Artykuły w czasopismach: „Rats Diseases”

1

Benato, Livia. "Respiratory diseases in rats". Companion Animal 17, nr 4 (maj 2012): 47–50. http://dx.doi.org/10.1111/j.2044-3862.2012.00163.x.

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Rao, Ghanta N. "Diet and Kidney Diseases in Rats". Toxicologic Pathology 30, nr 6 (październik 2002): 651–56. http://dx.doi.org/10.1080/01926230290166733.

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Middleton, Charles C. "Infectious Diseases of Mice and Rats. The Committee on Infectious Diseases of Mice and Rats.Companion Guide to Infectious Diseases of Mice and Rats. The Committee on Infectious Diseases of Mice and Rats." Quarterly Review of Biology 67, nr 2 (czerwiec 1992): 219. http://dx.doi.org/10.1086/417602.

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Clement, Jan, James LeDuc, Graham Lloyd, Jean-Marc Reynes, Lorraine McElhinney, Marc Van Ranst i Ho-Wang Lee. "Wild Rats, Laboratory Rats, Pet Rats: Global Seoul Hantavirus Disease Revisited". Viruses 11, nr 7 (17.07.2019): 652. http://dx.doi.org/10.3390/v11070652.

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Recent reports from Europe and the USA described Seoul orthohantavirus infection in pet rats and their breeders/owners, suggesting the potential emergence of a “new” public health problem. Wild and laboratory rat-induced Seoul infections have, however, been described since the early eighties, due to the omnipresence of the rodent reservoir, the brown rat Rattus norvegicus. Recent studies showed no fundamental differences between the pathogenicity and phylogeny of pet rat-induced Seoul orthohantaviruses and their formerly described wild or laboratory rat counterparts. The paucity of diagnosed Seoul virus-induced disease in the West is in striking contrast to the thousands of cases recorded since the 1980s in the Far East, particularly in China. This review of four continents (Asia, Europe, America, and Africa) puts this “emerging infection” into a historical perspective, concluding there is an urgent need for greater medical awareness of Seoul virus-induced human pathology in many parts of the world. Given the mostly milder and atypical clinical presentation, sometimes even with preserved normal kidney function, the importance of simple but repeated urine examination is stressed, since initial but transient proteinuria and microhematuria are rarely lacking.

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HART, BENJAMIN L., ELIZABETH K. KORINEK i PATRICIA L. BRENNAN. "Postcopulatory Grooming in Male Rats Prevents Sexually Transmitted Diseases". Annals of the New York Academy of Sciences 525, nr 1 Neural Mechan (maj 1988): 397–98. http://dx.doi.org/10.1111/j.1749-6632.1988.tb38624.x.

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Wang, Ruwen, Haili Tian, Dandan Guo, Qianqian Tian, Ting Yao i Xingxing Kong. "Impacts of exercise intervention on various diseases in rats". Journal of Sport and Health Science 9, nr 3 (maj 2020): 211–27. http://dx.doi.org/10.1016/j.jshs.2019.09.008.

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Casili, Giovanna, Alessio Ardizzone, Marika Lanza, Enrico Gugliandolo, Marco Portelli, Angela Militi, Salvatore Cuzzocrea, Emanuela Esposito i Irene Paterniti. "Treatment with Luteolin Improves Lipopolysaccharide-Induced Periodontal Diseases in Rats". Biomedicines 8, nr 10 (21.10.2020): 442. http://dx.doi.org/10.3390/biomedicines8100442.

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Periodontitis is a dental disease that produces the progressive destruction of the bone surrounding the tooth. Especially, lipopolysaccharide (LPS) is involved in the deterioration of the alveolar bone, inducing the release of pro-inflammatory mediators, which cause periodontal tissue inflammation. Luteolin (Lut), a molecule of natural origin present in a large variety of fruits and vegetables, possess beneficial properties for human health. On this basis, we investigated the anti-inflammatory properties of Lut in a model of periodontitis induced by LPS in rats. Animal model predicted a single intragingival injection of LPS (10 μg/μL) derived from Salmonella typhimurium. Lut administration, was performed daily at different doses (10, 30, and 100 mg/kg, orally), starting from 1 h after the injection of LPS. After 14 days, the animals were sacrificed, and their gums were processed for biochemical analysis and histological examinations. Results showed that Lut (30 and 100 mg/kg) was equally able to reduce alveolar bone loss, tissue damage, and neutrophilic infiltration. Moreover, Lut treatment reduced the concentration of collagen fibers, mast cells degranulation, and NF-κB activation, as well as the presence of pro-inflammatory enzymes and cytokines. Therefore, Lut implementation could represent valid support in the pharmacological strategy for periodontitis, thus improving the well-being of the oral cavity.

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ABRAMSKY, O., E. WERTMAN, A. RECHES, T. BRENNER i H. OVADIA. "Effect of Hypothalamic Lesions on Experimental Autoimmune Diseases in Rats". Annals of the New York Academy of Sciences 496, nr 1 Neuroimmune I (maj 1987): 360–65. http://dx.doi.org/10.1111/j.1749-6632.1987.tb35788.x.

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SASA, Hiroaki, Yukiya HASHIMOTO, Takako SHIMIZU i Ken-ichi INUI. "Hepatic Extraction of Tacrolimus in Rats with Experimental Liver Diseases." Biological & Pharmaceutical Bulletin 21, nr 6 (1998): 610–14. http://dx.doi.org/10.1248/bpb.21.610.

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Cintra, Luciano Tavares Angelo, Aguinaldo Cândido da Silva Facundo, Mariane Maffei Azuma, Dóris Hissako Sumida, Rafael Dias Astolphi, Suely Regina Mogami Bomfim, Luís Gustavo Narciso i João Eduardo Gomes-Filho. "Pulpal and periodontal diseases increase triglyceride levels in diabetic rats". Clinical Oral Investigations 17, nr 6 (5.10.2012): 1595–99. http://dx.doi.org/10.1007/s00784-012-0853-7.

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CANDIDO, E., C. CARVALHO, F. MARTINEZ i V. CAGNON. "Experimental alcoholism and pathogenesis of prostatic diseases in UChB rats". Cell Biology International 31, nr 5 (maj 2007): 459–72. http://dx.doi.org/10.1016/j.cellbi.2006.11.009.

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Baykal, Asli, Figen S. arigul, Gultekin Suleymanla, Paula I. Moreira, George Perry, Mark A. Smith i Yakup Aliciguzel. "Ciprofloxacin Does Not Exert Nephrotoxicity in Rats". American Journal of Infectious Diseases 1, nr 3 (1.03.2005): 145–48. http://dx.doi.org/10.3844/ajidsp.2005.145.148.

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Zhao, Na, Zhidan Sun, Ulrich Egert, Yuying Mao, Pengzhou Hang, Xing Jiang, Lihua Sun, Jinlong Zhao i Zhimin Du. "Myocardial Iron Metabolism in the Regulation of Cardiovascular Diseases in Rats". Cellular Physiology and Biochemistry 25, nr 6 (2010): 587–94. http://dx.doi.org/10.1159/000315077.

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Galvão, Mariane Ponzio de Azevedo, Ana Chapper, Cassiano Kuchenbecker Rösing, Maria Beatriz Cardoso Ferreira i Maria Antonieta Lopes de Souza. "Methodological considerations on descriptive studies of induced periodontal diseases in rats". Pesquisa Odontológica Brasileira 17, nr 1 (marzec 2003): 56–62. http://dx.doi.org/10.1590/s1517-74912003000100011.

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The aim of this study was to show the technique and the methodological approach used in describing histological characteristics of induced periodontal disease in rats. To reach that inflammatory process, periodontal disease was induced by ligature, with or without sucrose-rich diet. Twenty-four female adult (60 days old) Wistar rats were divided in four groups: Group 1, or control (which received standard diet), Group 2 (which received ligature around the upper second molars and a standard diet), Group 3 (which received a sucrose-rich diet), and Group 4 (which received ligature around the upper second molars and a sucrose-rich diet). The animals were followed for a period of 30 days, after which they were sacrificed. The upper second molars were removed, processed, and the histological characteristics were analyzed by a descriptive dichotomous method. The results were analyzed by the Fisher's exact test (significance level of 95%) and by a residual test, which showed the relation between groups and histological characteristics. The animals which received ligature (Groups 2 and 4) showed histological characteristics related with periodontitis, whilst the animals without ligatures showed no periodontal destruction. This was shown by a distribution of these groups in extremes of a graphic representation. The use of a ligature, as done in this study, was able to promote a chronic inflammatory process in the periodontium of rats, regardless of the adopted diet. The correspondence factorial analysis was capable of showing these characteristics, being one more tool to be used in histological research.

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15

KIMURA, Toshikiro, Seiya NAKAYAMA, Tadanao YAMAO, Yuji KUROSAKI i Taiji NAKAYAMA. "Pharmacokinetics of Indocyanine Green in Rats with Experimentally Induced Hepatic Diseases." Biological & Pharmaceutical Bulletin 16, nr 11 (1993): 1140–45. http://dx.doi.org/10.1248/bpb.16.1140.

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Orbak, R., C. Kara, E. Özbek, A. Tezel i T. Demir. "Effects of zinc deficiency on oral and periodontal diseases in rats". Journal of Periodontal Research 42, nr 2 (kwiecień 2007): 138–43. http://dx.doi.org/10.1111/j.1600-0765.2006.00939.x.

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G.O., Khidirova, Khasanov K.D., Erkinova Dilrabo i Abdurakhmanova Nafosat. "MORPHOLOGICAL STRUCTURE OF THE FEMUR IN WHITE RATS WITH HYPOPARATHYROIDISM". American Journal of Medical Sciences and Pharmaceutical Research 04, nr 04 (1.04.2022): 11–15. http://dx.doi.org/10.37547/tajmspr/volume04issue04-03.

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The disease of the musculoskeletal system in children of the first months of life is quite a lot, deformities of the lower extremities are most common. The reason for the observed deformities of the lower extremities is the delay in the development of the bone skeleton during fetal life, due to heredity, infectious diseases of the mother during pregnancy, endocrine pathologies, toxicosis (especially the first half of pregnancy). Many authors, studying the endocrine status of patients with deformities of the lower extremities, came to the conclusion that this pathology is hormonal and mainly develops in the late period of the child's intrauterine life [1, 2, 4, 5 ].

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18

LOTH, Eduardo Alexandre, Vanessa CECATTO, Samia Khalil BIAZIM, José Henrique Fermino FERREIRA, Caroline DANIELLI, Rodrigo Daniel GENSKE, Rinaldo Ferreira GANDRA i Marcello Fabiano de FRANCO. "EXPERIMENTAL PARACOCCIDIOIDOMYCOSIS IN PREGNANT RATS". Revista do Instituto de Medicina Tropical de São Paulo 57, nr 6 (grudzień 2015): 515–18. http://dx.doi.org/10.1590/s0036-46652015000600010.

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Paracoccidioidomycosis (PCM), caused by the dimorphic fungus Paracoccidioides brasiliensis (Pb), is the most prevalent systemic mycosis in Latin America. There are few reports in the literature about the disease damages during pregnancy and the consequences to the fetuses and breeding. This study evaluated the implications of PCM during pregnancy on offspring and mothers in Wistar rats. Groups of rats were submitted to systemic Pb infection, by intraperitoneal infusion, and mated 30 days after the infection date. Immediately after birth, rats and neonates were sacrificed to obtain organs for standard histological examination, morphometric analysis, fungi recovery by plating (CFU) and dosing of anti-Pb antibodies by ELISA. There were no stillbirths or miscarriages, however, the fetuses from infected pregnant rats had lower body and organ weight but the fertility rate was 100%. The largest number of CFU was recovered from the organ of pregnant rats, the pathological examination revealed more severe infection in the same group, further on the largest number of granulomas and fungal field. It can be concluded that the PCM was more severe in the group of pregnant rats, with implications to the weight of offspring.

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19

Nakamura, Y., T. Masuhara, S. Ito-Kuwa i S. Aoki. "Induction of experimentalCandidaarthritis in rats". Medical Mycology 29, nr 3 (styczeń 1991): 179–92. http://dx.doi.org/10.1080/02681219180000281.

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Oliynyk, Zh. "LONG-TERM EFFECTS OF SHAM SURGERY ON PHAGOCYTE FUNCTIONS IN RATS". Biotechnologia Acta 15, nr 2 (kwiecień 2022): 37–46. http://dx.doi.org/10.15407/biotech15.02.037.

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Animal models of inflammatory disorders, including those of the nervous system are commonly used to explore the pathophysiological role of immune cell response in disease triggering and course and to develop biotechnology products for therapeutic use. Modeling some of these disorders, particularly neurodegenerative diseases, implies surgical manipulations for the intracerebral introduction of disease-initiating substances (toxins, amyloids etc.). Design of these experiments involves the use of sham-operated animals as a control of non-specific intrinsic side-effects elicited by surgical manipulations per se, including local and systemic inflammation, where phagocytic cells are key participants. Short-term post-surgical immunomodulatory effects are widely reported. However, no study thus far has examined the long term effects of sham-surgery on phagocyte functions. The purpose of this study was to evaluate the effect of sham-surgery, commonly used for modeling neurodegenerative diseases, on phagocyte functions in the far terms after the surgical manipulations. Materials and Methods. Adult male Wistar rats were used in the study. Sham surgery consisted of stereotactic unilateral injection of saline solution into the median forebrain bundle (sham-operated 1, SO1) or directly into the substantia nigra (sham-operated 2, SO2). Before the placebo surgery, animals were anaesthetized using nembutal and ketamine/xylazine correspondingly. Functional characteristics (phagocytic activity, oxidative metabolism, CD80/86 and CD206 expression) of phagocytes (microglia, peritoneal macrophages, circulating monocytes and granulocytes) were examined by flow cytometry. Differential leukocyte count was conducted using hematological analyzer. Results. Phagocytes from animals underwent of different protocols of placebo surgery, demonstrated various patterns of functional changes on day 29 after the manipulations. In animals from SO1 group, we observed signs of residual neuroinflammation (pro-inflammatory shift of microglia functional profile) along with ongoing resolution of systemic inflammation (anti-inflammatory metabolic shift of circulating phagocytes and peritoneal macrophages). In rats from SO2 group, pro-inflammatory polarized activation of peritoneal phagocytes was registered along with anti-inflammatory shift in microglia and circulating phagocytes. Conclusions. Sham surgery influences functions of phagocytic cells of different locations even in the far terms after the manipulations. These effects can be considered as combined long-term consequences of surgical brain injury and the use of anesthetics. Our observations evidences, that sham associated non-specific immunomodulatory effects should always be taken into consideration in animal models of inflammatory central nervous system diseases.

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21

Güngör, M., H. Sagduyu, H. Koyuncuoglu, Ö. Ang, V. Uysal, D. Inanç i M. Ang. "Comparison of the development of experimental pyelonephritis in homozygous brattleboro diabetes insipidus rats, heterozygous control rats and normal wistar rats". Infection 13, nr 2 (marzec 1985): 82–84. http://dx.doi.org/10.1007/bf01660420.

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Hong, S. T., B. I. Kim, W. G. Kho, J. R. Yu, J. Kook, J. Y. Chai, C. K. Yun i S. H. Lee. "Karyotypes of Pneumocystis carinii from Korean rats". Korean Journal of Parasitology 30, nr 3 (1992): 183. http://dx.doi.org/10.3347/kjp.1992.30.3.183.

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Hong, S. T. "PCR in diagnosis of pneumocystosis of rats". Korean Journal of Parasitology 34, nr 3 (1996): 191. http://dx.doi.org/10.3347/kjp.1996.34.3.191.

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Sengor, B., D. Bayramgurler, B. Muezzinoglu, L. Altintas, N. Bilen i R. Apaydin. "Effects of acitretin on spermatogenesis of rats". Journal of the European Academy of Dermatology and Venereology 20, nr 6 (lipiec 2006): 689–92. http://dx.doi.org/10.1111/j.1468-3083.2006.01573.x.

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Galbe, Jordi L., Edward Guy, Jose M. Zapatero, Ellinor I. B. Peerschke i Jorge L. Benach. "Vascular clearance of Borrelia burgdorferi in rats". Microbial Pathogenesis 14, nr 3 (marzec 1993): 187–201. http://dx.doi.org/10.1006/mpat.1993.1019.

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Gottberg, Carlos F., Jose H. Donis, Argenis Torres, Abdel J. Fuenmayor i Diego F. Davila. "Heart rate changes in rats with acute Chagasic myocarditis". Transactions of the Royal Society of Tropical Medicine and Hygiene 82, nr 6 (listopad 1988): 851. http://dx.doi.org/10.1016/0035-9203(88)90014-4.

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Schmidt, A. "Systemic candidiasis in Sprague-Dawley rats". Medical Mycology 34, nr 2 (styczeń 1996): 99–104. http://dx.doi.org/10.1080/02681219680000151.

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Sobel, Jack D., Gregory Muller i John F. McCormick. "Experimental chronic vaginal candidosis in rats". Medical Mycology 23, nr 3 (styczeń 1985): 199–206. http://dx.doi.org/10.1080/00362178585380301.

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Komninou, Despina, Virginia L. Malloy, Jay A. Zimmerman, Raghu Sinha i John P. Richie. "Methionine restriction delays aging-related urogenital diseases in male Fischer 344 rats". GeroScience 42, nr 1 (14.11.2019): 287–97. http://dx.doi.org/10.1007/s11357-019-00129-4.

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Quiros, J., J. Gonzalez-cabrerot, G. Herrero-beaumont i J. Egido. "Elevated Plasma Fibronectin Levels in Rats with Immune and Toxic Glomerular Diseases". Renal Failure 12, nr 4 (styczeń 1990): 227–32. http://dx.doi.org/10.3109/08860229009060729.

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Zykova, Svetlana, Sergey Shurov, Aleksey Savinkov, Nino Gugushvili i Vladimir Talismanov. "Pharmacoprophylaxis of liver diseases: creating a new hepatoprotector". BIO Web of Conferences 17 (2020): 00061. http://dx.doi.org/10.1051/bioconf/20201700061.

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The article presents a study of the hepatoprotective activity of a tricyclic heterocycle, which refers to 5, 6, 7, 8-tetrahydroquinolines. The effect of 8, 8-dimethyl-5-p-tolyl-8, 9-dihydro-2H-pyrido [4, 3, 2-de] cinnolin-3 (7H) was studied on rats under the influence of the model of toxic hepatosis induced by carbon tetrachloride to find out the indicators of peroxidation and biochemical indicators. Biochemical studies have shown that modelling toxic fat hepatosis caused by the inception of carbon tetrachloride to rats increased the activity of alanine aminotransferase by 2.5 times more compared with the intact group, indicating the development of oxidative stress induced by the treatment of pyrido [4, 3, 2] Cinnol I that reduced the toxic effect of CTC by 79.9 %. Mexidol had a less pronounced hepatoprotective effect: the activity of Alanine aminotransferase on animals of the second group was lower by 29.2 % than on rats from the control group. Thus, a new compound with hepatoprotective activity has been developed and studied.

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Yasuda, Shumpei P., Kenta Shimizu, Takaaki Koma, Nguyen Thuy Hoa, Mai Quynh Le, Zhuoxing Wei, Devinda S. Muthusinghe i in. "Immunological Responses to Seoul Orthohantavirus in Experimentally and Naturally Infected Brown Rats (Rattus norvegicus)". Viruses 13, nr 4 (12.04.2021): 665. http://dx.doi.org/10.3390/v13040665.

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To clarify the mechanism of Seoul orthohantavirus (SEOV) persistence, we compared the humoral and cell-mediated immune responses to SEOV in experimentally and naturally infected brown rats. Rats that were experimentally infected by the intraperitoneal route showed transient immunoglobulin M (IgM) production, followed by an increased anti-SEOV immunoglobulin G (IgG) antibody response and maturation of IgG avidity. The level of SEOV-specific cytotoxic T lymphocytes (CTLs) peaked at 6 days after inoculation and the viral genome disappeared from serum. In contrast, naturally infected brown rats simultaneously had a high rate of SEOV-specific IgM and IgG antibodies (28/43). Most of the IgM-positive rats (24/27) had the SEOV genome in their lungs, suggesting that chronic SEOV infection was established in those rats. In female rats with IgG avidity maturation, the viral load in the lungs was decreased. On the other hand, there was no relationship between IgG avidity and viral load in the lungs in male rats. A CTL response was not detected in naturally infected rats. The difference between immune responses in the experimentally and naturally infected rats is associated with the establishment of chronic infection in natural hosts.

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Hong, S. J., H. C. Woo, J. Y. Chai, S. W. Chung, S. H. Lee i B. S. Seo. "Study on Centrocestus armatus in Korea. II. Recovery rate, growth and development of worms in albino rats". Korean Journal of Parasitology 27, nr 1 (1989): 47. http://dx.doi.org/10.3347/kjp.1989.27.1.47.

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Hong, S. J., H. C. Woo, S. Y. Lee, J. H. Ahn, C. K. Park, J. Y. Chai i S. H. Lee. "Worm recovery rate and small intestinal lesions of albino rats coinfected with Fibricola seoulensis and Metagonimus yokogawai". Korean Journal of Parasitology 31, nr 2 (1993): 109. http://dx.doi.org/10.3347/kjp.1993.31.2.109.

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Ohta, Takeshi, Yoshiaki Katsuda, Katsuhiro Miyajima, Tomohiko Sasase, Shuichi Kimura, Bin Tong i Takahisa Yamada. "Gender Differences in Metabolic Disorders and Related Diseases in Spontaneously Diabetic Torii-LeprfaRats". Journal of Diabetes Research 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/841957.

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The Spontaneously Diabetic ToriiLeprfa(SDT fatty) rat is a novel type 2 diabetic model wherein both male and female rats develop glucose and lipid abnormalities from a young age. In this study, we investigated gender differences in abnormalities and related complications in SDT fatty rats. Food intake was higher in males compared to female rats; however, body weight was not different between genders. Progression of diabetes, including increases in blood glucose and declines in blood insulin, was observed earlier in male rats than in females, and diabetic grade was more critical in male rats. Blood lipids tended to increase in female rats. Gonadal dysfunction was observed in both male and female rats with aging. Microangiopathies, such as nephropathy, retinopathy, neuropathy, and osteoporosis, were seen in both genders, and pathological grade and progression were more significant in males. Qualitative and quantitative changes were observed for metabolic disease gender differences in SDT fatty rats. The SDT fatty rat is a useful model for researching gender differences in metabolic disorders and related diseases in diabetes with obesity.

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Hong, Sung-Tae, Yun-Kyu Park, Jin Kim, Dug-Ha Kim i Chong-Ku Yun. "Is Pneumocystis carinii vertically transmitted to neonatal rats?" Korean Journal of Parasitology 37, nr 3 (1999): 149. http://dx.doi.org/10.3347/kjp.1999.37.3.149.

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Nielsen, Susanne Schouw, Thorbjørn Grøfte, Niels Tygstrup i Hendrik Vilstrup. "Cirrhosis and endotoxin decrease urea synthesis in rats". Hepatology Research 37, nr 7 (lipiec 2007): 540–47. http://dx.doi.org/10.1111/j.1872-034x.2007.00076.x.

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Lian-Chen, Wang, Chao David i Chen Eng-Rin. "Acquired immunity in rats against Angiostrongylus cantonensis infection". International Journal for Parasitology 19, nr 6 (wrzesień 1989): 617–20. http://dx.doi.org/10.1016/0020-7519(89)90039-8.

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Weissenbacher, Mercedes C., Eduardo F. Lascano, María M. Avila i María I. Berría. "Chronic Neurologic Disease in Junín Virus-Infected Rats". Journal of Medical Virology 20, nr 1 (wrzesień 1986): 57–65. http://dx.doi.org/10.1002/jmv.1890200108.

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Temma, Takashi, Kazuhiro Koshino, Tetsuaki Moriguchi, Jun-ichiro Enmi i Hidehiro Iida. "PET Quantification of Cerebral Oxygen Metabolism in Small Animals". Scientific World Journal 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/159103.

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Understanding cerebral oxygen metabolism is of great importance in both clinical diagnosis and animal experiments because oxygen is a fundamental source of brain energy and supports brain functional activities. Since small animals such as rats are widely used to study various diseases including cerebral ischemia, cerebrovascular diseases, and neurodegenerative diseases, the development of a noninvasivein vivomeasurement method of cerebral oxygen metabolic parameters such as oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (CMRO2) as well as cerebral blood flow (CBF) and cerebral blood volume (CBV) has been a priority. Although positron emission tomography (PET) with15O labeled gas tracers has been recognized as a powerful way to evaluate cerebral oxygen metabolism in humans, this method could not be applied to rats due to technical problems and there were no reports of PET measurement of cerebral oxygen metabolism in rats until an15O-O2injection method was developed a decade ago. Herein, we introduce an intravenous administration method using two types of injectable15O-O2and an15O-O2gas inhalation method through an airway placed in the trachea, which enables oxygen metabolism measurements in rats.

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Stahlmann, R., S. Klug, C. Lewandowski, I. Chahoud, G. Bochert, H. J. Merker i D. Neubert. "Teratogenicity of acyclovir in rats". Infection 15, nr 4 (lipiec 1987): 261–62. http://dx.doi.org/10.1007/bf01644129.

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Shinozaki, Kazuya, Atsunori Kashiwagi, Masahiro Masada i Tomio Okamura. "Tetrahydrobiopterin and Endothelial Dysfunction in Cardiovascular Diseases". Pteridines 17, nr 1 (luty 2006): 11–15. http://dx.doi.org/10.1515/pteridines.2006.17.1.11.

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Abstract Endothelial vasodilator dysfunction is a characteristic feature of patients at risk for coronary atheroscierosis. We have reported that insulin resistance may be a pathogenic factor for endothehal dysfunction through impaired endothelial nitric oxide synthase (eNOS) activity and increased oxidative breakdown of nitric oxide (NO) due to an enhanced fonnation of Superoxide anion, which arc caused by relative deficiency of tetrahydrobiopterin (BH4) in vascular endothelial cclls. Guanosine-triphosphate cyclohydrolase I, the rate-limiting cnzyme in the production of BH4, is decreased in the aorta of insulin-resistant rats and supplementation of BH4 restored the endothelial function and relieved oxidative tissue damage. The BH4 treatment may evoke these benefits not only by providing eNOS with cofactor to enhance NO synthesis, but also by acting as an indirect and/or direct antioxidant to decrease Superoxide anion derived from the endothelium. A further understanding of the physiological and pathological roles and their regulation may lead to new therapeutic avenues.

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YOUSFI, Mimoun EL, Denis BREUILLÉ, Isabelle PAPET, Stéphanie BLUM, Marc ANDRÉ, Laurent MOSONI, Philippe DENIS, Caroline BUFFIÈRE i Christiane OBLED. "Increased tissue protein synthesis during spontaneous inflammatory bowel disease in HLA-B27 rats". Clinical Science 105, nr 4 (1.10.2003): 437–46. http://dx.doi.org/10.1042/cs20020313.

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Inflammatory bowel diseases (IBDs) are associated with an increased whole-body protein turnover. In certain drug-induced experimental models of IBD, disturbances of protein synthesis in tissues have been reported recently, but it is unclear if similar disturbances occur in other chronic intestinal diseases. Therefore we investigated changes in protein synthesis in different tissues of HLA-B27 (human leucocyte antigen B27) transgenic rats that develop spontaneously chronic inflammation, with major involvement of the colon. Protein synthesis rate in HLA-B27 rats was shown to be higher in nine different tissues compared with control (Fisher 344) rats. The absolute rate of protein synthesis was highly stimulated at the main inflammatory site (+290% in the colon). However, liver, muscle and skin appeared to be major contributors to the increased protein synthesis observed at the whole-body level. Despite the increased protein synthesis, HLA-B27 rats presented a marked atrophy of muscles, which suggests an increased proteolysis. These results contrast with metabolic disturbances described in acute inflammation and colitis induced by drugs (i.e. dextran sodium sulphate). The present study suggests that the modifications of protein metabolism are strongly influenced by the type of the inflammatory diseases and thus by the underlying mechanisms, which result in different metabolic adaptations and specific nutritional requirements.

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Berahmand, Farnoosh, Golnoush Anoush, Mir-Jamal Hosseini i Mahdieh Anoush. "Grape Seed Oil as a Natural Therapy in Male Rats with Alzheimer’s Diseases". Advanced Pharmaceutical Bulletin 10, nr 3 (11.05.2020): 430–36. http://dx.doi.org/10.34172/apb.2020.052.

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Purpose: Alzheimer’s disease (AD) is a chronic neurodegenerative disorder, with an increasing prevalence rate, mostly related to cholinergic system. According to the difficulties and complications in management of AD, this study was carried out to evaluate the efficacy of grape seed oil (GSO) on scopolamine (Scop) induced Alzheimer’s in male rats. Methods: 64 healthy male Wistar rats received different treatments such as: normal saline (NS), donepezil (Don), Scop and GSO, according to the previously designed protocol. Morris (MWM) was applied for spatial memory tests. Right after the behavioral tests, the brains were removed and the hippocampus was separated for evaluation of acetylcholine levels as well as cell death and neuro inflammation. Results: The results of the test day indicated that the mean Q2 time was increased in both GSO test groups (P<0.05) and Don treated group (P<0.001).The spectrophotometric findings affirm that both GSO co-treatment and post-treatment were effective in augmenting brain acetylcholine levels (P<0.01 and P<0.05 respectively). The microscopic findings of Hamp;E dyed tissues confirmed the above mentioned results for different treatments except for GSO post treatment, in which the viability of cells were very low. Conclusion: The results implied that supplementation of rats with GSO caused a significant augmentation in spatial memory performance as well as acetylcholine levels and cell viability in the presence of Scop. This effect was comparable to that of Don especially when GSO was used as co-treatment.

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Lee, Unji, Young H. Choi, So H. Kim i Byung K. Lee. "Pharmacokinetics of Itraconazole in Diabetic Rats". Antimicrobial Agents and Chemotherapy 54, nr 2 (7.12.2009): 931–33. http://dx.doi.org/10.1128/aac.01145-09.

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ABSTRACT After intravenous or oral administration of 10 mg/kg itraconazole to rats with streptozotocin-induced diabetes mellitus and to control rats, the total area under the plasma concentration-time curve from time 0 to 24 h (AUC0-24) for itraconazole and that for its metabolite, 7-hydroxyitraconazole, were similar between the two groups of rats. This may be explained by the comparable hepatic and intestinal intrinsic clearance rates for the disappearance of itraconazole and the formation of 7-hydroxyitraconazole in both groups of rats.

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Lister, P. D., M. J. Gentry i L. C. Preheim. "Granulocyte Colony-Stimulating Factor Protects Control Rats but Not Ethanol-Fed Rats from Fatal Pneumococcal Pneumonia". Journal of Infectious Diseases 168, nr 4 (1.10.1993): 922–26. http://dx.doi.org/10.1093/infdis/168.4.922.

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TORRES, Argenis, Diego F. DÁVILA, Carlos F. GOTTBERG, Jose H. DONIS, Gabriela ARATA DE BELLABARBA i Paolo RAMONI-PERAZZI. "Heart rate responses to a muscarinic agonist in rats with experimentally induced acute and subacute chagasic myocarditis". Revista do Instituto de Medicina Tropical de São Paulo 42, nr 4 (sierpień 2000): 219–24. http://dx.doi.org/10.1590/s0036-46652000000400007.

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We administered arecoline to rats, with experimentally induced chagasic myocarditis, in order to study the sinus node sensitivity to a muscarinic agonist. Sixteen month old rats were inoculated with 200,000 T. cruzi parasites ("Y" strain). Between days 18 and 21 (acute stage), 8 infected rats and 8 age-matched controls received intravenous arecoline as a bolus injection at the following doses: 5.0, 10.0, 20.0, 40.0, and 80.0 mug/kg. Heart rate was recorded before, during and after each dose of arecoline. The remaining 8 infected animals and 8 controls were subjected to the same experimental procedure during the subacute stage, i.e., days 60 to 70 after inoculation. The baseline heart rate, of the animals studied during the acute stage (349 ± 68 bpm, mean ± SD), was higher than that of the controls (250 ± 50 bpm, p < 0.005). The heart rate changes were expressed as percentage changes over baseline values. A dose-response curve was constructed for each group of animals. Log scales were used to plot the systematically doubled doses of arecoline and the induced-heart rate changes. The slope of the regression line for the acutely infected animals (r = - 0.99, b =1.78) was not different from that for the control animals (r = - 0.97, b = 1.61). The infected animals studied during the subacute stage (r = - 0.99, b = 1.81) were also not different from the age-matched controls (r = - 0.99, b = 1.26, NS). Consequently, our results show no pharmacological evidence of postjunctional hypersensitivity to the muscarinic agonist arecoline. Therefore, these results indirectly suggest that the postganglionic parasympathetic innervation, of the sinus node of rats with autopsy proved chagasic myocarditis, is not irreversibly damaged by Trypanosoma cruzi.

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Liu, Zhaoheng, Wei Wang, Fang Cao, Shuo Liu, Xinxin Zou, Guodong Li, Haojie Yang i Yang Jiao. "Number 2 Feibi Recipe Reduces PM2.5-Induced Lung Injury in Rats". Evidence-Based Complementary and Alternative Medicine 2018 (2018): 1–10. http://dx.doi.org/10.1155/2018/3674145.

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Air pollution is the main cause of respiratory diseases. Fine particulates with the diameter below 2.5 μm can get into the alveoli and then enter the blood circulation through the lung tissue ventilation function and cause multiple systemic diseases especially the respiratory diseases. This study investigated the pathological mechanism of the lungs injury in rats induced by PM2.5 and the effect and mechanism of the Chinese herbal medicine number 2 Feibi Recipe (number 2 FBR) on lungs injury. In this experiment, Wistar rats were used. Lungs injury was induced by PM2.5. Number 2 FBR was used to treat the rats. The result showed that number 2 FBR could improve the lung injury in the rats. Meanwhile, it significantly reduced pathological response and inflammatory mediators including interleukin-6 (IL-6), interleukin-13 (IL-13), interleukin-17 (IL17), monocyte chemotactic protein-1 (MCP-1), and transforming growth factor-α (TNF-α) and upregulated glutathione peroxidase (GSH-Px) in the PM2.5 induced lung injury in the rats. Collectively, number 2 FBR appears to attenuate the lungs injury in rats induced by PM2.5.

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Bereznyakova, A. I., i V. F. Cheremisina. "Acid-based state of blood and mixture folds in rats with parodontal diseases". Fiziolohichnyĭ zhurnal 64, nr 1 (20.02.2018): 66–72. http://dx.doi.org/10.15407/fz64.01.066.

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ITOH, Tomoo, Yasufumi SAWADA, TsuHan LIN, Tatsuji IGA i Manabu NANANO. "Kinetic analysis of phenytoin disposition in rats with experimental renal and hepatic diseases." Journal of Pharmacobio-Dynamics 11, nr 5 (1988): 289–308. http://dx.doi.org/10.1248/bpb1978.11.289.

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