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Melidonie, Jason, Junzhi Liu, Yubin Fu, Jan J. Weigand, Reinhard Berger i Xinliang Feng. "Pyrene-Fused s-Indacene". ACS Publications, 2018. https://tud.qucosa.de/id/qucosa%3A36576.
Pełny tekst źródłaMangnall, T. I. "Pyrene based Metal Organic Frameworks". Thesis, University of Liverpool, 2016. http://livrepository.liverpool.ac.uk/3000462/.
Pełny tekst źródłaLaunen, Loren A. "Pyrene biodegradation by Penicillium janthinellum SFU403". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0022/NQ51887.pdf.
Pełny tekst źródłaTEIXEIRA, SILVIO CESAR GODINHO. "PYRENE ADSORPTION IN BRAZILIAN SOILS STUDY". PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2008. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=12309@1.
Pełny tekst źródłaA maioria dos estudos envolvendo adsorção de hidrocarbonetos policíclicos aromáticos (HPA) é realizada em solos de regiões de clima frio. Como em países tropicais as características dos processos pedológicos e os solos resultantes são diferentes há necessidade desses estudos em solos brasileiros. Com esse objetivo, este trabalho estudou a adsorção de pireno em sete categorias representativas de solos brasileiros: Argissolo, Latossolo Amarelo, Latossolo Vermelho acriférrico, Latossolo Vermelho Amarelo distrófico, Neossolo Quartzarênico, Organossolo e Vertissolo. Foram realizados ensaios de adsorção usando massa de amostra dos solos de 2,5 g e 5,0 g. Para todas as categorias de solos estudados observou-se diferentes tempos de equilíbrio tanto nos estudos feitos com 2,5 g de solo quanto naqueles com 5,0 g. Nos experimentos realizados com a menor massa (2,5 g), observou-se que os perfis das curvas de adsorção para o Latossolo Vermelho acriférrico e para o Vertissolo apresentaram diferenças significativas sugerindo maiores competições pelos sítios de sorção. Para as demais categorias não foi observada diferença significativa no perfil das curvas de adsorção. Verificou-se ainda que não foi somente o teor de matéria orgânica responsável pelo equilíbrio do processo de adsorção como esperado. A presença de argilas expansivas pode ter contribuição para o aumento da quantidade de pireno adsorvida no solo (Q), como foi verificado para o Vertissolo. Foi observado que as categorias de solos estudadas apresentam características físico-químicas e Koc muito diferentes indicando que o processo de adsorção de pireno nestes solos não pode ser considerado como um modelo único. Neste trabalho o processo de adsorção de pireno foi descrito pelas isotermas de Langmuir (Argissolo e Latossolo Vermelho acriférrico), de Langmuir com linearização (Latossolo Vermelho Amarelo distrófico), de BET (Neossolo Quartzarênico) e isoterma linear (Vertissolo). Os resultados obtidos para o Latossolo Amarelo não se ajustam aos modelos de isotermas testados.
Since most of the studies that involve polycyclic aromatic hydrocarbons (PAH) adsorption in soils are make in regions of temperate or cold climate. In tropical countries, the characteristics of the pedological processes and the resultant soils are quite different there is the necessity of working on new studies in the Brazilian soils. In this dissertation, the pyrene adsorption in seven differents Brazilian soils was studied: Clays soils, Yellow Latosoil, Red Anionic Latosoil, Red Yellow Latosoil, Neosoil Quartzarenic, Organic soil and Vertisoil. Two groups of adsorption tests were carried out, in the first one we used samples of 2.5g of soil and in the second one the soil mass was increased to 5.0g. To all soils, it was possible to observe that, when the initial mass of soil was changed, different times of reaction were needed so that the sorption process could reach the thermodynamic equilibrium. And yet because of this bigger competition, the profile of the Red Anionic Latosoil and Vertisoil curves, obtained by the usage of different pyrene/soil relations, presented meaningful differences when compared. The presence of the swelling clays may contribute to the increase of the quantity of pyrene adsorpted in the soil (Q), such as happened in the Vertisoil. In this work, was found the Langmuir`s isotherms to Clays soils and Red Yellow Latosoil, BET to Neosoil Quartzarenic and linear isotherm to Vertisoil.
Karabaeva, Kanykey E. "Photochemistry of Masked Pyrene-4,5-Dione". Bowling Green State University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1371083757.
Pełny tekst źródłaCastle, Saffron Jane. "Sensing bilayer pressures with pyrene-labelled probes". Thesis, Imperial College London, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.281742.
Pełny tekst źródłaCarter, Tom Scott. "Synthetic lectins with pyrene at the core". Thesis, University of Bristol, 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.702443.
Pełny tekst źródłaFagla-Amoussou, Akouavi Balbine. "Etude des interactions polluants aromatiques polycycliques (HAP)-récepteurs adrénergiques-phospholipides membranaires dans le tissu adipeux". Thesis, Vandoeuvre-les-Nancy, INPL, 2010. http://www.theses.fr/2010INPL080N/document.
Pełny tekst źródłaObesity is a disease defined by an accumulation of fat in adipose tissue with adverse consequences for health. The causes of obesity are many.In recent work, there was demonstrated the role of environmental pollution in weight gain.In this work, the assumptions that the adrenergic receptors on the surface of fat cells would home to the accumulation of polycyclic aromatic pollutants have been verified by measurement of several agonists and antagonists specific and non-specific in the presence or absence of benzo[a]pyrene receptors on human cells and Chinese hamster (CHO). The amounts of cAMP obtained showed that PAHs are not deposited on β-receptors, β1, β2, β3 adrenergic receptors.This accumulation occurs at the cytoplasmic membrane phospholipids of the cells. What cau-ses stiffness of the membranes. This observation tends to reinforce the hypothesis that benzo [a]pyrene induce an inhibition of lipolysis by the accumulation in the phospholipid bilayer and conformational changes of the bilayer phospholipids in the vicinity of receptors seven transmembrane domains which are β-adrenergic receptors
Boateng, Stephen. "Photophysical properties of pyrene, 2,7 diazapyrene and 1,3-bis(β-naphthyl)propane". Thesis, University of North Texas, 2007. https://digital.library.unt.edu/ark:/67531/metadc3999/.
Pełny tekst źródłaChercka, Dennis [Verfasser]. "Pyrene derivatives as donors and acceptors / Dennis Chercka". Mainz : Universitätsbibliothek Mainz, 2015. http://d-nb.info/1069521256/34.
Pełny tekst źródłaBilash, О. М., О. М. Galaichenko, O. A. Sushko i M. M. Rozhitskii. "New nanophotonic detection method of benzo[a]pyrene". Thesis, КНУ імені Тараса Шевченка, 2011. http://openarchive.nure.ua/handle/document/8853.
Pełny tekst źródłaDe, Halleux Véronique. "Fluorescent discotic liquid crystalline materials based on pyrene". Doctoral thesis, Universite Libre de Bruxelles, 2002. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/211395.
Pełny tekst źródłaMaivaldová, Iva. "Interakce fosfolipidů s polyelektrolyty ve vodném prostředí". Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2010. http://www.nusl.cz/ntk/nusl-216675.
Pełny tekst źródłaBarboříková, Hana. "Směsné lipidy a jejich interakce s biopolymery". Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2017. http://www.nusl.cz/ntk/nusl-316157.
Pełny tekst źródłaSho, Michiei 1976. "Characterization of pyrene degradation by Mycobacterium sp. strain S65". Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=79125.
Pełny tekst źródłaPyrene catabolic genes in S65 were partially characterized by Southern hybridization using a probe constructed from the naphthalene inducible pyrene dioxygenase gene, nidA, from the pyrene-degrading bacterium, Mycobacterium sp. strain PYR-1.
Ross, Helen L. "The metabolism of benzo(a)pyrene in human cells". Thesis, University of Nottingham, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.253019.
Pełny tekst źródłaAlqurashy, Bakhet. "Pyrene based donor-acceptor conjugated polymers for photovoltaic applications". Thesis, University of Sheffield, 2017. http://etheses.whiterose.ac.uk/17244/.
Pełny tekst źródłaWeyand, Eric Henry. "The metabolic fate of benzo [a] pyrene in vivo". Diss., Virginia Polytechnic Institute and State University, 1986. http://hdl.handle.net/10919/77786.
Pełny tekst źródłaPh. D.
Zvaigzne, Anita Ilze. "Thermochemical investigations of crystalline solutes in non-electrolyte solutions: Mathematical representation of solubility data and the development of predictive solubility equations in systems with specific and non-specific interactions". Thesis, University of North Texas, 2008. https://digital.library.unt.edu/ark:/67531/metadc28369/.
Pełny tekst źródłaRamos, Chagas Gabriela. "Polymères électrodéposés nanostructurés : design et propriétés de films dérivés de monomères du thienothiophène et du pyrène". Thesis, Université Côte d'Azur (ComUE), 2017. http://www.theses.fr/2017AZUR4108/document.
Pełny tekst źródłaControlling surface hydrophobicity and water adhesion is a fundamental tool for various applications. Electropolymerization is a very versatile method that can be used to control these parameters and for the production of tunable nanostructured materials. Here, we show that by differentiating the polymerizable core (thienothiophene or pyrene), varied surface morphologies and wettabilities are produced by a direct electropolymerization process. Nanotubes and tree-like structures are obtained starting from thienothiophene derivatives without using any template. Depending on the electrodeposition method and parameters, different kinds of nanotubes are obtained. The electrochemical method and the grafted substituent play an important role on the surface structuration. The surfaces display different contact angles, but always with high water adhesion. On the other hand, pyrenes with various substituents are employed to produce hydrophobic/ superhydrophobic and fluorescent surfaces and, for the first time, with anti-bioadhesion and anti-biofilm properties. Copolymers of pyrenes were electrodeposited to yield surfaces with pH-responsivity and controllable water adhesion. A new method using a catapult system was implemented to measure the adhesive behavior of sticky and non-sticky surfaces. Thus, it has been shown the important role of the monomer core on the final properties of the surfaces opening new doors to explore this domain in the surface science field and applications
Shirdel, Javid. "Photo-physical characterization of flavin-pyrene-phenothiazine molecular photonic complexes". [S.l.] : [s.n.], 2007. http://deposit.ddb.de/cgi-bin/dokserv?idn=985128062.
Pełny tekst źródłaRIZEL, PATRICIA. "QUALITATIVE STUDIES FOR DETERMINATION OF PYRENE METABOLITES USING GC/MS". PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2003. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=4329@1.
Pełny tekst źródłaOs Hidrocarbonetos Policíclicos Aromáticos (HPAs) são contaminantes carcinogênicos e mutagênicos, freqüentemente encontrados no ambiente. Muitos organismos são capazes de metabolizá-los rapidamente, tornando de fundamental importância o desenvolvimento de técnicas analíticas para a determinação de seus metabólitos. A determinação do 1- hidroxipireno é considerada com uma das primeiras etapas para a avaliação do risco ambiental por exposição dos HPAs. O pireno é um dos compostos predominantes desta classe de xenobióticos e o 1-hidroxipireno é o seu principal metabólito. Neste estudo é apresentado uma método para análise qualitativa do 1-hidroxipireno. Testes foram realizados afim de viabilizar a aplicação de uma metodologia para análises de rotina em amostras biológicas. O método escolhido envolve uma etapa de hidrólise ácida com subsequente extração líquido-líquido para obtenção do 1- hidroxipireno. A cromatografia de permeação em gel (CPG) foi empregada como um método de separação de lipídios, seguida de uma etapa de cromatografia líquida de coluna aberta. Uma vez que o 1-hidroxipireno é um composto de baixa volatilidade, foi incluída uma etapa de derivação com BSTFA e seguida de análise por CG/EM.
Polycyclic Aromatic Hydrocarbons are ubiquitous pollutants that usually present carinogenic and mutagenic effects. Several organisms are able to metabolize them quickly, and therefore becoming very important the development of analytical techniques for their metabolites determination. The chemical analyses of 1-hydroxipyrene is one of the first steps for evaluation of environmental assessment by PAH exposure. Pyrene is one of the principal compounds of this xenobiotic class and 1-hydroxipyrene is yours major metabolite. This study presents a method for qualitative analysis of 1-hydroxipirene. Tests were performed due to allow the use of a methodology for routine analysis in biological samples. The chosen method included acid hydrolysis followed of liquid-liquid extraction to obtain 1- hydroxipyrene. Gel permeation chromatography (GPC) was applied as a lipid separation method, and then liquid chromatography of opened column. As long as the 1- hydroxipyrene is a low volatile compound, it was included one step of derivatization with BSTFA followed by gas chromatography/mass spectrometer (GC/MS) analysis.
Yang, Yang. "The in vivo metabolism of benzo[a]pyrene studied by chromatography in combination with mass spectrometry /". Stockholm, 1997. http://diss.kib.ki.se/1997/91-628-2640-9/.
Pełny tekst źródłaSouleymanou, Myriam. "Pyrene-tagged Ligands as a Bridge between Homogeneous and Heterogeneous Catalysis". Doctoral thesis, Universitat Rovira i Virgili, 2019. http://hdl.handle.net/10803/668974.
Pełny tekst źródłaLa presente tesis trata sobre el desarrollo de catalizadores homogéneos que contienen fragmentos poliaromáticos que se han introducido con el objetivo de facilitar el anclaje en soportes sólidos para conseguir la fácil separación y el reciclaje del catalizador. Se eligieron grupos pireno, ya que es conocido que promueve interacciones aromáticas fuertes pi-pi por apilamiento en superficies de carbono. En consecuencia, el trabajo se ha centrado en los soportes de carbono (nanotubos de carbono, óxido de grafeno reducido y perlas de carbono) como materiales para esta estrategia de anclaje no covalente en soportes sólidos. Además, se ha explorado un sistema catalítico bifásico como otra estrategia para el reciclaje y la reutilización de catalizadores homogéneos. Este sistema catalítico bifásico, que consiste en líquidos iónicos (IL) y dióxido de carbono supercrítico (scCO2), se usa en la reacción de telomerización de 1,3-bytadieno con dióxido de carbono para producir ä-lactona en un flujo continuo.
The present thesis deals with the development of established homogeneous catalysts bearing polyaromatic fragments that would facilitate catalyst separation and recycling. Pyrene tags were chosen as it is a well-known antenna that promotes strong aromatic pi-pi stacking interactions onto carbon surfaces. Consequently, we focused our attention on carbon supports (carbon nanotubes, reduced graphene oxide and carbon beads) as solid supports for this noncovalent anchoring strategy on solid supports. In addition, a biphasic catalytic system as another strategy for the recycling and reuse of homogeneous catalysts is explored. This biphasic catalytic system consisting of ionic liquids (ILs) and supercritical carbon dioxide (scCO2) was used in the Pd-catalyzed telomerization reaction of 1,3-butadiene with carbon dioxide to yield ä-lactone in a continuous flow-manner.
Stylianou, Kyriakos C. "Biologically derived and pyrene-based metal-organic frameworks for advanced applications". Thesis, University of Liverpool, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.569888.
Pełny tekst źródłaWang, Yixi, i 王义熙. "Exposure to benzo[a]pyrene and breast cancer : a systematic review". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/206972.
Pełny tekst źródłapublished_or_final_version
Public Health
Master
Master of Public Health
Lawrence, Deirdre Michelle. "DNA adducts as molecular biomarkers of exposure to benzo(a)pyrene". Thesis, Massachusetts Institute of Technology, 1997. http://hdl.handle.net/1721.1/42792.
Pełny tekst źródłaGu, Jie. "Effects of benzo[a]pyrene on the biological function of eosinophils". HKBU Institutional Repository, 2011. http://repository.hkbu.edu.hk/etd_ra/1279.
Pełny tekst źródłaBoateng, Stephen Omary Mohammad A. "Photophysical properties of pyrene, 2, 7 diazapyrene and 1, 3-bis ([beta] naphthyl) propane". [Denton, Tex.] : University of North Texas, 2007. http://digital.library.unt.edu/permalink/meta-dc-3999.
Pełny tekst źródłaHurk, Peter van den. "Interactive effects of cadmium and benzo(a)pyrene in mummichog (Fundulus heteroclitus)". W&M ScholarWorks, 1998. https://scholarworks.wm.edu/etd/1539616705.
Pełny tekst źródłavan, den Hurk Peter. "Interactive effects of cadmium and benzo(a)pyrene in mummichog (Fundulus heteroclitus)". W&M ScholarWorks, 1998. https://scholarworks.wm.edu/etd/1539616888.
Pełny tekst źródłaHolínková, Petra. "Pokročilé fluorescenční techniky ve výzkumu micelárních systémů a jejich interakcí s biopolymery". Doctoral thesis, Vysoké učení technické v Brně. Fakulta chemická, 2019. http://www.nusl.cz/ntk/nusl-402106.
Pełny tekst źródłaVenerová, Tereza. "Interakce a agregace v systémech hyaluronan-aminokyseliny-tenzid". Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2009. http://www.nusl.cz/ntk/nusl-216525.
Pełny tekst źródłaNordling, Mirjam. "Characterization of toxicological effects of a novel in vivo benzo[a]pyrene metabolite in colonic cells /". Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-034-6/.
Pełny tekst źródłaLe, Thi Nhi Cong, Thi Ngoc Mai Cung, Thi Thanh Vu, Ngoc Minh Nghiem, Phuong Ha Hoang, Thi Lien Do i Thi To Uyen Do. "Pyrene degradation of biofilm-forming Paracoccus sp. DG25 isolated from oil polluted samples collected in petroleum storage Duc Giang, Hanoi". Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-190617.
Pełny tekst źródłaTrong nghiên cứu này, từ các mẫu đất và nước nhiễm dầu lấy tại kho xăng Đức Giang, Hà Nội, chúng tôi đã phân lập được chủng vi khuẩn có khả năng tạo màng sinh học tốt. Chủng vi khuẩn này đã được phân loại và định tên là Paracoccus sp. DG25 với số đăng ký trên ngân hàng Gen là KJ608354. Chúng tôi cũng đã nghiên cứu một số điều kiện hóa lý ảnh hưởng tới khả năng hình thành màng sinh học như pH, nhiệt độ, nguồn Carbon và nguồn Nitơ. Kết quả cho thấy, chủng DG25 có khả năng tạo màng tốt nhất ở các điều kiện pH 7, 37 oC, nguồn Carbon là maltose và nguồn Nitơ là KNO3. Sử dụng các điều kiện tối ưu này để tạo màng và đánh giá khả năng phân hủy pyrene của màng tạo thành. Bằng phương pháp sắc ký lỏng cao áp, chúng tôi đã đánh giá được hàm lượng pyrene bị phân hủy sau 7 ngày nuôi tĩnh bởi màng sinh học của chủng DG25 lên tới 76,07 % với nồng độ ban đầu là 300 ppm. Cho tới nay, chưa có nhiều công bố về hiệu quả phân hủy pyrene của các chủng vi khuẩn tạo màng sinh học. Do vậy, kết quả đạt được này mở ra khả năng sử dụng màng tạo thành bởi chủng DG25 để nâng cao hiệu quả phân hủy pyren và có thể mở ra phương pháp mới nhằm xử lý các hợp chất hydrocarbon thơm có trong nước ô nhiễm dầu ở Việt Nam
Ayoub, Pierre. "Molecular dynamics study of pyrene excimer formation and oxidation in lipid bilayer models". Thesis, Strasbourg, 2015. http://www.theses.fr/2015STRAE038/document.
Pełny tekst źródłaWe propose a novel approach to extract the lateral diffusion coefficient in lipid bilayers using excimer formation. In contrast to previous statistical models that modeled the system as points undergoing jumps from site to site on a lattice, we use coarse-grained molecular dynamics to study lipid bilayers simulated using the Martini force field. We derive time dependent reaction rates from survival probabilities obtained a posteriori from numerically generated trajectories of symmetric DOPC (1,2-Dioleoyl-sn-glycero-3-phosphocholine) and POPC (1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine) bilayers at 283K and 293K respectively. Collision dynamics are determined by virtually relabeling the simulated molecules. The fluorescent probes are assumed to behave like ordinary membrane lipids and therefore the dynamics remain unaffected. We derive a generalized expression for the survival probability combining independent pairs and size scaling assumptions, but no assumption is made regarding the kinetic rate of the excimer formation process. By fitting the numerically determined normalized fluorescence emission intensities to experimental titration curves, we obtain two sets of results for the lateral diffusion coefficients depending whether interleaflet excimer association is allowed or not. We use a capture radius of 0.5 nm, the distance at which the probes react to form excimers. By relating Martini dynamics to real fluorescence experiments, we estimate the numerical Martini acceleration factor. We also study mixtures of oxidized-non oxidized DOPC and POPC bilayers using a hydroperoxidized model of these lipids for different concentrations of the oxidized component (3.1%, 25% and 50%). Using pair correlation functions, we extract structural information on the systems and determine whether the two components are prone to mixing or not. Finally, we calculate the thermodynamic mixing parameters within the framework of the virial expansion
Zöphel, Lukas Julian [Verfasser]. "Chemical transformations of the pyrene K-region for functional materials / Lukas Julian Zöphel". Mainz : Universitätsbibliothek Mainz, 2012. http://d-nb.info/1026397146/34.
Pełny tekst źródłaCrawford, Andrew. "Catalytic borylation of C-H bonds : a route to photophysically interesting pyrene derivatives". Thesis, Durham University, 2011. http://etheses.dur.ac.uk/663/.
Pełny tekst źródłaBilash, О. М., О. М. Galaichenko, O. A. Sushko i M. M. Rozhitskii. "Benzo[a]pyrene its influence on human organism and new nanophotonic detection method". Thesis, Benzo[a]pyrene its influence on human organism and new nanophotonic detection method, 2011. http://openarchive.nure.ua/handle/document/8860.
Pełny tekst źródłaPoon, Po Ying. "The cyto-protective effect of ginsenosides towards benzo[a]pyrene : induced-DNA damage". HKBU Institutional Repository, 2010. http://repository.hkbu.edu.hk/etd_ra/1231.
Pełny tekst źródłaÖzbal, Can Cemil 1971. "Quantification of benzo[a]pyrene-diol-epoxide adducts by laser-induced fluorescence spectroscopy". Thesis, Massachusetts Institute of Technology, 1999. http://hdl.handle.net/1721.1/9513.
Pełny tekst źródłaIncludes bibliographical references.
Quantification of adducts in human samples is a challenging task in analytical chemistry. Humans are typically exposed to low levels of a wide range of different carcinogens. As a result, adduct quantification requires both a highly sensitive and a highly selective method. This project has focused on the development of new laser-induced fluorescence (LIF) based methods for the quantification of adducts in human samples. Two new instruments were built for LIF analysis. A cryogenic LIF instrument using a pulsed tunable dye laser as the excitation source was developed to obtain low temperature fluorescence emission spectra. A second instrument using a LIF detector interfaced to a HPLC separation system was developed to provide a higher level of selectivity than the cryogenic LIF system. The LIF instruments were used to quantify adducts of benzo[a]pyrene-7,8-diol-9,10- epoxide (BPDE) in human lung tissue and human bronchial epithelial cell histones and DNA and in human serum albumin. The presence of BPDE adducts in human lung tissue and human bronchial epithelial cell histones and DNA was proven by cryogenic fluorescence line-narrowing (FLN) spectroscopy. (-)-anti-BPDE-serum albumin adducts were quantified by HPLC-LIF in plasma obtained from 63 healthy volunteers. The method was shown to have a coefficient of variability of 22% and a detection limit of 20 attomoles of BPDE adduct. Adducts were detected in 60 of 63 samples (95%) at an average level of 0.22 femtomoles of adduct per mg of albumin. The investigation of histones as possible long-term molecular dosimeters was another focus in this research. The close proximity of histones and DNA coupled with the lack of repair and long lifetime make histones very attractive candidates as molecular dosimeters. The kinetics of histone turnover can most likely be accurately modeled by cellular turnover rates in vivo. Histone adducts were detected in human lung tissue and human bronchial epithelial cells. Histones were also shown to form adducts with BPDE, aflatoxin B1 (AFB,) and nitrosomethylurea (NMU) in TK6 cells grown in vitro. Histone adducts of AFB 1 , NMU, and BPDE were shown to be stable over 5 cell divisions.
by Can Cemil Özbal.
Ph.D.
Kučerová, Petra. "Přenos energie ve studiu hydrofobních domén koloidních systémů". Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2009. http://www.nusl.cz/ntk/nusl-216523.
Pełny tekst źródłaNeesu, Rachana. "Fused Arene-Based Molecular Systems as Additives for Organic Photovoltaics". TopSCHOLAR®, 2015. http://digitalcommons.wku.edu/theses/1471.
Pełny tekst źródłaBaldi, Leonardo Dela Coleta. "Avaliação da polaridade superficial de nailons por espectroscopia de fluorescencia". [s.n.], 2004. http://repositorio.unicamp.br/jspui/handle/REPOSIP/249452.
Pełny tekst źródłaDissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Quimica
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Mestrado
Físico-Química
Mestre em Química
Serpi, R. (Raisa). "Mechanism of benzo(a)pyrene-induced accumulation of p53 tumour suppressor protein in mouse". Doctoral thesis, University of Oulu, 2003. http://urn.fi/urn:isbn:9514270398.
Pełny tekst źródłaCosta, Telma Sofia Martins. "Photophysics of macromolecular pyrene-containing systems". Doctoral thesis, 2009. http://hdl.handle.net/10316/9622.
Pełny tekst źródłaSu, Chun Hsien, i 蘇俊憲. "Pyrene Based Initiator in Photo-induced ATRP and Persistently Enhanced Fluorescence Observed from Poly(styrene) with Pyrene Chromophore". Thesis, 2015. http://ndltd.ncl.edu.tw/handle/01861654838819565291.
Pełny tekst źródła國立清華大學
化學系
103
Chromophoric initiator containing pyrene moiety was synthesized and was used to the normal and photo-induced ATRP of various monomers to obtain the flourscent polymer. These well-controlled dye-labeled polymer showed a low polydispersity (Mw / Mn = 1.20 ~ 1.30), and could form the diblock copolymers. Photo-induced or Photo-mediated ATRP was performed in our study. Photo-induced ATRP is an efficient or economical method for methyl acrylate, methyl methacrylate and styrene polymerization. The photo-mediated polymerization could use the handheld UV light as the low energy source to replace the traditional oil bath or the high temperature condition. Besides, during the photo-induced ATRP process we found the poly(styrene) had the strongest fluorescence than other polymers. For this reason, we compared the fluorescence of dye-labeled polymer by ATRP and photo-induced ATRP. Moreover we designed some control experiments to illustrate and explain the strongly fluorescent effect in poly(styrene) by photo-induced ATRP. Meanwhile, we used the homo or diblock copolymer with chromophore to form the nanotube polymer structure by AAO (anodic aluminum oxide) template. The nanotube structure could be observed by the SEM (Scanning electron microscopy) and the fluorescence of nanotube polymer structure was also discussed.
Hsieh, Yun-chu, i 謝雲竹. "Phytoremediation of PAHs(pyrene) Contaminated Soils through mangroves". Thesis, 2008. http://ndltd.ncl.edu.tw/handle/q2ep2f.
Pełny tekst źródła國立中山大學
海洋環境及工程學系研究所
96
In this study,we used mangrove phytoremediation ecotechniques to treat polycyclic aromtic hydrocarbons (pyrene) contaminated soil. First, we compared the four species of mangroves in Taiwan, Kandelia candel Druce, Rhizophora stylosa Griff, Avicennia marina Vierh and Lumnitzera racemosa Willd, inoculated by endomycorrhizae in no contaminated soils. According to the experimental results, the four species of mangroves could be colonized by Glomus aggregatum and Glomus mosseae. In colonization rate and colonization intensity, Glomus aggregatum were found higher than those of Glomus mosseae. For the degradation efficiencies of pyrene in soils, according to the experimental results, we found that the Lumnitzera racemosa Willd exhibited best growing conditions among the four species. The degradation rates for all tests systems pyrene were measured above 90% . In accordance with passed study, the species of Kandelia candel Druce presented effective efficiencics for pyrene degradation. The speacis of Lumnitzera racemosa Willd and Kandelia candel Druce were planted in the artifical pyrene contaminated soils, which were incubated in a greenhouse , while the control systems without vegetation were used for comparison. After 90 days of incubation, the experimental result showed that the soils planted with Lumnitzera racemosa Willd and Kandelia candel Druce were found able to enhance the microbial and dehydrogenase activities. The addition of Glomus aggregatum could help plants to prevent from the stress of pyrene. The addition of salinity into the siols was a pressure for mangroves so the mangroves, incoculated by endomycorrhizae showed stronger dependence on mycorrhizal fungi than those in the siols of no salinity. In salty siol, mangroves exhibited high effective degradation rates for pyrene. In the siols for the illumination groups, the pyrene degradation rates for all test systems were measured about 85%. The siols for the dark groups showed that the average pyrene degradation rates were about 70%.
Chang, Yi Chih, i 張益銍. "Molecular Mechanism Studies of Benzo(a)pyrene Carcinogenesis". Thesis, 1999. http://ndltd.ncl.edu.tw/handle/35098957245627872584.
Pełny tekst źródła國立陽明大學
醫學生物技術研究所
87
Abstract Benzo(a)pyrene( B(a)P ) is a kind of environmental pollutants that commonly exists in our circumstance. It has been shown that B(a)P is carcinogenic in many researches of genotoxicities and experimental animals , but the underlying mechanism is still not clear. To surmise the possible molecular mechanisms, we studied the effects of B(a)P on the molecules in cytoplasm ( protein kinase C ) and nucleus ( proto-oncogene : c-jun , c-fos ) , individually , and B(a)P's transformation ability by performing doubling time , saturation density , transformation assays. From the doubling time and saturation density tests , we found that the cells doubling time was shortened and its saturation density was increased when the cells were treated with B(a)P (1-5 uM). Combined treatment of both B(a)P and the well known tumor promotor 12-o-tetradecanoyl phorbol 13-acetate (TPA) enhanced these observed phenomena. In cell transformation test , we observed that treatment of B(a)P alone transformed cells to foci formation. Its transformation ability was not as good as the well-known carrcinogen N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) , but better than TPA. If B(a)P was combined with TPA , the transformation ability was similar to positive control (MNNG+TPA). These results suggested that B(a)P could play a role as an initiator but not promotor during cell transformation. Protein kinase C (PKC) is pivotal in intracellular signal transduction, Therefore we analyzed B(a)P's effect on PKC translocation. From western blot results , B(a)P did not affect PKC-αandδisoform translocation. As we known , c-Jun and c-Fos are proteins that accelerate the processing of cell cycle. From northern blot analysis , B(a)P did not have significant effect on c-jun and c-fos expression. In summary , our data suggest that B(a)P may alter some events related to cell growth but not via PKC signal transduction and c-jun and c-fos expression. During carcinogenesis , B(a)P causes cell transformation and may play a role as an initiator.
Hu, Hsiao-Yun, i 胡曉雲. "Studies on the Phytoremediation of Pyrene Contaminated Soils". Thesis, 2008. http://ndltd.ncl.edu.tw/handle/52927547311263973055.
Pełny tekst źródła朝陽科技大學
環境工程與管理系碩士班
96
Polycyclic Aromatic the Hydrocarbons contamination concern has received takes seriously, PAHs was confirmed that surpasses several hundred derivatives has the carcinogenicity and causes the sudden change. At present improvement of processing PAHs often transforms into regarding the soil in the extract way, but transforms into the method to be able only to each interaction transformation, Following still needed - step by other technical processing, moreover also possibly destroys the local ecology resources. In recent years studied the discovery use plant cicada chrysalis to be possible in-situ repair soil of the organic matter pollution. In this study, as supply take alluvial soils and red soils was used for experiment which are the main category soil for farming in Taiwan, the quartz sand take the control group, and Pyrene was spiked into soils to simulate the contaminated soils, the use pot experiment planter Bermuda grass and Medicago sativa. Pyrene of contaminated soil in the different density, increases 5% raise earth separately, the test Bermuda grass and Medicago sativa to the soil in degeneration of effect the Pyrene. The result showed that increases 5% raise earth in the Pyrene density is 100 mg kg-1,200 mg kg-1,300 mg kg-1,400 mg kg-1, of contaminated quartz sand in 500 mg kg-1, the Medicago sativa to the Pyrene degeneration rate respectively is 73.3%, 58.1%, 49.7%, 37.7%, 30.6%. But increases 5% raise earth in the Pyrene density is 50 mg kg-1,100 mg kg-1,150 mg kg-1, of contaminated quartz sand in 200 mg kg-1 the Pyrene degeneration rate respectively is 74.7%, 65.7%, 57.2%, 51.7%. The result showed that contaminated quartz sand in 50 mg kg-1, the Medicago sativa to the Pyrene degeneration rate respectively is 74.7%, Therefore if the suggestion plants by the Bermuda grass and Medicago sativa lives cicada chrysalis processing the Pyrene contaminated soil, its soil increases 5% raise earth to be possible to promote degeneration of effect effectively the pollutant.