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Autor: Grafiati

Data publikacji: 6 września 2023

Data aktualizacji: 31 lipca 2025

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1

Simion, Oana-Maria. "Uncoupling proteins mRNA levels in mice lacking acylation-stimulating protein." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=33018.

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The etiology of obesity involves imbalanced energy intake and utilization. ASP is an adipose tissue hormone that facilitates adipocyte uptake of serum fatty acids and their storage. Mice lacking ASP have less adipose tissue mass, despite increased food intake, than wild-type littermates. We hypothesize that the unstored fuels are oxidized through UCP (thermogenic mitochondrial carriers).<br>In male ASP-deficient mice mRNA levels were measured by semi-quantitative RT-PCR and the following changes were observed: UCP-1 decreased in all tested tissues, UCP-2 increased by 15% and 6 fold in muscle a

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2

Byström, Jonas. "Eosinophil Cationic Protein : Expression Levels and Polymorphisms." Doctoral thesis, Uppsala University, Department of Medical Sciences, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2059.

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<p>The eosinophil cationic protein (ECP) is usually associated with the eosinophil granulocyte. In this thesis the presence and production of this protein has been studied in two other cells. The circulating monocyte was found to contain ECP mRNA and small amounts of ECP, one thousand times less than that found in the eosinophil. The production decreased by differentiation of the myelomonoblastic cell line U937 into a macrophage phenotype. Submucosal lung macrophages did not stain for ECP and alveolar macrophages did not contain ECP mRNA. The circulating neutrophil contains ECP at a level hund

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3

Kachra, Zarin. "Regulation of insulin-like growth factor-I (IGF-I) and IGF-binding protein-1 (IGFBP-1) mRNA levels in cultured rat hepatocytes." Thesis, McGill University, 1993. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=41300.

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The liver is a major site of production of circulating levels of insulin-like growth factor-I (IGF-I) and IGF-binding proteins (IGFBPs). We have used primary cultured rat hepatocytes maintained under serum free conditions to explore the regulatory role of various hormones on hepatic IGF-I and IGFBP-1 mRNA levels.<br>IGF-I mRNA levels were stimulated 2.0 to 2.5 fold by bovine growth hormone (bGH) and 1.8 to 2.0 fold by glucagon but on combining bGH and glucagon, a synergistic effect was observed and IGF-I mRNA level was augmented 10 to 12 fold. Octreotide blocked the hGH induced stimulation of

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4

Schwanhäußer, Björn. "Global analysis of cellular protein dynamics by pulse-labeling and quanti tati ve mass spectrometry." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2011. http://dx.doi.org/10.18452/16305.

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Der erste Teil der Arbeit beschreibt die Etablierung einer modifizierten Form des klassichen SILAC-Verfahrens, das in der quantitativen Massenspektrometrie zur Bestimmung von relativen Änderungen in Proteinmengen benutzt wird. Im sog. „pulsed SILAC (pSILAC)“ Verfahren werden Zellen im Zuge einer differentiellen Behandlung in Kulturmedien transferiert, die unterschiedlich Isotop-markierte Aminosäuren enthalten. Da hier die Quantifizierung auf dem Verhältnis der neusynthetisierten Proteinmengen beruht, können gezielt Unterschiede in der Proteinproduktion bestimmt werden. Mit Hilfe von pSILAC kon

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5

Van, Rooyen Marina. "The modulating effect of myo-inositol and other antidepressants on the mRNA levels and protein expression of selected subcellular enzymes / Marina van Rooyen." Thesis, North-West University, 2005. http://hdl.handle.net/10394/504.

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myo-lnositol (mIns), a natural component of the human diet and essential precursor of several signalling pathways, including that of G protein-coupled receptors, has also been shown to be effective in the treatment of psychiatric disorders such as depression, obsessive compulsive disorder and panic disorder. Most likely since mlns is a simple isomer of glucose, no serious side effects have been reported with its use, even at high oral doses of mlns. Previous studies suggest that the therapeutic action of mlns may include reduced serotonin 5HTzA and muscarinic acetylcholine receptor function. A

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6

Peter, Martina Andrea. "Growth hormone-dependent expression and regulation of insulin-like growth factor (IGF) I and IGF binding protein mRNA levels in rat tissues in vivo /." [S.l.] : [s.n.], 1993. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=10291.

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7

Kogan, Cary. "The expression of neurofilament protein and mRNA levels in the lateral geniculate nucleus and area V1 of the developing and adult vervet monkey (Ceorcopithicus aethiops) /." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0028/MQ50807.pdf.

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8

Beyerle, Jolantha [Verfasser], and Heinz [Akademischer Betreuer] Schmeiser. "Assessment of mRNA, protein levels and activities of xenobiotic metabolizing enzymes in colon and rectal mucosa of colorectal cancer patients / Jolantha Beyerle ; Betreuer: Heinz Schmeiser." Heidelberg : Universitätsbibliothek Heidelberg, 2016. http://d-nb.info/1180736281/34.

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9

Arslan, Sevki. "Effects Of Benzene On Liver, Kidney And Lung Cyp1a, Cyp2b4, Cyp2e1 And Cyp3a6 Mrna, Protein Level, And Drug Metabolizing Enzyme Activities And Toxicity In Diabetic Rabbits." Phd thesis, METU, 2008. http://etd.lib.metu.edu.tr/upload/3/12609446/index.pdf.

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The effects of diabetes on cytochrome P450 dependent drug metabolizing enzymes have not to be clarified yet. The most widely used animals in these studies have been rats, and information regarding the effects of diabetes on cytochrome P450 dependent procarcinogen/carcinogen metabolism in rabbits is limited. In the present study, we investigated, for the first time, the influence of benzene on liver, kidney and lung microsomal cytochrome P450 dependent drug metabolizing enzyme activities, protein and mRNA levels in diabetic and non-diabetic rabbits. Male New Zealand rabbits were made diabetic

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10

Beresford, Guy William. "Control of glucokinase and mRNA levels in hepatocytes." Thesis, University of Newcastle Upon Tyne, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.386292.

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11

Alqara, Yazan Ali. "Protein Interactions in mRNA Methylation Complexes." ScholarWorks@UNO, 2013. http://scholarworks.uno.edu/honors_theses/28.

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Experiments were performed to test sequence and structural specific interactions of proteins with a conserved RNA modification enzyme, which is known as Ime4 in yeast and Mettl3 in mammals. Ime4 methylates N6-adenosine bases on mRNA molecules. The goal of this project is to gain direct insights into how novel proteins interact with Ime4 to form the methyltranferase (MTase) complex and to identify proteins that are essential for Ime4 activity. It has been recognized that there are two proteins that interact within the Ime4 complex, which are known as Mum2 (a cytoplasmic protein essential for me

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12

Jones, David G. L. "Regulation of chick fibronectin mRNA levels by steroid hormones." Thesis, University of Manchester, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.277354.

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13

Vail, Daniel Robert. "Artemisinin Biosynthesis: Developmental and Sugar Regulation of mRNA Levels." Digital WPI, 2008. https://digitalcommons.wpi.edu/etd-theses/415.

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Artemisinin, produced by the plant Artemisia annua, is a sesquiterpene anti-malarial therapeutic. Due to the medicinal relevance of this plant product, there is significant interest in understanding how the biosynthetic pathway is regulated at several key steps. The objective of this study is to examine several factors known to influence artemisinin yields to determine if those effects are occurring at the transcriptional level of the biosynthetic pathway. Artemisinin content has been shown to increase as the plant shifts from vegetative growth to reproductive, flowering growth. To test whet

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14

Wilson, Timothy Craig. "The role of mRNA stability and Fos protein in transient c-fos mRNA accumulation." Thesis, University of Cambridge, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.304567.

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15

Chernov, Konstantin Grigorievich. "Interplay of YB-1 between tubulin and mRNA." Thesis, Evry-Val d'Essonne, 2008. http://www.theses.fr/2008EVRY0040/document.

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YB-1 est un régulateur important de l’expression des gènes dans les cellules eucaryotes. En plus de son rôle dans la transcription, YB-1 joue un rôle clé dans la traduction et la stabilisation des ARN messagers. Nous avons identifié plusieurs nouveaux partenaires de la protéine YB-1 par chromatographie d’affinité à partir de différents extraits tissulaires. Parmi ces partenaires, nous avons démontré que YB-1 interagit avec la tubuline et les microtubules et stimule fortement l'assemblage des microtubules in vitro. Les microtubules assemblés en présence de YB-1 ont une ultrastructure normale, e

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16

Zhang, Jingji. "Accuracy of mRNA Translation in Bacterial Protein Synthesis." Doctoral thesis, Uppsala universitet, Struktur- och molekylärbiologi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-262901.

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Reading of messenger RNA (mRNA) by aminoacyl-tRNAs (aa-tRNAs) on the ribosomes in the bacterial cell occurs with high accuracy. It follows from the physical chemistry of enzymatic reactions that there must be a trade-off between rate and accuracy of initial tRNA selection in protein synthesis: when the current accuracy, the A-value, approaches its maximal possible value, the d-value, the kinetic efficiency of the reaction approaches zero. We have used an in vitro system for mRNA translation with purified E. coli components to estimate the d- and A-values by which aa-tRNAs discriminate between

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17

Glatz, Elisabeth. "Bacillus subtilis GlpP protein, antitermination and mRNA stability." Lund : Lund University, 1998. http://catalog.hathitrust.org/api/volumes/oclc/68945078.html.

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18

Karmouch, Jennifer. "Deciphering ColQ induced mechanisms in the control of AChR mRNA levels." Thesis, Paris 5, 2014. http://www.theses.fr/2014PA05T007/document.

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ColQ est un collagène spécifique qui ancre l’acétylcholinestérase (AChE) dans la fente synaptique de la jonction neuromusculaire (JNM). L'importance du complexe AChE-ColQ dans la physiologie humaine de cette synapse est soulignée par l’identification de mutations dans le gène codant pour ColQ qui conduisent à un syndrome myasthénique congénital (SMC) associé à une déficience en AChE. Le déficit en AChE a, jusqu’à présent, été considéré comme l’unique facteur responsable des symptômes observés chez les patients ainsi que des défauts de la JMN chez le modèle de souris SMC (souris déficiente pour

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19

Spangler, Jacob Brian. "Conserved noncoding sequences regulate steady-state mRNA levels in Arabidopsis thaliana." Thesis, Clemson University, 2013. http://pqdtopen.proquest.com/#viewpdf?dispub=3565242.

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<p> <i>Arabidopsis thaliana</i> has undergone three whole genome duplications within its ancestry, and these events have dramatically affected its gene complement. Of the most recent whole genome duplication events (α event), there remain 11,452 conserved noncoding sequences (CNSs) that have been retained proximal to α duplicate gene pairs. As functional DNA elements are expected to diverge in sequence at a slower rate than nonfunctional DNA elements, the retained CNSs likely encode gene regulatory function. Within this dissertation I provide evidence for the regulatory role of CNS

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20

Smith, Paul Andrew. "Protein-protein interactions of Prp2p : a pre-mRNA splicing factor of Saccharomyces cerevisiae." Thesis, University of Edinburgh, 2000. http://hdl.handle.net/1842/12988.

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A two-fold strategy was adopted to identify factors which functionally interact with Prp2p: 1) the yeast two-hybrid system was utilised to identify Prp2p interacting proteins and, 2) the technique of high copy-number suppression screening was used to search for suppressors of dominant negative <i>PRP2</i> mutations. An exhaustive two-hybrid screen with Prp2p as the bait isolated Spp2p, another step 1 splicing factor that was originally identified as a high copy-number suppressor of a <i>prp2-1</i> mutation. Subsequently the reciprocal interaction was observed in a two-hybrid screen with Spp2p

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21

Wüst, Michaela [Verfasser]. "The protein interactome of human SOD2 mRNA / Michaela Wüst." Tübingen : Universitätsbibliothek Tübingen, 2021. http://d-nb.info/1226756166/34.

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22

Naski, Nadia. "The p53, Mdm2 and Mdmx protein and mRNA interplay." Paris 7, 2010. http://www.theses.fr/2010PA077158.

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Le facteur de transcription p53 est étudié dans le monde entier pour son rôle clé de suppresseur de tumeurs. En effet, le gène codant pour p53 est muté dans plus de 50% des cancers humains. Cependant, des transformations malignes peuvent aussi avoir lieu en présence d'une protéine p53 intacte. Celles-ci seraient causées par l'altération des voies de régulation en amont ou en aval de p53. Cette protéine est, en effet, finement régulée par une multitude de régulateurs positifs et négatifs. Mdm2 et son homologue Mdmx (aussi appelé Mdm4) sont les deux régulateurs négatifs majeurs de p53; ils peuve

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23

SALADINO, Patrizia. "ROLE OF RNA BINDING PROTEIN IN THE NERVE CELL DIFFERENTIATION." Doctoral thesis, Università degli Studi di Palermo, 2014. http://hdl.handle.net/10447/91214.

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Synthesis of H1˚ and H3.3 histone proteins, in the developing rat brain, seems to be regulated mainly at the post-transcriptional level. Since regulation of RNA metabolism depends on a series of RNA-binding proteins (RBPs), we have been searching for RBPs involved in the post-transcriptional regulation of the H1˚ and H3.3 genes. Previously, we reported isolation, from a cDNA expression library, of an insert encoding a novel protein, the C-terminal half of which is identical to that of PEP-19, a brain-specific protein involved in calcium metabolism. The novel protein was called long PEP-19 isof

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24

Ulbricht, Randi J. "Puf1p-mediated mRNA decay and combinatorial control of mRNA stability by the yeast Puf proteins." Diss., St. Louis, Mo. : University of Missouri--St. Louis, 2008. http://etd.umsl.edu/r2761.

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25

Cass, Danielle Marie. "Role of two RNA binding properties in pre-mRNA splicing /." view abstract or download file of text, 2007. http://proquest.umi.com/pqdweb?did=1400950811&sid=2&Fmt=2&clientId=11238&RQT=309&VName=PQD.

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Thesis (Ph. D.)--University of Oregon, 2007.<br>Typescript. Includes vita and abstract. Includes bibliographical references (leaves 67-80). Also available for download via the World Wide Web; free to University of Oregon users.

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26

Mitchell, Michael Robert. "Local Control of Translation and mRNA and Protein Decay is Sufficient for Protein Localization." Thesis, The University of Arizona, 2011. http://hdl.handle.net/10150/144847.

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27

Pryor, Anne M. "Growth-regulated expression and G0-specific turnover of the mRNA that encodes AH49, a mammalian protein highly related to the mRNA export protein UAP56." Connect to this title online, 2003. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1069259604.

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Thesis (Ph. D.)--Ohio State University, 2003.<br>Title from first page of PDF file. Document formatted into pages; contains xii, 187 p.; also includes graphics (some col.) Includes bibliographical references (p. 175-187). Available online via OhioLINK's ETD Center

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28

LU, Zhibo, Mayumi HOJO, Kenji YASUI, Itsuo KODAMA, and Kaichiro KAMIYA. "mRNA Levels of ERG, KVLQT1 and minK in Rabbit Right and Left Ventricles." Research Institute of Environmental Medicine, Nagoya University, 2002. http://hdl.handle.net/2237/2801.

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29

Pettersson, Erik. "Investigation of tissue factor mRNA levels in human platelets using real-time PCR." Thesis, Uppsala universitet, Institutionen för medicinsk biokemi och mikrobiologi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-180831.

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Tissue factor (TF), a 47 kDa glycoprotein, is the initiator of the extrinsic pathway of blood coagulation and consequently of the upmost importance when damage to blood vessel occurs. The source of TF in circulation has been investigated. However, the source of TF is still not clear. One theory is that platelets express and increases the expression of TF after stimulation and the aim of our report was to investigate whether platelets really are a source for TF in circulation. Using specific primers for TF mRNA, platelets in plasma from healthy volunteers and from patients suffering from cardia

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30

Tanay, Véronique Anne-Marie Isabelle. "The action of antidepressant/antipanic drugs on GABA(A) receptor subunit mRNA levels." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0009/NQ34845.pdf.

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31

Jagiełło, Bogumiła 1987. "Investigating protein complexes potentially governing microtubule-dependent MBP mRNA distribution." Doctoral thesis, Universitat Pompeu Fabra, 2018. http://hdl.handle.net/10803/665721.

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La localització de molècules d'ARNm permet regular la síntesi de proteïnes localment i temporalment i això és vital per molts processos cel·lular fonamentals. A Oligodendròcits el transport de l'ARNm de la proteïna bàsica de la mielina (MBP) permet la síntesi local d'aquesta. MBP té una funció essencial en la formació de la beina de mielina que envolta els exons, nodreix les cel·les nervioses i permet la rapida transmissió dels estímuls. Tot i la intensa recerca feta sobre els mecanismes moleculars que condueixen el transport i l'expressió local MBP-ARNm, encara no està clar com l'ARNm és tran

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32

Stojdl, David F. "Protein kinases and the regulation of mRNA splicing and translation." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0016/NQ58294.pdf.

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33

Persdotter, Hedlund Gabriella. "Protein and mRNA Studies of Rat FA1/Pref-1/dlk." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7773.

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34

Kinney, Emma. "Decoupling of HSV1 Vhs protein mRNA decay and translation stimulation." Thesis, University of Missouri - Kansas City, 2013. http://pqdtopen.proquest.com/#viewpdf?dispub=1543940.

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<p> Herpes Simplex Virus Type 1 is a member of the <i>alphaherpesvirinae </i> subfamily within the family <i>Herpesviridae</i>. This virus has both a lytic and latent cycle. Primary infection occurs when the virus enters epithelial cells around the mucosal lining of the nose and mouth. Within the epithelial cells, the virus undergoes an active lytic infection, causing an ulcerated blister, more famously known as a 'cold sore' or 'fever blister'. Once HSV enters the nearby sensory neurons the genome is transported to the neuronal cell body where its latency associated transcripts are activated

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35

Lemay, Guy. "Study of a reovirus protein involved in viral mRNA translation." Thesis, McGill University, 1987. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=75419.

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This thesis concerns the mechanisms responsible for preferential translation of reovirus mRNA in infected cells. The absence of a poly(A) tract at the $3 sp prime$-end is one of the structural differences that distinguishes reovirus mRNA from cellular mRNA. Addition of free poly(A) inhibits in vitro translation at the level of initiation of protein synthesis, probably by competition between free poly(A) and mRNA. Reovirus mRNA is resistant to this inhibition and this property might confer a translational advantage to the viral mRNA. Another difference between reovirus mRNA and cellular mRNA is

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36

Belmont, Brian J. (Brian Joshua). "Engineered mRNA regulation using an inducible protein-RNA aptamer interaction." Thesis, Massachusetts Institute of Technology, 2012. http://hdl.handle.net/1721.1/78136.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biological Engineering, 2012.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (p. 114-131).<br>The importance and pervasiveness of naturally occurring regulation of RNA function in biology is increasingly being recognized. A common regulatory mechanism uses inducible protein-RNA interactions to shape diverse aspects of cellular RNA fate. Recapitulating this using a novel set of protein-RNA interactions is appealing given the potential to subsequently modulate RNA biology in a manner decoupled from

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Bourdeau-Julien, Isabelle. "ALS-associated RNA-binding protein FUS and mRNA translation regulation." Master's thesis, Université Laval, 2020. http://hdl.handle.net/20.500.11794/68742.

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Des mutations dans plusieurs gènes ont été liés à la sclérose latérale amyotrophique (SLA),en particulier dans celui codant pour la protéine Fused in Sarcoma (FUS). Les mutations sont retrouvées dans la partie codant pour le signal de localisation nucléaire, rendant la protéine anormalement abondante dans le cytoplasme. Combiné à d’autres observations, ça suggère qu’un gain de fonction toxique de FUS dans le cytoplasme serait à l’origine de la neurodégénérescence. La SLA est une maladie neurodégénérative qui affecte les neurones moteurs et cause une paralysie progressive. Les mécanismes molécu

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38

Thumdee, Patama. "The prenatal expression of mRNA and protein of the prion protein gene, PRNP, in sheep." [S.l.] : [s.n.], 2007. http://deposit.ddb.de/cgi-bin/dokserv?idn=983755728.

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39

Wang, Jingwei. "Alterations in protein kinase A and protein kinase C activities and protein levels in cardiomyopathy." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0001/MQ32280.pdf.

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40

Le, Cras Timothy David. "Regulation of the levels of mRNA for the LDL receptor and HMG CoA reductase." Thesis, University of Cambridge, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239497.

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41

Henscheid, Kristy L. "Functional conservation and RNA binding of the pre-mRNA splicing factor U2AF65 /." view abstract or download file of text, 2007. http://proquest.umi.com/pqdweb?did=1400950821&sid=5&Fmt=2&clientId=11238&RQT=309&VName=PQD.

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Thesis (Ph. D.)--University of Oregon, 2007.<br>Typescript. Includes vita and abstract. Includes bibliographical references (leaves 129-141). Also available for download via the World Wide Web; free to University of Oregon users.

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42

Guzella, Thiago dos Santos. "Variation in protein expression levels in cell populations." Doctoral thesis, Universidade Nova de Lisboa. Instituto de Tecnologia Química e Biológica, 2013. http://hdl.handle.net/10362/11968.

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Dissertation presented to obtain the Ph.D degree in Systems Biology<br>A widespread observation is that of variation in the expression levels of a molecule when analyzing a snapshot of single cells from a population. One possible explanation for this variation is that there are asynchronous fluctuations throughout time in the expression level of each cell, for example due to noise in gene expression. Another explanation is that there are so-called stable variants, groups of cells that have a permanent bias for a limited range of expression levels compared with the levels observed in a sna

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43

Chen, Jinyun. "REGULATION OF INTRACELLULAR ARYL HYDROCARBON RECEPTOR PROTEIN LEVELS." Scholarly Commons, 2020. https://scholarlycommons.pacific.edu/uop_etds/3675.

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The aryl hydrocarbon receptor (AHR) is a ligand-activated signaling molecule which controls tumor growth and metastasis, T cell differentiation, and liver development. Expression levels of this receptor protein are sensitive to the cellular p23 protein levels in immortalized cancer cell lines. As little as 30% reduction of the p23 cellular content can suppress the AHR function. Here we reported that down-regulation of the p23 protein content in normal, untransformed human bronchial/tracheal epithelial cells to 48% of its content also suppresses the AHR protein levels to 54% of its content. Thi

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Frey, Steffen. "Charakterisierung von Scp160p, einem mRNA- und ribosomenassoziierten Protein in Saccharomyces cerevisiae." [S.l. : s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=966002172.

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Singh, Mamata. "Insights into the Renal Protective Mechanisms of mRNA Binding Protein HuR." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1300995188.

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Turk, Casey M. "Paralemmin splice variants and mRNA and protein expression in breast cancers." Connect to this title, 2008. http://scholarworks.umass.edu/theses/194/.

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Fernandes, Pereira Carina. "The influenza A virus NS1 protein and viral mRNA nuclear export." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/275570.

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Influenza A virus (IAV) replication and transcription occur in the host cell nucleus; a feature which means both the viral genome (vRNA) and mRNA must be exported from the nucleus to the cytoplasm. The mechanism by which vRNA nuclear export is achieved has been well characterised, but how viral mRNAs are exported is poorly understood. The cellular NXF1-dependent mRNA export pathway has been shown to be involved in the export of some viral mRNAs, but how they are recruited to this pathway is unknown. Prior work from our laboratory showed that segment 7 mRNA was inefficiently exported to the cyt

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Gilbert, Agathe. "Impact of protein-protein interactions and phosphorylation on RNA decapping for nonsense mediated mRNA decay (NMD)." Electronic Thesis or Diss., Sorbonne université, 2022. http://www.theses.fr/2022SORUS386.

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Chez Saccharomyces cerevisiae, la voie de dégradation majoritaire des ARN messagers passe par le clivage de la liaison pyrophosphate entre l’ARNm et la structure de la coiffe à l’extrémité 5’. Cette étape, importante pour la dégradation de l’ensemble des ARNm, est particulièrement clé dans la dégradation d’une classe d’ARN instables, cibles de la voie de dégradation nommée nonsense-mediated mRNA decay (NMD). Cette-dernière permet la dégradation de transcrits contenant un codon STOP prémature et donc dépend de la traduction. D’abord considérée comme une voie de dégradation présente à travers le

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Ohlmann, Theophile. "The role of eIF4F in IRES-driven and uncapped mRNA translation." Thesis, University of Sussex, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.336325.

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Sampson, Natalie D. "Identification and functional characterisation of the novel pre-mRNA processing factor SCAF6." Thesis, University of Nottingham, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.272374.

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