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Artykuły w czasopismach na temat „Synthesis of Allocolchicine”

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Data publikacji: 6 września 2023

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Sprawdź 30 najlepszych artykułów w czasopismach naukowych na temat „Synthesis of Allocolchicine”.

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1

Fedorov, Alexey, Ekaterina Shchegravina, Elena Svirshchevskaya i Hans-Günther Schmalz. "A Facile Synthetic Approach to Nonracemic Substituted Pyrrolo-allocolchicinoids Starting from Natural Colchicine". Synthesis 51, nr 07 (13.12.2018): 1611–22. http://dx.doi.org/10.1055/s-0037-1610673.

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A six-step semisynthetic approach towards chiral nonracemic pyrrolo-allocolchicinoids starting from naturally occurring colchicine was developed. The synthetic scheme includes an electrocyclic tropolone ring contraction to afford allocolchicinic acid followed by the Curtius reaction, giving the corresponding aniline. The Sandmeyer reaction and copper-mediated hydrazination gave hydrazine-substituted allocolchicine. This was introduced into the Fischer indole synthesis, affording libraries of regioisomeric indole-based allocolchicine congeners.
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2

Sitnikov, Nikolay S., Alexander V. Sinzov, Diane Allegro, Pascale Barbier, Sebastien Combes, Liliane Abodo Onambele, Aram Prokop, Hans-Günther Schmalz i Alexey Yu Fedorov. "Synthesis of indole-derived allocolchicine congeners exhibiting pronounced anti-proliferative and apoptosis-inducing properties". MedChemComm 6, nr 12 (2015): 2158–62. http://dx.doi.org/10.1039/c5md00320b.

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3

Djurdjevic, Sinisa, Fei Yang i James R. Green. "Intramolecular Nicholas Reactions in the Synthesis of Dibenzocycloheptanes. Synthesis of Allocolchicine NSC 51046 and Analogues and the Formal Synthesis of (−)-Allocolchicine". Journal of Organic Chemistry 75, nr 23 (3.12.2010): 8241–51. http://dx.doi.org/10.1021/jo101953n.

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4

Fedorov, Alexey, Iuliia Gracheva, Elena Svirshchevskaya, Vladimir Faerman i Irina Beletskaya. "Synthesis and Antiproliferative Properties of Bifunctional Allocolchicine Derivatives". Synthesis 50, nr 14 (28.05.2018): 2753–60. http://dx.doi.org/10.1055/s-0037-1610146.

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Based on the natural antimitotic agent colchifoline as a lead structure, a series of novel bifunctional allocolchicine congeners were synthesized from commercial colchicine. The new derivatives maintain good cytotoxicity against T3M4, MiaPaCa-2, and PANC-1 cell lines. The presence of functional groups simplifies further modifications of the prepared structures and the design of novel colchicine-derived antitumor compounds with desired pharmacological properties.
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5

Zotov, A. S., E. S. Shchegravina i A. Yu Fedorov. "Synthesis of Allocolchicine Conjugates with a Cetirizine Analog". Russian Journal of Organic Chemistry 54, nr 10 (październik 2018): 1498–504. http://dx.doi.org/10.1134/s107042801810010x.

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6

Banwell, MG, JM Cameron, M. Corbett, JR Dupuche, E. Hamel, JN Lambert, CM Lin i MF Mackay. "Synthesis and Tubulin-Binding Properties of Some AC- and ABC-Ring Analogs of Allocolchicine". Australian Journal of Chemistry 45, nr 12 (1992): 1967. http://dx.doi.org/10.1071/ch9921967.

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Fourteen analogues [compounds (8), (9) and (11)-(22)] of the powerful antimitotic agent allocolchicine (5) have been prepared and evaluated for their ability to prevent tubulin polymerization. The X-ray structure of one of the more active compounds, tricycle (20), is reported.
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7

Djurdjevic, Sinisa, Fei Yang i James R. Green. "ChemInform Abstract: Intramolecular Nicholas Reactions in the Synthesis of Dibenzocycloheptanes. Synthesis of Allocolchicine NSC 51046 (IVa) and Analogues and the Formal Synthesis of (-)-Allocolchicine (V)." ChemInform 42, nr 11 (17.02.2011): no. http://dx.doi.org/10.1002/chin.201111108.

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8

Joncour, Agnès, Anne Décor, Jian-Miao Liu, Marie-Elise Tran Huu Dau i Olivier Baudoin. "Asymmetric Synthesis of Antimicrotubule Biaryl Hybrids of Allocolchicine and Steganacin". Chemistry - A European Journal 13, nr 19 (25.06.2007): 5450–65. http://dx.doi.org/10.1002/chem.200601764.

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9

Krasniqi, Besir, i Wim Dehaen. "Synthesis of 1,2,3-Triazolo-Fused Allocolchicine Analogs via Intramolecular Oxidative Biaryl Coupling". Organic Letters 21, nr 13 (26.06.2019): 5002–5. http://dx.doi.org/10.1021/acs.orglett.9b01707.

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10

Sitnikov, Nikolay, Janna Velder, Liliane Abodo, Nicole Cuvelier, Jörg Neudörfl, Aram Prokop, Günter Krause, Aleksey Y. Fedorov i Hans-Günther Schmalz. "Total Synthesis of Indole-Derived Allocolchicine Analogues Exhibiting Strong Apoptosis-Inducing Activity". Chemistry - A European Journal 18, nr 38 (27.08.2012): 12096–102. http://dx.doi.org/10.1002/chem.201200083.

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11

Zhang, Yan, Zhenzhi Cai, Julia Struwe, Chanchan Ma, Wangyu Zeng, Xinyi Liao, Min Xu i Lutz Ackermann. "Dibenzocycloheptanones construction through a removable P-centered radical: synthesis of allocolchicine analogues". Chemical Science 12, nr 47 (2021): 15727–32. http://dx.doi.org/10.1039/d1sc05404j.

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12

Sitnikov, Nikolay S., Antonina S. Kokisheva, Georgy K. Fukin, Jörg-Martin Neudörfl, Hannah Sutorius, Aram Prokop, Valery V. Fokin, Hans-Günther Schmalz i Alexey Yu Fedorov. "Synthesis of Indole-Derived Allocolchicine Congeners through Pd-Catalyzed Intramolecular C-H Arylation Reaction". European Journal of Organic Chemistry 2014, nr 29 (4.09.2014): 6481–92. http://dx.doi.org/10.1002/ejoc.201402850.

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13

Paymode, Dinesh J., i Chepuri V. Ramana. "Total Synthesis of (±)-Allocolchicine and Its Analogues Using Co-Catalyzed Alkyne [2 + 2 + 2]-Cyclotrimerization". ACS Omega 2, nr 9 (8.09.2017): 5591–600. http://dx.doi.org/10.1021/acsomega.7b00980.

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14

Vorogushin, Andrei V., Alexander V. Predeus, William D. Wulff i Hans-Jürgen Hansen. "Diels−Alder Reaction−Aromatization Approach toward Functionalized Ring C Allocolchicinoids. Enantioselective Total Synthesis of (−)-7S-Allocolchicine". Journal of Organic Chemistry 68, nr 15 (lipiec 2003): 5826–31. http://dx.doi.org/10.1021/jo034420t.

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15

Schmalz, Hans-Günther, i Norman Nicolaus. "Synthesis of Novel Allocolchicine Analogues with a Pyridine C-Ring through Intermolecular Vollhardt Diyne-Nitrile Cyclotrimerization". Synlett 2010, nr 14 (22.07.2010): 2071–74. http://dx.doi.org/10.1055/s-0030-1258512.

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16

BANWELL, M. G., J. M. CAMERON, M. CORBETT, J. R. DUPUCHE, E. HAMEL, J. N. LAMBERT, C. M. LIN i M. F. MACKAY. "ChemInform Abstract: Synthesis and Tubulin-Binding Properties of Some AC- and ABC-Ring Analogues of Allocolchicine." ChemInform 24, nr 13 (20.08.2010): no. http://dx.doi.org/10.1002/chin.199313279.

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17

Sitnikov, Nikolay S., Antonina S. Kokisheva, Georgy K. Fukin, Joerg-Martin Neudoerfl, Hannah Sutorius, Aram Prokop, Valery V. Fokin, Hans-Guenther Schmalz i Alexey Yu Fedorov. "ChemInform Abstract: Synthesis of Indole-Derived Allocolchicine Congeners Through Pd-Catalyzed Intramolecular C-H Arylation Reaction." ChemInform 46, nr 12 (marzec 2015): no. http://dx.doi.org/10.1002/chin.201512277.

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18

Nicolaus, Norman, i Hans-Guenther Schmalz. "ChemInform Abstract: Synthesis of Novel Allocolchicine Analogues with a Pyridine C-Ring Through Intermolecular Vollhardt Diyne-Nitrile Cyclotrimerization." ChemInform 42, nr 2 (16.12.2010): no. http://dx.doi.org/10.1002/chin.201102204.

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19

Corrie, Tom J. A., i Guy C. Lloyd-Jones. "Formal Synthesis of (±)-Allocolchicine Via Gold-Catalysed Direct Arylation: Implication of Aryl Iodine(III) Oxidant in Catalyst Deactivation Pathways". Topics in Catalysis 60, nr 8 (19.04.2017): 570–79. http://dx.doi.org/10.1007/s11244-017-0742-z.

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Abstract A concise formal synthesis of racemic allocolchicine has been developed, centred on three principal transformations: a retro-Brook alkylation reaction to generate an arylsilane, a gold-catalysed arylative cyclisation to generate the B-ring via biaryl linkage, and a palladium-catalysed carbonylation of an aryl chloride to generate an ester. 1H NMR monitoring of the key gold-catalysed cyclisation step reveals that a powerful catalyst deactivation process progressively attenuates the rate of catalyst turnover. The origins of the catalyst deactivation have been investigated, with an uncatalysed side-reaction, involving the substrate and the iodine(III) oxidant, identified as the source of a potent catalyst poison. The side reaction generates 1–4% of a diaryliodonium salt, and whilst this moiety is shown not to be an innate catalyst deactivator, when it is tethered to the arylsilane reactant, the inhibition becomes powerful. Kinetic modelling of processes run at two different catalyst concentrations allows extraction of the partitioning of the gold catalyst between the substrate and its diaryliodonium salt, with a rate of diaryliodonium salt generation consistent with that independently determined in the absence of catalyst. The high partition ratio between substrate and diaryliodonium salt (5/1) results in very efficient, and ultimately complete, diversion of the catalyst off-cycle. Graphical Abstract
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20

Bhowmik, Subhendu, Shruti Khanna, Kumkum Srivastava, Mohammad Hasanain, Jayanta Sarkar, Sandeep Verma i Sanjay Batra. "An Efficient Combinatorial Synthesis of Allocolchicine Analogues via a Triple Cascade Reaction and their Evaluation as Inhibitors of Insulin Aggregation". ChemMedChem 8, nr 11 (5.09.2013): 1767–72. http://dx.doi.org/10.1002/cmdc.201300302.

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21

Corrie, Tom J. A., i Guy C. Lloyd-Jones. "Correction to: Formal Synthesis of (±)-Allocolchicine Via Gold-Catalysed Direct Arylation: Implication of Aryl Iodine(III) Oxidant in Catalyst Deactivation Pathways". Topics in Catalysis 63, nr 19-20 (24.02.2020): 1766. http://dx.doi.org/10.1007/s11244-020-01243-w.

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22

Bhowmik, Subhendu, Shruti Khanna, Kumkum Srivastava, Mohammad Hasanain, Jayanta Sarkar, Sandeep Verma i Sanjay Batra. "ChemInform Abstract: An Efficient Combinatorial Synthesis of Allocolchicine Analogues via a Triple Cascade Reaction and Their Evaluation as Inhibitors of Insulin Aggregation." ChemInform 45, nr 13 (14.03.2014): no. http://dx.doi.org/10.1002/chin.201413048.

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23

Djurdjevic, Sinisa, i James R. Green. "Allocolchicines via Intramolecular Nicholas Reactions: The Synthesis of NSC 51046". Organic Letters 9, nr 26 (grudzień 2007): 5505–8. http://dx.doi.org/10.1021/ol7024422.

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24

Boyer, François-Didier, i Issam Hanna. "Synthesis of Allocolchicines Using Sequential Ring-Closing Enyne Metathesis−Diels−Alder Reactions". Organic Letters 9, nr 4 (luty 2007): 715–18. http://dx.doi.org/10.1021/ol0630548.

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25

Jain, Nishant, Divya Yada, Thokhir B. Shaik, Galanki Vasantha, P. Surendra Reddy, Shasi V. Kalivendi i B. Sreedhar. "Synthesis and Antitumor Evaluation of Nitrovinyl Biphenyls: Anticancer Agents Based on Allocolchicines". ChemMedChem 6, nr 5 (6.04.2011): 859–68. http://dx.doi.org/10.1002/cmdc.201100019.

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26

Gracheva, Iuliia A., Hans Günther Schmalz, Elena V. Svirshchevskaya, Ekaterina S. Shchegravina i Alexey Fedorov. "Design of an Aryne-Platform for the Synthesis of Non-Racemic Heterocyclic Allocolchicinoids". Organic & Biomolecular Chemistry, 2023. http://dx.doi.org/10.1039/d3ob00827d.

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A four-step semisynthetic approach towards a highly versatile allocolchicine-related chiral aryne intermediate starting from naturally occurring colchicine was developed, and some of its synthetic transformations were studied. The in situ...
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27

"Synthesis of Allocolchicine Analogues through Construction and Removal of P-centered Radicals". Synfacts 18, nr 03 (16.02.2022): 0251. http://dx.doi.org/10.1055/s-0041-1737884.

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28

Pollok, Dennis, Florian U. Rausch, Sebastian B. Beil, Peter Franzmann i Siegfried R. Waldvogel. "Allocolchicines─Synthesis with Electro-organic Key Transformations". Organic Letters, 3.05.2022. http://dx.doi.org/10.1021/acs.orglett.2c01084.

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29

Djurdjevic, Sinisa, i James R. Green. "ChemInform Abstract: Allocolchicines via Intramolecular Nicholas Reactions: The Synthesis of NSC 51046." ChemInform 39, nr 22 (27.05.2008). http://dx.doi.org/10.1002/chin.200822201.

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30

Boyer, Francois-Didier, i Issam Hanna. "Synthesis of Allocolchicines Using Sequential Ring-Closing Enyne Metathesis—Diels—Alder Reactions." ChemInform 38, nr 26 (26.06.2007). http://dx.doi.org/10.1002/chin.200726160.

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