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Gotowe bibliografie tematyczne / Surfactant-Protein System - Drug Delivery

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Gotowa bibliografia na temat „Surfactant-Protein System - Drug Delivery”

Autor: Grafiati

Data publikacji: 7 września 2023

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Artykuły w czasopismach na temat "Surfactant-Protein System - Drug Delivery"

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Suttee, Ashish, Vijay Mishra, Pallavi Nayak, Manvendra Singh i Pavani Sriram. "Niosomes: Potential Nanocarriers for Drug Delivery". INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE 11, nr 03 (25.09.2020): 389–94. http://dx.doi.org/10.25258/ijpqa.11.3.13.

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Niosomes are novel vesicular drug delivery systems, where the solution is surrounded by non-ionic surfactant vesicles. The niosomes offer different benefits over the traditional drug delivery system. Niosomes are structurally similar to liposomes, as they also consist of a bilayer. In the case of niosomes, the bilayer consists of non-ionic surface-active agents instead of phospholipids, as seen in liposomes. Niosomes are much more stable during the process of formulation and storage, as compared to liposomes. Niosomes may resolve the issues of insolubility, volatility, poor bioavailability, and rapid drug degradation. It has been discovered in recent years that, these vesicles can enhance drug bioavailability and can act as a new strategy to deliver many conventional therapeutic agents, such as, protein drugs, and gene materials. It is also easy to prepare and scale up this novel delivery system with low production costs. The delivery of drugs via niosomal formulations may be relevant to several pharmacological agents for their activity against different diseases. The present review provides an overview about the advantages and disadvantages, fabrication techniques, types, characterization technique, and different applications of niosomes.

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Rahiman Mohammed Noor Hazira i M Sunitha Reddy. "Niosomes: A nanocarrier drug delivery system". GSC Biological and Pharmaceutical Sciences 22, nr 2 (28.02.2023): 120–27. http://dx.doi.org/10.30574/gscbps.2023.22.2.0062.

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Novel approaches in the drug delivery system can be used for drug targeting in which the drug gets distributed in the body in such a manner that drug interacts with the target tissue. Niosomes are a type of novel drug delivery system in which the medication is encapsulated in a vesicle. Niosomes are a non-ionic surfactant based multilamellar or unilamellar vesicles in which a fluid arrangement of solute is completely enclosed by a membrane because of the association of surfactant macromolecules as a bilayer. Niosomes release the drug in a controlled manner through its bilayer. Niosomes can be used to carry both the amphiphilic and lipophilic drugs. Niosomes have a great potential in targeted drug delivery of anticancer and anti-infective agents. Niosomes are used to modify the drug release profile, drug absorption, distribution and elimination for the benefit of improving product efficacy and safety and improving patient convenience and compliance. They are very small and microscopic. Although they are structurally similar to liposomes, they offer several advantages over them. Niosomes are stable, less toxic and less expensive than liposomes. This review article represents the structure of Niosomes, its advantages and disadvantages, applications, method of preparation, and characterization techniques of Niosomes.

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Ray, Sudhir Kumar, Nargish Bano, Tripti Shukla, Neeraj Upmanyu, Sharad P. Pandey i Geeta Parkhe. "Noisomes: as novel vesicular drug delivery system". Journal of Drug Delivery and Therapeutics 8, nr 6 (15.11.2018): 335–41. http://dx.doi.org/10.22270/jddt.v8i6.2029.

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Target-specific drug-delivery systems for the administration of pharmaceutical compounds enable the localization of drugs to target sites within the body. The basic component of drug delivery systems is an appropriate carrier that protects the drug from rapid degradation or clearance and thereby enhances drug concentration in target tissues. Niosome are microscopic non-ionic surfactant bilayer vesicles obtained on hydration of synthetic nonionic surfactants, with or without incorporation of cholesterol or their lipids. The amphiphilic nature of niosomes promotes their efficiency in encapsulating lipophilic or hydrophilic drugs. Noisome are promising vehicle for drug delivery and being non-ionic, more stable, inexpensive, biodegradable, biocompatible, non immunogenic and exhibit flexibility in their structural characterization. Various additives in niosomes include nonionic surfactant as film forming agent, cholesterol as stabilizing and rigidizing agent for the bilayer and various charge inducers which develop a charge on the surface of niosomes and stabilize the prepared formulation by the resulting repulsive forces. Niosomes have been widely evaluated for controlled release and targeted delivery for the treatment of cancer, viral infections, microbial diseases, psoriasis, leishmaniasis, migraine, parkinson and other diseases. Niosomes can prolong the circulation of the entrapped drug in body. Encapsulation of drug in vesicular system can be predicted to prolong the existence of drug in the systemic circulation and enhance penetration into target tissue, perhaps reduce toxicity if selective uptake can be achieved. In addition to conventional, oral and parenteral routes, they are amenable to be delivered by ocular, transdermal, vaginal and inhalation routes. Delivery of biotechnological products including vaccine delivery with niosomes is also an interesting and promising research area. More concerted research efforts, however, are still required to realize the full potential of these novel systems. This review article focuses on the concept of niosomes, advantages and disadvantages, composition, method of preparation, separation of unentrapped drug, factors influencing the niosomal formulation and characterization, marketed formulations of niosomes and also gives up to date information regarding recent applications of niosomes in drug delivery. Keyword: Drug-delivery system, Niosomes,

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VERMEHREN, C., S. FROKJAER, T. AURSTAD i J. HANSEN. "Lung surfactant as a drug delivery system". International Journal of Pharmaceutics 307, nr 1 (3.01.2006): 89–92. http://dx.doi.org/10.1016/j.ijpharm.2005.10.029.

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Bindhani, Sabitri, S. Mohapatra i R. K. Kar. "Self Emulsifying Drug Delivery System: A Recent Approach". Asian Journal of Chemistry 31, nr 4 (27.02.2019): 751–59. http://dx.doi.org/10.14233/ajchem.2019.21569.

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In recent years, nearly 40 % newer drugs compounds are hydrophobic in nature, which is a major challenge now-a-days for oral drug delivering due to low aqueous solubility. Lipid based drug delivery system is one of the favourable approach for poorly soluble compounds which can improve the drug absorption and oral bioavailability. Due to ion-pairing with appropriate surfactant and co-surfactant the macromolecular drug molecular oil droplet being found in the gut flow oral absorption which sufficiently stable towards lipase. Due to the formation of emulsified drug in micron level, it can efficiently endow the oral bioavailability. Several comprehensive papers have been published in the literature illustration diverse type of lipid based formulation with recent advancements. This article is based on an exhaustive and updated review on newer technology which out line an explicit discussion on its formulations and industrial scale up.

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Wankhade, Vikrant P., Nivedita S. Kale i K. K. Tapar. "Self Microemulsifying Nutraceutical and Drug Delivery Systems". International Journal of Pharmaceutical Sciences and Nanotechnology 7, nr 3 (31.08.2014): 2520–28. http://dx.doi.org/10.37285/ijpsn.2014.7.3.3.

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Many chemical entities and nutraceuticals are poor water soluble and show high lipophilicity. It’s difficult to formulate them into oral formulation because of its low aqueous solubility which ultimately affects bioavailability. To enhance the bioavailability of such drugs compounds, self microemulsifying drug delivery system is the reliable drug delivery system. In this system the drug is incorporated in the isotropic system and formulated as unit dosage form. Self microemulsifying drug delivery system is the novel emulsified system composed of anhydrous isotropic mixture of oils, surfactant, and co solvent and sometimes co surfactant. Drug is directly dispersed into the entire gastro intestinal tract with continuous peristaltic movement and drug is available in the solution form of microemulsion, absorbed through lymphatic system and bypasses the dissolution step. Hence they increase the patient compliance. The excipients are selected on basis of construction of ternary phase diagram. Self micro-emulsifying drug delivery system is very useful for drug in which drug dissolution is rate limiting step. This review describes the novel approaches and evaluation parameters of the self microemulsifying drug delivery system towards different classic drugs, proteins-peptides, and nutraceuticals in various oral microemulsion compositions and microstructures.

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Minakshee G. Nimbalwar, Bhushan R. Gudalwar, Wrushali A. Panchale, Ashish B. Wadekar, Jagdish V. Manwar i Ravindra L. Bakal. "An overview of characterizations and applications of proniosomal drug delivery system". GSC Advanced Research and Reviews 7, nr 2 (30.05.2021): 025–34. http://dx.doi.org/10.30574/gscarr.2021.7.2.0095.

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Proniosomal drug delivery system is a stable provesicular system in nanotechnology to overcome the drawbacks associated with other vesicular systems. These are water-soluble pro-vesicular drug carriers coated with a non-ionic surfactant which on hydration give niosomes. The system is encapsulated and shows a systemic and targeted delivery of poorly soluble drugs with increased bioavailability and decreased side effects. Here we have covered characterizations and applications of the proniosomal drug delivery system.

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Vidhya, Beebireddy, Amarapalli Divya, Makka Mounica i Bhargav Bhongiri. "Non-ionic surfactant carrier/vesicle drug delivery system". International Journal of Multidisciplinary Research and Growth Evaluation 4, nr 2 (2023): 149–55. http://dx.doi.org/10.54660/.ijmrge.2023.4.2.149-155.

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Niosomes are one of the prominent Novel Drug Delivery systems. Niosomes are made up of non-ionic surfactants with or without cholesterol. Primarily niosomes are similar to liposomes in terms of physical properties but differ in chemical nature. Due to their higher chemical stability of surfactants than lipids these are unsurpassed when compared with liposomes. As niosomes are amphiphilic they can be utilized as a carrier for both lipophilic, and hydrophilic drugs. The application of niosomes is widely varied and can be used to treat several diseases like cancer, leishmaniasis, Parkinson, Psoriasis disease, etc. This review focuses on all aspects of niosomes including their historical development, structural components, types, formulation techniques, factors affecting their formation, controlling the size, separation of unentrapped materials, characterization, therapeutic potentials, and stability.

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Kalra, Naresh, i G. Jeyabalan. "Formulation and In-Vitro Evaluation of Niosomal drug Delivery in Cancer Chemotherapy". Indian Journal of Pharmaceutical and Biological Research 5, nr 04 (31.12.2017): 29–33. http://dx.doi.org/10.30750/ijpbr.5.4.6.

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Drug delivery systems are defined as formulations aim for transportation of a drug to the desired area of action within the body. The aim of the study was to investigate the feasibility of using Niosomes as a drug delivery system for Cisplatin By entrapment of drug in Niosomes, dose also could be reduced. Niosomes were prepared by Ethanol injection method using cholesterol and Surfactant. Particle size, zeta potential, entrapment efficiency and in vitro drug release studies were performed. The targeted niosome delivery system is composed of drug, surfactant and cholesterol. With regard to the influence of formulation variables on the percent drug loading (PDL), different compositions with varying ratios of surfactant and cholesterol were studied. In –Vitro drug release mechanism was studied for 24 hours.

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Mishra, Amul, Ridhi Panola i A. C. Rana. "Microemulsions: As drug delivery system". Journal of Scientific and Innovative Research 3, nr 4 (25.08.2014): 467–74. http://dx.doi.org/10.31254/jsir.2014.3412.

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Microemulsions are excellent candidates as potential drug delivery systems because of their improved drug solubilization, long shelf life, and ease of preparation and administration. The formulation of microemulsion for pharmaceutical use requires a thorough understanding of the properties, uses, and limitations of microemulsion. Three distinct microemulsions – oil external, water external and middle phase can be used for drug delivery, depending upon the type of drug delivery upon the type of drug and the site of action. In this article, Since the term ‘microemulsion’ was first coined almost fifty years ago to describe clear, isotropic, thermodynamically stable systems composed of oil, water, surfactant and cosurfactant, numerous and varied reports of the applications of microemulsions have appeared in the literature. Reports of the use of microemulsions in separation science began to appear in the literature in the early 1990’s when they were first used as mobile phases for HPLC and as carrier electrolytes for CE separations, particularly for pharmaceutical applications.

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Rozprawy doktorskie na temat "Surfactant-Protein System - Drug Delivery"

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Beier, Anne Mette. "Chitosan microparticles as a drug delivery system for protein vaccines /". [Cph.] : Pharmexa A/S : Department of Pharmaceutics, The Royal Danish School of Pharmacy, 2002. http://www.dfh.dk/phd/defences/annemettebeier.htm.

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Misak, Heath Edward. "Pre-clinical treatment of skin cancer by magnetic-protein nanocomposite drug delivery system". Diss., Wichita State University, 2011. http://hdl.handle.net/10057/5152.

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Skin cancer affects many people worldwide and is life threatening without treatment. People with light skin, genetic diseases, and high exposure to ultraviolet radiation (UVR) are at a high risk of developing skin cancer. Once developed, skin cancer can spread to the rest of the body, including organs inside the body. If the cancer is established, it is difficult to control and treat. Skin cancer is diagnosed by the depth at which it has spread below the skin. Conventional treatments such as creams and lotions treat only the outer skin surface, while cancer below the skin is allowed to thrive. Treating only the outer layer and not the inner layer of skin can make it difficult to diagnose cancer because the severity of it can be hidden. The ideal treatment is to treat cancer from the inside out. Administering common cancer medicines means killing healthy cells as well as cancer cells; therefore, developing a drug delivery system (DDS), which can be injected into the body and release medicine at an engineered rate and location, is needed. In this thesis, a special drug delivery system is proposed—one that lessens the toxicity of a therapeutic agent from an intraperitoneal (IP) injection by reducing diffusion of that injection into sensitive areas of the body. This DDS uses both magnetic forces to hold it at the affected location and also a protein, encapsulated into the DDS, to reduce an immune response. The protein can also encourage uptake of the DDS into the cancer cell where the DDS releases the therapeutic agent. It is shown that this DDS is successful in treating cancer, and no toxic effects were found, which makes this treatment a possible alternative to conventional therapies.
Thesis (Ph.D.)--Wichita State University, College of Engineering, Dept. of Mechanical Engineering

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Lei, Xia. "Study of Zwitterionic Functionalized Materials for Drug Delivery and Protein Therapeutics". University of Akron / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=akron1555511296878391.

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Whitmire, Rachel Elisabeth. "Self-assembling polymeric nanoparticles for enhanced intra-articular anti-inflammatory protein delivery". Diss., Georgia Institute of Technology, 2012. http://hdl.handle.net/1853/43587.

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The goal of this thesis was to develop a new drug-delivering material to deliver anti-inflammatory protein for treating OA. Our central hypothesis for this work is that a controlled release/presentation system will more effectively deliver anti-inflammatory protein therapies to the OA joint. The primary goal of this work was to synthesize a block copolymer that could self-assemble into injectable, sub-micron-scale particles and would allow an anti-inflammatory protein, IL-1ra, to be tethered to its surface for efficient protein delivery. The block copolymer incorporated an oligo-ethylene monomer for tissue compatibility and non-fouling behavior, a 4-nitrophenol group for efficient protein tethering, and cyclohexyl methacrylate, a hydrophobic monomer, for particle stability. We engineered the copolymer and tested it in both in vitro culture experiments and an in vivo model to evaluate protein retention in the knee joint. The rationale for this project was that the rational design and synthesis of a new drug- and protein-delivering material can create a modular polymer particle that can deliver multi-faceted therapies to treat OA. This work characterizes the in vitro and in vivo behavior of our polymer particle system. The protein tethering strategy allows IL-1ra protein to be tethered to the surface of these particles. Once tethered, IL-1ra maintains its bioactivity and actively targets synoviocytes, cells crucial to the OA pathology. This binding happens in an IL-1-dependent manner. Furthermore, IL-1ra-tethered particles are able to inhibit IL-1beta-induced NF-kappaB activation. These studies show that this particle system has the potential to deliver IL-1ra to arthritic joints and that it has potential for localizing/targeting drugs to inflammatory cells of interest as a new way to target OA drug treatments.

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Ishikawa, Raga. "Development of Engineered Extracellular Vesicle-Liposome Hybrid Using Baculovirus-Expression System". Doctoral thesis, Kyoto University, 2021. http://hdl.handle.net/2433/263686.

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Pilgrová, Tereza. "Příprava a charakterizace koloidů hyaluronanu s micelárními agregáty pro nanomedicínské aplikace". Doctoral thesis, Vysoké učení technické v Brně. Fakulta chemická, 2018. http://www.nusl.cz/ntk/nusl-371153.

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This thesis deals with the study of preparation and characterization of hyaluronan-micelle aggregates. The theoretical part deals with drug delivery systems, characterization of used materials and methods especially fluorescence spectroscopy, dynamic light scattering and turbidimetry. Methods of determination of measured data are summarized in the experimental section. The result section is divided into two subsections dedicated to different preparation methods of hyaluronan-surfactant complexes. Induced aggregates of hyaluronan with Septonex are characterized in terms of their origin and stability, and the results are compared with previously studied surfactants CTAB. In the second part are discussed so-called decorated micelles, their formation, properties and stability.

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Attarhaie, Tehrani Mahtab. "Anatomical Expression and Functional Role of the G-Protein Coupled Estrogen Receptor 1 in the Song System of Zebra Finches (Taeniopygia guttata)". Kent State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=kent152416406994131.

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Squire, Marie A. "Protein-based drug delivery systems". Thesis, University of Canterbury. Chemistry, 2004. http://hdl.handle.net/10092/6518.

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The targeted delivery of drugs is one of the most actively pursued goals in anti-HIV and anti-cancer chemotherapy. This project takes a proof-of-concept approach to the development of protein-based drug delivery systems - delivery systems that would package, target, and deliver cytotoxins to diseased cells. Primarily, this project explores the use of the potent anti-HN protein, cyanovirin-N (CV-N), to actively target and deliver cytotoxic natural products to HN-infected cells. This project also investigates the use of human serum albumin (HSA), a 66 kDa protein, as a macromolecular carrier to passively target and deliver cytotoxic natural products to cancerous cells. To facilitate release of the toxin within infected cells, an enzymatically-cleavable tetra peptide was incorporated in the conjugates. Maleimido-activated tetra peptide toxin constructs were prepared in readiness for selective reaction with proteins carrying thiol functionalities. Release of the toxin, norhomohalichondrin B, was demonstrated in vitro. Native CV -N conjugates were prepared by thiolation of the lysine ε-amino groups, and the subsequent reaction with maleimido-activated compounds. Reaction across all lysine residues was demonstrated. A singly-substituted tyrosinamide conjugate of CV-N was prepared. Two recombinantly produced mutant CV-N proteins allowed for the production of selectively modified, double- and single-norhomohalichondrin B conjugates of CV-N. The conjugates retained the anti-HN activity of the parent protein. Homohalichondrin B, doxorubicin, and tyrosinamide conjugates of HSA were prepared. The syntheses exploited the availability of a free thiolmoiety at cysteine-34 of HSA, and the specific and selective reaction of this thiol with the maleimido-activated tetra peptide derivatives. All toxin conjugates demonstrate excellent cell toxicity. Further research to investigate whether this is targeted toxicity is currently underway.

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Mawad, Damia Graduate School of Biomedical Engineering Faculty of Engineering UNSW. "Development of Novel hydrogels for protein drug delivery". Awarded by:University of New South Wales. Graduate School of Biomedical Engineering, 2005. http://handle.unsw.edu.au/1959.4/25221.

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Introduction: Embolic agents are used to block blood flow of hypervascular tumours, ultimately resulting in target tissue necrosis. However, this therapy is limited by the formation of new blood vessels within the tumour, a process known as angiogenesis. Targeting angiogenesis led to the discovery of anti-angiogenic factors, large molecular weight proteins that can block the angiogenic process. The aim of this research is development of poly (vinyl alcohol) (PVA) aqueous solutions that cross-link in situ to form a hydrogel that functions as an embolic agent for delivery of macromolecular drugs. Methods: PVA (14 kDa, 83% hydrolysed), functionalised by 7 acrylamide groups per chain, was used to prepare 10, 15, and 20wt% non-degradable hydrogels, cured by UV or redox initiation. Structural properties were characterised and the release of FITCDextran (20kDa) was quantified. Degradable networks were then prepared by attaching to PVA (83% and 98 % hydrolysed) ester linkages with an acrylate end group. The effect on degradation profiles was assessed by varying parameters such as macromer concentration, cross-linking density, polymer backbone and curing method. To further enhance the technology, radiopaque degradable PVA was synthesised, and degradation profiles were determined. Cell growth inhibition of modified PVA and degradable products were also investigated. Results: Redox initiation resulted in non-degradable PVA networks of well-controlled structural properties. Increasing the solid content from 10 to 20wt% prolonged the release time from few hours to ~ 2 days but had no effect on the percent release, with only a maximum release of 65% achieved. Ester attachment to the PVA allowed flexibility in designing networks of variable swelling behaviors and degradation times allowing ease of tailoring for specific clinical requirements. Synthesis of radiopaque degradable PVA hydrogels was successful without affecting the polymer solubility in water or its ability to polymerize by redox. This suggested that this novel hydrogel is a potential liquid embolic with enhanced X-ray visibility. Degradable products had negligible cytotoxicity. Conclusion: Novel non-degradable and radiopaque degradable PVA hydrogels cured by redox initiation were developed in this research. The developed PVA hydrogels showed characteristics in vitro that are desirable for the in vivo application as release systems for anti-angiogenic factors.

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Chittchang, Montakarn Johnston Thomas P. "Effect of secondary structure on paracellular transport of polypeptides". Diss., UMK access, 2004.

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Thesis (Ph. D.)--School of Pharmacy and Dept. of Chemistry. University of Missouri--Kansas City, 2004.
"A dissertation in pharmaceutical sciences and chemistry." Advisor: Thomas P. Johnston. Typescript. Vita. Description based on contents viewed Feb. 23, 2006; title from "catalog record" of the print edition. Includes bibliographical references (leaves 202-223). Online version of the print edition.

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Książki na temat "Surfactant-Protein System - Drug Delivery"

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M, Sanders Lynda, i Hendren R. Wayne, red. Protein delivery: Physical systems. New York: Plenum Press, 1997.

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L, Audus Kenneth, i Raub Thomas J, red. Biological barriers to protein delivery. New York: Plenum Press, 1993.

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1961-, McNally Eugene J., red. Protein formulation and delivery. New York: M. Dekker, 2000.

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Peptide and protein delivery. London: Academic Press, 2011.

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P, Torchilin V., red. Delivery of protein and peptide drugs in cancer. London: Imperial College, 2006.

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Alfred Benzon Symposium (43rd 1997 Royal Danish Academy of Sciences and Letters). Peptide and protein drug delivery: Proceedings of a symposium held at the Royal Danish Academy of Sciences and Letters, August 17-21, 1997 : Alfred Benzon Symposium 43. Redaktorzy Christrup Lona, Frøkjær Sven 1947- i Krogsgaard-Larsen Povl. Copenhagen: Munksgaard, 1998.

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Müller, Gerhard, i Bert Klebl. Protein kinases as drug targets. Weinheim: Wiley-VCH, 2011.

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NATO Advanced Research Workshop on Advanced Drug Delivery Systems for Peptides and Proteins (1986 Copenhagen, Denmark). Delivery systems for peptide drugs. New York: Plenum Press, 1986.

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Lee, Vincent H. L., 1951-, Hashida Mitsuru i Mizushima Yutaka, red. Trends and future perspectives in peptide and protein drug delivery. Chur, Switzerland: Harwood Academic, 1995.

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1958-, Cohen Smadar, i Bernstein Howard 1957-, red. Microparticulate systems for the delivery of proteins and vaccines. New York: Marcel Dekker, 1996.

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Części książek na temat "Surfactant-Protein System - Drug Delivery"

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Gohil, Dipti, i Theivasanthi Thirugnanasambandan. "Nanocarriers in Protein and Peptide Drug Delivery". W Nanocarriers: Drug Delivery System, 349–65. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-33-4497-6_14.

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Nakahara, Yuichi, Yuta Endo i Ippei Inoue. "Construction Protocol of Drug-Protein Cage Complexes for Drug Delivery System". W Methods in Molecular Biology, 335–47. New York, NY: Springer US, 2023. http://dx.doi.org/10.1007/978-1-0716-3222-2_19.

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Prokop, Ales, Evgenii Kozlov, Gianluca Carlesso i Jeffrey M. Davidson. "Hydrogel-Based Colloidal Polymeric System for Protein and Drug Delivery: Physical and Chemical Characterization, Permeability Control and Applications". W Filled Elastomers Drug Delivery Systems, 119–73. Berlin, Heidelberg: Springer Berlin Heidelberg, 2002. http://dx.doi.org/10.1007/3-540-45362-8_3.

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Wang, Jin-Ye, Hua-Jie Wang i Xin-Ming Liu. "Protein Microspheres from Corn as a Sustained Drug Delivery System". W ACS Symposium Series, 209–41. Washington, DC: American Chemical Society, 2008. http://dx.doi.org/10.1021/bk-2008-0992.ch012.

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Shoyele, Sunday A. "Engineering Protein Particles for Pulmonary Drug Delivery". W Drug Delivery Systems, 149–60. Totowa, NJ: Humana Press, 2008. http://dx.doi.org/10.1007/978-1-59745-210-6_7.

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Narváez, Alfredo R., i Shyam V. Vaidya. "Protein—Surfactant Interactions at the Air-Water Interface". W Excipient Applications in Formulation Design and Drug Delivery, 139–66. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-20206-8_6.

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Emtage, Spencer. "Biotechnology and Protein Production". W Delivery Systems for Peptide Drugs, 23–33. Boston, MA: Springer US, 1986. http://dx.doi.org/10.1007/978-1-4757-9960-6_2.

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Whiteley, John M. "Drug Delivery with Protein and Peptide Carriers". W Bioactive Polymeric Systems, 345–63. Boston, MA: Springer US, 1985. http://dx.doi.org/10.1007/978-1-4757-0405-1_13.

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Ding, Dan, i Xiqun Jiang. "Drug Delivery from Protein-Based Nanoparticles". W Bioinspired and Biomimetic Polymer Systems for Drug and Gene Delivery, 149–70. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2014. http://dx.doi.org/10.1002/9783527672752.ch6.

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Gabrani, Reema, Ritu Ghildiyal, Neetigyata Pratap, Garima Sharma i Shweta Dang. "Applications of Protein Nanoparticles as Drug Delivery Vehicle". W Smart Healthcare Systems, 199–215. Boca Raton : CRC Press, [2019]: Chapman and Hall/CRC, 2019. http://dx.doi.org/10.1201/9780429020575-13.

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Streszczenia konferencji na temat "Surfactant-Protein System - Drug Delivery"

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Cisek, Richard, Kennedy Brittain, MacAulay Harvey, Saranyan Pillai, Sean D. Christie i Danielle Tokarz. "Measurement of the Crystalline Structure of Collagen-Like Scaffolds of Otoconia in the Mouse Vestibular System by Second Harmonic Generation Microscopy". W Optical Molecular Probes, Imaging and Drug Delivery. Washington, D.C.: Optica Publishing Group, 2023. http://dx.doi.org/10.1364/omp.2023.om4e.1.

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Polarization-resolved second harmonic generation microscopy was used to elucidate the arrangement of SHG emitters in a collagen-like protein matrix embedded in mammalian inner ear crystals revealing a radial nano- and macro-arrangement.

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Blanco, Letia, Panos S. Shiakolas, Pranesh B. Aswath, Christopher B. Alberts, Chris Grace, Kyle Godfrey i Drew Patin. "A Thermoresponsive Hydrogel Based Controlled Drug Delivery Device". W ASME 2012 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/imece2012-88564.

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Thermoresponsive hydrogels exhibit the unique property of volume change as a function of change in temperature as they transition between hydrophilic and hydrophobic states. These hydrogels can be loaded with drug/protein and serve as reservoirs for drug/protein delivery applications. A hydrogel based device for controlled drug delivery is designed with a number of subsystems that are interfaced with LabVIEW for development of a functional device. The device was designed using analytical and finite element analysis procedures and fabricated. In this manuscript, the device design will be reviewed and discussed. A parametric study was performed to examine the device operation and performance as function of hydrogel heating/cooling temperature profiles. Subsequently, the device was employed in a series of experiments to examine the delivery of a protein as a function of thermal stimuli. The matrix used in this study was poly(ethylene glycol) diacrylate (PEGDA) and the drug delivery nanoparticles carriers were poly(N-isopropylacrylamide-co-acrylamide (PNIPAM) with a lower critical solution temperature (LCST) around 40°C. The protein of choice was bovine serum albumin (BSA). The results of this study illustrate that the development of a multi-drug or therapeutic delivery device is possible and that individual drugs can be delivered on demand using a closed loop control system.

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Zheng, Zhuoyuan, Akash Singh i Yumeng Li. "Molecular Dynamic Simulation Study on Soy Protein As Drug Delivery Vehicle". W ASME 2020 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2020. http://dx.doi.org/10.1115/imece2020-23590.

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Abstract Protein-based drug carriers are promising candidates for efficient drug delivery among the available potential colloidal carrier systems, due to their low cytotoxicity, abundance, renewability, diverse functional groups and interactions, and high drug loading capacity, etc. In this study, molecular dynamics (MD) simulations are performed to study the mechanisms of 11S molecule of soy protein as drug delivery vehicle to attach allyl isothiocyanate (AITC) and doxorubicin (DOX) drugs. The intermolecular interactions between protein and drugs are investigated; and the loading capacities of the protein molecules are calculated and compared with experiments. It is found that, for the AITC system, both nonpolar and polar residues of protein have the ability to adsorb AITCs; particularly, the polar residues serve as the primary active sites for the stable attachment of the drug molecules through the electrostatic (dipole-dipole) interactions. For the DOX system, however, the main driving force become the π-π stacking (the van der Waals interactions) among the aromatic rings of DOX and protein. In addition to pristine protein, different denaturation processes are found to be able to increase the exposure of active sites, therefore, enhance the loading efficiency of the protein carriers.

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Ratnayake, W. R. A. P. J., J. W. Damunupola, S. Rajapakse i A. C. A. Jayasundera. "Nanocellulose-Protein Matrices: A Model System for Controlled Drug Delivery". W International Conference on Nano Science and Nano Technology. The International Institute of Knowledge Management (TIIKM), 2018. http://dx.doi.org/10.17501/23861215.2018.5101.

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Hui Ma, Guang. "Particle System for Protein Drug Delivery: Strategy,Preparation and Application". W 5th Asian Particle Technology Symposium. Singapore: Research Publishing Services, 2012. http://dx.doi.org/10.3850/978-981-07-2518-1_246.

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Lopez Rodriguez, Elena, Carolin Laukamp, Lilian Steffen, Matthias Ochs i Lars Knudsen. "Pulmonary surfactant as drug delivery system to target lung epithelium: new approach for the treatment of epithelial injury after bleomycin challenge". W ERS International Congress 2018 abstracts. European Respiratory Society, 2018. http://dx.doi.org/10.1183/13993003.congress-2018.pa592.

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Quan, Glen Lelyn, Kentaro Matsumiya, Michiaki Araki, Yasuki Matsumura i Yoshihiko Hirata. "The role of sophorolipid as carrier of active substances". W 2022 AOCS Annual Meeting & Expo. American Oil Chemists' Society (AOCS), 2022. http://dx.doi.org/10.21748/hnkx3869.

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Sophorolipid is a glycolipid-type biosurfactant, produced from natural sources by fermentation with a nonpathogenic yeast Starmerella bombicola. Its structure is composed of 2 hydrophilic parts, a sophorose unit, a glucose disaccharide glycosically linked to a hydroxyl fatty acid. Its structure spontaneously forms a vesicle of about 100 nm in an aqueous solution, which is similar to that of liposomes used as drug delivery systems and transdermal absorption promoters. It can be expected to have an effect of promoting permeation of active substances such as lactoferrin. Lactoferrin is an iron-binding glycoprotein having a molecular weight of about 80 kDa, and is most abundant in breast milk in the living body. Since it is also present in amniotic fluid that protects the mother and fetus, it is important to study the physiological relationship between skin and lactoferrin. The transdermal administration of lactoferrin with sophorolipid was verified, followed by the investigation protein-surfactant interactions between bovine lactoferrin and sophorolipid. Structural changes were further observed using spectroscopic, microscopic and biochemical methods under weakly acidic and neutral pH conditions. From particle size analysis by dynamic light scattering, microscopic observation by cryo-SEM, and digestion pattern observation by enzyme treatment, it was confirmed that bovine lactoferrin and sophorolipid interact with each other to form a sheet and nanometer-sized coagulation at pH 5.0 and 7.0 forming an aggregate, which was considered to be due to the self-organizing structure characteristic of sophorolipid. It can be concluded that sophorolipid has a potential of being a transport carrier of active substances, which can have vast applications not only in cosmetics but in drug delivery systems as well. Biosurfactants and biopolymers: Between interactions, orthogonality and mutual

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Lestari, Sri Rahayu, Abdul Gofur, Fauziatul Fajaroh, Siti lmroatul Maslikah, Yuslinda Annisa i Nik Ahmad Nizam Nik Malek. "Self-nanoemulsifying drug delivery system (SNEEDS) for improved bioavailability of active compound on single clove garlic: Optimization of PEG 400 and glycerol as co-surfactant". W INTERNATIONAL CONFERENCE ON LIFE SCIENCES AND TECHNOLOGY (ICoLiST 2020). AIP Publishing, 2021. http://dx.doi.org/10.1063/5.0052638.

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Usta, Aybala, Muhammad Rahman i Ramazan Asmatulu. "Synthesis, Stability and Selection Study of Oil-in-Water Nanoemulsions Containing Nigella Sativa L. Essential Oil". W ASME 2017 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/imece2017-72205.

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Targeted drug delivery has a great importance in cancer treatment and is in interest of many scientists worldwide. Targeted drug delivery renders local treatment of cancerous cells possible without affecting healthy cells. Hydrogels are promising materials to be used in targeted drug delivery systems due to their biocompatible nature and injectable behaviors where they can be used to load drugs. However, considering that not all the drugs are water soluble, entrapment of some drugs into hydrogels is not practical in terms of poor drug solubility and burst drug release because of this. At this point, an oil phase can be considered as a drug carrying agent, and entrapment of this oil phase into hydrogel would make it possible for in-situ injection of dissolved drug in oil phase. Oil in water (O/W)-type nanoemulsions were prepared using black seed oil, which is known to cause apoptosis via p-53 dependent mechanism, water and Triton X-100, Span-80 surfactant combinations. Three different oil percentage and three different surfactant percentage were tested, and stability behaviors of nanoemulsions were investigated and compared. Dynamic light scattering analysis and zeta potential measurements were conducted for determination of particles sizes and surface charges of the nanoemulsions. The most stable nanoemulsion along with having smallest diameter and lowest polydispersity index (PDI) was used for further studies. Results indicated that using both hydrophilic and hydrophobic surfactants together increased the stability of nanoemulsions compared to those using either of them.

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Matsuoka, Eitaro, Satoshi Muto i Hirofumi Daiguji. "Fabrication of Hollow Polyelectrolyte Microcapsules From Microbubble Templates". W ASME 2009 Second International Conference on Micro/Nanoscale Heat and Mass Transfer. ASMEDC, 2009. http://dx.doi.org/10.1115/mnhmt2009-18418.

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Hollow microcapsules made of biodegradable polymers have attracted considerable attention for ultrasound contrast agents and drug delivery system. In normal fabrication techniques, stable microbubbles are formed in a surfactant solution via ultrasound, then polyelectrolyte are adsorbed on the microbubble surface, resulting in hollow microcapsules. This document proposes a new method. First, a poly-allylamine hydrochloride (PAH) polyelectrolyte aqueous solution was adjusted at pH = 12.0. Carbon dioxide (CO2) was dissolved at 300 kPa (gage) in the polyelectrolyte solution. The pH of the solution decreased with increasing dissolved CO2, and the solution became turbid at pH = 9. The solution was then degassed at 1 atm, yielding microbubbles. The polyelectrolyte was then adsorbed on the microbubble surface and became the microcapsule shell. Very smooth spherical particulates were responsible of this. These particles were microbubbles and not aggregation of polyelectrolyte molecules; however, the particles did not coalesce, nor diffused into the solution, and were more stable compared to bubbles. Fluorescent analysis revealed that these particles were polyelectrolyte adsorbed to the bubble surface. This method was successfully used to fabricate hollow PAH polyelectrolyte microcapsules from microbubble templates without surfactants.

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