Rozprawy doktorskie na temat „Sensory receptors”
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Piñón, Luzia Giraldez Pereira. "Neurotrophin switching in developing sensory neurons". Thesis, University of St Andrews, 1997. http://hdl.handle.net/10023/14774.
Pełny tekst źródłaOverend, Tim. "The effect of frusemide on intrapulmonary sensory receptors". Thesis, Liverpool John Moores University, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.337788.
Pełny tekst źródłaAssis, Temilce Simoes de. "Characterisation of P2 receptors expressed in sensory neurones". Thesis, University of Strathclyde, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.288723.
Pełny tekst źródłaBrumovsky, Pablo R. "Neuropeptides, sensory neurons and pain modulation /". Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-442-2/.
Pełny tekst źródłaHörnberg, Maria. "Effects of retinoic acid in the mouse olfactory sensory systems /". Umeå : Univ, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1371.
Pełny tekst źródłaKarchewski, Laurie Ann. "Neurotrophins and neurotrophin receptors in adult primary sensory neurons". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0034/NQ63884.pdf.
Pełny tekst źródłaMeira, Guilherme Louzada Silva. "Analíse da expressão do receptor olfativo M93 em sistemas heterólogos". Universidade de São Paulo, 2004. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-31082016-115408/.
Pełny tekst źródłaThe mammalian olfactory system can discrim inate thousands of odorants present in the environrnent. Approximately 1000 different olfactory receptors (ORs) are expressed in the olfactory epithelium (OE) of the nose. The ORs detect odorants and transmit the resulting signals to the olfactory bulb (OB) of the brain. ORs belong to the G-protein-coupled receptor (GPCR) super family and have seven putative transmembrane domains. For unknown reasons, the ORs are retained in the endoplasmatic reticulum when expressed in heterologous mammalian cell lines. Probably accessory proteins are required for the sorting of the ORs to the cell surface. In the present work, we used the OR M93 to study the mechanisms of OR expression. Our goals were to (1) construct an expression vector for OR M93 in fusion with GFP in yeast and (2) to identify proteins expressed in the mouse OE that interact with ORs. The analysis by fluorescence microscopy suggested that OR M93 in fusion with GFP was retained in the endoplasmic reticulum (ER) of yeast. We used the yeast two-hybrid system to screen a mouse OE cDNA library with a bait corresponding to the N-terminal region ofthe üR M93. Four potential candidates were identified: HLA-B associated transcript 3 (BAT-3/Scythe), transmembrane 4 superfamily (CD82 member), transmembrane 4 superfamily (TSPN-3 member) and syndecan (SDC2). In situ hybridization analysis suggests that OAP-l protein represents the best candidate for interaction with OR M93. We suggest the OAP-l protein could be an accessory protein required for the sorting of the ORs to the cell surface in heterologous cell lines.
Jones, Christopher M. "Expression and folding studies of the ankyrin repeat domain of the capsaicin receptor". Click here for download, 2006. http://wwwlib.umi.com/cr/villanova/fullcit?p1432833.
Pełny tekst źródłaJohnson, Claire. "Sensory and chemical analysis of the bitter-sweet taste interaction". Thesis, University of Reading, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.262530.
Pełny tekst źródłaSalazar, Eduardo 1962. "GABAᴀ Receptors in Rat Whisker Barrel Cortex: Effects of Sensory Deprivation". Thesis, University of North Texas, 1995. https://digital.library.unt.edu/ark:/67531/metadc279232/.
Pełny tekst źródłaHashimoto, Sanae. "Search for receptor mediated processes in Amoeba proteus /". Connect to online version, 2006. http://ada.mtholyoke.edu/setr/websrc/pdfs/www/2006/142.pdf.
Pełny tekst źródłaCselényi, Zsolt. "Development, validation and application of advanced neuroimaging analysis tools for in vivo neuroreceptor studies /". Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-261-6/.
Pełny tekst źródłaVerge, Valerie Mary Kathleen. "Properties of intact and injured sensory neurons with nerve growth factor receptors". Thesis, McGill University, 1989. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=74557.
Pełny tekst źródłaSTANTCHEVA, KALINA KRASSIMIROVA. "A SUBPOPULATION OF ITCH RECEPTORS MARKED BY RET EXPRESSION". Doctoral thesis, Università degli Studi di Milano, 2014. http://hdl.handle.net/2434/241111.
Pełny tekst źródłaPatullo, Blair. "Sensory biology of aquatic Australian crustaceans". Connect to thesis, 2010. http://repository.unimelb.edu.au/10187/8393.
Pełny tekst źródła• abdominal muscle mass was positively correlated to the size of the electrical fields produced by swimming crayfish,
• behaviour changed in response to contact with different structures and textures of wall surfaces,
• computer analysis of underwater behaviour was similar to that scored by a human observer,
• the level of aggression in groups of crayfish changed as group size increased, and
• two species of crayfish responded to electrical fields in the water by decreasing their locomotory movement.
These results reveal a way in which physiology relates to behaviour, how crayfish and other crustaceans may sense the invisible and behave in aquaculture ponds, as well as documenting methodology to further investigate these areas in the future.
Lau, Mark 1959. "Factors affecting the expression of acetylcholine receptors on rat sensory neurons in culture". Thesis, McGill University, 1986. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=65516.
Pełny tekst źródłaMyers, Warren Kellen. "Pain and perspective| Compartmented co-culture to evaluate sensory neuron peripheral glutamate receptors". Thesis, Oklahoma State University, 2016. http://pqdtopen.proquest.com/#viewpdf?dispub=10191366.
Pełny tekst źródłaThe neurotransmitter L-Glutamate is the primary excitatory neurotransmitter of sensory neurons in the dorsal root ganglion (DRG). These neurons may also express ionotropic glutamate receptors, causing the potential for them to be directly excited by their own release of glutamate, from a neighboring neuron, or from other tissues. Glutamate is elevated in tissues after injury or inflammation, and iGluR signaling from the periphery has been shown to increase signaling in DRG neurons and contribute to the development of chronic pain. Targeting pharmacologic intervention of sensory neuron iGluRs present in peripheral terminals may constitute an attractive alternative or augmentation to chronic pain treatment regimens. A compartmented culture system was devised to enable the co-culture of sensory neurons and keratinocyte stem cells in discrete compartments to simulate a skin tissue in vitro, and allow focal agonist application to peripheral terminals. Activation of peripheral receptors with focal agonist application caused the propagation of signals towards somata of neurons in a fluidically separated compartment, causing excitatory post-synaptic currents (EPSC) that were observed and recorded via voltage-clamped whole-cell electrophysiology. EPSC responses observed exhibited statistically significant differences between the ? values of the EPSCs after respective agonist exposure. Immunofluorescent labeling and visualization of receptor expression showed that iGluR subunits are expressed in sensory neuron somata, sensory neuron peripheral processes, non-neuronal cells from the DRG, and keratinocyte stem cells. The implementation of this co-culture clamping facilitates the spatially discrete interaction of neuronal and non-neuronal cell types for the characterization of their interfaces, as well as for the discrete application of pharmacologic agents along axons to evaluate their spatially constrained influence on activity at a cellular, and intercellular level. The spatially restricted application of agonists represents a chemotransmissive instigation of electrochemical activity in neurons for studying EPSCs, instead of electrically stimulating a presynaptic cell, and so more faithfully represents what would occur in vivo. Using this system to test novel pharmaceuticals represents an intermediary step between the study of ligand interactions with receptors and systemic administration to experimental animals. The identification of the active receptors and their subunit-specific peripheral expression yield alternative therapeutic targets for chronic pain treatment.
El-Nour, Husameldin. "Study of serotonin, innervation and sensory neuropeptides in allergic contact dermatitis /". Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-464-3/.
Pełny tekst źródłaMwilaria, Esther K. "Psychophysical measures of detection & discrimination and effects of GABA blockade in the moth Manduca sexta". Morgantown, W. Va. : [West Virginia University Libraries], 2007. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=5071.
Pełny tekst źródłaTitle from document title page. Document formatted into pages; contains vi, 53 p. : ill. Vita. Includes abstract. Includes bibliographical references (p. 50-51).
Montelius, Andreas. "Role of transcription factors in sensory neuron specification /". Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-115-9/.
Pełny tekst źródłaSchmidt, Yvonne [Verfasser]. "Peripheral opioid receptors and inhibition of sensory neuron excitability following nerve injury / Yvonne Schmidt". Berlin : Freie Universität Berlin, 2011. http://d-nb.info/1025510518/34.
Pełny tekst źródłaKamaid, Toth Andres. "BMP4 regulation of sensory organ development in the chick inner ear". Doctoral thesis, Universitat Pompeu Fabra, 2008. http://hdl.handle.net/10803/7137.
Pełny tekst źródłaThe specific aims proposed were:
1- Analyze the cellular effects caused by addition of BMP4 in a model of isolated chick otic vesicles in culture, measuring parameters of cell proliferation, cell death and sensory cell fate specification.
2- Analyze the cellular effects caused by inhibition of BMP4 signaling in a model of isolated chick otic vesicles in culture, measuring parameters of cell proliferation, cell death and sensory cell fate specification.
3- Analyze the expression in the innear ear of downstream targets of BMP signalling, in particular, analyse the members of Id gene family.
4- Analyze the regulation of Id genes by BMP signalling in the inner ear.
5- Analyze the expression of genes involved in the process of terminal differentiation, in particular, Btg1 and Btg2 genes
6- Analyze the regulation of Btg1 and Btg2 gene by BMP signalling in the inner ear
Rieling, Janine Ann. "Sensory receptor neuron turnover in the olfactory epithelium of the snail, Achatina fulica : an autoradiographical study". Thesis, McGill University, 1985. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=63382.
Pełny tekst źródłaLiu, Min. "Coexpression of recombinant P2X receptors and their relation to ATP gated channels in sensory neurons". Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.251671.
Pełny tekst źródłaPal, Choudhuri Shreoshi. "Receptors for the detection of L-amino acids and IMP by mouse taste sensory cells". ScholarWorks @ UVM, 2016. http://scholarworks.uvm.edu/graddis/473.
Pełny tekst źródłaImaizumi, Kazuo. "Peripheral representation of sound frequency in cricket auditory system : beyond tonotopy". Thesis, McGill University, 2000. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=36956.
Pełny tekst źródłaHayes, Heather Brant. "Biomechanics and electrophysiology of sensory regulation during locomotion in a novel in vitro spinal cord-hindlimb preparation". Diss., Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/42797.
Pełny tekst źródłaVick, Jonathan. "The Contribution of Purinergic P2X and P2Y Receptors to the Excitability of Mouse Vomeronasal Sensory Neurons". ScholarWorks @ UVM, 2014. http://scholarworks.uvm.edu/graddis/283.
Pełny tekst źródłaBatista, Daniel Rodrigo. "Estudo dos receptores purinérgicos em células gliais do glânglio da raiz dorsal". Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/42/42137/tde-16032009-122053/.
Pełny tekst źródłaPurinergic receptors are expressed and play role in the sinalization between neurons and glia. In dorsal root ganglia the soma of the sensory neurons is surrounded by a layer of satellite glial cells, whose function is unclear. There are evidences that ATP is released by neurons to act on receptors in satellite cells. So far, the nature of the purinergic receptors of satellite cells was not fully investigated. This study shows the presence of metabotropics purinergic receptors P2Y1, P2Y2 and/or P2Y4, e P2Y6 in satellite cells from dorsal root ganglia of newborn rats. The demonstration was carried on following the transient increases in intracellular calcium concentration induced by a purinergic agonist. As time goes by, in the presence of fetal bovine serum, there is a remarkable proliferation of glial cells, with predominant fusiform shapes. The fusiform cells also express P2Y1, P2Y2 and/or P2Y4, e P2Y6 receptors. These informations add on the understanding of the complex phenomena of neuron-glia interaction.
Impey, Danielle. "Assessment of Transcranial Direct Current Stimulation (tDCS) on MMN-Indexed Auditory Sensory Processing". Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/35576.
Pełny tekst źródłaMora, García Natalia. "Analisis de la expresión y la función del gen beta-amyloid protein precursor like en relación a la vía de RasI en el disco imaginal de ojo de Drosophila melanogaster". Doctoral thesis, Universitat de Barcelona, 2012. http://hdl.handle.net/10803/104149.
Pełny tekst źródłaIn a genome wide expression profile search for genes that characterize the Drosophila R7 photoreceptor specification we found Appl, the ortholog of human APP and a key factor in the pathogenesis of Alzheimer’s disease. We analyzed Appl expression in the eye imaginal disc and found that is highly accumulated in R7 photoreceptor cells. The R7 photoreceptor is responsible for UV light detection. To explore the link between high expression of Appl and R7 function, we have analyzed Appl null mutants and found reduced preference for UV light, likely due to mistargeted R7 axons. Moreover, axon mistargeting and inappropriate light discrimination are enhanced in combination with neurotactin mutants. R7 differentiation is triggered by the inductive interaction between R8 and R7 precursors, which results in a burst of Ras1/MAPK activated by the tyrosine kinase receptor Sevenless. Thus, we have studied whether Ras1/MAPK is responsible for the high Appl expression. Inhibition of Ras1 signaling leads to reduced Appl expression, whereas constitutive activation drives ectopic Appl expression. We show that Appl is directly regulated by the Ras/MAPK pathway through a mechanism mediated by PntP2, an ETS transcription factor that specifically binds ETS sites in the Appl regulatory region. Also, the zebrafish appb expression increased after ectopic fgfr activation in the neural tube of zebrafish embryos, suggesting a conserved regulatory mechanism.
Conde, Silvia Margarida Vilares Santos. "Functional significance of adenosine in carotid body chemosensory activity in control and chronically hypoxic animals". Doctoral thesis, Faculdade de Ciências Médicas. Universidade Nova de Lisboa, 2007. http://hdl.handle.net/10362/5524.
Pełny tekst źródłaCarvalho, Viviane Fernandes de. "Avaliação da sensibilidade cutânea em pés de pacientes diabéticos através do Pressure Specified Sensory Device TM". Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/5/5158/tde-29052008-112413/.
Pełny tekst źródłaNeuropathy is a severe progressive loss of protective sensation on the feet, making the patient more vulnerable to mechanical trauma and consequently more suitable to the development of chronic wounds, major distortion of the foot bone architecture and eventually to limb amputation. Prophylaxis should be enforced to avoid foot ulceration and for that, evaluation of the degree of loss of sensation on the skin is essential. The PSSD (Pressure Specified Sensory Device(TM)) was developed in order to quantify the threshold of pressure applied to the skin that could be recognized as positive by the patient. Pressure of one or two points is tested both statically and with movement, thus assessing the function of fast and slow response nerve fibers. Threshold of two-point discrimination was also measured in mm. Thirty four (n = 34) diabetic patients, type II, with no previous history of wounds on the lower extremity were studied using the tests, one point static (1PE), one point moving (1PD) and two points static (2 PE), and moving (2 PD) on the cutaneous territory of the fibular nerve and posterior tibial nerve (two territories - medial plantar and calcaneous nerves). The control group (28 non diabetic patients) was assessed by the same exams and the results were compared. In the diabetic group the cutaneous territories were also evaluated using the conventional Semmes-Weinstein filament nº 5,07 e vibrometer of the 128 Hz. Altered values were observed for the static and dynamic tests over the three studied nerve territories. The differences were statically significant (p < 0,05). Comparing the threshold of sensibility between sensitive and non sensitive diabetic patients to MSW nº 5,07 test, we observed that p-value range was 0,018 0,113 when 1PE test was applied, and 0,002 0,083 when 2PE test was applied, according to the cutaneous territories evaluated. Numeric quantification of the threshold of pressure allows us to determine the status of the fiber/receptor structures as well as the functional deficit of nerve fibers. Our findings suggest that PSSD(TM) is an adjuvant tool to evaluate the degree of loss of sensation on the skin.
Wong, Jin Yan Hilary. "The octopaminergic modulatory circuitry of the Drosophila larval mushroom body calyx". Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/285104.
Pełny tekst źródłaSouleymane, Diallo. "Coding of tsetse repellents by olfactory sensory neurons: towards the improvement and the development of novel tsetse repellents". University of Western Cape, 2021. http://hdl.handle.net/11394/8039.
Pełny tekst źródłaTsetse flies are the biological vectors of human and animal trypanosomiasis and hence representant medical and veterinary importance. The sense of smell plays a significant role in tsetse and its ecological interaction, such as finding blood meal source, resting, and larvicidal sites and for mating. Tsetse olfactory behaviour can be exploited for their management; however, olfactory studies in tsetse flies are still fragmentary. Here in my PhD thesis, using scanning electron microscopy, electrophysiology, behaviour, bioinformatics and molecular biology techniques, I have investigated tsetse flies (Glossina fuscipes fuscipes) olfaction using behaviourally well studied odorants, tsetse repellent by comparing with attractant odour. Insect olfaction is mediated by olfactory sensory neurons (OSNs), located in olfactory sensilla, which are cuticular structures exposed to the environment through pore and create a platform for chemical communication.
Stevanovic, Bettina. "The effect of learning on pitch and speech perception : influencing perception of Shepard tones and McGurk syllables using classical and operant conditioning principles". Thesis, View thesis, 2007. http://handle.uws.edu.au:8081/1959.7/33694.
Pełny tekst źródłaColton, Craig K. "TRPV3 is a polymodal receptor". Columbus, Ohio : Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1164046830.
Pełny tekst źródłaSouleymane, Diallo. "Coding of tsetse repellents by olfactory sensory neurons: towards the improvement and the development of novel". University of the Western Cape, 2020. http://hdl.handle.net/11394/8236.
Pełny tekst źródłaTsetse flies are the biological vectors of human and animal trypanosomiasis and hence representant medical and veterinary importance. The sense of smell plays a significant role in tsetse and its ecological interaction, such as finding blood meal source, resting, and larvicidal sites and for mating. Tsetse olfactory behaviour can be exploited for their management; however, olfactory studies in tsetse flies are still fragmentary. Here in my PhD thesis, using scanning electron microscopy, electrophysiology, behaviour, bioinformatics and molecular biology techniques, I have investigated tsetse flies (Glossina fuscipes fuscipes) olfaction using behaviourally well studied odorants, tsetse repellent by comparing with attractant odour. Insect olfaction is mediated by olfactory sensory neurons (OSNs), located in olfactory sensilla, which are cuticular structures exposed to the environment through pore and create a platform for chemical communication. In the sensilla shaft the dendrite of OSNs are housed, which are protected by called the sensillum lymph produced by support cells and contains a variety of olfactory proteins, including the odorant binding protein (OBP) and chemosensory proteins (CSP). While on the dendrite of OSNs are expressed olfactory receptors. In my PhD, studies I tried to decipher the sense of smell in tsetse fly. In the second chapter, I demonstrated that G. f. fuscipes is equipped with diverse olfactory sensilla, that various from basiconic, trichoid and coeloconic. I also demonstrated, there is shape, length, number difference between sensilla types and sexual dimorphism. There is a major difference between male and female, while male has the unique basiconic sensilla, club shaped found in the pits, which is absent from female pits. In my third chapter, I investigated the odorant receptors which are expressed on the dendrite of the olfactory sensory neurons (OSNs). G. f. fuscipes has 42 ORs, which were not functionally characterised. I used behaviourally well studied odorants, tsetse repellents, composed of four components blend. I demonstrated that tsetse repellent is also a strong antifeedant for both G. pallidipes and G. f. fuscipes using feeding bioassays as compared to the attractant odour, adding the value of tsetse repellent. However, the attractant odour enhanced the feeding index. Using DREAM (deorphanization of receptors based on expression alterations of mRNA levels). I found that in G. f. fuscipes, following a short in vivo exposure to the individual tsetse repellent component as well as an attractant volatile chemical, OSNs that respond to these compounds altered their mRNA expression in two opposite direction, significant downregulation and upregulation in their number of transcripts corresponding to the OR that they expressed and interacted with odorant. Also, I found that the odorants with opposite valence already segregate distinctly at the cellular and molecular target at the periphery, which is the reception of odorants by OSNs, which is the basis of sophisticated olfactory behaviour. Deorphanization of ORs in none model insect is a challenge, here by combining DREAM with molecular dynamics, as docking score, physiology and homology modelling with Drosophila a well-studied model insects, I was able to predict putative receptors of the tsetse repellent components and an attractant odour. However, many ORs were neutral, showing they were not activated by the odorants, demonstrating the selectivity of the technique as well as the receptors. In my fourth chapter, I investigated the OBPs structures and their interaction with odorants molecules. I demonstrated that OBPs are expressed both in the antenna, as well as in other tissues, such as legs. I also demonstrated that there are variations in the expression of OBPs between tissues as well as sexes. I also demonstrated that odorants induced a fast alteration in OBP mRNA expression, some odorants induced a decrease in the transcription of genes corresponding to the activated OBP and others increased the expression by many fold in OBPs in live insect, others were neutral after 5 hours of exposure. Moreover, with subsequent behavioural data showed that the behavioural response of G. f. fuscipes toward 1-octen-3-ol decreased significantly when 1-octen-3-ol putative OBPs were silenced with feeding of double-stranded RNA (dsRNA). In summary, our finding whereby odorant exposure affects the OBPs mRNA, their physiochemical properties and the silencing of these OBPs affected the behavioural response demonstrate that the OBPs are involved in odour detection that affect the percept of the given odorant. The expression of OBPs in olfactory tissues, antenna and their interaction with odorant and their effect on behavioural response when silenced shows their direct involvement in odour detection and reception. Furthermore, their expression in other tissues such as legs indicates they might also have role in other physiological functions, such as taste.
Taguchi, Toru. "Altered Response to the Mechanical Stimulation of C-Fiber Sensory Receptors Recorded in Vitro from the Rat Exercised Muscle(RIEM Conference Ⅱ,2003)". Research Institute of Environmental Medicine, Nagoya University, 2003. http://hdl.handle.net/2237/7611.
Pełny tekst źródłaCattaneo, Alberto Maria. "Unveiling sensory mechanisms for the control of two insect pests: from behaviour to molecular interactions". Doctoral thesis, country:IT, 2015. http://hdl.handle.net/10449/29924.
Pełny tekst źródłaStevanovic, Bettina. "The effect of learning on pitch and speech perception influencing perception of Shepard tones and McGurk syllables using classical and operant conditioning principles /". View thesis, 2007. http://handle.uws.edu.au:8081/1959.7/33694.
Pełny tekst źródłaA thesis submitted to the University of Western Sydney, College of Arts, School of Psychology in fulfilment of the requirements for the degree of Doctor of Philosophy. Includes bibliography.
Duncan, Robert Keith. "Finite-element analysis of inner ear hair bundles : a parameter study of bundle mechanics /". Thesis, This resource online, 1993. http://scholar.lib.vt.edu/theses/available/etd-09292009-020226/.
Pełny tekst źródłaGomes, Isa. "Effects of endocrine disruptors on Phallusia mammillata embryonic development". Thesis, Sorbonne université, 2018. http://www.theses.fr/2018SORUS419/document.
Pełny tekst źródłaBisphenol A (BPA) is a plastic-derived molecule that is now considered an endocrine disruptor (ED). BPA impair hormonal systems via binding to nuclear receptors (NRs) and it has been linked to neurodevelopmental disorders, possibly due to the presence of some NRs in the vertebrate brain. BPA has been reported to affect marine invertebrates such as ascidians, but how is BPA acting is not known. My PhD project is aimed at deciphering the toxicity of BPA on embryonic development of the marine invertebrate chordate Phallusia mammillata (Tunicata). Firstly, I assessed the embryonic expression of P. mammillata NRs and found that 5 are expressed within the ascidian brain (also called sensory vesicle, SV) (COUP, ERR, PPAR, PXR/VDR) or nearby (TR). Interestingly, the human orthologues of most of these NRs are known to bind BPA. Secondly, I assessed BPA toxicity during P. mammillata embryonic development and found that BPA is toxic in a dose-dependent manner. I also show that at micromolar doses BPA induces neurodevelopmental toxicity by impairing differentiation of the ascidian pigmented sensory organ (PSO). I further show that this phenotype is specific to bisphenols. Finally, estrogen-related receptor (ERR) agonists and antagonists partially phenocopied BPA phenotype. Interestingly, I found that Pm-ERR is expressed in the larval SV close to the ascidian PSO, thus suggesting an involvement of Pm-ERR in the BPA phenotype. Furthermore, the complex pleiotropic action of BPA together with the presence of other NRs in the ascidian larval brain raises the possibility that these NRs are involved both in ascidian brain development and EDs toxicity, thus they should not be overlooked
Lin, Chia-Hui. "The Effects of Growth Hormone in the Inner Ear of Zebrafish (Danio rerio) during Hair Cell Regeneration". TopSCHOLAR®, 2010. http://digitalcommons.wku.edu/theses/191.
Pełny tekst źródłaChappell, Tyson. "The long-term teratogenic effect of prenatal alcohol exposure on the somatosensory and motor cortex of rats". View the abstract Download the full-text PDF version, 2007. http://etd.utmem.edu/ABSTRACTS/2007-013-Chappell-index.htm.
Pełny tekst źródłaTitle from title page screen (viewed on February 29, 2008). Research advisor: Robert S. Waters, Ph.D. Document formatted into pages (xix, 179 p. : ill.). Vita. Abstract. Includes bibliographical references (p. 152-178).
Gomes, Isa. "Effects of endocrine disruptors on Phallusia mammillata embryonic development". Electronic Thesis or Diss., Sorbonne université, 2018. http://www.theses.fr/2018SORUS419.
Pełny tekst źródłaBisphenol A (BPA) is a plastic-derived molecule that is now considered an endocrine disruptor (ED). BPA impair hormonal systems via binding to nuclear receptors (NRs) and it has been linked to neurodevelopmental disorders, possibly due to the presence of some NRs in the vertebrate brain. BPA has been reported to affect marine invertebrates such as ascidians, but how is BPA acting is not known. My PhD project is aimed at deciphering the toxicity of BPA on embryonic development of the marine invertebrate chordate Phallusia mammillata (Tunicata). Firstly, I assessed the embryonic expression of P. mammillata NRs and found that 5 are expressed within the ascidian brain (also called sensory vesicle, SV) (COUP, ERR, PPAR, PXR/VDR) or nearby (TR). Interestingly, the human orthologues of most of these NRs are known to bind BPA. Secondly, I assessed BPA toxicity during P. mammillata embryonic development and found that BPA is toxic in a dose-dependent manner. I also show that at micromolar doses BPA induces neurodevelopmental toxicity by impairing differentiation of the ascidian pigmented sensory organ (PSO). I further show that this phenotype is specific to bisphenols. Finally, estrogen-related receptor (ERR) agonists and antagonists partially phenocopied BPA phenotype. Interestingly, I found that Pm-ERR is expressed in the larval SV close to the ascidian PSO, thus suggesting an involvement of Pm-ERR in the BPA phenotype. Furthermore, the complex pleiotropic action of BPA together with the presence of other NRs in the ascidian larval brain raises the possibility that these NRs are involved both in ascidian brain development and EDs toxicity, thus they should not be overlooked
Kelleher, Jayne Hannah. "Isolation of sensory neurons in vitro and generation of a conditional inducible transgenic mouse line against nerve growth factor (NGF) receptors to investigate the role of NGF in pain". Thesis, King's College London (University of London), 2017. https://kclpure.kcl.ac.uk/portal/en/theses/isolation-of-sensory-neurons-in-vitro-and-generation-of-a-conditional-inducible-transgenic-mouse-line-against-nerve-growth-factor-ngf-receptors-to-investigate-the-role-of-ngf-in-pain(1d0d15ee-7aec-4f07-a307-351c75de1050).html.
Pełny tekst źródłaMarchenkova, Anna. "A study of modulation of P2X3 and TRPV1 receptors by the B-type natriuretic peptide and novel synthetic compounds in trigeminal sensory neurons of wild type and migraine-model mice". Doctoral thesis, SISSA, 2015. http://hdl.handle.net/20.500.11767/4888.
Pełny tekst źródłaColtro, Pedro Soler. "Avaliação da sensibilidade cutânea do retalho perfurante da artéria pudenda interna nas reconstruções perineais". Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/5/5132/tde-01122014-152200/.
Pełny tekst źródłaINTRODUCTION: The treatment of anorectal malignancies requires resection that can lead to extensive perineal defects. These defects require reconstruction which should be performed, preferably, with flaps. Among them, we highlight the internal pudendal artery perforator flap, located on the gluteal fold, vascularized by cutaneous perforator vessels from the internal pudendal artery, and innervated by branches from the pudendal nerve and the posterior femoral cutaneous nerve. This flap has many advantages compared to others used for perineal reconstruction, and data related to the evaluation of its cutaneous sensibility are scarce, discrepant and subject to methodological criticisms. OBJECTIVE: To evaluate cutaneous sensibility of the internal pudendal artery perforator flap 12 months after perineal reconstruction in abdominoperineal resection of rectum, and compare it with the preoperative cutaneous sensibility of the gluteal fold (flap donor area). METHODS: A prospective study of 25 patients undergoing abdominoperineal resection of rectum for anorectal malignancies, and reconstruction with the internal pudendal artery perforator flap, in bilateral VY advancement. The modalities of tactile, pain, thermal and vibration sensibility were analyzed in four areas of the gluteal fold preoperatively and in the four corresponding areas of the flap 12 months after surgery. Tactile sensibility was assessed using the Pressure Specified Sensory Device(TM) (PSSD(TM)), a device that measures the pressure applied to the skin, static or moving. The other types of sensibility were analyzed with the forced-choice method, using a needle for pain sensibility, hot/cold contact for thermal sensibility and 128 Hz tuning-fork for vibration sensibility. RESULTS: The tactile sensibility thresholds measured with PSSD(TM) on the internal pudendal artery perforator flap 12 months after perineal reconstruction were similar to tactile sensibility thresholds of the gluteal fold preoperatively, both in static and moving pressure tests. The comparison between these thresholds showed no statistically significant difference, with p values greater than 0.05 in the four areas evaluated, for both tests. All patients presented pain, thermal and vibration sensibility in all four areas tested, on the both the gluteal fold preoperatively and the flap 12 months after surgery. CONCLUSION: In perineal reconstructions after abdominoperineal resection of rectum, it is expected that the cutaneous sensibility of the internal pudendal artery perforator flap is maintained
Bates, Ferdia. "Design and development of molecularly imprinted polymers and imprinted sensors". Doctoral thesis, Universitat Autònoma de Barcelona, 2016. http://hdl.handle.net/10803/399170.
Pełny tekst źródłaThis thesis was predominantly undertaken to study and investigate molecular imprinted polymers (MIPs) with a view to their use as high longevity sensing elements in sensor arrays. The research line of the thesis was intended to lead to the integration of these imprinted arrays into an Electronic Tongue (ET) sensing system which is the area of expertise of the research group in which this project was primarily executed. Having initially executed a review of the literature, focusing initially on the application of the MIPs to an electrochemical device, an imprinted voltammetric sensor and a complimentary sensing procedure was developed using a combination of protocols extracted from the literature. This sensor, described in Article 1, had good selectivity toward the primary analyte, theophylline, and specificity against structural analogues. Though the design of the sensor allowed for significantly improved regeneratibility of the sensor relative to similar systems in the literature, the insulating nature of the polymers used in the MIP reduced the electron transfer rate at the sensor surface and thus resulted in a reduction in sensitivity. Following this initial experimental study, a secondment was undertaken in the University of Leicester under the supervision of Professor Sergey Piletsky. During this period, an intensive study of the design process of molecular imprinting, aided by an in-house computational molecular modelling platform, was conducted focusing on the design of an imprinted receptor for the low solubility 'model template', melamine. This MIP was successfully synthesised, characterised and used in the detection of melamine in milk samples, as detailed in Article 2. Further development of computational modelling techniques for the evaluation of MIP modelling techniques was also achieved with a view to create a virtual evaluation technique for the design of imprinted receptor sites optimised for the requirements of their application to an ET sensor array using the skills acquired during the Leicester secondment as detailed in Article 3. As detailed in the final chapter of this thesis, the insight into the imprinting process which was acquired during the research has been used to design a sensor array system which meets the specifications of ET experimental runs. This takes the form of the introduction of the research topic computationally selected polyelectrolytes, immobilised onto a voltammetric electrode surface via highly robust conducting graphite ink. Additional recommendations are also made to further enhance the on-going MIP projects within the laboratory, such as the separation of the MIP and the electrode to increase MIP regeneratibility. Some final suggestions for some other inter-institutional collaboration are also presented which aim to creating portable ET system for in-field sample collection and analysis.