Artykuły w czasopismach na temat „Sweeney, John”

Director John Doyle is one of the foremost re-interpreters of Sondheim’s musicals. His productions of Sweeney Todd and Company introduced the practice of actor–musicianship to UK and US audiences and transformed assumptions about how those shows could be produced. As artistic director of Classic Stage Company (CSC), Doyle directed groundbreaking productions of Assassins and Pacific Overtures; before taking on the leadership of CSC, he directed a re-imagined version of Passion. Doyle also worked with librettist John Weidman and Sondheim to revise what had been Wise Guys and Bounce into Road Show. In this candid and illuminating interview, Doyle discusses his relationship with Sondheim and his approach to Sondheim’s musicals.

IRLAND: EINE GEOGRAPHISCHE LANDESKUNDE, by Helmut Jäger. Darmstadt: Wissenschaftliche Buchgesellschaft, 1990. DM 59. ISBN 3 534 07619 2. Reviewed by ANNGRET SIMMSTHE MODERN INDUSTRIALISATION OF IRELAND 1940–1988, by Liam Kennedy. Studies in Irish Social and Economic History 5 (Economic and Social History Society of Ireland, c/o Department of Modern History, Trinity College, Dublin 2), 1989. 74pp. IR£3.95p. ISSN 0 790 2913. Reviewed by PROINNSIAS BREATHNACHPOCKET GUIDE TO THE IRISH LANDSCAPE, by J.C. Brindley. Belfast: Appletree Press, 1989. 72pp. IR£2.95. ISBN 0 86281 226 7. Reviewed by F.H.A.AALENGEOGRAPHICAL PERSPECTIVES ON THE BELFAST REGION, edited by Paul Doherty. Dublin: Geographical Society of Ireland Special Publications No.5, 1990. 114pp. IR£6.00. ISBN 0 9510402 5 1. Reviewed by JAMES H. JOHNSONTHE IVEAGH TRUST: THE FIRST HUNDRED YEARS.I890–1990, by F.H.A. Aalen. Dublin: The I veagh Trust, 1990.98pp. I R£8.00. ISBN 0 951594206 Reviewed by A.J. PARKERURBANIZATION AND URBAN DEVELOPMENT: RECENT TRENDS AND STRATEGIES IN A GLOBAL CONTEXT, edited by Michael J. Bannon, Larry S. Bourne and Robert Sinclair. Dublin : Service Industries Research Centre, University College Dublin, 1991. 249pp. IR£15.00. ISBN 1870089 43 X. Reviewed by A.J. PARKERTHE IRISH SEA: A RESOURCE AT RISK, edited by John C. Sweeney. Dublin : Geographical Society of Ireland Special Publications No.3, 1989. 192pp. IR£8.00. ISBN 0 9510402 3 5. Reviewed by FRANK OLDFIELDTHE BRITISH SEAS: AN INTRODUCTION TO THE OCEANOGRAPHY AND RESOURCES OF THE NORTH-WEST EUROPEAN CONTINENTAL SHELF, by J. Hardisty. London: Routledge, 1990. 272pp. £35.00 stg. ISBN 0 415 03586 4. Reviewed by JOHN SWEENEY

This article examines depictions of class-encoded agency in the English spy operative and police detective protagonists that appeared on commercial television during the late 1960s and 1970s. Its purpose is to discover connections between constructions of this agency and class-based discourses relating to what Michael Kenny (1995) has termed the ‘first New Left’ (1956–62). The focus of attention is The Sweeney's DI Jack Regan (John Thaw), the most recognisable and fluent expression of the male ‘anti-hero’ archetype in question; but in order to frame an analysis that deals with interrelationships at the level of metanarrative, the article also traces a process of genre interconnection and development. Considerations of class in series such as The Sweeney (ITV, 1975–8), Callan (ITV, 1967–72) and Special Branch (ITV, 1969–74) tend to offer meaning along the lines drawn by the likes of E. P. Thompson, Raymond Williams and Richard Hoggart, as well as other figures associated with the first New Left. The article proposes that key first New Left themes – working-class men finding ‘voice’; empiricism/theory binaries; and discourses of Americanisation and anti-Americanism – not only provide a historical/contextual lens through which to view class-encoded agency, but also constitute a mechanism through which it is expressed.

‘King takes Queen’. This is how John Sweeney summed up his view of the state visit by Romanian President Nicolae Ceausescu to Britain in June 1978, an event which marked the high point of what theTimesreferred to as ‘Britain's political romance with Romania’ in the 1970s. Sweeney's book, in common with other post-revolutionary writing on Romania, roundly condemns Britain's foreign policy-makers for supporting a repressive regime.1However, in the 1970s the situation was not viewed in such clear-cut terms. In the early part of the decade, books by British writers praised Ceausescu, and Romania often received favourable coverage in the British press.2It was almost universally seen as a country which, although internally rigidly communist, pursued an independent foreign policy and was consequently a thorn in the flesh of the Soviet Union. It was keen to industrialise and to expand its economic ties with the West in order to do so. Apologists for British policy would argue that it was therefore both politically and economically beneficial to support Ceausescu. Politically it would weaken Moscow's control over the Eastern Bloc, and economically it would benefit British industry. Indeed, the two were related – the more economic ties Ceausescu had with the West, the stronger his political independence from Moscow would become.

Festival Report: For passionate lovers of silent cinema, the first weekend of October is permanently highlighted in the calendar: it is then that a small city in the north of Italy serves up more than just excellent antipasti and chilled Aperol Spritz. Le Giornate del Cinema Muto, or “the days of silent cinema,” commonly known as the Pordenone Silent Film Festival, has been the mecca for film historians and amateurs of “mute flickers” since its founding in 1982. The festival is the largest silent film festival in the world, offering a nine-day bombardment of rediscoveries, restorations, retrospectives, and special events from dusk until well past dawn, projected at the proper speeds and accompanied by such leading early cinema musicians as Neil Brand, John Sweeney, and Günter Buchwald. Film history comes alive. Films reviewed include: Douro, Faina Fluvial (1931), Chuji tabinikki (A Diary of Chuji's Travels, Daisuke Ito, 1927), and Henri Fescourt's 1925–26 rendition of Les Misérables.

GLOBAL CHANGE AND THE IRISH ENVIRONMENT, edited by John Sweeney. Dublin: Royal Irish Academy and Irish Committee for International Geosphere-Biosphere Programme, 1997. 170pp. IR£10.00pb. ISBN 1 874045 50 X. Reviewed by ROY TOMLINSONCLIMATES OF THE BRITISH ISLES: PRESENT, PAST AND FUTURE, edited by Mike Hulme and Elaine Barrow. London: Routledge, 1997. 439pp. £17.99stg. ISBNO- 415-13017-4(pb). REGIONAL CLIMATES OF THE BRITISH ISLES, edited by Dennis Wheeler and Julian Mayes. London: Routledge, 1997. 343pp. £17.99stg. ISBN 0-415- 13931-7 (pb). Reviewed by GERALD MILLSPROPERTY OWNERSHIP AND URBAN AND VILLAGE IMPROVEMENT IN PROVINCIAL IRELAND c. 1700-1845, by Lindsay Proudfoot. [British] Historical Geography Research Group, Historical Geography Research Series, No.33,1997. 105pp. £7.95stg. ISBN I 87007415 7. Reviewed by MARK HENNESSYDOWNPATRICK, by Ronald Buchanan and Anthony Wilson. Fascicle No.8, Irish Historic Towns Atlas, edited by A. Simms, H.B. Clarke and R. Gillespie. Dublin: Royal Irish Academy, 1997. 16pp. text+ 8 maps+2 plates. IR£18.00. ISBN 0-874045-33-X. Reviewed by MARK HENNESSYTHEM AND US?: ATTITUDINAL VARIATION AMONG CHURCHGOERS IN BELFAST, by Frederick W. Boal, Margaret C. Keane and David N. Livingstone. Belfast: Institute of Irish Studies, Insight Series No.l, 1997. 240pp. ISBN 0-85389- 679-8. Reviewed by ARNOLD HORNER

HOWELL: Violin Sonata in F minor; Rosalind for violin & piano; Piano Sonata in E minor; Humoresque for piano; 5 Studies for piano. Lorraine McAslan (vln), Sophia Rahman (pno). Dutton Epoch CDLX 7144.BACEWICZ: Violin Sonatas Nos. 4–5; Oberek No. 1; Sonata No. 2 for violin solo; Partita; Capriccio; Polish Capriccio. Joanna Kurkowicz (v;n), Gloria Chien (pno). Chandos CHAN 10250.MARIC: Byzantine Concerto1; Cantata: Threshold of Dream2,3,6; Ostinato Super Thema Octoïcha4–6; Cantata: Song of Space7. 1Olga Jovanovic (pno), Belgrade PO c. Oskar Danon, 2Dragoslava Nikolic (sop, alto), 3Jovan Milicevic (narr), 4Ljubica Maric (pno), 5Josip Pikelj (hp), 6Radio-TV Belgrade CO c. Oskar Danon, 7Radio-TV Belgrade Mixed Choir & SO c. Mladen Jagušt. Chandos Historical 10267H.MUSGRAVE: For the Time Being: Advent1; Black Tambourine2–3; John Cook; On the Underground Sets1–3. 1Michael York (narr), 2Walter Hirse (pno), 3Richard Fitz, Rex Benincasa (perc),New York Virtuoso Singers c. Harold Rosenbaum. Bridge 9161.KUI DONG: Earth, Water, Wood, Metal, Fire1; Pangu's Song2; Blue Melody3; Crossing (electronic/computer tape music); Three Voices4. 1Sarah Cahill (pno), 2Tod Brody (fl), Daniel Kennedy (perc), 3San Francisco Contemporary Music Players c. Olly Wilson, 4Hong Wang (Chinese fiddle), Ann Yao (Chinese zither), Chen Tao (bamboo fl). New World 80620-2.FIRSOVA: The Mandelstam Cantatas: Forest Walks, op. 36; Earthly Life, op. 31; Before the Thunderstorm, op. 70. Ekaterina Kichigina (sop), Studio for New Music Moscow c. Igor Dronov. Megadisc MDC 7816.KATS-CHERNIN: Ragtime & Blues. Sarah Nicholls (pno). Nicola Sweeney (vln). Signum SIGCD058.CHAMBERS: A Mass for Mass Trombones. Thomas Hutchinson (trb), Ensemble of 76 trombones c. David Gilbert. Centaur CRC 2263.

Abstract Introduction: Despite evidence that utilization of Electronic Medical Record (EMR) messaging positively impacts patients with cancer, there is little research on who uses EMR messaging and for what purpose. Methods: Sociodemographic and MyChart usage data was collected from Epic to identify patterns of EMR messaging by patients at an academic breast center. Study eligibility included breast cancer patients who completed a visit and sent at least one message to a provider during the study period (May 2021- May 2022). Chi-square and t-tests were used to describe differences between users and non-users of EMR messaging. ANOVA and chi-square were used to describe differences between race/ethnicity. Analyses were performed in R version 4.2 and p< 0.05 was considered statistically significant. Results: A total of 4069 patients who had MyChart account activated were included in the analysis sample. Of those, 3575 (87.9%) were messaging users and 494 (12.1%) were non-users. The mean age of users was significantly lower compared to the non-users (57.7 vs 61.2, p< .001). There were statistically significant racial/ethnic differences (p< 0.001) by user status with 83.9% and 9.5% of users being non-Hispanic White (NHW) and non-Hispanic Black (NHB) respectively. Among non-users 69.6% were NHW and 21.1% were NHB. There were also significant differences in preferred language (p< 0.001) and payor (p< 0.001) by user status. 99.2% of users were English speaking and 96.8% of non-users were non-English speaking. 54% and 38%, and 6.5% of users had Managed care, Medicare, and Medicaid respectively as their payor. Whereas 36.9%, 51%, and 10.5% of non-users had Managed care, Medicare, and Medicaid respectively. Lastly, there were statistically significant racial/ethnic differences in the types of messages sent among EMR users. Conclusions: There are significant differences in race/ethnicity among EMR users and non-users, and racial/ethnic differences in the types of messages sent among EMR messaging users. We believe that these differences may be in part due to disparities in access or comfort in using EMR. Future directions include conducting interviews with minority patients who are users and non-users of EMR messaging to identify barriers and gaps in use. Table 1. Patient Characteristics. Characteristics of users and non-users of EMR messaging. Chi-square and T-test for significance were performed to assess the difference between groups. P< .05 was considered significant. Table 2. Message Type by Race/Ethnicity. Types of message sent by race/ethnicity. ANOVA and chi-square were used to describe differences between race/ethnicity and type of message sent. P< .05 was considered significant. Citation Format: Meghan Conroy, Miracle Powell, Sneha Nagavally, Aprill Dawson, Anna Beckius, Heun Min, Maressa Sweeney, Elizabeth Weil, Angela Hallbach, Lubna N. Chaudhary, Yee Chung Cheng, Jutta Deiinger, John Burfeind, Janet Retseck, Tamiah Wright, John Charlson, Sailaja Kamaraju. Addressing Healthcare Gaps and Disparities in Electronic Medical Record Messages: A Quality Improvement Project Among Breast Cancer Patients [abstract]. In: Proceedings of the 2022 San Antonio Breast Cancer Symposium; 2022 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2023;83(5 Suppl):Abstract nr P6-05-52.

Purpose – This paper observes that Apple illustrates the right and wrong ways to bring about organizational change, and emphasizes the key role of personalities in the process. Design/methodology/approach – Compares and contrasts the performance of Apple under the leadership of Steve Jobs and John Sculley. Findings – Advances the view that Steve Jobs was more successful because he focused on innovation, while John Sculley paid more attention to current products and profitability. Practical implications – Describes how the Steve Jobs era saw the introduction of such iconic Apple products as the iPod, iPhone and iPad, which helped the company to gain pre-eminence in its field. Social implications – Argues that, in today’s globalized business environment, organizational change is a must. Demonstrates how to achieve this successfully. Originality/value – Describes two sides of the Apple story and draws the lessons for other businesses involved in organizational change.

Abstract Background: Advances in cancer treatment have led to the rise of targeted therapies as practice-changing modalities, demonstrating significant efficacy in molecularly selected patients. However, depth of response and survival benefit is variable. Limitations in radiographic imaging create challenges in determining a clinical response. Circulating tumor DNA (ctDNA) is a promising minimally-invasive, predictive biomarker. Here we explore the utility of tumor-informed, on-treatment ctDNA dynamics for early response monitoring and prognostication in patients with HER2-positive tumors of various histologies receiving trastuzumab + pertuzumab on the phase II basket trial, MyPathway (NCT02091141). Methods: In this retrospective study, 58 patients were included based on availability of tissue comprehensive genomic profiling (CGP) results and baseline/on-treatment plasma. FoundationOne® Tracker was utilized to detect and quantify ctDNA, selecting 2-16 tumor-derived variants from tissue CGP and monitoring the corresponding patient’s plasma with multiplex PCR. ctDNA was assessed at baseline and Cycle 3 Day 1 (C3D1) of therapy. Correlations between ctDNA changes and objective response, progression-free survival (PFS) and overall survival (OS) were made using Kaplan Meier analyses and landmarked at C3D1. Patients ctDNA- at baseline and C3D1 were excluded. Results: Of the 58 patients, personalized ctDNA assays were successfully designed for 52 (89.7%) representing 14 unique tumor histologies. Of 52, 48 (92.3%) had ctDNA results available for baseline analysis with a median of 100.7 mean tumor molecules per mL (MTM/mL); 89.6% were ctDNA+ with a median of 119.5 MTM/mL. A total of 39 patients had both baseline and C3D1 results for ctDNA response analyses. On-treatment ctDNA decline >90% (N=10) was associated with longer survival compared to <90% decline (N=16) or any increase (N=13) in ctDNA (OS: NR, 9.4 months (mo); P= 0.007). CtDNA dynamics remained predictive in a disease specific analysis of colorectal cancer (N=18; OS: NR, 10.2 mo; P= 0.04). Similar results were seen when stratifying patients by baseline ctDNA level (above/below median MTM/mL) or HER2 (ERBB2) mutation vs amplification. ctDNA increase at C3D1 preceded radiographic progression by a median of 1.3 mo. In patients with stable disease, >90% decline in ctDNA was associated with longer OS compared to <90% decline or any increase (NR, 9.4 mo; P= 0.01). Conclusion: Tumor-informed ctDNA monitoring provides insight into early treatment response and survival outcomes in patients with diverse HER2 amplified or mutated tumors receiving HER2 targeted therapy. On-treatment ctDNA dynamics refine and can potentially detect response/progression ahead of standard of care response assessments, suggesting early ctDNA monitoring as a valuable complementary tool for real-time treatment response monitoring. Citation Format: Razelle Kurzrock, Merrida Childress, Wenshu Li, Anna Muse, Julia Malato, Yong Wang, Minetta Liu, Alexey Aleshin, Richard S. Wang, Julia Thierauf, Christopher J. Sweeney, John Hainsworth, Tania Szado, Amanda Young, Katja Schulze, David Spigel, Funda Meric-Bernstam, Charles Swanton, Howard A. Burris. Tumor informed circulating tumor DNA monitoring for early treatment response and survival outcomes on trastuzumab + pertuzumab [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 1209.

Abstract Background: Malignant pleural mesothelioma (MPM) is usually fatal, though multimodality therapy— now including immunotherapy— has improved survival. Recurrence after surgery is close to 100%, even with adjuvant chemotherapy and radiation. Our collaborators have performed deep immunophenotyping of treatment-naïve MPM lesions using mass cytometry (CyTOF) and single-cell RNA sequencing (scRNAseq) to define the tumor microenvironment. A population of rare CD141+ dendritic cells (DC1) is disproportionately represented in some MPM lesions analyzed. These DC1 cells— which express high levels of Toll-like receptor 3 (TLR3)— are among the most potent cross-presenters of antigen and are key to priming anti-tumor CD4+ and CD8+ T cell responses. Polyinosinic-polycytidylic acid stabilized with polylysine and carboxymethylcellulose (poly-ICLC), is a double-stranded RNA host-targeted therapeutic viral-mimic. Poly-ICLC activates multiple innate immune receptors including TLR3 and melanoma differentiation-associated gene 5 (MDA5), leading to cross-presentation of antigen to T cells and induction of strong Th1 response. We hypothesize that injection of poly-ICLC prior to surgical resection may activate intratumoral (IT) DC1s, increase tumor antigen presentation to cytotoxic T cells, and induce tumor-specific immune surveillance. Methods: This is a phase I/Ib study to evaluate the safety of IT poly-ICLC prior to surgical resection for patients with MPM (NCT04525859). The primary endpoint is safety as assessed by frequency and severity of toxicities by CTCAE 5.0. Secondary endpoints are objective response as measured by RECIST 1.1 and recurrence free survival measured from the time of first poly-ICLC injection. Exploratory endpoints include evaluation of circulating immune cells (including regulatory T cells and NK cells), evaluation of immune cell infiltration in pre-injection tumor biopsy and surgically resected tissue, as well as characterization of immune parameters such as local B cell specificity. The protocol features a Simon’s two-stage design, with six patients enrolled in a phase I safety cohort, proceeding to a phase Ib expansion cohort (additional 13 patients) if no more than 1 dose limiting toxicity occurs. Eligible patients must have MPM deemed operable by the treating thoracic surgeon. Eligible subjects may not have uncontrolled immunocompromised states or autoimmune disorders. After enrollment, patients undergo biopsies at which time 2mg poly-ICLC is injected across two sites in the tumor. Patients then undergo resection of the tumor (pleurectomy/decortication or extra pleural pneumonectomy per standard of care) at day 21+/- 7 after poly-ICLC injection. Blood is drawn at three points (prior to poly-ICLC injection, at time of surgery, and at a post-operative visit) for immune profiling. At the time of submission six patients have been treated and phase Ib accrual is continuing as planned. Interim analysis of phase I safety and exploratory endpoints will be reported in late 2022. Citation Format: Bailey G. Fitzgerald, Thomas U. Marron, Robert Sweeney, Jorge Gomez, Nicole Hall, Daniel O'Grady, Christian Rolfo, Raj Veluswamy, Deborah Doroshow, John Mandeli, David Yankelevitz, Nina Bhardwaj, Sacha Gnjatic, Fred R. Hirsch, Miriam Merad, Alexander Tsankov, Raja Flores, Andrea Wolf. A phase I/Ib trial of intratumoral Poly-ICLC in resectable malignant pleural mesothelioma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr CT205.

Abstract Background: Esophageal adenocarcinoma (EAC) is a leading cause of cancer-related mortality. Sitravatinib is a small molecule spectrum-selective tyrosine kinase inhibitor (TKI) that targets TAM receptors (AXL, MERTK and TYRO3), VEGF, PDGF, and c-Kit. Previously, dual inhibition of TAM and VEGF receptors has shown to successfully modulate the tumor immune microenvironment towards a less immunosuppressive state, by depletion of MDSCs and repolarization of TAMs towards a proinflammatory M1 phenotype. In clinical trials, TKIs have shown to improve patient outcomes, alone or in combination with immune checkpoint inhibitors, in multiple solid tumors. In the present study, the antitumor activity of sitravatinib alone and in combination with PD-1 blockade was investigated in a de novo EAC rat model. Methods: Ninety-six rats underwent an end-to-side esophagojejunostomy to induce gastroesophageal reflux, resulting in EAC carcinogenesis. At 32 weeks post-operatively, tumor bearing animals were randomized to a dose of 10mg/kg of sitravatanib (S) or vehicle control (VC), for a total of three 14 day cycles. A PD-1 inhibitor, AUNP-12 (IO), was administered at a dose of 3mg/kg or placebo, on day 12 of each cycle. At 38 weeks post-operatively animals were euthanized. Safety and efficacy was evaluated by on-treatment mortality, MRI, immunofluorescence and qRT PCR. Results: The S+/-IO groups demonstrated a higher mortality when compared to the control groups (p<0.001). Pre- to post-treatment, mean MRI tumor volume decreased by 32% and 73% in the S-IO and S+IO and increased by 90% and 160% in the VC+IO and VC-IO, respectively (p<0.001). Enhanced CD3+CD8+ T-cell densities were observed in the treatment groups when compared to the control groups (p<0.001). Additionally, a higher CD86/CD206 ratio was observed in the S-IO and S+IO groups than in the control groups (p<0.001), indicating a repolarization from M2 to M1 macrophage phenotype. Gene expression analysis of post treatment samples demonstrated upregulation of pro-inflammatory cytokines TNF-α, IFN-γ, IL-1β, IL-6, IL-12 and downregulation of anti-inflammatory cytokines including TGF-β, IL-4, IL-10, and IL-13 in the treated versus control animals (p<0.05). Pre- to post-treatment qRT-PCR levels demonstrated significant inhibition of pathway genes, AXL, AKT, MERTK and PI3K, in the treated animals (p=<0.001). Moreover, pre-treatment AXL levels were significantly higher in major responders (>80% tumor reduction n=8) compared to the non-responders (<25% tumor reduction/progression n=6), in the merged S +/- IO group (p=0.009). Lastly, increased apoptosis and decreased proliferation were confirmed through Cas-3 and Ki-67, respectively, in both treatment groups (p<0.001). Conclusion: This study establishes a promising combination strategy using the multi-gene TKI sitravatinib to overcome PD-1/PD-L1 resistance and potentiate immune checkpoint inhibition in an EAC model. Citation Format: Ryan W. Sweeney, John T. Fitzpatrick, Ashten N. Omstead, Ping Zheng, Anastasia Gorbunova, Patrick L. Wagner, Juliann E. Kosovec, Blair A. Jobe, Ronan J. Kelly, Ali H. Zaidi. Sitravatanib enhances immune checkpoint blockade in a de novo esophageal adenocarcinoma model [abstract]. In: Proceedings of the AACR Special Conference: Tumor Immunology and Immunotherapy; 2022 Oct 21-24; Boston, MA. Philadelphia (PA): AACR; Cancer Immunol Res 2022;10(12 Suppl):Abstract nr B60.

Abstract Purpose: Alectinib is FDA-approved for ALK-positive, metastatic non-small cell lung cancer (NSCLC). We analyzed alectinib treatment in a pan-tumor population with ALK alterations from MyPathway (NCT02091141), a multi-basket study assessing approved therapies in non-indicated advanced solid tumors with relevant alterations. Methods: Enrolled patients (pts) were ≥18 yrs old and had metastatic tumors with ALK gene rearrangements, putative activating non-synonymous ALK mutations, and/or ALK gene amplification. Pts received alectinib 600 mg PO BID. The primary endpoint was investigator-assessed objective response rate (ORR; complete response [CR] + partial response [PR]). Other endpoints included duration of response (DOR), disease control rate (DCR; CR + PR + stable disease [SD] >4 mos), progression-free survival (PFS), and safety. Results: By the 11-18-2021 data cutoff, 21 pts with various tumor types had been enrolled and treated (ALK mutations or amplification, n=11 [52.4%]; ALK rearrangements +/- other ALK alterations, n=10 [47.6%]). Pts had a median of 2 (range, 1-5) prior lines of therapy. In the 10 pts with ALK rearrangements, there were 3 PRs (30.0%) with a median DOR of 6.8 mos (Table). An additional 3 pts in this group had SD >4 mos; DCR was 60.0% (6/10). In contrast, there were no responses among the 11 pts with ALK mutations or amplification. Confirmed ORR for the entire group was 14.3% (3/21), and DCR was 42.9% (9/21). Median PFS was 8.2 mos in pts with ALK rearrangements vs 1.8 mos for those with other ALK alterations. Alectinib-related adverse events (AEs) were observed in 85.7% of pts, with 3 (14.3%) experiencing grade 3 AEs (anemia; hypokalemia; and changes in AST, ALT, and/or blood creatinine levels). AEs were consistent with the known alectinib safety profile. Conclusions: Although the number of pts is small, alectinib appears active in those with non-NSCLC advanced solid tumors with ALK rearrangements. As in NSCLC, cancers with ALK mutations or amplification were not responsive to ALK inhibition. Table. Clinical outcomes Clinical Response Rearrangement (n=10) Mutation (n=7) Amplification (n=4) Median PFS, mos (all alterations) n Indications n Indications n Indications PR 3a Melanoma, Papillary urothelial carcinoma, Colon adenocarcinoma 0 NA 0 NA 9.3 SD >4 mos 3b,c Colon adenocarcinoma, Uterine leiomyosarcoma, Pancreatic adenocarcinoma 2 Squamous cell carcinoma, Soft tissue sarcoma 1 Uterine body clear cell carcinoma 5.7 SD ≤4 mos 0 NA 1 Fallopian tube serous carcinoma 0 NA PD 3d,e Colon adenocarcinoma, Esophageal adenocarcinoma, Uterine serous carcinoma 4 Anaplastic thyroid carcinoma, Esophageal adenocarcinoma, Colon adenocarcinoma (2) 3 Ovarian serous carcinoma, Gastric squamous cell carcinoma, Peritoneal non-small cell carcinoma 1.7 Non-evaluable 1f Uterine inflammatory myofibroblastic tumor 0 NA 0 NA NA aFusion gene partners: EMILIN1, DCTN1, and DIAPH2. bOne pt with ALK rearrangement and SD >4 mos also had ALK amplification. cFusion gene partners: STRN, IGFBP5, and EML4. dPts with ALK rearrangement and PD also had an ALK mutation (n=1) or ALK amplification (n=1). eFusion gene partner: STRN; fusion genes unknown for 2 pts. fPt withdrew prior to clinical assessment and was censored for PFS at 0.03 mos. NA, not applicable; PD, progressive disease; PFS, progression-free survival; PR, partial response; SD, stable disease. Citation Format: Charles Swanton, Claire F. Friedman, Christopher J. Sweeney, Funda Meric-Bernstam, David Spigel, Ron Bose, Howard Burris, Walter C. Darbonne, Julia Malato, Jonathan Levy, Yong Wang, Tania Szado, Katja Schulze, John Hainsworth, Razelle Kurzrock. Activity and safety of alectinib for ALK-altered solid tumors from MyPathway [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr CT032.

buy this issueThe publication last month of The Age of Monopoly Capital: The Selected Correspondence of Paul A. Baran and Paul M. Sweezy, 1949–1964, edited by Nicholas Baran and John Bellamy Foster, constitutes a landmark for Monthly Review Press. A historical document in itself, The Age of Monopoly Capital is not simply about the writing of their magnum opus, but also provides a window onto an entire era of American life.Click here to purchase a PDF version of this article at the Monthly Review website.

Abstract This essay argues that thinking about university futures requires not only practices of critique and desire, but practices of rigorous and reflexive imagination. Building on Bill Sharpe's three horizons framework, it argues that debates about university futures are dominated by horizon 1 thinking (critique of the current situation) and horizon 3 thinking (normative aspirations toward desirable futures) but that there is limited exploration of horizon 2 (the emerging possibilities that may create radical disruption). The article draws on futures and anticipation studies, in particular Ziauddin Sardar and John Sweeney's “postnormal menagerie,” to model a set of imaginative inquiries into the blind spots, blank spots, and different forms of ignorance through which highly divergent university futures might be explored. It concludes by proposing two scenarios for university futures—the “Campus of the Sky” and the “Pirate University”—as sites of generative experimentation and further research, and with a call for a radical diversification of participation in dialogues about the future of the university.

Abstract The aim of the study was to evaluate the influence of 1-methylcyclopropene (1-MCP) treatment and ultra-low oxygen (ULO) storage conditions on the sensory characteristics of apples. Two apple storage technologies were tested in this study: cold storage under traditional conditions in combination with 1-MCP treatment, and ULO storage with two different compositions of a gas mixture. Apples were stored for 6 months. After storage, the sensory characteristics were analysed. Sensory evaluation showed that storage technology affected the sensory characteristics and panelists’ acceptability. Distinctive differences were found between apples stored under controlled atmosphere and traditional conditions. Trained panelists highlighted that samples stored under controlled atmosphere had pronounced juiciness and color, while 1-MCP-treated apples stored in cold were sweeter and more aromatic. Apples of the autumn cultivar ‘Auksis’, was perceived considerably higher after harvest and before long-term storage, compared with other cultivars. During 6 months of storage in controlled atmosphere, the sensory quality of these apples remained intact. Also, the sensory quality of fruit of the winter cultivar ‘Sinap Orlovskij’ throughout 6 months of its storage in controlled atmosphere remained intact. Besides, it was noticed that apples stored in controlled atmosphere were juicier and more aromatic with intense color. There is a positive effect of 1-MCP treatment on maintenance of apple quality stored in normal atmosphere for 6 months. With regard to some quality parameters and sensory attributes, 1-MCP-treated apples stored under normal atmosphere are comparable to those stored under ULO conditions.

Those of you with a sweet tooth are no doubt already familiar with the delicious doughnut, but did you know there is much more to that simple pastry than meets the eye? Here’s an experiment: take a sheet of A4 paper and roll it up, now try to join the two open ends without bending or making any corners on the paper, go on I’ll wait…..impossible right? Well that’s because we are stuck with only three dimensions, add in one more dimension though and you can! What’s more is that if we lived on the surface of that doughnut, the world would look a lot like the surface of the Earth does to us now-flat as far as the eye can see (but a lot sweeter if you choose to eat the soil). My research is on understanding all these ‘flat’ doughnuts (called tori in mathematics) and how to make ...

According to John Goodby and Marcella Edwards, ‘many Irish poets in the 1960s and 1970s turned to translation from Irish in a way that suggests the difficulty of coming to terms with rapid modernization’. Although this may sound like a reasonable conclusion to make of a period of significant social, cultural and economic upheaval, Goodby and Edwards rely on a false binary in their assertion. Referred to by Joe Cleary as the ‘repression-modernization dyad’ through which ‘all sorts of things get drastically simplified’, this is the notion that a clean break was effected by the transfer of power from Éamon de Valera to Seán Lemass in the late 1950s; that traditionalism and economic nationalism were replaced wholesale by dynamism and economic progressivism. According to such an unnuanced view of mid-century Ireland, then, the ‘difficulty’ faced by those poets who turned to translation from Irish appears to be the difficulty of reconciling traditional literary categories with the onslaught of a modernising agenda which apparently reserved no space for them. This article problematises such a ‘drastically simplified’ account by arguing that poetic translations from Irish in the Lemass years and shortly thereafter played a variety of conflicting cultural roles, as opposed to merely articulating the complexities of rapid economic and social change. The crux of such a claim revolves around a paradox in mid-century Ireland: namely, the persistence of what Raymond Williams would call ‘residual’ nationalism, which jarred with the expansionist economic agenda of the Lemass government. As such, this article juxtaposes Thomas Kinsella’s Tain (1969) with Trevor Joyce’ The Poems of Sweeny Peregrine (1976) to illustrate how some texts proved amenable to the state’s newfound ‘paradoxical conflation of the “economy” and the “nation”’, as Conor McCarthy puts it, while others sought to expose the ‘contradictions and gaps within Irishness as it is now’.

Financial information is one of the important information in decision making. However, many cases of fraud committed by management so that the information in the financial statements cannot be relied upon in decision making. Therefore, the auditor's job is to ensure that the company's financial statements are represented correctly (faithful representation) so that financial statement information becomes more quality and useful in making decisions. So this study aims to examine the effect of audit fee on audit quality. In addition, this study also examines important determinants of audit costs, namely company size, profitability, audit risk, complexity, and firm size. By using the purposive sampling method, samples of the financial and manufacturing industry in 2010-2017 used are 39 firms per year. This sample is used to examine the effect of audit fee on audit quality and the determinant of audit fee using simple linear regression analysis and multiple linear regression analysis. 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This short essay reflects on the process of running a Causal Layered Analysis scenario exercise with the Institute for Professional Development at the Academy of Public Administration in Kazakhstan in collaboration with John Sweeney (from the then Qazaq Research Institute for Futures Studies). We worked with approximately 50 public administrators over a 3 day period, culminating in a Causal Layered Analysis scenario process that challenged and reviewed the national vision. The process surfaced fundamental dynamics and tensions in national identity and representation. The findings and process are detailed here.

p. 1 The proceedings of the house of parlament the 13th April 1640. The first Ceremony is the riding to the Abbey. The King & Lords in state [in the House of Lords]. Then the Kings speech recommends a Speaker. Then the house of Commons & offer the Speaker [Sir John Glanville] the chayre whoe makes many delays & excuses & at last takes it. Then the house is adiourned till the 15:th of April. The oaths of Supremacy & alleageance adminnistered by the Earle Marshall to as many as were present. Then a Commission to Some of them to sweere the rest, which all men must take ere they sitt in the house.

Introduction Children are not only born digital, they are fashioned toward a lifestyle that needs them to be digital all the time (Palfrey and Gasser). They click, tap, save, circulate, download, and upload the texts of their lives, their friends’ lives, and the anonymous lives of the people that surround them. They are socialised as Internet consumers ready to participate in digital services targeted to them as they age such as Snapchat, Instagram, and YouTube. But they are also fashioned as producers, whereby their lives are sold as content on these same markets. As commodities, the minutiae of their lives become the fodder for online circulation. Paradoxically, we also celebrate these digital behaviours as a means to express identity. Personal profile-building for adults is considered agency-building (Beer and Burrows), and as a consequence, we praise children for mimicking these acts of adult lifestyle. This article reflects on the Kids, Creative Storyworlds, and Wearables project, which involved an ethnographic study with five young children (ages 4-7), who were asked to share their autobiographical stories, creative self-narrations, and predictions about their future mediated lives (Atkins et al.). For this case study, we focus on commercialised forms of children’s automedia, and we compare discussions we had with 6-year old Cayden, a child we met in the study who expresses the desire to make himself famous online, with videos of Jacob, a child vlogger on YouTube’s Kinder Playtime, who clearly influences children like Cayden. We argue that child social influencers need consideration both as autobiographical agents and as child subjects requiring a sheltered approach to their online lives.Automedia Automedia is an emergent genre of autobiography (Smith and Watson Reading 190; “Virtually Me” 78). Broadcasting one’s life online takes many forms (Kennedy “Vulnerability”). Ümit Kennedy argues “Vlogging on YouTube is a contemporary form of autobiography in which individuals engage in a process of documenting their life on a daily or weekly basis and, in doing so, construct[ing] their identity online” (“Exploring”). Sidonie Smith and Julia Watson write that “visual and digital modes are projecting and circulating not just new subjects but new notions of subjectivity through the effects of automediality” with the result that “the archive of the self in time, in space and in relation expands and is fundamentally reorganized” (Reading 190). Emma Maguire addresses what online texts “tell us about cultural understandings of selfhood and what it means to communicate ‘real’ life through media” naming one tool, “automedia”. Further, Julie Rak calls on scholars “to rethink ‘life’ and ‘writing’ as automedia” to further “characterize the enactment of a personal life story in a new media environment.” We define automedia as a genre that involves the practices of creating, performing, sharing, circulating, and (at times) preserving one’s digital life narrative meant for multiple publics. Automedia revises identity formation, embodiment, or corporealities in acts of self-creation (Brophy and Hladki 4). Automedia also emphasizes circulation. As shared digital life texts now circulate through the behaviours of other human subjects, and automatically via algorithms in data assemblages, we contend that automediality currently involves a measure of relinquishing control over perpetually evolving mediatised environments. One cannot control how a shared life narrative will meet a public in the future, which is a revised way of thinking about autobiography. For the sake of this paper, we argue that children’s automedia ought to be considered a creative, autobiographical act, in order to afford child authors who create them the consideration they deserve as agents, now and in the future. Automedial practices often begin when children receive access to a device. The need for a distraction activity is often the reason parents hand a young child a smartphone, iPad, or even a wearable camera (Nansen). Mirroring the lives of parents, children aspire to share representations of their own personal lives in pursuit of social capital. They are often encouraged to use technologies and apps as adults do–to track aspects of self, broadcast life stories and eventually “live share” them—effectively creating, performing, sharing, and at times, seeking to preserve a public life narrative. With this practice, society inculcates children into spheres of device ubiquity, “socializing them to a future digital lifestyle that will involve always carrying a computer in some form” (Atkins et al. 49). Consequently, their representations become inculcated in larger media assemblages. Writing about toddlers, Nansen describes how the “archiving, circulation and reception of these images speaks to larger assemblages of media in which software protocols and algorithms are increasingly embedded in and help to configure everyday life (e.g. Chun; Gillespie), including young children’s media lives (Ito)” (Nansen). Children, like adult citizens, are increasingly faced with choices “not structured by their own preferences but by the economic imperatives of the private corporations that have recently come to dominate the internet” (Andrejevic). Recent studies have shown that for children and youth in the digital age, Internet fame, often characterized by brand endorsements, is a major aspiration (Uhls and Greenfield, 2). However, despite the ambition to participate as celebrity digital selves, children are also mired in the calls to shield them from exposure to screens through institutions that label these activities detrimental. In many countries, digital “protections” are outlined by privacy commissioners and federal or provincial/state statutes, (e.g. Office of the Privacy Commissioner of Canada). Consequently, children are often caught in a paradox that defines them either as literate digital agents able to compose or participate with their online selves, or as subjectified wards caught up in commercial practices that exploit their lives for commercial gain.Kids, Creative Storyworlds and Wearables ProjectBoth academic and popular cultural critics continually discuss the future but rarely directly engage the people who will be empowered (or subjugated) by it as young adults in twenty years. To address children’s lack of agency in these discussions, we launched the Kids, Creative Storyworlds and Wearables project to bring children into a dialogue about their own digital futures. Much has been written on childhood agency and participation in culture and mediated culture from the discipline of sociology (James and James; Jenks; Jenkins). In previous work, we addressed the perspective of child autobiographical feature filmmakers to explore issues of creative agency and consent when adult gatekeepers facilitate children in film production (Pedersen and Aspevig “My Eyes”; Pedersen and Aspevig “Swept”). Drawing on that previous work, this project concentrates on children’s automediated lives and the many unique concerns that materialize with digital identity-building. Children are categorised as a vulnerable demographic group necessitating special policy and legislation, but the lives they project as children will eventually become subsumed in their own adult lives, which will almost certainly be treated and mediated in a much different manner in the future. We focused on this landscape, and sought to query the children on their futures, also considering the issues that arise when adult gatekeepers get involved with child social media influencers. In the Storyworlds ethnographic study, children were given a wearable toy, a Vtech smartwatch called Kidizoom, to use over a month’s timeframe to serve as a focal point for ethnographic conversations. The Kidizoom watch enables children to take photos and videos, which are uploaded to a web interface. Before we gave them the tech, we asked them questions about their lives, including What are machines going to be like in the future? Can you imagine yourself wearing a certain kind of computer? Can you tell/draw a story about that? If you could wear a computer that gave you a super power, what would it be? Can you use your imagination to think of a person in a story who would use technology? In answering, many of them drew autobiographical drawings of technical inventions, and cast themselves in the images. We were particularly struck by the comments made by one participant, Cayden (pseudonym), a 6-year-old boy, and the stories he told us about himself and his aspirations. He expressed the desire to host a YouTube channel about his life, his activities, and the wearable technologies his family already owned (e.g. a GroPro camera) and the one we gave him, the Kidizoom smartwatch. He talked about how he would be proud to publically broadcast his own videos on YouTube, and about the role he had been allowed to play in the making of videos about his life (that were not broadcast). To contextualize Cayden’s commentary and his automedial aspirations, we extended our study to explore child social media influencers who broadcast components of their personal lives for the deliberate purpose of popularity and the financial gain of their parents.We selected the videos of Jacob, a child vlogger because we judged them to be representative of the kinds that Cayden watched. Jacob reviews toys through “unboxing videos,” a genre in which a child tells an online audience her or his personal experiences using new toys in regular, short videos on a social media site. Jacob appears on a YouTube channel called Kinder Playtime, which appears to be a parent-run channel that states that, “We enjoy doing these things while playing with our kids: Jacob, Emily, and Chloe” (see Figure 1). In one particular video, Jacob reviews the Kidizoom watch, serving as a child influencer for the product. By understanding Jacob’s performance as agent-driven automedia, as well as being a commercialised, mediatised form of advertising, we get a clearer picture of how the children in the study are coming to terms with their own digital selfhood and the realisation that circulated, life-exposing videos are the expectation in this context.Children are implicated in a range of ways through “family” influencer and toy unboxing videos, which are emergent entertainment industries (Abidin 1; Nansen and Nicoll; Craig and Cunningham 77). In particular, unboxing videos do impact child viewers, especially when children host them. Jackie Marsh emphasizes the digital literacy practices at play here that co-construct viewers as “cyberflâneur[s]” and she states that “this mode of cultural transmission is a growing feature of online practices for this age group” (369). Her stress, however, is on how the child viewer enjoys “the vicarious pleasure he or she may get from viewing the playing of another child with the toy” (376). Marsh writes that her study subject, a child called “Gareth”, “was not interested in being made visible to EvanHD [a child celebrity social media influencer] or other online peers, but was content to consume” the unboxing videos. The concept of the cyberflâneur, then, is fitting as a mediatising co-constituting process of identity-building within discourses of consumerism. However, in our study, the children, and especially Cayden, also expressed the desire to create, host, and circulate their own videos that broadcast their lives, also demonstrating awareness that videos are valorised in their social circles. Child viewers watch famous children perform consumer-identities to create an aura of influence, but viewers simultaneously aspire to become influencers using automedial performances, in essence, becoming products, themselves. Jacob, Automedial Subjects and Social Media InfluencersJacob is a vlogger on YouTube whose videos can garner millions of views, suggesting that he is also an influencer. In one video, he appears to be around the age of six as he proudly sits with folded hands, bright eyes, and a beaming, but partly toothless smile (see Figure 2). He says, “Welcome to Kinder Playtime! Today we have the Kidi Zoom Smartwatch DX. It’s from VTech” (Kinder Playtime). We see the Kidi Zoom unboxed and then depicted in stylized animations amid snippets of Jacob’s smiling face. The voice and hands of a faceless parent guide Jacob as he uses his new wearable toy. We listen to both parent and child describe numerous features for recording and enhancing the wearer’s daily habits (e.g. calculator, calendar, fitness games), and his dad tells him it has a pedometer “which tracks your steps” (Kinder Playtime). But the watch is also used by Jacob to mediate himself and his world. We see that Jacob takes pictures of himself on the tiny watch screen as he acts silly for the camera. He also uses the watch to take personal videos of his mother and sister in his home. The video ends with his father mentioning bedtime, which prompts a “thank you” to VTech for giving him the watch, and a cheerful “Bye!” from Jacob (Kinder Playtime). Figure 1: Screenshot of Kinder Playtime YouTube channel, About page Figure 2: Screenshot of “Jacob,” a child vlogger at Kinder Playtime We chose Jacob for three reasons. First, he is the same age as the children in the Storyworlds study. Second, he reviews the smart watch artifact that we gave to the study children, so there was a common use of automedia technology. Third, Jacob’s parents were involved with his broadcasts, and we wanted to work within the boundaries of parent-sanctioned practices. However, we also felt that his playful approach was a good example of how social media influence overlaps with automediality. Jacob is a labourer trading his public self-representations in exchange for free products and revenue earned through the monetisation of his content on YouTube. It appears that much of what Jacob says is scripted, particularly the promotional statements, like, “Today we have the Kidizoom Smartwatch DX. It’s from VTech. It’s the smartest watch for kids” (Kinder Playtime). Importantly, as an automedial subject Jacob reveals aspects of his self and his identity, in the manner of many child vloggers on public social media sites. His product reviews are contextualised within a commoditised space that provides him a means for the public performance of his self, which, via YouTube, has the potential to reach an enormous audience. YouTube claims to have “over a billion users—almost one-third of all people on the Internet—and every day people watch hundreds of millions of hours on YouTube and generate billions of views” (YouTube). Significantly, he is not only filmed by others, Jacob is also a creative practitioner, as Cayden aspired to become. Jacob uses high-tech toys, in this case, a new wearable technology for self-compositions (the smart watch), to record himself, friends, family or simply the goings-on around him. Strapped to his wrist, the watch toy lets him play at being watched, at being quantified and at recording the life stories of others, or constructing automediated creations for himself, which he may upload to numerous social media sites. This is the start of his online automediated life, which will be increasingly under his ownership as he ages. To greater or lesser degrees, he will later be able to curate, add to, and remediate his body of automedia, including his digital past. Kennedy points out that “people are using YouTube as a transformative tool, and mirror, to document, construct, and present their identity online” (“Exploring”). Her focus is on adult vloggers who consent to their activities. Jacob’s automedia is constructed collaboratively with his parents, and it is unclear how much awareness he has of himself as an automedia creator. However, if we don’t afford Jacob the same consideration as we afford adult autobiographers, that the depiction of his life is his own, we will reduce his identity performance to pure artifice or advertisement. The questions Jacob’s videos raise around agency, consent, and creativity are important here. Sidonie Smith asks “Can there be a free, agentic space; and if so, where in the world can it be found?” (Manifesto 188). How much agency does Jacob have? Is there a liberating aspect in the act of putting personal technology into the hands of a child who can record his life, himself? And finally, how would an adult Jacob feel about his childhood self advertising these products online? Is this really automediality if Jacob does not fully understand what it means to publicly tell a mediated life story?These queries lead to concerns over child social media influence with regard to legal protection, marketing ethics, and user consent. The rise of “fan marketing” presents a nexus of stealth marketing to children by other children. Stealth marketing involves participants, in this case, fans, who do not know they are involved in an advertising scheme. For instance, the popular Minecon Minecraft conference event sessions have pushed their audience to develop the skills to become advocates and advertisers of their products, for example by showing audiences how to build a YouTube channel and sharing tips for growing a community. Targeting children in marketing ploys seems insidious. Marketing analyst Sandy Fleisher describes the value of outsourcing marketing to fan labourers:while Grand Theft Auto spent $120 million on marketing its latest release, Minecraft fans are being taught how to create and market promotional content themselves. One [example] is Minecraft YouTuber, SkydoesMinecraft. His nearly 7 million strong YouTube army, almost as big as Justin Bieber’s, means his daily videos enjoy a lot of views; 1,419,734,267 to be precise. While concerns about meaningful consent that practices like this raise have led some government bodies, and consumer and child protection groups to advocate restrictions for children, other critics have questioned the limits placed on children’s free expression by such restrictions. Tech commentator Larry Magid has written that, “In the interest of protecting children, we sometimes deny them the right to access material and express themselves.” Meghan M. Sweeney notes that “the surge in collaborative web models and the emphasis on interactivity—frequently termed Web 2.0—has meant that children are not merely targets of global media organizations” but have “multiple opportunities to be active, critical, and resistant producers”...and ”may be active agents in the production and dissemination of information” (68). Nevertheless, writes Sweeney, “corporate entities can have restrictive effects on consumers” (68), by for example, limiting imaginative play to the choices offered on a Disney website, or limiting imaginative topics to commercial products (toys, video games etc), as in YouTube review videos. Automedia is an important site from which to consider young children’s online practices in public spheres. Jacob’s performance is indeed meant to influence the choice to buy a toy, but it is also meant to influence others in knowing Jacob as an identity. He means to share and circulate his self. Julie Rak recalls Paul John Eakin’s claims about life-writing that the “process does not even occur at the level of writing, but at the level of living, so that identity formation is the result of narrative-building.” We view Jacob’s performance along these lines. Kinder Playtime offers him a constrained, parent-sanctioned (albeit commercialised) space for role-playing, a practice bound up with identity-formation in the life of most children. To think through the legality of recognising Jacob’s automedial content as his life, Rak is also useful: “In Eakin’s work in particular, we can see evidence of John Locke’s contention that identity is the expression of consciousness which is continuous over time, but that identity is also a product, one’s own property which is a legal entity”. We have argued that children are often caught in the paradox that defines them either as literate digital creators composing and circulating their online selves or as subjectified personas caught up in commercial advertising practices that use their lives for commercial gain. However, through close observation of individual children, one who we met and questioned in our study, Cayden, the other who we met through his mediated, commercialized, and circulated online persona, Jacob, we argue that child social influencers need consideration as autobiographical agents expressing themselves through automediality. As children create, edit, and grow digital traces of their lives and selves, how these texts are framed becomes increasingly important, in part because their future adult selves have such a stake in the matter: they are being formed through automedia. Moreover, these children’s coming of age may bring legal questions about the ownership of their automedial products such as YouTube videos, an enduring legacy they are leaving behind for their adult selves. Crucially, if we reduce identity performances such as unboxing, toy review videos, and other forms of children’s fan marketing to pure advertisement, we cannot afford Jacob and other child influencers the agency that their self representation is legally and artistically their own.ReferencesAbidin, Crystal. “#familygoals: Family Influencers, Calibrated Amateurism, and Justifying Young Digital Labor.” Social Media + Society 3.2 (2017): 1-15.Andrejevic, Mark. “Privacy, Exploitation, and the Digital Enclosure.” Amsterdam Law Forum 1.4 (2009). <http://amsterdamlawforum.org/article/view/94/168>.Atkins, Bridgette, Isabel Pedersen, Shirley Van Nuland, and Samantha Reid. “A Glimpse into the Kids, Creative Storyworlds and Wearables Project: A Work-in-Progress.” ICET 60th World Assembly: Teachers for a Better World: Creating Conditions for Quality Education – Pedagogy, Policy and Professionalism. 2017. 49-60.Beer, David, and Roger Burrows. “Popular Culture, Digital Archives and the New Social Life of Data.” Theory, Culture & Society 30.4 (2013): 47–71.Brophy, Sarah, and Janice Hladki. 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