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Rozprawy doktorskie na temat „S100 proteins”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Alwash, Ban Hussein Kadhim. "S100 proteins control cytoskeletal dynamics in cancer." Thesis, University of Leicester, 2018. http://hdl.handle.net/2381/42867.

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The S100 family of calcium binding proteins exhibits a unique pattern of cell type specific expression. These proteins are found in the cytoplasm and/or nucleus of a variety of cells, and involved in the control of a wide range of cellular processes such as cell cycle progression and differentiation. S100A4 and S100A6 are members of the S100 protein family that interact with several molecular targets including the heavy chain of non-muscle myosin IIA (NM IIA) and annexin II, respectively. NM IIA is a major actin-associated motor protein, which is involved in cell motility and cytokinesis. Asse

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Robinson, Matthew James. "An investigation into the function of two S100 proteins, S100 A12 and MRP-14." Thesis, University College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.394031.

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Newton, Rebecca Anne. "A role for S100 proteins in leukocyte adhesion." Thesis, University College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298801.

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Al, Ismaeel Qais Ibraheem. "Regulation and function of S100 proteins in pancreatic carcinoma." Thesis, University of Leicester, 2017. http://hdl.handle.net/2381/40889.

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Pancreatic cancer (PC) is one of the leading causes of cancer-related death worldwide with the survival rate less than 5% because of late diagnosis. Development of PC is complex, it is promoted by the tumour microenvironment and often accompanied by inflammation. Epithelial mesenchymal transition (EMT) is an embryonic genetic program reactivated in cancer. EMT is implicated in the escape from senescence, tumour cell invasiveness, cancer metastasis, and drug resistance. EMT encompasses global reorganisation of the gene expression profiles, loss of epithelial markers and activation of mesenchyma

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5

Wheeler, Lucas. "The Evolution of Metal and Peptide Binding in the S100 Protein Family." Thesis, University of Oregon, 2018. http://hdl.handle.net/1794/23178.

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Proteins perform an incredible array of functions facilitated by a diverse set of biochemical properties. Changing these properties is an essential molecular mechanism of evolutionary change, with major questions in protein evolution surrounding this topic. How do new functional biochemical features evolve? How do proteins change following gene duplication events? I used the S100 protein family as a model to probe these aspects of protein evolution. The S100s are signaling proteins that play a diverse range of biological roles binding Calcium ions, transition metal ions, and other prote

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6

Brant, Stephen. "Distribution of renal S100 proteins in physiological and pathological models." Thesis, University of East London, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342101.

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Turnier, Jessica L. M. D. "Urine S100 Proteins as Potential Biomarkers of Lupus Nephritis Activity." University of Cincinnati / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1491308278173071.

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Goyette, Jesse Davis Medical Sciences Faculty of Medicine UNSW. "The extracellular functions of S100A12." Publisher:University of New South Wales. Medical Sciences, 2008. http://handle.unsw.edu.au/1959.4/41302.

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The S100s comprise a group of Ca2+-binding proteins of the EF-hand superfamily with varied functions. Within this family, three inflammatory-related proteins - S100A8, S100A9 and S100A12 - form a subcluster known as the 'calgranulins'. S100A12 levels are elevated in sera from patients with inflammatory diseases, such as rheumatoid arthritis and inflammatory bowel disease. S100A12 is constitutively expressed in neutrophils and induced in monocytes by LPS and TNFα, and in macrophages by IL-6. S100A12 is a potent monocyte and mast cell chemoattractant and its potentiation of mast cell activation

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Rahimi, Ahmed Farid Medical Sciences Faculty of Medicine UNSW. "Regulation of inflammation-associated S100 proteins in fibroblasts and their expression in atherosclerosis." Awarded by:University of New South Wales. School of Medical Sciences, 2004. http://handle.unsw.edu.au/1959.4/20503.

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The multigene family of Ca2+-binding S100 proteins comprises 22 members that have various important intra- and extracellular roles. The three inflammation-associated members of this family???S100A8, S100A9 and S100A12 (collectively termed &quotcalgranulins&quot)???are constitutive neutrophil and monocyte proteins also expressed by macrophages within acute and chronic inflammatory lesions, but not in tissue macrophages. They are expressed in human/murine wounds and by appropriately activated macrophages, microvascular endothelial cells and keratinocytes in vitro. The &quot calgranulins&quot are

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Cunden, Lisa Stephanie. "A molecular investigation of the antimicrobial functions of the human S100 host-defense proteins." Thesis, Massachusetts Institute of Technology, 2019. https://hdl.handle.net/1721.1/121779.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemistry, 2019<br>Cataloged from PDF version of thesis. Vita.<br>Includes bibliographical references.<br>The human host is continually exposed to potentially harmful organisms and the innate immune response is the first line of defense against microbial invasion. One strategy employed by the human innate immune system includes the release of antimicrobial host-defense proteins (HDPs). The goal of this thesis is to understand the antimicrobial functions of four host-defense proteins of the S100 family of proteins: calprotecti

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May, Richard David. "An investigation into the function of two murine S100 proteins, MRP-8 and MRP-14." Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313789.

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Aljaberi, Najla. "The use of S100 proteins testing in juvenile idiopathic arthritis and autoinflammatory diseases in a pediatric clinical setting: a retrospective analysis." University of Cincinnati / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1584000950963649.

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Joseph, Robiya [Verfasser], and Johannes [Akademischer Betreuer] Roth. "The role of S100 proteins (MRP8, MRP14) in cellular dynamics of phagocytes / Robiya Joseph. Betreuer: Johannes Roth." Münster : Universitäts- und Landesbibliothek der Westfälischen Wilhelms-Universität, 2012. http://d-nb.info/1027021360/34.

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Kawata, Keisuke. "SUBCONCUSSIVE HEAD IMPACT EFFECT ON PLASMA EXPRESSION OF S100-BETA AND PINCH PROTEINS IN COLLEGIATE FOOTBALL PLAYERS." Diss., Temple University Libraries, 2016. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/398688.

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Kinesiology<br>Ph.D.<br>In this prospective longitudinal investigation of Division-I collegiate football players, the acute and longer-term effects of repetitive subconcussive impacts on plasma S100β and PINCH levels and concussion-related symptom score were examined. The first aim was to investigate the acute repetitive subconcussive impact effect by comparing the biomarker levels at pre and post full-gear practice, followed by examining the relationship of head impact magnitude and frequency of on acute increases in S100β and PINCH levels and symptom score. Hypotheses for the first aim were

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Al-Medhtiy, M. H. "The relationship between metastasis-inducing S100 proteins (MIPs) and matrix metalloproteinases (MMPs) in rat and human breast cancer." Thesis, University of Liverpool, 2018. http://livrepository.liverpool.ac.uk/3025851/.

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Okada, Kouki. "CD68 on rat macrophages binds tightly to S100A8 and S100A9 and helps to regulate the cells’ immune functions." 京都大学 (Kyoto University), 2017. http://hdl.handle.net/2433/225517.

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Cunha, Jinger do Carmo. "Estudo da imunorreatividade das proteínas ligantes de cálcio na neuroquímica da medula espinal de ratos submetidos à atividade física espotânea na roda de corrida." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/47/47135/tde-15012009-145617/.

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As ações da atividade física na neuroquímica dos neurônios, com enfoque às proteínas ligantes de cálcio (Ca2+), e o estado de ativação de células gliais da medula espinal do rato foram investigadas em preparados imuno-histoquímicos através da análise morfométrica e microdensitométrica com auxílio do computador. Ratos machos adultos foram divididos em dois grupos: treinado, cujos animais foram expostos à roda de corrida onde realizava atividade física espontânea, por um período de 4 e 14 noites; e sedentário, onde os animais foram mantidos em caixas individualizadas, sem a roda de corrida. Após

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18

Wild, Katharina [Verfasser], and Friedrich [Akademischer Betreuer] Paulsen. "Expression und Regulation des S100 fused-type Proteins Hornerin an der Augenoberfläche des Menschen / Katharina Wild. Gutachter: Friedrich Paulsen." Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2014. http://d-nb.info/1075835003/34.

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Reinhardt, Katharina [Verfasser], and Ursula [Akademischer Betreuer] Holzer. "Role of monocyte-induced development of Th17 cells, the heat shock protein 90 and proinflammatory S100 proteins in the pathogenesis of graft-versus-host disease / Katharina Reinhardt ; Betreuer: Ursula Holzer." Tübingen : Universitätsbibliothek Tübingen, 2015. http://d-nb.info/1196982422/34.

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Lundin, Anders. "Mild traumatic brain injury : clinical course and prognostic factors for postconcussional disorder/." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-078-7/.

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Hoppmann, Susan. "18F-markierte S100-Proteine als potentielle Radioliganden für die funktionelle Charakterisierung des Rezeptors für advanced glycation endproducts (RAGE) in vitro und in vivo." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2009. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-24725.

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Die Interaktion von S100-Proteinen mit dem Rezeptor für advanced glycation endproducts (RAGE) wird als hoch relevant bei der Entstehung, Manifestation und Progression verschiedener entzündlicher Erkrankungen sowie bei der Tumorigenese gewertet. Das tiefergehende Verständnis der Interaktion von S100-Proteinen mit RAGE in vivo stellt eine wissenschaftliche Herausforderung dar und ist ein Ansatz für therapeutische Interventionen. Darüber hinaus stellen Untersuchungen zum Metabolismus von extrazellulär zirkulierenden S100-Proteinen in vivo einen vielversprechenden Forschungsansatz zur Analyse von

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Wilhelm, Kristina Rebecca. "Protein complexes assembly, structure and function /." Umeå : Umeå university, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-29792.

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Souza, Jean Jorge Silva de. "Identificação de fatores diabetogênicos associados ao adenocarcinoma de pâncreas." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/5/5135/tde-30102006-152027/.

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Diabetes melito ou intolerância à glicose estão presentes em até 80% dos pacientes com adenocarcinoma de pâncreas. Portadores desta neoplasia têm resistência à insulina e alteração na secreção de insulina em resposta à glicose, o que pode levar ao aparecimento ou piora de diabetes. Para identificar genes diferencialmente expressos, que podem representar fatores diabetogênicos produzidos pelo adenocarcinoma de pâncreas, utilizou-se a comparação de microarranjos de oligonucleotídeos hibridizados com RNA complementar (cRNA) de tumores pancreáticos de pacientes com e sem diabetes melito no pré-op

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Nygren, de Boussard Catharina. "Studies on head trauma complications : with special reference to mild traumatic brain injury /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-836-X/.

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Svenmarker, Staffan. "Heparin coating and cardiotomy suction in cardiopulmonary bypass." Doctoral thesis, Umeå : Univ, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-134.

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Pekkala, N. (Niina). "S100B-proteiini lasten kuumekouristuksissa." University of Oulu, 2014. http://urn.fi/URN:NBN:fi:oulu-201412162129.

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S100B-proteiini on gliasoluspesifinen proteiini, jota vapautuu verenkiertoon aivovaurioiden yhteydessä. Kohonneet pitoisuudet korreloivat aivovaurion vaikeusasteen ja lopputuleman kanssa. S100B-proteiini toimii myös merkkiaineena veri—aivoesteen toimintahäiriöille. Lapsilla kohonneet proteiinipitoisuudet on liitetty astrosyyttivaurion markkereiksi jopa lievän aivovamman jälkeen. On mahdollista, että kuumekouristusten yhteydessä seerumin ja likvorin S100B-proteiinipitoisuudet nousevat ollen merkkinä aivoissa käynnissä olevasta patologisesta prosessista ja ennustavat kohtausten uusiutumistodennä

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Réty, Stéphane. "Bases structurales de l'interaction entre les proteines s100 et les annexines." Paris 11, 1998. http://www.theses.fr/1998PA112281.

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Les annexines (ax) sont des proteines liant les phospholipides charges negativement en presence de ca2+ et impliquees dans des processus de transport membranaire comme les phenomenes d'agregation precedant la fusion des membranes. Plusieurs annexines peuvent s'associer avec des membres de la famille des proteines s100, petites proteines de 10 kd de poids moleculaire formees d'une paire de mains ef, un motif de liaison au ca2+ en helice-boucle-helice. Ainsi, l'annexine i se lie a la s100c en presence de ca2+ et l'annexine ii a la p11. Cette derniere est insensible au ca2+. Les proteines s100 fo

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Abraha, Hagosa Demoz. "Clinical applications of circulating S100B protein." Thesis, King's College London (University of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.426060.

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Niven, Jennifer A. "The role of S100B in retinal inflammation." Thesis, University of Aberdeen, 2013. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=202787.

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S100B is a member of the S100 calcium binding protein family and is highly expressed within astrocytes in the brain. Elevated levels of S100B are associated with brain and central nervous system disorders, due to the breakdown of the blood brain barrier. Therefore S100B is routinely used as a marker of disease. Traditionally S100B was thought only as a cell breakdown product but increasing evidence suggests that it may play a role in exacerbating inflammation, however this role is not clear. S100B is known to be present within the eye but its role in retinal inflammation has not been investiga

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McDowell, Chester Dale. "Potential heterogeneity in p53/S100B(ββ) complex". Thesis, Kansas State University, 2012. http://hdl.handle.net/2097/13845.

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Master of Science<br>Department of Biochemistry<br>Jianhan Chen<br>Paul E. Smith<br>Intrinsically disordered proteins have been shown to be important in many physiological processes, including cell signaling, translation, and transcription. They are also associated with cancer, and neurodegenerative diseases. The tumor suppressor p53 contains several disordered regions, including the C-terminal negative regulatory domain (NRD). In cancer the function of p53 has been shown to be repressed by S100B(ββ) binding to p53-NRD. Binding of S100B(ββ) blocks acetylation and phosphorylation sites in the p

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Stålnacke, Britt-Marie. "Detection and outcome of mild traumatic brain injury in patients and sportsmen : persisting symptoms, disabilities and life satisfaction in relation to S-100B, NSE and cortisol." Doctoral thesis, Umeå universitet, Institutionen för samhällsmedicin och rehabilitering, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-259.

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Traumatic brain injuries are common (hospitalization incidence: 250-300 per 100.000 inhabitants/year) and a great majority of these injuries (80-85%) are classified as mild traumatic brain injury (MTBI/concussion). Many patients with MTBI (20-80%) suffer from subsequent persistent and often disabling symptoms. In previous studies serum levels of biochemical markers of brain tissue damage (S-100B and neuron-specific enolase, NSE) have been propounded to serve as predictors of persisting symptoms.In the present studies serum concentrations of S-100B, NSE and cortisol in acute phase and post-conc

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Ilschner, Maud. "Diagnostische Wertigkeit von Protein S100 und Neuronenspezifischer Enolase bei Patienten mit spontaner Subarachnoidalblutung." kostenfrei, 2008. http://www.opus-bayern.de/uni-regensburg/volltexte/2009/1209/.

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Stoll, Alexander. "Neurologische Komplikationen nach Herzoperationen unter der Berücksichtigung der Hypoxiemarker NSE und Protein S100 /." Hamburg : Akademos Wiss.-Verl, 2003. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=010456703&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.

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Irvine, Andrew Francis. "Characterising the interaction between metastasis-associated protein S100A4 and non-muscle myosin IIA in vitro and in vivo." Thesis, University of Leicester, 2012. http://hdl.handle.net/2381/27622.

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S100A4 is a member of the S100 family of proteins and increases the motility of many cell types. This is also thought to explain its association with the epithelial-mesenchymal transition (EMT), a developmental program re-activated during tumourigenesis. Mechanistically, S100A4 interacts with a number of targets including Smad3 and liprin-β1; however, the best characterised is non-muscle myosin IIA (NMIIA) which regulates many aspects of the cytoskeleton. There is a large body of in vitro data indicating that S100A4 promotes the monomeric state of NMIIA; however, in vivo evidence for the inter

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Smith, Steven P. "Calcium-induced structural changes in human S100B protein." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq31131.pdf.

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Tramontina, Francine. "Efeito do glutamato, serotonina e fluoxetina sobre a secreção da proteína S100B e seu efeito sobre a captação de glutamato em cultura primária de astrócitos hipocampais." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2006. http://hdl.handle.net/10183/8612.

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A S100B é uma proteína ligante de cálcio produzida e secretada por astrócitos e tem sido relacionada à interação neurônio-glia. Nosso primeiro objetivo foi investigar um possível efeito autócrino da S100B na captação de glutamato. A utilização do anticorpo anti-S100B reduziu a captação de glutamato após 30 minutos de incubação, sem afetar a integridade e viabilidade celular. Além disso, baixas concentrações de S100B (menos de 0,1 ng/mL) estimularam a captação de glutamato avaliada imediatamente após a troca de meio. Este dado reforça a importância dos astrócitos na transmissão glutamatérgica,

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Camara, Ramatoulie. "Design, synthesis and biological evaluation of potential inhibitors of S100P, a protein implicated in pancreatic cancer." Thesis, University of Hertfordshire, 2015. http://hdl.handle.net/2299/17117.

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Pancreatic cancer is relatively uncommon. Despite its relative scarcity, it is the fourth-ranked cancer killer in the Western world with less than a 5% 5-year survival rate. The high mortality rate is due to the asymptomatic nature of the disease and the advanced stage at which it is usually diagnosed. S100P is a calcium-binding protein that has been shown to be highly expressed in the early stages of pancreatic cancer and has been proposed as a potential therapeutic target via the blocking of its interaction with its receptor RAGE, the receptor for advanced glycation end-products. In this the

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Karkow, Ana Raquel Menezes. "Efeitos da estimulação neonatal sobre a expressão das proteínas S100B e GFAP no locus coeruleus, córtex frontal e bulbo olfatório de ratos machos e fêmeas." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2007. http://hdl.handle.net/10183/13225.

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A estimulação neonatal ocasiona alterações no desenvolvimento neuroendócrino, morfológico e comportamental de ratos. O procedimento de manipulação neonatal promove uma ruptura na relação mãe-filhote que pode perturbar o desenvolvimento do SNC. Uma das alterações morfológicas apresentadas em ratos machos e fêmeas manipulados no período neonatal é a diminuição do número de neurônios no locus coeruleus. A S100B é uma proteína ligante de cálcio secretada por astrócitos que pode apresentar ações extracelulares neurotróficos e neurotóxicas. Diversos estudos relacionam alterações dos níveis de S100B

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Grote, Stephanie. "Expression der S100-Proteine MRP8 und MRP14 und Einfluss auf die Differenzierung von embryonalen Stammzellen zu Makrophagen." [S.l. : s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=967441358.

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Abdul-Khaliq, Hashim. "Untersuchungen zur Entwicklung neuroprotektiver Strategien bei operativer Behandlung angeborener Herzfehler." Doctoral thesis, [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=965628493.

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Ulrich, Anett. "S100B-Protein und Neuronenspezifische Enolase bei leichten Schädel-Hirn-Verletzungen im Kindesalter." Doctoral thesis, Universitätsbibliothek Leipzig, 2011. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-63800.

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Fragestellung: Gegenstand dieser Untersuchung ist der diagnostische Nutzen der Neuro-Biomarker S100B-Protein und Neuronenspezifische Enolase (NSE) bei leichten Schädel-Hirn-Verletzungen im Kindesalter. Es wird untersucht, ob anhand der posttraumatischen S100B- und NSE-Serum-Konzentrationen Kinder mit einer Schädelprellung und einem leichten Schädel-Hirn-Trauma (SHT) differenziert werden können. Material und Methode: In einer prospektiven, klinischen Studie werden die posttraumatischen S100B- und NSE-Serum-Konzentrationen von Kindern im Alter zwischen 6 Monaten und 15 Jahren mit einer Schädelp

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Hansel, Gisele. "Avaliação de parâmetros neuroquímicos em fatias de hipocampo de rato submetidas à privação de oxigênio e glicose." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2009. http://hdl.handle.net/10183/21425.

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Mesmo a isquemia sendo a terceira causa de morte em países industrializados, os mecanismos relacionados a esta doença ainda continuam polêmicos e obscuros. Utilizou-se a técnica de privação de oxigênio e glicose (OGD) em fatias do hipocampo de rato para investigar parâmetros mitocondriais, neurais, astrogliais e metabólicos no período de isquemia e durante o período de reoxigenação. Os resultados mostraram uma diminuição na atividade mitocondrial durante o período isquêmico que foi mantido durante todo o período de reoxigenação. Analisando o sobrenadante destas fatias submetidas à OGD, foi obs

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Campos, Leila Maria Guissoni. "Estudo da distribuição da proteína S100b em encéfalo de ratos." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/42/42131/tde-29012008-145258/.

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A proteína S100<font face=\"symbol\">b no cérebro é produzida e secretada pela célula da glia astrócito, e exerce de acordo com sua quantidade extracelular, ação trófica ou tóxica sobre os neurônios. Investigamos a distribuição da proteína S100<font face=\"symbol\">b, no animal em condição basal, realizando o mapeamento em diferentes áreas do encéfalo, com a técnica imuno-histoquímica, explorando a hipótese do aparecimento de S100<font face=\"symbol\">b em áreas encefálicas preferenciais. A distribuição da proteína foi analisada pela técnica do imuno-histoquímica, com utilização de anticorpo a

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Tolmie, Helen. "Isolation of S100B from the cytosol of a T lymphocyte cell line : identification of receptor proteins." Thesis, Liverpool John Moores University, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.247725.

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Willumeit, Regine. "Lokalisierung der Proteine L1, S6 und S10 des E.-coli-Ribosoms mit spinabhängiger Neutronenkleinwinkelstreuung /." Geesthacht : GKSS, 1996. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=007390140&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.

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Mély, Yves. "Proprietes de la proteine s100b : purification d'isoproteines, formation de ponts disulfure, etude d'un derive disulfure mixte." Université Louis Pasteur (Strasbourg) (1971-2008), 1988. http://www.theses.fr/1988STR13164.

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Leke, Renata. "Neurotoxicidade do metotrexato : utilização da proteína S100B como um marcador e estudo do envolvimento do sistema glutamatérgico." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2005. http://hdl.handle.net/10183/4941.

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O metotrexato (MTX) é um antagonista do ácido fólico amplamente utilizado no tratamento de doenças neoplásicas e não neoplásicas. Entretanto, o uso terapêutico desse fármaco pode levar à neurotoxicidade que pode se manifestar na forma aguda, subaguda e crônica, abrangendo os seguintes sintomas: cefaléia, sonolência, confusão, edema cerebral, convulsões, encefalopatia, coma e prejuízo das funções cognitivas. Os achados neuropatológicos consistem de astrogliose reativa, desmielinização, dano axonal e necrose da substância branca. Em nível celular, o MTX parece afetar primeira e seletivamente os

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Deye, Nicolas. "Cardiac Arrest-Induced Brain Injury : Diagnostic And Prognostic Values of Circulating Biomarkers." Thesis, Sorbonne Paris Cité, 2018. http://www.theses.fr/2018USPCC150.

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Le pronostic de l’arrêt cardiaque (AC) reste dramatique. Diagnostiquer sa cause rapidement et prédire précocement son pronostic ("pronostication") de manière fiable permettrait de mieux guider les traitements initiaux, en évitant de traiter futilement les patients avec faible probabilité d’évolution favorable ou à l’inverse de permettre d’intensifier le traitement de patients avec forte probabilité d’évolution favorable. Les biomarqueurs, dont l’utilité diagnostique et pronostique reste débattue, semblent actuellement insuffisamment sensibles et précis, surtout dans les 1ères heures après la r

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Perera, Rehani Shinuka. "Determining the Structural Dynamics and Topology of Canonical HOLIN-S05 Using EPR Spectroscopy." Miami University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=miami1591797430542798.

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Dellagrammaticas, Demosthenes. "Cerebral haemodynamic control and carotid endarterectomy : comparison of general and locoregional anaesthesia." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/cerebral-haemodynamic-control-and-carotid-endarterectomy-comparison-of-general-and-locoregional-anaesthesia(a7b50cfa-d56d-40ff-b8d8-dbc1a2ff105e).html.

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The role of CEA for stroke prevention in the presence of symptomatic carotid artery stenosis is well established. In order to maximize the benefit of surgery, several perioperative processes of care have been under scrutiny, of which one is the choice of anaesthetic method. The differing effects of GA vs. LA on the cerebral circulation after CEA may be of significance, since changes in the cerebral circulation post-CEA may give rise to cerebral hyperperfusion and intracerebral haemorrhage. This work assessed the effect of GA vs. LA on cerebral haemodynamic control after CEA using transcranial

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