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McGrath, John Joseph. "The epidemiology of schizophrenia /". [St. Lucia, Qld.], 2002. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe17061.pdf.
Pełny tekst źródłaCannon, Mary. "Investigating the developmental epidemiology of schizophrenia". Thesis, King's College London (University of London), 2002. https://kclpure.kcl.ac.uk/portal/en/theses/investigating-the-developmental-epidemiology-of-schizophrenia(24204567-5b9d-4cef-8eb7-034d59b7644a).html.
Pełny tekst źródłaCastle, David Jonathan. "Schizophrenia in Camberwell, 1965-1984". Doctoral thesis, University of Cape Town, 1995. http://hdl.handle.net/11427/27660.
Pełny tekst źródłaCastle, David J. "Schizophrenia in Camberwell, 1965-1984". Doctoral thesis, University of Cape Town, 1995. http://hdl.handle.net/11427/25760.
Pełny tekst źródłaMorgan, Vera Anne. "Intellectual disability co-occurring with schizophrenia and other psychiatric illness : epidemiology, risk factors and outcome". University of Western Australia. School of Psychiatry and Clinical Neurosciences, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0209.
Pełny tekst źródłaRoberts, Seth. "Season of Birth and Risk for Schizophrenia". VCU Scholars Compass, 2008. http://scholarscompass.vcu.edu/etd/1633.
Pełny tekst źródłaWittchen, Hans-Ulrich, i Frank Jacobi. "Size and burden of mental disorders in Europe - a critical review and appraisal of 27 studies". Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2013. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-112617.
Pełny tekst źródłaMiddlebro', Alison Kathleen. "A proposal for surveillance and case registry of schizophrenia in Ontario". Thesis, University of Ottawa (Canada), 2011. http://hdl.handle.net/10393/28882.
Pełny tekst źródłaWittchen, Hans-Ulrich, i Frank Jacobi. "Size and burden of mental disorders in Europe - a critical review and appraisal of 27 studies". Technische Universität Dresden, 2005. https://tud.qucosa.de/id/qucosa%3A25813.
Pełny tekst źródłaWiderlöv, Birgitta. "Long-Term Functional Psychosis : Epidemiology in Two Different Counties in Sweden". Doctoral thesis, Uppsala University, Department of Neuroscience, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7466.
Pełny tekst źródłaThis thesis is based on two independent studies, the first in Stockholm County (index year 1984; n=302), and the second, a replication and validation study, in Uppsala County (index year 1991; n=455).
The general aim was to study all individuals with Long-term Functional Psychosis (LFP) within the two counties of Sweden from an epidemiological perspective and to perform specific studies on a subgroup of individuals with schizophrenia. In the Stockholm study, the total one-year LFP prevalence was 5.3/1 000; in the the rural, suburban and urban areas it was 3.4, 5.6 and 6.6/1 000, respectively. The total one-year prevalence of LFP in Uppsala was 7.3/1 000; in the rural, peripheral city and central city areas it was 6.0, 7.0, and 8.7/1 000, respectively.
Within the non-schizophrenic subpopulation, a pronounced difference was demonstrated between the two studies with substantially higher prevalence rates in the Uppsala study. The schizophrenic subgroup in Uppsala was re-diagnosed using parallel diagnostic systems (DSM-III, DSM-III-R, DSM-IV and ICD-10), and reasonably comparable prevalence estimates were obtained.
In both studies antipsychotic drugs were most frequently prescribed for the patients with schizophrenia, and the doses were considered as low to moderate. In the Uppsala study the doses of antipsychotic drugs decreased with a longer duration of illness, while the opposite was found in the Stockholm study.
The increased mortality rate among patients with schizophrenia was mainly due to unnatural causes of death and cardiovascular diseases, particularly among males.
The main methodological differences between the two studies were in the sampling procedures. In the Uppsala study, a larger number of care facilities were screened, and a broader set of diagnostic criteria were used for identifying cases from different registers.
Juola, P. (Pauliina). "Outcomes and their predictors in schizophrenia in the Northern Finland Birth Cohort 1966". Doctoral thesis, Oulun yliopisto, 2015. http://urn.fi/urn:isbn:9789526207728.
Pełny tekst źródłaTiivistelmä Tämän väitöstutkimuksen tarkoituksena oli tutkia skitsofrenian ennustetta ja ennustetekijöitä meta-analyysin ja Pohjois-Suomen vuoden 1966 syntymäkohortin avulla. Pohjois-Suomen vuoden 1966 syntymäkohortti on valikoitumaton, yleisväestöpohjainen kohortti, johon kuuluu 12 068 raskaana olevaa naista ja heidän 12 058 elävänä syntynyttä lastaan. Tässä väitöstutkimuksessa hyödynnetiin sairauskertomuksia, kansallisia rekistereitä sekä kahdessa laajassa kenttätutkimuksessa (34- ja 43-vuotistutkimukset) kerättyjä tietoja, jotka koostuvat haastatteluista, useista kyselyistä, neuropsykologisesta tutkimuksesta sekä aivojen magneettikuvauksesta. Tutkimuksen aiheesta riippuen aineiston koko eri osajulkaisuissa vaihteli 43:n ja 103:n välillä. Meta-analyysin perusteella 13,5 % skitsofreniaa sairastavista toipuu sekä kliinisesti että sosiaalisesti, eikä toipuminen ole viime vuosikymmeninä yleistynyt. Toipuneiden osuus oli suurempi köyhissä maissa. Pohjois-Suomen vuoden 1966 syntymäkohorttitutkimuksissa todettiin, että huonompi ennuste myöhempien sairaalahoitojen ja remission suhteen oli niillä, jotka olivat sairastuessaan nuoria ja naimattomia, joiden psykoosisairaus alkoi hitaasti ja joilla oli sairauden alkuvaiheissa enemmän sairaalahoitoja. Uusi löydös oli yhteys itsetuhoisten ajatusten ja myöhempien sairaalahoitojen välillä. Tiettyjen aivoalueiden tilavuuden ja rakenteen muutokset liittyivät monella tavoin samanhetkiseen taudinkuvaan 34-vuotiaana. Neurokognitiivisessa testauksessa parempi viivästetty kielellinen muisti 34-vuotiaana ennusti parempaa kokonaisvaltaista vointia (oireet, sairaalahoidot, sosiaaliset suhteet ja työssäkäynti yhdistettynä) ja parempi näönvarainen muisti ennusti työssäoloa 9 vuoden seurannassa. Tämän väitöstutkimuksen tulokset osoittavat, että skitsofreniasta toipuminen on mahdollista, vaikkakaan ei kovin yleistä. Vaikka taudinkulun ennustaminen on haastavaa, tutkimuksessa havaittiin useita kliinisesti merkittäviä tekijöitä, joilla on ennustearvoa jopa 20 vuoden seurannassa. Lisätutkimuksia kuitenkin tarvitaan, jotta löydettäisiin sellaisia ennustetekijöitä, joihin kohdistuvalla varhaisella interventiolla voitaisiin parantaa skitsofrenian ennustetta
Jongsma, Hannah E. "The role of the sociocultural context in explaining variance in incidence of psychosis and higher rates of disorder in minorities". Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/274061.
Pełny tekst źródłaSlaughter, Mary E. "Examining Substance Use Disorders and Mental Health Comorbidities in Patients Hospitalized for Schizophrenia and Bipolar Disorders". Case Western Reserve University School of Graduate Studies / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=case1517851653320388.
Pełny tekst źródłaAlmeida, Jouce Gabriela de. "Dor crônica em pacientes esquizofrênicos: prevalência e características". Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/7/7139/tde-22062009-124748/.
Pełny tekst źródłaBackground The prevalence of chronic pain among patients with psychiatric disturbance is possibly at least similar to the general population; however, there are too few studies in this field. Aims: to assess the chronic pain prevalence and its characteristics in schizophrenic patients, and to compare the quality of life of patients with and without chronic pain. Methods: Crossover study with a probabilistic sample of 205 adult outpatients with diagnosis of schizophrenia (mean age = 37 years, 65% men, mean scholarity = 9 years, 87% single, 65% living with parents, 25% had a job), treated in a governmental hospital of Sao Paulo city, Brazil. Patients were assessed by two instruments: characteristics of population/psychiatric disorder/pain and World Health Organization Quality of Life instrument (WHOQOL BREF). Results: Prevalence of pain in schizophrenic patients was 36,6%, (75 patients). Pain was more referred on abdomen (30.7%), followed by head/face/mouth (24%), and lumbar/sacral and coccyx regions (14.7%). Regarding frequency, 24% of the interviewees referred pain everyday with duration of 1 to 6 hours , 33.3% had pain two to three times a week, 40% referred pain with long intervals in between (once a week and each fortnight), and 2.7% (2 patients) once a month. Mean pain duration was 41 months (DP=42.8). Moderate pain was prevalent. Quality of life scores were low for patients without pain (domains 12,5; 11,9; 7,4;9,6) and with pain (domains 11,4; 11,9; 7,5; 10,6). In the comparison between groups, physical domain showed difference (P<0.001), which indicated that schizophrenic patients with pain have worse quality of life due to higher functional disability. There was no difference in other domains. Conclusion: This is a national original study, and in some aspects also original in the international scope. The prevalence of chronic pain in schizophrenic patients was similar to the general population and pain was significant in terms of duration, intensity and frequency. Quality of life was inferior to that described in other studies with schizophrenic patients and chronic pain worsened the quality of life. Higher attention to quality of life of schizophrenic patients and to the chronic pain control must be observed
Jansson, Lennart. "Needs of Support and Service in Mentally Disabled Clients : Population-Based Studies in a Swedish County". Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4841.
Pełny tekst źródłaGoldberg, Ximena. "Complex Models of Genetic and Environmental Influences on Human Cognition. Implications for Functional Psychoses / Modelos complejos de las influencias genéticas y ambientales en la cognición humana. Implicaciones para las psicosis funcionales". Doctoral thesis, Universitat de Barcelona, 2012. http://hdl.handle.net/10803/83588.
Pełny tekst źródłaEl constructo general de cognición humana involucra una serie de procesos mentales por medio de los cuales los individuos perciben, interpretan y, en consecuencia, actúan sobre la realidad que los rodea y sobre sus pares (Sternberg y Mio, 2009). En los últimos años, el reconocimiento de la diversidad humana y la variabilidad de los rasgos psicológicos entre los individuos ha promovido preguntas acerca de las diferencias inter-individuales que hacen a cada sujeto único en términos de cognición (Baddeley, 2003; Botvinick, 2008). En particular, los estudios de genética cuantitativa demuestran que tanto la variabilidad genética como los factores ambientales podrían estar involucrados en la expresión fenotípica de las funciones cognitivas (Plomin, 2011). Sin embargo, aún no son claros los mecanismos específicos por medio de los cuales los genes y el ambiente contribuyen a esta variabilidad. Las alteraciones cognitivas son un rasgo central en enfermedades mentales donde se presume que existen alteraciones del neurodesarrollo, como lo es la esquizofrenia. El modelo etiológico del neurodesarrollo de la esquizofrenia propone que esta enfermedad se expresaría como consecuencia de alteraciones neurobiológicas que iniciarían en una época temprana de la vida, incluso antes del desencadenamiento de los síntomas clínicos (van Os, 2009). No obstante, la presentación heterogénea de la enfermedad ha dificultado una comprensión más clara de los mecanismos involucrados en su manifestación. ¿Son todas las funciones cognitivas igualmente heredables? ¿Tienen los factores ambientales tempranos consecuencias a largo plazo sobre la cognición? ¿Cuál es la relación entre variabilidad genética y vulnerabilidad cognitiva? ¿Existen vías neurobiológicas específicas para la manifestación de las alteraciones cognitivas en pacientes con esquizofrenia? Estas preguntas se exploran en la presente tesis a partir de análisis basados en muestras de gemelos y en grupos familiares, que constituyen una manera metodológicamente potente de estudiar los efectos de la variabilidad genética y ambiental sobre la cognición humana. En este sentido, la diversidad fenotípica de la esquizofrenia y la cognición humana, lejos de representar un obstáculo para la investigación de su etiología, sienta las bases de modelos complejos que podrían fomentar una comprensión cada vez más completa de los mecanismos de vulnerabilidad y resiliencia posiblemente involucrados en su origen (Belsky, 2011).
Pelayo, Terán José María. "Polimorfismo Val158Met del gen catecol-o-metiltransferasa y características clínicas en primeros episodios de psicosis". Doctoral thesis, Universidad de Cantabria, 2011. http://hdl.handle.net/10803/32201.
Pełny tekst źródłaThe schizophrenia is considered a heterogeneous syndrome which has multifactorial causes, including environmental, characterial and genetic factors. Despite the fact that 50% of the variability of the illness is explained by genetic factors, only a limited number of genetic variants have been identified as weak risk factors. Most of them have not been replicated because of the heterogeneity of the studied samples and the association with other mental illnesses. This variability has been tried to be solved by the use of endophenotypes and biological markers, as indicators of genetic vulnerability. Catechol-O-Methyltransferase gene, that codifies a dopamine degradation enzyme active in prefrontal cortex, has been studied as one of the most promising candidates in the etiopathogenesis of schizophrenia, particularly the rs4860 polymorphism (Val158Met). The possible association with an altered prefrontal dopaminergic transmission would be supported by the revised dopaminergic theory. Following this theory, there is a dopaminergic disequilibrium in schizophrenia, with an increase in subcortical D2 dopaminergic transmission and a deficit in D1 cortical stimulation. COMT Val158Met polymorphism has not consistently associated with schizophrenia. The study of endophenotypes and biological markers has suggested associations with cognitive deficits, neurophysiologic and neuroanatomic markers and with clinical phenotypes, such as aggressiveness, suicide, psychotic symptoms, age of onset and clinical response. It also has been reported an interaction with cannabis in the modulation of the risk of psychosis. This heterogeneity could be explained by methodological biases, related to the validity and representativeness of the studied samples and may be solved with the systematic study of epidemiological samples of patients in the initial phases of psychosis. Following the hypothesis of the existence of an altered prefrontal dopaminergic transmission, the Val158 allele in the COMT gene would be associated with more severe psychotic symptoms, particularly negative symptoms and with poor prognostic factors. Likewise, the premorbid use of cannabis could modulate this risk, increasing the risk or counteract the protective factors. The main objective was to study the association between the clinical onset and evolution in the first 6 weeks of treatment and the COMT Val158Met polymorphism as well as the interaction with premorbid cannabis use. The secondary objectives were to study the incidence of schizophrenia and validate the representativeness of the sample, to analyse the relation between the Val158Met polymorphism and clinical symptoms, age of onset, clinical response to treatment and to estimate the presence of gen-environment interactions with the premorbid cannabis use. 174 consecutive first episode psychosis patients with a diagnosis of schizophrenia, schizoaffective disorder, schizophreniform disorder, brief psychotic disorder or psychosis non-otherwise specified were included in the PAFIP program. The program was designed for the detection and treatment of all cases in the region of Cantabria, form February 2001 to February 2005. The patients were assessed with a semi-structured interview, SANS, SAPS, HDRS, CDS, YMRS scales and the SCID-I interview. They were followed up to 6 weeks and treated with a randomly assigned antipsychotic (olanzapine, risperidone or haloperidol). Rs4680 polymorphism was assessed in peripheric blood samples. A first study showed a treated incidence of 1.38/10000 and the association with several risk factors such as age under 25 years, male gender, single marital status, unemployment, primary educational level, urban environment and cannabis use. A second study found an association between the Val158 allele and negative symptoms severity at onset, early age of onset, schizophrenia diagnosis and longer duration of untreated psychosis in females. A third study showed an association between premorbid cannabis use and early age of onset and an interaction between cannabis use and genotype, indicating that the cannabis use counter act the protective effect of the Met158Met allele in age of onset. Finally, in a fourth study the association between the Val158 allele and negative symptoms was confirmed after 6 weeks of treatment, although no relation was found with clinical response. The results showed that the COMT Val158Met polymorphism could be associated with an earlier age of onset and a higher severity of negative symptoms. Likewise, the premorbid use of cannabis was associated with an earlier age of onset and there was found a gene-environmental interaction, deleting the protective effect of the Met158 Allele. These findings suggest the importance of COMT Val158Met polymorphism and premorbid cannabis use in the etiopathogenesis of the schizophrenia that could be explained by a decrease in the prefrontal dopaminergic transmission.
Denis, Frédéric. "Déterminants et perception de la santé orale des patients schizophrènes en Côte d'Or". Thesis, Bourgogne Franche-Comté, 2017. http://www.theses.fr/2017UBFCE006/document.
Pełny tekst źródłaBackground: Schizophrenia is a disease that affects 1 % of the world population. Persons with schizophrenia (PWS) are exposed to excess morbidity and mortality. Poor oral health among PWS is often observed by caregivers and accompanying persons. The objective of our study was to explore predictive factors, representations and perceptions of oral health among PWS and to construct a specific oral health quality of life scale for PWS.Methods: In a randomly selected, representative sample of 109 PWS in the Côte d’Or Department, we recorded socio-demographic, dental, and medical and lifestyle factors associated with oral health. An evaluation of the psychometric characteristics of the Global Oral Health Assessment Index (GOHAI) scale was also performed, as well as a qualitative study based on semi-directive interviews with 20 PWS and 6 carers. Two focus groups (4 patients and 4 carers) enabled investigation of the perceptions and representations of oral health among PWS and building the first draft prototype of a specific tool to assess oral health quality of life of PWS.Results: Among 109 patients included, 61.5% were male, and average age was 46.8 ± 12.0 years. The majority (78%) had secondary level education and 79.8% received ambulatory care. The mean duration of schizophrenia was 17.9 ± 9.4 years, and 55.5% were taking several medications. The average DMFT (Decayed, Missing, and Filled Teeth) was 16.6 ± 8.1. There was a significant relationship between level of education and oral health, lifestyle, medical conditions, polypharmacy and DMI. Concerning the psychometric validation of the GOHAI, internal consistency was excellent (Cronbach α = 0.82). The intraclass correlation coefficients for test-retest reliability were not significantly different (p> 0.05). Construct validity was supported by three factors which accounted for 60.94% of the variance observed. Predictive and concurrent validity were validated. The qualitative study yielded 3245 candidate verbatims for the development of a new scale, namely the SOHP, Schizophrenia Oral Health Perception Profile. Successive selections of items from the expert panel decision criteria and based on a feasibility study in 30 patients resulted in a scale comprising 43 items and one additional module of 11 items.Conclusion: We show the intricate links existing between mental and physical, oral and general health and the GOHAI validity in PWS. Further research is necessary to validate the psychometric properties of the SOHP scale in a larger population
Revel, Nadine. "Epidémiologie de la schizophrénie : aspects génétiques". Paris 5, 1988. http://www.theses.fr/1988PA05P094.
Pełny tekst źródłaFRANCQ, BRUNO. "Evolution et pronostic de la schizophrenie, son epidemiologie chez les femmes du pas-de-calais en 1955 et 1975". Lille 2, 1988. http://www.theses.fr/1988LIL2M099.
Pełny tekst źródłaNordon, Clémentine. "Etudes pharmaco-épidémiologiques des neuroleptiques chez les sujets âgés et les patients souffrant de schizophrénie". Phd thesis, Université René Descartes - Paris V, 2013. http://tel.archives-ouvertes.fr/tel-00919103.
Pełny tekst źródłaVerdoux, Hélène. "Apports de l'épidémiologie à l'étude des facteurs de risque pour les schizophrénies". Bordeaux 2, 1998. http://www.theses.fr/1998BOR28559.
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