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Artykuły w czasopismach na temat „Ps 3730”

Autor: Grafiati

Data publikacji: 29 lipca 2024

Data aktualizacji: 30 lipca 2024

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1

Joseline, Dyana, Radhakrishna G. Pillai i Lakshman Neelakantan. "Initiation of Stress Corrosion Cracking in Cold-Drawn Prestressing Steel in Hardened Cement Mortar Exposed to Chlorides". Corrosion 77, nr 8 (28.05.2021): 906–22. http://dx.doi.org/10.5006/3730.

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Cold-drawn, high-strength, prestressing (PS) steel strands are widely used in pretensioned concrete (PTC) structures. This paper discusses the stress corrosion cracking (SCC) of PS steel embedded in cement mortar and gradually exposed to chlorides. Various stages of the passive to active (P-to-A) transition, which marks the onset of SCC, were investigated using the electrochemical impedance spectroscopy technique. The key mechanisms were identified and confirmed using scanning electron microscopy/energy dispersive x-ray analysis, x-ray diffarction, and confocal Raman spectroscopy. It was found that the passive film on unstressed PS steel has better electrochemical characteristics than that on conventional steel rebars. However, the residual tensile stress at the surface of PS steels can assist passive film cracking after chloride attack—contrary to the pitting corrosion without cracking of passive film in conventional steels. Further, tests indicated that the concentration of chlorides required to crack the passive film in PS steels can reduce by about 50% when prestressed—as in field structures. Chemical composition, stress state, and microstructural features at the PS steel surface were identified as possible factors influencing the initiation of SCC in PTC structures.

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Zarzycki, Stanisław. "Obecność i działanie Ducha Świętego w Eucharystii a postawy duchowe kapłana i wiernych". Polonia Sacra 24, nr 3 (31.10.2020): 165. http://dx.doi.org/10.15633/ps.3730.

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Oka, Yuji. "Nematicidal activity of fluensulfone against some migratory nematodes under laboratory conditions". Pest Management Science 70, nr 12 (25.02.2014): 1850–58. http://dx.doi.org/10.1002/ps.3730.

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Chopin, C., M. Geoffroy, C. Dorilleau, B. Loïs, A. Hittinger, I. Charlot, L. Kanagaratnam i J. H. Salmon. "AB0992 Prognostic factors related to clinical response in 197 patients with knee osteoarthritis treated by platelet rich plasma (PRP)". Annals of the Rheumatic Diseases 81, Suppl 1 (23.05.2022): 1621.2–1621. http://dx.doi.org/10.1136/annrheumdis-2022-eular.3730.

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BackgroundThe European League Against Rheumatism (EULAR) [1] and the Osteoarthritis Research Society International (OARSI) [2] recommend a combination of non-pharmacological and pharmacological treatment in the management of knee osteoarthritis. New therapies have emerged such as Platelet Rich Plasma (PRP) injections. Many studies have shown the effectiveness of this treatment, and even its superiority over Hyaluronic Acid.ObjectivesThe aim of this study was to determine the prognostic factors related to clinical response to PRP injections in knee osteoarthritis, in order to better select candidates for this therapy.MethodsThis was a single-center, prospective observational study including patients treated by PRP injections for knee osteoarthritis, from a university hospital. The PRP was leukocyte-poor, obtained by an ARTHREX kit, and was injected twice, at one-month intervals. They were assessed at 4 months (M4) and 7 months (M7) after the first injection. Pains on a Visual Analog Scale (VAS) and function with Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Knee injury and Osteoarthritis Outcome Score (KOOS) – Physical Function Shortform (KOOS-PS) were collected. Patients were then classified as responders if they met the OMERACT-OARSI criteria at M7. Univariate and multivariate analysis was performed to compare the two groups.ResultsAmong 197 patients, 210 knees were treated. The mean age was 59.8±10.8 years, Body mass index (BMI) was 31.0±6.5. Patellofemoral osteoarthritis was found in 34.3% of the patients, the distribution according to Kellgren and Lawrence stages I, II, III, IV was 11.8%, 33.5%, 40.4% and 14.3% respectively. A majority of patients had failed viscosupplementation (62.4%). At 7 months, 43.8% were classified as responders. Total WOMAC was 49.4±16.1 at M0, 43.6±17.9 at M1, 31.1±19.0 at M4 and 31.9±19.8 at M7, with significant improvement at M4 and M7 versus baseline (p<0.0001). The VAS was 58.5±19.7, 51.6±21.7, 43.7±23.2 and 43.5±23.5 at M0, M1, M4 and M7 respectively (p<0.0001 at all 3 times versus baseline). Regarding treatment satisfaction, 70% of patients considered the treatment effective or very effective at M7. Physical therapy and a heel-buttock distance greater than 35 centimeters were the two criteria associated with a poorer response at M7 on multivariate analysis. The pain VAS at M7 appeared to be lower in patients whose osteoarthritis had been evolving for less than 24 months. Tolerance was good. There was an increase in joint effusions between M0 and M1 (17% vs. 41%, p<0.0001), but no increase in pain.ConclusionPRP treatment in knee osteoarthrisis appeared to be effective and well tolerated, and this response was not associated with the radiographic stage or the type of knee osteoarthritis. In accordance with the recommendations of a group of French experts, this treatment should be proposed in case of failure of drug and rehabilitation treatment, at the same level as hyaluronic acid injections.References[1]Jordan KM et al. EULAR Recommendations 2003: an evidence based approach to the management of knee osteoarthritis: Report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT). Ann Rheum Dis. déc 2003;62(12):1145‑55.[2]Bannuru RR et al. OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis. Osteoarthr. Cartil. nov 2019;27(11):1578‑89.Disclosure of InterestsNone declared

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Agarwal, N. K., i S. K. Agarwal. "Postural instability in schizophrenics: A study using computerized static and dynamic posturography". European Psychiatry 26, S2 (marzec 2011): 1336. http://dx.doi.org/10.1016/s0924-9338(11)73041-3.

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IntroductionSchizophrenic patients have a high incidence of falls and fractures. We evaluated postural stability in schizophrenic patients using computerized static and dynamic posturography (CDP).ObjectivesTo measure normal and perturbed stability in schizophrenics.AimsTo objectively demonstrate postural abnormalities in schizophrenics.MethodsWe retrospectively evaluated CDP studies on 54 consecutive schizophrenic patients. CDP was done using FallTrak (R). Patients performed normal stability - eyes open (NS/EO), normal stability- eyes closed (NS/EC), perturbed stability - eyes open (PS/EO), and perturbed stability - eyes closed (PS/EC) for 30 seconds each. Findings were classified as normal or abnormal based on age-matched normative data.ResultsThe ages ranged from 31 to 77 years. There were 34 (63.0%) males and 20 (37.0%) females. Of the total 54 patients, 48 (88.9%) exhibited abnormalities on CDP testing. NS-EO was abnormal in 29 (53.7%), NS-EC was abnormal in 37 (68.5%); both NS-EO and NS-EC were abnormal in 25 (46.3%); PS-EO was abnormal in 27 (50.0%) and PS-EC was abnormal in 20 (37.0%). Both PS-EO and PS-EC were abnormal in 14 (25.9%). Both PS and NS were abnormal in 26 (48.1%). NS was normal in 13 (24.1%) and PS was normal in 21 (38.9%). Both NS and PS were normal in 6 (11.1%) patients.ConclusionsMost schizophrenic patients show abnormalities in both normal and perturbed stability when tested using static and dynamic posturography. Balance was normal in only 11.1 % of the patients. Further studies are needed to evaluate the clinical significance of these findings.

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Radzlin, Nurfatini, Amira Suriaty Yaakop, Kian Mau Goh, Kok Jun Liew, Iffah Izzati Zakaria i Ummirul Mukminin Kahar. "Genome Analysis of Celeribacter sp. PS-C1 Isolated from Sekinchan Beach in Selangor, Malaysia, Reveals Its β-Glucosidase and Licheninase Activities". Microorganisms 10, nr 2 (10.02.2022): 410. http://dx.doi.org/10.3390/microorganisms10020410.

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A halophilic marine bacterial strain, PS-C1, was isolated from Sekinchan beach in Selangor, Malaysia. The 16S rRNA gene sequence analysis indicated that strain PS-C1 was associated with the genus Celeribacter. To date, there have been no reports on enzymes from the genus Celeribacter. The present study reports on the cellular features of Celeribacter sp. PS-C1, its annotated genome sequence, and comparative genome analyses of Celeribacter glycoside hydrolase (GH) enzymes. The genome of strain PS-C1 has a size of 3.87 Mbp and a G+C content of 59.10%, and contains 3739 protein-coding genes. Detailed analysis using the Carbohydrate-Active enZYmes (CAZy) database revealed that Celeribacter genomes harboured at least 12 putative genes encoding industrially important GHs that are grouped as cellulases, β-glucanases, hemicellulases, and starch-degrading enzymes. Herein, the potential applications of these enzymes are discussed. Furthermore, the activities of two types of GHs (β-glucosidase and licheninase) in strain PS-C1 were demonstrated. These findings suggest that strain PS-C1 could be a reservoir of novel GH enzymes for lignocellulosic biomass degradation.

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Immanuel, O. M., i I. A. Isaiah. "Polystyrene degradation by bacteria isolated from the larvae of <i>Rhynchophorusphoenicis</i>". Nigerian Journal of Biotechnology 40, nr 2 (12.03.2024): 99–106. http://dx.doi.org/10.4314/njb.v40i2.11.

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The larvae of insects of the order Coleoptera have been reported to biodegrade plastics aided by their chewing mouthparts and the activities of their gut biota. However, there is no report of this ability by the African palm weevil (Rhynchophorus phoenicis). This study aims to the ability of R. phoenicis larvae to biodegrade polystyrene (PS). A total of 100 R. phoenicis larvae were fed for 21 days with PS foam, and afterwards, the gut contents of survivors were investigated for possible PS-degrading bacteria. Bacterial isolates were screened for PS biodegradation in an Erlenmeyer flask with PS film as the sole carbon source, in a mineral salt medium (MSM) at a temperature of 30oC and a pH of 7, for a period of 28 days. The isolates were used for biodegradation assay under the same conditions, for 60 days. The weight of PS films was determined before and after the biodegradation assay. Chemical changes in the films were confirmed by Fourier Transform Infrared (FTIR) spectroscopy. Two bacterial isolates were recovered from the gut of the only surviving R. phoenicis larvae fed with 100% PS. The isolates were identified based on their 16S rRNA sequences as Lysinibacillus macriodes and Pantoea dispersa with accession numbers OQ652017 and OQ652023 respectively. The isolates caused an 8.8% reduction in the weight of PS film and FTIR spectroscopy results confirmed the formation of groups suggestive of degradation products with the carbonyl group showing up as absorption peaks in the range of 1640-1760 cm-1 and the hydroxylic group at 3000-3700 cm-1 . The isolates were able to produce polyhydroxyalkanoate (PHA) equivalent to 1.4g/L, under PS degradation conditions. Therefore, coupling the biodegradation of PS with PHAproduction could be useful for the valorization of PS waste.

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Viriyasaranon, Thanaporn, Jung Won Chun, Young Hwan Koh, Jae Hee Cho, Min Kyu Jung, Seong-Hun Kim, Hyo Jung Kim, Woo Jin Lee, Jang-Hwan Choi i Sang Myung Woo. "Annotation-Efficient Deep Learning Model for Pancreatic Cancer Diagnosis and Classification Using CT Images: A Retrospective Diagnostic Study". Cancers 15, nr 13 (28.06.2023): 3392. http://dx.doi.org/10.3390/cancers15133392.

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The aim of this study was to develop a novel deep learning (DL) model without requiring large-annotated training datasets for detecting pancreatic cancer (PC) using computed tomography (CT) images. This retrospective diagnostic study was conducted using CT images collected from 2004 and 2019 from 4287 patients diagnosed with PC. We proposed a self-supervised learning algorithm (pseudo-lesion segmentation (PS)) for PC classification, which was trained with and without PS and validated on randomly divided training and validation sets. We further performed cross-racial external validation using open-access CT images from 361 patients. For internal validation, the accuracy and sensitivity for PC classification were 94.3% (92.8–95.4%) and 92.5% (90.0–94.4%), and 95.7% (94.5–96.7%) and 99.3 (98.4–99.7%) for the convolutional neural network (CNN) and transformer-based DL models (both with PS), respectively. Implementing PS on a small-sized training dataset (randomly sampled 10%) increased accuracy by 20.5% and sensitivity by 37.0%. For external validation, the accuracy and sensitivity were 82.5% (78.3–86.1%) and 81.7% (77.3–85.4%) and 87.8% (84.0–90.8%) and 86.5% (82.3–89.8%) for the CNN and transformer-based DL models (both with PS), respectively. PS self-supervised learning can increase DL-based PC classification performance, reliability, and robustness of the model for unseen, and even small, datasets. The proposed DL model is potentially useful for PC diagnosis.

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Królikowski, Wacław. "Rozeznawanie woli Bożej według św. Ignacego Loyoli". Polonia Sacra 24, nr 3 (31.10.2020): 5. http://dx.doi.org/10.15633/ps.3720.

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Klimek, Jan. "Stygmatyzacja a dobrostan chorych psychicznie – aspekty pastoralne". Polonia Sacra 24, nr 3 (31.10.2020): 185. http://dx.doi.org/10.15633/ps.3731.

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Henriksen, A. "Structure of soybean seed coat peroxidase: A plant peroxidase with unusual stability and haem-apoprotein interactions". Protein Science 10, nr 1 (1.01.2001): 108–15. http://dx.doi.org/10.1110/ps.37301.

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Ma, Che, Francesca M. Marassi, David H. Jones, Suzana K. Straus, Stephan Bour, Klaus Strebel, Ulrich Schubert, Myrta Oblatt-Montal, Mauricio Montal i Stanley J. Opella. "Expression, purification, and activities of full-length and truncated versions of the integral membrane protein Vpu from HIV-1". Protein Science 11, nr 3 (1.01.2009): 546–57. http://dx.doi.org/10.1110/ps.37302.

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Li, Yuan, Liangang Mao, Dongdong Yan, Taotao Ma, Jin Shen, Meixia Guo, Qiuxia Wang, Canbin Ouyang i Aocheng Cao. "Quantification of Fusarium oxysporum in fumigated soils by a newly developed real-time PCR assay to assess the efficacy of fumigants for Fusarium wilt disease in strawberry plants". Pest Management Science 70, nr 11 (7.01.2014): 1669–75. http://dx.doi.org/10.1002/ps.3700.

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Mitchell, Paul D. "Market‐level assessment of the economic benefits of atrazine in the United States". Pest Management Science 70, nr 11 (21.01.2014): 1684–96. http://dx.doi.org/10.1002/ps.3703.

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Yu, Qin, i Stephen B. Powles. "Resistance to AHAS inhibitor herbicides: current understanding". Pest Management Science 70, nr 9 (20.01.2014): 1340–50. http://dx.doi.org/10.1002/ps.3710.

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Aflitto, Nicholas C., i Richard W. Hofstetter. "Use of acoustics to deter bark beetles from entering tree material". Pest Management Science 70, nr 12 (17.02.2014): 1808–14. http://dx.doi.org/10.1002/ps.3720.

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Barbosa, Leonardo da F., Julio M. Marubayashi, Bruno R. De Marchi, Valdir A. Yuki, Marcelo A. Pavan, Enrique Moriones, Jesús Navas-Castillo i Renate Krause-Sakate. "Indigenous American species of the Bemisia tabaci complex are still widespread in the Americas". Pest Management Science 70, nr 10 (4.03.2014): 1440–45. http://dx.doi.org/10.1002/ps.3731.

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McGhee, Peter S., Larry J. Gut i James R. Miller. "Aerosol emitters disrupt codling moth, Cydia pomonella , competitively". Pest Management Science 70, nr 12 (10.03.2014): 1859–62. http://dx.doi.org/10.1002/ps.3732.

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Gauthier, Nathalie, Cécile Clouet, Andreas Perrakis, Despoina Kapantaidaki, Michel Peterschmitt i Anastasia Tsagkarakou. "Genetic structure of Bemisia tabaci Med populations from home-range countries, inferred by nuclear and cytoplasmic markers: impact on the distribution of the insecticide resistance genes". Pest Management Science 70, nr 10 (7.03.2014): 1477–91. http://dx.doi.org/10.1002/ps.3733.

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Gilioli, Gianni, Sara Pasquali, Simone Parisi i Stephan Winter. "Modelling the potential distribution ofBemisia tabaciin Europe in light of the climate change scenario". Pest Management Science 70, nr 10 (26.02.2014): 1611–23. http://dx.doi.org/10.1002/ps.3734.

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Dombrovsky, Aviv, Victoria Reingold i Yehezkel Antignus. "Ipomovirus - an atypical genus in the family Potyviridae transmitted by whiteflies". Pest Management Science 70, nr 10 (3.03.2014): 1553–67. http://dx.doi.org/10.1002/ps.3735.

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McKenzie, Cindy L., Vivek Kumar, Cristi L. Palmer, Ronald D. Oetting i Lance S. Osborne. "Chemical class rotations for control ofBemisia tabaci(Hemiptera: Aleyrodidae) on poinsettia and their effect on cryptic species population composition". Pest Management Science 70, nr 10 (3.03.2014): 1573–87. http://dx.doi.org/10.1002/ps.3736.

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Gorovits, Rena, Adi Moshe, Murad Ghanim i Henryk Czosnek. "Degradation mechanisms of theTomato yellow leaf curl viruscoat protein following inoculation of tomato plants by the whiteflyBemisia tabaci". Pest Management Science 70, nr 10 (4.03.2014): 1632–39. http://dx.doi.org/10.1002/ps.3737.

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Polston, Jane E., Paul De Barro i Laura M. Boykin. "Transmission specificities of plant viruses with the newly identified species of theBemisia tabacispecies complex". Pest Management Science 70, nr 10 (3.03.2014): 1547–52. http://dx.doi.org/10.1002/ps.3738.

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Kliot, Adi, Svetlana Kontsedalov, John S. Ramsey, Georg Jander i Murad Ghanim. "Adaptation to nicotine in the facultative tobacco-feeding hemipteranBemisia tabaci". Pest Management Science 70, nr 10 (6.03.2014): 1595–603. http://dx.doi.org/10.1002/ps.3739.

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Lazzarini, A. L. Fantola, i E. Lazzarini. "Role of the solvent dielectric constant in o-Ps quenching reactions". Journal of Physics B: Atomic and Molecular Physics 20, nr 1 (14.01.1987): 183–97. http://dx.doi.org/10.1088/0022-3700/20/1/020.

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Reshetnyak, T., F. Cheldieva, M. Cherkasova, A. Lila i E. Nasonov. "POS0766 THE ROLE OF ANTIBODIES TO THE PHOSPHATIDYLSERINE/PROTHROMBIN COMPLEX IN THE DIAGNOSIS OF ANTIPHOSPHOLIPID SYNDROME". Annals of the Rheumatic Diseases 81, Suppl 1 (23.05.2022): 670.1–670. http://dx.doi.org/10.1136/annrheumdis-2022-eular.3859.

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BackgroundThe study of other non-criteria antiphospholipid antibodies (aPL) may improve the stratification of patients with antiphospholipid syndrome (APS) and assist in the interpretation of conflicting results on aPL testing.ObjectivesTo determine the significance of antibodies to the phosphatidylserine/prothrombin complex (anti-PS/PT) in patients with systemic lupus erythematosus (SLE) and APS.MethodsThe study included 190 patients who signed informed consent, aged 37,0 [29,0-44,0] years and disease duration 7,0 [2,0-15,0] years. Male/female ratio was 44 (23)/146 (77). 123 (64,7%) of 190 patients had reliable SLE and 55 (29%) had PAPS. The control group was left with 100 relatively healthy, age-matched individuals. Classical aPL (IgG/IgM-aCL, IgG/IgM-αβ2-GP1, LA) were meassured at two time points separated by at least 12 weeks in all patients included in this study. IgG/IgM anti-PS/PT was determined by enzyme immunoassay (ELISA) using a Tecan sunrise absorbance microplate spectrophotometer (Austria) with an AESKULISA Serin-Prothrombin-GM antibody reagent kit. IgG/IgM anti-PS/PT were measured in U/ml. Values >18 U/ml were considered positive. The range of measurements was: 1 to 300 U/ml.ResultsIn 144 (76%) of 190 patients were revealed IgG anti-PS/PT, 55 (29%) - IgM anti-PS/PT, a combination of IgG anti-PS/PT and IgM anti-PS/PT was found in 53 (28%). IgG anti-PS/PT and IgM anti-PS were detected in 39 of the 70 (56%) remaining patients who were negative for criterion aPL. The median IgG anti-PS/PT was 101.2 U/ml [31,0-180,5] in patients with APS and was significantly higher than 23,7 [14,1-49,8] U/ml in patients without APS and controls. IgM anti-PS/PT levels in patients with and without APS were comparable. Thrombosis was significantly more common in patients with IgG anti-PS/PT: 95 (81,2%) of 117 patients with thrombosis compared with patients negative for IgG anti-PS/PT (22 (18,8%) of 46 patients) (χ2=4,85; P=0,03). Arterial, but not venous thrombosis, was associated with IgG anti-PS/PT positivity. IgG anti-PS/PT was detected in 53 (88,3%) of 60 patients with arterial thromboses, and in 7 (11,7%) of 46 patients of IgG anti-PS/PT negative. The incidence of thrombocytopenia in the SLE+APS patient group was associated with the presence of IgG anti-PS/PT, which was detected in 18 of 19 patients, versus 6 of 12 in SLE without aPL (P<0,007). In the other patient groups, the frequency of thrombocytopenia and IgG anti-PS/PT positivity was not statistically significant. The frequency of anti-PS/PT detection was independent of LA positivity. IgG and/or IgM anti-PS/PT were detected in 26 (87%) of 30 patients positive for LA and in 21 (78%) of 27 patients LA negative. (P<0,05). The sensitivity of anti-PS/PT IgG for APS was 85%, specificity - 64%, the sensitivity of anti-PS/PT IgM was lower - 35%, but higher specificity - 88%.ConclusionThe frequency of anti-PS/PT detection in the examined patients was high: 76% had IgG anti-PS/PT, 29% - IgM anti-PS/PT and 28% - a combination of them. The levels of IgG anti-PS/PT were significantly higher in patients with APS compared to patients without APS and controls. IgM anti-PS/PT values in patients with and without APS were comparable but higher compared to controls. Thrombosis was associated with IgG anti-PS/PT positivity. Arterial thrombosis was significantly more frequent in patients with IgG anti-PS/PT (χ2=4,85; P=0,006). The sensitivity of IgG anti-PS/PT for APS was 85%, and specificity was 64%; IgM anti-PS/PT had a lower sensitivity of 35%, but a higher specificity of 88%.The study was performed at the V.A. Nasonova Research Institute of Rheumatology within the framework of the fundamental topic FURS-2022-003.Disclosure of InterestsNone declared

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Fujioka, H., H. Kunizawa i K. Ura. "0.1 ps resolution delay circuit for waveform measurement in the stroboscopic scanning electron microscope". Journal of Physics E: Scientific Instruments 19, nr 12 (grudzień 1986): 1025–26. http://dx.doi.org/10.1088/0022-3735/19/12/007.

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Soults, Frank. "The Many Faces of Shame—edited by Donald L. Nathanson, M.D.; New York, Guiiford, 1987, 370 pages, $30". Psychiatric Services 39, nr 9 (wrzesień 1988): 1000–1001. http://dx.doi.org/10.1176/ps.39.9.1000.

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Liu, Dawei, Simon J. Hollis, Harry C. P. Dymond, Neville McNeill i Bernard H. Stark. "Design of 370-ps Delay Floating-Voltage Level Shifters With 30-V/ns Power Supply Slew Tolerance". IEEE Transactions on Circuits and Systems II: Express Briefs 63, nr 7 (lipiec 2016): 688–92. http://dx.doi.org/10.1109/tcsii.2016.2530902.

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Pospieszalska-Surdej, A., J. Surdej i P. Veron. "The ‘Gravitational Lensing’ Bibliography". Symposium - International Astronomical Union 173 (1996): 415–16. http://dx.doi.org/10.1017/s0074180900231938.

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We present a non-exhaustive bibliography on “Gravitational Lensing” (GL), totalizing nearly 1500 titles (see Pospieszalska-Surdej et al. 1993 for an earlier version of this bibliography). It also includes recent abstracts of papers dealing with gravitational lensing and submitted to astro-ph@babbage.sissa.it. The GL bibliography is accessible through a World-Wide-Web page at the URL (cf. next page) http://www.stsci.edu/ftp/stsci/library/grav_lens/grav_lens.html It is also possible to retrieve -via FTP- the latex file ‘grav_bib1.tex’ or the postscript file ‘grav_bib1.ps’ containing the most recent version of this bibliography. Please proceed as follows: ftp stsci.edu, Name: anonymous, Password: your E-mail address, cd stsci/library/grav_lens, get grav_bib1.tex or get grav_bib1.ps, and finally bye).We are aware that the present compilation is not complete, not always uniform and that there are still errors, typos, etc. We would appreciate very much if you could communicate to us (via E-mail: surdej@stsci.edu) missing or new titles (published or accepted for publication), errors, changes and suggestions. It would also be nice for us to receive in the future your preprints or reprints related to ‘Gravitational Lensing’ studies. Please send your material to: A. Pospieszalska-Surdej, STScI, 3700 San Martin Drive, Baltimore MD 21218, USA.

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Laricchia, G., M. Charlton, S. A. Davies, C. D. Beling i T. C. Griffith. "The production of collimated beams of o-Ps atoms using charge exchange in positron-gas collisions". Journal of Physics B: Atomic and Molecular Physics 20, nr 3 (14.02.1987): L99—L105. http://dx.doi.org/10.1088/0022-3700/20/3/006.

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Choi, EH, HS Kim, BJ Lee, HJ Lee, HG Kang, IS Ha i HI Cheong. "PS-370 Outcome Of Antimicrobial Therapy Of Paediatric Urinary Tract Infections Caused By Extended-spectrum ß-lactamase-producing Enterobacteriaceae". Archives of Disease in Childhood 99, Suppl 2 (październik 2014): A245.2—A245. http://dx.doi.org/10.1136/archdischild-2014-307384.668.

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Kinney, Jean. "Alcoholism and Substance Abuse in Special Populations—by Gary W. Lawson, Ph.D., and Ann W. Lawson, Ph.D.; Rockville, Maryland, Aspen Publications, 1989, 370 pages, $44". Psychiatric Services 42, nr 6 (czerwiec 1991): 643. http://dx.doi.org/10.1176/ps.42.6.643.

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Bruna, P. J., i F. Grein. "The low-lying electronic states X3Σ-, a1Δ and b1Σ+of PO-, NS-and PS-according to MRD-CI calculations". Journal of Physics B: Atomic and Molecular Physics 20, nr 22 (28.11.1987): 5967–86. http://dx.doi.org/10.1088/0022-3700/20/22/010.

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McDaniel, Ellen G. "Clinical Assessment of Malingering and Deception—edited by Richard Rogers, Ph.D.; New York, Guilford Press, 1988, 370 pages, $39.50". Psychiatric Services 41, nr 7 (lipiec 1990): 809—a—810. http://dx.doi.org/10.1176/ps.41.7.809-a.

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Agafonov, G. V., T. S. Kovaleva, A. N. Yakovlev, A. S. Muravev i S. F. Yakovleva. "Optimization of water-heat treatment of barley batch (mix) in ethanol production". Proceedings of the Voronezh State University of Engineering Technologies 82, nr 3 (19.10.2020): 131–38. http://dx.doi.org/10.20914/2310-1202-2020-3-131-138.

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Barley is a problematic raw material for ethanol processing due to its chemical composition. ?-glucans and pentosans high content increases the mass viscosity and digestible carbohydrates loss at еру water-heat treatment stage. The enzymes used to pre-treat grain prior to fermentation are traditionally ?-amylases and glucoamylases. The purpose of the work is to determine the optimal ratio of enzymes introduced in different periods of water-heat treatment. The object of study was barley: starch 52, protein 11.5, hemicellulose 5.1, ?-glucan 3.9, moisture 14.0. Enzyme preparations Alphaferm 3500L (0.5–1.0 AC / g starch), ViscoStar 150L (3700 units KS / cm3; 140 units ? – GcS / cm3; 1900 units CMC / cm3.), Prolive BS Liquid (600-750 units PS / cm?) were used in the work. The dynamics of viscosity change in the process of water-heat treatment was investigated in the work as well. It was found out that the dosage of the enzyme preparation Alphaferm 3500L has the greatest effect on the mass fraction of dry substances in the filtrate of barley mix, while the dosage of other enzyme preparations and the duration of the experiment have a smaller and similar effect. It was proved that the application of a multienzyme complex reduces the viscosity by 82% compared to the control. The method of indefinite Lagrange multipliers was used to determine the optimal mode of water-heat treatment. It was found out that the maximum accumulation of dry substances in the mixture is 16.4% and is achieved after 2.5 hours with the following doses of enzyme preparations: Alphaferm 3500 L - 0.6 units. AC / g starch; ViscoStar 150L - 0.025 units GCS / g starch; Prolyve BS Liquide 0.25 units PS / g starch.

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Batra, Atul, Ravi Ramjeesingh, Brandon M. Meyers, Michael M. Vickers, Rachel Anne Goodwin, Dawn Elizabeth Armstrong, Winson Y. Cheung i Christina Kim. "Treatment patterns and survival outcomes of older patients with advanced pancreatic cancer (APC): A Canadian real-world evidence study." Journal of Clinical Oncology 39, nr 3_suppl (20.01.2021): 385. http://dx.doi.org/10.1200/jco.2021.39.3_suppl.385.

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385 Background: We aimed to compare chemotherapy regimens used and overall survival (OS) among geriatric patients (≥ 75 years) with APC as compared to old (65-74 years) and young (< 65 years) patients with APC. Methods: In this retrospective population-based analysis, we identified patients with APC (defined as inoperable/metastatic disease) from 5 large provinces in Canada who were diagnosed from 2011 to 2016. Kaplan-Meier curves were plotted to derive OS and multivariable Cox regression models were constructed to determine the associations of different age groups on OS. Results: We included 636 patients diagnosed with APC of whom 258 (40.6%), 247 (38.8%) and 131 (20.6%) were young, old and geriatric. Approximately half (45.7%) of all patients were women. Eastern Cooperative Oncology Group performance status (ECOG PS) was known in 508 patients at diagnosis among whom 62.2% were 0-1 and 37.8% were 2+. ECOG PS was more likely to be 2+ in the geriatric group (46.8% vs 41.1% vs 31.3%; P = 0.017). Most patients (95.8%) had metastatic disease while the remaining patients had inoperable locally advanced disease. Within the study cohort, 38.7% received chemotherapy. Treatment rates differed based on age: 41.9% in young patients, 40.9% in old patients and 28.2% in geriatric patients (P = 0.02). Choice of first-line chemotherapy varied and included FOLFIRINOX (F) in 99 (40.2%), gemcitabine and nab-paclitaxel (GN) in 91 (37.0%) and gemcitabine (G) in 56 (22.8%). F, GN and G were administered in 27.0%, 32.4% and 40.5% of geriatric patients, 40.6%, 32.7% and 26.7% of old patients, and 44.4%, 42.6% and 13.0% of young patients, respectively (P = 0.007). After adjusting for baseline factors, both geriatric (odds ratio [OR], 0.70; 95% confidence interval [CI], 0.42-1.17; P = 0.175) and old patients were as likely to receive chemotherapy (OR, 1.04; 95% CI, 0.70-1.56; P = 0.815) as their young counterparts. The median OS was 7.1 (6.3-8.4), 6.7 (5.5-8.9) and 5.3 (4.3-6.8) months in young, old and geriatric patients, respectively. After adjusting for baseline variables, both geriatric (hazard ratio [HR], 1.25; 95% CI, 0.96-1.62; P = 0.101) and old patients (HR, 1.16; 95% CI, 0.94-1.42; P = 0.171) experienced similar OS as young patients. ECOG PS 2+ at presentation was associated with worse OS as was treatment with G. Conclusions: Overall treatment rates for APC are low in the real world. The poor OS in geriatric patients with APC is driven by poor PS and use of less intensive chemotherapy. Age alone should not be considered a contraindication for more intensive chemotherapy since treatment benefit is observed across all age groups. [Table: see text]

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Qianqian Hu. "Product Design Interaction and Experience Based on Virtual Reality Technology". Journal of Electrical Systems 20, nr 7s (16.05.2024): 1571–83. http://dx.doi.org/10.52783/jes.3735.

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Artificial intelligence involves imitating human thought, consciousness, and other aspects. This is similar to having machine with human brain that can think, produce independently. However, unlike human brain, it has a speed, memory advantage. A virtual reality interactive glove is built using a nine-axis inertial sensor, an artificial intelligence deep learning algorithm. In this research work, Product Design Interaction and Experience Based on Virtual Reality Technology (PDIE-VRT-SCGAN) were proposed. Initially, input gestures data are gathered from the Virtual Reality Experiences (VRE) dataset. The input gestures data is then pre-processed using Multi-Window Savitzky-Golay Filter (MWSGF) to reduce noises, increase overall quality of the gestures data. In order to improving overall user engagement in product design interactions on virtual reality (VR) technology, the pre-processed gestures data are then fed into an adversarial network called a Semi-Cycled Generative Adversarial Network (SCGAN). In general, SCGAN does not express some adaption of optimization strategies for determining optimal parameters to promise exact to improving overall user engagement in product design interactions using VR technology. Therefore, FOX-inspired Optimization (FIO) is proposed to enhance weight parameter of SCGAN method, which precisely improving the user experience in product design interaction. The efficacy of PDIE-VRT-SCGAN method is assessed using a number of performance criteria, including tracking accuracy, frame rate, latency, rendering time, error rate, and user error. The proposed PDIE-VRT-SCGAN method attains 22.36%, 25.42% and 18.17% higher tracking accuracy, 21.26%, 15.42% and 19.27% higher latency, 28.36%, 25.32% and 28.27% higher frame rate compared with existing methods, such as design and implementation of virtual reality interactive product software depend on artificial intelligence deep learning algorithm(DVRI-PS-AI-DL), virtual evaluation system for product designing utilizing virtual reality (VES-PD-VR), and analysis of unsatisfying user experiences with unmet psychological needs for virtual reality exergames utilizing deep learning approach (AUUE-UP-VRE-DLA) respectively.

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Enciso López, Ervin Saúl, Efrain Isaias Camarin Sanchez, Daniela Vazquez Juarez, Alejandro Noguez-Ramos, Daniela Shveid Gerson, Benigno Rodriguez, Omar Serrano Villamayor i in. "Immunotherapy experience in malignant pleural mesothelioma in a single tertiary center." Journal of Clinical Oncology 39, nr 15_suppl (20.05.2021): e20565-e20565. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.e20565.

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e20565 Background: Malignant pleural mesothelioma (MPM) is a rare and aggressive cancer. Prognosis is generally poor, with a median overall survival (mOS) of approximately 12 months. MPM appears to be directly linked to immunosuppressive mechanisms, leading to use of checkpoint inhibitors for patients with this disease. Methods: We performed a retrospective chart review of patients with MPM at our institution between January 2015 to December 2020. All patients were over 18 years at the time of diagnosis of mesothelioma, a total of 8 patients were retrieved from the pathology database of The American British Cowdray Medical Center. The clinical-pathologic features collected were sex, age, performance status, risk factors, pTNM stage (AJCC 8th edition), histology type, sintomatology of onset, metastases sites and treatment. Clinical response rate and other outcomes were assessed. Descriptive statistics were used to describe a patient's demographic and disease characteristics. Results: 8 patients, aged 49 to 71 years (median of 65) at diagnosis of MPM were treated in our center. Both sex presented 4 patients in total. An identifiable risk factor was recorded in 4 patients (2 with asbesto exposure and 2 with heavy smoking). 7 patients (87.5%) had PS 0 or 1, the remaining has PS 2. The clinical stage at diagnosis was unresectable in 7 patients. 3 patients were assessed with PD-L1 expression (SP263 or 22C3), only one with expression of 20%. All patients received at least one scheme of chemotherapy prior to receiving immunotherapy, 25% received bevacizumab/platinum/anti-folate agents. Checkpoint inhibitors were introduced as a second line in 20% and in 80% has a third or more lines. Pembrolizumab was used in 20% and Nivolumab in 80%. The tumor responses with immunotherapy were as follows: partial response 12.5%, stable disease 75% and progressive disease 12.5%. Median progression-free survival of the first line treatment was 18.9 months (4.6-33.6 months), and for the line with checkpoint inhibitors was 11.2 weeks (7-21.2). In the full cohort, mOS was 37.0 months (95% CI:14.5-39.6). According to histology, the mOS for epithelioid-type was 36.6 months and for biphasic-type was 14.6 months (p = 0.42). mOS was 37.0 months for the group with immunotherapy and 15.0 months for those with standard chemotherapy (p = 0.14). The most frequently reported immune mediated adverse events were hypothyroidism and colitis (each one with one patient). Conclusions: In this real-world analysis, mOS was superior to those obtained in the MAPS2 trial (mOS 11.9 months), despite the fact that 80% of the population that received immunotherapy was in third or more lines. Limitations include limited numbers of patients, retrospective review, single institution, and inclusión of many heavily pretreated patients. Also molecular and immunohistochemical results such as PD-L1 status were only available on a limited number of patients.

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Lin, T., F. Xu, S. Wang, Y. He, W. Tian i Z. Guan. "Oxaliplatin/CF/5-FU versus paclitaxel/CF/5-FU in patients with advanced gastric cancer: A phase II clinical trial". Journal of Clinical Oncology 24, nr 18_suppl (20.06.2006): 14014. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.14014.

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14014 Background: Although many randomized trials of chemotherapy for advanced gastric cancer have been reported during the past two decades, no standard regimens worldwide have been established yet. Now Paclitaxel and Oxaliplatin have shown promising activity in advanced gastric cancer. We prospectively evaluated toxicity, efficacy and survival of Oxaliplatin /CF/5-FU versus Paclitaxel/CF/5-FU. Methods: Metastatic or locally advanced gastric cancer; performance status (PS) 0–2. Patients (pts) were enrolled and randomized into arm A with Oxaliplatin 100mg/m2, 5-FU 400 mg/m2 bolus, FA 200 mg/m2 2h, 5-FU 2500 mg/m2 46h, q2w or into arm B with Paclitaxel 80 mg/m2, 5-FU 400 mg/m2 bolus, FA 200 mg/m2 2h, 5-FU 2500 mg/m2 46h, q2w. Results: From 2000 to 2005, (A/B) 46/43 pts were enrolled into this study. Median age (52/50 y), gender, PS, localization and numbers of metastatic sites were comparable for both arms. Pts who were not chemotherapy naive in A/B (% of pts) were 41.3/33.3. All pts were eligible and evaluable for toxicity and response. Overall response (CR+PR) rate for A/B (% of pts): 37.0/47.2 (p<0.05), tumor control rate (CR+PR+SD) 76.1/69.4(p<0.05). Median time to progression (TTP) were for A/B: 6.0 and 3.2 months. And median survival time for A/B were 13.4 and 13.8 months. Grade 3/4 toxicities were for A/B (% of pts): neutropenia 10.9/5.6, thrombocytopenia 4.3/2.8, anemia 0/2.8, vomiting 8.7/2.8, neurotoxic 0/2. No treatment-related death occurred in A/B. Conclusions: Oxaliplatin /CF/5-FU and Paclitaxel/CF/5-FU are both effective and safe in advanced or metastatic gastric cancer. Though Oxaliplatin /CF/5-FU had better tumor control rate and median TTP, there was no difference between the arms in the median survival time. No significant financial relationships to disclose.

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Chikamori, Kenichi, Keisuke Aoe, Tadashi Maeda, Daizo Kishino, Keiji Oishi, Katsuyuki Hotta, Tsuneo Matsumoto i Hiroshi Ueoka. "Impact of concomitant use of anti-acid agents on efficacy of gefitinib in EGFR-mutant non-small-cell lung cancer (NSCLC)." Journal of Clinical Oncology 31, nr 15_suppl (20.05.2013): e19008-e19008. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.e19008.

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e19008 Background: Gefitinib, an EGFR-tyrosine kinase inhibitor, is an essential agent for EGFR-mutant NSCLC. The preclinical studies revealed its reduced area under the curve (AUC) by elevation of pH in GI tract, potentially leading to alteration in the absorption of gefitinib. It, however, has been controversial as to whether and how simultaneous use of anti-acid agents, commonly used in clinical practices, could alter the sensitivity of gefitinib, especially in EGFR-mutant NSCLC. Thus, we conducted a retrospective cohort study to clarify this issue. Methods: We evaluated progression-free survival (PFS) and overall survival (OS) from the medical charts of chemotherapy-naïve patients with EGFR-mutant NSCLC treated with gefitinib monotherapy in our institution. We also identified history of concomitant use of anti-acid agents (proton pomp inhibitors and histamine type 2 receptor blockers) at the time of initiation of gefitinib therapy and assessed its impact on the efficacy of gefitinib using Cox’s proportional hazard model. Results: Between 2006 and 2012, consecutive 83 patients received gefitinib therapy, of whom 29 (34.9%) used anti-acid agents simultaneously. Baseline clinical characteristics between the two groups (use and non-use of anti-acid agents) were well balanced except performance status (PS) of 0: 17.2% vs. 37.0% respectively. Neither PFS nor OS were influenced by concomitant use of anti-acid agents in univariate analysis (hazard ratio: 1.12; 95% confidence interval: 0.66-1.92 and 1.67; 0.86-3.44, respectively). Multivariate analysis also showed no significant effect of anti-acid agent use on PFS and OS (1.18; 0.67-2.06 and 1.66; 0.81-3.38, respectively), whilst poor PS affected OS (2.03; 1.27-3.26). Additionally, no difference in the impact of use of anti-acid agents on the gefitinib sensitivity was observed when stratified by the type of EGFR mutations. Conclusions: Concomitant use of anti-acid agents does not seem to affect efficacy of gefitinib in EGFR-mutant NSCLC. It is unlikely that physicians need to keep in mind the drug interaction of gefitinib and anti-acid agents in daily clinical practices, although further extensive cohort studies are warranted.

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Schill, Simone, Beatrix Stessl, Nadia Meier, Alexander Tichy, Martin Wagner i Martina Ludewig. "Microbiological Safety and Sensory Quality of Cultivated Mushrooms (Pleurotus eryngii, Pleurotus ostreatus and Lentinula edodes) at Retail Level and Post-Retail Storage". Foods 10, nr 4 (9.04.2021): 816. http://dx.doi.org/10.3390/foods10040816.

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In this study, the microbiological and sensory quality of cultivated mushrooms (Pleurotus ostreatus and eryngii and Lentinula edodes) available at the Austrian retail level were determined. Aerobic mesophilic bacteria (AMC), Enterobacteriaceae (EB), Pseudomonadaceae (PS), lactic acid bacteria (LAB), yeast, moulds and presumptive Bacillus cereus were enumerated at the day of purchase and after storage at 4 °C for 7 or 12 days. Additionally, the presence of Salmonella spp. and Listeria monocytogenes was investigated. Isolates of presumptive spoilage bacteria were confirmed by partial 16S rRNA sequencing. At the day of purchase, 71.2% of the samples were of high microbiological quality and grouped into the low contamination category (AMC < 5.0 log cfu/g), while the sensory quality of 67.1% was categorized as “very good or good”. After storage, the number of samples with high microbial quality was 46.6%, and only 37.0% of the samples scored as “very good or good”. The most abundant species across all mushroom samples were the Pseudomonas fluorescens species complex (58.4%) and the potential mushroom pathogen Ewingella americana (28.3%). All mushroom samples tested negative for Salmonella spp., L. monocytogenes and Bacillus cereus. The microbiological and sensory quality of the analysed mushrooms at the day of purchase and after storage was considered to be good overall. Longer transport distances were found to have a significant influence on the microbiological and sensory quality.

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Cortellini, Alessio, Alessandro Parisi, Katia Cannita, Luca Napoleoni, Paola Lanfiuti Baldi, Olga Venditti, Giampiero Porzio i Corrado Ficorella. "First-line chemotherapy with docetaxel, oxaliplatin, and timed-flat infusion 5Fluorouracil in metastatic gastro-esophageal adenocarcinomas: The experience with FD/FOx regimen." Journal of Clinical Oncology 36, nr 4_suppl (1.02.2018): 178. http://dx.doi.org/10.1200/jco.2018.36.4_suppl.178.

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178 Background: Triplet chemotherapies, with fluoropyrimidines, platin derivates and Docetaxel, represent an option for first line treatment of metastatic Gastro-Esophageal Adenocarcinoma (mGEA). To increase tolerability and dose intensity (DI), we previously developed an alternative way of administration of 5Fluorouracil (5FU), with nocturnal “timed-flat infusion” (TFI) (from 10:00 PM to 10:00 AM), without 5FU bolus and Folinic Acid, in several combination-schedules in breast and colorectal cancers. Methods: We report a retrospective analysis of 27 mGEA patients (pts) treated with FD/FOx regimen, a schedule of weekly TFI/5FU for two nights at 1000 or 900 mg/m2/night, associated to alternating Docetaxel at 50 mg/m2 on days 1 and 15, and Oxaliplatin at 80 mg/m2 on days 8 and 22, cycles repeated every 4 weeks. Results: From June 2007 to July 2017, 17 pts (62.9%) were treated with standard FD/FOx and 10 pts (37.1%) with modified FD/FOx (defined by any projected dose reduction compared to standard) due to age, PS and comorbidities. Median age was 60 years (range 41-80), male/female ratio 19/8, ECOG-PS 0, 7 (26%), 1, 16 (59%), 2, 4 (15%); 17 pts (62.9%) had a Cumulative Illness Rating Scale Intermediate stage, 1 patient (3.7%) a Secondary one. Thirteen pts (48%) had unresected primary tumor. ORR, median PFS and median OS were 73.9% (α0.05, CI±18), 13 and 16 months, respectively. The only G4 toxicity was neutropenia (11.1%); G3 were: neutropenia (29.6%), asthenia (22.2%), diarrhea (22.2%); most relevant G2 toxicities were: nausea (33.3%), anorexia (40.7%), neuropathy (37.0%) and anemia (40.7%). No febrile neutropenia was observed. The received (r)DI were 80% of standard full dose of each drug: Docetaxel 20 mg/m2/week, Oxaliplatin 32 mg/m2/week and 5FU 1440 mg/m2/week. Out of 21 pts who progressed to FD/FOx, 13 pts (48.1%) underwent a second line therapy (6 rechallenges with taxanes). Conclusions: Even if requires a careful management, FD/FOx is a feasible option for first line treatment of mGEA pts, particularly in needing of tumor shrinkage, with significant activity, high rDIs, and acceptable safety profile when compared to literature.

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Saiag, Philippe, Rafaele Molinier, Anissa Roger, Blandine Boru, Yves Otmezguine, Joelle Otz, Charles-Ambroise Valery i in. "Efficacy of Large Use of Combined Hypofractionated Radiotherapy in a Cohort of Anti-PD-1 Monotherapy-Treated Melanoma Patients". Cancers 14, nr 17 (23.08.2022): 4069. http://dx.doi.org/10.3390/cancers14174069.

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To assess the role of radiotherapy in anti-PD-1-treated melanoma patients, we studied retrospectively a cohort of 206 consecutive anti-PD-1 monotherapy-treated advanced melanoma patients (59% M1c/d, 50% ≥ 3 metastasis sites, 33% ECOG PS ≥ 1, 33% > 1st line, 32% elevated serum LDH) having widely (49%) received concurrent radiotherapy, with RECIST 1.1 evaluation of radiated and non-radiated lesions. Overall (OS) and progression-free (PFS) survivals were calculated using Kaplan–Meier. Radiotherapy was performed early (39 patients) or after 3 months (61 patients with confirmed anti-PD-1 failure). The first radiotherapy was hypofractionated extracranial radiotherapy to 1–2 targets (26 Gy-4 weekly sessions, 68 patients), intracranial radiosurgery (25 patients), or palliative. Globally, 67 (32.5% [95% CI: 26.1–38.9]) patients achieved complete response (CR), with 25 CR patients having been radiated. In patients failing anti-PD-1, PFS and OS from anti-PD-1 initiation were 16.8 [13.4–26.6] and 37.0 months [24.6–NA], respectively, in radiated patients, and 2.2 [1.5–2.6] and 4.3 months [2.6–7.1], respectively, in non-radiated patients (p < 0.001). Abscopal response was observed in 31.5% of evaluable patients who radiated late. No factors associated with response in radiated patients were found. No unusual adverse event was seen. High-dose radiotherapy may enhance CR rate above the 6–25% reported in anti-PD-1 monotherapy or ipilimumab + nivolumab combo studies in melanoma patients.

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Ducreux, Michel, Jean-François Seitz, Denis Smith, Dermot O'Toole, Céline Lepère, Laurence Bitoun i Emmanuel Mitry. "Efficacy and safety of bevacizumab combined with chemotherapy in the treatment of patients with metastatic well-differentiated duodeno-pancreatic endocrine tumors (BETTER study)." Journal of Clinical Oncology 30, nr 15_suppl (20.05.2012): 4036. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.4036.

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4036 Background: Gastrointestinal neuroendocrine tumors (NET) overexpress vascular endothelial growth factor (VEGF), thus we hypothesized that Bevacizumab (Bv), a monoclonal antibody targeting VEGF in combination with chemotherapy may show an activity in duodeno-pancreatic NET. Methods: This multicenter, open-label, non-randomized, two- group phase II trial assessed in one group the efficacy and safety of Bv (7.5 mg/kg IV on day 1, every 3 weeks), combined with 5-FU/streptozotocin (stz): 5-FU 400 mg/m²/d; Stz 500 mg/m²/d IV, d1-5/ every 42 days, during a minimum of 6 months in patients (pts) with progressive, metastatic, well-differentiated duodeno-pancreatic NET (WHO 2000), not previously treated with chemotherapy, ECOG PS ≤2 and Ki 67 index < 15%. Primary endpoint was progression-free survival (PFS). Secondary endpoints were overall survival (OS), response rate, safety and quality of life. Study duration was 24 months. Results: In the ITT population, 34 pts were enrolled, 22 (64.7%) were men, median age 55.3 years (37.0-77.6), 33 (97.1%) pts had ECOG-PS 0/1. Most metastases were in the liver 33 (97.1%) pts or lymph nodes 14 (41.2%) pts. Ki-67 proliferative index was 0-2% in 8 (25%) pts, 3-4% in 5 (15.6%), 5-9% in 6 (18.8%), 10-14% in 12 (37.5%) and 15% in 1(3.1%) pt. Median treatment duration was 14.0 months; median number of cycles was 10. At 24 months, median PFS was 23.7 months [95%CI: 14.5; not reached] based on 18 events. PFS rate at 18 months was 62%. Tumor control rate was 100% (n= 34) including partial response in 19 (55.9%) pts and stable disease in 15 (44.1%) pts. Survival rate at 24 months was 88%. Median OS was not reached, 5 patients died. CTC grade 3/4 Adverse Events (AEs) occurred in 23 (67.6%) of pts, mainly digestive 5 (14.7%) pts. G3/4 Bv targeted AEs were hypertension in 7 (20.6%) pts and thromboembolism in 4 (11.8%). Conclusions: Efficacy data in this phase II trial assessing a novel approach with Bv and 5-FU/stz in duodeno-pancreatic NET is encouraging and the toxicity profile is acceptable. Results suggest that Bv may have a place in the treatment of pancreatic NET and warrant further investigation in a phase III trial.

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Campanale, Claudia, Ilaria Savino, Carmine Massarelli i Vito Felice Uricchio. "Fourier Transform Infrared Spectroscopy to Assess the Degree of Alteration of Artificially Aged and Environmentally Weathered Microplastics". Polymers 15, nr 4 (11.02.2023): 911. http://dx.doi.org/10.3390/polym15040911.

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Fourier transform infrared (FTIR) is a spectroscopy technique widely used to identify organic materials. It has recently gained popularity in microplastic (MP) pollution research to determine the chemical composition of unknown plastic fragments. However, it could also be used to evaluate the degree of ageing of MPs collected from the environment. In this context, the principal aim of our research has been to qualitatively evaluate the natural weathering of environmental MPs collected in an Italian freshwater body (the Ofanto River) using ATR-FTIR technology. Furthermore, we compared environmental particles to weathered artificial MPs under controlled light and temperature conditions and to unaltered pristine materials to assess the results. FTIR spectra were acquired using a Nicolet Summit FTIR (ThermoFisher Scientific) equipped with an Everest ATR with a diamond Crystal plate and a DTGS KBr detector (wavenumber range 4000–500 cm−1, 32 scans per spectrum, spectral resolution of 4 cm−1). The degree of ageing was assessed using three different indexes known to be related to changes in MPs: Carbonyl Index (CI), Hydroxyl Index (HI), and Carbon-Oxygen Index (COI). The overall results showed that the regions reflecting changes (hydroxyl groups, peaks from 3100 to 3700 cm−1, alkenes or carbon double bonds, 1600 and 1680 cm−1, and carbonyl groups, 1690 and 1810 cm−1) appeared significantly modified in artificial and natural weathered particles compared to the pristine materials. The indexes calculated for polymers degraded under the artificial photo and thermo ageing conditions displayed a general tendency to increase with the time in contact with irradiation time. Particular enhancements of CI of PS fragment and PE pellet, HI of PE and PS fragments and PE pellet, and COI of PS fragment were observed. Otherwise, the following incubation of the same particles at a constant temperature of 45 °C did not further affect the chemical composition of the particles. Moreover, new unique peaks were also observed in the freshwater particles, almost all in the fingerprint region (1500–500 cm−1). Differences in CI, HI, and COI were evidenced among the different morphological MP shapes. On the one hand, the CI calculated for the environmental PE pellets showed values ranging from 0.05 to 0.26 with a mean value of 0.17 ± 0.10. Most samples (57%) presented a CI with values between 0.16 and 0.30. On the other hand, fragments presented slicer modifications in the carbonyl region with CI values lower than pellets (0.05 ± 0.05). This index helps evaluate the degradation of PE MPs by UV light, increasing with enhancing residence time in the environment. Conversely, fragments showed greater values of HI (5.90 ± 2.57) and COI (1.04 ± 0.48) than pellets, as well as lines, which presented the maximum value of HI (11.51). HI is attributed to the bond vibrations of hydroxyl, carboxyl, or phenol groups. In contrast, COI is frequently attributed to the vibrations of C_O bonds found in carbohydrates, alkanes, secondary alcohols, and ketones. In conclusion, our results showed characteristics spectra acquired from environmental particles compared to pristine and artificial aged ones. The interpretation of our main results emphasizes the need to conduct ecotoxicological experimental studies using naturally weathered particles due to the unicity of their properties, which are more helpful for understanding microplastic pollution effects.

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48

Altarturi, Maymouna, Kausar Suleman, Adhar AlSayed, Humaid Al-Shamsi, Aydah Alawadhi, Bassam Basuliamn i Sabah Alaklabi. "Abstract PO4-12-10: Sacituzumab Govitecan Toxicity Outcomes In Arab Patients with Metastatic Breast Cancer". Cancer Research 84, nr 9_Supplement (2.05.2024): PO4–12–10—PO4–12–10. http://dx.doi.org/10.1158/1538-7445.sabcs23-po4-12-10.

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Abstract Background: The Arab population is often underrepresented in clinical trials, which limits our knowledge of drug safety and efficacy in this population due to genetic variability that can affect drug metabolism and adverse events (AEs). Sacituzumab govitecan (SG) is approved for metastatic triple negative breast cancer (mTNBC), and recently hormone receptor positive metastatic breast cancer (HR+ MBC). Here we report toxicity outcomes and RDI in Arab population. Methods: A multi-center retrospective study of patients with mTNBC and HR+ MBC treated with SG from January 2021 until May 2023 was conducted. Demographics and clinical variables including site of metastases, prior lines of therapy, relative dose intensity (RDI), adverse events (AEs) were collected. For continuous variables, Mann-U Whitney and Kruskal Wallis tests were used to compare mean, median, standard deviation, and range. For categorical variables, Fisher's exact tests and Pearson Chi-square tests were used. SAS v9.4 was used to perform statistical analysis at a significance level of 0.05. Results: A total of 35 patients was enrolled. The median age at diagnosis of metastatic breast cancer was 39 years interquartile range (IQR) (35, 44). The median age at starting SG was 44.5 years IQR (38,50). The majority of patients (65%) had an Eastern Cooperative Oncology Group performance status (ECOG PS) of 1, (21%) of the patients had an ECOG PS of 0, and (15%) had an ECOG PS of 2. 48.6% received 3 or more lines of prior therapy in the metastatic setting while 51.4% received less than 3 lines of prior therapy in the metastatic setting. 77.1% of patients had 3 or > organs involved with metastatic disease, while 22.9% of patients had < 3 organ involved. The most common metastatic sites were the lung (54.3%), liver (62.9%), bone (68.6%), and brain (45.7%). The median RDI of SG was 100% for a sample of 34 individuals, with one missing value IQR (94%,100%). The rate of overall AEs was (77.1%), with the most common AEs being; neutropenia (44.4%), diarrhea (37.0%), anemia (22.2%), thrombocytopenia (22.2%), nausea (14.8%), and vomiting (7.4%). Garde 3 AEs rate was 34.3%. The most common grade 3 adverse events were diarrhea (11.4%), fatigue (5.7%), and alopecia (2.9%). The rate of treatment interruption and dose reduction due to AEs was 31.4%. Only one patient (2.9%) had to discontinue SG treatment due to adverse events. Conclusion: The study suggests that SG is safe and well-tolerated in young Arab patient population. The sample consisted of relatively young patients, which may reflect a reluctance to prescribe SG to older Arab patients. Caution should be exercised when generalizing the findings due to limitations of the study. Further studies with larger sample sizes are needed to validate these findings and to explore the efficacy of SG in Arab patients with mTNBC and HR+ MBC. Citation Format: Maymouna Altarturi, Kausar Suleman, Adhar AlSayed, Humaid Al-Shamsi, Aydah Alawadhi, Bassam Basuliamn, Sabah Alaklabi. Sacituzumab Govitecan Toxicity Outcomes In Arab Patients with Metastatic Breast Cancer [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO4-12-10.

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49

Winkler, Jeannine, Sabine Kroiss, Margaret L. Rand, Markus Schmugge i Oliver Speer. "Activation of Caspases-8 and -9 Occurs In Platelets From Children with Immune, but Not Chemotherapy-Related, Thrombocytopenia." Blood 116, nr 21 (19.11.2010): 3700. http://dx.doi.org/10.1182/blood.v116.21.3700.3700.

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Abstract Abstract 3700 Apoptotic-like processes in platelets are similar to those observed during apoptosis in the cytoplasm of nucleated cells: activation of caspase-8, caspase-9, and caspase-3, loss of mitochondrial inner membrane potential, and externalization of phosphatidylserine (PS) (Leytin et al, Br J Haematol 2006; Lopez et al, J Thromb Haemost 2009). We recently showed that platelets in pediatric primary immune thrombocytopenia (ITP) have activated caspase-3 (aCASP3) and externalized PS, both of which were reduced after IVIg administration (Speer et al, Blood 2008;112: 3417). To gain a more complete understanding of the apoptosis that occurs in ITP platelets, in the present study, we investigated whether caspase-8 and caspase-9 are also activated in platelets from children with ITP, and examined whether the increase in platelet count in response to IVIg is associated with a decrease in activated caspase-8 (aCASP8) and -9 (aCASP9) in platelets, as was observed for aCASP3. In addition, we measured the mitochondrial membrane potential in platelets before and after IVIg therapy. Children with primary ITP were enrolled in this prospective study. Severity of bleeding symptoms was assessed according to a pediatric bleeding score for ITP at the time of diagnosis. Blood samples were obtained at the time of diagnosis and after IVIg therapy for measurement of platelet count and for flow cytometric analyses of platelet apoptotic-like events. In citrated platelet-rich plasma, platelets were identified as CD42 positive events; aCASP8 and aCASP9 were measured as % platelets with bound FITC-fluorescent-labeled inhibitors of activated caspases; and mitochondrial membrane potential was measured as mean fluorescence intensity of the membrane potential sensitive fluorescent tetramethylrhodamine ethyl ester (TMRE). All patients (median age 5.4 yrs, n = 8) presented with typical symptoms of acute ITP with a bleeding score of 2 – 3 and had platelet counts < 20×109/L. Results from ITP patients were compared with 2 control groups, healthy children (platelet counts: 266–348 × 109/L, median age 6.8 yrs, n = 7) and children with thrombocytopenia as a result of chemotherapy for malignancies (cTP) (platelet counts: 3–51 × 109/L, median age 10.2 yrs, n = 7). ITP patients had significantly higher proportions of platelets with aCASP8 (17.5±5.1%) and aCASP9 (16.9±5.8%) compared with both healthy children (aCASP8 1.0±0.3%; aCASP9 1.1±0.3%) and children with cTP, (aCASP8 2.2±0.4%; aCASP9 1.9±0.4%) (p<0.01-0.05). In contrast, a loss of mitochondrial membrane potential was not observed in platelets from ITP patients at baseline, in healthy controls, or cTP. All ITP patients were treated with a maximum of 3 doses of IVIg (0.4 – 0.8 g/kg/dose) and showed a rise in platelet counts to > 20 × 109/L and amelioration of bleeding symptoms by 24 – 72 hours after IVIg administration. Concomitantly, the fractions of platelets with aCASP8 and aCASP9, decreased towards control values (ITP patients after IVIg: aCASP8 7.8±5.3%; aCASP9 6.9±2.1; p=0.5 for both compared to controls). Again no change in mitochondrial potential was observed after IVIg. In summary, we have demonstrated enhancement of the platelet apoptotic-like processes of aCASP8 and aCASP9 specifically in pediatric primary ITP, which were not observed in cTP. However, the platelet mitochondrial membrane potential was unchanged in ITP (before and after IVIg) and did not differ compared cTP and healthy children. Consistent with primary ITP, the patients' platelet counts were low and increased with IVIg administration. In parallel, IVIg led to a decrease of aCASP8 and aCASP9 in the patients' platelets. Together with our previously reported results (Speer et al, Blood 2008;112: 3417), we show that apoptotic events in platelets such as activation of caspases-8, -9, and -3 and PS exposure are increased specifically in ITP but not in cTP, and are decreased after IVIg treatment. As we detected no loss of the mitochondrial membrane potential in platelets from ITP patients, it may be that apoptotic processes in these platelets are not activated by mitochondrial signaling, but rather via an extrinsic signaling cascade including caspase-8, leading to the activation of caspase-3 and caspase-9. However, the complete signaling pathway leading to caspase-8 activation in platelets of pediatric ITP remains to be elucidated. Disclosures: No relevant conflicts of interest to declare.

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Nagai, Minako, Masayuki Sho, Takahiro Akahori, Kenji Nakagawa, Kota Nakamura, Tadataka Takagi, Toshihiro Tanaka, Hideyuki Nishiofuku, Kimihiko Kichikawa i Naoya Ikeda. "Effect of neoadjuvant chemoradiotherapy on prognosis in resectable and borderline resectable pancreatic cancer with venous involvement." Journal of Clinical Oncology 37, nr 4_suppl (1.02.2019): 343. http://dx.doi.org/10.1200/jco.2019.37.4_suppl.343.

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343 Background: The efficacy of neoadjuvant treatment for pancreatic cancer (PC) remains to be established. In this study, we have retrospectively evaluated the impact of neoadjuvant chemoradiothrapy (NACRT) on perioperative and long-term clinical outcome in PC. Methods: One hundred eighty one patients who preoperatively received full-dose gemcitabine (1000mg/m2) with concurrent radiation of 54 Gy between 2006 and 2017 were analyzed. One hundred forty nine patients who proposed upfront surgery were served as control. Results: Among the 181 patients treated with NACRT, 23 (13%) couldn’t undergo pancreatic resection after NACRT because of distant metastasis in 10, tumor progression in 7 and poor PS in 6. While among the 149 patients who proposed upfront surgery, 10 (7%) couldn’t undergo pancreatic resection at laparotomy, because of distant metastasis in 8 and tumor progression in 2. In overall survival analysis of all patients with resected and unresected tumor, patients treated with NACRT had a better prognosis than those without (median survival time: 37.0 vs. 27.1M, P = 0.049). According to tumor resectability status including R (resectable), BR-P (borderline resectable with venous involvement) and BR-A (borderline resectable with arterial involvement) PC, in the R and BR-P group, overall survival was significantly better in the patients with NACRT (45.7 vs. 33.8M, P = 0.049, 61.7 vs. 14.6M, P = 0.002). Also only for resected tumors, patients treated with NACRT had a better prognosis than those without in the R and BR-P group (53 vs. 36.5M, P = 0.033, 61.7 vs. 14.6M, P = 0.002), while NACRT had no significant impact on prognosis in the BR-A group. The rate of pancreatic fistula, delayed gastric emptying and abdominal abscess were lower in the NACRT group than the control group. Furthermore, the lymph node metastasis rate, R0 resection rate and pathological stage were favorable in the NACRT group (P < 0.001, P = 0.005, P < 0.001). The completion rate of adjuvant chemotherapy was also higher in the NACRT group (P = 0.001). Conclusions: NACRT had a variety of favorable impact in PC treatment. In particular, it significantly improved the prognosis in the R and BR-P, but not BR-A.

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