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Rozprawy doktorskie na temat „Protein Based Molecular Diseases”

Autor: Grafiati

Data publikacji: 7 września 2023

Data aktualizacji: 31 lipca 2025

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1

Kumari, Vandana. "Structure-Based Computer Aided Drug Design and Analysis for Different Disease Targets." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1311612599.

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2

Dickerson, Matthew Thomas. "PROTEIN BASED BIOMIMETIC APPROACHS TO SURFACE HEMOCOMPATIBILITY AND BIOCOMPATIBILITY ENHANCEMENT." UKnowledge, 2012. http://uknowledge.uky.edu/cme_etds/6.

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T. pallidum can survive a primary immune response and continue growing in the host for an extended period of time. T. pallidum is thought to bind serum fibronectin (FN) through Tp0483 on the surface to obscure antigens. A Tp0483 fragment (rTp0483) was adsorbed onto functionalized self-assembled monolayers (SAMs) with FN. FN capture by adsorbed rTp0483 depended greatly on surface chemistry with COO- groups being best for FN binding. Hemocompatibility was determined by analysis of plasma protein adsorption, intrinsic pathway activation, and platelet activation. rTp0483+FN bound an equal or lesse

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3

Drobin, Kimi. "Antibody-based bead arrays for high-throughput protein profiling in human plasma and serum." Licentiate thesis, KTH, Proteinvetenskap, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-225980.

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Affinity-based proteomics utilizes affinity binders to detect target proteins in a large-scale manner. This thesis describes a high-throughput method, which enables the search for biomarker candidates in human plasma and serum. A highly multiplexed antibody-based suspension bead array is created by coupling antibodies generated in the Human Protein Atlas project to color-coded beads. The beads are combined for parallel analysis of up to 384 analytes in patient and control samples. This provides data to compare protein levels from the different groups. In paper I osteoporosis patients are compa

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4

Liu, Jiyun. "Structure based design of inhibitors toward disease related multivalent protein targets /." Thesis, Connect to this title online; UW restricted, 2006. http://hdl.handle.net/1773/8482.

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5

Freer, Rosie. "Molecular origins of tissue vulnerability to aberrant aggregation in protein misfolding diseases." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/275420.

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Neurodegenerative disorders, including Alzheimer’s disease (AD) and Parkinson’s disease (PD), are increasingly common in our ageing society, are remain incurable. A major obstacle encountered by researchers in their attempts to find effective therapies is represented by the current lack of understanding of the molecular origins of these disorders. It is becoming clear that, although the aggregation of specific proteins, including amyloid β (Aβ) and tau in AD and α-synuclein in PD, hallmark these disorders, such behaviour is a consequence of a wider, system-level disruption of protein homeostas

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6

Lewandowski, Eric Michael. "Structure Based Drug Design Targeting Bacterial Antibiotic Resistance and Alzheimer's Disease." Scholar Commons, 2015. http://scholarcommons.usf.edu/etd/5982.

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Structure based drug design is a rapidly advancing discipline that examines how protein targets structurally interact with small molecules, or known inhibitors, and then uses this information to lead inhibitor optimization efforts. In the case of novel inhibitors, protein structural information is first obtained via X-ray crystallography, NMR studies, or a combination of both approaches. Then, computational molecular docking is often used to screen, in silico, millions of small molecules and calculate the potential interactions they may have with the target protein’s binding pocket, in hopes o

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7

Hilbert, Brendan J. "Structure-based Targeting of Transcriptional Regulatory Complexes Implicated in Human Disease: A Dissertation." eScholarship@UMMS, 2013. https://escholarship.umassmed.edu/gsbs_diss/681.

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Transcriptional regulatory complexes control gene expression patterns and permit cellular responses to stimuli. Deregulation of complex components upsets target gene expression and can lead to disease. This dissertation examines proteins involved in two distinct regulatory complexes: C-terminal binding protein (CtBP) 1 and 2, and Interferon Regulatory Factors (IRF) 3 and 5. Although critical in developmental processes and injury response, CtBP transcriptional repression of cell adhesion proteins, pro-apoptotic factors, and tumor suppressors has been linked to the pathogenesis of multiple forms

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8

Hilbert, Brendan J. "Structure-based Targeting of Transcriptional Regulatory Complexes Implicated in Human Disease: A Dissertation." eScholarship@UMMS, 2007. http://escholarship.umassmed.edu/gsbs_diss/681.

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Transcriptional regulatory complexes control gene expression patterns and permit cellular responses to stimuli. Deregulation of complex components upsets target gene expression and can lead to disease. This dissertation examines proteins involved in two distinct regulatory complexes: C-terminal binding protein (CtBP) 1 and 2, and Interferon Regulatory Factors (IRF) 3 and 5. Although critical in developmental processes and injury response, CtBP transcriptional repression of cell adhesion proteins, pro-apoptotic factors, and tumor suppressors has been linked to the pathogenesis of multiple forms

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9

Lau, Kin-chong, and 劉健莊. "Microarray-based investigations of genetic diseases." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B45894760.

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10

Hall, David. "An XML-based Database of Molecular Pathways." Thesis, Linköping University, Department of Computer and Information Science, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-3717.

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<p>Research of protein-protein interactions produce vast quantities of data and there exists a large number of databases with data from this research. Many of these databases offers the data for download on the web in a number of different formats, many of them XML-based.</p><p>With the arrival of these XML-based formats, and especially the standardized formats such as PSI-MI, SBML and BioPAX, there is a need for searching in data represented in XML. We wanted to investigate the capabilities of XML query tools when it comes to searching in this data. Due to the large datasets we concentrated o

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11

Awan, Waqas Ahmed. "Structure-based characterisation and prediction of protein molecular function." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.613923.

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12

Crane, Peter. "Protein based molecular probes by unnatural amino acid incorporation." Thesis, University of Oxford, 2018. http://ora.ox.ac.uk/objects/uuid:772076fc-00f2-4ca7-bfa9-3da1ce7093cb.

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The "tag & modify" strategy for protein modification relies upon the genetic incorporation of an uncommon or unnatural amino acid into a protein backbone, followed by a chemo-selective modification to yield differentially modified proteins. This thesis describes the creation of a protein-based glycoconjugate tool for interrogating biological function. In Chapter 2, the unnatural amino acid, azidohomoalanine was genetically incorporated into a library of distance defined Np276 proteins via a selective pressure incorporation. Methods to prevent the common post translational modification N-termin

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13

Fortun, Jenny. "Protein aggregation in peripheral myelin protein 22 (pmp22)-associated neuropathies." [Gainesville, Fla.] : University of Florida, 2005. http://purl.fcla.edu/fcla/etd/UFE0010065.

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Thesis (Ph.D.)--University of Florida, 2005.<br>Typescript. Title from title page of source document. Document formatted into pages; contains 123 pages. Includes Vita. Includes bibliographical references.

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14

Shames, Igor. "Phenotypic differences between Peripheral Myelin Protein-22 (PMP-22) and Protein Zero (PO) mutations associated with Charcot-Marie-Tooth related diseases." Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=79122.

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Many hereditary peripheral neuropathies are characterized by abnormal myelination in peripheral nerves. Two structural myelin proteins, PMP22, a polytopic myelin protein, and P0, an Ig-like transmembrane protein, play a major role in myelin formation. A large number of mutations have been identified in P0 and PMP22 genes. Neuropathies associated with PMP22 and P0 mutations have varying severities suggesting their effects are pleiotropic. It is of great importance to explore molecular pathogenesis of mutated P0 and PMP22 proteins in order to understand the basic process of myelination an

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15

Raut, Nilesh G. "BIOSENSING SYSTEMS FOR THE DETECTION OF BACTERIAL QUORUM SENSING MOLECULES: A TOOL FOR INVESTIGATING BACTERIA-RELATED DISORDERS AND FOOD SPOILAGE PREVENTION." UKnowledge, 2012. http://uknowledge.uky.edu/chemistry_etds/13.

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Quorum sensing enables bacteria to communicate with bacteria of the same or different species, and to modulate their behavior in a cell-density dependent manner. Communication occurs by means of small quorum sensing signaling molecules (QSMs) whose concentration is proportional to the population size. When a QSM threshold concentration is reached, certain genes are expressed, thus allowing control of several processes, such as, virulence factor production, antibiotic production, and biofilm formation. Not only many pathogenic bacteria are known to produce QSMs, but also QSMs have been identifi

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16

Mohamed, Nahla. "Molecular Diagnosis of Common Viral Infectious Diseases Based on Real-Time PCR." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7118.

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17

Xu, Jiru. "Application of PCR and DNA sequencing based molecular diagnosis in infectious diseases." Thesis, University of Ulster, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.399727.

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18

Sorarù, Antonio. "Molecular and nanodimensional metal based systems for the therapy against neurodegenerative diseases." Doctoral thesis, Università degli studi di Padova, 2015. http://hdl.handle.net/11577/3424628.

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Reactive oxygen species (ROS) are harmful species produced during metabolic processes, such as photosynthesis and respiration, of living organism. In both case, the substrate (oxygen/water) undergoes several multi electronic reaction, during which some electrons can “escape” from the catalytic cycle and produce ROS, such as superoxide radical anion, hydrogen peroxide, hydroxyl radical and other derivatives. These species are really dangerous, since they are able to oxidize almost all cellular components. Indeed they can damage lipids, proteins, DNA, affecting cellular functions till cell deat

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19

Yang, Hui. "Theoretical Studies of Molecular Recognition in Protein-Ligand and Protein-Protein Complexes." University of Toledo / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1282339026.

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20

Xue, Chunyi, and 薛春宜. "Molecular characterization of infectious bursal disease virus (IBDV) receptor." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B31246187.

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21

Peters, Theodore Walter. "Investigating the relationship between protein aggregates and cellular dysfunction in polyglutamine disease /." Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2008.

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Thesis (Ph.D. in Biochemistry) -- University of Colorado Denver, 2008.<br>Typescript. Includes bibliographical references (leaves 128-144). Free to UCD affiliates. Online version available via ProQuest Digital Dissertations;

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22

Hosseini, Azade S. "Developing Peptide-Based Receptors to Study Molecular Recognition in Water." Thesis, Boston College, 2016. http://hdl.handle.net/2345/bc-ir:107218.

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Thesis advisor: Jianmin Gao<br>My graduate research career has focused on studying the principles that underlie molecular recognition, which include protein folding, protein-membrane interactions, structural preoranization for target binding and non-covalent interactions. This thesis will present an overview of this work through three different projects. I) Synthetic receptors for target binding in water. Molecular interactions in water provide the foundation for life. More specifically, the interactions between one or more molecules, through hydrogen bonding, π-effects, hydrophobic interactio

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23

Holler, Christopher J. "THE CELLULAR NUCLEIC ACID BINDING PROTEIN REGULATES THE ALZHEIMER’S DISEASE β-SECRETASE PROTEIN BACE1". UKnowledge, 2012. http://uknowledge.uky.edu/biochem_etds/12.

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Alzheimer’s disease (AD) is the most common neurodegenerative disease affecting the elderly population and is believed to be caused by the overproduction and accumulation of the toxic amyloid beta (Aβ) peptide in the brain. Aβ is produced by two separate enzymatic cleavage events of the larger membrane bound amyloid precursor protein, APP. The first, and rate-limiting, cleavage event is made by beta-secretase, or BACE1, and is thus an attractive therapeutic target. Our lab, as well as many others, has shown that BACE1 protein and activity are increased in late-stage sporadic AD. We have extend

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24

Ennen, Franka. "Protein-Glycopolymer Biohybrid Structures Based on Molecular Recognition Processes for Biomedical Applications." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-158789.

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The design of versatile biohybrid nanosized materials has revealed itself as a promising avenue towards biomedical applications in today´s life sciences. In this regard the combination of components of synthetic and natural origin facilitates an applicability which is supposed to be far beyond the sum of their single components. These biohybrid structures (BHS) can be built by a huge variety of building blocks including solid or soft nanoparticles, peptides/proteins, polynucleotides or low molecular weight drugs. Along with the latter the attachment of biologically active entities or imaging m

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25

Degani, G. "MOLECULAR CHARACTERIZATION OF MEMBRANE-BOUND GLYCOPROTEINS INVOLVED IN HUMAN DISEASES AND POTENTIAL TARGETS FOR NEW THERAPIES." Doctoral thesis, Università degli Studi di Milano, 2015. http://hdl.handle.net/2434/274187.

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The present thesis is focused on the molecular characterization of two eukaryotic membrane glycoproteins that are promising candidates for new therapeutic approaches to human diseases. The first glycoprotein is the human Receptor for the Advanced Glycation End products (hRAGE), a member of the immunoglobulin superfamily. RAGE is a type I transmembrane glycoprotein that is beneficial in normal physiological conditions but it is also a key player in the etiology and progression of several chronic pathologies such as neurodegenerative disorders (Alzheimer), atherosclerosis, cancer and complicat

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26

Vijayaraghavan, Jagamya. "MOLECULAR AND MACRO-MOLECULAR CYCLIZATION: STRUCTURE BASED DRUG DESIGN OPPORTUNITIES FOR TWO LYASE ENZYMES." Case Western Reserve University School of Graduate Studies / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=case1485963601042409.

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27

Klingeborn, Mikael. "The prion protein in normal cells and disease : studies on the cellular processing of bovine PrPC and molecular characterization of the Nor98 prion /." Uppsala : Department of Molecular Biosciences, Swedish University of Agricultural Sciences, 2006. http://epsilon.slu.se/2006105.pdf.

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Cong, Xiaojing. "Molecular Simulation Studies on the Prion Protein Variants: Insights into the Intriguing Effects of Mutations." Doctoral thesis, SISSA, 2013. http://hdl.handle.net/20.500.11767/4810.

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Prion diseases, or transmissible spongiform encephalopathies (TSE), are a group of rare fatal neurodegenerative maladies that affect humans and animals. The fundamental breakthrough in TSE research was the discovery of the "prion"⎯proteinaceous infectious particle⎯ and the verification of the “protein-only” hypothesis, which states that prions could self-propagate by converting the cellular prion protein (PrPC) into the scrapie form, PrPSc (or prions), and lead to neurodegeneration without using any nucleic acids. The concept of prions may unify neurodegenerative diseases under a common pathog

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29

Kravchenko, Anna. "Fragment-based modelling of protein-RNA complexes for protein design." Electronic Thesis or Diss., Université de Lorraine, 2023. http://www.theses.fr/2023LORR0370.

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Les complexes protéine-ARN jouent un rôle crucial dans la régulation cellulaire. La prédiction de leur structure 3D a des applications dans la conception de protéines et de médicaments. Le projet ITN RNAct visait à combiner des méthodes expérimentales et informatiques pour concevoir de nouveaux "motifs de reconnaissance de l'ARN" (RRM) - domaines protéiques interagissant avec l'ARN simple brin (ARNsb) - pour la biologie synthétique et la bioanalyse. La modélisation des complexes protéine-ARNsb (amarrage) est ardue car l'ARNsb n'a pas de structure propre dans sa forme libre. L'amarrage traditio

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30

Nanni, Paolo <1979&gt. "Mass spectrometry-based protein profiling strategies for biomarker discovery in liver and inflammatory bowel diseases." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2008. http://amsdottorato.unibo.it/1025/1/Tesi_Nanni_Paolo.pdf.

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The study of protein expression profiles for biomarker discovery in serum and in mammalian cell populations needs the continuous improvement and combination of proteins/peptides separation techniques, mass spectrometry, statistical and bioinformatic approaches. In this thesis work two different mass spectrometry-based protein profiling strategies have been developed and applied to liver and inflammatory bowel diseases (IBDs) for the discovery of new biomarkers. The first of them, based on bulk solid-phase extraction combined with matrix-assisted laser desorption/ionization - Time of Fl

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Nanni, Paolo <1979&gt. "Mass spectrometry-based protein profiling strategies for biomarker discovery in liver and inflammatory bowel diseases." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2008. http://amsdottorato.unibo.it/1025/.

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The study of protein expression profiles for biomarker discovery in serum and in mammalian cell populations needs the continuous improvement and combination of proteins/peptides separation techniques, mass spectrometry, statistical and bioinformatic approaches. In this thesis work two different mass spectrometry-based protein profiling strategies have been developed and applied to liver and inflammatory bowel diseases (IBDs) for the discovery of new biomarkers. The first of them, based on bulk solid-phase extraction combined with matrix-assisted laser desorption/ionization - Time of Fl

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32

Lykidis, Dimitrios Aristotle. "Development of a zinc-based fixative for DNA, RNA and protein molecular studies." Thesis, Imperial College London, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.444137.

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33

Ledmyr, Helena. "Molecular regulation of microsomal triglyceride transfer protein, MTP : functional genetic studies in relation to cardiovascular disease /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-142-3/.

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34

Garousi, Javad. "Development of ADAPT-based tracers for radionuclide molecular imaging of cancer." Doctoral thesis, Uppsala universitet, Institutionen för immunologi, genetik och patologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-327419.

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ABD-Derived Affinity Proteins (ADAPTs) is a novel class of small engineered scaffold proteins based on albumin-binding domain (ABD) of streptococcal protein G. High affinity ADAPT binders against various therapeutic targets can be selected. In this thesis, we report a development of ADAPT-based radionuclide imaging agents providing high sensitivity and specificity of molecular imaging of HER2 expression in disseminated cancers. We investigated the feasibility of the use of ADAPTs as imaging agents and influence of molecular design and radiolabeling chemistry on in vivo targeting and biodistr

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35

Morris, Viktoriya Dickstein Rebecca. "Map-based cloning of the NIP gene in model legume Medicago truncatula." [Denton, Tex.] : University of North Texas, 2007. http://digital.library.unt.edu/permalink/meta-dc-3638.

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Jang, HyeIn. "FUNCTIONAL CHARACTERIZATION OF SCAFFOLD PROTEIN SHOC2." UKnowledge, 2018. https://uknowledge.uky.edu/biochem_etds/39.

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Signaling scaffolds are critical for the correct spatial organization of enzymes within the ERK1/2 signaling pathway and proper transmission of intracellular information. However, mechanisms that control molecular dynamics within scaffolding complexes, as well as biological activities regulated by the specific assemblies, remain unclear. The scaffold protein Shoc2 is critical for transmission of the ERK1/2 pathway signals. Shoc2 accelerates ERK1/2 signaling by integrating Ras and RAF-1 enzymes into a multi-protein complex. Germ-line mutations in shoc2 cause Noonan-like RASopathy, a disorder wi

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37

Szolkiewicz, Michal Jerzy. "Homology-based in silico identification of putative protein-ligand interactions in the malaria parasite." Diss., University of Pretoria, 2014. http://hdl.handle.net/2263/41019.

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Malaria is still one of the most proli c communicable diseases in the world with more than 200 million infections annually, its greatest e ect is felt in the poor nations with-in sub-saharan Africa and south-east Asia. It is especially fatal for women and children where out of the 660 000 fatalities in 2010, 86% were below the age of 5. In the past decade the global fatality rate due to malaria has been signi cantly reduced, primarily due to proliferation of vector control using treated nets and indoor residual spraying of DDT. There have, however, been few innovations in anti-malarial t

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38

Jariwala, Nidhi H. "Characterization of Staphylococcal nuclease and tudor domain containing protein 1 (SND1) as a molecular target in Hepatocellular carcinoma and Non-alcoholic steatohepatitis." VCU Scholars Compass, 2017. https://scholarscompass.vcu.edu/etd/5183.

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CHARACTERIZATION OF STAPHYLOCOCCAL NUCLEASE AND TUDOR DOMAIN CONTAINING PROTEIN 1 (SND1) AS A MOLECULAR TARGET IN HEPATOCELLULAR CARCINOMA AND NON-ALCOHOLIC STEATOHEPATITIS Nidhi Jariwala, PhD A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Integrative Life Sciences Virginia Commonwealth University, 2017 Devanand Sarkar, M.B.B.S., PhD. Associate Professor, Department of Human and Molecular Genetics Virginia Commonwealth University Richmond, Virginia SND1, a subunit of the miRNA regulatory complex RISC, has been implicated as an onco

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39

Stemm, Mina Catherine. "Computational and combinatorial design of protein-based inhibitors of human tyrosyl-DNA phosphodiesterase /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2005. http://wwwlib.umi.com/cr/ucsd/fullcit?p3166399.

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40

Matsumiya, Kentaro. "Destabilization of protein-based emulsions caused by bacteriostatic emulsifiers." Master's thesis, Kyoto University, 2014. http://hdl.handle.net/2433/188746.

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Kyoto University (京都大学)<br>0048<br>新制・論文博士<br>博士(農学)<br>乙第12820号<br>論農博第2793号<br>新制||農||1025(附属図書館)<br>学位論文||H26||N4815(農学部図書室)<br>31307<br>京都大学農学研究科農学専攻<br>(主査)教授松村康生, 教授裏出令子, 教授安達修二<br>学位規則第4条第2項該当

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41

Goldflam, Michael. "Combined use of NMR and computational tools for fragment based drug discovery targeting protein-protein interactions VEGF protein surface recognition as a case study." Doctoral thesis, Universitat de Barcelona, 2013. http://hdl.handle.net/10803/123711.

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The capacity of proteins to interact with each other rests at the core of biology. Given the ubiquitous nature of these interactions they have attracted the attention of scientists for the development of inhibitors or biochemical tools.The use of biologics to target protein-protein interfaces is relatively advanced; suffer although from some intrinsic drawbacks as the danger of immunogenicity, the inability to cross biological barriers efficiently and high production costs. Small molecule inhibitors do not necessarily share these drawbacks. Unfortunately the druggability of protein-protein int

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42

Hunter, Michael. "Molecular investigations of the CMT4D gene N-myc downstream-regulated gene 1 (NDRG1)." University of Western Australia. School of Medicine and Pharmacology, 2006. http://theses.library.uwa.edu.au/adt-WU2007.0034.

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[Truncated abstract] Hereditary Motor and Sensory Neuropathy Lom (HMSNL) is a severe autosomal recessive peripheral neuropathy, the most common form of demyelinating Charcot-Marie-Tooth (CMT) disease in the Roma (Gypsy) population. The mutated gene, N-myc downstream-regulated gene 1 (NDRG1) on chromosome 8q24, is widely expressed and has been implicated in a wide range of processes and pathways. In this study we have aimed to assess the overall contribution of this gene to the pathogenesis of peripheral neuropathies, in cases where the most common causes of CMT disease havebeen excluded, as we

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43

Gulati, Sahil Gulati. "Modulating G Protein-Coupled Receptor Signaling Pathways with Selective Chemical- and Protein-Based Effector Molecules." Case Western Reserve University School of Graduate Studies / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=case1530642105672697.

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Wei, Lixia. "Development of a Novel Protein Based MRI Contrast Agent for Molecular Imaging of Prostate Cancer." Digital Archive @ GSU, 2010. http://digitalarchive.gsu.edu/biology_diss/75.

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Molecular Imaging provides new aspects in cancer diagnosis and treatment. With the ap-plication of imaging and biological techniques, molecular imaging can monitor molecular and cellular changes of different diseases. To interpret the mechanism of disease, more and more at-tention is focused on the development of new probes for molecular imaging. Magnetic resonance imaging (MRI) is a powerful, non-invasive clinical diagnostic tool with high spatial resolution without the limitation of the depth of tissues. Applications of MRI contrast agents can amply the MRI signal during imaging. Many studie

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Choi, Yoon-Aa. "Molecular engineering of new protein labeling methodology based on rational design and in vitro evolution." Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/57981.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2010.<br>Cataloged from PDF version of thesis. Vita.<br>Includes bibliographical references.<br>Site-specific labeling using E coli biotin ligase (BirA) and its 15-amino acid "acceptor peptide" (AP) has been applied to study the function of various cellular proteins. In order to extend the capabilities of biotin ligase-based labeling, we engineered key elements of the labeling platform. First we characterized a novel peptide substrate (called "yeast acceptor peptide" (yAP)) for yeast biotin ligase (yBL) that had been e

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Ratnayake, Wishrawana Sarathi Bandara. "Role of Oncogenic Protein Kinase C-iota in Melanoma Progression; A Study Based on Atypical Protein Kinase-C Inhibitors." Scholar Commons, 2019. https://scholarcommons.usf.edu/etd/7895.

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Irrespective of plentiful efforts to enhance primary prevention and early detection, the number of melanoma cases in the United States has increased steadily over the past 30 years, thus greatly affecting public health and the economy. We have investigated the effects of five novel aPKC inhibitors; 2-acetyl-1,3-cyclopentanedione (ACPD), 3,4-Diaminonaphthalene-2,7-disulfonic acid (DNDA), [4-(5-amino-4-carbamoylimidazol-1-yl)-2,3-dihydroxycyclopentyl] methyl dihydrogen phosphate (ICA-1T) along with its nucleoside analog 5-amino-1-((1R,2S,3S,4R)-2,3-dihydroxy-4-methylcyclopentyl)-1H-imidazole-4-c

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Pan, Tao. "Genetic and physical interaction of Sgt2 protein with prion-chaperone machinery." Thesis, Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/45765.

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The word "Prion" refers to self-perpetuating protein aggregates that cause neurodegenerative diseases in mammals. It is a protein isoform that has undergone a conformational change which converts the normal form of the protein into the infectious form with the same amino acid sequence. Yeast [PSI+] prion is the prion isoform of Sup35 protein, a translation termination factor eRF3. It has been suggested that prion [PSI+] is controlled by the ensemble of chaperones with Hsp104 playing the major role. The previous work performed in the Chernoffs lab showed that the defective GET pathway caused by

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Cuzzolin, Alberto. "Novel in silico approaches to depict the protein-ligand recognition events." Doctoral thesis, Università degli studi di Padova, 2016. http://hdl.handle.net/11577/3424818.

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The discovery and commercialization of a new drug is a long and expensive process. Such process is divided into different phases during which the phisico-chemical and therapeutic properties of the compounds are determined. In particular, the aim of the first phase is to verify whether the compound recognises and interacts efficiently with the target protein. In the last decade, several computational tools have been developed and used to support experimentalists. For this purpose, the scientist have to deal with high complex systems that are difficult to study in whole; thus, the methods and a

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Düzgün, Ali. "Carbon nanotube based potentiometric aptasensors for protein detection." Doctoral thesis, Universitat Rovira i Virgili, 2013. http://hdl.handle.net/10803/111166.

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El diagnóstico rápido de la mayoría de las enfermedades tiene una importancia vital para proporcionar el remedio adecuado y, por lo tanto, el control de problemas de salud. La detección rápida y selectiva de biomoléculas grandes, específicamente proteínas, es uno de los objetivos importantes en este campo. Las técnicas basadas en inmunoensayos son las más comúnmente utilizadas, aunque requieren un marcaje específico. Por lo general, estos métodos también requieren personal altamente capacitado y equipos complejos que se traduce en una metodología relativamente cara y lenta. En la presente t

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Seeley, Kent W. "Mass Spectrometry-based Methods for the Detection and Characterization of Protein-Tyrosine Nitration." Scholar Commons, 2013. http://scholarcommons.usf.edu/etd/4766.

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Protein tyrosine nitration (PTN) is a posttranslational modification resulting from oxidative/nitrosative stress that has been implicated in a wide variety of disease states. Characterization of PTN is challenging due to several factors including its low abundance in a given proteome, preferential site modification, multiple target site proximity within unique peptide sequences, and analytical method and instrument limitations. Current analytical techniques are insufficiently sensitive to identify endogenous nitration sites without incorporation of either nitrotyrosine or target protein enrich

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