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Clyde-Smith, Jodi. "Characterization of ras isoform activation by ras guanine nucleotide exchange factors /". St. Lucia, Qld, 2002. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe16393.pdf.
Pełny tekst źródłaIritani, Brian Masao. "Control of B lymphocyte development by Ras and Raf /". Thesis, Connect to this title online; UW restricted, 1997. http://hdl.handle.net/1773/8322.
Pełny tekst źródłaChan, Yuk-shing, i 陳旭勝. "Expression of RAs-related Nuclear (RAN) protein in breast cancer". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B44671003.
Pełny tekst źródłaCastillo, Chabeco Boris. "Redox Regulation of Ras Proteins in Dictyostelium discoideum". FIU Digital Commons, 2015. http://digitalcommons.fiu.edu/etd/1864.
Pełny tekst źródłaIuga, Adriana. "Solid-state 31P NMR of nucleotide binding proteins". [S.l. : s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=973225238.
Pełny tekst źródłaMcGee, John Hanney. "Evolving a Direct Inhibitor of the Ras Proteins". Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:10915.
Pełny tekst źródłaWorth, Graham Alan. "The energetics of nucleotide binding to RAS proteins". Thesis, University of Oxford, 1992. http://ora.ox.ac.uk/objects/uuid:44524415-2f2b-4601-998c-56110f332153.
Pełny tekst źródłaWilkins, Andrew. "The function of Ras proteins in Dictyostelium discoideum". Thesis, University College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313544.
Pełny tekst źródłaNaim, Adnan. "The Role of G3BPs in the Stress Response Pathway". Thesis, Griffith University, 2016. http://hdl.handle.net/10072/367499.
Pełny tekst źródłaThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Natural Sciences
Science, Environment, Engineering and Technology
Full Text
De, Cristofano Sabrina. "The role of Ras and Kinase Suppressor of Ras 1 (KSR-1) in breast cancer in progression and metastasis /". Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=112613.
Pełny tekst źródłaBramble, Sharyl Elizabeth. "Guanine nucleotide binding properties and attempted immunopurification of ras protein from dictyostelium discoideum". Thesis, University of British Columbia, 1987. http://hdl.handle.net/2429/26172.
Pełny tekst źródłaScience, Faculty of
Microbiology and Immunology, Department of
Graduate
Schroder, Wayne Ashley. "Cloning and Characterisation of the Human SinRIP Proteins". Thesis, Griffith University, 2003. http://hdl.handle.net/10072/366190.
Pełny tekst źródłaThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Biomolecular and Biomedical Sciences
Faculty of Science
Full Text
Martins, Carla Pedro. "Cip/Kip proteins in the suppression of murine lymphomagenesis". [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2003. http://dare.uva.nl/document/67628.
Pełny tekst źródłaLiu, Li. "Purification and characterization of a protein palmitoyltransferase that acts on H-Ras protein and on a C-terminal N-Ras peptide /". Thesis, Connect to this title online; UW restricted, 1996. http://hdl.handle.net/1773/8664.
Pełny tekst źródłaRoy, Sandrine. "An Investigation of the interaction of Ras with Cell membranes /". St. Lucia, Qld, 2001. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe16356.pdf.
Pełny tekst źródłaGibson, Janet Rae. "A study of RAS p21 and related GTP-binding proteins". Thesis, University of East Anglia, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.293243.
Pełny tekst źródłaSchroder, Wayne Ashley, i n/a. "Cloning and Characterisation of the Human SinRIP Proteins". Griffith University. School of Biomolecular and Biomedical Science, 2003. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20030829.140754.
Pełny tekst źródłaSeifert, Jason Paul Harden T. Kendall. "Regulation of phospholipase C-epsilon by Rho and Ras family proteins". Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2007. http://dc.lib.unc.edu/u?/etd,1008.
Pełny tekst źródłaTitle from electronic title page (viewed Dec. 18, 2007). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Pharmacology." Discipline: Pharmacology; Department/School: Medicine.
Tuxworth, Richard Ian. "The control of cell motility and differentiation by Ras pathways". Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.314227.
Pełny tekst źródłaWang, Kai Ling. "Identification and characterisation of a Ras-related GTP-binding protein, Tal-A, purified from human erythrocyte membranes". Thesis, The University of Sydney, 1997. https://hdl.handle.net/2123/29249.
Pełny tekst źródłaBruce, Emily Adaline. "Role of the Rab11 pathway in influenza virus assembly and budding". Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610519.
Pełny tekst źródłaTrowbridge, Amanda J. "Expression of SNAP23 and Rab3A in mouse oocytes and fertilized eggs and their role in cortical granules exocytosis". Virtual Press, 2004. http://liblink.bsu.edu/uhtbin/catkey/1307377.
Pełny tekst źródłaDepartment of Biology
McCollam-Guilani, Linda Sue. "Analysis of the Mechanism of Ras Activation: Mapping of Important Functional Domains of the Son of Sevenless Protein". eScholarship@UMMS, 1998. https://escholarship.umassmed.edu/gsbs_diss/90.
Pełny tekst źródłaProber, David Aaron. "Regulation of cell growth and cell identity by Ras 1 in the developing Drosophila melanogaster wing /". Thesis, Connect to this title online; UW restricted, 2002. http://hdl.handle.net/1773/4988.
Pełny tekst źródłaBROGGI, SERENA. "Studies on active RAS proteins localization and evidences for nuclear active RAS2 involvement in invasive growth in saccharomyces cerevisiae". Doctoral thesis, Università degli Studi di Milano-Bicocca, 2013. http://hdl.handle.net/10281/41878.
Pełny tekst źródłaD'Silva, Nisha Jacinta. "Rap1, a small GTP-binding protein in the rat parotid gland : identification, investigation of function and regulation /". Thesis, Connect to this title online; UW restricted, 1997. http://hdl.handle.net/1773/6388.
Pełny tekst źródłaWahlström, Annika. "Defining RCE1 and ICMT as therapeutic targets in K-RAS-induced cancer /". Göteborg : The Wallenberg Laboratory, Dept.of Molecular and Clinical Medicine, Institute of Medicine at Sahlgrenska Academy, University of Gothenburg, 2009. http://hdl.handle.net/2077/19643.
Pełny tekst źródłaKatsoulotos, Gregory Peter St George Clinical School UNSW. "The function of the signaling protein Ras guanine releasing protein 4 (RasGRP4) in human mast cells". Awarded by:University of New South Wales. St George Clinical School, 2006. http://handle.unsw.edu.au/1959.4/27341.
Pełny tekst źródłaSelf, Annette Jane. "Structural and functional analysis of Ras and Ruo-related small GTP-binding proteins". Thesis, Institute of Cancer Research (University Of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266353.
Pełny tekst źródłaLemaire, Mathieu. "Intracellular signals underlying the inductive effects of agrin during neuromuscular junction formation : study on the roles of ras and Shc". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0030/MQ64388.pdf.
Pełny tekst źródłaBolourani, Parvin. "Partitioning of the response to cAMP via two specific Ras proteins during Dictyostelium discoideum development". Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/1719.
Pełny tekst źródłaJayakanth, Kankanala. "Design, synthesis and biological evaluation of inhibitors of FGFR, VEGFR-2 and Ras proteins". Thesis, University of Leeds, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.550818.
Pełny tekst źródłaKapoor, Shobhna [Verfasser], Roland [Akademischer Betreuer] Winter i Martin [Akademischer Betreuer] Engelhard. "Biophysical insights into the Ras-membrane ballet: orientational flexibility, conformational substates and mechanosensitivity of Ras proteins / Shobhna Kapoor. Betreuer: Roland Winter. Gutachter: Martin Engelhard". Dortmund : Universitätsbibliothek Dortmund, 2013. http://d-nb.info/1099297656/34.
Pełny tekst źródłaHo, Peter D. "Regulation of morphology and intracellular calcium by Ras in rat neonatal cardiac myocytes /". Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2000. http://wwwlib.umi.com/cr/ucsd/fullcit?p9984293.
Pełny tekst źródłaYasmin, Lubna. "Exoenzyme S of Pseudomonas aeruginosa : cellular targets and interaction with 14-3-3". Doctoral thesis, Umeå : Univ, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1411.
Pełny tekst źródłaBradbury, Andrew W. "Cyclic AMP binding proteins and ras p21 oncogene expression in human colorectal cancer and mucosa". Thesis, University of Edinburgh, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.531024.
Pełny tekst źródłaFalsetti, Samuel C. "The Role of RalA and RalB in Cancer". [Tampa, Fla] : University of South Florida, 2008. http://purl.fcla.edu/usf/dc/et/SFE0002307.
Pełny tekst źródłaOmholt, Katarina. "Activating proto-oncogene mutations in human cutaneous melanoma /". Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-191-1/.
Pełny tekst źródłaHoenerhoff, Mark James. "Bmi-1 collaborates with H-ras to promote mammary epithelial cell transformation, tumorigenesis, and metastasis". Diss., Connect to online resource - MSU authorized users, 2008.
Znajdź pełny tekst źródłaTitle from PDF t.p. (viewed on July 10, 2009) Includes bibliographical references (p. 157-174). Also issued in print.
Khan, Abdul Kareem. "Electrostaticanalisys the Ras active site". Doctoral thesis, Universitat Pompeu Fabra, 2009. http://hdl.handle.net/10803/7161.
Pełny tekst źródłaRas es una proteïna essencial de senyalització i actúa com un interruptor cel.lular. Les característiques estructurals de Ras en el seu estat actiu (ON) són diferents de les que té a l'estat inactiu (OFF). En aquesta tesi es duu a terme una anàlisi exhaustiva de l'estabilitat dels residus del centre actiu deRas en l'estat actiu i inactiu.
The electrostatic preorganization of the active site has been put forward as the general framework of action of enzymes. Thus, enzymes would position "strategic" residues in such a way to be prepared to catalyze reactions by
interacting in a stronger way with the transition state, in this way decreasing the activation energy g cat for the catalytic process. It has been proposed that
such electrostatic preorientation should be shown by analyzing the electrostatic stability of individual residues in the active site.
Ras protein is an essential signaling molecule and functions as a switch in the
cell. The structural features of the Ras protein in its active state (ON state) are different than those in its inactive state (OFF state). In this thesis, an exhaustive analysis of the stability of residues in the active and inactive Ras active site is performed.
Phan, Vernon Truong. "The Ras-GAP proteins Ira2 and neurofibromin are negatively regulated by ubiquitin-associated proteins Gpb1 in yeast and ETEA/UBXD8 in human cells". Diss., Search in ProQuest Dissertations & Theses. UC Only, 2008. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3297797.
Pełny tekst źródłaHuynh, Carl. "The cytoprotective role of Ras signaling in glomerular epithelial cell injury /". Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=112639.
Pełny tekst źródłaWinge, Per. "The evolution of small GTP binding proteins in cellular organisms. Studies of RAS GTPases in arabidopsis thaliana and the Ral GTPase from Drosophila melanogaster". Doctoral thesis, Norwegian University of Science and Technology, Faculty of Natural Sciences and Technology, 2002. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-169.
Pełny tekst źródłaSmall GTP binding proteins function as molecular switches which cycles between GTP-bound ON and GDP-bound OFF states, and regulate a wide variety of cellular processes as biological timers. The first characterized member of the small GTPase family, the mutated oncogene p21 src, later known as Harvey-Ras, was identified in the early 1980s (Shih, T. Y. et al. 1980). In the following years small Ras-lik GTPases were found in several organisms and it was soon discovered that they took part in processes, such as signal transduction, gene expression, cytoskeleton reorganisation, microtubule organisation, and vesicular and nuclear transport. The first Rho (Ras homology) gene was cloned in 1985 from the sea slug Aplysia (Madaule, P. et al. 1985) and because of their homology to Ras it was first suspected that they could act as oncogenes. Later studies have shown that even though they participate in processes such as cell migration and motility they are not mutated in cancers.
The first indications that Rho was a signaling protein regulating the actin cytoskeleton, came from experiments where activated forms of human RhoA was microinjected into 3T3 cells (Paterson, H. F. et al. 1990). Another Rho-like GTPase Rac1 (named after Ras-related C3 botulinum toxin substrate) was later shown to regulate actin cytoskeletal dynamics as well, suggesting that Rho-family members cooperate in controlling these processes (Ridley, A. J. et al. 1992). The Rac GTPase was also implicated in regulating the phagocytic NADPH oxidase, which produce superoxide for killing phagocytized microorganisms (Abo, A. et al. 1991). Thus, it soon became clear that Rac/Rho and the related GTPase Cdc42 (cell division cycle 42) had central functions in many important cellular processes.
There are at least three types of regulators for Rho-like proteins. The GDP/GTP exchange factors (GEFs) which stimulates conversion from the GDPbound form to the GTP-bound form. GDP dissociation inhibitors (GDIs) decrease the nucleotide dissociation from the GTPase and retrieve them from membranes to the cytosol. GTPase activating proteins (GAPs) stimulates the intrinsic GTPase activity and GTP hydrolysis. In addition there are probably regulators that dissociate GDI from the GTPase leaving it open for activation by the RhoGEFs.
Ras and Rho-family proteins participate in a coordinated regulation of cellular processes such as cell motility, cell growth and division. The Ral GTPase is closely related to Ras and recent studies have shown that this GTPase is involved in crosstalk between both Ras and Rho proteins (Feig, L. A. et al. 1996; Oshiro, T. et al. 2002). Ral proteins are not found in plants and they appear to be restricted to animalia and probably yeast. During a screen for small GTPases in Drosophila melanogaster I discovered in 1993 several new members of the Ras-family, such as Drosophila Ral (DRal), Ric1 and Rap2. The functions of Ral GTPases in Drosophila have until recently been poorly known, but in paper 2 we present some of the new findings.
Rho-like GTPases have been identified in several eukaryotic organisms such as, yeast (Bender, A. et al. 1989), Dictyostelium discoideum (Bush, J. et al. 1993), plants (Yang, Z. et al. 1993), Entamoeba histolytica (Lohia, A. et al. 1993) and Trypanosoma cruzi (Nepomuceno-Silva, J. L. et al. 2001). In our first publication, (Winge, P. et al. 1997), we describe the cloning of cDNAs from RAC-like GTPases in Arabidopsis thaliana and show mRNA expressions pattern for five of the genes. The five genes analyzed were expressed in most plant tissues with the exception of AtRAC2 (named Arac2 in the paper), which has an expression restricted to vascular tissues. We also discuss the evolution and development of RAC genes in plants. The third publication, (Winge, P. et al. 2000), describe the genetic structure and the genomic sequence of 11 RAC genes from Arabidopsis thaliana. As most genomic sequences of the AtRACs we analyzed came from the Landsberg erecta ecotype and the Arabidopsis thaliana genome was sequenced from the Columbia ecotype, it was possible to compare the sequences and identify new polymorphisms. The genomic location of the AtRAC genes plus the revelation of large genomic duplications provided additional information regarding the evolution of the gene family in plants. A summary and discussion of these new findings are presented together with a general study of small Ras-like GTPases and their evolution in cellular organisms. This study suggests that the small GTPases in eukaryots evolved from two bacterial ancestors, a Rab-like and a MglA/Arp-like (Arf-like) protein. The MglA proteins (after the mgl locus in Myxococcus xanthus) are required for gliding motility, which is a type of movement that take place without help of flagella.
The second publication describes experiments done with the Drosophila melanogaster DRal gene and its effects on cell shape and development. Ectopic expression of dominant negative forms of DRal reveals developmental defects in eye facets and hairs, while constitutive activated forms affects dorsal closure, leaving embryos with an open dorsal phenotype. Results presented in this publication suggest that DRal act through the Jun N-terminal kinase (JNK) pathway to regulate dorsal closure, but recent findings may point to additional explanations as well. The results also indicate a close association between processes regulated by Rac/Rho and Ral proteins in Drosophila.
Appleman, Victoria A. "Mechanisms of KRAS-Mediated Pancreatic Tumor Formation and Progression: A Dissertation". eScholarship@UMMS, 2012. https://escholarship.umassmed.edu/gsbs_diss/600.
Pełny tekst źródłaAdhikari, Anirban. "Regulation of guanine nucelotide exchange in inhibitory G protein alpha subunit by activator of G protein signaling 3 and novel regulatory peptides". Embargoed access until after 12/19/2006, 2005. http://www4.utsouthwestern.edu/library/ETD/etdDetails.cfm?etdID=114.
Pełny tekst źródłaPickford, Christopher. "Mechanism of nucleotide exchange by guanine nucleotide exchange factors on the Ras superfamily of small G-proteins". Thesis, University College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325813.
Pełny tekst źródłaKhanna, Ankita, Pouya Lotfi, Anita J. Chavan, Nieves M. Montaño, Parvin Bolourani, Gerald Weeks, Zhouxin Shen i in. "The small GTPases Ras and Rap1 bind to and control TORC2 activity". NATURE PUBLISHING GROUP, 2016. http://hdl.handle.net/10150/614747.
Pełny tekst źródłaEstrozi, Bruna. "Avaliação anatomoclínica e molecular do melanoma cutâneo em pacientes jovens (idade 18-30 anos)". Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/5/5144/tde-01042015-144721/.
Pełny tekst źródłaThe incidence of cutaneous melanoma in young adults has dramatically increased in recent years. However, there is scarce data about the clinicopathological and molecular characteristics on the melanomas occurring at this age group. The present study aimed to evaluate 132 patients aged between 18 and 30 years with primary cutaneous melanoma with emphasis on the study of clinical, histopathological characteristics and molecular evaluation of mutations in BRAF, NRAS and KIT genes. Regarding the clinical and histopathological findings, the following results were found: female predominance (61.4%), trunk was the most commonly anatomical site involved (44.3%) and superficial spreading melanoma, was the most common histological type (79.5 %). The V600E mutation in BRAF (BRAFV600E) gene was analyzed in 93 cases, using RT-PCR. It was present in 38.7% (36/93) and statistically related to the vertical growth phase (p = 0.01), mild inflammatory infiltration (p = 0.02) and the presence of intradermal mitosis (p = 0.004). There was, also, strongly evidence of an association with the presence of ulceration (p = 0.05). Worse prognosis was associated with these variables. There was a predominance of BRAFV600E mutation in anatomical regions related to intermittent sun exposure. No cases of melanoma with BRAFV600E mutation showed regression phenomenon (p < 0.05). There was no significant association between BRAFV600E and gender, histological type, Clark level, Breslow thickness, solar elastosis, angiolymphatic and perineural invasion, sattelitosis, coexisting melanocytic nevus and survival. The presence of a mutation in NRAS, by RT-PCR was seen in 3.95% (3/76) of the cases. All these three mutations were of type 61K, occurred in male patients and the head and neck region. BRAFV600E and NRAS mutations, when present, were mutually exclusive. The frequency of KIT mutations, analyzed by sequencing, was 11.1% (3/27). The three mutations identified in this gene were located in exon 9 (G510, G498S and 489I). Concomitant mutations were found between KIT and NRAS and BRAFV600E. Due to the small number of KIT and NRAS mutated cases, it was not possible to establish clinical and histopathological correlations and mutation status in these genes. This study was the first to describe the G510D and G498S mutations in KIT gene in cutaneous melanomas. In the present study, BRAFV600E mutation in cutaneous melanoma of young adults correlated with anatomic and clinical features of worse prognosis compared to wild type
Jeong, Sun Yong. "Functional investigation of arabidopsis long coiled-coil proteins and subcellular localization of plant rangap1". The Ohio State University, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=osu1086119855.
Pełny tekst źródłaMüller, Jasmin [Verfasser]. "Design of drugs for the inhibition of the cancer related proteins MIA, Rheb and K-Ras / Jasmin Müller". Wuppertal : Universitätsbibliothek Wuppertal, 2019. http://d-nb.info/1192844750/34.
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