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Artykuły w czasopismach na temat "Shifting nitroxides"
Audran, Gérard, Lionel Bosco, Paul Brémond, Jean‐Michel Franconi, Neha Koonjoo, Sylvain R. A. Marque, Philippe Massot, Philippe Mellet, Elodie Parzy i Eric Thiaudière. "Enzymatically Shifting Nitroxides for EPR Spectroscopy and Overhauser‐Enhanced Magnetic Resonance Imaging". Angewandte Chemie International Edition 54, nr 45 (2.11.2015): 13379–84. http://dx.doi.org/10.1002/anie.201506267.
Pełny tekst źródłaAudran, Gérard, Lionel Bosco, Paul Brémond, Jean‐Michel Franconi, Neha Koonjoo, Sylvain R. A. Marque, Philippe Massot, Philippe Mellet, Elodie Parzy i Eric Thiaudière. "Enzymatically Shifting Nitroxides for EPR Spectroscopy and Overhauser‐Enhanced Magnetic Resonance Imaging". Angewandte Chemie 127, nr 45 (17.09.2015): 13577–82. http://dx.doi.org/10.1002/ange.201506267.
Pełny tekst źródłaAudran, Gérard, Samuel Jacoutot, Natacha Jugniot, Sylvain R. A. Marque i Philippe Mellet. "Shifting-Nitroxides to Investigate Enzymatic Hydrolysis of Fatty Acids by Lipases Using Electron Paramagnetic Resonance in Turbid Media". Analytical Chemistry 91, nr 9 (23.04.2019): 5504–7. http://dx.doi.org/10.1021/acs.analchem.9b00561.
Pełny tekst źródłaAudran, Gérard, Samuel Jacoutot, Natacha Jugniot, Sylvain R. A. Marque i Philippe Mellet. "Correction to Shifting-Nitroxides to Investigate Enzymatic Hydrolysis of Fatty Acids by Lipases Using Electron Paramagnetic Resonance in Turbid Media". Analytical Chemistry 92, nr 11 (18.05.2020): 7987. http://dx.doi.org/10.1021/acs.analchem.0c01833.
Pełny tekst źródłaHui, Pramiti, i Rajadurai Chandrasekar. "Shape-Defined and Shape-Shifting Paramagnetic Organic Nano/Microstructures Derived From a Doublet State Nitronyl Nitroxide Radical". ChemPlusChem 77, nr 12 (31.07.2012): 1062–65. http://dx.doi.org/10.1002/cplu.201200143.
Pełny tekst źródłaJugniot, Natacha, Indranil Duttagupta, Angélique Rivot, Philippe Massot, Colleen Cardiet, Anne Pizzoccaro, Marion Jean i in. "An elastase activity reporter for Electronic Paramagnetic Resonance (EPR) and Overhauser-enhanced Magnetic Resonance Imaging (OMRI) as a line-shifting nitroxide". Free Radical Biology and Medicine 126 (październik 2018): 101–12. http://dx.doi.org/10.1016/j.freeradbiomed.2018.08.006.
Pełny tekst źródłaHui, Pramiti, i Rajadurai Chandrasekar. "Cover Picture: Shape-Defined and Shape-Shifting Paramagnetic Organic Nano/Microstructures Derived From a Doublet State Nitronyl Nitroxide Radical (ChemPlusChem 12/2012)". ChemPlusChem 77, nr 12 (grudzień 2012): 1051. http://dx.doi.org/10.1002/cplu.201290051.
Pełny tekst źródłaRozprawy doktorskie na temat "Shifting nitroxides"
Jacoutot, Samuel. "Synthèse de sondes nitroxydes pour la détection de l’activité enzymatique : application à la spectroscopie par RPE et à l'IRM rehaussée par effet Overhauser". Electronic Thesis or Diss., Aix-Marseille, 2020. http://www.theses.fr/2020AIXM0489.
Pełny tekst źródłaThis work presents the synthesis of new radical probes to investigate enzymatic activity. Those probes, named “shifting nitroxides”, are synthesized to develop new methods for the detection of enzymatic activity using EPR, but also for an application in diagnosis by OMRI. The shifing nitroxides could then be an efficient alternative to the gadolinium based contrast agents. The first part focused on the optimization of the synthesis of the free shifting nitroxyde, a key synthetic intermediate. The yield has been improved from 2 to 13 % over ten synthetic steps. The second part is devoted to the synthesis of several nitroxides based probes from the free shifting nitroxide. Thus, this manuscript describes the synthesis of nitroxydes suitable for the detection of lipases by EPR spectroscopy. Other probes have been synthesized for the early detection of pulmonary inflammations: one is currently used for the development of earth’s magnetic field MRI, and the other has been used to develop the first example of in vivo detection of a disease by OMRI. Finally, the synthesis of the first family of shifting nitroxydes recognized by UPA is also described. These probes are then promising for the early diagnosis of cancers using OMRI
Jugniot, Natacha. "Molecular imaging of serine protease activity-driven pathologies by magnetic resonance". Thesis, Bordeaux, 2019. http://www.theses.fr/2019BORD0141/document.
Pełny tekst źródłaThis work focuses on substrate-based probes for proteolysis monitoring by Electron Paramagnetic Resonance spectroscopy (EPR) and for in vivo imaging by Overhauser-enhanced Magnetic Resonance (OMRI). More precisely, this work investigates for the first time a family of MRI agents named “line-shifting nitroxide” specific for proteolytic activities. Proteolytic action results in a shift of 5 G in EPR hyperfine coupling constants allowing individual quantification of substrate and product species by EPR and selective excitation by OMRI. Three substrates were worked out, showing enzymatic specificity for neutrophil elastase (MeO-Suc-Ala-Ala-Pro-Val-Nitroxide & Suc-Ala-Ala-Pro-Val-Nitroxide), and for Chymotrypsin/Cathepsin G (Suc-Ala-Ala-Pro-Phe-Nitroxide). Enzymatic constants were remarkably good with globally Km = 28 ± 25 µM and kcat = 19 ± 3 s-1. Ex vivo, the use of NE substrates in OMRI revealed a high contrast in bronchoalveolar lavages of mice under inflammatory stimulus. MRI signal enhancements correlate with the severity of inflammation. Irradiation at the RPE frequency of 5425.6 MHz provided access to the bio-distribution of substrates in vivo and could thus serve as a diagnostic tool. The medium-term perspectives of this work are based on the development of OMRI with very low magnetic fields for human application