Gotowe bibliografie tematyczne / Suicidal behaviour – Treatment

Gotowa bibliografia na temat „Suicidal behaviour – Treatment”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 11 lutego 2022

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Artykuły w czasopismach na temat "Suicidal behaviour – Treatment"

Wisłowska-Stanek, Aleksandra, Karolina Kołosowska i Piotr Maciejak. "Neurobiological Basis of Increased Risk for Suicidal Behaviour". Cells 10, nr 10 (23.09.2021): 2519. http://dx.doi.org/10.3390/cells10102519.

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According to the World Health Organization (WHO), more than 700,000 people die per year due to suicide. Suicide risk factors include a previous suicide attempt and psychiatric disorders. The highest mortality rate in suicide worldwide is due to depression. Current evidence suggests that suicide etiopathogenesis is associated with neuroinflammation that activates the kynurenine pathway and causes subsequent serotonin depletion and stimulation of glutamate neurotransmission. These changes are accompanied by decreased BDNF (brain-derived neurotrophic factor) levels in the brain, which is often linked to impaired neuroplasticity and cognitive deficits. Most suicidal patients have a hyperactive hypothalamus–pituitary–adrenal (HPA) axis. Epigenetic mechanisms control the above-mentioned neurobiological changes associated with suicidal behaviour. Suicide risk could be attenuated by appropriate psychological treatment, electroconvulsive treatment, and drugs: lithium, ketamine, esketamine, clozapine. In this review, we present the etiopathogenesis of suicide behaviour and explore the mechanisms of action of anti-suicidal treatments, pinpointing similarities among them.

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Aquin, Joshua P., Leslie E. Roos, Jino Distasio, Laurence Y. Katz, Jimmy Bourque, James M. Bolton, Shay-Lee Bolton i in. "Effect of Housing First on Suicidal Behaviour". Canadian Journal of Psychiatry 62, nr 7 (27.02.2017): 473–81. http://dx.doi.org/10.1177/0706743717694836.

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Objective: This study attempted to determine if Housing First (HF) decreased suicidal ideation and attempts compared to treatment as usual (TAU) amongst homeless persons with mental disorders, a population with a demonstrably high risk of suicidal behaviour. Method: The At Home/Chez Soi project is an unblinded, randomised control trial conducted across 5 Canadian cities (Vancouver, Winnipeg, Toronto, Montreal, Moncton) from 2009 to 2013. Homeless adults with a diagnosed major mental health disorder were recruited through community agencies and randomised to HF ( n = 1265) and TAU ( n = 990). HF participants were provided with private housing units and received case management support services. TAU participants retained access to existing community supports. Past-month suicidal ideation was measured at baseline and 6, 12, 18, and 21/24 months. A history of suicide attempts was measured at baseline and the 21/24-month follow-up. Results: Compared to baseline, there was an overall trend of decreased past-month suicidal ideation (estimate = –.57, SE = .05, P < 0.001), with no effect of treatment group (i.e., HF vs. TAU; estimate = –.04, SE = .06, P = 0.51). Furthermore, there was no effect of treatment status (estimate = –.10, SE = .16, P = 0.52) on prevalence of suicide attempts (HF = 11.9%, TAU = 10.5%) during the 2-year follow-up period. Conclusion: This study failed to find evidence that HF is superior to TAU in reducing suicidal ideation and attempts. We suggest that HF interventions consider supplemental psychological treatments that have proven efficacy in reducing suicidal behaviour. It remains to be determined what kind of suicide prevention interventions (if any) are specifically effective in further reducing suicidal risk in a housing-first intervention.

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Suherman, Suherman. "INITIAL STUDY OF LINGUISTIC; VERBAL AND NONVERBAL SIGN OF ATTEMPTED SUICIDE AMONG ADOLESCENTS". Elevate The International Journal of Nursing Education, Practice and Research 1, nr 1 (24.07.2018): 29–32. http://dx.doi.org/10.25077/elevate.1.1.29-32.2018.

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Increasing number of suicide cases, especially in adolescents, becomes problems that require serious treatment. Adolescence is a period of transition and hormonal development that can affect the emotions or mood. It is known that before attempting suicide, there are signs of language or linguistic such as verbal and nonverbal as an indication of the suicidal behavior action. This systematic review aims to identify these signs based on the results of several studies. There were 12 articles that have reviewed, the results showed there are three aspect that can be identified: used language from the suicider; perception of suicider toward the behaviour; and observerd behaviours. Most of the suicider express the feeling of Hopeless, Self-balming, feeling depressed and lonely, and also withdraw from society. It is expectedthat the result can be used as basic data toindentify signs and symptoms of suicide in adolescents. Keywords: observed behaviors, suicide language; emotional expression

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Bertelsen, Mette, Pia Jeppesen, Lone Petersen, Anne Thorup, Johan ⊘hlenschlæger, Phuong Le Quach, Torben Østergaard Christensen, Gertrud Krarup, Per J⊘rgensen i Merete Nordentoft. "Suicidal behaviour and mortality in first-episode psychosis: the OPUS trial". British Journal of Psychiatry 191, S51 (grudzień 2007): s140—s146. http://dx.doi.org/10.1192/bjp.191.51.s140.

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BackgroundThose with first-episode psychosis are at high-risk of suicideAimsTo identify predictive factors for suicidal thoughts, plans and attempts, and to investigate the rate of suicides and other deaths during the 5 years after first diagnosis and initiation of treatmentMethodA longitudinal, prospective, 5-year follow-up study of 547 individuals with first-episode schizophrenia spectrum psychosis. Individuals presenting for their first treatment in mental health services in two circumscribed urban areas in Denmark were included in a randomised controlled trial of integrated v. standard treatment. All participants were followed in the Danish Cause of Death Register for 5 years. Suicidal behaviour and clinical and social status were assessed using validated interviews and rating scales at entry, and at 1- and 2-year follow-upsResultsSixteen participants died during the follow-up. We found a strong association between suicidal thoughts, plans and previous attempts, depressive and psychotic symptoms and young age, and with suicidal plans and attempts at 1- and 2-year follow-upConclusionsIn this first-episode cohort depressive and psychotic symptoms, especially hallucinations, predicted suicidal plans and attempts, and persistent suicidal behaviour and ideation were associated with high risk of attempted suicide

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VUORILEHTO, M. S., T. K. MELARTIN i E. T. ISOMETSÄ. "Suicidal behaviour among primary-care patients with depressive disorders". Psychological Medicine 36, nr 2 (23.11.2005): 203–10. http://dx.doi.org/10.1017/s0033291705006550.

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Background. Most national suicide prevention strategies set improved detection and management of depression in primary health care into a central position. However, suicidal behaviour among primary-care patients with depressive disorders has been seldom investigated.Method. In the Vantaa Primary Care Depression Study, a total of 1119 primary-care patients in the City of Vantaa, Finland, aged 20 to 69 years, were screened for depression with the Primary Care Evaluation of Mental Disorders (PRIME-MD) questionnaire. Depressive disorders were diagnosed with the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I), and the 137 patients with depressive disorder were included in the study. Suicidal behaviour was investigated cross-sectionally and retrospectively in three time-frames: current, current depressive episode, and lifetime. Current suicidal ideation was measured with the Scale for Suicidal Ideation (SSI), and previous ideation and suicide attempts were evaluated based on interviews plus medical and psychiatric records.Results. Within their lifetimes, 37% (51/137) of the patients had seriously considered suicide and 17% (23/137) attempted it. Lifetime suicidal behaviour was independently and strongly predicted by psychiatric treatment history and co-morbid personality disorder, and suicidal behaviour within the current episode was predicted most effectively by severity of depression.Conclusions. Based on these findings and their convergence with studies of completed suicides, prevention of suicidal behaviour in primary care should probably focus more on high-risk subgroups of depressed patients, including those with moderate to severe major depressive disorder, personality disorder or a history of psychiatric care. Recognition of suicidal behaviour should be improved. The complex psychopathology of these patients in primary care needs to be considered in targeting preventive efforts.

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Walsh, Elizabeth, Kate Harvey, Ian White, Anna Higgitt, Janelle Fraser i Robin Murray. "Suicidal behaviour in psychosis: Prevalence and predictors from a randomised controlled trial of case management". British Journal of Psychiatry 178, nr 3 (marzec 2001): 255–60. http://dx.doi.org/10.1192/bjp.178.3.255.

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BackgroundIt is unclear whether intensive case management influences the prevalence of suicidal behaviour in patients with psychosis.AimsTo compare the effect of intensive case management and standard care on prevalence of suicidal behaviour in patients with chronic psychosis.MethodPatients with established psychosis (n=708) were randomised either to intensive case management or to standard care. The prevalence of suicidal behaviour was estimated at 2-year follow-up and compared between treatment groups. Suicide attempters and non-attempters were compared on multiple socio-demographic and clinical variables to identify predictors of suicidal behaviour.ResultsThere was no significant difference in prevalence of suicidal behaviour between treatment groups. Recent attempts at suicide and multiple recent hospital admissions best predicted future attempts.ConclusionsIntensive case management does not appear to influence the prevalence of suicidal behaviour in chronic psychosis. Predictors identified in this study confirm some previous findings.

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Özlü-Erkilic, Zeliha, Thomas Wenzel, Oswald D. Kothgassner i Türkan Akkaya-Kalayci. "Transcultural Differences in Risk Factors and in Triggering Reasons of Suicidal and Self-Harming Behaviour in Young People with and without a Migration Background". International Journal of Environmental Research and Public Health 17, nr 18 (7.09.2020): 6498. http://dx.doi.org/10.3390/ijerph17186498.

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Minors with and without migration background can have different risk factors and triggering reasons for self-harming and suicidal behaviour. We retrospectively analysed the data of 192 children and adolescents to investigate the transcultural differences in self-harming, as well as suicidal behaviour in Austrian, Turkish, and Bosnian/Croatian/Serbian (BCS)-speaking patients, who were treated in an emergency out-patient clinic in Vienna. Our results showed transcultural differences in both behaviours. In all groups, females had higher rates of suicide attempts and self-harming behaviour than males. While Turkish-speaking patients received treatment more often, after attempted suicide, Austrians and BCS-speaking patients needed treatment more often for acute stress disorder. Suicide attempts and self-harming behaviours were triggered most frequently by intrafamilial problems, but more frequently in migrant patients. Turkish-speaking patients were at a more than 2 times (OR = 2.21, 95%CI: 1.408–3.477) higher risk for suicide attempts, and were triggered almost 3 times (OR = 2.94, 95%CI: 1.632–5.304) more often by interfamilial conflicts. The suicide attempts of BCS-speaking minors were more often caused by relationship and separation crises (OR = 2.56, 95%CI: 1.148–5.705). These transcultural differences in suicidal and self-harming behaviour of minors, demand an increase of transcultural competence to provide optimal treatment of migrant children.

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Beautrais, Annette L. "Risk Factors for Suicide and Attempted Suicide among Young People". Australian & New Zealand Journal of Psychiatry 34, nr 3 (czerwiec 2000): 420–36. http://dx.doi.org/10.1080/j.1440-1614.2000.00691.x.

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Objective: Suicide rates in young people have increased during the past three decades, particularly among young males, and there is increasing public and policy concern about the issue of youth suicide in Australia and New Zealand. This paper summarises current knowledge about risk factors for suicide and suicide attempts in young people. Method: Evidence about risk factors for suicidal behaviour in young people was gathered by review of relevant English language articles and other papers, published since the mid-1980s. Results: The international literature yields a generally consistent account of the risk factors and life processes that lead to youth suicide and suicide attempts. Risk factor domains which may contribute to suicidal behaviour include: social and educational disadvantage; childhood and family adversity; psychopathology; individual and personal vulnerabilities; exposure to stressful life events and circumstances; and social, cultural and contextual factors. Frequently, suicidal behaviours in young people appear to be a consequence of adverse life sequences in which multiple risk factors from these domains combine to increase risk of suicidal behaviour. Conclusions: Current research evidence suggests that the strongest risk factors for youth suicide are mental disorders (in particular, affective disorders, substance use disorders and antisocial behaviours) and a history of psychopathology, indicating that priorities for intervening to reduce youth suicidal behaviours lie with interventions focused upon the improved recognition, treatment and management of young people with mental disorders.

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Nordentoft, M., P. Jeppesen, M. Abel, P. Kassow, L. Petersen, A. Thorup, G. Krarup, R. Hemmingsen i P. Jørgensen. "OPUS study: Suicidal behaviour, suicidal ideation and hopelessness among patients with first-episode psychosis". British Journal of Psychiatry 181, S43 (wrzesień 2002): s98—s106. http://dx.doi.org/10.1192/bjp.181.43.s98.

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BackgroundPatients with first-episode psychosis comprise a high-risk group in terms of suicide.AimsTo identify predictive factors for suicidal behaviour and to examine the effect of integrated treatment on suicidal behaviour and hopelessness.MethodA total of 341 patients with a first-episode schizophrenia-spectrum disorder were randomised to integrated treatment or treatment as usual.ResultsDuring the 1-year follow-up period, 11% attempted suicide. This was associated with female gender, hopelessness, hallucinations and suicide attempt reported at baseline, with the two latter variables being the only significant ones in the final multivariate model. The integrated treatment reduced hopelessness.ConclusionsHallucinations and suicide attempt before inclusion in the study were the most significant predictors of suicide attempt in the follow-up period.

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Mehlum, Lars. "Clinical challenges in the assessment and management of suicidal behaviour in patients with bordeline personality disorder". Epidemiologia e Psichiatria Sociale 18, nr 3 (wrzesień 2009): 184–90. http://dx.doi.org/10.1017/s1121189x00000440.

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AbstractSelf-injurious and suicidal behaviours are highly prevalent in patients with borderline personality disorder (BPD) and the risk of completed suicide is high. Borderline patients often present with heterogeneous clinical pictures and widespread comor-bidity complicating clinical assessments and management. This calls for increased efforts in systematic evaluation and monitoring of self-harming and suicidal behaviours; these behaviours should be addressed actively as high priority treatment targets. Early drop-out is common for BPD patients in treatment but is possible to counteract by fostering a strong therapeutic relationship through adopting a realistic, but consistent and supportive approach carefully avoiding reinforcement of suicidal behaviours. Suicidal crises should primarily be managed in an outpatient setting giving priority to keeping the patient safe adopting a safety plan procedure, while helping the patient as quickly as possible to return emotionally to a more acceptable level of arousal and mental functioning. Pharmacological treatments should primarily be used for management of comorbid conditions, but may possibly also be helpful when used to reduce specific symptoms such as anger, hostility and impulsivity. There is currently a range of different integrated short-term and long-term psychological treatments in different stages of development and some of them have been shown to be efficacious in reducing suicidal behaviours; notably dialectical behaviour therapy and mentalization-based therapy.Declaration of Interest: None.

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Rozprawy doktorskie na temat "Suicidal behaviour – Treatment"

Idenfors, Hans. "Young people's contact with healthcare before and after suicidal behaviour". Doctoral thesis, Umeå universitet, Psykiatri, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-120699.

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Background Self-harm is a major and growing public health issue among young people worldwide. Self-harm is an important risk factor for suicide, which is one of the leading causes of death for young people. Although suicide rates are declining overall, this trend is not seen in young people. Young people with mental distress and/or suicidal thoughts are reluctant to seek help, and often drop out of treatment initiated after a self-harm episode. Many young people who self-harm have had contact with healthcare before their first self-harm episode, but often for reasons other than suicidal thoughts or psychiatric problems. In this context, physical illness is associated with increased risk for self-harm and suicide among young people. The present thesis investigated how young people perceived the help and support they received before and after an episode of self-harm. A further aim was to map the inpatient somatic healthcare contacts young patients had before an episode of self-harm, and determine any relationship to risk for self-harm and suicide. Method Four studies were conducted using qualitative and quantitative methods. Participants were people aged 16-24 years. The definition of self-harm was based on the intentional self-harm criteria in the International Classification of Diseases, tenth revision, which includes all forms of self-harm without ascribing suicidal intent. In the first two studies, 10 respective 9 participants with a first healthcare contact for self-harm were interviewed during 2009-2011. The interviews covered participants’ knowledge and experience of professional care before their healthcare contact for self-harm. Participants were interviewed a second time 6 months later about their experiences with professional care during the period since their initial interview. Qualitative content analysis was used for all interviews. For the next two studies, we selected 16,235 participants with a first hospitalisation for self-harm during 1999-2009 from the Swedish National Inpatient Register. These cases were compared with matched controls to determine the odds of having been admitted with a non-psychiatric diagnosis during the year preceding the self-harm admission. To assess risk for suicide, data were retrieved from the Swedish Cause of Death Register for all deceased participants until 2013, and group differences were determined using survival analysis. Results In the first interview, participants described how they wanted more information on where they could turn for professional help. They also wanted different help-seeking pathways and emphasised the importance of the quality of professional contact. After 6 months, participants stressed the importance of being able to rely on professionals and treatment. Their life circumstances significantly affected their treatment, and practical help was appreciated. The register studies showed that young people admitted for self-harm were more likely to have been hospitalised with symptomatic diagnoses such as abdominal pain and syncope/collapse, and somatic illnesses such as epilepsy and diabetes mellitus type 1. A higher proportion of cases (4.5%; women 2.6%, men 8.8%) died during the study period than controls (0.3%; women 0.2%, men 0.6%) (p<0.001). For both cases and controls, a higher proportion of those with a previous somatic admission died from suicide during the study period than those without a somatic admission (cases: 4.2% vs. 2.8%, p<0.05). For cases with a somatic admission, the hazard ratio was 1.43 (95% confidence interval 1.04-1.98) compared with those without somatic admissions (controlled for age, sex and psychiatric admission). Survival of cases with a previous somatic admission compared with those without was 98.4% versus 99.2% after the first year, 97.8% versus 98.9% after the second year, and 95.5% versus 96.9% after the tenth year. Conclusion These findings suggest that healthcare providers need to find new ways to reach young people at risk for suicidal behaviour. Access to professional help should be easy and direct. Treatment for young people after self-harm should be flexible, and be receptive to input from the patient. The importance of and need for basic practical help should not be overlooked. Somatic healthcare contact provides an opportunity for intervention, particularly as psychiatric problems can manifest as physical symptoms, and physical illness is a risk factor for self-harm and suicide.

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Edwards, Stephen J. "No-suicide contracts, no-suicide agreements and no-suicide assurances : an exploratory study of their nature, utilization and perceived effectiveness". University of Western Australia. Social Work and Social Policy Discipline Group, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0149.

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The research examined mental health practitioners' attitudes towards, satisfaction with and use of suicide prevention contracting (SPC) techniques. Survey respondents comprised consultant psychiatrists, clinical psychologists, occupational therapists, mental health nurses, psychologists, registered medical officers and social workers. A self-report questionnaire was mailed to 1347 potential respondents, together with three follow-up letters sent out at two-week intervals. There was a 31% response rate, producing 420 valid questionnaires. The results of the research re-confirm the historical trajectory of SPC, from its early beginnings as a relationship-based suicide-risk assessment technique to one that is used in contemporary practice by practitioners to meet a range of objectives. The research focused on three SPC techniques in operation in clinical practice: verbal no-suicide assurances, no-suicide agreements, and written no-suicide contracts. Analysis of the data suggests a number of important findings. The first of these is that practitioners perceive different utility among these three techniques. Secondly, the least experienced practitioners were significantly less likely to use no-suicide contracts, despite seeing more suicidality and having more formal training in the use of the technique. Thirdly, a practitioner's gender, and formal training were significant in the perception and application of SPC techniques. Finally, suicidal behaviours and completed suicide was a clinical outcome in some situations irrespective of the use and non-use of SPC. The findings of this research are used to provide an emerging conceptual framework and associated nomenclature that inform clinical decision-making in relation to SPC. In addition, a conceptual model is presented which demonstrates that the potential for injudicious use of SPC techniques is as much precipitated by individual factors as it is by broader environmental factors. Key words: no-suicide contracts, suicide prevention contracts, no-suicide agreements, no-suicide decisions, contingency contracting.

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McCulloch, Ariana, i University of Lethbridge Faculty of Education. "Psychopathological correlates of risk for adolescents in secure treatment". Thesis, Lethbridge, Alta. : University of Lethbridge, Faculty of Education, 2005, 2005. http://hdl.handle.net/10133/228.

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This research utilized data concerning adolescents at imminent risk for harm confined to the Edmonton and Lethbridge secure treatment centres in Alberta. Once screened for inclusion criteria in a single stage, non-random convenience sampling protocol, 210 files were included in the study. From these files, the adolescents' psychopathological diagnoses, Suicide Probability Scale (SPS) scores as well as other demographic data (including age, gender, ethnicity and previous suicide attempts) were recorded. This research was designed to delineate the characteristics of adolescents admitted to secure treatment, examine the overall suicide risk in this sample, investigate the relationship between study variables via crosstabulation and chi-square analysis, and to determine which independent variable/s best predicted suicide risk via ANOVA and multiple lineear regression analysis. Analysis results indicated that the sample was predominantly comprised of female adolescents, Caucasian ethnicity and was aged between 13 and 15 years. The majority of adolescents with suicide history information available in their file had previously attempted suicide. Youth demonstrated an average of 2.7 psychopathological diagnoses, the most frequent of which were conduct disorder, substance abuse, depression, adjustment disorder and parent child relational disorder. The majority of youth were in the moderate suicide risk category from SPS scores. Multiple linear regression analysis determined that the diagnoses of adjustment disorder and depression were found to be predictive of increased suicide risk scores, as was gender (females had higher risk scores), age (younger adolescents had higher risk scores) and previous suicide attempts. Those in the "other" ethnicity category demonstrated lower suicide risk scores.
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Lerner, Miriam Suzanne. "Treatment of suicide ideators: a problem-solving approach". Diss., Virginia Polytechnic Institute and State University, 1989. http://hdl.handle.net/10919/54386.

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The present study compares two types of treatments designed to reduce suicidal ideations: social problem-solving therapy and supportive therapy. Social problem-solving therapy is based on research indicating that suicidal individuals have deficits in problem-solving skills in general and in interpersonal problem-solving skills, in particular. Supportive therapy was chosen as a comparative treatment to control for nonspecific effects of problem-solving therapy and to provide an ethical alternative treatment. The results indicated that problem-solving therapy was more effective than supportive therapy for reducing depression and for improving interpersonal problem-solving self-efficacy at posttest. At 3 month follow-up there continued to be differences between the groups in depression, but not in problem-solving self-efficacy. In addition, at follow-up problem-solving therapy was more effective than supportive therapy for reducing hopelessness and loneliness. Although there were no differences between the groups on severity of suicidal ideations, within group analyses revealed that problem-solving therapy significantly reduced severity of ideations over time. The findings suggest that social problem-solving therapy is a more effective treatment than supportive therapy for reducing depression, hopelessness, and loneliness of suicidal individuals. This may be due to social problem-solving deficits being a key problem for suicidal individuals. Although there are several limitations to the study, such as small sample sizes, it provides an example of treatment research with suicidal individuals. Similar studies would be useful to further evaluate empirically-based treatments for suicidal individuals.
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Schulze, Thomas G., Martin Alda, Mazda Adli, Nirmala Akula, Raffaella Ardau, Elise T. Bui, Caterina Chillotti i in. "The International Consortium on Lithium Genetics (ConLiGen): An Initiative by the NIMH and IGSLI to Study the Genetic Basis of Response to Lithium Treatment". Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-134635.

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For more than half a decade, lithium has been successfully used to treat bipolar disorder. Worldwide, it is considered the first-line mood stabilizer. Apart from its proven antimanic and prophylactic effects, considerable evidence also suggests an antisuicidal effect in affective disorders. Lithium is also effectively used to augment antidepressant drugs in the treatment of refractory major depressive episodes and prevent relapses in recurrent unipolar depression. In contrast to many psychiatric drugs, lithium has outlasted various pharmacotherapeutic ‘fashions’, and remains an indispensable element in contemporary psychopharmacology. Nevertheless, data from pharmacogenetic studies of lithium are comparatively sparse, and these studies are generally characterized by small sample sizes and varying definitions of response. Here, we present an international effort to elucidate the genetic underpinnings of lithium response in bipolar disorder. Following an initiative by the International Group for the Study of Lithium-Treated Patients (www.IGSLI.org) and the Unit on the Genetic Basis of Mood and Anxiety Disorders at the National Institute of Mental Health,lithium researchers from around the world have formed the Consortium on Lithium Genetics (www.ConLiGen.org) to establish the largest sample to date for genome-wide studies of lithium response in bipolar disorder, currently comprising more than 1,200 patients characterized for response to lithium treatment. A stringent phenotype definition of response is one of the hallmarks of this collaboration. ConLiGen invites all lithium researchers to join its efforts
Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich

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Schulze, Thomas G., Martin Alda, Mazda Adli, Nirmala Akula, Raffaella Ardau, Elise T. Bui, Caterina Chillotti i in. "The International Consortium on Lithium Genetics (ConLiGen): An Initiative by the NIMH and IGSLI to Study the Genetic Basis of Response to Lithium Treatment". Karger, 2010. https://tud.qucosa.de/id/qucosa%3A27583.

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For more than half a decade, lithium has been successfully used to treat bipolar disorder. Worldwide, it is considered the first-line mood stabilizer. Apart from its proven antimanic and prophylactic effects, considerable evidence also suggests an antisuicidal effect in affective disorders. Lithium is also effectively used to augment antidepressant drugs in the treatment of refractory major depressive episodes and prevent relapses in recurrent unipolar depression. In contrast to many psychiatric drugs, lithium has outlasted various pharmacotherapeutic ‘fashions’, and remains an indispensable element in contemporary psychopharmacology. Nevertheless, data from pharmacogenetic studies of lithium are comparatively sparse, and these studies are generally characterized by small sample sizes and varying definitions of response. Here, we present an international effort to elucidate the genetic underpinnings of lithium response in bipolar disorder. Following an initiative by the International Group for the Study of Lithium-Treated Patients (www.IGSLI.org) and the Unit on the Genetic Basis of Mood and Anxiety Disorders at the National Institute of Mental Health,lithium researchers from around the world have formed the Consortium on Lithium Genetics (www.ConLiGen.org) to establish the largest sample to date for genome-wide studies of lithium response in bipolar disorder, currently comprising more than 1,200 patients characterized for response to lithium treatment. A stringent phenotype definition of response is one of the hallmarks of this collaboration. ConLiGen invites all lithium researchers to join its efforts.
Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.

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Bartlett, Mary L. Carney Jamie S. "The efficacy of no-suicide contracts with clients in counseling on an outpatient basis". Auburn, Ala., 2006. http://repo.lib.auburn.edu/2006%20Summer/Dissertations/BARTLETT_MARY_51.pdf.

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Swanston, Heather Yvette. "Five Years After Child Sexual Abuse". University of Sydney. Paediatrics and Child Health, 2000. http://hdl.handle.net/2123/573.

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Introduction Child sexual abuse is a common problem. Psychological and behavioural problems in children and adults who have experienced child sexual abuse have been associated with the abuse. Little research has been conducted which has been long-term, prospective, involved substantiated sexual abuse, included a control group, took into account mediating factors, utilised multiple data sources, relied on standardised measures and had a high follow-up rate. Aim The aims of this study were to compare a cohort of sexually abused young people with a group of nonabused peers and to establish predictors of psychological and behavioural outcome. Method This study was a follow-up which was long-term, prospective, involved a sample of children with substantiated sexual abuse, included a control group, took into account mediating factors, utilised multiple data sources, relied on standardised measures and had a high follow-up rate. Eighty-four sexually abused young people were followed up five years after presenting to Children�s Hospitals� Child Protection Units for sexual abuse and were compared to a group of 84 nonabused young people of similar age and sex. The two groups were compared on the basis of demographic variables, family functioning, mother�s mental health and life events; the outcome measures of depression, self-esteem, anxiety, behaviour, criminal activity, alcohol and other drug use, eating problems, running away, suicide attempts, self-injury, hopefulness, despair and attributional style; and potential mediating factors such as further notifications to the Department of Community Services, receipt of psychological treatment, legal action against offenders and victims compensation. Potential predictors of outcome were (1) demographic variables, (2) sexual abuse characteristcs, (3) intake data and (4) five year follow-up variables. Main findings Follow-up rates were 81percent (n equals 68) for cases and 89percent (n equals 75) for controls. Five years after presenting for the sexual abuse, the sexually abused young people were performing more poorly than their nonabused peers on various measures of psychological state and behaviour. Although the abused children had experienced more negative life events (p<.001), were from lower socio-economic groups (p<.0001), had more changes in parent figures (p<.001) and had mothers who were more psychologically distressed (p equals .03), multiple regression analysis showed that after allowing for these and other demographic and family factors, there were still significant differences between the groups after the 5 years. The abused children displayed more disturbed behavior (p equals .002), had lower self-esteem (p<.001), were more depressed or unhappy (p<.001) and were more anxious (p equals .03) than controls. Sexually abused children had significantly higher levels of bingeing (p equals .02), self-injury (p equals.009) and suicide attempts (p equals .03). Significant predictors of psychological and behavioural outcome were significantly related to family and parent functioning variables. Abuse status was not a significant predictor when offered to each of the predictive models. Significant predictors of outcome included the following intake variables: family functioning, mother�s mental health, whether parents were employed or not, behaviour scores, prior notifications for neglect, history of parental discord and whether there were caregiver changes or not prior to intake. The classification of the index sexual abuse event as indecent assault and whether there were notifications for sexual abuse prior to the index event also significantly predicted outcome. Five year follow-up variables which were significant predictors of outcome were the young person�s age, number of negative life events, attributional style, self-esteem, depression, number of parent changes, anxiety, despair, whether there were notifications for abuse/neglect after intake and having a parent with a history of drug/alcohol problems. Conclusions Difficulties associated with child sexual abuse continue for some years after the abuse event. Child sexual abuse needs to be considered as a possible antecedent of behaviour and psychological difficulties in young people. Treatment and monitoring should continue for some years after the abuse. Treatment may need to be directed more towards young people�s psychological states rather than focusing specifically on the sexual abuse. Family and parent functioning may need to be addressed early in order to prevent some of the behavioural and psychological difficulties associated with the long-term outcome of child sexual abuse.

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Sarkohi, Ali. "Future Thinking and Depression". Doctoral thesis, Linköpings universitet, Institutet för handikappvetenskap (IHV), 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-72214.

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The ability to imagine negative or positive future events is associated with psychological well-being. The present thesis deals with depressed individual’s ability to imagine negative or positive future events. It consists of three quantitative studies (I-III) and one qualitative study (IV). Participants in studies I-III were assessed in connection with a randomized controlled trial of two ways to deliver Internet-based treatment for major depressive disorder (MDD). Their ages ranged between 19-65 years. In addition to receiving treatment participants completed the Controlled Word Association Test; the Autobiographical Memory test (AMT) and the Future Thinking Task (FTT). Participants in study IV were recruited from a psychiatric clinic in Sweden. The sample sizes varied between study I (N=40), II (N=88), III (N=47) and IV (N=15). The aim of the first study was to compare positive and negative future thinking in a group of depressed individuals (n=20) who were compared with a matched group of non-depressed persons (n=20). The results showed that depressed persons report lower scores regarding anticipated future positive events, but that they do not differ in terms of future negative events. The aim of the second study was to examine the association between FTT and AMT in a depressed sample. The results showed that positive future thinking was significantly correlated with retrieval of specific positive autobiographical memories (r = 0.23). The results only gave weak support for an association between FTT and AMT. The aim of the third study was to investigate if scores on the FTT would change following two forms of Internet-delivered cognitive behaviour therapy for major depression (guided self-help and e-mail therapy). A second aim was to study if changes in depression scores as measured by the Beck Depression Inventory would correlate with changes in future thinking. The results showed that FTT index scores for negative events were reduced after treatment. There was no increase for the positive events. Change scores for the FTT negative events and depression symptoms were significantly correlated. The aim of the fourth study was to investigate representations of the future in depressed individuals by using open-ended methodology inspired by grounded theory. The results showed that depressed individuals experienced a state of “ambivalence”. Ambivalence and its negative emotional and cognitive effects were substantially reduced in strength when participants were asked about their distant future. The conclusions drawn from these studies are that depressed persons report lower scores regarding anticipated future positive events (Study I). There is some support for a positive association between FTT and AMT, but the association is weak and only concern positive FTT and positive AMT (Study II). Negative future thinking may be reduced after Internet-delivered treatment, and changes in depressive symptoms correlate to some extent with reductions in negative future thinking (Study III). The concept of ambivalence may be an important feature of depression which deserves more attention from both a theoretical and clinical perspective (Study VI).
Förmågan att föreställa sig negativa eller positiva framtida händelser är förknippad med vårt psykiska välbefinnande. Denna avhandling fokuserar deprimerade individers förmåga att föreställa sig negativa eller positiva framtida händelser. Den består av tre kvantitativa studier (I-III) och en kvalitativ studie (IV). Deltagare i studie I-III rekryterades i samband med en randomiserad kontrollerad studie av två sätt att ge Internet-baserad behandling för egentlig depression (vägledd självhjälp och e-postterapi) . Deltagarnas ålder varierade mellan 19-65 år. Förutom att gå igenom behandling fick deltagarna genomföra olika tester ( Controlled Word Association Test (COWAT), Autobiographical Memory test (AMT) och Future Thinking Task (FTT)). Deltagarna i studie IV rekryterades från en vuxenpsykiatrisk klinik i Sverige. Sampelstorleken varierade mellan studie I (n = 40), II (n = 88), III (n = 47) och IV (n = 15). Syftet med den första studien var att undersöka positiva och negativa framtidstankar hos deprimerade individer (n = 20) vilka jämfördes med en matchad grupp av icke-deprimerade individer (n = 20). Resultaten visade att deprimerade individer rapporterade färre förväntade framtida positiva händelser, men att de inte skiljer sig åt vad gäller framtida negativa händelser. Syftet med den andra studien var att undersöka sambandet mellan FTT och AMT hos deprimerade individer. Resultaten visade att positivt framtidstänkande var signifikant korrelerat med specifika positiva självbiografiska minnen (r = 0.23). Dock visade resultaten enbart ett svagt stöd för ett statistiskt signifikant samband mellan FTT och AMT. Syftet med den tredje studien var att undersöka om poäng på FTT ändrades som en följd av två former av Internetbaserad kognitiv beteendeterapi hos deprimerade individer. Ett andra syfte var att studera om förändringar i depressionspoäng mätt med Beck Depression Inventory skulle korrelera med förändringar i FTT. Resultaten visade att FTT indexpoäng för negativa händelser minskade efter behandling. Det fanns ingen ökning gällande positiva händelser. Ändrade poäng för FTT negativa händelser och depressionssymtom var signifikant korrelerade. Syftet med den fjärde studien var att undersöka representationer av framtiden hos deprimerade individer genom att använda en ”open-ended” metodik inspirerad av grundad teori. Resultaten visade att deprimerade individer upplevde ett tillstånd av "ambivalens". Ambivalensen och dess negativa emotionella och kognitiva effekter minskade betydligt i styrka när de tillfrågades om en mer avlägsen framtid. Slutsatserna från dessa studier är att deprimerade individer rapporter färre förväntade framtida positiva händelser, men att de inte skiljer sig från en kontrollgrupp avseende antal negativa framtida händelser (Studie I). Det finns visst stöd för ett positivt samband mellan FTT och AMT, men sambandet är svag och avser endast positiva FTT och positiva AMT (Studie II). Negativt framtidstänkande kan reduceras efter Internetbaserad behandling, och förändringar i depressionssymtom korrelerar till viss del med minskning av negativt framtidstänkande (studie III). Koncepten ambivalens vid depression kan vara ett viktigt inslag av depression som förtjänar mer uppmärksamhet från både ett teoretiskt och kliniskt perspektiv (Studie VI).

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Hoertel, Nicolas. "Effets des pathologies psychiatriques sur le risque de tentative de suicide : similitudes et différences selon l’âge au sein d’une cohorte en population générale Mental disorders and risk of suicide attempt: a national prospective study A dimensional liability model of age differences in mental disorder prevalence: evidence from a national sample Effects of psychiatric disorders on suicide attempt: similarities and differences between older and younger adults in a national cohort study A comprehensive model of predictors of suicide attempt in depressed individuals and effect of treatment-seeking behavior: results from a national 3-year prospective study". Thesis, Sorbonne Paris Cité, 2018. http://www.theses.fr/2018USPCB007.

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Les troubles mentaux sont associés à un risque accru de tentative de suicide. Or, la comorbidité entre les troubles psychiatriques est fréquente et peut être expliquée par des modèles où ces troubles sont appréhendés comme des manifestations de dimensions latentes de psychopathologie. Nous avons cherché à évaluer si le risque de tentative de suicide est dû à certains troubles psychiatriques ou à certaines dimensions de psychopathologie (internalisée ou externalisée) ou à un facteur de psychopathologie générale. Au sein d’une cohorte en population générale suivie sur une période de trois ans, nous avons utilisé des modèles d’équation structurelle afin de distinguer les effets spécifiques des effets partagés des différents troubles mentaux sur le risque de tentative de suicide. La structure dimensionnelle globale des troubles psychiatriques était invariante selon l'âge et leurs effets sur le risque de tentative de suicide étaient médiés principalement par une dimension de psychopathologie générale représentant un effet commun partagé, quel que soit le groupe d'âge. Cet effet était significativement plus faible chez les adultes d’au moins 50 ans comparativement aux sujets les plus jeunes. Les résultats étaient similaires en utilisant différentes approches de modélisation de la comorbidité psychiatrique, ainsi que dans un modèle incluant la plupart des facteurs de risque cliniques de tentative de suicide dans le sous-groupe de sujets présentant un épisode dépressif caractérisé. Nos résultats suggèrent que le facteur de psychopathologie générale a un rôle majeur et devrait être considéré comme une cible thérapeutique privilégiée afin de permettre une meilleure prévention du suicide
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Książki na temat "Suicidal behaviour – Treatment"

McLaughlin, Columba. Suicide-related behaviour: Understanding, caring, and therapeutic responses. Chichester: John Wiley & Sons, 2007.

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Suicidal behavior. Cambridge, MA: Hogrefe, 2009.

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Suicide and the inner voice: Risk assessment, treatment, and case management. Thousand Oaks, Calif: Sage Publications, 1997.

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Illinois. Department of Public Health. 2007 Illinois suicide prevention strategic plan. [Springfield, Ill.]: Illinois Dept. of Public Health, 2008.

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Arthur, Freeman. Cognitive therapy of suicidal behavior: Manual for treatment. New York: Springer Pub. Co., 1993.

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Lavigne, Jill E. Frontiers in suicide risk: Research, treatment, and prevention. Hauppauge, N.Y: Nova Science Publishers, 2011.

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Leo, Diego De. International suicide rates and prevention strategies. Gottingen: Hogrefe & Huber, 2004.

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Russell, Evans, red. International suicide rates and prevention strategies. Cambridge, MA: Hogrefe & Huber, 2004.

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A, Reinecke Mark, red. Cognitive therapy of suicidal behavior: A manual for treatment. New York: Springer Pub. Co., 1993.

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Robin, Gearing, red. Suicide assessment and treatment: Empirical and evidence-based practices. New York: Springer Pub., 2010.

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Części książek na temat "Suicidal behaviour – Treatment"

Bell, Lorraine. "Agreeing a treatment plan or SFI". W Helping People Overcome Suicidal Thoughts, Urges and Behaviour, 104. Abingdon, Oxon; New York, NY: Routledge, 2021.: Routledge, 2021. http://dx.doi.org/10.4324/9781003098805-18.

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Freeman, Arthur, James Pretzer, Barbara Fleming i Karen M. Simon. "The Treatment of Suicidal Behavior". W Clinical Applications of Cognitive Therapy, 101–18. Boston, MA: Springer US, 1990. http://dx.doi.org/10.1007/978-1-4684-0007-6_5.

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Schifano, Fabrizio, i Diego De Leo. "Pharmacological Treatment of Suicidal Behavior". W Suicide Prevention, 199–209. Dordrecht: Springer Netherlands, 1998. http://dx.doi.org/10.1007/0-306-47210-4_21.

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Freeman, Arthur, i David M. White. "The Treatment of Suicidal Behavior". W Comprehensive Handbook of Cognitive Therapy, 321–46. New York, NY: Springer US, 1989. http://dx.doi.org/10.1007/978-1-4757-9779-4_17.

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Ratcliffe, Sian L., Phillip B. Chappell, Janel Boyce-Rustay, Svetlana Gloukhova i Denise M. Oleske. "Treatment Emergent Suicidal Ideation and Behavior". W Suicide: Phenomenology and Neurobiology, 31–58. Cham: Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-09964-4_3.

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Fiske, Amy, Merideth D. Smith i Elizabeth C. Price. "Suicidal behavior in older adults." W APA handbook of clinical geropsychology, Vol. 2: Assessment, treatment, and issues of later life., 145–72. Washington: American Psychological Association, 2015. http://dx.doi.org/10.1037/14459-006.

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Miller, Alec L., Julie S. Nathan i Elizabeth E. Wagner. "Engaging suicidal multiproblem adolescents with dialectical behavior therapy." W Elusive alliance: Treatment engagement strategies with high-risk adolescents., 185–205. Washington: American Psychological Association, 2010. http://dx.doi.org/10.1037/12139-007.

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Hewiitt, Paul L., i Gordon L. Flett. "Perfectionism and goal orientation in impulsive and suicidal behavior." W The impulsive client: Theory, research, and treatment., 247–63. Washington: American Psychological Association, 1993. http://dx.doi.org/10.1037/10500-013.

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Wingate, LaRicka R., Andrea B. Burns, Kathryn H. Gordon, Marisol Perez, Rheeda L. Walker, Foluso M. Williams i Thomas E. Joiner. "Suicide and Positive Cognitions: Positive Psychology Applied to the Understanding and Treatment of Suicidal Behavior." W Cognition and suicide: Theory, research, and therapy., 261–83. Washington: American Psychological Association, 2006. http://dx.doi.org/10.1037/11377-012.

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Oquendo, Maria A., i Alejandro Porras-Segovia. "Barriers for the Research, Prevention, and Treatment of Suicidal Behavior". W Behavioral Neurobiology of Suicide and Self Harm, 25–40. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/7854_2020_159.

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Streszczenia konferencji na temat "Suicidal behaviour – Treatment"

Gao, Junbo, Xiao Xiao, Ao Li, Nianzhi Chu, Qin luo i Namu Yongjin. "Effect of Low Frequency Repetitive Transcranial Magnetic Stimulation Treatment on Non-Suicidal Self-Injury Behaviour and Intention of Depressed Adolescents". W International Conference on Mental Health and Humanities Education (ICMHHE 2020). Paris, France: Atlantis Press, 2020. http://dx.doi.org/10.2991/assehr.k.200425.011.

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Raporty organizacyjne na temat "Suicidal behaviour – Treatment"

Holloway, Marjan G., i Laura L. Neely. Post Admission Cognitive Therapy (PACT) for the Inpatient Treatment of Military Personnel with Suicidal Behaviors: A Multi-Site Randomized Controlled Trial. Fort Belvoir, VA: Defense Technical Information Center, luty 2015. http://dx.doi.org/10.21236/ada614003.

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Holloway, Marjan G. Post Admission Cognitive Therapy (PACT) for the Inpatient Treatment of Military Personnel with Suicidal Behaviors: A Multi-Site Randomized Controlled Trial. Fort Belvoir, VA: Defense Technical Information Center, luty 2013. http://dx.doi.org/10.21236/ada572206.

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Holloway, Marjan. Post Admission Cognitive Therapy (PACT) for the Inpatient Treatment of Military Personnel with Suicidal Behaviors: A Multi-Site Randomized Controlled Trial. Fort Belvoir, VA: Defense Technical Information Center, luty 2012. http://dx.doi.org/10.21236/ada576138.

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Leavy, Michelle B., Danielle Cooke, Sarah Hajjar, Erik Bikelman, Bailey Egan, Diana Clarke, Debbie Gibson, Barbara Casanova i Richard Gliklich. Outcome Measure Harmonization and Data Infrastructure for Patient-Centered Outcomes Research in Depression: Report on Registry Configuration. Agency for Healthcare Research and Quality (AHRQ), listopad 2020. http://dx.doi.org/10.23970/ahrqepcregistryoutcome.

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Background: Major depressive disorder is a common mental disorder. Many pressing questions regarding depression treatment and outcomes exist, and new, efficient research approaches are necessary to address them. The primary objective of this project is to demonstrate the feasibility and value of capturing the harmonized depression outcome measures in the clinical workflow and submitting these data to different registries. Secondary objectives include demonstrating the feasibility of using these data for patient-centered outcomes research and developing a toolkit to support registries interested in sharing data with external researchers. Methods: The harmonized outcome measures for depression were developed through a multi-stakeholder, consensus-based process supported by AHRQ. For this implementation effort, the PRIME Registry, sponsored by the American Board of Family Medicine, and PsychPRO, sponsored by the American Psychiatric Association, each recruited 10 pilot sites from existing registry sites, added the harmonized measures to the registry platform, and submitted the project for institutional review board review Results: The process of preparing each registry to calculate the harmonized measures produced three major findings. First, some clarifications were necessary to make the harmonized definitions operational. Second, some data necessary for the measures are not routinely captured in structured form (e.g., PHQ-9 item 9, adverse events, suicide ideation and behavior, and mortality data). Finally, capture of the PHQ-9 requires operational and technical modifications. The next phase of this project will focus collection of the baseline and follow-up PHQ-9s, as well as other supporting clinical documentation. In parallel to the data collection process, the project team will examine the feasibility of using natural language processing to extract information on PHQ-9 scores, adverse events, and suicidal behaviors from unstructured data. Conclusion: This pilot project represents the first practical implementation of the harmonized outcome measures for depression. Initial results indicate that it is feasible to calculate the measures within the two patient registries, although some challenges were encountered related to the harmonized definition specifications, the availability of the necessary data, and the clinical workflow for collecting the PHQ-9. The ongoing data collection period, combined with an evaluation of the utility of natural language processing for these measures, will produce more information about the practical challenges, value, and burden of using the harmonized measures in the primary care and mental health setting. These findings will be useful to inform future implementations of the harmonized depression outcome measures.

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DBT is effective for youth with high levels of emotion dysregulation. ACAMH, wrzesień 2019. http://dx.doi.org/10.13056/acamh.10649.

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In 2019, Molly Adrian and colleagues examined the predictors and moderators of treatment outcomes for suicidal adolescents who participated in a randomized controlled trial evaluating Dialectical Behaviour Therapy (DBT) versus Individual/Group Supportive Therapy (IGST).

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Effective prevention of suicidal behaviours in adolescents – from targeted treatments to firearms restriction – Professor Lars Mehlum. ACAMH, wrzesień 2019. http://dx.doi.org/10.13056/acamh.8424.

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Professor Lars Mehlum at the launch of the JCPP Special issue 2019 - Suicide and self-harm. Lars looks at 'Effective prevention of suicidal behaviours in adolescents - from targeted treatments to firearms restriction'

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Family-focused CBT is not superior to enhanced treatment-as-usual in reducing suicide attempts. ACAMH, wrzesień 2019. http://dx.doi.org/10.13056/acamh.10651.

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In 2011, Esposito-Smythers et al. reported that integrated outpatient cognitive-behavioural therapy (I-CBT) significantly reduced substance use, suicidal behaviours, and the rate of health service use compared with enhanced treatment-as-usual (E-TAU) in adolescents with co-occurring alcohol or drug use disorder and suicidality.

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