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Rozprawy doktorskie na temat „Recombinant Salmonella vaccine”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 5 lutego 2022

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1

Hand, Nicholas. "Development of a Recombinant Attenuated Salmonella Cancer Vaccine." Thesis, The George Washington University, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10635177.

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<p>New treatments for neuroblastoma are desperately needed; high-risk neuroblastoma patients have a less than 50% five-year survival rate despite intensive treatment. The greatest impact on improving survival rates for cancer patients in recent years is the result of a number of immunotherapeutic approaches. A proportion of high-risk neuroblastoma patients undergo spontaneous regression, possibly mediated by the immune system, indicating the potential of immunotherapies targeting neuroblastoma-associated antigens. Recombinant attenuated Salmonella vaccines (RASV) are cost-effective and have s

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Breau, Cathy. "Development of an oral recombinant chancroid vaccine delivered by attenuated Salmonella typhimurium SL3261." Thesis, University of Ottawa (Canada), 2009. http://hdl.handle.net/10393/28079.

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Chancroid, a sexually transmitted genital ulcer disease caused by the Gram-negative bacterium Haemophilus ducreyi, facilitates the acquisition and transmission of H1V. An effective vaccine against chancroid has yet to be developed. We hypothesize that a Salmonella vector-based vaccine, expressing H. ducreyi antigens, could confer protective immunity in the rabbit model of H. ducreyi infection. The H. ducreyi outer membrane hemoglobin receptor HgbA has been shown to be a suitable vaccine candidate. HgbA was expressed from S. typhimurium SL3261 (pnirBhgbA) but not from the control strain, S. typ

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O’Meara, Kellie Marcella. "Evaluation of Recombinant Salmonella Expressing CD154 for Enhanced Immune Responses in Commercial Turkeys." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1246567532.

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Kremer, Courtney J. "Evaluation of Recombinant Salmonella Expressing the Flagellar Protein FliC for Enhanced Immune Responses in Commercial Turkeys." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1246568225.

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Silva, Maria Elizabeth. "Development of a Recombinant Attenuated Salmonella Vaccine System for Taenia Solium Cysticercosis in Pigs." Digital Archive @ GSU, 2010. http://digitalarchive.gsu.edu/biology_diss/81.

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Taenia solium is a cestode that has a two-hosts life cycle. The adult tapeworm causes an asymptomatic disease known as taeniasis whereas the larval stage causes a disease called cysticercosis. In humans, the most common localization for the larvae is the central nervous system where it produces the neurological disorder neurocysticerco-sis. Previous works by several research groups around the world have shown that T. so-lium is a potentially eradicable parasite. Control programs have included treatment of human and pig populations with antihelmintics in conjunction with health education and ar

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Łaniewski, Paweł, Chang-Ho Baek, Kenneth L. Roland, and Roy Curtiss. "Analysis of Spleen-Induced Fimbria Production in Recombinant Attenuated Salmonella enterica Serovar Typhimurium Vaccine Strains." AMER SOC MICROBIOLOGY, 2017. http://hdl.handle.net/10150/625743.

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Salmonella enterica serovar Typhimurium genome encodes 13 fimbrial operons. Most of the fimbriae encoded by these operons are not produced under laboratory conditions but are likely to be synthesized in vivo. We used an in vivo expression technology (IVET) strategy to identify four fimbrial operons, agf, saf, sti, and stc that are expressed in the spleen. When any three of these operons were deleted, the strain retained wild-type virulence. However, when all four operons were deleted, the resulting strain was completely attenuated, indicating that these four fimbriae play functionally redundan

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Holden, James Anthony, and jamesholden@netspace net au. "Vaccination Strategies for the Prevention of Swine Dysentery." RMIT University. Applied Sciences, 2006. http://adt.lib.rmit.edu.au/adt/public/adt-VIT20070112.122102.

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The SmpA outer membrane lipoprotein of B. hyodysenteriae has several characteristics that indicate the potential to protect against swine dysentery (SD). It localises to the outer membrane and antibodies directed against SmpA can prevent the growth of B. hyodysenteriae in vitro. There is some variation observed in the distribution and expression of the SmpA lipoprotein, suggesting that vaccination with SmpA may not provide protection against challenge with a heterologous B. hyodysenteriae strain. This study has characterised the variation at the smpA locus, and in the process has identified

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8

Sevil, Victoria. "Influence of oral boost immunizations with recombinant Salmonella vaccine strains on the antigen-specific CD8 T-cell induction." Diss., lmu, 2007. http://nbn-resolving.de/urn:nbn:de:bvb:19-72867.

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Franzin, Fernanda Maria 1981. "Construção e analise da imunogenicidade de uma linhagem atenuada de Salmonella enterica produtora do dominio M2 do antigeno MAEBL de Plasmodium yoelii." [s.n.], 2009. http://repositorio.unicamp.br/jspui/handle/REPOSIP/317036.

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Orientadores: Marcelo Brocchi, Fabio Trindade Maranhão Costa<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-14T03:58:59Z (GMT). No. of bitstreams: 1 Franzin_FernandaMaria_M.pdf: 1412458 bytes, checksum: 2fe89ebc9e03c37ffcc48000024a232d (MD5) Previous issue date: 2009<br>Resumo: A malária é uma doença tropical causada pelo parasita Plasmodium spp e é considerada um sério problema de saúde pública. São aproximadamente 500 milhões de casos anuais e mais de um milhão de mortes, especialmente na África e Ásia. No Brasil,

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Chin'ombe, Nyasha. "Recombinant Salmonella enterica serovar Typhimurium vaccine vector expressing green fluorescent protein as a model antigen or human immunodeficiency virus type 1 subtype C Gag." Doctoral thesis, University of Cape Town, 2007. http://hdl.handle.net/11427/2723.

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Gatsos, Xenia, and xgatsos@optusnet com au. "The development of live vectored vaccines targeting the alpha-toxin of Clostridium perfringens for the prevention of necrotic enteritis in poultry." RMIT University. Applied Sciences, 2007. http://adt.lib.rmit.edu.au/adt/public/adt-VIT20080212.142403.

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The Ñ-toxin of Clostridium perfringens is a toxin involved in numerous diseases of humans and agriculturally important animals. One of these diseases is necrotic enteritis (NE), a sporadic enteric disease which affects avian species world-wide. This study involved the inactivation of alpha-toxin (Ñ-toxin) for use as a potential vaccine candidate to combat NE in chickens, and other diseases caused by C. perfringens type A. During the course of this research a number of Ñ-toxin recombinant proteins were developed through molecular inactivation of the Ñ-toxin gene, plc. Proteins plc3

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Silva, Adilson José da. "Vacinas recombinantes contra erisipela suína: desenvolvimento integrado de bioprocesso, da biologia molecular ao biorreator." Universidade Federal de São Carlos, 2011. https://repositorio.ufscar.br/handle/ufscar/255.

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Made available in DSpace on 2016-06-02T19:02:40Z (GMT). No. of bitstreams: 1 3950.pdf: 2965296 bytes, checksum: 1e00d517bd464f272b8c1a2c9f67ca9c (MD5) Previous issue date: 2011-10-11<br>Valée S.A.<br>Swine erysipelas is among the diseases that causes great economic losses in swine cultures worldwide. The disease is caused by the bacterium Erysipelothrix rhusiopathiae, and the surface protein SpaA is one of its main antigens. Herein, we report studies concerning the development of recombinant vaccines against swine erysipelas based on the SpaA antigen. Protein production for a subunit vaccine

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13

Ashby, Deborah. "Feasibility of testing recombinant oral attenuated Salmonella vaccines in rabbits." Thesis, University of Ottawa (Canada), 2002. http://hdl.handle.net/10393/6248.

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An effective vaccine against chancroid could take the place of therapeutic control programs, offering long-lasting protection without the risk of widespread drug resistance. Orally administered recombinant attenuated Salmonella strains are used as vaccine vectors to deliver heterologous, pathogen-derived antigens to intestinal mucosal associated lymphoid tissue, and to provide vaccine adjuvancy. Chancroid vaccines are tested in a temperature-dependent rabbit model of experimental H. ducreyi infection. However, testing of recombinant attenuated Salmonella strains as vaccine vectors has never b

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14

Pike, Lewis James. "Salmonella vaccines : the impact of antigenic location on immune responses." Thesis, University of York, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313867.

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15

Zheng, Songyue, and 郑嵩岳. "Comparative immunological evaluation of recombinant Salmonella typhimurium strains expressing model antigens as live oral vaccines." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B49617734.

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Despite the development of various systems to generate live recombinant Salmonella Typhimurium vaccine strains, little work has been performed to systematically evaluate and compare their relative immunogenicity. Such information would provide invaluable guidance for the future rational design of live recombinant Salmonella oral vaccines. Here, a series of recombinant Salmonella Typhimurium strains were constructed to express either the enhanced green fluorescent protein (EGFP) or a fragment of the hemagglutinin (HA) protein from the H5N1 influenza virus, as model antigens. To investigate dif

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16

Azevedo, Fátima da Piedade de Melo. "Inserção de epitopo heterólogo em diferentes regiões de flagelina bacteriana: influência na função flagelar e imunogenicidade." Universidade de São Paulo, 1997. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-09112015-150421/.

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Uma das estratégias mais promissoras para a biotecnologia de vacinas é o desenvolvimento de linhagens precisamente atenuadas, e que possam ser usadas como carregadoras de antígenos heterólogos. Mutantes de <i}>Salmonella Typhimurium têm sido extensivamente utilizados com essa fmalidade. A flagelina, monômero constituinte do filamento flagelar, vem sendo empregada como carregadora de antígenos heterólogos, inseridos na região central, hipervariável (região IV). Inserções nessa região são freqüentemente funcionais, e levam à exposição do epitopo na superfície do filamento. O presente trabalho ex

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17

Camillo, Luciana. "Efeito da imunização com vacina do antígeno recombinante de superfície SpaA de Erysipelothrix rhusiopathiae : modelo murino." Universidade Federal de São Carlos, 2015. https://repositorio.ufscar.br/handle/ufscar/7741.

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Submitted by Luciana Sebin (lusebin@ufscar.br) on 2016-09-28T13:10:47Z No. of bitstreams: 1 DissLC.pdf: 1362892 bytes, checksum: c909112bd0ccd7d43250543e0d7d4a5e (MD5)<br>Approved for entry into archive by Marina Freitas (marinapf@ufscar.br) on 2016-10-10T14:52:29Z (GMT) No. of bitstreams: 1 DissLC.pdf: 1362892 bytes, checksum: c909112bd0ccd7d43250543e0d7d4a5e (MD5)<br>Approved for entry into archive by Marina Freitas (marinapf@ufscar.br) on 2016-10-10T14:52:36Z (GMT) No. of bitstreams: 1 DissLC.pdf: 1362892 bytes, checksum: c909112bd0ccd7d43250543e0d7d4a5e (MD5)<br>Made available in DSpac

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Monaris, Denize. "Avaliação do potencial adjuvante da flagelina FliCi de Salmonella enterica sorovar Thyphimurium no desenvolvimento de uma vacina contra leptospirose." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/87/87131/tde-22032011-164924/.

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A leptospirose é uma zoonose de importância global causada por espiroquetas patogênicas do gênero Leptospira. Foi avaliado o potencial adjuvante da flagelina FliCi de Salmonella enterica sorovar Thyphimurium na indução de resposta imunoprotetora em uma formulação vacinal acelular composta pela proteína LigAc e por seis prováveis lipoproteínas de membrana externa recombinantes de Leptospira interrogans sorovar Copenhageni como alternativa profilática. Grupos de hamsters imunizados com LigAc co-administrada com o pool das proteínas acrescidas de FliCi ou Al(OH)3 apresentaram altos títulos de ant

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19

Wongkuttiya, Donruedee. "Construction of DNA vaccines and recombinant salmonella vaccines against respiratory syncytial virus, and their assessment in a murine model." Thesis, University of Newcastle Upon Tyne, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366516.

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20

Schroeder, Juliane. "Selection of novel antigens from Leishmania spp. and design of live recombinant salmonella vaccines against experimental visceral leishmaniasis." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2011. http://dx.doi.org/10.18452/16308.

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Leishmaniosen gehören zu den tropischen Krankheiten und bedrohen geschätzte 350 Millionen Menschen in 88 Ländern weltweit. Die schwerste Form, viszerale Leishmaniose, betrifft die ärmsten Bevölkerungsschichten und ist die Ursache für circa 50 000 Todesfälle pro Jahr. Es wird angenommen, dass die Entwicklung eines Impfstoffs möglich ist, aber trotz aller Bemühungen, steht derzeit noch kein Impfstoff zur Verfügung. Im Rahmen dieser Arbeit wurde ein Impfstoff gegen viszerale Leishmaniose entwickelt und in vivo auf pre-klinischer Ebene getestet. Des Weiteren wurden rekombinante Membranvesikel ko

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21

Diniz, Patricia Placona. "Estudo do potencial vacinal de proteínas de Schistosoma mansoni utilizando salmonelas atenuadas recombinantes como veículo para apresentação de antígenos ao hospedeiro." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/87/87131/tde-29042010-090416/.

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A Esquistossomose é uma das mais importantes doenças endêmicas do mundo, com mais de 200 milhões de pessoas infectadas em 76 países. É estimado que mais de 600 milhões de pessoas estejam em áreas endêmicas. Em 2003 dados do transcriptoma do Schistosoma mansoni foram disponibilizados. As informações de proteínas codificadas permitiram a análise de suas funções, e auxiliaram na procura de novos candidatos vacinais. A análise do transcriptoma permitiu a identificação de três famílias de proteínas homólogas à dineína de cadeia leve (DLC) de mamíferos. Uma delas é a família L8, com ao menos 18 memb

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Schroeder, Juliane [Verfasser], R. [Akademischer Betreuer] Lucius, Tamás [Akademischer Betreuer] Laskay, and Maurice [Akademischer Betreuer] Gallagher. "Selection of novel antigens from Leishmania spp. and design of live recombinant salmonella vaccines against experimental visceral leishmaniasis / Juliane Schroeder. Gutachter: R. Lucius ; Tamás Laskay ; Maurice Gallagher." Berlin : Humboldt Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2011. http://d-nb.info/1015046452/34.

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Nakajima, Erika. "Investigação de proteínas candidatas vacinais contra leptospirose. Apresentação de antígenos na forma de proteínas recombinantes purificadas ou como vacinas vivas em salmonelas atenuadas." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/87/87131/tde-02032011-173909/.

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A leptospirose é uma doença endêmica causada por Leptospiras. O genoma da Leptospira interrogans sorovar Copenhageni foi analisado para seleção de potenciais antígenos vacinais. Oito genes foram selecionados e clonados para expressão e purificação dos antígenos. A salmonela SL3261 foi usada como carregadora dos genes de leptospira em vetor pAEsox para expressão das proteínas in vivo. As salmonelas recombinantes induziram resposta imune quando administradas em camundongos por via intraperitoneal. Hamsters foram imunizados com as salmonelas, observando-se que a SLLIC10191 induziu proteção parcia

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Sevil, Domènech Victòria [Verfasser]. "Influence of oral boost immunizations with recombinant Salmonella vaccine strains on the antigen-specific CD8 T-cell induction / vorgelegt von Victòria Sevil Domènech." 2007. http://d-nb.info/985990163/34.

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"Effects of Cyclic Adenosine Monophosphate Independent Cyclic Adenosine Monophosphate Receptor Protein in Recombinant Attenuated Salmonella Vaccines." Master's thesis, 2012. http://hdl.handle.net/2286/R.I.15223.

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abstract: Salmonella enterica is a gastrointestinal (GI) pathogen that can cause systemic diseases. It invades the host through the GI tract and can induce powerful immune responses in addition to disease. Thus, it is considered as a promising candidate to use as oral live vaccine vectors. Scientists have been making great efforts to get a properly attenuated Salmonella vaccine strain for a long time, but could not achieve a balance between attenuation and immunogenicity. So the regulated delayed attenuation/lysis Salmonella vaccine vectors were proposed as a design to seek this balance. The r

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Saron, Wilfried. "Expression chez les plantes de protéines recombinantes pour des procédures vaccinales : cas de l'Arterivirus porcin et de la flagelline de Salmonella typhimurium." Thèse, 2012. http://www.archipel.uqam.ca/4912/1/D2333.pdf.

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Ce projet avait pour but la production de protéines recombinantes pour des procédures vaccinales dans un système végétal. Les protéines choisies ont été d'une part, deux protéines virales d'un Arterivirus, le virus du syndrome reproducteur et respiratoire porcin (PRRSV), les protéines GP5 et M, et d'autre part une protéine du flagelle, la flagelline ou FljB de Salmonella typhimurium. Le PRRSV est responsable de pertes économiques majeures dans l'industrie porcine mondiale et l'efficacité des vaccins actuels contre ce virus est limitée. La protéine M a été choisie pour sa propriété à former un

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