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Ambrosini, Gina L. "Dietary risk factors for prostate cancer and benign prostatic hyperplasia". University of Western Australia. School of Population Health, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0135.
Pełny tekst źródłaHaseen, Farhana. "Nutritional factors and lifestyle in prostate cancer patients". Thesis, Queen's University Belfast, 2011. https://kclpure.kcl.ac.uk/portal/en/theses/nutritional-factors-and-lifestyle-in-prostate-cancer-patients(3e845f58-4e1b-4f5c-a5cc-605d084b9868).html.
Pełny tekst źródłaPrice, Alison Jane. "Nutritional and hormonal biomarkers in prostate cancer epidemiology". Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:8d96d746-7c87-4133-b873-e9a8426da953.
Pełny tekst źródłaAhouandjinou, Theodora Vignon. "Facteurs nutritionnels associés à la présence de lésions précancéreuses de la prostate (PIN) chez des hommes ayant une hypertrophie bénigne de la protestate". Master's thesis, Université Laval, 2008. http://hdl.handle.net/20.500.11794/19946.
Pełny tekst źródłaMiller, Elizabeth C. "Studies of nutritional support for prostate cancer prevention and therapy". Connect to resource, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1124140836.
Pełny tekst źródłaTrotter, James Marshall. "Nutrition and cancer : studies on nutritional abnormalities, nutritional support and protein metabolism in malnourished cancer patients /". Title page, contents and abstract only, 1987. http://web4.library.adelaide.edu.au/theses/09MD/09mdt858.pdf.
Pełny tekst źródłaAllen, Naomi E. "Nutritional and genetic determinants of hormone levels in relation to prostate cancer risk". Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365882.
Pełny tekst źródła徐慧恩 i Wai-yan Tsui. "Determination of PTEN mutations in prostate cancer in Chinese". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2001. http://hub.hku.hk/bib/B31969951.
Pełny tekst źródłaKwan, Pak-shing, i 關百誠. "Roles of Daxx in mitosis and prostate carcinogenesis". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43085337.
Pełny tekst źródłaZucchero, Renee A. "Marital adjustment of older adult couples with breast cancer, prostate cancer, and couples without cancer". Virtual Press, 1998. http://liblink.bsu.edu/uhtbin/catkey/1117099.
Pełny tekst źródłaCenter for Gerontology
凌明達 i Ming-tat Patrick Ling. "A study of molecular and cell biology of prostate tumorigenesis in cell culture". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2000. http://hub.hku.hk/bib/B31223102.
Pełny tekst źródłaBull, Caroline Joyce. "Molecular and epidemiological aspects of prostate cancer : the impact of LDL-lowering therapy". Thesis, University of Bristol, 2017. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.742991.
Pełny tekst źródłaHendricks, Roshan. "Genetic analysis of the role of androgen metabolism in the pathogenesis of prostate cancer". Thesis, Stellenbosch : Stellenbosch University, 2004. http://hdl.handle.net/10019.1/49973.
Pełny tekst źródłaENGLISH ABSTRACT: Prostate cancer (CaP) has the highest incidence of any malignancy affecting South African males. The aetiology of prostate carcinoma indicate that ethnicity is one of the most important risk factors. The causes of these ethnic differences are unknown but presumably involve both environmental and genetic factors. Carcinoma of the prostate is androgen dependent, and it has been suggested that variations in androgen metabolism and synthesis may affect an individuals' risk. Therefore, genes involved in these pathways are candidates for determining CaP susceptibility. In this study two candidate genes in the androgen biosynthetic and metabolic pathway were analysed, viz., the androgen receptor gene (AR), involved in androgen transport and transcriptional activation, and the cytochrome p450c17a gene (CYP17), important for testosterone biosynthesis. Comprehensive mutation detection assays were designed (appropriate for analysis of archival paraffin-embedded material) for almost the entire coding region (excluding polymorphic repeat sequences), and including all splice site junctions of the AR gene, as well as the entire coding region of CYP17. The aim of this study was thus to determine the type and frequencies of genetic variants of these androgen metabolism genes within the diverse South African population, and to determine if the observed ethnic variation in the incidence and progression of CaP can be explained by ethnic-based genetic differences. For high sensitivity mutation detection, the most powerful of the pre-screening methods was used, namely denaturing gradient gel electrophoresis (DGGE). 20 CaP and 25 control benign prostatic hyperplasia (BPH) tissue samples were screened in order to identify possible mutations. Blood samples from the same patients were analysed in order to determine whether mutations are germline and therefore present in all cells of the body. Additional blood samples from the Western Province Blood Transfusion Service (WPBTS) (Refer to section 2.1.2, Table) were also analysed in order to determine the frequency of identified polymorphisms within the general population. Certain polymorphisms were further analysed in paraffin-embedded wax material (exclusively from Blacks) to determine the distribution of these polymorphisms in the Black population. Direct sequencing of mutant-containing DNA fragments was performed to determine the exact location and nature of mutation. Using the AR- DGGE assay 4 novel mutations were identified as well as a previously reported codon 211 (E211) polymorphism. With the CYP17- DGGE assay, 3 novel single nucleotide polymorphisms (SNPs) were detected. Three base variants occured, in codons 36 (L36), 46 (H46) and 65 (S65), as well as intronic substitutions in intron 4 (IVS+58G4C) and intron 6 (IVS-25C7A). Frequencies of SNPs were measured in the CaP and BPH samples. In conclusion, the identified polymorphisms could be used as markers in determining CaP susceptibility and may thus facilitate the identification of individuals with a high- or low-risk of developing carcinoma of the prostate.
AFRIKAANSE OPSOMMING: Prostaatkanker vertoon die hoogste voorkoms van enige kwaardaardigheid wat Suid-Afrikaanse mans aantas. Die etiologie van prostaatkarsinoom dui aan dat etnisiteit een van die mees belangrike risikofaktore is. Oorsake van hierdie etniese verskille is onbekend, maar vermoedelik is omgewing en genetiese faktore albei betrokke. Karsinoom van die prostaat is androgeenafhanklik en daar is voorgestel dat variasies in androgeenmetabolisme en androgeensintese 'n persoon se risiko mag affekteer. Gevolglik, is gene betrokke in hierdie paaie kandidate vir die bepaling van prostaatkanker vatbaarheid. In hierdie studie het ons twee kandidaat gene in die androgeen biosintetiese en metaboliese pad geanaliseer, naamlik, die androgeen reseptor geen (AR), betrokke in androgeen vervoer en aktivering van transkripsie, en die sitokroom p450c17a geen (CYP17), belangrik vir testosteroon biosintese. Ons het omvattende mutasie-bespeurings-essai-sisteme ontwikkel (ook uitvoerbaar op argivale paraffien-bewaarde materiaal), wat amper vir die hele koderende streek van die AR geen gebruik kan word (uitsluitend herhalende polimorfiese reekse) en wat alle splytpunt-aansluitings van die AR geen insluit, asook vir die hele koderende streek van CYP17. Die doel van hierdie studie was dus om die tipe en frekwensies van genetiese variante van androgeen metabolisme gene in ons diverse Suid-Afrikaanse bevolking te bepaal, en om vas te stel of die waarneembare etniese wisseling in die insidensie en vordering van prostaatkanker verstaan kan word deur etnies gebaseerde genetiese verskille. Die mees sensitiewe tegniek wat tans beskikbaar is vir vooraf-sifting vir onbekende mutasies is gekies, naamlik denaturerende gradiënt gel elektroforese (DGGE). Om moontlike mutasies op te spoor, het ons 20 prostaatkanker en 25 benijne prostaathiperplasie (BPH) monsters geanaliseer. Analise was gedoen op bloedmonsters van dieselfde pasiënte om vas te stel of kiemlyn mutasies (in alle liggaamselle) teenwoordig is. Bykomstige bloedmonsters (van die Westelike Provinsie Bloedoortappingsdiens) is ook geanaliseer om die frekwensie van bespeurde polimorfismes in die algemene bevolking te bepaal. Argivale paraffien-bewaarde materiaal (eksklusief van Swartes) is ook geanaliseer om die verspreiding van sekere polimorfismes in die Swart bevolking te bepaal. Direkte DNA volgorde bepaling van mutante DNA fragmente is uitgevoer om die ligging en tipe van mutasies te bepaal. Met die toepassing van ons AR-DGGE mutasiesisteem het ons 4 nuwe mutasies ontdek asook 'n kodon 211 (E211) polimorfisme wat voorheen gevind is. Vyf enkel nukleotied polimorfismes is met die CYP17-DGGE mutasiesisteem opgespoor. Die polimorfismes sluit in: drie basis veranderinge wat voorkom in kodons 36 (L36), 46 (H46) en 65 (S65), asook introniese substitutisies in intron 4 (IVS+58G4C) en intron 6 (IVS-25C7 A). Frekwensies van die polimorfismes was bereken in die prostaatkanker en BPH monsters. Die resultate aangebied in hierdie tesis dui aan dat die gevonde polimorfismes as merkers gebruik kan word om prostaatkanker vatbaarheid te bepaal en daardeur individue te identifiseer met 'n hoë of lae risiko vir prostaatkarsinoom ontwikkeling.
Khoo, Kong Kheong. "The influence of metabolic phenotypes upon the development of colorectal neoplasia /". Title page, table of contents and conclusions only, 1995. http://web4.library.adelaide.edu.au/theses/09MD/09mdk45.pdf.
Pełny tekst źródłaTaveroff, Arlene. "Metabolic derangements following bone marrow transplantation : an integrated analysis". Thesis, McGill University, 1989. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=74259.
Pełny tekst źródłaPettersson, Anna. "Diet and Gastrointestinal Symptoms in Patients with Prostate Cancer Treated with Radiotherapy". Doctoral thesis, Uppsala universitet, Enheten för onkologi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-215410.
Pełny tekst źródłaGharieb, Katia. "Exposition précoce aux toxiques et déséquilibres nutritionnels : l’inflammation et les lésions précancéreuses de la prostate". Thesis, Université Côte d'Azur (ComUE), 2017. http://www.theses.fr/2017AZUR4125/document.
Pełny tekst źródłaNon-communicable diseases (NCDs) including cardiovascular diseases, cancers, respiratory diseases and diabetes kill 38 million people worldwide every year, 16 million of them before the age of 70. Until the 1990s, the origin of these pathologies was associated with the lifestyle of the individual: consumption of tobacco, alcohol, physical inactivity and an unbalanced diet. Since the development of the concept of DOHaD, identifying the developmental origins of health and disease, number of evidence showed that NCDs have, in part, an early origin during the peri-conception period (in utero, first years of life). Exposure during this period to food imbalances, toxic chemicals, synthetic chemicals disrupting endogenous hormones (endocrine disruptors, EDCs) may impact the developing body through epigenetic changes imprinted by the environmental factors to which individuals are exposed. However, the phenotypes and mechanisms involved are still far from being decrypted. During this thesis, we focused on developmental effects on the prostate. In fact, prostate cancer (PCa) is the second leading cause of cancer and the fifth leading cause of death by cancer in the world. Data from the literature shows that dietary imbalances (High Fat Diet, HFD) and estrogen-like EDCs are risk factors for this cancer. We developed an experimental model of rats (young adults, 90 days postnatal) exposed during pregnancy until weaning to HFD (60% fat), or estrogen (estradiol benzoate, EB) during the neonatal period, or a combination of both, to explore the effects on the prostate (ventral lobe). Peri-natal exposure to EB or EB + HFD reduces the weight of the adult prostate. This abnormality is associated with low (HFD), moderate (EB) or massive (EB + HFD) prostate inflammation. The infiltrate is composed mainly of macrophages and T lymphocytes. This inflammation is associated with an increase in the prostate of pro-inflammatory cytokine TNFa, CCL2 / MCP1 (EB) but also IL-6 (EB + HFD) as well as a deregulation of the NLRP3 inflammasome. NLRP3 is chronically activated since its substrates IL1b and IL-18 were over expressed. In conclusion, we show that peri-conception exposure to an estrogen or HFD + EB combination programs prostatic lesions in adult animals. In men, it is suggested that chronic inflammatory lesions (proliferative inflammatory atrophy) would, as for other organs, be a first step towards the onset of carcinogenesis. Thus, our experimental model is relevant for the study of the early stages of prostatic tumorigenesis
Park, Jin Young. "Diet, lifestyle factors and colorectal cancer risk : with focus on methodological issues". Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609120.
Pełny tekst źródłaKwok, Wai-kei, i 郭慧琪. "Oncogenic function of TWIST in the development and progression of prostate cancer". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B3893825X.
Pełny tekst źródłaRobinson, David. "Prediction of survival in prostate cancer : aspects on localised, locally advanced and metastatic disease". Doctoral thesis, Linköping : Department of Clinical and Experimental Medicine, Linköping University, 2008. http://www.bibl.liu.se/liupubl/disp/disp2008/med1073s.pdf.
Pełny tekst źródłaKlopper, Tanya. "Safety and efficacy of n-3 enriched nutritional supplements in the management of cancer cachexia". Thesis, Stellenbosch : University of Stellenbosch, 2006. http://hdl.handle.net/10019.1/1554.
Pełny tekst źródłaBackground At least 40 - 80% of all cancer patients develop some degree of clinical malnutrition and cachexia. The complex and multi-factorial nature of cancer cachexia and the inability of conventional nutrition intervention to reverse or attenuate the effects of this syndrome have driven investigators to consider new therapies and approaches to manage the syndrome of cancer cachexia including eicosapentaenoic acid (EPA), an n-3 fatty acid of fish oil origin. Objectives The aim of this study was to review Phase I, Phase II and Phase III (RCT) trials investigating the safety and efficacy of n-3 supplementation in the treatment of cancer cachexia in adult patients with unresectable solid tumours, with special reference to weight loss, body composition, appetite, dietary intake, energy expenditure, functional status, acute phase response and quality of life. Adverse effects associated with EPA supplementation were also reviewed. Methodology and data collection The major databases were systematically searched for studies that met the inclusion criteria using a structured keyword search strategy or various combinations of these keywords. Relevancy of studies was assessed by two independent reviewers according to pre-determined inclusion and exclusion criteria. Quality was assessed by two independent reviewers using the Jadad scale. Data extraction was performed by the principal reviewer and one of the independent reviewers, and investigators of the included studies were contacted where further information was required. Meta-analysis was not appropriate due to heterogeneity of the data. However, where possible, the paired t-test was used for analysis of the data. Descriptive or non-quantitative analysis of the tabulated data provided a summary of the characteristics of the included studies enabling comparisons to be made between interventions and outcomes within the specified population. Results The search resulted in a total of 1408 citations, of which only 16 studies met the inclusion and exclusion criteria. Of these, only 4 studies were of a good quality. Although the reported data was incomplete and variable, the combined analyses suggested that the effect of EPA supplementation on weight, fat mass, dietary intake, energy expenditure, and acute phase response was not significant. Interestingly there appeared to be a significant increase increased or decreased? in lean body mass (p<0.05). There was little or no data to draw any conclusions regarding the effect of supplementation on appetite and quality of life. Conclusion Despite several limitations in this review, the data collected and analysed are suggestive of the beneficial effects of EPA supplementation, but there remains a significant lack of substantial evidence and conclusive statistical analysis to confirm that EPA supplementation is a safe and effective method of intervention in the management of patients with cancer cachexia.
歐陽雪松 i Xuesong Ouyang. "Differential gene expression during sex hormone-induced prostate carcinogenesis in the rat with emphasis on ID-1 gene and its role inhuman prostate cancer". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2001. http://hub.hku.hk/bib/B29979055.
Pełny tekst źródłaThiel, Colleen. "Resilience in families of husbands with prostate cancer". Thesis, Link to the online version, 2005. http://hdl.handle.net/10019/1237.
Pełny tekst źródłaLoh, Yet Hua. "Diet, MGMT and SMAD7 gene variants and breast, prostate and colorectal cancer risk : results from the EPIC-Norfolk study". Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608981.
Pełny tekst źródłaGallagher, Sandra. "An investigation into the effects of protease activated receptors on biological aspects of prostate cancer progression". Thesis, Queen's University Belfast, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.431613.
Pełny tekst źródłaTam, Chun-wai, i 談振偉. "Secreted PDZ domain-containing protein 2 (sPDZD2): a potential autocrine tumor suppressor". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39557376.
Pełny tekst źródłaSlegtenhorst, Sonja. "Antioxidant intake in paediatric oncology patients". Thesis, Stellenbosch : Stellenbosch University, 2011. http://hdl.handle.net/10019.1/18050.
Pełny tekst źródłaENGLISH ABSTRACT: Background: The role of antioxidants and adequate nutrition in the prevention and course of cancer treatment is globally recognised in nullifying the effects of free radicals and increasing the nutritional status of children during treatment. Objective: To investigate whether children with cancer meet their Dietary Reference Values and Safe Intakes for antioxidants, energy and protein. Design: Single centre prospective study. Setting: Children were recruited from the East of England Primary Treatment Centre using convenience sampling over 8 months. Forty-two children and adolescents diagnosed with a Solid tumour, Lymphoma or Leukaemia were eligible for data analysis (n=20 male; n=22 female). Method: Data was collected with an Estimated Food Record (EFR) in the 1st (EFR1) and 3rd month (EFR2) post-diagnosis. In the week following EFR completion, parents and/or children were contacted to complete four non-consecutive days of 24-hr food recalls. Data was categorised into diet alone, diet + food supplement (FS), tube feeding (tube) or diet + multi-vitamin-mineral supplementation (VMS). Malnutrition was determined by weight-for-age z-scores. Nutrient intake was compared to the Recommended Nutrient Intake (RNI), the Estimated Average Requirements (EAR) and the Lower Recommended Nutrient Intake (LRNI). Result: The sample consisted of 33% (n=14) diagnosed with Leukaemia, 24% (n=10) with Lymphoma and 43% (n=18) with Solid tumours. Sixty seven percent (n=28) underwent chemotherapy and 33% (n=14) a combination of therapies. Significant correlations were seen between the assessment tools in the diet alone category for both months for; vitamins A, C, E, selenium and protein and for EFR1 for zinc and energy. In both months greater numbers of children achieved ≥100% of requirements for diet + VMS (EFR 1; p<0.05; EFR2 p<0.05) than for other feeding modes. Vitamin C achieved the highest intakes compared to the RNI at 773% (EFR1) and 829% (EFR2). Intakes above 200% of the RNI were seen for vitamins A, C, E, selenium and zinc. No significant differences were seen between modes of feeding in either month for selenium or zinc. Vitamin A (EFR1≤ 100% diet alone p<0.05) and zinc (EFR1≤ 100% diet alone p=0.02) met the least of the LRNI in the 1st month compared to other antioxidants. No statistical significant difference was observed between the number of children attaining their EAR’s between the 3 modes of feeding in the 1st month and 3rd month. In the 1st month 27% (n=8) of participants consumed vitamin and/or mineral supplements, 18% in the 3rd month (n=4). In the 1st month 5% (n=2) of children were moderately malnourished and 10% (n=4) in 3rd month. Conversely in the 1st month 3% (n=1) were overweight and 3% (n=1) obese; the leukaemia group predominant. Conclusion: The research tools showed good correlation. Children using vitamin and/or mineral supplements mostly achieved their RNI’s compared to other feeding modes. Across feeding modes some children achieved antioxidant intakes above 200% RNI. LRNI’s on diet alone were not achieved for vitamin A and zinc. The study showed Leukaemics as having a higher prevalence of obesity. More research is required to determine the clinical implications of these findings.
AFRIKAANSE OPSOMMING: Agtergrond: Die rol van anti-oksidante en voldoende voeding in die voorkoming en verloop van kanker behandeling word wêreldwyd erken vir vernietiging van die effek van vry radikale en die verbetering van voedingstatus van kinders tydens behandeling. Doelwit: Om ondersoek in te stel of kinders met kanker hul Dieet Verwysingswaardes en Veilige Innames vir anti-oksidante, energie en proteïen bereik. Ontwerp: Enkel sentrum prospektiewe studie. Omgewing: Kinders was gewerf deur middel van gerieflikheidsteekproefneming oor 8 maande vanaf die “East of England Primary Treatment Centre”. Twee-en-veertig kinders en adolessente gediagnoseer met 'n Soliede tumor, Limfoom of Leukemie het in aanmerking gekom vir dataanalise (n=20 manlik, n=22 vroulik). Metode: Data was ingesamel met ‘n Geskatte Voedsel Rekord (GVR) in die eerste (GVR1) en derde maand (GVR2) na diagnose. In die week na voltooiing van die GVR is ouers en/of kinders gekontak om vier onopeenvolgende dae van 24-uur herroepe te voltooi. Data was verdeel in dieet alleen, dieet + voedsel supplement (VS), buisvoeding (buis) of dieet + multi-vitamien-mineraal supplementasie (VMS). Wanvoeding was bepaal deur middel van gewig-vir-ouderdom z-tellings. Nutriënt inname was vergelyk met die Aanbevole Nutriënt Inname (ANI), die Geskatte Gemiddelde Behoeftes (GGB) en die Laer Aanbevole Nutriënt Inname (LANI). Resultate: Die steekproef het bestaan uit 33% (n=14) gediagnoseer met Leukemie, 24% (n=10) Limfoom en 43% (n=18) Soliede tumore. Sewe-en-sestig persent (n=28) het chemoterapie ontvang en 33% (n=14) ‘n kombinasie van terapieë. Betekenisvolle korrelasies was waargeneem tussen die assesseringsinstrumente in die dieet alleen kategorie vir beide maande vir vitamiene A, C, E, selenium en proteïen en vir GVR1 ook vir sink en energie. In beide maande het ‘n groter aantal kinders ≥100% van hul behoeftes bereik vr dieet+VMS (GVR1; p<0.05; GVR2 p<0.05) as vir ander modi van voeding. Vitamien C het die hoogste innames bereik vergeleke met die ANI teen 773% (GVR1) en 829% (GVR2). Innames bo 200% van die ANI was waargeneem vir vitamiene A, C, E, selenium en sink. Geen betekenisvolle verskille was waargeneem tussen modi van voeding in enige maand vir selenium en sink nie. Vitamien A (GVR1≤100% dieet alleen p<0.05) en sink (GVR1≤100% dieet alleen p=0.02) het die minste van die LANI bereik in die eerste maand vergeleke met ander anti-oksidante. Geen statisties beduidende verskil was waargeneem tussen die aantal kinders wat hul GGB’s bereik het tussen die 3 voedingswyses in die eerste en derde maande nie. In die eerste maand het 27% (n=8) van deelnemers vitamien en/of mineraal supplemente ingeneem, en 18% (n=4) in die derde maand. In die eerste maand was 5% (n=2) van kinders matig wangevoed en 10% (n=4) in die derde maand. In die eerste maand was 3% (n=1) van kinders oorgewig en 3% (n=1) vetsugtig, die leukemie groep spesifiek. Gevolgtrekking: Die navorsingsinstrumente het goeie korrelasie getoon. Kinders wat vitamien en/of mineraal supplemente gebruik het het meestal hul ANI’s bereik vergeleke met ander modi van voeding. Oor voeding modi het sommige kinders anti-oksidant innames bo 200% ANI bereik. LANI’s op dieet alleen was nie bereik vir Vitamien A en sink nie. Hierdie studie het aangetoon dat dié met Leukemia ‘n hoër prevalensie van oorgewig/vetsug getoon het. Meer navorsing is nodig om die kliniese implikasies van die bevindinge te bepaal.
Pang, Bo, i 龐博. "Antiproliferative actions of melatonin and secreted PDZ domain-containing protein 2 (sPDZD2) on tumor cells". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43224064.
Pełny tekst źródłaDiemert, Lindsey. "A Sweet Cherry Feeding Trial in Healthy, Overweight Males: Anthocyanin Bioavailability and Inflammatory Biomarker Response". Thesis, The University of Arizona, 2011. http://hdl.handle.net/10150/203500.
Pełny tekst źródłaVan, Zyl Elizma. "Glutamine supplementation in oncology : a systematic review". Thesis, Stellenbosch : University of Stellenbosch, 2010. http://hdl.handle.net/10019.1/5198.
Pełny tekst źródłaENGLISH ABSTRACT: See full text for abstract
AFRIKAANSE OPSOMMING: Sien volteks vir opsomming
Wong, Yee-man Kimmi, i 黃綺雯. "Expression and functional analysis of a mutant sPDZD2 protein". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B45010468.
Pełny tekst źródłaLecuyer, Lucie. "Signatures métabolomiques associées au risque à long terme de cancers du sein et de la prostate et à l’alimentation dans la cohorte SU.VI.MAX : Nouveaux horizons ouverts par la métabolomique appliquée à l’épidémiologie nutritionnelle". Thesis, Paris 13, 2019. http://www.theses.fr/2019PA131023.
Pełny tekst źródłaBreast and prostate cancers are among the cancers with the highest incidence worldwide and notably in Western countries. The main current challenges lie in the improvement of understanding of nutrition/health relationships and in the identification of individuals at higher risk long before the development of overt cancer to set up prevention actions. A variety of factors exert an impact on the onset and progression of cancer. Among these, nutrition appears as a key factor, in that it can be modified and acted upon through interventions. It is therefore crucial to assess its contribution. For this purpose,detailed and accurate assessment of nutritional intake is essential. Metabolomics, allowing the identification of endogenous, exogenous and microbial biomarkers, opens new perspectives in nutritional epidemiology. So far, few have studies investigated the impact of overall diet on metabolism and risk of breast and prostate cancer through metabolomic profiling. As part of this thesis, we conducted nested case-controls and cross-sectional studies within the SU.VI.MAX cohort to highlight plasma signatures of breast and prostate cancer risks and of overall diet. Plasma samples were collected at baseline and were analysed using two complementary methods : mass spectrometry coupled with liquid chromatography and proton nuclear magnetic resonance. Participants dietary habits were estimated using repeated 24h dietary records and socio-demographic and lifestyle data were collected from self-administered questionnaires.These investigations highlighted endogenous and microbial metabolites associated with overall diet as well as candidate biomarkers of specific dietary exposures. We also identified endogenous, exogenous and microbial metabolites associated with breast and prostate cancers risk suggesting a metabolic disruption up to 13 years before cancer diagnostic. Furthermore, diet appears to be implicated in the variation in plasma levels of some metabolites discriminating individuals at higher risk of developing breast or prostate cancers. These results need to be replicated in future independent observational and interventional studies. In the future, the identification of robust metabolic signatures of breast and prostate cancers risk, of the impact of diet on metabolism and carcinogenesis, and food intake would contribute to better understand health and environment relationships, to better estimate nutritional exposure or even to contribute to the set-up of new public health recommendations in order to reduce the incidence of these pathologies
Taskinen, Mervi. "Skeletal muscle protein reserves in children with cancer : nutritional and metabolic aspects from diagnosis to long-term follow-up". Helsinki : University of Helsinki, 2000. http://ethesis.helsinki.fi/julkaisut/laa/kliin/vk/taskinen/.
Pełny tekst źródłaChen, Chujian 1966. "Antitumor properties of kefir : possible bioactive component(s) and mechanism(s)". Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=85139.
Pełny tekst źródłaAbel, Stefan. "Fatty acids as cancer preventive tools in the dietary modulation of altered lipid profiles associated with hepatocarcinogenesis". Thesis, University of the Western Cape, 2005. http://etd.uwc.ac.za/index.php?module=etd&.
Pełny tekst źródłaDi, Kaijun, i 狄凱軍. "The role of Id-1 on the proliferation, motility and mitotic regulationof prostate epithelial cells". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B38944704.
Pełny tekst źródłaMehrfar, Parisa. "Biological markers of weight loss and muscle protein metabolism in early non-small cell lung cancer". Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=116069.
Pełny tekst źródłaSibani, Sahar. "Genetic and nutritional folate deficiency : implications for homocystinuria and intestinal neoplasia". Thesis, McGill University, 2000. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=31539.
Pełny tekst źródłaThe more common and mild deficiency observed in the general healthy population is probably due in part to insufficient dietary intake of folate. Folate deficiency has been associated with increased risk for colon cancer. In a pilot study presented here, the impact of altered folate intake on tumor multiplicity in the Min mouse, a model for multiple intestinal neoplasia, was assessed. Folate deficient diets did not produce a consistent change in tumor numbers. However, a linear correlation between S-adenosylmethionine and S-adenosylhomocysteine content of preneoplastic tissue and tumor multiplicity was identified.
This thesis contributes to our understanding of the impact of genetic- and/or dietary-induced folate deficiency on cellular and organismal functions.
Rogers, Wendy J. "Effects of dietary stearic and linoleic acid on mammary carcinogenesis and longevity of aging strain A/ST mice". Virtual Press, 1998. http://liblink.bsu.edu/uhtbin/catkey/1115733.
Pełny tekst źródłaDepartment of Biology
Carman, Judith Anne. "The metabolic relationship between nutrition and cancer /". Title page, contents and abstract only, 1988. http://web4.library.adelaide.edu.au/theses/09PH/09phc287.pdf.
Pełny tekst źródłaBulcao, Candice. "Polyunsaturated fatty acid metabolism and effects on colon cancer cell biology in vitro". Thesis, Rhodes University, 2013. http://hdl.handle.net/10962/d1016128.
Pełny tekst źródłaZhang, Xiaomeng, i 張效萌. "Significance and molecular basis of Id-1 in regulation of cancer cell survival and invasion". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39325477.
Pełny tekst źródłaGridley, Shelly M. "The effect of dietary fatty acids on cholesterol/phospholipid ratios and fatty acids in plasma membranes of spontaneous mammary tumors from strain A/ST mice". Virtual Press, 1989. http://liblink.bsu.edu/uhtbin/catkey/722452.
Pełny tekst źródłaDepartment of Biology
Mina, Kym Deanne. "Measurement of fish consumption in population-based studies of cancer". University of Western Australia. School of Population Health, 2007. http://theses.library.uwa.edu.au/adt-WU2007.0093.
Pełny tekst źródłaRohan, Thomas Edward. "Diet, hormones and breast cancer : a case-control study in women /". Title page, table of contents, summary and appendices only, 1986. http://web4.library.adelaide.edu.au/theses/09PH/09phr7373.pdf.
Pełny tekst źródłaTabatabaei, Seyed Mehdi. "The relationship between dietary factors, meat consumption, heterocyclic amines, Benzo[a]pyrene, meat-derived mutagenic activity and colorectal cancer in Western Australia". University of Western Australia. School of Population Health, 2009. http://theses.library.uwa.edu.au/adt-WU2010.0059.
Pełny tekst źródłaAx, Erika. "Dietary Patterns : Identification and Health Implications in the Swedish Population". Doctoral thesis, Uppsala universitet, Klinisk nutrition och metabolism, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-250280.
Pełny tekst źródłaWinger, Joseph G. "Diet and exercise intervention adherence and health-related outcomes among older long-term breast, prostate, and colorectal cancer survivors". Thesis, 2013. http://hdl.handle.net/1805/5068.
Pełny tekst źródłaGiven the numerous benefits of a healthy diet and exercise for cancer survivors, there has been an increase in the number of lifestyle intervention trials for this population in recent years. However, the extent to which adherence to a diet and exercise intervention predicts health-related outcomes among cancer survivors is currently unknown. To address this question, data from the Reach out to ENhancE Wellness in Older Cancer Survivors (RENEW) diet and exercise intervention trial were analyzed. RENEW was a yearlong telephone and mailed print intervention for 641 older (>65 years of age), overweight (body mass index: 25.0-39.9), long-term (>5 years post-diagnosis) survivors of colorectal, breast, and prostate cancer. Participants were randomized to the diet and exercise intervention or a delayed-intervention control condition. The RENEW telephone counseling sessions were based on determinants of behavior derived from Social Cognitive Theory (SCT) (e.g., building social support, enhancing self-efficacy). These factors have been hypothesized to improve health behaviors, which in turn should improve health outcomes. Thus, drawing on SCT and prior diet and exercise research with cancer survivors, I hypothesized that telephone counseling session attendance would be indirectly related to health-related outcomes (i.e., physical function, basic and advanced lower extremity function, mental health, and body mass index) through intervention-period strength and endurance exercise and dietary behavior (i.e., fruit and vegetable intake, saturated fat intake). The proposed model showed good fit to the data; however, not all of the hypothesized relationships were supported. Specifically, increased telephone counseling session attendance was related to engagement in all of the health behaviors over the intervention period. In turn, (a) increased endurance exercise was related to improvement in all of the health-related outcomes with the exception of mental health; (b) increased strength exercise was solely related to improved mental health; (c) increased fruit and vegetable intake was only related to improved basic lower extremity function; and (d) saturated fat intake was not related to any of the health-related outcomes. Taken together, these findings suggest that SCT determinants of behavior and the importance of session attendance should continue to be emphasized in diet and exercise interventions. Continued exploration of the relationship between adherence to a diet and exercise intervention and health-related outcomes will inform the development of more cost-effective and efficacious interventions for cancer and other medical populations.
Reger, Michael Kent. "Dietary intake and urinary excretion of phytoestrogens in relation to cancer and cardiovascular disease". Thesis, 2014. http://hdl.handle.net/1805/6053.
Pełny tekst źródłaPhytoestrogens that abound in soy products, legumes, and chickpeas can induce biologic responses in animals and humans due to structural similarity to 17β-estradiol. Although experimental studies suggest that phytoestrogen intake may alter the risk of cancer and cardiovascular disease, few epidemiologic studies have investigated this research question. This dissertation investigated the associations of intake of total and individual phytoestrogens and their urinary biomarkers with these chronic conditions using data previously collected from two US national cohort studies (NHANES and PLCO). Utilizing NHANES data with urinary phytoestrogen concentrations and follow-up mortality, Cox proportional hazards regression (HR; 95% CI) were performed to evaluate the association between total cancer, cardiovascular disease, and all-cause mortality and urinary phytoestrogens. After adjustment for confounders, it was found that higher concentrations of lignans were associated with a reduced risk of death from cardiovascular disease (0.48; 0.24-0.97), whereas higher concentrations of isoflavones (2.14; 1.03-4.47) and daidzein (2.05; 1.02-4.11) were associated with an increased risk. A reduction in all-cause mortality was observed for elevated concentrations of lignans (0.65; 0.43-0.96) and enterolactone (0.65; 0.44-0.97). Utilizing PLCO data and dietary phytoestrogens, Cox proportional hazards regression examined the associations between dietary phytoestrogens and the risk of prostate cancer incidence. After adjustment for confounders, a positive association was found between dietary intake of isoflavones (1.58; 1.11-2.24), genistein (1.42; 1.02-1.98), daidzein (1.62; 1.13-2.32), and glycitein (1.53; 1.09-2.15) and the risk of advanced prostate cancer. Conversely, an inverse association existed between dietary intake of genistein and the risk of non-advanced prostate cancer (0.88; 0.78-0.99) and total prostate cancer (0.90; 0.81-1.00). C-reactive protein (CRP) concentration levels rise in response to inflammation and higher levels are a risk factor for some cancers and cardiovascular disease reported in epidemiologic studies. Logistic regression performed on NHANES data evaluated the association between CRP and urinary phytoestrogen concentrations. Higher concentrations of total and individual phytoestrogens were associated with lower concentrations of CRP. In summary, dietary intake of some phytoestrogens significantly modulates prostate cancer risk and cardiovascular disease mortality. It is possible that these associations may be in part mediated through the influence of phytoestrogen intake on circulating levels of C-reactive protein.
Nayvelt, Irina. "Molecular aspects of antiestrogen resistance and autophagy in breast cancer cells". 2009. http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.000051386.
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