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Artykuły w czasopismach na temat „Spexine”

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Data publikacji: 11 stycznia 2025

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1

Lv, Shuangyu, Yuchen Zhou, Yu Feng, et al. "Peripheral Spexin Inhibited Food Intake in Mice." International Journal of Endocrinology 2020 (August 5, 2020): 1–9. http://dx.doi.org/10.1155/2020/4913785.

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Spexin (SPX, NPQ), a novel endogenous neuropeptide, was firstly identified by bioinformatics. Spexin gene and protein widely distributed in the central nervous system and peripheral tissues, such as the hypothalamus and digestive tract. The role of spexin in appetite regulation in mammalian is still unclear. The present study was designed to investigate the mechanism and effect of peripheral spexin on food intake in mice. During the light period, an intraperitoneal (i.p.) injection of spexin (10 nmol/mouse) significantly inhibited cumulative food intake at 2, 4, and 6 h after treatment in fast

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Liu, Ying, Di Wu, Hangping Zheng, et al. "Serum Spexin Level Is Negatively Associated With Peripheral Neuropathy and Sensory Pain in Type 2 Diabetes." Journal of Diabetes Research 2024 (May 23, 2024): 1–12. http://dx.doi.org/10.1155/2024/4538199.

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Background: Spexin is a novel peptide hormone and has shown antinociceptive effects in experimental mice. This study is aimed at evaluating the association of serum spexin level with diabetic peripheral neuropathy (DPN) and related pain in a Chinese population.Methods: We enrolled 167 type 2 diabetes mellitus (T2DM) including 56 patients without DPN (non-DPN), 67 painless DPN, and 44 painful DPN. Serum spexin was measured using ELISA. Logistic regression models were performed to analyze the independent effects of spexin on prevalence of DPN and painful DPN. In streptozotocin (STZ)-induced diab

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Karaca, Anara, Filiz Bakar-Ates, and Nese Ersoz-Gulcelik. "Decreased Spexin Levels in Patients with Type 1 and Type 2 Diabetes." Medical Principles and Practice 27, no. 6 (2018): 549–54. http://dx.doi.org/10.1159/000493482.

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Background/Aims: Spexin is a novel peptide which has a potential role as a biomarker of insulin resistance, diabetes, and obesity. Our aim was to measure spexin levels in lean type 1 diabetic patients and its relevance to glycemic parameters without the presence of obesity or insulin resistance. Subjects and Methods: This cross-sectional study included 29 type 1 and 30 type 2 diabetic patients and a control group of 23 healthy subjects with adjusted age, sex, and body mass index (BMI). Height and weight were measured using standard techniques. Glucose levels, triglycerides, total cholesterol,

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F. salih, Ruaa, Hala Abd Al-Qadir Al-Moayad Abd Al-Qadir Al-Moayad, Firas abbas, Jalil I. Alezzi, and Asrar Saleh Mohammed. "Association of Spexin Hormone Levels with Metabolic Disturbance in Women with Polycystic Ovarian Syndrome." Diyala Journal of Medicine 27, no. 1 (2024): 12–24. http://dx.doi.org/10.26505/djm.v27i1.1138.

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Background: Polycystic ovarian syndrome is affecting around 5–15% of females. Spexin hormone, identified as neuropeptide Q, has been newly recognized by bioinformatics methods. Objective: To evaluate the relationship concerning levels of spexin hormone with metabolic disruption in women with polycystic ovarian syndrome. Patients and Methods: A case-control study carried out in the department of Obstetrics and Gynecology in Al-Imamain Al-Khademain medical city/Baghdad, Iraq, from Jan 1, 2022, to the end of Dec 31, 2022. The study sample comprises, 192 participants aged 18-45 years were joined a

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Bacopoulou, Flora, Despoina Apostolaki, Aimilia Mantzou, et al. "Serum Spexin is Correlated with Lipoprotein(a) and Androgens in Female Adolescents." Journal of Clinical Medicine 8, no. 12 (2019): 2103. http://dx.doi.org/10.3390/jcm8122103.

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The Spexin gene is considered the most dysregulated in obese human fat. Limited data suggest that the novel peptide spexin may potentially impact food intake, weight regulation and body adiposity. The aim of this case-control study was to compare fasting serum spexin concentrations between normal weight (NW) and overweight/obese (OB/OW) adolescent females and explore the relationship between circulating spexin and anthropometric, bone and fat mass, metabolic and hormonal parameters. Eighty post-menarcheal females (mean age ± SD 16.23 ± 2.26 years); 55 NW (mean BMI ± SD 19.72 ± 2.52 kg/m2) and

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Ozturk Onsal, Fatma Duygu, Ahmet Ucar, Ali Bulbul, Zeynep Yildiz Yildirmak, and Gizem Kara Elitok. "Associations of Size at Birth and Metabolic Syndrome Antecedents With Serum Spexin Levels in Prepubertal Children." Journal of the Endocrine Society 5, Supplement_1 (2021): A709—A710. http://dx.doi.org/10.1210/jendso/bvab048.1445.

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Abstract Background: Spexin is a novel peptide implicated in food intake and obesity. The primary aim of this study was to analyze whether serum spexin levels, along with total leptin and active ghrelin levels were different in prepubertal children born small for gestational age(SGA) and appropriate for gestational(AGA). Secondary aims were to analyze whether serum spexin, leptin and active ghrelin levels correlated with metabolic syndrome(MS)antecedents according to the Dietary and lifestyle-induced health effects in children and infants (IDEFICS)study. Subjects and Methods: We conducted a cr

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7

Cichoń, Lena, Artur Pałasz, Krzysztof M. Wilczyński, et al. "Evaluation of Peripheral Blood Concentrations of Phoenixin, Spexin, Nesfatin-1 and Kisspeptin as Potential Biomarkers of Bipolar Disorder in the Pediatric Population." Biomedicines 12, no. 1 (2023): 84. http://dx.doi.org/10.3390/biomedicines12010084.

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There are some initial suggestions in the literature that phoenixin, spexin, nesfatin-1 and kisspeptin may play a role in the pathogenesis of affective disorders. Therefore, they may also be cautiously considered as potential diagnostic or predictive biomarkers of BD. This study aimed to evaluate the levels of the aforementioned neuropeptides in the peripheral blood of children and adolescents with bipolar. This study included 122 individuals: 67 persons with diagnosed bipolar disorder types I and II constituted the study group, and 55 healthy persons were included in the control group. Statis

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Yazgan, Burak, Filiz Avcı, Gülsün Memi, and Ebru Tastekin. "Inflammatory response and matrix metalloproteinases in chronic kidney failure: Modulation by adropin and spexin." Experimental Biology and Medicine 246, no. 17 (2021): 1917–27. http://dx.doi.org/10.1177/15353702211012417.

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Chronic kidney disease is a major global public health problem. The peptide hormones adropin and spexin modulate many physiological functions such as energy balance and glucose, lipid and protein metabolism. However, it is unclear whether these peptides may exert effects on renal damage, tissue remodeling, and inflammatory conditions. In view of the limited information, we aimed to investigate the effect of adropin and spexin on matrix metalloproteinase and inflammatory response genes a rat model of adenine-induced chronic kidney failure. Chronic kidney failure was induced in rats by administe

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9

Ghannawi,, L. A., K. Gharab,, M. A. Hadi,, O. Y. Shakir,, and A. M. Rahmah. "Spexin level in growth hormone deficiency Iraqi children." Ukrainian Biochemical Journal 96, no. 4 (2024): 55–61. http://dx.doi.org/10.15407/ubj96.04.055.

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Spexin (SPX) is a newly discovered brain adipokine implicated in various homeostatic functions including metabolism, energy balance, endocrine processes and growth hormone (GH) production in particular. At the same time, the growth-promoting effects of GH are influenced by Insulin-like growth factor-1 (IGF‑1) and vitamin D3. The aim of this study was to investigate the possible involvement of SPX in growth hormone deficiency (GHD) in children. The research involved 90 children (40 with growth hormone deficiency and 50 healthy controls aged 5-14). Serum levels of GH, IGF and vitamin D3 were tes

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Abdualhay, Raghda Abdulsamad, and Adnan Jassim Mohammed Al-Fartosy. "Insulin Resistance and Other Adipokines as Clinical Predictors of Gestational Diabetes Mellitus among Pregnant Women." Indonesian Biomedical Journal 14, no. 3 (2022): 243–51. http://dx.doi.org/10.18585/inabj.v14i3.1934.

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BACKGROUND: Gestational diabetes mellitus (GDM) has a strong relationship with an increased risk of maternal and perinatal complications. However, in Basrah, Iraq, studies regarding GDM are still limited. In current study, we aimed to investigate the association between insulin resistance and some clinical predictors of GDM among pregnant women in 1st and 3rd trimesters of gestation.METHODS: This case-control study was conducted on 44 pregnant women with GDM and 45 without GDM aged 20 to 40 years who applied for GDM screening during the first (9-13 week) and third trimester (24-28 week) of pre

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11

Cheshmazar, Elhameh, Agha Fatemeh Hosseini, Bahareh Yazdani, Elham Razmpoosh, and Mitra Zarrati. "Effects of Vitamin D Supplementation on Omentin-1 and Spexin Levels, Inflammatory Parameters, Lipid Profile, and Anthropometric Indices in Obese and Overweight Adults with Vitamin D Deficiency under Low-Calorie Diet: A Randomized Placebo Controlled Trial." Evidence-Based Complementary and Alternative Medicine 2020 (November 10, 2020): 1–10. http://dx.doi.org/10.1155/2020/3826237.

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Background and Aims. Improved vitamin D levels can have a favorable effect on some metabolic variables. The objective of the current study was to determine the effects of vitamin D supplementation during a weight-loss intervention on the levels of omentin-1, spexin, lipid profiles, and inflammatory factors in obese and overweight participants. Methods and Materials. In this double-blind placebo-controlled randomized clinical trial, 70 overweight and obese participants with vitamin D deficiency (25(OH)D ≤ 20 nmol/L) were assigned into the intervention (a daily dose of 2,000 IU vitamin D + low-c

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12

Gambaro, Sabrina E., Guillermina Maria Zubiria, Alejandra P. Giordano, Ezequiel A. Harnichar, Andrea E. Portales, and Andrés Giovambattista. "Spexin Friend or Foe? Novel Role of Spexin During Thermogenesis of White Adipose Tissue." Journal of the Endocrine Society 5, Supplement_1 (2021): A58. http://dx.doi.org/10.1210/jendso/bvab048.117.

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Abstract Spexin (SPX) is a novel adipokine playing an emerging role in metabolic diseases due to its involvement in carbohydrate homeostasis, weight loss, appetite control, gastrointestinal movement, among others. Moreover, plasma levels are reduced in obese and type II diabetic patients. In vitro, SPX favors lipolysis in adipocytes and hepatocytes and inhibits white adipogenesis. Therefore, the aim of this study was to evaluate the role of SPX in white adipose tissue (AT) thermogenesis. C57BL/6J male mice were treated or not with SPX for ten days (ip. 29 µg/kg/day; CTR and SPX). At day 3 mice

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Pałasz, Artur, Piotr Żarczyński, Katarzyna Bogus, et al. "Modulatory effect of olanzapine on SMIM20/phoenixin, NPQ/spexin and NUCB2/nesfatin-1 gene expressions in the rat brainstem." Pharmacological Reports 73, no. 4 (2021): 1188–94. http://dx.doi.org/10.1007/s43440-021-00267-7.

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Abstract Background Phoenixin, spexin and nesfatin-1 belong to a family of newly discovered multifunctional neuropeptides that play regulatory roles in several brain structures and modulate the activity of important neural networks. However, little is known about their expression and action at the level of brainstem. The present work was, therefore, focused on gene expression of the aforementioned peptides in the brainstem of rats chronically treated with olanzapine, a second generation antipsychotic drug. Methods Studies were carried out on adult, male Sprague–Dawley rats that were divided in

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Gajewska, Joanna, Katarzyna Szamotulska, Witold Klemarczyk, Magdalena Chełchowska, Małgorzata Strucińska, and Jadwiga Ambroszkiewicz. "Circulating Levels of Nesfatin-1 and Spexin in Children with Prader-Willi Syndrome during Growth Hormone Treatment and Dietary Intervention." Nutrients 15, no. 5 (2023): 1240. http://dx.doi.org/10.3390/nu15051240.

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Background: Despite observable improvement in the treatment outcomes of patients with Prader-Willi syndrome (PWS), adequate weight control is still a clinical problem. Therefore, the aim of this study was to analyze the profiles of neuroendocrine peptides regulating appetite—mainly nesfatin-1 and spexin—in children with PWS undergoing growth hormone treatment and reduced energy intake. Methods: Twenty-five non-obese children (aged 2–12 years) with PWS and 30 healthy children of the same age following an unrestricted age-appropriate diet were examined. Serum concentrations of nesfatin-1, spexin

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Kim, Dong-Kyu, Seongsik Yun, Gi Hoon Son, et al. "Coevolution of the Spexin/Galanin/Kisspeptin Family: Spexin Activates Galanin Receptor Type II and III." Endocrinology 155, no. 5 (2014): 1864–73. http://dx.doi.org/10.1210/en.2013-2106.

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The novel neuropeptide spexin (SPX) was discovered using bioinformatics. The function of this peptide is currently under investigation. Here, we identified SPX along with a second SPX gene (SPX2) in vertebrate genomes. Syntenic analysis and relocating SPXs and their neighbor genes on reconstructed vertebrate ancestral chromosomes revealed that SPXs reside in the near vicinity of the kisspeptin (KISS) and galanin (GAL) family genes on the chromosomes. Alignment of mature peptide sequences showed some extent of sequence similarity among the 3 peptide groups. Gene structure analysis indicated tha

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Tsikerdekis, Athanasios, Nick A. J. Schutgens, Guangliang Fu, and Otto P. Hasekamp. "Estimating aerosol emission from SPEXone on the NASA PACE mission using an ensemble Kalman smoother: observing system simulation experiments (OSSEs)." Geoscientific Model Development 15, no. 8 (2022): 3253–79. http://dx.doi.org/10.5194/gmd-15-3253-2022.

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Abstract. We present a top-down approach for aerosol emission estimation from Spectropolarimeter for Planetary Exploration (SPEXone) polarimetric retrievals related to the aerosol amount, size, and absorption using a fixed-lag ensemble Kalman smoother (LETKS) in combination with the ECHAM-HAM model. We assess the system by performing observing system simulation experiments (OSSEs) in order to evaluate the ability of the future multi-angle polarimeter instrument, SPEXone, as well as a satellite with near-perfect global coverage. In our OSSEs, the nature run (NAT) is a simulation by the global c

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Gowdu, Tejaswi, and Dayanand CD. "Spexin in Metabolic Syndrome-An Overview." SAS Journal of Medicine 7, no. 1 (2021): 15–25. http://dx.doi.org/10.36347/sasjm.2021.v07i01.005.

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Porzionato, Andrea, Marcin Rucinski, Veronica Macchi, Carla Stecco, Ludwik K. Malendowicz, and Raffaele De Caro. "Spexin Expression in Normal Rat Tissues." Journal of Histochemistry & Cytochemistry 58, no. 9 (2010): 825–37. http://dx.doi.org/10.1369/jhc.2010.956300.

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Jeong, Inyoung, Eunmi Kim, Suhyun Kim, Jae Young Seong, and Hae-Chul Park. "Neuronal circuit of spexin 1/2 neurons and its role of spexin 1 in the zebrafish habenula." IBRO Reports 6 (September 2019): S432—S433. http://dx.doi.org/10.1016/j.ibror.2019.07.1374.

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Fan, Cheng, Guangliang Fu, Antonio Di Noia, et al. "Use of A Neural Network-Based Ocean Body Radiative Transfer Model for Aerosol Retrievals from Multi-Angle Polarimetric Measurements." Remote Sensing 11, no. 23 (2019): 2877. http://dx.doi.org/10.3390/rs11232877.

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For aerosol retrieval from multi-angle polarimetric (MAP) measurements over the ocean it is important to accurately account for the contribution of the ocean-body to the top-of-atmosphere signal, especially for wavelengths <500 nm. Performing online radiative transfer calculations in the coupled atmosphere ocean system is too time consuming for operational retrieval algorithms. Therefore, mostly lookup-tables of the ocean body reflection matrix are used to represent the lower boundary in an atmospheric radiative transfer model. For hyperspectral measurements such as those from Spectro-Polar

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Sun, Xiaotong, Ziwei Yu, Yuxin Xu, Shengdan Pu, and Xinyuan Gao. "The role of spexin in energy metabolism." Peptides 164 (June 2023): 170991. http://dx.doi.org/10.1016/j.peptides.2023.170991.

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Rucinski, Marcin, Andrea Porzionato, Agnieszka Ziolkowska, et al. "Expression of the spexin gene in the rat adrenal gland and evidences suggesting that spexin inhibits adrenocortical cell proliferation." Peptides 31, no. 4 (2010): 676–82. http://dx.doi.org/10.1016/j.peptides.2009.12.025.

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Jeong, Bora, Kwang-Kon Kim, Tae-Hwan Lee, et al. "Spexin Regulates Hypothalamic Leptin Action on Feeding Behavior." Biomolecules 12, no. 2 (2022): 236. http://dx.doi.org/10.3390/biom12020236.

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Spexin (SPX) is a recently identified neuropeptide that is believed to play an important role in the regulation of energy homeostasis. Here, we describe a mediating function of SPX in hypothalamic leptin action. Intracerebroventricular (icv) SPX administration induced a decrease in food intake and body weight gain. SPX was found to be expressed in cells expressing leptin receptor ObRb in the mouse hypothalamus. In line with this finding, icv leptin injection increased SPX mRNA in the ObRb-positive cells of the hypothalamus, which was blocked by treatment with a STAT3 inhibitor. Leptin also inc

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Al-Daghri, Nasser M., Amal Alenad, Hazim Al-Hazmi, Osama E. Amer, Syed Danish Hussain, and Majed S. Alokail. "Spexin Levels Are Associated with Metabolic Syndrome Components." Disease Markers 2018 (September 4, 2018): 1–5. http://dx.doi.org/10.1155/2018/1679690.

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Background. Spexin (SPX) is a novel peptide that is implicated in obesity and related energy homeostasis in animals and adult humans. Little is known about its role in adults’ overall cardiometabolic health. The aim of the study was to determine whether circulating levels of spexin (SPX) is associated with components of metabolic syndrome (MetS).Methods. The present cross-sectional study included 124 participants (41 males and 83 females; aged 42.4 ± 10.3 y) (MetS group) and 136 (21 male and 115 females; aged 33.1 ± 8.7 y) (non-MetS group). SPX was measured using commercially available assays.

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Ma, Ani, Jin Bai, Mulan He, and Anderson O. L. Wong. "Spexin as a neuroendocrine signal with emerging functions." General and Comparative Endocrinology 265 (September 2018): 90–96. http://dx.doi.org/10.1016/j.ygcen.2018.01.015.

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Sassek, Maciej, Pawel A. Kolodziejski, Mathias Z. Strowski, Leszek Nogowski, Krzysztof W. Nowak, and Pawel Mackowiak. "Spexin Modulates Functions of Rat Endocrine Pancreatic Cells." Pancreas 47, no. 7 (2018): 904–9. http://dx.doi.org/10.1097/mpa.0000000000001083.

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Kumar, Seema, Jobayer Hossain, Nicole Nader, Roxana Aguirre, Swetha Sriram, and P. Babu Balagopal. "Decreased Circulating Levels of Spexin in Obese Children." Journal of Clinical Endocrinology & Metabolism 101, no. 7 (2016): 2931–36. http://dx.doi.org/10.1210/jc.2016-1177.

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Stupin, Jens H. "Ist Spexin ein Ansatzpunkt gegen Adipositas bei Kindern?" Info Diabetologie 10, no. 4 (2016): 29–30. http://dx.doi.org/10.1007/s15034-016-0922-0.

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Fang, Penghua, Yuqing She, Mei Yu, et al. "Novel hypothalamic pathways for metabolic effects of spexin." Pharmacological Research 208 (October 2024): 107399. http://dx.doi.org/10.1016/j.phrs.2024.107399.

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Zhuang, Min, Qi Lai, Chunju Yang, et al. "Spexin as an anxiety regulator in mouse hippocampus: Mechanisms for transcriptional regulation of spexin gene expression by corticotropin releasing factor." Biochemical and Biophysical Research Communications 525, no. 2 (2020): 326–33. http://dx.doi.org/10.1016/j.bbrc.2020.02.023.

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Meng, Fengyan, Yuping Wu, Yu Yu, et al. "Spexin2 Is a Novel Food Regulator in Gallus gallus." International Journal of Molecular Sciences 24, no. 5 (2023): 4821. http://dx.doi.org/10.3390/ijms24054821.

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Spexin2 (SPX2), a paralog of SPX1, is a newly identified gene in non-mammalian vertebrates. Limited studies in fish have evidenced its important role in food intake and energy balance modulation. However, little is known about its biological functions in birds. Using the chicken (c-) as a model, we cloned the full-length cDNA of SPX2 by using RACE-PCR. It is 1189 base pair (bp) in length and predicted to generate a protein of 75 amino acids that contains a 14 amino acids mature peptide. Tissue distribution analysis showed that cSPX2 transcripts were detected in a wide array of tissues, with ab

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ONAT, Elif, and Nevin KOCAMAN. "Liver Protection of Hydroxytyrosol Mediated by Spexin and TRPM2." Journal of Contemporary Medicine 13, no. 5 (2023): 954–58. http://dx.doi.org/10.16899/jcm.1352503.

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Background/Aim: In the study, the role of Spexin (SPX) and TRPM2 in the protective effect of Hydroxytyrosol (HT) in rats given Corn Syrup was evaluated. Material and Method: The rats were divided into 4 groups (6 rats in each) (Control, HT, Corn Syrup, Corn Syrup +HT). Rats were given 30% Corn Syrup with drinking water for 6 weeks. 4 ml/kg/day liquid containing HT was applied by oral gavage alone and together with Corn Syrup for 6 weeks. Molecular parameters SPX and TRPM2 were examined histopathologically in liver tissue.  Results: The SPX levels decreased and the TRPM2 levels incr

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Wojciechowska, Malgorzata, Pawel A. Kolodziejski, Ewa Pruszynska-Oszmalek, et al. "Cord Blood Spexin Level in Mothers with Obesity—Forecast of Future Obesity?" Children 10, no. 9 (2023): 1517. http://dx.doi.org/10.3390/children10091517.

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Spexin (SPX) is a peptide that plays an important role in the regulation of food intake and body weight (BW) by the effect on carbohydrate-lipid metabolism. However, the role of SPX in fetal life, in children, and in adolescent metabolism is limited. Therefore, we decided to check whether obesity affects the concentration of SPX in the mother’s peripheral blood (MB) and umbilical cord blood (UCB). Using MB and UCB sera on the day of delivery obtained from 48 women (24 non-obese and 24 obese) and commercially available Elisa kits and colorimetric assays, we determined changes in SPX and the rel

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Kołodziejski, Paweł A., Ewa Pruszyńska-Oszmałek, Marcin Hejdysz, et al. "Effect of Fasting on the Spexin System in Broiler Chickens." Animals 11, no. 2 (2021): 518. http://dx.doi.org/10.3390/ani11020518.

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Spexin (SPX) is a highly conservative peptide hormone containing 14 amino acids and was discovered in 2007 by bioinformatics methods. However, nothing is yet known about its role in the metabolism of birds, including broilers. The aim of this study was to investigate the effect of short-term fasting (2, 4, and 8 h) on the concentration of SPX in blood serum and the expression levels of the genes encoding this peptide (SPX1) and its receptors, GALR2 and GALR3, in the tissues involved in carbohydrate and lipid metabolism (muscles, adipose tissue, and liver). We also analyzed the mRNA expression

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DARAKCI SALTIK, Özge, and Ayhan BOZKURT. "Structure and functions of spexin as a new neuroendocrine signal." Journal of Experimental and Clinical Medicine 39, no. 3 (2022): 893–900. http://dx.doi.org/10.52142/omujecm.39.3.56.

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Spexin (SPX ) is a recently discovered endogenous peptide consisting of 14 amino acids. It was found that SPX, kisspeptin (KISS), and galanin (GAL) peptides belong to the same gene family and are also endogenous ligands of GAL2 and GAL3 receptors. The amino acid sequence of the SPX peptide is relatively conserved in vertebrates and invertebrates. The mRNA and protein of SPX are highly expressed both in peripheral organs and in the peripheral/central nervous system of mammals, birds, and fishes. Many biological roles of SPX has been found in non- mammal/mammals, including food intake, energy me

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Fang, Penghua, Ran Ge, Yuqing She, et al. "Adipose tissue spexin in physical exercise and age-associated diseases." Ageing Research Reviews 73 (January 2022): 101509. http://dx.doi.org/10.1016/j.arr.2021.101509.

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LIU, RUI. "248-LB: Spexin Promotes Insulin Secretion and ß-Cell Proliferation." Diabetes 69, Supplement 1 (2020): 248—LB. http://dx.doi.org/10.2337/db20-248-lb.

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Kolodziejski, Pawel A., Ewa Pruszynska-Oszmalek, Maciej Micker, et al. "Spexin: A novel regulator of adipogenesis and fat tissue metabolism." Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1863, no. 10 (2018): 1228–36. http://dx.doi.org/10.1016/j.bbalip.2018.08.001.

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Liu, Yang, Li Sun, Linqun Zheng, et al. "Spexin protects cardiomyocytes from hypoxia-induced metabolic and mitochondrial dysfunction." Naunyn-Schmiedeberg's Archives of Pharmacology 393, no. 1 (2019): 25–33. http://dx.doi.org/10.1007/s00210-019-01708-0.

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Heijman, Jordi, and Dobromir Dobrev. "Spexin Hormone Signaling and Atrial Fibrillation: The Knowns and Unknowns." Circulation 150, no. 2 (2024): 128–31. http://dx.doi.org/10.1161/circulationaha.124.070016.

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Aksu, Oguzhan, Ummugulsum Can, Selma Ozlem Celikdelen, Betul Cigdem Yortanli, Muhammet Cemal Kizilarslanoglu, and Ayse Gunay. "Evaluation of spexin levels in euthyroid patients with Hashimoto thyroiditis and its relation to autoimmunity." Medicine 103, no. 43 (2024): e40321. http://dx.doi.org/10.1097/md.0000000000040321.

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Hashimoto thyroiditis (HT) is chronic lymphocytic thyroiditis. Cytokines and chemokines such as tumor necrosis factor-alpha, interferon-gamma, and interleukin-1 beta originating from immune cells are involved in the etiopathogenesis of HT. Spexin (SPX) is a recently identified novel peptide hormone consisting of 14 amino acids and has been demonstrated in follicle epithelial cells in thyroid tissue. SPX has been shown to affect the inflammatory response and play a role in its regulation in various diseases. There is a need for markers for diagnosis and treatment of HT patients with negative an

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Simsir, Coskun, Muberra Namli Kalem, Ziya Kalem, et al. "Circulating Spexin levels in pregnant women with and without gestational diabetes." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 8, no. 10 (2019): 4056. http://dx.doi.org/10.18203/2320-1770.ijrcog20194380.

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Background: Several previous studies suggest that SPX plays a role in appetite control and body weight and blood glucose regulation. The aim of this study to determine SPX levels in healthy pregnancies and in gestational diabetes (GDM) and to investigate the association of SPX levels with weight gain and lipid and glucose metabolism in subjects with and without GDM.Methods: A total of 44 women with GDM and 44 women without GDM were randomly enrolled who applied for GDM screening during the 24-28th week of pregnancy. Demographics, blood glucose and lipid profiles and Spexin levels were compared

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Lai, Qi, Yanhua Ma, Jin Bai, et al. "Mechanisms for Bile Acids CDCA- and DCA-Stimulated Hepatic Spexin Expression." Cells 11, no. 14 (2022): 2159. http://dx.doi.org/10.3390/cells11142159.

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Spexin (SPX) is a novel peptide involved in glucose and lipid metabolism and suppresses hepatic total bile acid levels by inhibiting hepatic cholesterol 7α-hydroxylase 1 expression. As important mediators for glycolysis/gluconeogenesis and lipid metabolism, the effects of bile acids on SPX expression is yet to be understood. By using SMMC7721 and BEL-7402 cell lines, we screened the effects of bile acids and found that chenodeoxycholic acid (CDCA) and deoxycholic acid (DCA) can stimulate SPX gene transcription. Both CDCA and DCA were able to stimulate SPX mRNA expression in the liver but not c

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Yu, Mei, Mengyuan Wang, Shiyu Han, et al. "Spexin ameliorates skeletal muscle insulin resistance through activation of GAL2 receptor." European Journal of Pharmacology 917 (February 2022): 174731. http://dx.doi.org/10.1016/j.ejphar.2021.174731.

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Türkel, İbrahim, Gülsün Memi, and Burak Yazgan. "Impact of spexin on metabolic diseases and inflammation: An updated minireview." Experimental Biology and Medicine 247, no. 7 (2022): 567–73. http://dx.doi.org/10.1177/15353702211072443.

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Spexin (SPX) is a 14 amino acid length peptide hormone which was discovered using bioinformatic tools. It is extensively expressed in central and peripheral tissues and secreted into circulation in response to metabolic stress. Recent studies revealed that SPX acts as a multifunctional peptide in various metabolic processes such as body weight, food intake, energy balance, glucose and lipid metabolism, lipid storage, salt–water balance, and arterial blood pressure. Endogenous SPX is sensitive to metabolic changes, and circulating levels of SPX have been shown to be reduced in chronic diseases

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Pałasz, Artur, Aleksandra Suszka-Świtek, Łukasz Filipczyk, et al. "Escitalopram affects spexin expression in the rat hypothalamus, hippocampus and striatum." Pharmacological Reports 68, no. 6 (2016): 1326–31. http://dx.doi.org/10.1016/j.pharep.2016.09.002.

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Gambaro, Sabrina Eliana, María Guillermina Zubiría, Alejandra Paula Giordano, et al. "“Spexin improves adipose tissue inflammation and macrophage recruitment in obese mice”." Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1865, no. 7 (2020): 158700. http://dx.doi.org/10.1016/j.bbalip.2020.158700.

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Pałasz, Artur, Aleksandra Suszka-Świtek, Andrzej Kaśkosz, et al. "Spexin-expressing neurons in the magnocellular nuclei of the human hypothalamus." Journal of Chemical Neuroanatomy 111 (January 2021): 101883. http://dx.doi.org/10.1016/j.jchemneu.2020.101883.

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Sassek, Maciej, Pawel A. Kolodziejski, Dawid Szczepankiewicz, and Ewa Pruszynska-Oszmalek. "Spexin in the physiology of pancreatic islets—mutual interactions with insulin." Endocrine 63, no. 3 (2018): 513–19. http://dx.doi.org/10.1007/s12020-018-1766-2.

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Kołodziejski, Paweł A., Ewa Pruszyńska-Oszmałek, Tatiana Wojciechowicz, et al. "The Role of Peptide Hormones Discovered in the 21st Century in the Regulation of Adipose Tissue Functions." Genes 12, no. 5 (2021): 756. http://dx.doi.org/10.3390/genes12050756.

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Peptide hormones play a prominent role in controlling energy homeostasis and metabolism. They have been implicated in controlling appetite, the function of the gastrointestinal and cardiovascular systems, energy expenditure, and reproduction. Furthermore, there is growing evidence indicating that peptide hormones and their receptors contribute to energy homeostasis regulation by interacting with white and brown adipose tissue. In this article, we review and discuss the literature addressing the role of selected peptide hormones discovered in the 21st century (adropin, apelin, elabela, irisin,

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