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Artykuły w czasopismach na temat "Protein Model Discrimination"

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Adkar, Bharat V., Arti Tripathi, Anusmita Sahoo, et al. "Protein Model Discrimination Using Mutational Sensitivity Derived from Deep Sequencing." Structure 20, no. 2 (2012): 371–81. http://dx.doi.org/10.1016/j.str.2011.11.021.

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Khare, Shruti, Kritika Gupta, and Arti Tripathi. "Mutant Phenotype Prediction and Protein Model Discrimination using Deep Sequencing Data." Biophysical Journal 114, no. 3 (2018): 199a. http://dx.doi.org/10.1016/j.bpj.2017.11.1116.

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Khare, Shruti, Munmun Bhasin, Anusmita Sahoo, and Raghavan Varadarajan. "Protein model discrimination attempts using mutational sensitivity, predicted secondary structure, and model quality information." Proteins: Structure, Function, and Bioinformatics 87, no. 4 (2019): 326–36. http://dx.doi.org/10.1002/prot.25654.

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Bernacki, Joseph P., and Regina M. Murphy. "Model Discrimination and Mechanistic Interpretation of Kinetic Data in Protein Aggregation Studies." Biophysical Journal 96, no. 7 (2009): 2871–87. http://dx.doi.org/10.1016/j.bpj.2008.12.3903.

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Kirven, Sydney, Heather Farmer, and Amy Thierry. "Perceived Everyday Discrimination and C- Reactive Protein Influence on Cognition of Older Black Adults." Innovation in Aging 5, Supplement_1 (2021): 1040. http://dx.doi.org/10.1093/geroni/igab046.3718.

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Abstract Black adults and women are more likely to experience serious cognitive decline in older age than their white and male counterparts. Evidence suggests perceived discrimination is associated with poor cognition in older adults, though the mechanisms remain unclear. Perceived discrimination has been linked to elevated inflammatory markers, such as C-reactive protein (CRP), which increases risk for worse cognitive functioning. Yet, little research has investigated whether CRP is implicated in the association between discrimination and cognition among Black older adults or if this relation
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Safo, Sandra, Lillian Haine, Jason Baker, et al. "89976 ASSESSING PROTEIN BIOMARKERS ROLE IN CVD RISK PREDICTION IN PERSONS LIVING WITH HIV (PWH)." Journal of Clinical and Translational Science 5, s1 (2021): 47–48. http://dx.doi.org/10.1017/cts.2021.526.

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ABSTRACT IMPACT: Our findings could potentially identify CVD at-risk persons living with HIV who might benefit from aggressive risk-reduction. OBJECTIVES/GOALS: PWH have higher rates of CVD than the general population yet CVD risk prediction models rely on traditional risk factors and fail to capture the heterogeneity of CVD risk in PWH. Here we identify protein biomarkers that are able to discriminate between CVD cases and controls in PWH, and we assess their added benefit beyond traditional risk factors. METHODS/STUDY POPULATION: We analyzed 459 baseline protein expression levels from five O
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Yanagisawa, Kiyoshi, Shuta Tomida, Keitaro Matsuo, et al. "Seven-Signal Proteomic Signature for Detection of Operable Pancreatic Ductal Adenocarcinoma and Their Discrimination from Autoimmune Pancreatitis." International Journal of Proteomics 2012 (May 14, 2012): 1–11. http://dx.doi.org/10.1155/2012/510397.

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There is urgent need for biomarkers that provide early detection of pancreatic ductal adenocarcinoma (PDAC) as well as discrimination of autoimmune pancreatitis, as current clinical approaches are not suitably accurate for precise diagnosis. We used mass spectrometry to analyze protein profiles of more than 300 plasma specimens obtained from PDAC, noncancerous pancreatic diseases including autoimmune pancreatitis patients and healthy subjects. We obtained 1063 proteomic signals from 160 plasma samples in the training cohort. A proteomic signature consisting of 7 mass spectrometry signals was u
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Wang, Cong, Yabing Hai, Xiaoqing Liu, et al. "Prediction of High-Risk Types of Human Papillomaviruses Using Statistical Model of Protein “Sequence Space”." Computational and Mathematical Methods in Medicine 2015 (2015): 1–9. http://dx.doi.org/10.1155/2015/756345.

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Discrimination of high-risk types of human papillomaviruses plays an important role in the diagnosis and remedy of cervical cancer. Recently, several computational methods have been proposed based on protein sequence-based and structure-based information, but the information of their related proteins has not been used until now. In this paper, we proposed using protein “sequence space” to explore this information and used it to predict high-risk types of HPVs. The proposed method was tested on 68 samples with known HPV types and 4 samples without HPV types and further compared with the availab
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Lowry, Troy W., Aubrey E. Kusi-Appiah, Debra Ann Fadool, and Steven Lenhert. "Odor Discrimination by Lipid Membranes." Membranes 13, no. 2 (2023): 151. http://dx.doi.org/10.3390/membranes13020151.

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Odor detection and discrimination in mammals is known to be initiated by membrane-bound G-protein-coupled receptors (GPCRs). The role that the lipid membrane may play in odor discrimination, however, is less well understood. Here, we used model membrane systems to test the hypothesis that phospholipid bilayer membranes may be capable of odor discrimination. The effect of S-carvone, R-carvone, and racemic lilial on the model membrane systems was investigated. The odorants were found to affect the fluidity of supported lipid bilayers as measured by fluorescence recovery after photobleaching (FRA
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Tang, Hua, Ren-Zhi Cao, Wen Wang, Tie-Shan Liu, Li-Ming Wang, and Chun-Mei He. "A two-step discriminated method to identify thermophilic proteins." International Journal of Biomathematics 10, no. 04 (2017): 1750050. http://dx.doi.org/10.1142/s1793524517500504.

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Improving thermostability of an enzyme can accelerate the relevant chemical reaction. Thus, the analysis and prediction of thermophilic proteins are conducive to protein engineering and enzyme design. In this study, a novel method based on two-step discrimination was proposed to distinguish between thermophilic and non-thermophilic proteins. The model was rigorously benchmarked on an objective dataset including 915 thermophilic proteins and 793 non-thermophilic proteins. Results showed that the overall accuracy of our method is 94.44% in 5-fold cross-validation, which is higher than those of o
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Rozprawy doktorskie na temat "Protein Model Discrimination"

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Saleem, Saira. "Proteomic profiling of pro and active matrix metalloproteinases using tandem mass spectrometry. optimization of affinity chromatography and nHPLC-MALDI-MS/MS for proteomic discrimination of matrix metalloproteinases in pre-clinical cancer model." Thesis, University of Bradford, 2012. http://hdl.handle.net/10454/5752.

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Matrix metalloproteinases (MMPs) network with other biological molecules to maintain the extracellular matrix (ECM) in normal physiology and perform different roles. Understanding and assigning specific role to each of 24 members of these endoproteinases is impeded because of lack of specific and efficient detection methods in biological samples. Moreover, MMP-based anti-cancer drug development has also been challenged because, currently, there is no robust methodology to distinguish the inactive pro-enzymes, active enzymes or those complexed with endogenous inhibitors in biological specimens.
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Khare, Shruti. "Protein Structure and Mutant Phenotype Prediction from Analysis of Mutant Libraries by Deep Sequencing." Thesis, 2017. http://etd.iisc.ac.in/handle/2005/4271.

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Proteins play a central role in all the biological processes. The immense diversity in protein structures and functions despite similar underlying composition is intriguing. The work presented in this thesis aims to provide a deeper understanding of protein structure-function relationships. It describes some techniques that were developed in order to probe these relationships. Chapter 1 provides a general introduction to the topics discussed in the thesis. Chapter 2 focuses on an important aspect of protein structures, the cavities. Although proteins are composed of regular arrangements of sec
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Części książek na temat "Protein Model Discrimination"

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Argren, Rigmor, Marco Evola, Thomas Giegerich, and Ivana Krstić. "The Evolving Recognition of Gender in International and European Law." In Gender-Competent Legal Education. Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-14360-1_8.

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AbstractThis chapter explains the development of international and European law from a gender perspective and describes how the process from a gender-neutral to a gender-sensitive approach was developed.Since 1945 and the adoption of the UN Charter, the idea of achieving greater gender equality was merged into many international documents, including the first catalog of women’s rights—Convention on the Elimination of all Forms of Discrimination against Women. Many principal and subsidiary bodies were established, contributing to the elimination of gender discrimination and to awareness-raising on some critical issues which were an impediment to achieving gender equality. Twenty years ago, UN Security Council Resolution 1325 was adopted, due to a global effort to establish a platform as a foundation to national and international policies to ensure greater protection of women and girls, during and after, armed conflicts. International Humanitarian Law, enshrined in the Geneva Conventions, also has rules that specifically seek to protect women during armed conflicts. Also, International Criminal Law has been developed to recognize extreme forms of sexual violence as international crimes.On the European level, under the auspices of the Council of Europe, several international conventions were adopted to achieve gender equality. One of the main instruments, the European Convention on Human Rights, provides broad protection from discrimination based on gender, established in a comprehensive jurisprudence of the European Court of Human Rights. The EU has a set of primary and secondary sources on anti-discrimination, which provides comprehensive protection from gender discrimination and serves as an inspiring model to States candidates and other European countries.
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Padrón, Thais Guerrero, Ljubinka Kovačević, and Mª Isabel Ribes Moreno. "Labour Law and Gender." In Gender-Competent Legal Education. Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-14360-1_17.

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AbstractThe chapter presents an overview of key labour law institutions, aiming at discussing the importance of the gender perspective in labour law. Therefore, the introductory section of the chapter will put this issue into the context of historical and conceptual framework genesis of regulating employment relationships. These issues are connected with the legal subordination and economic dependence of employees, which produce the need to create and implement norms that protect employees, as a weaker party to the employment relationship. This includes the limitation of employers’ (managerial, normative and disciplinary) prerogatives, in order to create the conditions for effective enjoyment of the right of jobseekers and employees for protection against gender-based discrimination. The labour law is, in this regard, traditionally conceived according to the model of a male worker, who is employed on the basis of a standard employment contract (open-ended full time employment contract). This then results in a failure to recognise or provide sufficient consideration of the specific needs that women have as participants in the labour market. The use of the feminist method, which included the understanding of gender as an analytical category in the field of labour law, opened up a new set of labour law issues. For example, in easing the ban on women working in physically demanding jobs, and the conceptualisation of the need to reconcile the professional and family duties of employees.. On the other hand, contemporary labour law, when creating conditions for achieving gender equality, is aimed primarily at women’s empowerment in the world of work. Persisting with this approach can lead to an oversimplified understanding of the principle of gender equality, ignoring the special needs of men in the world of work, as well as ignoring the importance of their role for consistent implementation of the principle of gender equality and women’s empowerment. The second section of the chapter will provide analysis of gender-based discrimination during the hiring process. Other sections will cover the risk of gender-based discrimination regarding rights, obligations and duties deriving from employment relationship, labour law measures to encourage improvements in the occupational safety and health, work-life balance for parents and caregivers, sexual harassment at work and promotion of gender equality in collective labour law.
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Olson, John S., and Abhik Ghosh. "Mammalian Myoglobin as a Model for Understanding Ligand Affinities and Discrimination in Heme Proteins." In The Smallest Biomolecules: Diatomics and their Interactions with Heme Proteins. Elsevier, 2008. http://dx.doi.org/10.1016/b978-044452839-1.50002-4.

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Slobozhenko, R. A., and Y. Y. Melnyk. "SECTION #5. LANGUAGE PICTURE OF THE WORLD: LINGUISTIC AND CULTURAL ASPECTS 5.2 THE PROBLEM OF ACCENT DISCRIMINATION IN GREAT BRITAIN AND FRANCE." In CURRENT THEORY AND PRACTICE ASPECTS OF LINGUISTICS, SOCIOLINGUISTICS AND METHODOLOGY OF FOREIGN LANGUAGES AT UNIVERSITIES IN MODERN GLOBAL HIGHER EDUCATIONAL SPACE. RS Global Sp. z O.O., 2022. http://dx.doi.org/10.31435/rsglobal/052-11.

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The article deals with the issue of accent discrimination – the focus on prejudice against regional accents. It has been noted that lack of regional lexicon is one of the main reasons as to why ‘accentism’ is still going strong. It has been articulated that the reasons for glottophobia are hegemony of the monolingualism in France and class divisions in Britain that can lead to a skewed view of the world. Examples of accent bias are given. It has been found that there is currently no legislation to protect someone from accent discrimination. It has been studied that ‘Received Pronunciation’ or the ‘Queen’s English’ in Britain and standardized French in France seem to sound ‘very intelligent’ and it is a wide held view. It is being identified that academic institutions still support the idea of a single language model and accent prejudice. It has been concluded that in multicultural and multilingual Britain and France the solution is reasonable accommodation. It is required that the speaker is to make themselves understood whatever accent they choose.
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Locke, Richard M. "Deliberation and University Governance." In Ideas That Matter. Oxford University Press, 2019. http://dx.doi.org/10.1093/oso/9780190904951.003.0006.

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In the United States, historical oppression and discrimination have barred certain groups based on their gender, race, religion, sexuality, and socioeconomic class from full participation in higher education. While there has been a long history of protest and pressure to diversify, progress has been mixed. After a recent wave of protests at Brown University, Richard M. Locke faced the task of developing a realistic and coherent university plan for addressing concerns and demands. Implementing insights from Joshua Cohen’s work on deliberation, Locke led a process that resulted in one of the most ambitious university diversity and inclusion action plans in the country. In this chapter, Locke describes the process undertaken and seeks to generalize from the experience at Brown to argue that collective deliberation can be an effective model for how universities can address an array of complex issues faced today.
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Hinnershitz, Stephanie. "Post-1965 Changes in Asian America." In A Different Shade of Justice. University of North Carolina Press, 2017. http://dx.doi.org/10.5149/northcarolina/9781469633695.003.0005.

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After World War II and through the 1960s, Asian Americans began a transformative process, from being the “yellow peril” to becoming the model minority, and Asian Americans in the South experienced, to some degree, the same transformation. The war and its mottos of fighting for freedom and democracy at home and abroad affected the way Americans viewed their own hypocrisy toward minorities in the United States. African Americans were the largest minority group to use the aims of the war to demand attention to their plight with Jim Crow, prompting the growth of a nationwide civil rights movement, but Americans also came to view the century-old forms of legal discrimination against Asian immigrants and Asian Americans in a new light. Not only did Congress repeal the Chinese Exclusion Act in 1943 (making it legal for some Chinese to naturalize and allowing a small number of Chinese immigrants to enter the United States), but Filipino Americans and Indian Americans received similar treatment during and after World War II. In 1952, the McCarran-Walter Act (or the Immigration and Nationality Act of 1952), although designed to protect American security during the early Cold War by prohibiting and deporting subversive aliens, also made it possible for Asian immigrants of all ethnicities to become American citizens (while the number of Asians admitted to the United States did not drastically increase). Americans also viewed the ability of Japanese Americans to overcome the massive civil rights violations of wartime imprisonment and achieve economic and educational success as a model for all minorities to follow. Asian Americans came through the fires of World War II and proved that they were loyal Americans and deserving of equal treatment and respect, and while more subtle and sometimes not so subtle forms of racism and discrimination ...
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Power, Maria. "‘A serious moral question to be properly understood’:1 Catholic human rights discourse in Northern Ireland in the 1980s." In Theories of International Relations and Northern Ireland. Manchester University Press, 2017. http://dx.doi.org/10.7228/manchester/9781784995287.003.0008.

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Liberal scholars have historically stressed the role of NGOs, including churches, in world politics. Recently, scholars have also stressed the normative influence of religious actors as agents in international relations. The seventh chapter examines the role of the Catholic Church in the Northern Ireland peace process by analysing the theological basis of Catholic attitudes and beliefs regarding peace and the manifestations of these teachings as applied by bishops in Northern Ireland. The chapter demonstrates that faith creates action and explains how an important religious tradition in Northern Ireland promoted peace by recognizing and responding to the new kind of wars and political conflicts that have emerged in recent decades. As the nature of conflict changed from a state-centred model into one which saw civil wars and ethnic-conflict becoming the norm, so too did Catholic responses; national Churches began to realise that protest and non-violent action was no longer enough to create a more peaceful world. Consequently, the Catholic hierarchy in Northern Ireland sought to achieve peace by working for justice, especially for political prisoners and those who suffered discrimination.
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Streszczenia konferencji na temat "Protein Model Discrimination"

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Samarawickrama, O., R. Jayatillake, and D. Amaratunga. "Identifying Proteins Associated with Disease Severity." In SLIIT INTERNATIONAL CONFERENCE ON ADVANCEMENTS IN SCIENCES AND HUMANITIES [SICASH]. Faculty of Humanities and Sciences, SLIIT, 2022. http://dx.doi.org/10.54389/eegc3170.

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Proteomic studies or studies of protein expression levels are growing swiftly with the steady improvement in technology and knowledge on understanding various anomalies affecting humans. Since differentially expressed proteins have an influence on overall cell functionality, this improves discrimination between healthy and diseased states. Identifying prime proteins offers prospective insights for developing optimized and targeted treatment methods. This research involves analyzing data from an early-stage study whose main purpose was to identify differentially expressed proteins. The presence
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Zhou, Deyu, and Yulan He. "Extracting protein-protein interaction based on discriminative training of the hidden vector state model." In the Workshop. Association for Computational Linguistics, 2008. http://dx.doi.org/10.3115/1572306.1572328.

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Ghazikhani, Hamed, and Gregory Butler. "TooT-BERT-C: A study on discriminating ion channels from membrane proteins based on the primary sequence’s contextual representation from BERT models." In ICBRA 2022: 2022 9th International Conference on Bioinformatics Research and Applications. ACM, 2022. http://dx.doi.org/10.1145/3569192.3569196.

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