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Artykuły w czasopismach na temat „Social life and cutosms”

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Autor: Grafiati

Data publikacji: 27 lipca 2024

Data aktualizacji: 29 lipca 2024

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van der Steen, Jenny, Margot de Waal i Wilco Achterberg. "Pain Assessment in Impaired Cognition (PAIC15) Instrument: Cutoffs Against Three Standards". Innovation in Aging 5, Supplement_1 (1.12.2021): 164. http://dx.doi.org/10.1093/geroni/igab046.630.

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Abstract Observational pain scales can help identify pain in persons with impaired cognition including dementia who may have difficulty expressing pain verbally. The Pain Assessment in Impaired Cognition-15 (PAIC15) observational pain scale covers 15 important items that are indicative of pain, but it is unclear how likely pain is for persons with each summed score (theoretical range 0-45). The goal of our study was to determine sensitivity and specificity of cut offs for probable pain on the PAIC15 against three possible standards. We determined cut offs against (1) self report when able, (2) the established Pain Assessment in Advanced Dementia (PAINAD) cut off of 2, and (3) observer’s overall estimate based on a series of systematic observations. We used data of 238 nursing home residents with dementia who were observed by their physician in training or nursing staff in the context of an evidence-based medicine (EBM) training study, with 137 residents assessed twice. The area under the ROC curve was excellent against the PAINAD cut off (□0.8) at both assessments, but acceptable or less than acceptable for the other two standards. Across standards and criteria for optimal sensitivity and specificity, cut offs at the PAIC15 could be 3 or 4. Guided by self report we recommend PAIC15 scores of 3 and higher to represent probable pain with sensitivity and specificity in the 0.5 to 0.7 range.

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Pek, Kalene, Justin Chew, Jun Pei Lim, Suzanne Yew, Cai Ning Tan, Audrey Yeo, Yew Yoong Ding i Wee Shiong Lim. "Social Frailty Is Independently Associated with Mood, Nutrition, Physical Performance, and Physical Activity: Insights from a Theory-Guided Approach". International Journal of Environmental Research and Public Health 17, nr 12 (14.06.2020): 4239. http://dx.doi.org/10.3390/ijerph17124239.

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Notwithstanding the increasing body of evidence that links social determinants to health outcomes, social frailty is arguably the least explored among the various dimensions of frailty. Using available items from previous studies to derive a social frailty scale as guided by the Bunt social frailty theoretical framework, we aimed to examine the association of social frailty, independently of physical frailty, with salient outcomes of mood, nutrition, physical performance, physical activity, and life–space mobility. We studied 229 community-dwelling older adults (mean age 67.22 years; 72.6% females) who were non-frail (defined by the FRAIL criteria). Using exploratory factor analysis, the resultant 8-item Social Frailty Scale (SFS-8) yielded a three-factor structure comprising social resources, social activities and financial resource, and social need fulfilment (score range: 0–8 points). Social non-frailty (SNF), social pre-frailty (SPF), and social frailty (SF) were defined based on optimal cutoffs, with corresponding prevalence of 63.8%, 28.8%, and 7.4%, respectively. In logistic regression adjusted for significant covariates and physical frailty (Modified Fried criteria), there is an association of SPF with poor physical performance and low physical activity (odds ratio, OR range: 3.10 to 6.22), and SF with depressive symptoms, malnutrition risk, poor physical performance, and low physical activity (OR range: 3.58 to 13.97) compared to SNF. There was no significant association of SPF or SF with life–space mobility. In summary, through a theory-guided approach, our study demonstrates the independent association of social frailty with a comprehensive range of intermediary health outcomes in more robust older adults. A holistic preventative approach to frailty should include upstream interventions that target social frailty to address social gradient and inequalities.

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Nikitin, Stanislav Kolpakov, Arseniy Yashkin i Igor Akushevich. "LOCALIZATION OF Β-AMYLOID PLAQUES IN THE BRAINS OF WAR VETERANS, PARTICIPANTS OF THE DOD-ADNI STUDY". Innovation in Aging 7, Supplement_1 (1.12.2023): 688–89. http://dx.doi.org/10.1093/geroni/igad104.2236.

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Abstract We examined the allocation of β-amyloid (Aβ) plaques in the brains of Veterans, long-time survivors of traumatic brain injury (TBI), and those, who did not report brain trauma, and compared it with a spatial distribution of Aβ plaques in the brains of participants of the ADNI program as well as with the pattern of the spatial distribution of Aβ in the brains of participants of ADNI with Alzheimer’s disease. This study included 675 community-dwelling male participants from the ADNI and DoD-ADNI databases (137 veterans, 131 cases of TBI, and 123 AD cases) 62 years old or older. We performed regression analysis, using a pseudo-randomization algorithm, and propensity-score inverse-probability weighting to equalize the subsamples for fourteen outcomes, 12 standardized uptake value ratio variables, and 0.79 and 1.11 cutoffs. Race, educational level, geriatric depression score, age when florbetapir-18 (18F) PET scans were performed, APOE genotype, and Modified Hachinski Ischemic Score were used as predictors. The pattern common for AD showed the highest levels of β-amyloid in the cingulate cortex as well as in the frontal, parietal, and temporal lobes. Veterans have shown a statistically significant increase of 18F concentration in the cerebellum gray matter along with a lower concentration of it in the whole cerebrum as well as in neocortical regions than patients, who did not participate in combats. The continuous exposition to micro-TBI events, which does not necessarily suppose the loss of consciousness or severe contusion likely can explain the high concentration of 18F in cerebellum gray matter in ex-combatants.

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Le, Qun, Linda Churchill, Kevin Kane, Lingming Chen, Scott Crouter, Sarah Berry, Marian Hannan i Wenjun Li. "RACIAL DIFFERENCES IN ASSOCIATION OF OBJECTIVELY MEASURED PHYSICAL ACTIVITY WITH INDOOR AND OUTDOOR FALLS". Innovation in Aging 7, Supplement_1 (1.12.2023): 238. http://dx.doi.org/10.1093/geroni/igad104.0783.

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Abstract Fall-related injury and hospitalization rates have been steadily increasing by 2% and 4% per year. Physical Activity Guidelines advise older adults to remain physically active to promote muscle strength, bone health, and balance. The Healthy Aging and Neighborhood Study enrolled 379 community-dwelling persons aged 65 years or older in Central Massachusetts (2018-2020). Participant physical activity (PA) levels were measured using waist-worn Actigraphy accelerometers for at least 8 hours per day for 5 or more days including 1 weekend day. Average daily PA intensities were categorized according to minutes of sedentary (SB), light (LPA), and moderate-to-vigorous-intensity PA (MVPA) using Copeland cutoffs. Falls, including the circumstances of the fall, were ascertained using monthly falls calendars and follow-up telephone interviews. Negative Binomial Regressions were used to estimate the associations of PA with rates of indoor and outdoor falls. Models were run overall and by race, with all models adjusting for age and gender. Mean age was 73.71(SD:6.41) years, 58.31%(n=221) were female, and 35.62%(n=135) were non-White. There was no significant difference in SB, LPA, and MVPA by race. White race was associated with higher rates of outdoor falls (RR(95% CI)=2.73 (1.51, 4.93)). Every 30 more minutes of MVPA was significantly associated with 25% lower rate of indoor falls (RR(95% CI)=0.74 (0.58, 0.97)) and 42% higher rate of outdoor falls (RR(95% CI)=1.42 (1.04, 1.95)) among non-White but not White (p for interaction=0.03, 0.07, respectively). Socioeconomic factors may explain the differences observed by race. Thus, future investigations should consider socioeconomic when examining indoor and outdoor falls.

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Kim, Seulgi, Ariela Orkaby, Catherine Park, Molly Horstman, Salim Virani, Orna Intrator, Aanand Naik i Javad Razjouyan. "REVISITING ELECTRONIC FRAILTY INDEX BY ADDING A LAB-BASED MARKER OF NUTRITION: A HEART FAILURE COHORT". Innovation in Aging 6, Supplement_1 (1.11.2022): 747–48. http://dx.doi.org/10.1093/geroni/igac059.2717.

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Abstract Malnutrition is associated with worse prognosis and increased risk for adverse outcomes in patients hospitalized with heart failure (HF). The objective is to assess the utility of adding the Prognostic Nutritional Index (PNI), a validated measure of nutritional status, to the Veterans Health Administration frailty index (VA-FI) in predicting time to death in patients hospitalized with HF. We conducted a retrospective cohort study of veterans age ≥50 years hospitalized with HF as their primary diagnosis. PNI was calculated using lab values in the year prior to hospitalization with the following equation: 10 x serum albumin (g/dL)+0.005 x total lymphocyte count (mm3). VA-FI identified five groups: robust (≤0.1), prefrail (0.1–0.2), frail (0.2–0.3), moderately frail (0.3–0.4), and severely frail (>0.4). PNI was added to VA-FI (VA-FI-Nutrition) using the same cutoffs. We identified changes in frailty status using VA-FI versus VA-FI-Nutrition by summarizing the count by each class and reported the hazard ratio (HR) for all-cause mortality in each VA-FI category based on the new VA-FI-Nutrition groups. VA-FI-Nutrition identified patients within each VA-FI class that belong to the next frailty strata: robust (20.2%), prefrail (18.3%), frail (16.7%) and moderately frail (16.7%). We observed higher mortality rates among those whose frailty class changed based on VA-FI-Nutrition compared to VA-FI: robust (HR, 1.65, 95%CI:1.38, 1.97), prefrail (HR, 1.52, 95%CI: 1.41, 1.65), frail (HR, 1.42, 95%CI: 1.33, 1.52), and moderately frail (HR, 1.33, 95%CI: 1.24, 1.43). Adding PNI to VA-FI provides a more accurate mortality assessment and may be utilized to triage high-risk patients.

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Thompson, Carrie A., Kathleen Yost, Melissa C. Larson, Cristine Allmer, Matthew J. Maurer, Amylou C. Dueck, Tait D. Shanafelt i in. "Changes in Quality of Life in Indolent Non-Hodgkin Lymphoma 3 Years after Diagnosis". Blood 130, Suppl_1 (7.12.2017): 917. http://dx.doi.org/10.1182/blood.v130.suppl_1.917.917.

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Abstract Background: Most indolent non-Hodgkin lymphomas (NHL) are considered incurable and are characterized by relapse and remission. Quality of life (QOL) can be affected by disease burden, side effects of treatment, and psychosocial effects of living with an incurable cancer. However, little is known about QOL in this population. We sought to describe QOL at diagnosis, change in QOL over time, and determinants of QOL in patients with indolent NHL. Methods: Newly diagnosed lymphoma patients were prospectively enrolled within 9 months of diagnosis in the University of Iowa/Mayo Clinic SPORE Molecular Epidemiology Resource. Eligibility criteria included age ≥18 years; exclusion criteria included HIV-positive, non-US residency, and inability to complete surveys in English. All pathology was reviewed by a hematopathologist. Patients with indolent B-cell NHL were included in this analysis. QOL was measured at baseline (BL) and 3 year follow-up (FU3) with the Functional Assessment of Cancer Therapy-General scale (FACT-G), which measures 4 QOL domains: physical, social/family, emotional, and functional well-being (WB), and a single item Linear Analogue Self-Assessment (LASA) for measuring overall QOL. Patients who did not complete ≥80% of FACT-G questions were excluded. Clinical data were abstracted according to a standard protocol and patients were systematically followed for events (progression, re-treatment, and death). CLL patients were excluded for event analysis due to differing definitions of outcome (progression/retreatment vs. time to first treatment). Treatment was defined as any systemic therapy (including chemotherapy, targeted agents, or antibody therapy) or radiation. QOL scores were transformed to a 0-100 scale with 100 representing the best WB or QOL for analysis. Change in QOL was assessed using the raw difference in QOL scores (i.e., FU3-BL) on the 0-100 scale with positive change scores representing improvements; minimally important difference was defined as 7 points on the transformed FACT-G subscales per previously established cutoffs (Yost and Eton, Eval & Health Prof. 2005 Jun;28:172-91). Changes in QOL from BL to FU3 were assessed using one-sample t-test of change scores vs zero. Results: 1050 patients with indolent NHL enrolled between 9/02-12/2012 and with both pre-treatment and 3 year QOL were included. QOL was collected after initiation of therapy in 215 patients (20%) and prior to therapy in 835 (80%). Subtype was 41% CLL/SLL, 32% grade 1-2 FL, 14% extranodal marginal zone, and 13% other (lymphoplasmacytic lymphoma and other). Median age was 62 years and 55% were male. At the FU3 assessment, 577 patients (55%) had received treatment, 42 (4%) transformed, and 53 (25%) had an event. Emotional WB significantly improved from BL to FU3 (mean +5.9, SD 13.3, p<0.001) while social/family WB significantly decreased (mean -4.8, SD 20.5, p<0.001). Functional WB, physical WB, overall FACT-G, and overall QOL LASA were not significantly different at FU3. These findings were similar in those who were treated vs. those who were observed. We also assessed the results stratified by non-CLL patients who had progression or retreatment between BL and FU3. In patients with an event in the first 3 years, emotional WB had a significant improvement from BL to FU3 (mean +3.6, SD 13.6, p=0.002) and overall QOL LASA decreased (mean -4.0, SD 20.0, p=0.01). In patients without an event, improvements were reported in functional WB (mean +2.1, SD 18.2, p=0.01), physical WB (mean +2.5, SD 13.9, p=0.001), emotional WB (mean +7.0, SD 15.0, p<0.001), and overall QOL LASA (mean +1.1, SD 11.4, p=0.03), while social/family WB decreased (mean -6.2, SD 20.3, p<0.001). Sensitivity analysis showed that results were consistent in the subset of patients who had BL QOL collected prior to initiating therapy. While many changes were statistically significant, they were small in magnitude; only the improvement in emotional WB in the entire cohort approached clinical significance and met that criterion in those without an event. Conclusions: In this large sample of patients with indolent lymphoma, QOL generally remained stable from diagnosis to FU3 while emotional WB showed improvement, suggesting psychosocial adaptation by the patient. Mean score changes in functional WB, physical WB, emotional WB, social/family WB, and overall QOL were more pronounced in patients without an event in the first 3 years since diagnosis. Disclosures Shanafelt: Hospira: Research Funding; AbbVie: Research Funding; Celgene: Research Funding; GlaxoSmithKline: Research Funding; Genentech: Research Funding; Jannsen: Research Funding; Pharmacyclics: Research Funding.

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Lanoye, Autumn, Amber Fox, Kelcie Willis, Alicia M. Zukas i Ashlee Loughan. "QOL-05. EXPLORATORY ANALYSIS OF COGNITIVE BEHAVIORAL THERAPY FOR INSOMNIA (CBT-I) AMONG PATIENTS WITH PRIMARY BRAIN TUMOR: EFFECTS ON DEPRESSION, ANXIETY, AND LIFE QUALITY". Neuro-Oncology 25, Supplement_5 (1.11.2023): v249. http://dx.doi.org/10.1093/neuonc/noad179.0957.

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Abstract BACKGROUND Sleep disturbance is among the most common complaints endorsed by patients with a brain tumor diagnosis, yet the delivery of behavioral insomnia treatment is not standard practice in neuro-oncology. Our pilot trial of a 6-session group-based telehealth CBT-I program among primary brain tumor patients demonstrated clinically significant improvements in self-reported insomnia, fatigue, and sleep quality. In other cancer patient samples, CBT-I is also associated with improvements in psychosocial outcomes beyond sleep; thus, the aim of this exploratory analysis was to examine change in depression, anxiety, and life quality among primary brain tumor patients enrolled in CBT-I. METHODS This was a single-arm ORBIT Model Phase IIa proof-of-concept trial. N = 40 cognitively-intact participants (Mage = 52.4 + 12 years; 50.0% female) with a primary brain tumor and insomnia enrolled in a 6-week group-based telehealth CBT-I intervention with weekly 90-minute sessions led by graduate students in clinical psychology. Questionnaires (PHQ-9, GAD-7, EORTC-QLQ-30) were completed at baseline and 6 weeks. Within-person clinically significant improvement was calculated for intervention completers (n = 34) based on established cutoffs. RESULTS Approximately one-third of participants experienced clinically significant improvements in symptoms of depression (n = 12, 35.3%) and generalized anxiety (n = 11, 32.3%) following CBT-I, with 0 participants experiencing a clinically significant worsening of symptoms. Thirty-two of thirty-four participants (94.1%) reported clinically significant improvement in at least 1 domain of life quality spanning physical, role, emotional, and/or social functioning. CONCLUSIONS Findings suggest that a brief behavioral intervention for insomnia, CBT-I, may improve depression, anxiety, and life quality in addition to sleep among primary brain tumor patients. RESULTS from this proof-of-concept trial suggest proceeding to a test of CBT-I in comparison to a control group in order to bolster internal validity. In addition, future studies will examine sleep and related psychosocial outcomes over a longer follow-up period to assess maintenance of intervention effects.

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Morrissey, Christy, Kristin Szuhany, Matteo Malgaroli, Emma Jennings, Marleen Iva Meyers, Stephen Ross, Sylvia Adams i Naomi Simon. "Fear of cancer recurrence inventory scores and their correlation with quality of life and stress levels in breast cancer survivors." Journal of Clinical Oncology 41, nr 16_suppl (1.06.2023): e24073-e24073. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.e24073.

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e24073 Background: For survivors of early stage breast cancer, the fear of cancer recurrence (FCR) can be distressing. A clinical challenge is recognizing which patients reporting FCR may need psychological intervention. Prior studies have suggested clinically significant FCR if the validated FCR Inventory (FCRI) scale score is > = 22 while others suggest as low as > = 13 may be an optimal threshold. Our goal was to understand the optimal thresholds for detection of clinically significant impairments in quality of life and high levels of stress. We thus examined FCRI thresholds that optimized detection with two standardized screening modalities of quality of life and perceived stress respectively: the Functional Assessment of Cancer Therapy-General (FACT-G) and the Perceived Stress Scale (PSS). Methods: A previously published cohort of breast cancer survivors at our institution consented to complete self-reported psychological measures and gave access to their medical records. The 2 measures being compared to the FCRI were PSS and FACT-G. FCRI, is a 9-item self-report measure, that evaluates worry about health status and illness returning, triggers that influence worry, uncertainty, and the concerns of significant others. FACT-G, a 28-item self-report measure, assesses quality of life in cancer patients, including physical well-being, social/family well-being, emotional well-being, and functional well-being; we examined the binary threshold score for reduced health related quality of life ( < = 62) vs not reduced health related quality of life (> 62). PSS, assesses the degree to which situations in one’s life are appraised as stressful; we examined the threshold score for low stress (0-13) vs moderate or high stress ( > 13). Sensitivity (Sen) and specificity (Spe) were calculated for each cutoff value for the FCRI score between 16 and 22 (two proposed cutoffs) when compared to the FACT-G and the PSS binary cut points. Results: A total of 177 breast cancer survivors participated in the study. The mean age of participants was 57.6 (SD 13.1) years. Mean scores were 18.6 (SD 7.5) for the FCRI (n = 170), 13.92 (SD 7.0) for the PSS (n = 176) and 80.6 (SD 14.9) for the FACT-G (n = 155). FCRI > = 20 appeared to optimize sensitivity and specificity both on the FACT-G (Sen: 82.4, Spe: 56.1) and PSS (Sen: 63.2 Spe: 69.1) in our patient population. Conclusions: Our results suggest that a FCRI cutoff of 20 may optimize inclusion of patients likely to have poorer quality of life and higher levels of stress. This may allow for more patients in this vulnerable population to be identified for possible intervention, without losing specificity to those with significant distress.[Table: see text]

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von Fingerhut, G., А. Meguro, К. Yu Makarov, Yu O. Kim, Е. G. Kondyurina i L. A. Yakovleva. "Effects of moderate alcohol consumption on the health of elderly Russians: a study in reference to the amount recommended to the population of Japan". JOURNAL of SIBERIAN MEDICAL SCIENCES 6, nr 2 (2022): 74–95. http://dx.doi.org/10.31549/2542-1174-2022-6-2-74-95.

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Introduction. The proportion of pure alcohol (PA) per capita in the Russian Federation (RF) is high, and moderate alcohol consumption is important for elderly Russians. In 2008, the Ministry of Health, Labor and Welfare of Japan (the Japanese are considered one of the healthiest nations in the world) recommended a daily moderate consumption of less than 20 g/day of PA. In the Russian Federation, recommendations on daily moderate alcohol consumption for elderly persons have not yet been introduced. Aim. To clarify the factors associated with the daily moderate PA consumption and its physical and social effects on the elderly people, using in reference the recommendations for the Japanese population, in order to consider the possibility of their adaptation among the Russian population. Materials and methods. A cross-sectional study was conducted among 770 elderly Russians aged 60 years and older. Methods of descriptive statistics were used to process the obtained data. Odds ratio (OR) and 95% confidence interval (CI) were calculated. A logistic regression analysis was performed, with a sample stratified by gender. Results. The logistic regression analysis among drinking participants found correlations between consumption of more than 20 g of PA per day with gender (OR = 0.582; 95% CI: 0.351–0.966), hypertension (OR = 0.384; 95% CI: 0.223–0.661), living alone (OR = 0.453; 95% CI: 0.256–0.803), the reason for alcohol intake – stress relief (OR = 4.580; 95% CI: 2.313–9.069), enjoyment of life (OR = 3.015; 95% CI : 1.207–7.531), drinking alone (OR = 2.480; 95% CI: 1.079–5.703) and with the family (OR = 2.586; 95% CI: 1.506–4.439). As a result of the stratified analysis, it was found that among male participants, alcohol consumption significantly correlated with hypertension (OR = 0.216; 95% CI: 0.090–0.521), the desire to reduce stress (OR = 2.530; 95% CI: 1.043–6.136), drinking alone (OR = 5.454; 95% CI: 1.699–17.510) and with the family (OR = 4.934; 95% CI: 2.003–12.154). Among women, alcohol consumption significantly associated with living alone (OR = 0.455; 95% CI: 0.228–0.907), the desire to reduce stress (OR = 5.274; 95% CI: 2.092–13.299), and enjoy life (OR = 4.669; 95% CI: 1.218–17.899) and drinking alcohol in the family (OR = 2.077; 95% CI: 1.069–4.033). Conclusion. The introduction of daily moderate alcohol consumption is crucial for improving the health and life expectancy of elderly Russians. However, the attempt to adapt the Japanese health policy for the Russian Federation showed no significant difference in the health characteristics of elderly people, indicating the need to introduce other possible cutoffs for daily moderate alcohol consumption. Excessive alcohol consumption occurred among Russian older people drinking alone and to relieve stress, which indicates a risk of social isolation and misunderstanding of doses for alcohol’s sedative effects. Family drinking may result in higher daily alcohol consumption among elderly people, whereas gender differences in alcohol consumption with a cutoff of 20 g per day need to be considered, especially among women. The effect of moderate alcohol consumption on hypertension requires further study.

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Sadie, Stanley, i Volkmar Braunbehrens. "Social Life". Musical Times 131, nr 1770 (sierpień 1990): 426. http://dx.doi.org/10.2307/966627.

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Oh, Daniela Eun Sun. "Social Life in Social Media". Fudan Journal of the Humanities and Social Sciences 11, nr 1 (12.07.2017): 119–22. http://dx.doi.org/10.1007/s40647-017-0186-7.

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Currivan, Douglas B., i N. Gilbert. "Researching Social Life". Teaching Sociology 22, nr 2 (kwiecień 1994): 210. http://dx.doi.org/10.2307/1318574.

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Rossano, Matt J. "Supernaturalizing Social Life". Human Nature 18, nr 3 (9.09.2007): 272–94. http://dx.doi.org/10.1007/s12110-007-9002-4.

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Jain, Ramesh, i David Sonnen. "Social Life Networks". IT Professional 13, nr 5 (wrzesień 2011): 8–11. http://dx.doi.org/10.1109/mitp.2011.86.

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Rhodius-Meester, Hanneke Frederica Maria, Sara A. J. van de Schraaf, Mike J. L. Peters, Emma E. F. Kleipool, Marijke C. Trappenburg i Majon Muller. "Mortality Risk and Its Association with Geriatric Domain Deficits in Older Outpatients: The Amsterdam Ageing Cohort". Gerontology 67, nr 2 (2021): 194–201. http://dx.doi.org/10.1159/000512048.

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<b><i>Introduction:</i></b> In older patients, life expectancy is determined by a complex interaction of multiple geriatric domains. A comprehensive geriatric assessment (CGA) captures different geriatric domains. Yet, if and how components of the CGA are related to mortality in an outpatient geriatric setting is unknown. In the Amsterdam Ageing Cohort, we therefore studied distribution and accumulation of geriatric domain deficits in relation to mortality. <b><i>Methods:</i></b> All patients received a CGA as part of standard care, independent of referral reason. We summarized deficits on the CGA, using predefined cutoffs, in 5 geriatric domains: somatic, mental, nutritional, physical, and social domain. Information on mortality was obtained from the Dutch municipal register. We used age- and sex-adjusted Cox proportional hazards analyses to relate the separate domains and accumulation of impaired domains to overall mortality. <b><i>Results:</i></b> From the 1,055 geriatric outpatients (53% female; age 79 ± 7 years), 172 patients (16%) had died after 1.7 ± 1.1 years. In 626 patients (59%), 3 or more domains were impaired. All domains were independently associated with mortality, with the highest hazard for the somatic domain (HR 3.7 [1.7–8.0]) and the lowest hazard for the mental domain (HR 1.5 [1.1–12.0]). In addition, accumulation of impaired domains showed a gradually increased mortality risk, ranging from HR 2.2 (0.8–6.1) for 2 domains to HR 9.6 (3.7–24.7) for all 5 domains impaired. <b><i>Conclusions:</i></b> This study provides evidence that impairment in multiple geriatric domains is highly prevalent and independently and cumulatively associated with mortality in an outpatient geriatric setting.

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Passias, Peter G., Samantha R. Horn, Frank A. Segreto, Cole A. Bortz, Katherine E. Pierce, Dennis Vasquez-Montes, John Moon i in. "ODI Cannot Account for All Variation in PROMIS Scores in Patients With Thoracolumbar Disorders". Global Spine Journal 10, nr 4 (9.06.2019): 399–405. http://dx.doi.org/10.1177/2192568219851478.

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Study Design: Retrospective review of single institution. Objective: To assess the relationship between Patient-Reported Outcomes Measurement Information System (PROMIS) and Oswestry Disability Index (ODI) scores in thoracolumbar patients. Methods: Included: Patients ≥18 years with a thoracolumbar spine condition (spinal stenosis, disc herniation, low back pain, disc degeneration, spondylolysis). Bivariate correlations assessed the linear relationships between ODI and PROMIS (Physical Function, Pain Intensity, and Pain Interference). Correlation cutoffs assessed patients with high and low correlation between ODI and PROMIS. Linear regression predicted the relationship of ODI to PROMIS. Results: A total of 206 patients (age 53.7 ± 16.6 years, 49.5% female) were included. ODI correlated with PROMIS Physical Function ( r = −0.763, P < .001), Pain Interference ( r = 0.800, P < .001), and Pain Intensity ( r = 0.706, P < .001). ODI strongly predicted PROMIS for Physical Function ( R2 = 0.58, P < .001), Pain Intensity ( R2 = 0.50, P < .001), and Pain Interference ( R2 = 0.64, P < .001); however, there is variability in PROMIS that ODI cannot account for. ODI questions about sitting and sleeping were weakly correlated across the 3 PROMIS domains. Linear regression showed overall ODI score as accounting for 58.3% ( R2 = 0.583) of the variance in PROMIS Physical Function, 63.9% ( R2 = 0.639) of the variance in Pain Interference score, and 49.9% ( R2 = 0.499) of the variance in Pain Intensity score. Conclusions: There is a large amount of variability with PROMIS that cannot be accounted for with ODI. ODI questions regarding walking, social life, and lifting ability correlate strongly with PROMIS while sitting, standing, and sleeping do not. These results reinforce the utility of PROMIS as a valid assessment for low back disability, while indicating the need for further evaluation of the factors responsible for variation between PROMIS and ODI.

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Taft, Tiffany H., Alyse Bedell, Meredith R. Craven, Livia Guadagnoli, Sarah Quinton i Stephen B. Hanauer. "Initial Assessment of Post-traumatic Stress in a US Cohort of Inflammatory Bowel Disease Patients". Inflammatory Bowel Diseases 25, nr 9 (7.03.2019): 1577–85. http://dx.doi.org/10.1093/ibd/izz032.

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Abstract Background Post-traumatic stress (PTS), or the psycho-physiological response to a traumatic or life-threatening event, is implicated in medical patient outcomes. Emerging evidence suggests a complex relationship between PTS, the brain–gut axis, the gut microbiome, and immune function. Inflammatory bowel disease (IBD) may be susceptible to PTS and its subsequent impacts. To date, no study has evaluated PTS in IBD in the United States. Methods Adult patients with IBD were recruited from an outpatient gastroenterology practice, via social media, and via a research recruitment website. Patients with irritable bowel syndrome (IBS) were recruited as a comparison group. Participants completed demographic and disease information, surgical and hospitalization history, and the PTSD Checklist–Civilian Version (PCL-C). Statistical analyses evaluated rates of PTS in IBD and IBS, including differences between groups for PTS severity. Regression analyses determined potential predictors of PTS. Results One hundred eighty-eight participants (131 IBD, 57 IBS) completed the study. Thirty-two percent of IBD and 26% of IBS patients met the criteria for significant PTS symptoms based on PCL-C cutoffs. Inflammatory bowel disease patients are more likely to attribute PTS to their disease than IBS patients. Crohn’s disease (CD) patients appear to be the most likely to experience PTS, including those being hospitalized or undergoing ileostomy surgery. Symptom severity is the greatest predictor of PTS for ulcerative colitis and IBS. Conclusions Although PTS is relevant in both IBS and IBD, IBD patients are seemingly more susceptible to PTS due their disease experiences, especially CD patients. The nature of PTS symptoms may contribute to IBD disease processes, most notably through sleep disturbance and ANS arousal. Clinicians should assess for PTS in IBD patients as standard of care, especially after a hospitalization or surgery.

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Lord, Brittany D., Emily Rossi, Tiffany H. Dorsey, Catherine Pichardo, William Wooten, Margaret Pichardo, Ruby Hutchison, Maeve Bailey-Whyte, Anuoluwapo Ajao i Stefan Ambs. "Abstract NG06: Investigating biological mediators of social and environmental risk factors on cancer health disparities". Cancer Research 83, nr 7_Supplement (4.04.2023): NG06. http://dx.doi.org/10.1158/1538-7445.am2023-ng06.

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Abstract Background: Chronic life stress is more prevalent in low socioeconomic status (SES) communities and has been shown to affect DNA methylation and the immune system. Yet, the biological processes that mediate the impact of SES on health to promote the development of chronic diseases like cancer remain poorly understood. Previous studies have shown that individuals from disadvantaged neighborhoods experience a disproportionate amount of both chemical and non-chemical stressors, in addition to epigenetic alterations such as histone modifications and aberrant DNA methylation, compared to those from advantaged neighborhoods. These alternations lead to differential epigenomic profiles between these socioeconomic groups which can be long lasting, even transgenerational. Our study aims to uncover if DNA methylation is linked to neighborhood socioeconomic deprivation and to a biology that causes changes to the immune microenvironment that would promote breast cancer development, progression, and reduced survival. We are specifically interested in this relationship among Black and White women with breast cancer, largely due to the 40% increased mortality that Black women experience compared to White women. Methods: DNA was extracted from 426 fresh frozen breast tissue samples from 173 Black and 116 White women in the NCI-Maryland Breast Cancer Cohort, including 185 tumor samples, 137 paired adjacent normal tissue samples, and 104 normal breast tissue samples collected from reduction mammoplasty. Using zip codes, we geocoded the locations of our study participants and linked these data to Census tract-level socioeconomic deprivation from the 2000 Census using a Neighborhood Deprivation Index (NDI). We conducted a principal component analysis (PCA) to extract a single variable that represented the shared variance across the original 20 deprivation indicators. PCA loadings about 0.25 were retained in our index including % of households in poverty, % of households on public assistance, % of households with no car, % of female headed households with dependent children, % of households earning less than $30,000 per year, and the % of males and females unemployed. Higher NDI values represented greater deprivation and lower NDI values correlated with less deprivation. The NDI was analyzed either on a continuous scale, in quartiles, or was dichotomized into high and low groups based on median cutoffs. DNA methylation data was acquired using the Illumina EPIC 850K array and a differentially methylated probe (DMP) analysis was done between tumor and paired adjacent normal tissue to identify gene regions of hypo- or hyper-methylation stratified by high and low NDI status. Additionally, using a volcano plot investigating fold change differences between NDI high and NDI low methylation beta values, we identified CpG methylation probes significantly associated with high NDI status in the tumor tissue. Finally, we used a methylCIBERSORT deconvolution analysis to estimate immune cell subpopulation differences by tissue type, race, and neighborhood deprivation status. Results: In characterizing NDI by demographic and clinical characteristics in our cohort, we found that Black participants had significantly higher NDI levels compared to White participants (p<0.0001) in both normal and tumor tissue. When considering tumor grade and molecular breast cancer subtypes, we found that higher tumor grade was significantly associated with high NDI status (p=0.0344), and higher mean NDI levels were observed in individuals with triple negative breast cancer as compared to hormone receptor positive breast cancer. From the DMP tumor versus adjacent normal paired analysis, we observed that the high neighborhood deprivation group showed more significant methylation events than the low neighborhood deprivation group, including increased hypo- and hyper-methylation in the tumor tissue compared to the adjacent normal tissue. We also found that the location of methylation changes were similar between the NDI high and low groups, with most occurring in the gene body and intergenic regions. In tumor tissue, we identified 8 hypo-methylated CpG probes that were significantly associated with high NDI status, including decreased methylation in the gene body region of two tumor suppressor genes, LRIG1 and WWOX. As methylation in the gene body of cancer cells often correlates to decreased gene expression, our results would indicate less transcriptional activity of these tumor suppressor genes in the NDI high group, potentially resulting in an increased risk of breast cancer metastasis, worse prognosis, and higher mortality. Finally, our methylCIBERSORT analysis showed decreased neutrophils in the NDI high group, which may correlate to poor response to neoadjuvant chemotherapy and more advanced stages of breast cancer. Significance: To date, little is known about how the epigenome translates neighborhood disadvantage into health disparities. Our findings show evidence of differential methylation expression in tumor and adjacent normal tissue for individuals experiencing high neighborhood deprivation, potentially translating to more adverse breast cancer outcomes for this group. This work gives mechanistic insight into how socioeconomic position may affect cancerous mammary gland biology by altering DNA methylation patterns and immune cell responses. Citation Format: Brittany D. Lord, Emily Rossi, Tiffany H. Dorsey, Catherine Pichardo, William Wooten, Margaret Pichardo, Ruby Hutchison, Maeve Bailey-Whyte, Anuoluwapo Ajao, Stefan Ambs. Investigating biological mediators of social and environmental risk factors on cancer health disparities. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr NG06.

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Schatzki, Theodore. "Materiality and Social Life". Nature and Culture 5, nr 2 (1.06.2010): 123–49. http://dx.doi.org/10.3167/nc.2010.050202.

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An important issue in contemporary social theory is how social thought can systematically take materiality into account. This article suggests that one way social theory can do so is by working with an ontology that treats materiality as part of society. The article presents one such ontology, according to which social phenomena consist in nexuses of human practices and material arrangements. This ontology (1) recognizes three ways materiality is part of social phenomena, (2) holds that most social phenomena are intercalated constellations of practices, technology, and materiality, and (3) opens up consideration of relations between practices and material arrangements. A brief practice-material history of the Kentucky Bluegrass region where the author resides illustrates the idea that social phenomena evince changing material configurations over time.

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Viegas, Marlene. "Discourse and Social Life". DELTA: Documentação de Estudos em Lingüística Teórica e Aplicada 19, nr 2 (2003): 349–53. http://dx.doi.org/10.1590/s0102-44502003000200007.

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Haines, Valerie A., i Tim Ingold. "Evolution and Social Life". Contemporary Sociology 17, nr 1 (styczeń 1988): 120. http://dx.doi.org/10.2307/2069483.

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Porteous, J. "Humor and Social Life". Philosophy East and West 39, nr 3 (lipiec 1989): 279. http://dx.doi.org/10.2307/1399449.

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Sima, Remina. "FAMILY AND SOCIAL LIFE". Gender Studies 12, nr 1 (1.12.2013): 308–18. http://dx.doi.org/10.2478/genst-2013-0019.

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Abstract The paper deals with the concept of family seen both as a system and as a unit. It shows how family functions and the structure of family. The paper also draws attention to the separation between home and work which makes substantial differences to the daily lives of both men and women. This means that there is a clear distinction between working time and leisure time, and there is a much clearer distinction between public and private life

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24

Maynard, Douglas W. "Language and Social Life". Contemporary Sociology 20, nr 6 (listopad 1991): 841. http://dx.doi.org/10.2307/2076143.

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Baldus, Bernd, i Tim Ingold. "Evolution and Social Life". Canadian Journal of Sociology / Cahiers canadiens de sociologie 14, nr 1 (1989): 117. http://dx.doi.org/10.2307/3341090.

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Subramanian, Kumaran. "Social Life in Tirukkural". Journal of Indian Studies 8, nr 1 (1.06.2003): 145–58. http://dx.doi.org/10.22452/jis.vol8no1.10.

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Seiichi, Serikawa, Yuhki Kitazono i Shota Nakashima. "Measurement in Social Life". Applied Mechanics and Materials 36 (październik 2010): 360–64. http://dx.doi.org/10.4028/www.scientific.net/amm.36.360.

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The extraction of event that cannot be detected with conventional equipment can be considered to be a precise measurement in the wide sense. In this paper, the measurement in social life is introduced. It is divided into three fields (global environment, living conditions, and life support and welfare). In each field, the method is introduced. Especially, an intelligent sensing technology is important. It is not only a measurement system for extraction of physical value, but also a system that acquires the information which human perceives and requires. The information is obtained by processing a physical value, judging, and recognizing. It is also important to examine the correlation of a physical value and a psychological value for the extraction of the information. Some examples on the study are shown. A comfortable and safe life is expected to be achieved because the measurement technology in social life advances further.

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Manstead, Antony S. R. "Emotion in social life". Cognition & Emotion 5, nr 5-6 (wrzesień 1991): 353–62. http://dx.doi.org/10.1080/02699939108411047.

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Holtan, Meghan T., Susan L. Dieterlen i William C. Sullivan. "Social Life Under Cover". Environment and Behavior 47, nr 5 (27.01.2014): 502–25. http://dx.doi.org/10.1177/0013916513518064.

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Cecil, Robert. "Commonality in Social Life". Anthropology News 38, nr 2 (luty 1997): 10. http://dx.doi.org/10.1111/an.1997.38.2.10.1.

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Sullivan, Kathleen A., i John S. Wodarski. "Life and Social Skills". Journal of Evidence-Based Social Work 3, nr 2 (25.07.2006): 67–89. http://dx.doi.org/10.1300/j394v03n02_04.

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Ellen, Roy, i Tim Ingold. "Evolution and Social Life". Man 23, nr 2 (czerwiec 1988): 413. http://dx.doi.org/10.2307/2802857.

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Hansson, Robert O. "Life-Span Social Psychology". Contemporary Psychology: A Journal of Reviews 33, nr 8 (sierpień 1988): 667–68. http://dx.doi.org/10.1037/025872.

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Lister, Adrian. "A wild social life". Nature 334, nr 6182 (sierpień 1988): 480. http://dx.doi.org/10.1038/334480a0.

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Jain, Ramesh. "Toward Social Life Networks". Computer 47, nr 11 (listopad 2014): 86–88. http://dx.doi.org/10.1109/mc.2014.336.

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Couldry, Nick. "Social Media: Human Life". Social Media + Society 1, nr 1 (29.04.2015): 205630511558033. http://dx.doi.org/10.1177/2056305115580336.

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Leitch, Alison. "The social life oflardo". Asia Pacific Journal of Anthropology 1, nr 1 (styczeń 2000): 103–18. http://dx.doi.org/10.1080/14442210010001705870.

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Jackman, Mary R. "Violence in Social Life". Annual Review of Sociology 28, nr 1 (sierpień 2002): 387–415. http://dx.doi.org/10.1146/annurev.soc.28.110601.140936.

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Verkleij, Saskia. "Late-Life Social Activity". Archives of Internal Medicine 169, nr 20 (9.11.2009): 1931. http://dx.doi.org/10.1001/archinternmed.2009.408.

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Lincoln, Yvonna, i Michael Lanford. "Life History’s Second Life". Qualitative Inquiry 25, nr 5 (14.12.2018): 464–70. http://dx.doi.org/10.1177/1077800418817835.

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New and revisited insights, theoretical developments, and the emanation of a new political landscape—coupled with the influence of new technologies and social media—suggest that life histories might be considerably more complicated to conduct today than a short generation ago. For example, at least three developments—the rise of a neoliberal, ultra-capitalist, political-economic environment; new technologies, particularly the rise of social media and the shifting social relationships such technologies have engendered; and the Enlightenment counter in posthumanism—have given rise to a postmodern “saturated self.” This “saturated self” is both more situated in the new era and, at the same time, less intimately connected with a surrounding community. This article will explore the critical junctures and concussions of life history with new theoretical, political, and social pressures on the individual and on the practice of creating biography from life history.

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Manning, Peter K. "Drama = Life?:The Drama of Social Life: Essays in Post-Modern Social Psychology". Symbolic Interaction 16, nr 1 (luty 1993): 85–89. http://dx.doi.org/10.1525/si.1993.16.1.85.

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RUBINSTEIN, W. D. "SOCIAL CLASS, SOCIAL ATTITUDES, AND BRITISH BUSINESS LIFE". Oxford Review of Economic Policy 4, nr 1 (1988): 51–58. http://dx.doi.org/10.1093/oxrep/4.1.51.

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Hay, Dale F., Patricia Murray, Sylvia Cecire i Alison Nash. "Social Learning of Social Behavior in Early Life". Child Development 56, nr 1 (luty 1985): 43. http://dx.doi.org/10.2307/1130172.

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Bao, Wan-Ning, Ain Haas i Yunping Xie. "Life Strain, Social Control, Social Learning, and Delinquency". International Journal of Offender Therapy and Comparative Criminology 60, nr 12 (6.04.2015): 1446–69. http://dx.doi.org/10.1177/0306624x15577162.

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Kohli, Martin, i John W. Meyer. "Social Structure and Social Construction of Life Stages". Human Development 29, nr 3 (1986): 145–80. http://dx.doi.org/10.1159/000273038.

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Buunk, Abraham P., Hinke A. K. Groothof i Frans W. Siero. "Social comparison and satisfaction with one's social life". Journal of Social and Personal Relationships 24, nr 2 (kwiecień 2007): 197–205. http://dx.doi.org/10.1177/0265407507075410.

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Deindl, Christian, Martina Brandt i Karsten Hank. "Social Networks, Social Cohesion, and Later-Life Health". Social Indicators Research 126, nr 3 (1.03.2015): 1175–87. http://dx.doi.org/10.1007/s11205-015-0926-5.

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Ablow, Rachel. "The Social Life of Pain". Representations 146, nr 1 (2019): 1–9. http://dx.doi.org/10.1525/rep.2019.146.1.1.

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Karlsson, Bengt G. "The social life of categories". Focaal 2013, nr 65 (1.03.2013): 33–41. http://dx.doi.org/10.3167/fcl.2013.650104.

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In this article I examine the ways in which the term “indigenous peoples“ is reworked in a specific South Asian context. I focus on the new, hybrid category of “indigenous tribe“ in the Indian state of Meghalaya. I argue that we can think of the indigenous tribe category as a strategic conflation of two different regimes of rights or political assertions. The first relates to the existing nation-state framework for affirmative action as expressed in the Scheduled Tribe (ST) status, while the second relates to the emerging global framework for asserting the rights of indigenous peoples. While the benefits of asserting the status of indigenous tribes is obvious, for example, preventing other, nonindigenous tribes from owning land in the state, the long-term gains seems more doubtful. Both affirmative action programs and indigenous peoples frameworks are motivated by a moral imperative to redress historical injustices and contemporary social inequalities. To evoke them for other ends might eventually backfire. The larger point I seek to make, however, is that political categories tend to take on a life of their own, escaping their intended purposes and hence applied by people in novel and surprising ways.

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Noonan, Jeffrey. "Life Value and Social Justice". Studies in Social Justice 5, nr 1 (21.07.2011): 1–10. http://dx.doi.org/10.26522/ssj.v5i1.990.

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