crisis has brought to the fore the need to better understand systemic risk, that is, the risk of collapse of a large part of the financial system and its potential effects on the real economy. In this thesis, we argue that a proper assessment of systemic risk must include an analysis of the network of interdependencies that exists between the different financial institutions. In fact, today's level of financial interconnectedness between and among markets has proven to have ambiguous effects. On the one hand, a highly connected system allows to diversify risk at the micro level. On the other hand, too much interdependencies provide various paths for contagion to take place and propagate at the macro level. In what follows, we analyze financial markets as networks of interactions and dependencies between financial agents. Through this lens, we investigate three major aspects: (i) how the structure of financial networks can amplify or mitigate the propagation of financial distress, (ii) what are the implications for macro-prudential regulation and (iii) which patterns of interactions characterize real financial networks.We start out by delivering a stability analysis of a network model of interbank contagion that accounts for panics and bank runs. We identify the effects of market architecture, banks' capital ratios, market liquidity and shocks. Our results show that no single network architecture is always superior to others. In particular, highly concentrated networks can both be the most robust and the most fragile depending on other market characteristics, mainly, liquidity.We then move on to tackle issues related to the building of regulatory frameworks that adequately account for the effects of financial interdependencies. We propose a new methodology to compute individual and systemic probabilities of default and show that certain network characteristics give rise to uncertainty. More precisely, we find that network cycles are responsible for the emergence of multiple equilibria even in the presence of complete knowledge. In turn, multiple equilibria give rise to uncertainty for the regulator in the determination of default probabilities. We also quantify the effects of network structures, leverage, volatility and correlations.Having introduced a way to overcome multiplicity, we deliver a method that quantifies the price of complexity in financial markets based on the above mentioned model. This method consists of determining the scope of possible levels of systemic risk that can be obtained when some parameters are subject to small deviations from their true value. The results show a price to the interconnected nature of credit markets even when the equilibrium is unique: small errors can lead to large mistakes in measuring the likelihood of systemic default. Extending the model to account for derivative contracts, we show that error effects increase dramatically as more types of contracts are present in the system. While there is an intuition for such phenomenon, our framework formalizes the idea and quantifies its determinants.In the last part of this thesis, we contribute to the quantitative analysis of real financial networks. We start with a temporal network analysis of one of the major national interbank markets, that is, the German interbank market. We report on the structural evolution of two of the most important over-the-counter markets for liquidity: the interbank market for credit and for derivatives. We find that the majority of interactions is concentrated onto a set of few market participants. There also exists an important correlation between the borrowing and lending activities for each bank in terms of numbers of counterparties. In contrast with other works, we find little impact of the 2008 crisis on the structure of the credit market. The derivative market however exhibits a peak of concentration in the run up to the crisis. Globally, both markets exhibit large levels of stability for most of the network metrics and high correlation amongst them.Finally, we analyze how banks interact with the real economy by investigating the network of loans from banks to industries in Japan. We find evidence of a particular structure of interactions resulting from the coexistence of specific strategies both on the lending side and the borrowing side: generalist agents and specialist agents. Generalist banks have a diversified portfolio (i.e. they provide liquidity to almost all industries) while specialist banks focus their activity on a narrow set of industries. Similarly, generalists industries obtain credit from all banks while specialist industries have a restricted number of creditors. Moreover, the arrangement of interactions is such that specialists tend to only interact with generalists from the other side. Our model allows to structurally characterize highly persistent, and economically meaningful, sets of generalists and specialists. We further provide an analysis of the factors that predict whether a given bank or industry is a generalist. We show that size is an important determinant, both for banks and industries, but we also highlight additional relevant factors. Finally, we find that generalist banks tend to be less vulnerable. Hence, how banks position themselves in the network has important implications for their risk profile. Overall the results presented in this thesis highlight the complex role played by financial interlinkages. Therefore, they demonstrate the need to embed the network dimension in the regulatory framework to properly assess the stability profile of financial systems. Such findings are relevant for both theoretical modeling and empirical investigations. We believe that they also shed light on crucial aspects of systemic risk relevant for policy making and regulation of today's complex financial systems.Doctorat en Sciences de l'ingénieur et technologie
info:eu-repo/semantics/nonPublished
39
Peschken, Christine A. "Systemic lupus erythematosus in Manitoba Aboriginals". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0019/MQ55086.pdf.
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Svenungsson, Elisabet. "Cardiovascular disease in systemic lupus erythematosus /". Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-501-8.
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Leeuw, Karina de. "Premature atherosclerosis in systemic autoimmune diseases". [S.l. : [Groningen : s.n.] ; University Library Groningen] [Host], 2008. http://irs.ub.rug.nl/ppn/.
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Johnson, Scott. "Systemic concepts in literature and art". Diss., This resource online, 1991. http://scholar.lib.vt.edu/theses/available/etd-07282008-135409/.
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43
Short, Andrew Keith. "Epitope mapping studies in systemic vaculitis". Thesis, University of Cambridge, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338103.
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Russell, Andrew Ian. "Genetic predisposition to systemic lupus erythematosus". Thesis, Imperial College London, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406513.
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Lewis, Graham Matthew. "The genetic basis of systemic autoimmunity". Thesis, University of Oxford, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.424728.
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46
McCandless, Robert. "Developing reflexive abilities in systemic training". Thesis, Birkbeck (University of London), 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.553719.
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47
Hamchaoui, Lara. "A systemic approach to competency management". Thesis, City University London, 2001. http://openaccess.city.ac.uk/7598/.
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Changes in the business environment have in recent years exceeded expectations and challenged the way organisations manage their businesses. Increased concentration in the marketplace following significant changes to the barriers to entry has resulted in organisations seeking to deliver competitive advantage in different ways. Some organisations have tried to strip away at non-core capabilities, redesign their processes and acquire competitors fiercely. Ultimately most of these changes have impacted the employees within the organisations. This systems science research explores the competency approach to employee management. It identifies the environmental changes that have led to such an approach including those within the field of Human Resource Management and discusses the impact of these changes on managing the performance of employees. The thesis explores the recent trend of adopting a competency strategy to concentrate employee behaviour on specific organisational capabilities. The research surveyed Human Resource directors in the UK to gauge their opinion of the difficulties and successes associated with adopting a competency strategy. A Systemic Competency Framework was developed which was initially validated with two case studies. The Systemic Competency Framework proposes a five-stage process that guides Human Resource practitioners through the design, implementation and management of a competency strategy both in an evaluative and design context.
48
Li, Hei Philip, i 李曦. "Subphenotype stratification in systemic lupus erythematosus". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B48334765.
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Subsets of systemic lupus erythematosus (SLE) patients with distinct patterns of disease manifestations and autoantibody production have been reported, but seldom have these two phenomena been analysed together. Cluster analysis was performed on 1928 Chinese SLE patients based on autoantibody profile and the frequencies of various clinical manifestations were compared between each cluster. Separate association analyses between individual autoantibodies and clinical manifestations, as well as between clinical manifestations, were also performed.
This study identifies three separate autoantibody clusters each with different clinical manifestations, and proposes that the phenomena of autoantibody clustering and clinical subsets may be inter-related. Patient clusters could also be stratified into a bipolar spectrum. On one end are patients with over-representation of anti-dsDNA and renal disorder; whilst on the other end are two distinct autoantibody clusters (anti-Sm/anti-RNP/aPL and aPL/anti-Ro/anti-La) with overlapping of other non-renal manifestations. Patient stratification could aid disease prediction and subsequent management. These findings may also elucidate disease pathogenesis and guide future study on potential common pathological processes within autoantibody clusters.published_or_final_version
Paediatrics and Adolescent Medicine
Master
Master of Research in Medicine
49
Yiu, Kai-hang, i 姚啟恆. "Cardiovascular manifestations in systemic inflammatory diseases". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B48541011.
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Systemic inflammatory diseases, including those of rheumatology and dermatology, are associated with increased cardiovascular events. Evidence demonstrates that the chronic systemic inflammation associated with these diseases plays a pivotal role in all stages of atherosclerotic plaque formation, from initiation of the fatty streak to plaque rupture and consequent acute coronary syndrome. Although a number of studies have evaluated the cardiovascular manifestations in systemic inflammatory disease, this thesis offers additional observations, including the vascular atherosclerotic pattern, the pathogenesis of premature atherosclerosis and the use of coronary calcification as a predictor of adverse cardiovascular outcome.
The work is divided into four sections. Section I provides an overview of the cardiovascular manifestation of systemic inflammatory diseases and the patients and methods of the current thesis. The objective of Section II is to evaluate the pattern of cardiovascular manifestation, in particular systemic vascular calcification and cardiac valve calcification in patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and psoriasis, using multi-detector computed tomography (MDCT) and carotid intima-media thickness (c-IMT). It was found that both patients with RA, SLE and psoriasis had a greater prevalence and extent of vascular calcification compared with age and gender matched controls. Moreover, both aortic valve calcification (AVC), mitral valve calcification (MVC) was found to be more prevalent in patients with RA and SLE than controls. Interestingly, the presence of MVC, but not AVC, independently predicted the occurrence of premature atherosclerosis with arterial calcification in these patients.
Section III evaluates the potential underlying mechanisms that lead to cardiovascular manifestations in patients with systemic inflammatory disease. Bone marrow-derived endothelial progenitor cells (EPCs) play an important role in the maintenance of endothelial integrity and hemostasis. The relationship between the circulating EPCs and subclinical coronary atherosclerosis as determined by coronary calcification in RA patients nonetheless remains unclear. The study results demonstrated that RA patients with coronary atherosclerosis have significantly lower levels of CD133/KDR+ and CD133+ EPCs than those without. In addition to older age, lower levels of circulating CD133/KDR+ EPCs also predicted occurrence of coronary atherosclerosis. As with RA and SLE, psoriasis is associated with premature atherosclerosis, although the underlying mechanism remains unclear. The aim of the study was therefore to investigate the relationship of disease activity and systemic inflammation with macrovascular and microvascular function in patients with psoriasis. The results demonstrated that patients with psoriasis have increased arterial stiffness, but not microvascular dysfunction compared with healthy controls. More importantly, high-sensitivity C reactive protein positively correlated with, and independently predicted, arterial stiffness.
Section IV explores the prognostic value of a surrogate marker of atherosclerosis, coronary calcium score (CCS), in patients with RA and SLE. A total of 152 patients with RA (n=85) and SLE (n=69), and 106 healthy controls underwent MDCT to measure CCS. All patients were prospectively followed up for major cardiovascular events for a mean period of 4.3 years. The result demonstrated that presence of CCS >100 predicted the occurrence of a major cardiovascular event independent of other risk factors in RA and SLE patients.published_or_final_version
Medicine
Master
Doctor of Medicine
50
Eltemsahi, Ayman. "A systemic approach to performance measures". Thesis, University of Sunderland, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.341433.
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