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Ostache, Nicu-Carmin. "Synthèse et fonctionnalisation de bicycles 5-5 polyazotés : pyrazolo[3,4-d]thiazoles et pyrazolo[3,4-c]pyrazoles". Thesis, Orléans, 2019. http://intranet.univ-orleans.fr/bibliotheques/theses/nicu-cosmin-ostache_3378_vm.pdf/.
Pełny tekst źródłaNitrogen-rich fused bicyclic structures are undisputedly one of the most used scaffolds for therapeutic use.The 5:5 polynitrogenated bicycles are moieties considerably less documented then their 6:6 or 6:5analogues. Despite the pharmacological potential of the pyrazolo[3,4-d]thiazoles and of thepyrazolo[3,4-c]pyrazoles, two examples of such rare families, only few methods of preparation and directfunctionalization of these heterocyclic moieties have been described.In this context, the main goal of our research aims at exploring new routes towards these bicyclic systemsfrom readily available and affordable starting materials. Efficient strategies were developed relying onhydrazine condensations, on intramolecular N-cyclizations, on chemo-selective halogenation and variouscross-coupling reactions. Moreover, the pyrazolo[3,4-d]thiazole entity was fused to a triazapentalenestructure in order to assess the spectroscopic properties
Gormen, Meral. "Synthesis Of Ferrocenyl Substituted Pyrazoles". Master's thesis, METU, 2005. http://etd.lib.metu.edu.tr/upload/3/12606358/index.pdf.
Pełny tekst źródłaEl, Youssoufi Jawad. "Synthèses de pyrazoles benzocyclohepténiques glycosylés". Limoges, 1997. http://www.theses.fr/1997LIMO0027.
Pełny tekst źródłaErvithayasuporn, Vuthichai. "Synthesis and photochemistry of pyrano[2,3-c]pyrazoles". Link to electronic thesis, 2006. http://www.wpi.edu/Pubs/ETD/Available/etd-042006-160619/.
Pełny tekst źródłaERVITHAYASUPORN, VUTHICHAI. "Synthesis and Photochemistry of Pyrano[2,3-c]pyrazoles". Digital WPI, 2006. https://digitalcommons.wpi.edu/etd-theses/228.
Pełny tekst źródłaDesalegn, Nebiyou. "Kinetic Studies Of The Thermolysis Of 3-Halogenated-4,5-Dihydro-3h-Pyrazoles". Digital Archive @ GSU, 2005. http://digitalarchive.gsu.edu/chemistry_theses/1.
Pełny tekst źródłaCooper, David Arthur. "The synthesis and characterization of some molybdenum, rhenium and rhodium complexes incorporating pyrazolylgallate ligands". Thesis, University of British Columbia, 1985. http://hdl.handle.net/2429/24597.
Pełny tekst źródłaScience, Faculty of
Chemistry, Department of
Graduate
Nakhai, Azadeh. "Synthetic studies of nitrogen containing heterocycles, particularly pyrazole and benzotriazine derivatives". Stockholm, 2009. http://diss.kib.ki.se/2009/978-91-7409-687-3/.
Pełny tekst źródłaDemirci, Deniz. "Synthesis Of 4-phenylselenyl-1h-pyrazoles By Electrophilic Cyclization". Master's thesis, METU, 2011. http://etd.lib.metu.edu.tr/upload/12613910/index.pdf.
Pełny tekst źródłaTruong, Phong Minh. "Hexa-aryl/alkylsubstituted Cyclopropanes". Digital Archive @ GSU, 2006. http://digitalarchive.gsu.edu/chemistry_theses/2.
Pełny tekst źródłaCottineau, Bertrand. "Contribution à l'étude du 3-hydroxy-1H-pyrazole-4-carboxylate d'éthyle : application à la synthèse de composés antidiabétiques". Orléans, 2002. http://www.theses.fr/2002ORLE2014.
Pełny tekst źródłaDIB/, DIB-OUADAH LATIFA. "Analyse structurale de pyrazoles : rmn, etude conformationnelle et distribution electronique". Paris 7, 1993. http://www.theses.fr/1993PA077144.
Pełny tekst źródłaFoster, Robert Stephen. "Expanding the functionalisation of sydnones : developing flexible routes to pyrazoles". Thesis, University of Sheffield, 2013. http://etheses.whiterose.ac.uk/3681/.
Pełny tekst źródłaTran, Gaël. "Synthèse de phosphonylpyrazoles et de fluoropyridazines". Thesis, Paris 6, 2015. http://www.theses.fr/2015PA066414/document.
Pełny tekst źródłaThe work presented in this manuscript concerns the development of synthetic routes to two families of heterocycles, namely phosphonylpyrazoles and fluoropyridazines. Phosphonylpyrazoles were synthesized using a Hirao-type cross-coupling, and it was demonstrated during this study that a single catalytic system based on Pd(OAc)2/XantPhos could perform the cross-coupling between a wide range of halopyrazoles and H-phosphonyls. Significant limits have been met in the scope of this method, especially regarding the substitution pattern of the halopyrazole. Nevertheless, at this time, this method is arguably one of the most flexible ways to synthesize phosphonylpyrazoles. Fluoropyridazines were synthesized using a [2+1]/[3+2] cycloaddition sequence between alkynes, the difluorocarbene :CF2, and alkyl diazoacetates. It was demonstrated during this study that a wide range of alkynes could be involved in this sequence, and that the corresponding 5-fluoropyridazines could be easily diversified
Hervé, Grégoire. "Progrès récents dans la chimie des molécules énergétiques : accès à de nouveaux hétérocycles azotés aromatiques très performants". Aix-Marseille 3, 2009. http://www.theses.fr/2009AIX30031.
Pełny tekst źródłaThe purpose of this thesis work was to design and to prepare new stable, highly-energetic and insensitive (or low-sensitive at least) explosives by the means of economical and industrial synthetic pathways. The synthesis of certain aromatic energetic compounds prepared in this framework affords significant enhancement in terms of energetic and physical properties ensuring ease of utilization and handling of such new materials in respect with high energetic performance. Several explosives exhibit unprecedented properties and offer a remarkable performance/sensitivity balance. A novel fully C-nitrated aromatic explosive is presented here and has, by far, the most important thermal and chemical stability in these series versus all the known nitrocarbons (i. E. Hexanitrobenzene) and nitroazoles
Chappuit, Lucrezia. "Design, synthèse et évaluation biochimique d’inhibiteurs des ADN Méthyltransférases". Thesis, Sorbonne université, 2018. http://www.theses.fr/2018SORUS372.
Pełny tekst źródłaThis manuscript presents the development of novel DNMT1 (DNA Methyltransferase) inhibi- tors. This enzyme is involved in epigenetic modification of DNA and its deregulation may lead to epigenetic cancers. The first part of this work focused on the design by molecular modeling of new prolino-homo-tryptophan compounds which can interact with both pockets of DNMT1. In a second time, molecular modeling allows us to design several pyrazole compounds as po- tential new DNMT1 inhibitors. Following these studies, all designed compounds were synthe- tized and tested on a recombinant human DNMT1enzyme thanks to a biochemical inhibition test. Biological evaluation bright to light two lead compounds which totally inhibit DNMT1 at high concentration (500 μM)
Oleksik, Laurence. "Methodology for the synthesis of 4 or 5-substituted-3-perfluoroalkyl pyrazoles". Thesis, University of Leicester, 2004. http://hdl.handle.net/2381/30087.
Pełny tekst źródłaDuprez, Virginie. "Synthèse des hydroxyalkyl pyrazoles, leurs complexes de titane et application en polymérisation". Aix-Marseille 3, 2002. http://www.theses.fr/2002AIX30007.
Pełny tekst źródłaDuring this project consisting in the development of new post metallocene catalytic systems, we fixed us the following three objectives : the syntheses of new ligands, preparation of titanium complexes and polymerisation reactions. The first part describes the syntheses of several hydroxyalkyl pyrazoles families, easily access with the pyrazole nucleus in which one nitrogen is substituted with an hydroxy alkyl side chain. These heteroatomics ligands are synthesised via alkylation reaction, epoxide ring opening or direct condensation of b diketones with hydrazine derivatives. The second part deals with the study of coordination modes of the different ligands with Ti, the syntheses of Ti(IV) complexes and their characterisation. Finally, the application of these Ti complexes as polymerisation catalysts with alkenes revealed an interesting activity. Several of the single site catalysts are able to convert ethylene in high molecular weight polyethylene
Paradis, Delphine. "Méthode d'analyse dans le miel de trois familles d'insecticides (nicotinoïdes, pyréthrinoïdes et pyrazoles) par chromatographies en phase gazeuse et en phase liquide couplées à la spectrométrie de masse en tandem. : application à l' étude de contamination de ruches". Thesis, Aix-Marseille, 2012. http://www.theses.fr/2012AIXM4058.
Pełny tekst źródłaSeveral extraction and analytical techniques existing to study insecticides in honey do not always allow reaching low limits of detection. However, to evaluate the toxicity of pesticides, values of limits of detection have to be close to 1 ng/g. The aim of this work was to develop extraction and analytical methods compatible with various types of honey (nectars and honeydews, monofloral and multifloral) and allowing to look for 25 insecticides belonging to 3 families (nicotinoids, pyrethroids and pyrazoles), with the lowest possible limits of detection and eliminating the maximum interference due to the matrix. After comparison of different extraction methods, the reserved technique is based on the QuEChERS EN 15662 method, which consists of an extraction and a purification with mixtures of salts adapted to the matrix and to the compounds to be extracted. Analysis were then performed using gas chromatography coupled with tandem mass spectrometry (GC-MS²) for the pyrazoles and the pyrethroids, and using high performance liquid chromatography coupled with tandem mass spectrometry (LC-MS²) for the nicotinoids and one pyrazole. Device settings have to be optimized to obtain a very low limit of detection. The mean extraction yields were typically between 60 and 140%. The methods are specific for tested honeys. These methods are applicable to analyze commercial honeys and allow reaching limits of detection between 0.2 and 0.7 ng/g. In practice, the dosage of these 3 families in different types of honeys, at low concentrations can be made in routine in an analysis laboratory
Poulsen, Sally-Ann, i n/a. "Pyrazolo(3,4-d)pyrimidines: Synthesis and Structure-Activity Relationships for Binding to Adenosine Receptors". Griffith University. School of Science, 1996. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20050901.161632.
Pełny tekst źródłaGrimes-Marchan, Thomas V. Cundari Thomas R. "Quantum perspectives on physical and inorganic chemistry". [Denton, Tex.] : University of North Texas, 2007. http://digital.library.unt.edu/permalink/meta-dc-5172.
Pełny tekst źródłaToto, Patrick. "Contribution à l'étude du 1H-pyrazole-4-carboxylate d'éthyle et de ses dérivés : application à la synthèse de nouveaux hétérocycles polycondensés". Orléans, 2004. http://www.theses.fr/2004ORLE2001.
Pełny tekst źródłaPoulsen, Sally-Ann. "Pyrazolo(3,4-d)pyrimidines: Synthesis and Structure-Activity Relationships for Binding to Adenosine Receptors". Thesis, Griffith University, 1996. http://hdl.handle.net/10072/365893.
Pełny tekst źródłaThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Science
Science, Environment, Engineering and Technology
Full Text
Karabiyikoglu, Sedef. "Synthesis Of Ferrocenyl Substituted Pyrazoles By Sonogashira And Suzuki-miyaura Cross-coupling Reactions". Master's thesis, METU, 2010. http://etd.lib.metu.edu.tr/upload/3/12612139/index.pdf.
Pełny tekst źródłaKarahan, Dag Fulya. "Synthesis Of 5-ferrocenyl-4-((4-nitrophenyl)sulfenyl)-1h-pyrazoles By Electrophilic Cyclization". Master's thesis, METU, 2011. http://etd.lib.metu.edu.tr/upload/12613443/index.pdf.
Pełny tekst źródłaMoukhliss, Maâti. "Synthèse de pyrazoles chiraux à squelette pinanique et cycloisomérisation catalytique de diènes-1,6". Aix-Marseille 3, 2001. http://www.theses.fr/2001AIX30029.
Pełny tekst źródłaThe aim of this thesis is the study of the enantioselective cycloisomerisation of 1,6-dienes by cationic and neutral palladium catalysts. A first, we prepared a series of new chiral nitrogen centred ligands, essentially, annelated pyrazoles from the " chiral pool ". These composed are obtained by condensation of chiral diketones with the hydrazine. A new synthetic way, in a " one-pot " sequence was finalised. It consists in condensing, under basic conditions, a conjugated enal or enone with the hydrazine substituted with a tosyle group. Subsequently, the alkylation of the chiral pyrazoles allowed to obtain some new mixed ligands (amino-alcohols, amides, and of β-amino-esters). A C2 symmetric bis-pyrazoles was obtained from 2,2-dimethoxypropane. At a second time, we studied the cycloisomerisation of 1,6-dienes. During this study, we could show that the selectivity of the cyclisation of the diallyle malonate, take as model, depends on the nature of the palladium complex and of its charge. Neutral and monocationic complexes, favour the exclusive formation of a cyclopentene (non-symmetric), whereas dicationic complexes favour the forming of an exomethylene cyclopentane
Grimes-Marchan, Thomas V. "Quantum Perspectives on Physical and Inorganic Chemistry". Thesis, University of North Texas, 2007. https://digital.library.unt.edu/ark:/67531/metadc5172/.
Pełny tekst źródłaNguyen, Xuan Anh. "Synthèse de nouvelles familles de molécules à visée thérapeutique anti-herpétique : optimisation par des approches de "cheminformatique" et de chimie médicinale". Lyon 1, 2006. http://www.theses.fr/2006LYO10203.
Pełny tekst źródłaThe virus of the herpes simplex (HSV-1 and HSV-2) is responsible for the infection of almost 90% to the world population. The infections of the herpes are usually benign, but can cause in certain cases of the serious complications (néo-native herpeses or at immuno-depressed). The disease is all the more contagious as the demonstrations can be asymptomatic. The principal treatment available since the Seventies is containing acyclovir; treatment which one counts case of viral resistance more and more. The starting point of this thesis is the validation by a team of the CNRS of the way of the polyamines like new therapeutic way against the infections of the herpes. An enzyme of this way (the SAMDC) was thus validated like antiherpetic target. The objective of this thesis was thus to synthesize and optimize new active compounds against this indicated target. With this intention, we adopted two complementary access roads: traditional chemistry and rational chemistry. By these two ways we obtained two families of molecules which were then optimized. Finally, we selected two molecules which passed successfully the first test on animal
Rochais, Christophe. "Synthèse et étude physico-chimique de nouvelles pyrrolo- et pyrazolopyrrolizines à visée anticancéreuse". Caen, 2005. http://www.theses.fr/2005CAEN4061.
Pełny tekst źródłaThe work described in this document decides to the synthesis, the physico-chemical study and the biological evaluation of new 3-aryl-pyrrolo[2,3-b]pyrrolizin-8-ones and 3-aryl-pyrazolo[3,4-b]pyrrolizin-8-ones. The discovery of this new family of compounds derives from many research programs developed at the “Centre d'Etudes et de Recherche sur le Médicament de Normandie”. Following a description of different biological targets and their inhibitors, previous works carried in our laboratory about a new heterocyclic family the “tripentones” are reviewed. The development of new pyrrolic and pyrazolic aminoesters and their use for the synthesis and study of novel tripentones in these series constitute the main subject of this thesis. Their prospective anticancer properties are supported by pharmacological results. Lastly, a molecular modelling study that opens new prospects for pharmacomodulation is presented. The experimental part describes the procedures and the physicochemical properties of all the compounds presented. Incidentally, more than 200 bibliographical references are cited
Delaunay, Thierry. "Synthèses concises de pyrazoles et pyridones diversement fonctionnalisées dans le but d’effectuer des réactions de couplages croisés sélectifs". Thesis, Lyon 1, 2010. http://www.theses.fr/2010LYO10274/document.
Pełny tekst źródłaThis thesis is subdivided into two principal parts. The first part is focussed on the synthesis of pyrazole derivatives of agrochemical relevance. Indeed, the pyrazole nucleus is found in numerous compounds possessing interesting biological properties, and notably antifungal activities. Various convergent approaches to diversely substituted pyrazoles have therefore been developed by means of site-selective palladium-catalyzed cross-coupling reactions conducted sequentially on pyrazole scaffolds. In the second part, we have been involved in the synthesis of furopyridones as simplified analogues of natural compounds possessing antifungal activities such as Cladobotryal. Toward this end, various alkynylpyridones have been synthesizes and involved in diverse cyclization processes to access a series of furo[3,2-c]pyridin-4-ones, furo[3,2-c]pyridin-6-ones, and furo[2,3-b]pyridin-4-ones
Pinar, Ayse Nur. "Reaction Of Propargyl Aldehydes With Hydrazinium Salts: Synthesis Of Ferrocenyl And Phenyl Substituted Pyrazoles". Master's thesis, METU, 2008. http://etd.lib.metu.edu.tr/upload/3/12609769/index.pdf.
Pełny tekst źródłaSantos, Nádia Alexandra Esteves. "Synthesis and evaluation of new pyrazoles, glycosylpyrazoles and rutheniumpyrazoles for antioxidant and antitumoral activity". Master's thesis, Universidade de Aveiro, 2017. http://hdl.handle.net/10773/22521.
Pełny tekst źródłaO cancro é a segunda maior razão de morte em Portugal, a seguir às doenças cardiovasculares. A quimioterapia continua a ser o tratamento mais utilizado e eficaz, no entanto o intervalo onde a dose é eficiente e ao mesmo tempo segura ainda é muito pequeno, podendo ser tóxico para o organismo do paciente. Dessa forma, a procura de novos agentes antitumorais eficientes e seguros tem sido crucial, tendo os pirazóis e os complexos de ruténio (II) um papel muito importante. Vários compostos contendo o anel de pirazol nas suas estruturas já demonstraram grande poder antitumoral ao inibirem enzimas cinases, tais como as aurosa cinases e as cinases dependentes de ciclina, ao induzirem a apoptose e até agindo como agentes citotóxicos contra linhas celulares tumorais. Os complexos de ruténio, por sua vez, contribuem para uma ação antitumoral mais seletiva, por terem propriedades redox ou pela incorporação de ligandos lábeis que criam locais de ligação a biomoléculas. Neste trabalho pretende-se sintetizar novos derivados de pirazol, proceder à sua glicosilação e ligação com um complexo de ruténio. Serão feitos estudos de citotoxicidade dos compostos sintetizados, para estudar o seu efeito antitumoral, e ainda testes para avaliar a sua atividade antioxidante, uma vez que a formação de espécies reativas de oxigénio, inflamação crónica e o desenvolvimento de cancro, estão muitas vezes associados. Com base nestes estudos estabelecer-se-ão importantes relações estrutura-atividade biológica que ajudarão a perceber quais os requisitos estruturais mais importantes para a atividade destes compostos.
Cancer is the second main cause of death in Portugal, after cardiovascular diseases. Chemotherapy is still the most used and effective treatment, however the window in which the dose is still safe and efficient is small and consequently it can be toxic to patient’s body. For that reason, the design and discovery of non-traditional antitumoral agents that are both efficient and safe is a key research issue, where pyrazoles and ruthenium (II) complexes have an important role. Several pyrazole-derived compounds have already demonstrated great antitumoral activity by inhibiting kinase enzymes such as aurora kinases and cyclin-dependent kinases, by inducing apoptosis and also by being cytotoxic to several cancer cell lines. Ruthenium complexes contribute to the antitumoral action by having redox properties and by being able to incorporate labile ligands that create, in vivo, active bonding sites for biomolecules. The present work aims the synthesis of new pyrazole derivatives, following by their glycosylation and incorporation into ruthenium(II) complexes. Cytotoxicity studies will be carried out to evaluate their antitumoral effect. In addition, antioxidant activities will be studied since reactive oxygen species, chronic inflammation and cancer development are often connected. Finally, important structure-activity relationships will be established, based on the results of the biological tests, highlighting the key structural requirements needed for the activity of these compounds.
RAPETTI, FEDERICA. "New different catecholic and heterocyclic compounds able to interfere with different pathways in inflammation and cancer". Doctoral thesis, Università degli studi di Genova, 2022. http://hdl.handle.net/11567/1083981.
Pełny tekst źródłaScammells, Peter J., i n/a. "Pyrazolo(3,4-d)Pyrimidines and adenosine receptors: a structure/activity study". Griffith University. Division of Science and Technology, 1990. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20050826.141630.
Pełny tekst źródłaDunham, Jason C. "Synthesis of 4-alkyl-3,5-diamino-1-phenylpyrazoles". Virtual Press, 2006. http://liblink.bsu.edu/uhtbin/catkey/1339144.
Pełny tekst źródłaDepartment of Chemistry
Frideling, Aline. "Composés pyrazoliques et tétrahydroacriniques dérivant d'un squelette monoterpénique". Aix-Marseille 3, 2001. http://www.theses.fr/2001AIX30057.
Pełny tekst źródłaTetrahydroacridines are an important component category, because of their biological activity, for example their effect on Alzheimer disease. Pyrazoles are frequent compounds in many aspects of organic chemistry. We synthetized new molecules of those two families, with, as precursors, optically actives monoterpenic ketones. Synthesis were made by two ways, classical methods and microwaves assisted synthesis. We found new way to obtain 1,2,3,4-tetrahydroacridones, 9-chloro-1,2,3,4-tetrahydroacridines and 9-amino-1,2,3,4-tetrahydroacridines. With assisted synthesis we made an hybrid between pyrazoles and tetrahydroacridines, and made a trimerisation of pyrazoles
Scammells, Peter. "Pyrazolo(3,4-d)Pyrimidines and adenosine receptors: a structure/activity study". Thesis, Griffith University, 1990. http://hdl.handle.net/10072/365214.
Pełny tekst źródłaThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
Division of Science and Technology
Full Text
Kivrak, Arif. "Development Of New Methods For The Synthesis Of Pyrazoles, 4-iodopyrazoles, Isoxazoles And 1,2,4-oxadiazoles". Phd thesis, METU, 2011. http://etd.lib.metu.edu.tr/upload/12612945/index.pdf.
Pełny tekst źródła,&beta
-alkynic hydrazones by molecular iodine and copper iodide were investigated as new ways for the synthesis of 4-iodopyrazoles and pyrazoles, respectively. Initially, &alpha
,&beta
-alkynic hydrazones were prepared by the reactions of propargyl aldehydes and ketones with hydrazines. Then &alpha
,&beta
-alkynic hydrazones were treated with molecular iodine in the presence of NaHCO3, which afforded 4-iodopyrazoles in good to excellent yields. Subsequently, the same reactions were carried out with CuI in the presence of NEt3, which furnished corresponding pyrazoles in good yields. Moreover, ferrocenyl-substituted 4-iodopyrazoles and pyrazole derivatives were synthesized from corresponding
Prado, Guilherme Cervi. "Study of reaction parameters in ball mill in the Synthesis of aryl(heteroaryl)-1h-pyrazoles". Universidade Federal de Santa Maria, 2012. http://repositorio.ufsm.br/handle/1/10505.
Pełny tekst źródłaIn order to eliminate the problems related to deficient intake of vitamins folate class, many food products are being subjected to the enrichment process. Among them, all types of wheat flour must be enriched with folic acid. Therefore, it is evident the need of analytical methods for routine able to effectively determine the levels of folic acid in enriched matrix. The objective of this work was the development and validation of a rapid method for determination of folic acid added to wheat flour, using the technique of high performance liquid chromatography with UV detection. Folic acid was separated using a C8 column. Was used for elution gradient mobile phase with water acidified with glacial acetic acid (pH 2.8) and acetonitrile. Detection was performed with a diode array detector employing a wavelength of 290 nm. External standard was used for quantification. Vitamin matrix was extracted with aqueous potassium hydroxide, 0.1 mol L-1 and aqueous sodium tetraborate 0.04 mol L-1 pH 8.5, followed by cleaning step of the extract of the sample through SPE using SAX cartridges. The method was efficient, with recovery values between 96 and 99%, RSD from 1.3 to 3.8% and LOD and LOQ of 0.28 and 0.937 mg kg-1, respectively. In the analysis of real samples of five brands tested, only one brand presented concentration of folic acid above the minimum required by law.
Com o objetivo de suprimir os problemas relacionados à deficiência de ingesta de vitaminas da classe dos folatos, muitos produtos alimentícios estão sendo submetidos ao processo de enriquecimento. Entre eles, todos tipos de farinha de trigo devem ser enriquecidos com ácido fólico. Portanto, fica evidenciada a necessidade de métodos analíticos para a rotina capazes de determinar com eficácia os níveis de ácido fólico na matriz enriquecida. O objetivo deste trabalho foi o desenvolvimento e validação de um método rápido para determinação de ácido fólico adicionado a farinha de trigo, através da técnica de cromatografia líquida de alta eficiência com detector espectrofotométrico. O ácido fólico foi separado utilizando-se coluna de C8. Utilizou-se eluição por gradiente na fase móvel, com água acidificada com ácido acético glacial (pH 2,8) e acetonitrila. A detecção foi efetuada com detector por arranjo de diodos empregando o comprimento de onda de 290 nm. Foi utilizada padronização externa para quantificação. A vitamina foi extraída da matriz com solução aquosa de hidróxido de potássio 0,1 mol L-1 e solução aquosa de tetraborato de sódio 0,04 mol L-1 de pH 8,5; seguida por etapa de limpeza do extrato da amostra através de SPE, utilizando cartuchos de SAX. O método mostrou-se eficiente, com valores de recuperação entre 96 e 99%, RSD de 1,3 a 3,8% e LOD e LOQ de 0,28 e 0,937 mg kg-1, respectivamente. Nas análises das amostras reais, das cinco marcas analisadas, somente uma marca apresentou concentração de ácido fólico acima do mínimo exigido pela legislação.
Grosse, Sandrine. "Imidazo[1, 2-b]pyrazoles, imidazo[1, 2-a]imidazoles : synthèse, fonctionnalisation et évaluation biologique". Thesis, Orléans, 2013. http://www.theses.fr/2013ORLE2056.
Pełny tekst źródłaImidazo[1,2-b]pyrazoles and imidazo[1,2-a]imidazoles are entities with some interesting applications in pharmacology. However, despite this potential, few methods of preparation and direct functionalisation of the heterocyclic moiety have been described. In this context, the overall goal of our research is to develop new routes to these bicyclic systems from readily available starting materials. Strategies of functionalisation of the heterocyclic moiety were then explored in order to design diversified libraries for the evaluation of potential biological activities. Herein, the results of the tests of imidazo[1,2-b]pyrazole series against various cancer lines are reported
Paul, Tobias [Verfasser], i Nicolai [Akademischer Betreuer] Burzlaff. "Ligands and Coordination Chemistry Based on Vinyl and Alkynyl Substituted Pyrazoles / Tobias Paul. Gutachter: Nicolai Burzlaff". Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2015. http://d-nb.info/1076120520/34.
Pełny tekst źródłaAubert, Philippe. "Bis-silanes propargyliques et bis-propargyliques : applications en synthèse". Poitiers, 1996. http://www.theses.fr/1996POIT2286.
Pełny tekst źródłaDespotopoulou, Christina. "Br/Mg-Exchange on 1,2-Dibromocyclopentene Derivatives and Regio- and Chemoselective Functionalizations of Pyrazoles and Related Heterocycles". Diss., lmu, 2009. http://nbn-resolving.de/urn:nbn:de:bvb:19-104233.
Pełny tekst źródłaWiley, Jack Scott. "C-H bond activation in iridium complexes /". Thesis, Connect to this title online; UW restricted, 1999. http://hdl.handle.net/1773/8510.
Pełny tekst źródłaDelaunay, Thierry. "Synthèses concises de pyrazoles et pyridones diversement fonctionnalisées dans le but d'effectuer des réactions de couplages croisés sélectifs". Phd thesis, Université Claude Bernard - Lyon I, 2010. http://tel.archives-ouvertes.fr/tel-00878928.
Pełny tekst źródłaKolodych, Sergii. "Recherche de nouvelles réactions de couplage par criblage immuno-enzymatique". Thesis, Paris 11, 2013. http://www.theses.fr/2013PA112145.
Pełny tekst źródłaDiscovery of new reactions is one of the fundamental goals in organic chemistry. In addition to the traditional approach to reaction discovery, consisting in designing a reaction on the basis of known chemical properties of reagents, new approaches based on the screening of random combinations of reactive functions and catalysts have been recently developed. The main prerequisite of this strategy is an analytical tool allowing screening of a big number of reactions per day and identifying combinations leading to the formation of unanticipated products. In the work presented herein a high-throughput immunoassay screening has been used for the discovery of new coupling reactions. In the first part of this work a screening of 2688 combinations of randomly chosen reactive functions and catalysts was carried out. This screening led to the discovery of two copper-promoted coupling reactions: a reaction between thioureas and phenols leading to the formation of isoureas through desulfurization; and a reaction between N-hydroxythioureas and alkynes leading to the formation of thiazole-2-imines. In the second part of the work a screening of 2816 combinations of rationally designed chemical functions and catalysts was carried out. This screening was focused on the discovery of catalytic [3+2] cycloadditions that comply with the standards of “click” chemistry. In this study, the use of immunoassay screening was extended to optimize new reactions and to evaluate their kinetics, chemoselectivity and biocompatibility. Therefore, around 3000 complementary tests were carried out on the hits, identified in the primary screening. This allowed the discovery of 3 new coupling reactions and one new “click” reaction: a copper-catalyzed sydnone-alkyne cycloaddition (CuSAC). The last part of the work was focused on detailed studies of the CuSAC reaction. Identification of the structure of the coupling product and substrate scope of this reaction was carried out. Finally, the applicability of the CuSAC reaction for bioconjugation was demonstrated by an example of protein labeling
Ainooson, Michael Kojo. "Binuclear late transition metal complexes with pyrazole based compartmental ligands: Scaffolds for cooperative organometallic transformations". Doctoral thesis, Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2014. http://hdl.handle.net/11858/00-1735-0000-0023-98FC-E.
Pełny tekst źródłaRaboisson, Pierre. "Développement d'inhibiteurs de phosphodiestérase 4 et conception d'antagonistes purinergiques P2Y1 à partir de dérivés de l'adénine et de leurs analogues structuraux". Université Louis Pasteur (Strasbourg) (1971-2008), 2000. http://www.theses.fr/2000STR13243.
Pełny tekst źródłaBenderitter, Pascal Bourguignon Jean-Jacques. "Synthèse et intérêt pharmacologique d'analogues azahétérocycliques de la tétrahydroisoquinoline". Strasbourg : Université Louis Pasteur, 2008. http://eprints-scd-ulp.u-strasbg.fr:8080/939/01/BENDERITTER_Pascal_2006.pdf.
Pełny tekst źródłaRosales, Pauline Fagundes. "Bi-heterociclos a partir do Ácido Levulínico: Síntese de 5-[(5-(trifluormetil)-5-hidroxi-(3-substituido)-4,5-diidro-1H-pirazol-1-il)-1-propan-1-ona-3-il]-2-metil-7-trifluormetil)pirazolo[1,5-a]pirimidinas". Universidade Federal de Santa Maria, 2013. http://repositorio.ufsm.br/handle/1/10535.
Pełny tekst źródłaAn efficient method to obtain 2-methyl-5-(methylpropanoate-3-yl)-7-trifluoromethylpyrazolo[1,5-a]pyrimidine 2 from the reaction of compound methyl 7,7,7-trifluoro-4-methoxy-6-oxo-heptenoate with 3-amino-5-methyl-1H-pyrazol. This compound 2 brought to reaction with hydrazine monohydrate to obtain 2-methyl-7-trifluoromethylpyrazolo[1,5-a]pyrimidine-5-propanehydrazine 3 and after were later brought to cyclocondensation reaction with a series of β-alkoxyvinyltrifluoromethyl ketones giving the series of news bi-heterocyclic 5-[(5-(trifluoromethyl)-5-hydroxy- (3-substituted)-4,5-dihydro-1H-pyrazol-1-yl)-1-propan-1-one-3-yl]-2-methyl-7-trifluoro methyl)pyrazolo[1,5-a]pyrimidines compounds 5a-l. Compound 2-methyl-5-(methylpropanoate-3-yl)-7-trifluoromethylpyrazolo[1,5-a]pyrimidine 2 brought to transesterification reaction and hydrolises reaction for obtaining the compounds 6 and 7. The structures of all synthesized compounds were confirmed by 1H, 13C, 19F NMR data, and two-dimensional NMR techniques like HETCOR and COLOC, mass spectrometry data.
Este trabalho descreve um método eficiente para a obtenção de 2-metil-5-(propanoato-3-il de metila)-7-trifluormetilpirazolo[1,5-a]pirimidina 2 a partir da reação de ciclocondensação do composto 7,7,7-trifluor-4-metoxi-6-oxo-4-heptenoato de metila com 3-amino-5-metil-1H-pirazol. Este composto 2 foi levado à reação com monohidrato de hidrazina obtendo-se a 2-metil-7-trifluormetilpirazolo[1,5-a]pirimidina-5-propanohidrazina 3. Posteriormente, o composto 3 foi levado à reação de ciclocondensação do tipo [3+2] com uma série de β-alcoxivniltrifluormetil cetonas alquil e aril substituídas utilizando etanol como solvente, resultando em uma série de compostos bi-heterocíclicos inéditos 5-[(5-trifluormetil)-5-hidróxi-(3-substituidos)-4,5-diidro-1H-pirazol-1-il)-1-propan-1-ona-3-il]-2-metil-7-trifluormetilpirazolo[1,5-a]pirimidina 5a-l. O composto 2-metil-5-(propanoato-3-il de metila)-7-trifluormetilpirazolo[1,5-a]pirimidina 2 foi levado à reação de transesterificação e à reação de hidrólise para a formação dos respectivos compostos 6 e 7. As estruturas de todos os compostos sintetizados foram confirmadas por dados de RMN 1H, 13C, 19F e técnicas de RMN bidimensionais como HETCOR e COLOC, além de dados de espectrometria de massas.