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Crombie, Catriona Ann. "Histone hairpin binding protein, an RNA binding protein, essential for development". Thesis, University of Aberdeen, 2003. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU602058.
Pełny tekst źródłaZhong, Jun. "A double-stranded RNA binding protein that is important for murine spermatogenesis and growth /". Thesis, Connect to this title online; UW restricted, 1999. http://hdl.handle.net/1773/10301.
Pełny tekst źródłaKok, Kin-hang. "Roles of human double-stranded RNA binding proteins TRBP and PACT in RNA interference". Click to view the E-thesis via HKUTO, 2006. http://sunzi.lib.hku.hk/hkuto/record/B38523218.
Pełny tekst źródłaKok, Kin-hang, i 郭健恆. "Roles of human double-stranded RNA binding proteins TRBP and PACT in RNA interference". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B38523218.
Pełny tekst źródłaPrichard, Lisa. "The role of the IQ motif, a protein kinase C and calmodulin regulatory domain, in neuroplasticity, RNA processing, and RNA metabolism /". Thesis, Connect to this title online; UW restricted, 1998. http://hdl.handle.net/1773/6302.
Pełny tekst źródłaLoushin, Newman Carrie Lee. "Characterization of QKI RNA binding function /". Full text (PDF) from UMI/Dissertation Abstracts International, 2000. http://wwwlib.umi.com/cr/utexas/fullcit?p3004323.
Pełny tekst źródłaDavies, Holly Gibs. "MSY4, a sequence-specific RNA binding protein expressed during mouse spermatogenesis /". Thesis, Connect to this title online; UW restricted, 2000. http://hdl.handle.net/1773/10307.
Pełny tekst źródłaWolf, Joshua Jaeger. "Post-transcriptional coordination by an RNA-binding protein". Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/57893.
Pełny tekst źródłaCataloged from PDF version of thesis.
Includes bibliographical references.
RNA-binding proteins can regulate the stability, localization, and translation of their target mRNAs. Post-transcriptional regulation can orchestrate dynamic changes in gene expression, and can coordinate multiple cellular processes in response to various stimuli. Filamentous growth in Saccharomyces cerevisiae is a morphogenetic switch that occurs in response to nitrogen starvation and requires alterations in cell growth, cell cycle, and cell wall functions. Tyl element retrotransposition is also induced under conditions of nitrogen starvation. I describe a role for the RNA-binding protein Khdl in regulating these two responses to environmental stress through its mRNA targets. I identified the RNA targets of Khdl using in vivo crosslinking and immunoprecipitation (CLIP), combined with deep sequencing. This produced a high-resolution map of Khdl binding sites across the transcriptome, and provided unprecedented insight into its biological functions. Khdl regulates multiple post-transcriptional regulatory loops to coordinate the components of filamentous growth and Tyl retrotransposition. Although similar mechanisms were known to transcriptionally regulate these processes, the posttranscriptional coordination is a novel discovery. The feed-forward regulation that Khdl confers on FLO11, which encodes a protein required for filamentous growth, enables asymmetric expression between mother and daughter cells to switch between filamentous and yeast form growth. In this thesis, I describe regulation of gene expression by RNA-binding proteins, methods to identify their target transcripts and recognition sequences, the KH domain, known functions of Khdl, and the phenotypes it coordinates. My work represents the first application of CLIP to budding yeast, and the growing understanding of RNA-binding proteins in this organism facilitated the placement of Khdl into its posttranscriptional regulatory network. While many questions remain regarding the role Khdl plays in regulating cellular activities, this thesis addresses its direct role in key processes.
by Joshua Jaeger Wolf.
Ph.D.
Zinnall, Ulrike. "Functional characterization of the RNA-binding protein HDLBP". Doctoral thesis, Humboldt-Universität zu Berlin, 2021. http://dx.doi.org/10.18452/23301.
Pełny tekst źródłaThe secretory pathway is essential for proper cell functioning and starts when mRNAs encoding membrane and secretory proteins are targeted to the endoplasmic reticulum (ER). However, little is known about the contribution of RNA-binding proteins to the recognition, localization and translation of ER-localized mRNAs. In this work, we characterized the human RNA-binding protein HDLBP. We identified that HDLBP binds to more than 80% of all ER-localized mRNAs by PAR-CLIP, cell fractionation and RNA-sequencing experiments. Analysis of the HDLBP binding motif showed that it predominantly binds to a CU-containing motif and forms high affinity multivalent interactions primarily in the coding sequence (CDS) of ER-localized mRNAs. In contrast, we identified that cytosolic HDLBP mRNA targets show less HDLBP binding sites randomly distributed between the CDS or 3’ untranslated regions. This indicates that ER-localized mRNAs per se differ from cytosol-localized mRNAs in their sequence composition with regard to HDLBP binding sites. Further PAR-CLIP analysis revealed that HDLBP interacts with RNA components of the signal recognition particle (SRP) and the 40S ribosomal subunit. We identified by BioID experiments proteins in close proximity to HDLBP and confirmed the association of HDLBP with components of the translational apparatus and the SRP. Functional studies using CRISPR-Cas9 HDLBP knockout (KO) cell lines in combination with ribosome profiling demonstrated that HDLBP promotes the translation of its ER-localized target mRNAs. We validated this finding by pSILAC experiments and detected the corresponding decrease in protein synthesis of proteins encoded by mRNAs that are bound by HDLBP and ER-localized. Lastly, in vivo experiments with nude mice showed that HDLBP KO resulted in a decrease of lung tumor formation highlighting the relevance of HDLBP for tumor progression. Overall, these results demonstrate a general function for HDLBP in the translation of ER-localized mRNAs.
Moro, Alberto Maria. "Functional characterization of the RNA binding protein RALY". Doctoral thesis, University of Trento, 2013. http://eprints-phd.biblio.unitn.it/1086/1/Albertomaria_Moro_thesis_Final_version.pdf.
Pełny tekst źródłaNashchekin, Dmitri. "A Y-box protein/RNA helicase complex links mRNP assembly on the gene to mRNA translation /". Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-811-8/.
Pełny tekst źródłaCass, Danielle Marie. "Role of two RNA binding properties in pre-mRNA splicing /". view abstract or download file of text, 2007. http://proquest.umi.com/pqdweb?did=1400950811&sid=2&Fmt=2&clientId=11238&RQT=309&VName=PQD.
Pełny tekst źródłaTypescript. Includes vita and abstract. Includes bibliographical references (leaves 67-80). Also available for download via the World Wide Web; free to University of Oregon users.
Giorgini, Flaviano. "Functional analysis of the murine sequence-specific RNA binding protein MSY4 /". Thesis, Connect to this title online; UW restricted, 2002. http://hdl.handle.net/1773/10293.
Pełny tekst źródłaSidiqi, Mahjooba. "The structure and RNA-binding of poly (C) protein 1". University of Western Australia. School of Biomedical, Biomolecular and Chemical Sciences, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0077.
Pełny tekst źródłaGarrey, Stephen M. "Characterization of the specificity and affinity of the splicing factor BBP/SF1 /". view abstract or download file of text, 2007. http://proquest.umi.com/pqdweb?did=1324375731&sid=2&Fmt=2&clientId=11238&RQT=309&VName=PQD.
Pełny tekst źródłaTypescript. Includes vita and abstract. Includes bibliographical references (leaves 81-88). Also available for download via the World Wide Web; free to University of Oregon users.
Kylberg, Karin. "Transcription and transport of a messenger RNP particle : novel regulatory mechanisms /". Stockholm : Karolinska institutet, 2007. http://diss.kib.ki.se/2007/978-91-7357-318-4/.
Pełny tekst źródłaWhittington, Christi Leigh. "Molecular Dynamics of the RNA Binding Cavity of Influenza A Non-structural Protein 1 (NS1) RNA Binding Domain". Scholar Commons, 2012. http://scholarcommons.usf.edu/etd/4256.
Pełny tekst źródłaChoudury, Sarah G. Choudury. "Identification and characterization of proteins required for RNA-directed DNA Methylation, including the RNA binding protein ALY1". The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1543508792612526.
Pełny tekst źródłaHuang, Ching-jung. "The role of HnRNP proteins, PSF and nonO/p54[superscript nrb], in pre-mRNA binding and splicing /". Full text (PDF) from UMI/Dissertation Abstracts International, 2000. http://wwwlib.umi.com/cr/utexas/fullcit?p3004292.
Pełny tekst źródłaMaitra, Sushmit. "The AU-rich element mRNA decay-promoting activity of BRF1 is regulated by mitogen-activated protein kinase activated protein kinase 2". Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2008. https://www.mhsl.uab.edu/dt/2008r/maitra.pdf.
Pełny tekst źródłaPark, Youngwoo. "Selective translation of influenza viral messenger RNAs mediated by trans-acting factor(s) through an interaction with the sequence element in the 5'-untranslated region /". Thesis, Connect to this title online; UW restricted, 1999. http://hdl.handle.net/1773/11496.
Pełny tekst źródłaHenscheid, Kristy L. "Functional conservation and RNA binding of the pre-mRNA splicing factor U2AF65 /". view abstract or download file of text, 2007. http://proquest.umi.com/pqdweb?did=1400950821&sid=5&Fmt=2&clientId=11238&RQT=309&VName=PQD.
Pełny tekst źródłaTypescript. Includes vita and abstract. Includes bibliographical references (leaves 129-141). Also available for download via the World Wide Web; free to University of Oregon users.
Öhrmalm, Christina. "Functional characterization of the cellular protein p32 : a protein regulating adenovirus transcription and splicing through targeting of phosphorylation /". Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6794.
Pełny tekst źródłaDurie, Danielle. "RNA Binding Protein HuR Regulates the Expression of Bcl-xL". Thèse, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/23206.
Pełny tekst źródłaSpellman, Rachel Claudine Helen. "Investigation of polypyrimidine tract binding protein function by RNA interference". Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.614210.
Pełny tekst źródłaZinnall, Ulrike [Verfasser]. "Functional characterization of the RNA-binding protein HDLBP / Ulrike Zinnall". Berlin : Humboldt-Universität zu Berlin, 2021. http://d-nb.info/1241116946/34.
Pełny tekst źródłaBourdeau-Julien, Isabelle. "ALS-associated RNA-binding protein FUS and mRNA translation regulation". Master's thesis, Université Laval, 2020. http://hdl.handle.net/20.500.11794/68742.
Pełny tekst źródłaMutations in several genes have been linked to amyotrophic lateral sclerosis (ALS),particularly in the gene coding for the Fused in Sarcoma protein (FUS). Those mutations are found in the part encoding for the nuclear localization signal, making the protein abnormallyabundant in the cytoplasm. Combined with other observations, it suggests that a toxic gainof function of FUS in the cytoplasm would be the cause of the neurodegeneration. ALS is a neurodegenerative disease that affects motor neurons and causes progressive paralysis. The molecular mechanisms causing the disease are still unknown. One of the hypotheses is the disruption of local translation of mRNAs, which allows synapses to respond quickly and independently from the cell body. Insufficient local translation to support long-term synapticactivity would lead to synaptic loss and neurodegeneration. Thereby, the objective of mystudy is to determine the role of FUS in the regulation of mRNA translation by characterizing its interaction with translational components and evaluate its function in an ALS-linked condition. I have shown that FUS is associated with stalled polyribosomes, which suggests that it plays a role in regulating mRNA translation by interacting with the core of translation.There is also an increase in the presence of FUS in the cytoplasm and in its interaction with polyribosomes following inhibition of translation through mTOR, suggesting its role as anegative regulator. In addition, ALS-related mutations amplify FUS inhibitory function bymaking FUS cytoplasmic and reducing protein synthesis. My results show that the FUSprotein would have a role as a translation inhibitor when it is cytoplasmic. There fore, increasing the presence of FUS in the cytoplasm in ALS would result in significant translation inhibition, at a level insufficient to support synaptic activity.
Lal, Preet. "Characterization of Small Molecules Inhibiting the RNA Binding Protein HuR". Doctoral thesis, Università degli studi di Trento, 2017. https://hdl.handle.net/11572/368442.
Pełny tekst źródłaLal, Preet. "Characterization of Small Molecules Inhibiting the RNA Binding Protein HuR". Doctoral thesis, University of Trento, 2017. http://eprints-phd.biblio.unitn.it/2717/1/PhD_thesis_Lal_Preet.pdf.
Pełny tekst źródłaSALADINO, Patrizia. "ROLE OF RNA BINDING PROTEIN IN THE NERVE CELL DIFFERENTIATION". Doctoral thesis, Università degli Studi di Palermo, 2014. http://hdl.handle.net/10447/91214.
Pełny tekst źródłaDwyer, Holly. "Characterization of putative Porphyromonas gingivalis RNA-binding proteins". VCU Scholars Compass, 2014. http://scholarscompass.vcu.edu/etd/3550.
Pełny tekst źródłaHowe, Peter W. A. "NMR studies of the RNA binding domain of U1A protein and its complexes with RNA". Thesis, University of Cambridge, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313879.
Pełny tekst źródłaLee, Sang C., Jack Zhang, Josh Strom, Danzhou Yang, Thai Nho Dinh, Kyle Kappeler i Qin M. Chen. "G-Quadruplex in the NRF2 mRNA 5′ Untranslated Region Regulates De Novo NRF2 Protein Translation under Oxidative Stress". AMER SOC MICROBIOLOGY, 2017. http://hdl.handle.net/10150/622753.
Pełny tekst źródłaIwaoka, Ryo. "Structural basis for translational regulation by RNA-binding protein Musashi-1". Kyoto University, 2017. http://hdl.handle.net/2433/227652.
Pełny tekst źródłaValeiras, Brenda. "Probing RNA binding specificities of AID/APOBEC proteins by iCLIP". Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/288562.
Pełny tekst źródłaÓ, Catnaigh Pól. "An investigation into the RNA-binding protein UNR and its interactors". Thesis, University of Warwick, 2016. http://wrap.warwick.ac.uk/91504/.
Pełny tekst źródłaGit, Anna. "Studies of the expression and function of Vg1 RNA binding protein". Thesis, University of Cambridge, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.620990.
Pełny tekst źródłaCulley, Rachel Louise. "The role of the RNA binding protein FUS in androgen signalling". Thesis, Imperial College London, 2012. http://hdl.handle.net/10044/1/14613.
Pełny tekst źródłaLivi, Carmen Maria. "Protein-dependent prediction of messenger RNA binding using Support Vector Machines". Doctoral thesis, Università degli studi di Trento, 2013. https://hdl.handle.net/11572/369261.
Pełny tekst źródłaLivi, Carmen Maria. "Protein-dependent prediction of messenger RNA binding using Support Vector Machines". Doctoral thesis, University of Trento, 2013. http://eprints-phd.biblio.unitn.it/995/1/phd-thesisLivi.pdf.
Pełny tekst źródłaAudano, M. "THE RNA BINDING PROTEIN ZC3H10 COUPLES MITOCHONDRIAL FUNCTION AND IRON METABOLISM". Doctoral thesis, Università degli Studi di Milano, 2017. http://hdl.handle.net/2434/481986.
Pełny tekst źródłaYatherajam, Gayatri. "Regulation of transcription by factors interacting with the TATA binding protein". Access citation, abstract and download form; downloadable file 7.32 Mb, 2004. http://wwwlib.umi.com/dissertations/fullcit/3131704.
Pełny tekst źródłaWang, Weizhong. "Nuclear galectins and their role in pre-mRNA splicing". Diss., Connect to online resource - MSU authorized users, 2006.
Znajdź pełny tekst źródłaTitle from PDF t.p. (viewed on Nov. 20, 2008) Includes bibliographical references. Also issued in print.
Whitman, Samantha. "Fragile X Related Protein-1 (FXR1) Regulates RNA Metabolism in Striated Muscle". Diss., The University of Arizona, 2011. http://hdl.handle.net/10150/195153.
Pełny tekst źródłaJames, Marion Clare. "The role of the La antigen and associated RNAs in the regulation of protein synthesis". Thesis, St George's, University of London, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243864.
Pełny tekst źródłaTollervey, James Robert. "Understanding misregulation of alternative splicing in the human TDP-43 proteinopathies". Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609056.
Pełny tekst źródłaSun, Xueguang. "Characterization of E. coli HFQ structure and its RNA binding properties". Available online, Georgia Institute of Technology, 2006, 2006. http://etd.gatech.edu/theses/available/etd-12052005-145342/.
Pełny tekst źródłaWartell Roger, Committee Chair ; Chernoff Yury, Committee Member ; Harvey Stephen, Committee Member ; Spiro Stephen, Committee Member ; Williams Loren, Committee Member.
Behrmann, Jason. "Determining the role of the RNA-binding protein, RasGAP- SH3 domain-binding protein, in the mammalian cellular response to ultraviolet radiation". Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=18459.
Pełny tekst źródła"RasGAP—SH3-domain Binding Protein (G3BP)" est un endoribonucléase qui associe la voie de signalisation de Ras et la stabilité d'ARN messager. On ne connaît pas une fonction bien défini pour cette protéine, même si c'est impliquée dans plusieurs rôles cellulaire. Le but de cette dissertation est d'appuyer l'implication du G3BP1 aux réponses cellulaire mammalien au stress environmental, particulièrement à la radiation ultraviolet. On observe le G3BP1 transverse du cytoplasm au noyau au traitement des cellules HeLa avec des doses UV apoptotique. La chose fascinante est quand on introduit s'accumulation du noyau en l'absence du stress est suffisant de provoquer les charactéristiques apoptotique. Les observations au premier degré suggèrent que les signalisations d'origine de membrane plasmique et l'activation resultant du JNK, p38 MAPK, et CASPases peuvent jouer un rôle en ce processus. Ainsi, on a élaboré le rôle du G3BP1 en réponse cellulaire au stress et suggère une nouvelle fonction pour la protéine : la promotion de l'apoptose.
Bertossi, Arianna. "Role of the RNA-binding protein Roquin in immune homeostasis and autoimmunity". Diss., lmu, 2011. http://nbn-resolving.de/urn:nbn:de:bvb:19-137761.
Pełny tekst źródłaBlais-Crépeau, Marie-Laure. "The Double-stranded RNA-binding Protein Staufen1 Negatively Regulates Skeletal Muscle Differentiation". Thesis, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/19766.
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