Rozprawy doktorskie na temat „Serotonin”
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Edgar, Christopher James. "Serotonin and attention". Thesis, Northumbria University, 2007. http://nrl.northumbria.ac.uk/2896/.
Pełny tekst źródłaWang, Chung-Chi. "Regulation of hepatic glucose metabolism by serotonin and serotonin receptor agonists". Thesis, University of Newcastle Upon Tyne, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.578261.
Pełny tekst źródłaLecours, Maurice. "Electrophysiological Investigations on the Role of Selected Serotonin Receptors and the Serotonin Transporter on Serotonin Transmission in the Rat Brain". Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/30400.
Pełny tekst źródłaParrish, Leslie. "Love and Low Serotonin". TopSCHOLAR®, 2008. http://digitalcommons.wku.edu/theses/371.
Pełny tekst źródłaSelvaraj, Sudhaker. "Serotonin transporters in depression". Thesis, University of Oxford, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.540258.
Pełny tekst źródłaHeath, D. G. "Triazolopyridines as serotonin analogues". Thesis, Imperial College London, 1985. http://hdl.handle.net/10044/1/37721.
Pełny tekst źródłaPorter, Richard J. "Corticosteroid serotonin interactions in depression". Thesis, University of Newcastle upon Tyne, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.289200.
Pełny tekst źródłaStuart, E. "Biochemical studies on serotonin receptors". Thesis, University of Nottingham, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.372014.
Pełny tekst źródłaSchaechter, Judith Diane. "Tryptophan availability modulates serotonin release". Thesis, Massachusetts Institute of Technology, 1989. http://hdl.handle.net/1721.1/13995.
Pełny tekst źródłaGustafson, Megan Alyse. "Serotonin signaling in C. elegans". Thesis, Massachusetts Institute of Technology, 2007. http://hdl.handle.net/1721.1/40957.
Pełny tekst źródłaIncludes bibliographical references.
Wild-type animals that have been acutely food deprived slow their locomotory rate upon encountering bacteria more than do well-fed animals. This behavior, called the enhanced slowing response, is partly serotonin (5-HT) dependent. Animals mutant for the 5-HT reuptake transporter gene mod-5 slow even more than wild-type animals because endogenous 5-HT activity is potentiated. This behavior, called the hyperenhanced slowing response, can be suppressed by mutations in genes that encode proteins important for 5-HT signaling, like the 5-HT receptor encoded by mod-1 and the Ga subunit of a G protein encoded by goa-1. This ability to suppress indicates that these genes likely act downstream of or in parallel to one or more 5-HT synapse(s) that mediate(s) the enhanced slowing response. To find genes that play a role in 5-HT signaling, we screened for suppressors of the 5-HT hypersensitivity of mod-5. We found at least seven alleles of goa-i and at least two alleles of mod-1. This shows that our screen is able to target genes that play a role in endogenous 5-HT signaling. We identified two alleles of the FMRFamide-encoding gene fp-1, which was known to mediate paralysis in exogenous 5-HT. We showed that loss-of-function mutations in flp-1 confer an enhanced slowing response defect. We also identified an allele of abts-1, which encodes a bicarbonate transporter, and showed that it has defects in cholinergic signaling. We identified three mutants that show linkage to LG I, four to II, three to V and one to X, most of which display defects consistent with a role in 5-HT signaling.
(cont.) We used a candidate gene approach to find that deletions in ser-4, which encodes a metabotropic 5-HT receptor, confer 5-HT resistance. ser-4 acts redundantly with the ionotropic 5-HT receptor mod-1 to suppress the hyperenhanced slowing response of mod-5. Our genetic analysis suggests that ser-4 acts in a pathway with goa-1, in parallel to mod-1. We found that the enhanced slowing response defect of flp-1 is primarily due to its defect in transmitting a 5-HT signal and that flp-1 likely acts downstream of ser-4 and mod-1.
by Megan Alyse Gustafson.
Ph.D.
Gharat, Laxmikant Atmaram. "Chemical studies on serotonin analogs". Diss., The University of Arizona, 1996. http://hdl.handle.net/10150/187502.
Pełny tekst źródłaChang, Karin. "Platelets and Serotonin in Migraine". University of Toledo Health Science Campus / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=mco1279586929.
Pełny tekst źródłaKillam, Anne Louise. "Characterization of vascular serotonin receptors". Diss., The University of Arizona, 1990. http://hdl.handle.net/10150/184995.
Pełny tekst źródłaHarkin, Emerson. "A Simplified Serotonin Neuron Model". Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/38533.
Pełny tekst źródłaChee, Francis Craig. "Expression of Serotonin in the Development of Patiriella species (Echinodermata: Asteroidea) with Different Modes of Development". Thesis, The University of Sydney, 2000. https://hdl.handle.net/2123/24561.
Pełny tekst źródłaTAYLOR, ETHAN WILL. "THE DEVELOPMENT OF INDOLEAMINE DERIVATIVES SELECTIVE FOR SUBTYPES OF SEROTONIN RECEPTORS (TRYPTAMINE, BASILAR ARTERY, ANTAGONIST, ERGOLINE, SYNTHESIS)". Diss., The University of Arizona, 1985. http://hdl.handle.net/10150/188104.
Pełny tekst źródłaRami, Martina [Verfasser], i Sabine [Akademischer Betreuer] Steffens. "Role of serotonin and antidepressants targeting serotonin transporters in atherosclerosis / Martina Rami ; Betreuer: Sabine Steffens". München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2018. http://d-nb.info/1175381616/34.
Pełny tekst źródłaHamdan, Fadi F. "Serotonin biosynthesis and receptors in helminths". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0035/NQ64571.pdf.
Pełny tekst źródłaBhagwagar, Zubin. "Serotonin, cortisol and vulnerability to depression". Thesis, University of Oxford, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.410616.
Pełny tekst źródłaShaikh, S. "Serotonin and the rat adrenal gland". Thesis, University of Edinburgh, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.383007.
Pełny tekst źródłaLima, João. "Serotonin transporter function and emotional behaviour". Thesis, University of Oxford, 2017. http://ora.ox.ac.uk/objects/uuid:ea4aa369-26e1-482a-9950-e027acca6f44.
Pełny tekst źródłaSeibel, Yasmine. "The Role of Serotonin in Atherosclerosis". Doctoral thesis, Humboldt-Universität zu Berlin, 2020. http://dx.doi.org/10.18452/21818.
Pełny tekst źródłaAtherosclerosis is a common disease and its pathogenesis is only poorly understood. It’s known that external and internal factors play a role, but the exact processes need to be investigated more intensively to develop novel therapy approaches. As an all-round talent, serotonin (5-HT) might be a promising candidate to play a crucial role in atherosclerosis. If and how 5-HT affects atherosclerotic plaque formation, macrophage invasion, calcification and fibrosis was focus of this study. This study is the first of its kind using the novel approach of transgenic double knockout mice lacking the apolipoprotein E (ApoE, atherosclerosis model) and either the key enzyme in peripheral 5-HT synthesis, tryptophan hydroxylase 1 (Tph1) or the major 5-HT transporter, SERT. Physiology, metabolic parameters and atherogenic processes in ApoE/Tph1-/- and ApoE/Sert-/- animals were examined using a broad spectrum of methods and resulted in an extensive overview of how 5-HT might influence the pathogenesis of atherosclerosis. Most striking results of this study: 5-HT receptor distribution is altered in vessels of different background strains, and also in Tph1 deficient animals generated in these strains. Further, the examination of ApoE/Tph1-/- and ApoE/Sert-/- mice elucidated that both double knockouts exhibit different phenotypes: While Tph1 deficiency resulted in decreased bodyweight, plasma cholesterol and liver parameters and increased liver weight, Sert deficiency caused increases in blood glucose, plasma cholesterol, plaque size and collagen in plaques. Long term Western Diet application confirmed that Tph1 deficiency decreases weight gain and has protective effects on lipid metabolism, but a clear effect on atherogenesis could not be reported. Concluding, this study highlights the complex relationship between many factors acting on atherosclerotic pathogenesis. 5-HT plays a role in many of those factors, but seems to have only minor but protective effects on atherogenesis itself.
Bourdon, David Milon. "Serotonin receptors in mammalian salivary glands /". free to MU campus, to others for purchase, 2001. http://wwwlib.umi.com/cr/mo/fullcit?p3012950.
Pełny tekst źródłaBourdon, David M. "Serotonin receptors in mammalian salivary glands". free to MU campus, to others for purchase, 2001. http://wwwlib.umi.com/cr/mo/fullcit?p3012950.
Pełny tekst źródłaCorchs, Felipe D\'Alessandro Ferreira. "Serotonina e sensibilidade a estímulos relacionados ao trauma no transtorno de estresse pós-traumático remitido com inibidores seletivos de recaptura de serotonina". Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/5/5142/tde-24032009-171403/.
Pełny tekst źródłaINTRODUCTION: Although Selective Serotonin Reuptake Inhibitors (SSRIs) are the first-line Posttraumatic Stress Disorder (PTSD) treatments their mechanism of action is unclear, but possibly improvement of stress resilience is involved. As serotonin (5HT) helps regulate stress responses in other anxiety disorders, the acute tryptophan depletion (aTD) technique was used to lower brain 5HT in SSRSs-remitted PTSD patients. METHODS: Ten patients with PTSD (Mini-International Neuropsychiatric Interview diagnosed) who had made a full recovery on SSRIs (Clinical Global Impressions Improvement Scale 1-2 for at least 3 months) were enrolled in the experiment. Patients were tested on 2 separate occasions a week apart - each session they received a drink containing large neutral amino acids either with (Sham Depletion [SD]; control day) or no tryptophan (aTD day). Self reports of anxiety and mood, as well as cardiovascular measures, were obtained throughout the tests. At 5.5 hours after the drink subjects were reexposed to their trauma using a modification of Pitmans imagery guided method. RESULTS: These procedures provoked elevated ratings on both days, with significantly more marked responses on the aTD day according to Visual Analogue Scales (aTD 47.57 [21.75] -v- SD 20.71 [18.4]; p=0.006), Davidson Trauma Scale (29.4 [12.7] -v- 15.7 [7.79]; p=0.001), Spielberger State Anxiety Inventory (28.9 [11.03] -v- 18.5 [10.13]; p=0.066, and Profile of Mood States (p<0.001). CONCLUSIONS: These data are the first to show that 5HT depletion worsens the subjective responses to reliving traumatic memories in PTSD and suggest that that SSRI-induced increases in 5HT function restrains PTSD symptoms, especially under provocation, i.e. 5HT helps mediate resilience to stress. As well as giving insights into how SSRIs work in PTSD, these data may also offer a translational approach to potential new treatments for this disorder
Borg, Jacqueline. "Molecular imaging of the serotonin system in human behaviour /". Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-134-0/.
Pełny tekst źródłaYan, Hongmei. "Stereoselective transport of drugs across the blood-brain barrier (BBB) in vivo and in vitro : pharmacokinetic and pharmacodynamic studies of the (S)- and (R)-enantiomers of different 5-HT₁A receptor agonists and antagonists /". Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2002. http://publications.uu.se/theses/91-554-5280-9/.
Pełny tekst źródłaAlbinsson, Agneta. "Serotonin receptors in the regulation of prolactin release and some behaviors in the rat". Lund : Dept. of Zoophysiology, University of Lund, 1995. http://catalog.hathitrust.org/api/volumes/oclc/38865664.html.
Pełny tekst źródłaMendelson, Scott Douglas. "Differential roles of serotonin receptor subtypes in the modulation of lordosis behaviour in the female rat". Thesis, University of British Columbia, 1988. http://hdl.handle.net/2429/29021.
Pełny tekst źródłaArts, Faculty of
Psychology, Department of
Graduate
Liwicki, Gemma Michele. "The design and synthesis of 5-HT₁B receptor antagonists". Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608202.
Pełny tekst źródłaHarrison, Amanda Ann. "The functional organisation of forebrain serotonin systems". Thesis, University of Cambridge, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.263007.
Pełny tekst źródłaRanganathan, Rajesh 1971. "Serotonin-dependent modulation of Caenorthabditis elegans behaviors". Thesis, Massachusetts Institute of Technology, 2001. http://hdl.handle.net/1721.1/80640.
Pełny tekst źródłaAbdul, Hussein Saba. "Conformational thermostabilisation of a mammalian serotonin transporter". Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609601.
Pełny tekst źródłaAlattas, Noor Abdulrahman S. "Polysaccharide-mediated formation of pigments from serotonin". Thesis, Tennessee State University, 2016. http://pqdtopen.proquest.com/#viewpdf?dispub=10119066.
Pełny tekst źródłaAs a continuation of the research on the pigment formation from catecholamines, we studied the polysaccharide-mediated oxidation of serotonin and other 5-hydroxy indoles into pigmented substances. As for catecholamines, we observed that many polysaccharides promote the oxidation of such compounds, particularly in the presence of Cu (II). The same polysaccharides, e.g., carrageenan or fucoidan, which strongly promoted the oxidation of catecholamines, strongly promoted the oxidation of serotonin, leading to the formation of darkly colored pigments. The reactions were evaluated using RP-HPLC and size exclusion chromatography (SEC) as the main analytical techniques. SEC proved particularly informative as these analyses allowed us to monitor (1) the decline in the substrate, (2) the formation of low-molecular mass oxidation products, (3) the formation of polysaccharide-associated pigments, and (4) the formation of potential pigment-based nanoparticles. We observed that increased amounts of polysaccharide or Cu (II) increased the amount of pigment generated. However, other cations like Co(II), Ni(II), Mn(II), or Fe(II) had no or very little effect on the reactivity. Apart from serotonin, 5-hydroxy indole could serve as a substrate to generate polysaccharide-associated pigments. However, reactions with the related substrate, 5-hydroxy indole-3-acetic acid yielded a low molecular mass chromophore, but not any polysaccharide-associated pigments. Large-scale reactions were set up in an attempt to isolate and characterize any pigments that were generated. The reaction mixtures could readily be dialyzed and lyophilized to obtain polysaccharide-associated pigments. Pigments were evaluated using UV-Vis spectroscopy, SEC analysis, FT_IR spectroscopy, and atomic absorption spectroscopy to evaluate the amount of Cu remaining in the materials.
Gow, Iain Frederick. "Development and application of assays for serotonin". Thesis, University of Edinburgh, 1987. http://hdl.handle.net/1842/18918.
Pełny tekst źródłaDe, La Fuente Barrigon C. "Dopamine and serotonin metabolism in Parkinsonian models". Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10054116/.
Pełny tekst źródłaOrdway, Gregory A. "The Inextricable Relationship Between Serotonin and Norepinephrine". Digital Commons @ East Tennessee State University, 2005. https://dc.etsu.edu/etsu-works/8664.
Pełny tekst źródłaQuested, Digby John. "Serotonin receptor mechanisms in anti-depressant action". Master's thesis, University of Cape Town, 2003. http://hdl.handle.net/11427/12577.
Pełny tekst źródłaSerotonin neurones have been implicated in the pathophysiology and treatment of clinical depression to a greater degree than any other neurotransmitter. Additionally, serotonin pathways may playa role in the pathophysiology and treatment of eating disorders, anxiety states and schizophrenia. Molecular biological studies have confirmed pharmacological evidence suggesting the existence of multiple serotonin receptor subtypes and the genes for these receptors, as well as that of the serotonin transporter, have common polymorphic variants. To investigate the effect of repeated treatment with selective serotonin fe-uptake inhibitors (SSRI's) on the function of central 5-HT2C receptors. To assess the effect of polymorphic variation in the 5-HT2c receptor and serotonin transporter on functional responses to selective pharmacological challenge. To determine whether polymorphic variation in the 5-HT receptor and serotonin transporter influence the clinical response of patients with major depression to treatment with serotonergic antidepressants. To assess the effect of repeated treatment with selective serotonin re-uptake inhibitors (SSRI's) on the function of central 5-HT2c receptors I used the 5-HT2C receptor agonist, m-chlorophenylpiperazine (m-CPP) as a 5-HT2c probe in a neuroendocrine challenge paradigm. I used the same approach to assess whether polymorphic variation in the 5-HT2c receptor (serine vs cysteine substitution) was associated with differences in functional response to 5-HT2C receptor challenge. I then studied whether polymorphic variation in the serotonin transporter promotor region (long versus short form) was associated with differing functional responses to acute challenge with clomipramine, a tricyclic antidepressant with a high affinity for the serotonin transporter. Finally, I studied whether either of these polymorphic variants influenced the clinical response of patients with major depression to treatment with SSRI's and clomipramine. SSRI treatment significantly lowered the sensitivity of 5-HT2c receptors as predicted from animal experimental studies. However polymorphic variation in the 5-HTzc receptor did not significantly influence functional responses to m-CPP challenge. In contrast polymorphic variation in the serotonin transporter was associated with differing neuroendocrine responses to acute clomipramine challenge with greater prolactin release being seen in subjects with the long polymorphic variant. Neither the 5-HTzc nor the transporter polymorphisms correlated with clinical response to SSRI and clomipramine treatment in patients with major depression. The ability of SSRI's to produce a functional down-regulation of 5-HTzc receptors may be relevant to certain of their therapeutic effects. Polymorphic variation in the 5-HT2c receptor (serine vs cysteine) seems unlikely to explain functional differences in responses to 5-HTzc receptor challenge or antidepressant responses to SSRI treatment. In contrast variation in the serotonin transporter promotor is associated with differing functional responses to acute serotonin re-uptake blockade. However, this did not correlate with clinical response to longer-term SSRI treatment.
Rasmussen, Fredrika. "The role of serotonin in animal personality". Thesis, Linköpings universitet, Biologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-138154.
Pełny tekst źródłaKolodziejczak, Marta. "Serotonin & developmental axonal refinement : microglia contribution ?" Thesis, Paris 6, 2015. http://www.theses.fr/2015PA066073/document.
Pełny tekst źródłaSerotonin, besides its functions as a neurotransmitter, actively participates in postnatal establishment and refinement of brain wiring in mammals. Another important role is played by the brain resident macrophages, microglia, in developmentally-regulated neuronal death as well as in synaptic maturation or elimination.During my thesis, I tested the hypothesis of cross-regulations between microglia and serotonin during postnatal brain development in a mouse model. The laboratory data show a major expression of the serotonin 5-HT2B receptor by postnatal microglia, suggesting that serotonin could participate in temporal and spatial synchronization of microglial functions. Using an in vivo model of synaptic refinement during early brain development, the maturation of retinal projections to the thalamus, I observed that Htr2B-/- mice present anatomical alterations of the projecting area of retinal axons into the thalamus.Parallelly, I tested the effects of serotonin on microglial cells. A local delivery of serotonin attracted microglial processes on acute brain slices (two-photon microscopy).Moreover, after comparing mRNA expression level in microglial primary cultures, we have found that some activation markers are upregulated in microglia from Htr2B-/-.In the second part of my PhD, by using a number of conditional Htr2B-/- mice, I investigated which cell type(s) could be responsible for the altered segregation of retinal axons in the thalamus of the total Htr2B-/- mice.Overall, my results support the hypothesis that serotonin interacts with microglial cells and that these interactions could participate in brain maturation
Hiroi, Ryoko. "Effects of estrogen and serotonin on anxiety /". Thesis, Connect to this title online; UW restricted, 2008. http://hdl.handle.net/1773/9124.
Pełny tekst źródłaZarpellon, Alessandro. "Platelet interactions with a-thrombin and serotonin". Doctoral thesis, Università degli studi di Padova, 2008. http://hdl.handle.net/11577/3425112.
Pełny tekst źródłaLüttgen, Maria. "Serotonergic receptor subtypes in learning and memory : focus on 5-HT1A, 5-HT1B and 5-HT2A receptors /". Stockholm, 2004. http://diss.kib.ki.se/2004/91-628-6148-4/.
Pełny tekst źródłaPatocka, Nicholas. "Identification of a serotonin transporter and serotonin receptor in «Schistosoma mansoni»: a step towards better understanding the serotonergic system". Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=114120.
Pełny tekst źródłaParmi la liste du haut des maladies tropicales négligées est assis la schistosomiase, une maladie parasitaire causée par le Schistosoma. La maladie implique un mollusque intermédiaires et hôte définitif de l'homme avec une infection en cours à travers la peau dans l'eau contaminée, l'une des raisons de sa large diffusion. La diversité des étapes du cycle de vie et de la capacité du parasite à avoir adapté à des environnements très différents parlent de la complexité de l'organisme. Le système sous-jacent qui coordonne et contrôle toutes les fonctions biologiques du parasite est son système nerveux. Signalisation dans le système nerveux est accompli par la libération des neurotransmetteurs et transduction du signal par récepteurs spécifiques. Parmi des nombreux neurotransmetteurs identifiés jusqu'à présent dans le parasite, la sérotonine (5-hydroxytryptamine : 5-HT) est l'un des plus abondants. 5HT a été impliqué dans plusieurs fonctions biologiques dans les vers plats, notamment contraction musculaire, la motilité et le métabolisme, mais son mode d'action est mal comprise. Ici nous fournir preuve moléculaire d'une transporteur de la sérotonine spécifique (SERT) au Schistosoma mansoni ainsi qu'un récepteur de la sérotonine spécifique dans le même organisme. Le transporteur (SmSERT) a été montré à partager la même topologie à SERT provenant d'autres organismes, à savoir 12 régions transmembranaire avec plusieurs sites de glycosylation prédits. Dans une expression hétérologue système, nous montrons qu'il négocie l'absorption de la sérotonine de manière dose-dépendante et est sensible aux inhibiteurs de SERT classiques. Le transporteur est exprimé dans toutes les étapes du cycle de vie testé (cercaria, schistosomula et adulte) avec regulation à la hausse survenant dans les stades parasitaires. Études immunolocalisation ont montré que la protéine est exprimée principalement dans le système nerveux du parasite, à la fois central et périphérique dans les structures neuronales. L'interférence ARN (ARNi) de rabattement d'expression, nous avons trouvé une forte augmentation de la motilité, suggérant que sa fonction principale est en cessation de signalisation de la sérotonine. Le récepteur de la sérotonine (Sm5htr) est le premier en tant que telle cloné à partir de vers plats parasitaires. Il partage homologie avec d'autres récepteurs 5HT et plus étroitement s'identifie à la classe des récepteurs 5-HT7. Expression dans des cellules de mammifères a constaté qu'il signale une regulation positive de l'AMPc et non de Ca2+. Immunolocalisation chez les adultes et les larves découvert que le récepteur est enrichi dans le système nerveux central et périphérique. D'autres essais pharmacologiques utilisant des agonistes et antagonistes suggèrent que le récepteur peut contribuer à la stimulation de la motilité du ver induite par la 5HT. Ensemble, ces résultats montrent qu'il existe un système sérotoninergique pleinement fonctionnel dans le parasite S. mansoni et que ces protéines jouent un rôle important dans le contrôle transduction du signal. La large diffusion de ces protéines dans le parasite système nerveux et leur implication apparente de commande de moteur fait d'eux des cibles tentantes dans la conception des médicaments.
Traxler, Claudia [Verfasser], i Stefan [Gutachter] Unterecker. "Untersuchung serumpiegelabhängiger unerwünschter Arzneimittelwirkungen von selektiven Serotonin-Rückaufnahme-Inhibitoren sowie Serotonin-Noradrenalin-Rückaufnahme-Inhibitoren / Claudia Traxler ; Gutachter: Stefan Unterecker". Würzburg : Universität Würzburg, 2021. http://d-nb.info/1232647705/34.
Pełny tekst źródłaKalkowski, Andreas. "Serotonin und seine lichtähnliche Wirkung im circadianen System der Ratte". [S.l. : s.n.], 2000. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB8862169.
Pełny tekst źródłaManrique, Muñante Rubén. "Love: there is (bio)chemistry between us". Revista de Química, 2014. http://repositorio.pucp.edu.pe/index/handle/123456789/99292.
Pełny tekst źródłaRomantic love involves biochemical processes in which substances such as neurotransmitters, neuromodulators and hormones interact with other nerve cells or organs. When being in love, dopamine levels increases, generating attention, desire and motivation in everything related to the beloved person. Serotonin, however, is present in low levels in this state. When the body does not supply the necessary amount of dopamine, oxytocin is released. Oxytocin is vital in long term relationships. Understanding the mechanism of oxytocin in humans is crucial not only for academic knowledge of the chemistry of love but also because it provides new lights for the treatment of some psychological disorders.
Soares, Joacil Germano. "Delimita??o dos grupamentos serotonin?rgicos/n?cleos da rafe do moc? (kerodon rupestris): citoarquitetura e imunoistoqu?mica para serotonina". Universidade Federal do Rio Grande do Norte, 2010. http://repositorio.ufrn.br:8080/jspui/handle/123456789/17308.
Pełny tekst źródłaSerotonin or 5-hydroxytryptamine (5-HT) is a substance found in many tissues of the body, including as a neurotransmitter in the nervous system, in which may exert varied post-synaptic actions. Inside the neuro-axis, the location of 5-HT neurons is almost restricted to the raphe nuclei of the brainstem, such that 5-HT-immunoreactivity can be considered a marker of the raphe nuclei. The raphe nuclei are located in the brainstem, at or near the midline. The serotonergic groups were originally alphanumerically classified as B1 to B9 towards caudorrostral in rats and can be divided into upper and lower groups. In this study the distribution of serotonergic neurons was studied using immunohistochemistry in the brain of the rock cavy (Kerodon rupestris), a species of rodent endemic to Northeastern Brazil. The cytoarchitectonic location of serotonergic neurons was established in series of adjacent coronal and sagittal sections stained by the Nissl method and immunohistochemistry for 5-HT. Thus, we defined the raphe rostral linear, caudal linear, dorsal, median, and paramedian pontine raphe nuclei, and B9 cluster, constituting the rostral group, and the interpositus, magnus, obscure and palidus, constituting the caudal part of the group, comparable to which has been described for other mammalian species
A serotonina ou 5-hidroxitriptamina (5-HT) ? uma subst?ncia encontrada em muitos tecidos do organismo, inclusive no sistema nervoso como neurotransmissor, onde pode exercer a??es p?s-sin?pticas variadas. Dentro do neuro-eixo, a localiza??o dos neur?nios 5-HT ? quase absoluta nos n?cleos da rafe do tronco encef?lico, de tal maneira que 5-HT neuronal pode ser considerada um marcador dos n?cleos da rafe. Os n?cleos da rafe est?o localizados no tronco encef?lico, na linha m?dia ou suas proximidades. Os grupamentos serotonin?rgicos foram originalmente classificados alfanumericamente como B1 a B9 no sentido caudorrostral no rato e podem ser divididos em grupos superior e inferior. Neste trabalho a distribui??o dos neur?nios serotonin?rgicos foi estudada com imunoistoqu?mica no c?rebro do moc? (Kerodon rupestris), uma esp?cie de roedor end?mica da regi?o Nordeste do Brasil. A localiza??o citoarquitet?nica dos neur?nios serotonin?rgicos foi estabelecida em s?ries de sec??es coronais e sagitais adjacentes submetidas a colora??o pelo m?todo de Nissl e imunoistoqu?mica para 5-HT. Assim, foram delimitados os n?cleos da rafe linear rostral, linear caudal, dorsal, mediano, paramediano e pontino da rafe e grupamento B9, compondo o grupo rostral, e os n?cleos interp?sito, magno, obscuro e p?lido, compondo o grupo caudal, compar?vel ao que j? foi descrito para outras esp?cies de mam?feros
Hess, Marielle. "Entwicklung von MS-Bindungsassays für den Serotonin-Transporter". Diss., lmu, 2011. http://nbn-resolving.de/urn:nbn:de:bvb:19-138516.
Pełny tekst źródłaSpitzer, Nadja. "Identification and functional analysis of crustacean serotonin receptors". unrestricted, 2006. http://etd.gsu.edu/theses/available/etd-07192006-121025/.
Pełny tekst źródłaTitle from title screen. Donald H. Edwards, committee chair; Deborah J. Baro, co-chair; Charles D. Derby, Larry J. Young, committee members. Electronic text (182 p. : ill. (some col.)) : digital, PDF file. Description based on contents viewed May 21, 2007. Includes bibliographical references (p. 161-182).