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Tan, Sue Zanne. "Dynamic regulation of pathways by down-regulating competing enzymes". Thesis, Massachusetts Institute of Technology, 2017. http://hdl.handle.net/1721.1/111402.
Pełny tekst źródłaCataloged from PDF version of thesis.
Includes bibliographical references (pages 106-116).
Microorganisms are promising hosts for the production of valuable chemicals, such as polymer and pharmaceutical precursors, fuel alternatives, flavors and fragrances. Achieving high yields of a product is often restricted by the interconnectivity of pathways in cells and finite nature of cellular resources. To overcome these limitations, dynamic pathway regulation has emerged as a strategy to balance flux between growth and production, such that titers and yields are maximized. Here, we demonstrate that dynamic pathway regulation by down-regulating competing enzymes can successfully improve yields of products. In Saccharomyces cerevisiae, we constructed a hexokinase valve where Hxk2 and GIk1 were deleted and the only remaining Hxk1 was placed under control of the tetracycline transactivating system (tTA) that enables repression of Hxk1 up to 10-fold in activity upon addition of doxycycline. Downregulation of this competing Hxk1 enzyme resulted in a 50-fold increase in gluconic acid and a 3-fold improvement in isobutanol yields from glucose. Extending this concept to other microorganisms, engineering downregulation of competing enzymes is dependent upon the ability to deplete a protein of interest in an inducible manner in the production host. In Pseudomonas spp., tools for specific protein depletion remain limited. Current methods involve promoter replacements and addition of degradation tags that require editing the genome, a process that can be laborious in Pseudomonas. Here, we developed a CRISPRi gene repression system by engineering the Streptococcus pasteurianus dCas9 and sgRNA. We demonstrate a robust and titratable gene depletion system, with up to 100-fold repression in [beta]-galactosidase activity in P. aeruginosa. We performed the first in vivo characterization of PAM site preferences of S. pasteurianus dCas9, revealing that targeting both NNGTGA and NNGCGA within the promoter can provide robust repression. Finally, the developed CRISPRi gene depletion system enabled the downregulation of competing muconate cycloisomerase in P. putida, leading to accumulation of muconic acid. In summary, we show that dynamic regulation of pathways by downregulating competing enzymes is an effective method to improve titers and yields of products. Controlling enzyme abundance at the transcriptional level proved successful with the existing tTA system in S. cerevisiae and with our developed CRISPRi system in Pseudomonas.
by Sue Zanne Tan.
Ph. D.
Matthews, Duncan Neville. "Characterising EC regulation : emulation, innovation, re-regulation". Thesis, London School of Economics and Political Science (University of London), 2008. http://etheses.lse.ac.uk/2577/.
Pełny tekst źródłaBoyce, Toussant. "Dynamic financial regulation : automaticity and auto-regulation". Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648541.
Pełny tekst źródłaBonleu, Antoine. "Housing market regulation and labor market regulation". Thesis, Aix-Marseille, 2016. http://www.theses.fr/2016AIXM2009/document.
Pełny tekst źródłaThe first contribution studies the complementarities between the strength of social networks and the stringency of procedural formalism. While procedural formalism increases the cost of legal dispute resolution between landlords and tenants, social networks allow conflicts to be solved without recourse to justice. Procedural formalism is thus a way to provide a market advantage to local individuals embedded in dense local social networks at the expense of nonlocal agents without access to such networks.The second contribution deals with the importance of the sun on the demand for regulation in the rental market. Southern European countries with good climate amenities are attractive by their mildness of life. This potential immigration increases the pressure on the rental market. To reduce it, individuals in Southern Europe develop complementarities between social capital and local regulations. This strategy explains a Mediterranean equilibrium characterized by high levels of local social capital and procedural formalism. Conversely, the lack of attractiveness of countries with low climate amenities leads to an Anglo-Saxon and Scandinavian equilibrium with opposite features.The third contribution explains the support for labor market regulation by the presence of regulations on the rental market. When the rental market is very regulated, landlords screen applicants with regard to their ability to pay the rent. Protecting regular jobs offers a second-best technology to sort workers, thereby increasing the rental market size. We provide a model where non-employed workers demand protected jobs despite unemployment and the share of short-term jobs increase
Hyder, Nishat. "Developing facilitative governance frameworks for emerging biotechnologies : exploring new approaches to cross-border regulation". Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/developing-facilitative-governance-frameworks-for-emerging-biotechnologies-exploring-new-approaches-to-crossborder-regulation(525a9a76-d3bc-43a8-adb4-1cd8c91d8583).html.
Pełny tekst źródłaTong, González Francisco. "Administrative Simplification and "Positive Regulation" in the Environmental and Mining Regulations". Derecho & Sociedad, 2015. http://repositorio.pucp.edu.pe/index/handle/123456789/119160.
Pełny tekst źródłaEn el presente artículo el autor reflexiona acerca de los objetivos y principios trazados en la década del noventa, en lo que respecta específicamente a la simplificación administrativa comparándolos con los objetivos actuales de dinamización de la economía y reducción de trámites innecesarios; principalmente, los referidos a procedimientos mineros y ambientales. Finalmente, el autor plantea la necesidad de un cambio estructural en la regulación ambiental y minera bajo la forma de lo que denomina una «regulación positiva».
Ross, John D. "Regulating Hypermedia: Self-regulation learning strategies in a hypermedia environment". Diss., Virginia Tech, 1999. http://hdl.handle.net/10919/26921.
Pełny tekst źródłaPh. D.
Averis, Roslyn Ann. "Regulation revisited : Australia's new economy and regulation theory /". Title page, abstract and table of contents only, 2001. http://web4.library.adelaide.edu.au/theses/09AR/09ara952.pdf.
Pełny tekst źródła李詠欣 i Wing-yan Lee. "Regulation of genes involved in cellular osmotic regulation". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1999. http://hub.hku.hk/bib/B31223011.
Pełny tekst źródłaLee, Wing-yan. "Regulation of genes involved in cellular osmotic regulation /". Hong Kong : University of Hong Kong, 1999. http://sunzi.lib.hku.hk/hkuto/record.jsp?B21301165.
Pełny tekst źródłaMarrs, Kevin L. "The cystic fibrosis transmembrane conductance regulator regulation by HSP-90 /". View the abstract Download the full-text PDF version, 2007. http://etd.utmem.edu/ABSTRACTS/2007-031-Marrs-index.html.
Pełny tekst źródłaTitle from title page screen (viewed on July, 18, 2008). Research advisor: Anjaparavanda Naren, Ph.D. Document formatted into pages (xv, 72 p. : ill.). Vita. Abstract. Includes bibliographical references (p. 66-72).
Madera, Laurence. "Mechanisms of immune response regulation by innate defense regulator peptides". Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/43066.
Pełny tekst źródłaTsao, Hui-Lan. "Telecommunication regulation". Thesis, University of Canterbury. Department of Economics, 2002. http://hdl.handle.net/10092/4662.
Pełny tekst źródłaThomas, David John. "Transcription regulation : models for combinatorial regulation and functional specificity". Thesis, University of Sussex, 2014. http://sro.sussex.ac.uk/id/eprint/48754/.
Pełny tekst źródłaChu, May. "The internationalisation of regulation : food safety regulation in China". Thesis, London School of Economics and Political Science (University of London), 2014. http://etheses.lse.ac.uk/961/.
Pełny tekst źródłaL'Huillier, Dominic. "Economic regulation of Queensland ports : market power and price regulation /". St. Lucia, Qld, 2004. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe18085.pdf.
Pełny tekst źródłaRados-Blanusa, Tijana. "Climatic and physiological regulation regulation of premature cherry fruit abscission". Thesis, Lancaster University, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.420175.
Pełny tekst źródłaEvans, Daniel R. "SELF-REGULATION IN OLDER ADULTS: THE PRIORITIZATION OF EMOTION REGULATION". UKnowledge, 2014. http://uknowledge.uky.edu/psychology_etds/43.
Pełny tekst źródłaAnnosi, Maria Carmela. "Regulation and Self-Regulation of Team Learning and Innovation Activities". Doctoral thesis, Stockholm, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-193568.
Pełny tekst źródłaQC 20161005
Sinclaire-Harding, Lysandra. "Profiling emotion regulation : exploring patterns of regulation in classroom behaviour". Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/271634.
Pełny tekst źródłaSzellas, Tanjef. "Regulation des CFTR". [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=964740117.
Pełny tekst źródłaAviram, Amitai. "Regulation by networks". Diss., John M. Olin Program in Law and Economics working paper series Social Science Research Network Electronic Paper Collection, 2003. http://ssrn.com/abstract%5Fid=387960.
Pełny tekst źródłaIonescu, Irina Gabriela. "Aircraft noise regulation". Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=82660.
Pełny tekst źródłaRAMOS, PAULO DANIEL SALLES. "DYNAMIC MONOPOLY REGULATION". PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2011. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=18422@1.
Pełny tekst źródłaPROGRAMA DE SUPORTE À PÓS-GRADUAÇÃO DE INSTS. DE ENSINO
O artigo estuda o problema de um regulador social que deseja induzir um monopolista natural a implementar um projeto de forma socialmente eficiente. O projeto tem longa duração e os custos do projeto variam de período a período de acordo com um processo estocástico. Adicionalmente, estuda-se a decisão de investimento do monopolista em tecnologia para se reduzir os custos deste projeto e como esta decisão está ligada ao contrato de produção oferecido pelo regulador. Mostra-se a forma que o contrato ótimo de regulação assume sob estas condições e como as distorções envolvidas no contrato são tão maiores quanto maiores forem as informações que a firma possui acerca de seus custos futuros. Mostra-se também que as distorções são tão maiores quanto maior for o investimento da firma em tecnologia e que por sua vez esse investimento caminha oposto aos custos sociais líquidos da tributação.
The paper studies the problem of a social regulator that wants to induce a natural monopolist to implement a project in a socially efficient way. The project has a long duration and project costs vary from period to period according to a stochastic process. Additionally, we study the investment decision of the monopolist in technology to reduce the cost of this project and how this decision is linked to the production contract offered by the regulator. We show the optimal contract that arises under these conditions and how the distortions involved in the contract are greater the higher the information that the firm has about its future costs. We also show that the distortions are greater the higher the firm’s investment in technology and in turn that investment goes to the opposite net social cost of taxation.
Hirte, Georg, i Hyok-Joo Rhee. "Regulation versus Taxation". Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-210925.
Pełny tekst źródłaZhang, Fan. "Regulation of G1 /". Helsinki : University of Helsinki, 2003. http://ethesis.helsinki.fi/julkaisut/laa/haart/vk/zhang/.
Pełny tekst źródłaToh, Yew Kwang. "Docking-dependent regulation of checkpoint kinase chk1 by the growth regulator p21WAF1". Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/4215.
Pełny tekst źródłaSangha, Dalvinder Singh. "The role of the regulator, auditor and banker : the limits of regulation". Thesis, University of Wolverhampton, 2002. http://hdl.handle.net/2436/96285.
Pełny tekst źródłaCrutzen, Helene Sabine Giovanna. "Cis-regulation of MyoD : a systems analysis of a fate master regulator". Thesis, University College London (University of London), 2009. http://discovery.ucl.ac.uk/17977/.
Pełny tekst źródłaSenesac, Erin. "Cognitive depletion in emotion regulation: age differences depend on regulation strategy". Thesis, Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/34837.
Pełny tekst źródłaDodd, Jessica Amen Alexandra Fineman Stephanie. "Mechanisms of self-regulation associations between cognitive control and emotion regulation /". Diss., Connect to the thesis, 2008. http://hdl.handle.net/10066/1427.
Pełny tekst źródłaGuimbellot, Jennifer S. "Role of hypoxia in epithelial gene regulation". Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2007. https://www.mhsl.uab.edu/dt/2009r/guimbellot.pdf.
Pełny tekst źródłaAnsari, Saira. "Calcium control of smooth muscle myofilament activity : an integrated dual regulations [i.e regulation system]". Thesis, Imperial College London, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.405559.
Pełny tekst źródłaQuirin, Markus. "Self-System and Regulation of Negative Affect [Selbstsystem und Regulation negativen Affekts]". Doctoral thesis, [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=979018439.
Pełny tekst źródłaDoelker, Andreas. "Self-regulation and co-regulation : prospects and boundaries in an online environment". Thesis, University of British Columbia, 2010. http://hdl.handle.net/2429/27918.
Pełny tekst źródłaSmith, G. "Corporate governance : In search of balance between state regulation and self regulation". Thesis, Queen's University Belfast, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.517519.
Pełny tekst źródłaWong, Lai-ching Elyssa, i 黃麗菁. "Government re-regulation and de-Regulation of the Hong Kong bus industry". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1995. http://hub.hku.hk/bib/B31954510.
Pełny tekst źródłaWong, Lai-ching Elyssa. "Government re-regulation and de-Regulation of the Hong Kong bus industry". [Hong Kong : University of Hong Kong], 1995. http://sunzi.lib.hku.hk/hkuto/record.jsp?B15967347.
Pełny tekst źródłaKulacz, Wojciech. "Regulation of Inverted Formin-1 (INF1) by Microtubule-Affinity Regulating Kinase 2 (MARK2)". Thèse, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/22801.
Pełny tekst źródłaRowntree, Rebecca Kate. "Regulation of expression of the human cystic fibrosis transmembrane conductance regulator (CFTR) gene". Thesis, University of Oxford, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.393265.
Pełny tekst źródłaLovewell, Thomas. "A study into the regulation and function of the Autoimmune Regulator (AIRE) Gene". Thesis, University of Sheffield, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.500224.
Pełny tekst źródłaEngland, Alice. "The regulation of the cystic fibrosis transmembrane conductance regulator in human respiratory epithelia". Thesis, University of Sheffield, 2013. http://etheses.whiterose.ac.uk/3788/.
Pełny tekst źródłaAzzini, Matilde. "Sustainable Financial Disclosure Regulation". Master's thesis, Alma Mater Studiorum - Università di Bologna, 2021.
Znajdź pełny tekst źródłaMartínez, Corral Rosa 1991. "Modelling spatiotemporal cell regulation". Doctoral thesis, Universitat Pompeu Fabra, 2018. http://hdl.handle.net/10803/664968.
Pełny tekst źródłaEn aquesta Tesi hem estudiat com la dinàmica i l’espai modulen el comportament cel·lular, mitjançant models matemàtics de diversos exemples biològics. A nivell de cèl·lules individuals, mostrem que senyals polsàtils poden ser interpretats per les corresponents dianes intracel·lulars gràcies a circuits amb arquitectures i escales temporals de resposta adequades. Pel que fa a la generació de polsos, mostrem que polsos estocàstics poden produir-se a partir de l’amplificació d’una pertorbació mitjançant interaccions de retroalimentació negativa. Més enllà de cèl·lules individuals, proposem que oscil·lacions en comunitats bacterianes emergeixen de la limitació de glutamat al centre del biofilm, transmesa per senyalització per potassi a través de la comunitat, i que poden ser conceptualitzades en termes d’una bifurcació de Hopf subcrítica. A més a més, parelles de biofilms sincronitzen la seva dinàmica, donant lloc a un fenomen de compartició de recursos en el temps. Finalment, proposem que l’àrea de contacte entre cèl·lules modifica el destí cel·lular en el context de l’homeòstasi intestinal de Drosophila.
Kollmeyer, Jessica Elaine. "Regulation of Galactosylceramide Biosynthesis". Thesis, Georgia Institute of Technology, 2006. http://hdl.handle.net/1853/11630.
Pełny tekst źródłaMellberg, Sofie. "Molecular Regulation of Angiogenesis". Doctoral thesis, Uppsala universitet, Institutionen för genetik och patologi, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9418.
Pełny tekst źródłaWardęga, Piotr. "Regulation of PDGFRβ signaling ". Doctoral thesis, Uppsala universitet, Ludwiginstitutet för cancerforskning, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-123045.
Pełny tekst źródłaTurner, Martin John Charles. "Regulation of cytokine production". Thesis, Imperial College London, 1990. http://hdl.handle.net/10044/1/46588.
Pełny tekst źródłaHillier, Stephen Gilbert. "Regulation of ovarian function". Thesis, University of Edinburgh, 1992. http://hdl.handle.net/1842/26607.
Pełny tekst źródłaLivingstone, Karen. "Emotion regulation in psychosis". Thesis, University of Edinburgh, 2006. http://hdl.handle.net/1842/29225.
Pełny tekst źródła