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Artykuły w czasopismach na temat "Produits naturels – Dérivés"
GALTIER, P., I. P. OSWALD, P. GUERRE, D. MORGAVI, H. BOUDRA i J. P. JOUANY. "Le risque mycotoxique : danger et impact sanitaire en productions animales". INRAE Productions Animales 21, nr 1 (20.03.2008): 107–16. http://dx.doi.org/10.20870/productions-animales.2008.21.1.3381.
Pełny tekst źródłaLagrange, Sophie, Christine Roubert i Jidong Zhang. "Les séquanamycines, puissants macrolides oraux anti-tuberculeux dérivés d’un produit naturel". médecine/sciences 39, nr 8-9 (sierpień 2023): 599–602. http://dx.doi.org/10.1051/medsci/2023091.
Pełny tekst źródłaCottencin, O. "Actualités sur les nouvelles drogues de synthèse". European Psychiatry 30, S2 (listopad 2015): S58—S59. http://dx.doi.org/10.1016/j.eurpsy.2015.09.163.
Pełny tekst źródłaNabeneza, Serge, Vincent Porphyre i Fabrice Davrieux. "Caractérisation des miels de l’océan Indien par spectrométrie proche infrarouge : étude de faisabilité". Revue d’élevage et de médecine vétérinaire des pays tropicaux 67, nr 3 (27.06.2015): 130. http://dx.doi.org/10.19182/remvt.10181.
Pełny tekst źródłaOyeniyi, F. G., i E. O. Ewuola. "A review of strategies aimed at adapting livestock to volatile climatic conditions in Nigeria". Nigerian Journal of Animal Production 48, nr 4 (8.03.2021): 79–93. http://dx.doi.org/10.51791/njap.v48i4.3018.
Pełny tekst źródłaGaspar, Thomas, Claude Penel i Hubert Greppin. "Approche analogique et réalités des phytohormones : des retards et des erreurs stratégiques?" Bulletin de la Société Royale des Sciences de Liège, 2016, 190–208. http://dx.doi.org/10.25518/0037-9565.6236.
Pełny tekst źródłaRozprawy doktorskie na temat "Produits naturels – Dérivés"
Bouraiou, Abdelmalek. "Synthèse d'hétérocycles quinoléiques à visée thérapeutique et d'analogues structuraux de produits naturels". Rennes 1, 2009. http://www.theses.fr/2009REN1S126.
Pełny tekst źródłaThis manuscript describes the preparation of new quinolines derivatives associated to heterocycles eg. Aziridine, pyrrolidine or pyrrole and some structural analogues of flavanones, flavonols and tetrahydroquinolones. In this context, we have developed two methods. The first one consists on the generation of the N-metalated azométhine ylide from a -iminoesters in presence of LiBr in basic medium. The second one is based on the thermolysis of the N-alkylaziridine, which react with DMAD to offer N-alkylpyrroles and Delta-pyrrolines. In second part, we have reported the synthesis of new heterocyclic compounds with likely flavonoïd structures incorporating a quinoline unit, from the corresponding 2-hydroxy and 2-aminochalcones. These intermediates were utilized for the preparation of some new compounds that have a similar structure of flavanones, flavonols, 3-hydroxy-2,3-dihydroquinolin-(4)-ones. A new synthetic approach concerning the preparation of 1,2,3,4-tetrahydroquinolin-(4)-one derivatives through an intramolecular cyclization using a microwave irradiation have used with success
Moreau, Anne Madeleine. "Synthèse de produits naturels articulés autour du noyau isoindolinone". Lille 1, 2004. http://www.theses.fr/2004LIL10023.
Pełny tekst źródłaBrajeul, Solenn. "Produits naturels terpenoïdes dérivés d'acylphloroglucinols : travaux exploratoires en vue de la synthèse du xanthochymol et de ses analogues". Paris 11, 2005. http://www.theses.fr/2005PA112288.
Pełny tekst źródłaXanthochymol and guttiferones E and F are polyisoprenylated acylphloroglucins which inhibit the desassembly of miciotubules into tubulin. We have a project of total synthesis of these molecules using biogenesis hypothesis. Firstable, some studies about biomimetic synthesis have been done. Preparation of benzoylphloroglucinol has been studied. Then, prenylation under mild conditions using sulfonium salts have been studied. Finally some original electrophilic aromatic substitution have been developped using these salts. In a second part, the construction of the bicyclic moiety has been studied which has given several prenylated intermediairies. The synthesis of a polyprenylated β-ketoester has allowed the study of several methods to synthesize the bicycle. We observed great difficulties to get the bicycle due to the important steric hinderance mostly due to the gem-dimethyle. The synthesis of a diprenylated cyclohexanone should be usefull for the next studies. Finally the activity towards assembly or disassembly of microtubules has been studied for all the intermediary compounds
Billaud, Célia. "Approche synthétique de la norbadione A : nouvelle préparation d'alcools à partir de sulfones et de dérivés borés". Paris 11, 2005. http://www.theses.fr/2005PA112222.
Pełny tekst źródłaThe synthetic approach of norbadione A, a pigment from mushrooms related to pulvinic acids, was studied. This compound has the property to complex caesium and has shown an antioxidant activity. The first strategy, based on a double Suzuki-Miyaura coupling between a naphtholactone with two boron functions and two pulvinic moieties with a triflate was unsuccessful and has shown a deactivating effect of the lactone. Modifications aimed to inhibit the electro-attracting character of the lactone permitted to obtain a bis(coupled) product with a poor yield. A second approach based on a the cyclisation of enol arylacetates was studied in order to build the pulvinic moiety in several steps. The important reaction of introduction of an alkylacetate from a triflate was realised by a palladium-mediated coupling. The cyclisation attempts carried out using a naphthalenic compound allowed us to isolate a mono-cyclised product. A parallel study was to first build a tetronic moiety and then to construct the exocyclic double bond by a method developed in the laboratory for the preparation of an iodated pulvinic compound. Finally, a new preparation of alcohols from sulfones and boron compounds was developed. Two known reactions in the chemistry of boron were combined. The first one is the reaction between anions of sulfones and trialkylboranes, the second one is a thermal isomerisation which places the boron atom in a terminal position. A new preparation of primary alcohols was thus carried out
Rys, Véronique Angélique. "1(2H)-isoindolinones, points d'ancrage pour l'élaboration de produits naturels et-ou à activité biologique". Lille 1, 2003. https://pepite-depot.univ-lille.fr/RESTREINT/Th_Num/2003/50376-2003-163.pdf.
Pełny tekst źródłaJida, Mouhamad. "Réaction de kulinkovich sur des esters dérivés d'aminoacides naturels et non naturelsApplication à la synthèse de précurseurs potentiels de produits biologiquement actifs". Paris 11, 2008. http://www.theses.fr/2008PA112126.
Pełny tekst źródłaThis thesis is devoted to the study of the intramolecular Kulinkovich cyclopropanation of esters prepared from natural and unnatural aminoacids. The reactions were performed with Grignard reagents in the presence of catalytic or stoechiometric amounts of titanium isopropoxide. The first chapter shows the scope of the Kulinkovich reaction which allows the transformation of esters into cyclopropanols. The reactions were carried out in both inter and intramolecular modes and are extended to cyclic carboxylic derivatives such as lactones, anhydrides, etc… In the second chapter, we study the regio and stereoselectivity of the cyclopropanation reaction when the starting materials possess two ester functions and a terminal double bond. The glutamate derivative furnished expected fused cyclopropanols while the aspartate derivative only gave unexpected pyrrolidinones. In the third chapter, the intramolecular cyclopropanation applied on other alphaaminoesters afforded expected bicyclic cyclopropanols as a mixture of diastereomers, thus providing an access to enantiomerically pure azabicyclo[3. 1. 0]hexanols. The fourth chapter concerns the reactivity of these alcohols under ring opening conditions. The different azabicyclo[3. 1. 0]hexanols were transformed into dihydropyridinones, pyrrolidinones, piperidones or pyridinols , possible precursors of bioactive products. Application of this methodology allowed the preparation of the (S)-2-phenylpiperidin-3-one , a potent intermediate in the synthesis of pharmacologically significant products (substance P antagonists)
Guillier, Fabrice. "Synthèse de produits naturels par association des réactions de métallation et de couplage. Accès à des alcaloïdes marins de type pyridoacridinique". Rouen, 1996. http://www.theses.fr/1996ROUES075.
Pełny tekst źródłaRanaivondrambola, A. Tsiresy. "Synthèse multi-étapes et synthèse parallèle de ligands nicotiniques potentiels : hybrides Anabasine-Lobéline et dérivés de la Sédamine". Nantes, 2012. http://www.theses.fr/2009NANT2148.
Pełny tekst źródłaWe have illustrated in this scientific production some technical aspects of drug discovery with natural substances chemistry and medicinal chemistry. The goal of our work to try bringing scientific contribution to the pharmacology of some targeted receptors, with the synthesis of innovative molecular concepts and ligands from natural piperidines moieties, of lobeline and sedum alkaloids. We then have materialized our efforts in verifying our hypotheses with the development of targeted natural analogues libraries which were biologically evaluated. Several practical techniques, described herein, were used such as linear and parallel synthesis
Sahmim, Wissem. "Modification chimique des extractibles de bois : application à la protection du bois et des matériaux métalliques". Electronic Thesis or Diss., Université de Lorraine, 2018. http://www.theses.fr/2018LORR0300.
Pełny tekst źródłaWithin the framework of this thesis, we are interested in the design, synthesis and characterization of the physicochemical properties of lipophilic derivatives of wood extractives. We have thus considered modifying the structure of three flavonoids whose resource is important from different wood species: catechin, mesquitol and naringenin to incorporate additional functionalities. The applications reported here mainly deal with the protection of materials like wood and corrodible metals. With respect to wood preservation, it seems possible to consider different strategies to inhibit the wood degradation related to fungi on wood. Impregnation of antioxidant compounds such as lipophilic polyphenols on wood can limit the effects of radicals or other oxidants used and generated by rots. The second intended application is the protection of metallic materials. Indeed, the use of natural antioxidants as a corrosion inhibitor replace inorganic inhibitors or organic molecules (polyamines, imidazole...), because their production is expensive and toxic. The grafting of a hydrophobic hydrocarbon chain on polyphenols which have antioxidant properties allows the formation of protective films on the material
Jacques, Isabelle. "Découverte et déchiffrage de nouvelles voies de biosynthèse dépendant des synthases de cyclodipeptides : les clés d’une diversité accrue de dicétopipérazines potentiellement bioactives". Thesis, Paris 11, 2015. http://www.theses.fr/2015PA114838/document.
Pełny tekst źródłaDespite the interest and diversity of the pharmacological properties of 2,5-diketopiperazines (DKPs), the biosynthetic pathways of these microbial molecules are poorly documented. The aim of my doctoral work was i) to identify new DKP biosynthetic pathways that are characterized by the presence of a cyclodipeptide synthase (CDPS) often associated with one or more cyclodipeptide-tailoring enzymes and ii) to explore the chemical diversity encoded by these pathways. First of all, my study focused on CDPSs. After the bioinformatics-based selection of candidates, 51 novel CDPS were characterized, revealing the incorporation of 17 of the 20 proteinogenic amino acids. Moreover, this work has allowed a better characterization of the CDPS family, by showing the existence of several subfamilies with specific functional signatures and laying the foundations of a specificity conferring code for the synthesis of cyclodipeptides. Second, I characterized the tailoring enzymes associated with the newly identified CDPSs and, in particular, the Fe(II) and oxoglutarate dependent dioxygenases (OGs) that are highly represented in these pathways. I detected the in vivo activity for 11 OGs and characterized the in vitro activity for one of them, showing the complexity of the chemical modifications introduced into the cyclodipeptide. This work has led to identify and characterize novel biosynthetic pathways that provide access to a greater diversity of DKPs
Książki na temat "Produits naturels – Dérivés"
1932-, Eckstein Fritz, red. Oligonucleotides and analogues: A practical approach. Oxford: IRL Press, 1991.
Znajdź pełny tekst źródłaOntario. Esquisse de cours 12e année: Sciences de l'activité physique pse4u cours préuniversitaire. Vanier, Ont: CFORP, 2002.
Znajdź pełny tekst źródłaOntario. Esquisse de cours 12e année: Technologie de l'information en affaires btx4e cours préemploi. Vanier, Ont: CFORP, 2002.
Znajdź pełny tekst źródłaOntario. Esquisse de cours 12e année: Études informatiques ics4m cours préuniversitaire. Vanier, Ont: CFORP, 2002.
Znajdź pełny tekst źródłaOntario. Esquisse de cours 12e année: Mathématiques de la technologie au collège mct4c cours précollégial. Vanier, Ont: CFORP, 2002.
Znajdź pełny tekst źródłaOntario. Esquisse de cours 12e année: Sciences snc4m cours préuniversitaire. Vanier, Ont: CFORP, 2002.
Znajdź pełny tekst źródłaOntario. Esquisse de cours 12e année: English eae4e cours préemploi. Vanier, Ont: CFORP, 2002.
Znajdź pełny tekst źródłaOntario. Esquisse de cours 12e année: Le Canada et le monde: une analyse géographique cgw4u cours préuniversitaire. Vanier, Ont: CFORP, 2002.
Znajdź pełny tekst źródłaOntario. Esquisse de cours 12e année: Environnement et gestion des ressources cgr4e cours préemploi. Vanier, Ont: CFORP, 2002.
Znajdź pełny tekst źródłaOntario. Esquisse de cours 12e année: Histoire de l'Occident et du monde chy4c cours précollégial. Vanier, Ont: CFORP, 2002.
Znajdź pełny tekst źródłaStreszczenia konferencji na temat "Produits naturels – Dérivés"
Sonesson, Göran. "Rhetoric from the standpoint of the Lifeworld". W Le Groupe μ : quarante ans de rhétorique – trente-trois ans de sémiotique visuelle. Limoges: Université de Limoges, 2010. http://dx.doi.org/10.25965/as.3106.
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