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Rozprawy doktorskie na temat „RETROVIRAL PROTEASE”

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Data publikacji: 6 września 2023

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Sprawdź 33 najlepszych rozpraw doktorskich naukowych na temat „RETROVIRAL PROTEASE”.

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1

Peng, Kah Whye. "Protease-activatable targeted retroviral vectors." Thesis, University of Cambridge, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.624668.

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2

Garner, Joanne Clare. "Site directed mutagenesis, autoprocessing and inhibitor studies on the retroviral protease of the human immunodeficiency virus type-1." Thesis, University of Southampton, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.302318.

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3

Muller, Natalie Guida. "Identificação de epitopos da protease de HIV-1 alvos de respostas de células T CD4+ em pacientes infectados pelo HIV-1." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/5/5146/tde-05032010-170301/.

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Introdução: Uma proporção significante de pacientes infectados por HIV-1 (pacientes HIV-1+) tratados com inibidores de protease (IPs) desenvolve mutações de resistência. Estudos recentes têm mostrado que células T CD8+ de pacientes HIV- 1+ reconhecem epitopos de Pol incluindo mutações selecionadas por drogas. Nenhum epitopo CD4+ da protease foi descrito na base de dados de Los Alamos. Objetivo: Considerando que a protease de HIV-1 é alvo de terapia antiretroviral e que essa pressão pode selecionar mutações, nós investigamos se mutações selecionadas por IPs afetariam o reconhecimento de epitopo
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4

Junaid, Muhammad. "Studies of Retroviral Reverse Transcriptase and Flaviviral Protease Enzymes as Antiviral Drug Targets : Applications in Antiviral Drug Discovery & Therapy." Doctoral thesis, Uppsala universitet, Institutionen för farmaceutisk biovetenskap, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-173504.

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Viruses are a major threat to humans due to their unique adaptability, evolvability and  capability to control their hosts as parasites and genetic elements. HIV/AIDS is the third largest cause of death by infectious diseases in the world, and drug resistance due to the viral mutations is still the leading cause of treatment failure. The flaviviruses, such as Dengue virus (DEN) and Japanese encephalitis virus (JEV), represent other major cause of morbidity and mortality, and the areas where these viruses are endemic are spreading rapidly. No curative therapy for any flavivirus could be made av
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5

Hinks, John Andrew. "Studies of retroviral proteases." Thesis, University College London (University of London), 2005. http://discovery.ucl.ac.uk/1445580/.

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This work is primarily concerned with the expression, purification, and characterisation of aspartic proteases from three retroviruses of the lentivirus subgroup, specifically the Human Immunodeficiency Viruses types 1 and 2, and the Simian Immunodeficiency Virus isolated from the African Green Monkey (HIV-1 PR, HIV-2 PR, SIVagm PR respectively). These viruses cause immunodeficiency syndromes within their respective hosts, and understanding their molecular biology would facilitate development of Acquired Immunodeficiency Syndrome (AIDS) treatments in man. The proteases are essential to viral m
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6

Leblanc, Pascal. "Retrovirus d'invertebres : zam un nouveau candidat chez drosophila melanogaster." Clermont-Ferrand 1, 1998. http://www.theses.fr/1998CLF1MM12.

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7

GESSNER, JEAN-YVES. "La proteine de la nucleocapside du retrovirus vih-1." Strasbourg 1, 1992. http://www.theses.fr/1992STR15031.

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8

Schucht, Roland. "Entwicklung von flexiblen Zelllinien für die Produktion rekombinanter Proteine und Retroviren." kostenfrei, 2006. http://www.digibib.tu-bs.de/?docid=00014003.

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9

Morphet, Marilynn Norma. "Method for identification of effective first-line treatment for HAART naïve HIV/AIDS patients." Thesis, Queensland University of Technology, 2002.

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10

Ménard, Armelle. "Purification, activité et inhibition de la protéase du rétrovirus BLV : un modèle d'étude pour celle du HTLV-1." Bordeaux 2, 1994. http://www.theses.fr/1993BOR28278.

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11

GUYONNET, FRANCK. "La proteine p27 de groupe des retrovirus aviaires : production d'anticorps monoclonaux et etude de l'antigenicite." Tours, 1993. http://www.theses.fr/1993TOUR4007.

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La proteine p27 de groupe des retrovirus aviaires a ete purifiee a partir du virus exogene amv(mav)b, par electrophorese preparative et electroelution. Les caracterisations biochimiques et immunologiques de cette proteine ont confirme le polymorphisme structural que presente ce constituant majeur de la capside virale. Une collection de 320 anticorps monoclonaux diriges contre cette proteine a ete isolee et l'etude de la distinction entre les virus exogenes et endogenes de leucoses aviaires a l'aide de ces anticorps a ete effectuee. L'un d'entre eux reagit specifiquement avec les virus exogenes
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12

Cartellieri, Marc. "Untersuchungen zum Gag- und Pol-Protein des Prototypischen Foamyvirus (PFV)." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2006. http://nbn-resolving.de/urn:nbn:de:swb:14-1149777659789-93621.

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Innerhalb der Retroviren unterscheiden sich die Foamyviren (FV) bezüglich ihrer Proteinexpression, der Partikelmorphogenese und ihres Reproduktionszyklus deutlich von den Orthoretroviren. Im Rahmen dieser Arbeit wurden zwei exklusive Merkmale der Foamyviren, die ungewöhnliche Struktur des Gag-Proteins und die Gag unabhängige Pol-Expression, in ihrer Auswirkung auf Morphogenese und Zusammensetzung foamyviraler Partikel untersucht. Für die Morphogenese infektiöser Partikel sind sehr unterschiedliche Mengen der Genprodukte eines Retrovirus nötig. Im Gegensatz zu den Orthoretroviren wird bei Foamy
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13

Teysset, Laure. "La proteine d'enveloppe du retrovirus gypsy : etude de son role et de sa fonction chez drosophila melanogaster." Paris 7, 1998. http://www.theses.fr/1998PA077155.

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L'element gypsy est un retrovirus endogene de drosophile. Sa mobilite est controlee par le gene flamenco au niveau de la transcription de gypsy. Ce gene a un effet maternel, car gypsy ne transpose que chez les descendants de femelles homozygotes pour l'allele permissif de flamenco. Afin d'etablir un protocole experimental permettant de suivre gypsy au cours de son cycle de replication, des lignees transgeniques de drosophile, contenant un element marque dans le gene env, ont ete obtenues. Leurs etudes indiquent que, meme si le clone de l'element gypsy utilise n'est pas autonome pour sa transpo
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14

Trentin, Bernadette. "Transcriptase inverse du HTLV-I : expression, structure et rôle dans l'infectiosité/." Bordeaux 2, 1999. http://www.theses.fr/1999BOR28640.

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15

Cartellieri, Marc. "Untersuchungen zum Gag- und Pol-Protein des Prototypischen Foamyvirus (PFV)." Doctoral thesis, Technische Universität Dresden, 2005. https://tud.qucosa.de/id/qucosa%3A24712.

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Innerhalb der Retroviren unterscheiden sich die Foamyviren (FV) bezüglich ihrer Proteinexpression, der Partikelmorphogenese und ihres Reproduktionszyklus deutlich von den Orthoretroviren. Im Rahmen dieser Arbeit wurden zwei exklusive Merkmale der Foamyviren, die ungewöhnliche Struktur des Gag-Proteins und die Gag unabhängige Pol-Expression, in ihrer Auswirkung auf Morphogenese und Zusammensetzung foamyviraler Partikel untersucht. Für die Morphogenese infektiöser Partikel sind sehr unterschiedliche Mengen der Genprodukte eines Retrovirus nötig. Im Gegensatz zu den Orthoretroviren wird bei Foamy
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16

Cunha, Joel da. "Estudo da atividade e polimorfismos da Paraoxonase-1 em indivíduos infectados pelo vírus da imunodeficiência humana tipo-1 (HIV-1) tratados com inibidores de protease." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/5/5146/tde-10052013-095130/.

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A enzima Paraoxonase-1 (PON1) possui atividades paraoxonase, arilestearase e lactonase, entre outras. É a mais estuda da família das PONs que é composta pela PON1, PON2 e PON3. Sugere-se, que todas atuam inibindo o processo de peroxidação lipídica de moléculas como a lipoproteína de baixa densidade (LDL) e alta densidade (HDL), caracterizando assim um possível papel anti-aterogênico. O gene da PON1 apresenta dois sítios polimórficos, com a troca de uma Gln192Arg (Q/R) e Met55Leu, que estão associados com diferenças na atividade e concentrações séricas da enzima. Por sua vez, indivíduos soropos
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17

Kontijevskis, Aleksejs. "Modeling the Interaction Space of Biological Macromolecules: A Proteochemometric Approach : Applications for Drug Discovery and Development." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8916.

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18

Dörrschuck, Eva Amarant [Verfasser], and Manfred J. [Akademischer Betreuer] Schmitt. "Molekularbiologische Untersuchungen zur Interaktion der antiretroviral wirkenden porzinen und humanen A3-Proteine mit porzinen endogenen Retroviren (PERV) und Charakterisierung des porzinen A3-Genlokus / Eva Amarant Dörrschuck. Betreuer: Manfred J. Schmitt." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2011. http://d-nb.info/1051095344/34.

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19

Voisset, Cécile. "Étude de la nouvelle famille de rétrovirus endogènes humains HERV-W dans un contexte normal et dans un contexte pathologique (sclérose en plaques)." Lyon 1, 1999. http://www.theses.fr/1999LYO1T132.

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20

WECKER, KARINE. "Etudes structurales par resonance magnetique homonucleaire et heteronucleaire, et par modelisation moleculaire de la proteine de regulation vpr du retrovirus vih-1, et de deux de ses fragments, vpr(1-51) et vpr(52-96)." Paris 6, 2000. http://www.theses.fr/2000PA066476.

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La proteine de regulation vpr du retrovirus vih-1 est une petite proteine basique de 96 acides amines, 14 kda, hautement conservee chez vih-1, vih-2 et siv, et presente dans le virus en quantite importante, comparable a celles de gag. Vpr est impliquee dans un grand nombre d'etape de l'infection virale via des interactions avec des partenaires cellulaires ou viraux. Ainsi elle influence la transcription inverse, regule la replication virale, intervient dans la translocation nucleaire du complexe de preintegration, forme des canaux ioniques dans les membranes lipidiques, stimule la transcriptio
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21

Legrand, Alain. "Liposomes cibles et vecteurs retroviraux pour le transfert et l'expression du gene de la preproinsuline i de rat dans des cellules eucaryotes." Orléans, 1987. http://www.theses.fr/1987ORLE2011.

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Encapsulation d'adn dans des liposomes contenant du lactosylceramide dont le sucre terminal est reconnu specifiquement par des recepteurs presents sur la membrane plasmique des cellules visees, c. A. D. , les hepatocytes et les cellules endotheliales du foie et egalement les lymphocytes de la rate. Injection par voie intraveineuse des liposomes. Role de l'endocytose, dans leur internalisation. Modele genetique constitue du gene de la preproinsuline i de rat insere dans des vecteurs retroviraux permettant l'expression du gene dans des celules non insulogenes
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22

Gillcrist, Marion. "HIV, cardiovascular disease, anti-retroviral resistance: the issue with protease inhibitors and a need for alternatives." Thesis, 2020. https://hdl.handle.net/2144/41243.

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Today, it is estimated that 35 million people are living with human immunodeficiency virus (HIV). Since its initial discovery in 1981, researchers and medical providers have worked endless hours to understand the pathology, transmission, and medical management of HIV. In the early days of HIV, life expectancy after diagnosis was 10 years. However, after the development of zidovudine (AZT) in 1987, life expectancy of HIV patients began to slowly increase, albeit still lower than that of the general population. The development of AZT opened the door for more antiretroviral drugs and more drug cl
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23

Biswas, Iman. "Structural and functional studies on DNA damage inducible protein 1 (Ddi1) from protozoa." Thesis, 2020. https://etd.iisc.ac.in/handle/2005/4838.

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Structural and functional investigations on DNA-damage inducible protein1 (Ddi1) from Entamoeba histolytica, Trypanosoma cruzi and Toxoplasma gondii have been carried out. Ddi1 belongs to the ubiquitin receptor family of proteins. One of its domains is similar to the retroviral aspartic proteinases. It has been shown that this domain is the target of HIV-protease inhibitors that were being used in the treatment of AIDS and it was observed that these drugs reduced the infection caused by many parasitic protozoa such as Trypanosoma and Leishmania species that are responsible for prevalent opport
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24

Ziregbe, Elohor. "A comparison of the effectiveness of protease inhibitor-based highly active anti-retroviral treatment regiments in Trinidad and Tobago." Diss., 2013. http://hdl.handle.net/10500/14199.

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Few studies have assessed the optimum second line highly active anti-retroviral therapy (HAART) regimen in patients who had failed on the first-line HAART in resource-limited settings. This study aimed to compare the Protease inhibitor (PI)-based second line HAART regimens used in one clinic in Trinidad by comparing immunological, virological and clinical outcomes of patients on the different second line HAART regimens. The records of 35 treatment-experienced patients, over 21years of age and on PI-based regimens for at least six months, were analysed using SPSS version 20. The regimen
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25

Finger, Carsten [Verfasser]. "Entwicklung retroviraler scFv-display-Bibliotheken und Expression therapeutischer Proteine durch replikationskompetente retrovirale Vektoren / von Carsten Finger." 2006. http://d-nb.info/980649730/34.

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26

Kumar, Sushant. "Structural Studies on DNA Damage Inducible Protein 1 (Ddi1) of Leishmania and the Rotavirus Nonstructural Protein NSP4." Thesis, 2016. http://etd.iisc.ac.in/handle/2005/3018.

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Structuraj investigations on the Ddi1 (DNA-damage inducible protein 1) of Leishmania major and on the rotavirus nonstructural protein NSP4 were carried out. Ddi1 belongs to the ubiquitin receptor family of proteins. One of its domains is similar to the retroviral aspartic proteinases. It has been shown that this domain is the target of HIV-protease inhibitors that were being used in the treatment of AIDS and it was observed that these drugs effectively controlled opportunistic diseases caused by many parasitic protozoa such as Leishmania and Plasmodium species. The retroviral protease-like dom
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27

Kumar, Sushant. "Structural Studies on DNA Damage Inducible Protein 1 (Ddi1) of Leishmania and the Rotavirus Nonstructural Protein NSP4." Thesis, 2016. http://hdl.handle.net/2005/3018.

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Structuraj investigations on the Ddi1 (DNA-damage inducible protein 1) of Leishmania major and on the rotavirus nonstructural protein NSP4 were carried out. Ddi1 belongs to the ubiquitin receptor family of proteins. One of its domains is similar to the retroviral aspartic proteinases. It has been shown that this domain is the target of HIV-protease inhibitors that were being used in the treatment of AIDS and it was observed that these drugs effectively controlled opportunistic diseases caused by many parasitic protozoa such as Leishmania and Plasmodium species. The retroviral protease-like dom
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28

Cruz, Rui Gonçalo Batista Mamede da. "New retroviral-like membrane-associated aspartic proteases from rickettsiae: biochemical characterization and specificity profiling." Doctoral thesis, 2015. http://hdl.handle.net/10316/26477.

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Tese de doutoramento em Bioquímica, na especialidade de Tecnologia Bioquímica, apresentada ao Departamento de Ciências da Vida da Faculdade de Ciências e Tecnologia da Universidade de Coimbra<br>Os membros do género Rickettsia são bactérias intracelulares obrigatórias do tipo gram-negativas, cuja transmissão a mamíferos pode ocorrer através de vetores artrópodes como carraças, pulgas ou piolhos. Entre as várias espécies identificadas, muitas são patogénicas para o Homem causando doenças infeciosas agudas das quais se destacam o tifo epidémico (Rickettsia prowazekii), a febre maculosa das monta
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29

Shityakov, Sergey. "Molecular modelling and simulation of retroviral proteins and nanobiocomposites." Doctoral thesis, 2011. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-56960.

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Molecular modelling and simulation are powerful methods in providing important in-formation on different biological systems to elucidate their structural and functional proper-ties, which cannot be determined in experiment. These methods are applied to analyse versa-tile biological systems: lipid membrane bilayers stabilized by an intercalated single wall carbon nanotube and retroviral proteins such as HIV protease and integrase. HIV-1 integrase has nuclear localization signals (NLS) which play a crucial role in nuclear import of viral preintegration complex (PIC). However, the detailed mechan
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30

Schucht, Roland [Verfasser]. "Entwicklung von flexiblen Zelllinien für die Produktion rekombinanter Proteine und Retroviren / von Roland Schucht." 2006. http://d-nb.info/982016700/34.

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31

Rold, Christopher James. "The role of the cellular proteasome and ubiquitin in post-entry restriction of retroviruses by TRIM5[alpha]." Diss., 2009. http://etd.library.vanderbilt.edu/available/etd-03302009-150129/.

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32

Santos, Andreia Sofia M. 1980. "Efeitos metabólicos associados à terapêutica anti-retroviral na infecção por VIH-1 : a experiência de utilização do atazanavir na prática clínica." Master's thesis, 2009. http://hdl.handle.net/10451/1048.

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Tese de mestrado, Doenças Infecciosas Emergentes, Faculdade de Medicina, Universidade de Lisboa, 2009<br>The lipid profile of individuals infected with HIV-1 is characterized with high levels of total cholesterol, LDL cholesterol and triglycerides e low levels of HDL cholesterol. The regimens based in atazanavir (ATV) revealed improved metabolic and lipid profile in comparison with other protease inhibitors, with identical viral suppression. The objectives of this study were to analyse the efficacy and safety of boosted ATV as part of combination antiretroviral therapy in HIV-1 infected patien
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33

Brand, Isabel [Verfasser]. "Charakterisierung der Interaktion zwischen dem tumorassoziierten Protein Np9 des humanen endogenen Retrovirus HERV-K (HML-2) und der humanen Serin-Protease (HumHtrA2) / eingereicht von Isabel Brand." 2006. http://d-nb.info/979353041/34.

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