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Chang, Ching-Jey George. "Prostate, benign hypertrophy and prostatic carcinoma - a study of cell biology of prostate and chemotherapy for prostatic hypertrophy and prostatic cancer /". The Ohio State University, 1994. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487856906256116.
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Herrera, Maria Lourdes C. "The expression of various growth factors in the normal human prostate, benign prostatic hyperplasia, and prostate carcinoma". Thesis, Hong Kong : University of Hong Kong, 1996. http://sunzi.lib.hku.hk/hkuto/record.jsp?B1754628X.
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Viennois, Emilie. "Impact d'une invalidation de LXRα sur la physiologie prostatique : un dialogue avec la signalisation androgénique". Phd thesis, Université Blaise Pascal - Clermont-Ferrand II, 2011. http://tel.archives-ouvertes.fr/tel-00841380.
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L'hypertrophie bénigne de la prostate (HBP) est une pathologie qui affecte 50% des hommes dès l'âge de 60 ans et qui conduit à des troubles de la miction. L'HBP se caractérise par une hypertrophie exclusive ou composite de plusieurs compartiments tissulaires de la prostate que sont l'épithélium, le stroma et les fibres musculaires qui définissent respectivement les composantes glandulaire, fibreuse et musculaire de cette pathologie. Il a récemment été montré que les souris dépourvues en récepteurs nucléaires LXR (Liver‐X‐receptor) α (souris lxrα‐/‐) développent une hypertrophie de la prostate dont les signes histologiques évoquent une HBP de type fibreuse. Par ailleurs, un des traitements de l'HBP, vise à éteindre la signalisation androgénique en inhibant la conversion de la testostérone en son métabolite actif, la dihydrotestostérone (DHT). Le phénotype d'hypertrophie de la prostate pourrait donc également s'expliquer par une altération de la signalisation androgénique dans les souris lxrα‐/‐. Dans ce contexte, notre projet de recherche a été centré sur l'étude du rôle des LXR dans l'apparition de l'HBP dans sa composante glandulaire et l'analyse des relations moléculaires associant les signalisations dépendantes de LXRα et du récepteur des androgènes (AR) au sein de la prostate. Le phénotype d'HBP observé dans les souris lxrα‐/‐ résulte d'altérations importantes de l'homéostasie de l'épithélium qui miment la composante glandulaire : 1) une activité sécrétoire accrue ; 2) une altération des processus de sécrétion associée à une altération de l'expression des gènes codant des protéines du transport vésiculaire ; 3) une réponse altérée de certains gènes androgéno‐dépendants associée à une hypersensibilité aux androgènes ; 4) des modifications du réseau paracrine reliant le stroma et l'épithélium. Au final, ces travaux définissent LXRα comme un acteur clé de l'homéostasie prostatique et ouvrent des pistes intéressantes pour la compréhension de l'étiologie de l'HBP chez l'homme. Ces résultats montrent qu'il est possible de moduler la réponse androgénique de la prostate en ciblant LXRα. Ainsi, à plus long terme, l'activation pharmacologique de LXRα constitue une piste potentielle dans le traitement de l'HBP.
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Ambrosini, Gina L. "Dietary risk factors for prostate cancer and benign prostatic hyperplasia". University of Western Australia. School of Population Health, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0135.
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[Truncated abstract] This thesis examines the potential role of dietary intake in the development of two common conditions affecting the prostate gland; prostate cancer and benign prostatic hyperplasia (BPH). Diet is of interest as a potential risk factor for prostate cancer because of geographical variations in prostate cancer incidence and increased prostate cancer risks associated with migration from Asian to western countries. Some geographical variation has been suggested for BPH, but this is less certain. However, both prostate cancer and BPH have potential links with diet through their positive associations with sex hormone levels, metabolic syndrome, increased insulin levels and chronic inflammation. In addition, zinc is an essential dietary micronutrient required for semen production in the prostate gland. The original work for this thesis is presented in six manuscripts of which, four have been published in peer-reviewed journals (at the time of thesis completion). BPH investigated in this thesis is defined as surgically-treated BPH. The following hypotheses were investigated. Regarding foods, nutrients and the risk of prostate cancer and BPH: 1. Increasing intakes of fruits, vegetables and zinc are inversely associated with the risk of prostate cancer and BPH 2. Increasing intakes of total fat and calcium are positively associated with the risk of prostate cancer and BPH. 3. Dietary patterns characterised by high meat, processed meat, calcium and fat content are positively associated with the risk of prostate cancer and BPH. 4. Dietary patterns characterised by high fruit and vegetable and low meat content are inversely associated with the risk of prostate cancer and BPH. v Regarding methodological issues related to the study of diet-disease relationships: 5. Dietary patterns (overall diet) elicited from principal components analysis yield stronger diet-disease associations than when studying isolated nutrients. 6. Remotely recalled dietary intake is reliable enough to be used in studies of chronic disease with long latency periods, such as prostate cancer and BPH. Methods: Data from two studies was used to address the hypotheses above. ... Based on the literature reviewed and the original work for this thesis, the most important dietary risk factors for prostate cancer and BPH appear to be those common to western style diets, i.e. diets high in red meat, processed meat, refined grains, dairy products, and low in fruit and vegetables. This type of diet is likely to result in marginal intakes of antioxidants and fibre, excess intakes of fat and possibly, moderate intakes of carcinogens associated with processed meat and meat cooked at high temperatures. These dietary factors have been linked with biomarkers of inflammation, and they support the hypotheses that chronic inflammation is involved in the development of both prostate cancer and BPH. In addition, this work builds on evidence that zinc is an important factor in prostate health. There is scope for more investigation into the reliability of dietary patterns and the use of nutrient patterns as an alternative to focussing on single food components. Further studies on the reliability of remote dietary intake would also be useful. Because of the latency of chronic disease, it can be theorised that remote dietary recall may uncover more robust diet-disease relationships.
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Smith, Carolyn Margaret. "Characterisation of androgen metabolism and 5α-reductase activity in human prostate cells in vitro". Thesis, University College London (University of London), 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.308889.
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Lima, Junior Mario Maciel de 1974. "Analise do perfil genotipico do sistema glutationa S-transferase e citocromo P450 na avaliação de susceptibilidade ao cancer de prostata e de prognostico". [s.n.], 2006. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310275.
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Orientador: Laura Sterian WardDissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas
Made available in DSpace on 2018-08-06T20:05:49Z (GMT). No. of bitstreams: 1 LimaJunior_MarioMacielde_M.pdf: 2114915 bytes, checksum: 56c9d6904dd7e0a16ab5565b0d280b7c (MD5) Previous issue date: 2006
Resumo: O câncer de próstata (CaP) é atualmente a neoplasia maligna mais prevalente no mundo, após os tumores de pele. A incidência dessa enfermidade tem crescido nas últimas décadas devido, principalmente; ao aumento da longevidade da população. Atualmente o CaP tem sido detectado em estágios menos avançados do que no passado. As melhorias dos métodos de diagnóstico contribuem para a detecção precoce dessa neoplasia. Os polimorfismos de genes que codificam enzimas envolvidas na metabolização de drogas e de xenobióticos, como as do sistema Glutationa S-transferase (GST) e Citocromo P450 (CYP), podem estar implicados no risco e prognóstico para neoplasias. Foram avaliados os genótipos de GSTT1, GSTM1, GSTP1, GSTO1 e CYP1A1 em 125 pacientes portadores de câncer de próstata e em 100 indivíduos com hiperplasia prostática benigna. Tempo e atividade ocupacional, tabagismo e outros dados relevantes da história natural da doença foram obtidas por meio de entrevistas. Não foram encontrados quaisquer associações entre os genótipos estudados e o risco de câncer de próstata, tanto avaliando os diferentes genótipos em separado como em combinações, através de análise de regressão logística uni ou multivariada. Não houve associação entre os genótipos estudados e fatores clínicos de risco para câncer de próstata ou quaisquer parâmetros de agressividade do tumor ao diagnóstico ou durante o seguimento. Nossos dados permitem concluir que os genótipos de GST e CYP1A1 não estão associados à susceptibilidade ao câncer de próstata ou à sua evolução na população brasileira estudada
Abstract: Prostate cancer is currently the most common malignancy worldwide, second only to skin tumors. The incidence of prostate cancer has risen dramatically over the last decade, more than can be explained just by the increase in longevity. It is also apparent that prostate cancer is now being detected at less advanced stages than in the past. Increased awareness of the disease and improved detection methods are thought to contribute to this earlier detection. The polymorphic inheritance of human drug-metabolizing enzymes, such as those encoded by the Glutathione-S-Transferase (GST) and the Cytochrome P450 (CYP) systems, may be implicated in both cancer risk and prognostic. We compared GSTT1, GSTM1, GSTO1, GSTP1 e CYP1A1 genotypes of 125 prostate cancer and 100 benign prostatic hyperplasia patients. Lifetime occupational history, cigarette-smoking, and other anamnestic data were obtained through interviews. None of the studied polymorphisms was found associated to prostate cancer risk either considered in separate or in combination, in uni ou multivariate regression logistic analysis. Also, there was no association between genotypes and possible clinical factors of risk, or any parameter of tumor agressiveness at diagnosis or during follow-up. Our data suggest that GST and CYP1A1 genotypes are not associated to the susceptibility to prostate cancer or its outcome in the Brazilian population
Mestrado
Clinica Medica
Mestre em Clinica Medica
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Tsang, K. K. "Screening for benign prostatic hypertrophy". Thesis, University of Edinburgh, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.663068.
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Benign prostatic hypertrophy (BPH) is a very common disease among men aged 50 and its economic burden on health services continues to grow. The advocation for adopting new screening procedure for BPH begins to emerge. However, a new proposal for screening should be under careful scrutiny and ineffective and inappropriate screening must be avoided. A prospective cohort study has been launched to study the frequency, distribution, and natural history of BPH in two well-defined small communities in Central Scotland. Using the data from the cohort study, the hypothesis that a BPH screening programme justifies the stringent criteria set by Wilson and Jungner (1968) to evaluate any proposed programme, could be tested. The hypothesis has to be rejected after taking all the criteria into account. BPH was a major health problem among apparently well middle-age and elderly men in the community. It imposed significant interference in men's daily routine as well as influenced on their psychological general well-being. Although there was a detectable asymptomatic stage, the natural history of BPH from asymptomatic to a clinical stage was not clear. Because of the obscurity of the natural history, the optimum interval between repeated screens of a continuous screening process was unknown. The facilities for diagnosis and treatment could not be met by the present health services. The economic implications of a screening programme could be enormous, though a systemic analysis to evaluate the worthwhileness of the screening programme in economic terms was not conducted.
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COEURDACIER, PIERRE. "Resultats a long terme de la chirurgie pour hypertrophie benigne de prostate". Rennes 1, 1993. http://www.theses.fr/1993REN1M027.
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Ahouandjinou, Theodora Vignon. "Facteurs nutritionnels associés à la présence de lésions précancéreuses de la prostate (PIN) chez des hommes ayant une hypertrophie bénigne de la protestate". Master's thesis, Université Laval, 2008. http://hdl.handle.net/20.500.11794/19946.
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La néoplasie intra-épithéliale prostatique, un des précurseurs possibles du cancer de la prostate, pourrait donner des renseignements sur les causes de ce dernier dans la mesure où ils cohabitent souvent. Dans une étude transversale, réalisée chez 510 hommes traités chirurgicalement pour une hypertrophie bénigne de la prostate, nous avons testé l'hypothèse que les facteurs de risque souvent associés au cancer de la prostate pouvaient être aussi associés à la présence de la néoplasie intra-épithéliale prostatique. La consommation alimentaire au cours de l'année précédant la chirurgie a été documentée par un questionnaire alimentaire détaillé administré par une diététiste. Le tissu prostatique prélevé à la chirurgie a été examiné par un seul pathologiste. Seuls les patients ayant une hypertrophie bénigne et aucune évidence de cancer ont été retenus pour l'étude. La présence de lésions précancéreuses de la prostate (PIN) a été observée chez 81 participants. La majorité des analyses a porté sur les relations entre les facteurs nutritionnels suspectés de jouer un rôle dans le cancer de la prostate et la présence de PIN. Les rapports de cotes ajustés (RC) et leurs intervalles de confiance (IC à 95%) ont été estimés à l'aide de la régression logistique pour les différentes variables des apports alimentaires. Les résultats sont pour la majorité non statistiquement significatifs, seule une importante consommation de carottes avec un RC, comparant le 3ème au premier tercile, de 1,84 (IC à 95% =1,00-3,40), et d'alpha-carotène avec un RC = 1,90 (IC à 95% =1,04-3,45) sont statistiquement significatifs. En regard du nombre d'associations évaluées ces résultats ne suggèrent aucune association entre les facteurs nutritionnels associés au cancer de la prostate et la présence de PIN.
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DUCHEMIN, JEAN-MICHEL. "Place de l'adenomectomie retro-pubienne dans le traitement chirurgical de l'hypertrophie benigne de la prostate". Amiens, 1994. http://www.theses.fr/1994AMIEM090.
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Ghazarossian-Ragni, Evelyne. "Morbidite apres resection transurethrale pour hypertrophie benigne prostatique : a propos de 250 cas". Aix-Marseille 2, 1989. http://www.theses.fr/1989AIX20274.
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Robert, Michèle. "Etude quantitative des constituants épithéliaux et mésenchymateux dans l'hypertrophie bénigne de la prostate : comparaison des résultats obtenus sur pièces d'adénomectomie et biopsies uniques et multiples". Montpellier 1, 1995. http://www.theses.fr/1995MON1T038.
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Ahouandjinou, Vignon Theodora. "Facteurs nutritionnels associés à la présence de lésions précancéreuses de la prostate (PIN) chez des hommes ayant une hypertrophie bénigne de la prostate". Thesis, Université Laval, 2008. http://www.theses.ulaval.ca/2008/25334/25334.pdf.
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Glémain, Pascal. "Etude experimentale de la resistance a l'ecoulement dans un tube collabable : consequences sur l'evaluation de la resistance urethrale et la comprehension de l'hydrodynamique urethrale chez l'homme". Nantes, 1994. http://www.theses.fr/1994NANT18VS.
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Boget, Sophie. "L'implication de certains fibroblast growth factors (Basic FGF, KGF et FGF10) et de leurs récepteurs (FGFR1, FGFR2-IIIb, FGFR2-IIIc et FGFR3) dans l'hypertrophie prostatique bénigne". Lyon 1, 2001. http://www.theses.fr/2001LYO1T197.
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Pan, Shu Ching, i 潘淑卿. "The Assessemet of Clical Outcome and Medical Resource Utilization for Patients with Prostate Hypertrophy UndergoingGreenlight Photoselective Vaporization and Transurethral Resection of Prostate". Thesis, 2013. http://ndltd.ncl.edu.tw/handle/10265337600032752853.
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碩士高雄醫學大學
醫務管理暨醫療資訊學系碩士班
101
Purposes Benign prostate hyperplasia(BPH) is a common disease in elderly. Transurethral resection of prostate(TURP) is the most effective treatment and the gold standard in the past. However, photovaporization of the prostate(PVP) had replaced TURP gradually in recent years. Latest clinical reports had approved the effect of PVP. In Taiwan, there were only several cases reports. Due to the scarcity of analyses on cost- effectiveness and medical cost in Taiwan, we decided to design a study to compare the two methods on medical expenses and effect for bringing some different views to other medical teams. Objective: To compare the differences between the methods for BPH on medical Utilization Analysis Method This study is a retrospective analysis to collect 100 patients with BPH receiving PVP and another 124 patients receiving TURP from January 2008 to March 2011 in a academic medical center and a metropolitan hospital in southern Taiwan. We compared the hospitalization days, surgery time, postoperative bladder irrigation, the days of catheter indwelling, void state, complications, wound pain between these two groups. Discussion of the medical resource utilization, descriptive statistics and inferential statistics were made. Result Medical effect: Patients received green laser vaporization (PVP) had more complication rate than patients received transurethral resection (TURP) (P＝0.002). Included sexual dysfunction(P ＝0.001), post-operative pain (P＝0.016). A significant difference of more operative time was noted in patients received PVP. There was no significant difference in comparing of the rate of urethral stricture, retrograde ejaculation, and urinary infection (P> 0.05). Clinical medical resource utilization The hospital stays in PVP group and TURP group are4.32± 1.29(day) and 4.81 ± 0.8 0(day), (P <0.001), respectively.The duration of bladder irrigation ,catheterization time and were significantly shorter in PVP group.( bladder irrigation 45.60±14.85(h) vs33.98±14.61(h); catheterization time58.88±16.48(h) vs39.56±16.39(h) ,(P <0.001).The operation time was longer in PVP group.（75.65±29.67 min vs 125.89 ±51.66min）.The total health care costs, after deducting the two sets of surgery and special Eisai were not significant differences TURP group 30547 ± 15691 NTD ; PVP group 33028 ± 17790NTD (P> 0.05). Conclusions In this study there is no significant difference in the medical resource utilization of these two groups. But the PVP group have higher resource utilization which was attributed to the following factors: operation time, anesthesia ,hospital stays, and postoperative complication rate. TURP is the gold standard in the operation of BPH. PVP has the advantages of shorter hospital stay, less duration of bladder irrgation and shorter catheterization time. Owning to less intraoperative bleeding .PVP is the alternative treatment in patient with comorbidities and higer anesthesia risks. Regarding the higher postoperative complication rate of PVP group, the further study is warranted.
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Tu, Chang-Chin, i 杜滄進. "A Study of Key Factors of Select Self-paid for Laser Surgery in Male Prostate Hypertrophy". Thesis, 2016. http://ndltd.ncl.edu.tw/handle/s7w8fb.
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碩士義守大學
管理碩博士班
104
Prostate hypertrophy is male longevity disease. When a man is getting older, the prostate cells are also followed gradually hyperplasia. Resulting in larger volume oppression to the urethra, it causes urinary tract problems. On the current surgical treatment are: Transurethral resection of the prostate, transurethral incision of the prostate, transurethral electrovaporization of the prostate and open prostatectomy. These surgeries are paid by the National Health Insurance. The progress of medical technology have been introduced into the laser treatment on prostate hypertrophy in decades, utilizing vaporization or cutting to remove hypertrophy of the prostate. The researches indicate that laser treatment of prostate hypertrophy surgery has the advantages of less bleeding, shorter hospital stays, merger to reduce postoperative complications, for high risk (such as high blood pressure, heart disease) or the patient is not suitable for anesthesia and surgery. The lasers introduced to Taiwan currently include greenlight laser, thulium laser, holmium laser, Nd-YAG laser and so on. Due to the high cost of laser, it is not included in health insurance payments currently. When the patients choose laser treatment, they must afford higher expense for materials fee. This project is based on the model of planned behavior theory. A questionnaire is designed to the study on the men over the age of 40, analysis of men to choose self-paid laser surgery for prostate hypertrophy behavior attitude, subjective norm, perceived behavioral control, behavioral intentions, and behavior. It also analyzes the age, marital status, job occupation , place of residence , education level, household income , family members who have medical background and commerce insurance beyond the national health insurance or not, affecting the relationship with each variable factors . To assume the more positive effect, behavioral intention will be more positive According to the research result, the theory of planned behavior is predictable to affect men choose to pay for laser surgery for prostate hypertrophy factors and explain their behavior. This study provided recommendations for government authorities, medical and health institutions, public people and future researchers as the references for choosing self-paid medical behavior.
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Wei, Li, i 劉力瑋. "Using Over-sampling and Multi-classifier Committee Approach for skewed class distribution – a case study of diagnosis model construction of Benign prostate hypertrophy and Cancer of prostate". Thesis, 2006. http://ndltd.ncl.edu.tw/handle/78752271295978172163.
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碩士國立中正大學
資訊管理所
95
Regarding the non-skewed distribution, to utilize the existing data mining classification to construct the prediction model can reach a certain level of prediction accuracy. However, in the real data mining case, the dataset distribution is always skewed distribution. In clinical case, because the number of healthy people is more than the number of unhealthy people, the collected data would be congenital skewed distribution. If we utilize those dataset with skewed distribution to construct the prediction model, the prediction deviation should be a big problem. There are three existing solutions for skewed distribution – Under-sampling, Over-sampling, and Multi-classifier Committee Approach. This research will utilize Over-sampling and Multi-classifier Committee Approach for skewed distribution and improve them. The research objective is to raise the prediction accuracy of the minor part of the dataset. The case study is the disease of benign prostate hypertrophy and cancer of prostate. And this research will use those data to test the classification efficiency of my algorithm.
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Ahouandjinou, Theodora Vignon. "Facteurs nutritionnels associés à la présence de lésions précancéreuses de la prostate (PIN) chez des hommes ayant une hypertrophie bénigne de la protestate /". 2008. http://www.theses.ulaval.ca/2008/25334/25334.pdf.
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Hong-Yi, Liu, i 劉宏益. "The Sequential Pattern Mining Model on National Health Insurance Research Database- A Case of Prostatic Hypertrophy". Thesis, 2012. http://ndltd.ncl.edu.tw/handle/47564632761001835165.
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碩士僑光科技大學
資訊科技研究所
100
On account of the vigorous development of Internet service, evolutional changes of technology, and progress of times, people do not just record data now. Rather, people apply recorded data to reveal and gain hidden knowledge. Furthermore, more information with better contribution to the society could be prognosticated on the basis of existing facts. This study employs data from a database, the National Health Insurance Research Database (NHIRD), provided by National Health Research Institutes. Since 1995, the launching year of national health insurance, NHIRD collects a massive amount of data, covering more than 95% of the national population. Therefore, the accumulated data are enormous andrepresentative. This study applies AprioriAll algorithm, the most fundamental and most famous one in sequential pattern mining models, to medical records database provided by the Bureau of National Health Insurance. The conditions of maximum and minimum time gaps were also included in the research. Microsoft SQL Sever 2008 was chosen for database construction, as Microsoft Visual Studio 2008 was applied to the practice of models and analysis of target diseases. The research goal is to reveal the sequential pattern of target disease, and to discover supportive cases between target and comorbid diseases as well as superior-subordinate relationships among comorbid diseases. Prostatic hypertrophy was the target used in this study. Analysis and prediction of comorbid diseases and common symptoms after diagnosis of the target disease as well as time frame will help medical professionals and other people in need of relative information understand the relationships between target and comorbid diseases, and can be further applied in practical medication.