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1
Dreilich, Martin. "Predictive Factors in Esophageal Carcinoma". Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6831.
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Tibau, Martorell Ariadna. "marcadors biològics predictius de resposta a la quimioteràpia primària (neoadjuvant) amb antraciclines i taxans". Doctoral thesis, Universitat Autònoma de Barcelona, 2016. http://hdl.handle.net/10803/399842.
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Predir la resposta a la quimioteràpia és un repte fonamental en el tractament de pacients amb càncer de mama. El benefici de la quimioteràpia amb antraciclines i taxans en càncer de mama precoç és modest i els efectes secundaris a llarg termini no desdenyables. La identificació de factors predictius de resposta permetria millorar l'eficàcia de la quimioteràpia i minimitzar les toxicitats secundàries. Actualment no disposem de biomarcadors específics per predir la resposta del tumor a la quimioteràpia amb antraciclines i taxans.
L’amplificació del gen Human epidermal growth factor receptor 2 (HER2), la topoisomerasa II alfa (TOP2A) i la duplicació del centròmer del cromosoma 17 (CEP17) s’han proposats com a biomarcadors predictius de resposta a les antraciclines mentre que una expressió disminuïda de la proteïna Tau i dels isotips I a IV de la β-tubulina s’han relacionat amb la resposta a la quimioteràpia amb taxans. Els resultats dels estudis són discordants i cap d’aquests biomarcadors tumorals pot ser considerat un marcador predictiu de resposta a les antraciclines i taxans.
En el present estudi s’han analizat aquests potencials marcadors predictius de resposta al tractament en una cohort de 140 pacients amb càncer de mama estadis II i III tractades amb quimioteràpia neoadjuvant amb antraciclines i taxans, emprant la resposta completa patològica com a marcador subrogat de quimiosensibilitat. Posteriorment s'ha avaluat el seu impacte en la supervivència.
Els resultats d’aquesta tesi demostren: que la duplicació del CEP17 prediu la resposta completa patològica en pacients amb càncer de mama tractades amb esquemes de quimioteràpia basades en antraciclines, i que la baixa expressió de la proteïna Tau s’associa a la resposta a la quimioteràpia neoadjuvant i al benefici amb taxans. Les pacients amb alta expressió de la proteïna Tau tenen millor pronòstic.Predicting response to chemotherapy is a central challenge in treating patients with breast cancer. Anthracycline–taxane-based chemotherapy produces a modest improvement in survival for women with early-stage breast cancer. However, these drugs are associated with serious side-effects and careful selection is needed to ensure that they are given only to patients who may benefit from them. To date, no specific biomarkers have been identified to predict tumor response to anthracycline-taxane-based chemotherapy. Human epidermal growth factor receptor 2 (HER2), topoisomerase II alpha (TOP2A) genes and chromosome 17 centromere enumeration probe (CEP17) duplication have all been proposed as predictive biomarkers of anthracycline treatment, whereas low expression of the microtubule-associated protein Tau and classes I to IV β-tubulin isotypes has been linked to better response to taxane chemotherapy. However, reports are conflicting, and none of these tumor markers can yet be considered a clinically reliable predictor of response to anthracycline–taxane-based chemotherapy. We studied the predictive and prognostic value of TOP2A gene alterations, HER2 gene amplification, CEP17 duplication and Tau protein expression, as well as classes I to IV β-tubulin isotypes expression in 140 patients with operable or locally advanced breast cancer receiving anthracycline-taxane-based neoadjuvant chemotherapy. The results of this thesis show that: CEP17 duplication predicts pathologic complete response to primary anthracycline-based chemotherapy, and low Tau protein expression is associated with response to neoadjuvant chemotherapy and taxane benefit. Patients with high Tau expression have a better prognosis.
3
Hemdan, Tammer. "Prognostic and Predictive Factors in Bladder Cancer". Doctoral thesis, Uppsala universitet, Urologkirurgi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-282607.
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Bladder cancer is a potentially curable malignancy; however in regards to the state of current therapy regimens, a plateau has been reached in both the non-muscle and muscle invasive types. To obtain effective treatment, and consequently a decreased mortality, it has become imperative to test and understand aspects affecting therapy response. The aim of this thesis is to illustrate a better understanding of clinical factors affecting therapy response using new drug combinations and new tumor markers alongside established risk criteria. In Paper I we reported the 5 year follow up from a multicenter, prospectively randomized study and we evaluated the 5-year outcomes of BCG alone compared to a combination of epirubicin and interferon-a2b in the treatment of patients with T1 bladder cancer. Treatment, tumor size and tumor status at second resection were independent variables associated with recurrence. Concomitant Cis was not predictive of failure of BCG therapy. Independent factor for treatment failure was remaining T1 stage at second resection. In Paper II &III we investigated the validity of emmprin, survivin and CCTα proteins as biomarkers for response and survival before neoadjuvant cisplatin chemotherapy. Bladder tumor specimens were obtained before therapy from a total of 250 patients with T1-T4 bladder cancer enrolled in 2 randomized trials comparing neoadjuvant chemotherapy before cystectomy with a surgery only arm. Protein expression was determined by immunohistochemistry (IHC). Patients in the chemotherapy cohort with negative emmprin and CCTα expression had significantly better overall survival (OS) than those with positive expression. In Paper IV primary end point was examining STMN1 as prognostic factor in bladder cancer. Analysis was performed on three bladder cancer patient cohorts using IHC, western blot and a bladder cancer cell line. High levels of STMN1, expression correlated to shorter disease-specific survival and the growth and migration of the cells were significantly reduced when transfecting the cells with STMN1 siRNA. Conclusion Risk assessment and predictors of outcomes could help in individualized treatment and follow up. Biomarkers will become more important for treatment choices in bladder cancer management.
4
Derwinger, Kristoffer. "Prognostic and predictive factors in colorectal cancer /". Göteborg : Dept. of Surgery, Sahlgrenska University Hospital/Östra, 2009. http://hdl.handle.net/2077/19365.
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Robinson, Teresa Michelle. "Predictive Factors of Compassion Fatigue Among Firefighters". ScholarWorks, 2016. https://scholarworks.waldenu.edu/dissertations/2332.
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Few existing studies have examined compassion fatigue among emergency responders even though firefighters and emergency medical service (EMS) professionals have repetitive direct exposure to traumatic events. This study focused on identifying predictor variables for the development of compassion fatigue in firefighters. Karasek's demand-control model, a commonly used work stress model, was the study's theoretical framework as it focuses on specific construct interactions that predict employee well-being. Accordingly, this correlational study examined the predictive nature of EMS license level, years of service, and personality type on the development of compassion fatigue in career firefighters. Data collection occurred with surveys incorporating the Professional Quality of Life Scale and the Big Five Inventory. Mid-Michigan fire departments participated with 129 career firefighters returning completed surveys with results analyzed using logistic regression. Findings revealed a significant predictive relationship between personality traits and the development of compassion fatigue. These findings can inform preventative measures that protect the psychological well-being of these emergency responders by informing and educating the professionals and organizations as to who is at greatest risk and ultimately providing opportunity for risk mediation.
6
Vanichbuncha, Tita. "Risk Factors and Predictive Modeling for Aortic Aneurysm". Thesis, Linköpings universitet, Statistik, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-80391.
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In 1963 – 1965, a large-scale health screening survey was undertaken in Sweden and this data set was linked to data from the national cause of death register. The data set involved more than 60,000 participants whose age at death less than 80 years. During the follow-up period until 2007, a total of 437 (338 males and 99 females) participants died from aortic aneurysm. The survival analysis, continuation ratio model, and logistic regression were applied in order to identify significant risk factors. The Cox regression after stratification for AGE revealed that SEX, Blood Diastolic Pressure (BDP), and Beta-lipoprotein (BLP) were the most significant risk factors, followed by Cholesterol (KOL), Sialic Acid (SIA), height, Glutamic Oxalactic Transaminase, Urinary glucose (URIN_SOC), and Blood Systolic Pressure (BSP). Moreover, SEX and BDP were found as risk factors in almost every age group. Furthermore, BDP was strongly significant in both male and female subgroup. The data set was divided into two sets: 70 percent for the training set and 30 percent for the test set in order to find the best technique for predicting aortic aneurysm. Five techniques were implemented: the Cox regression, the continuation ratio model, the logistic regression, the back-propagated artificial neural network, and the decision tree. The performance of each technique was evaluated by using area under the receiver operating characteristic curve. In our study, the continuation ratio and the logistic regression outperformed among the other techniques.
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Houston, Kelly Charlene. "Maternal prenatal attachment : the role of predictive factors". Thesis, University of Sheffield, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.421025.
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Hupperets, Pierre Stefanus Gerardus Johannes. "Prognostic and predictive factors in primary breast cancer". Maastricht : Maastricht : Universitaire Pers Maastricht ; University Library, Maastricht University [Host], 1995. http://arno.unimaas.nl/show.cgi?fid=8354.
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Enthoven, Paul. "Back pain : long-term course and predictive factors /". Linköping : Linköpings universitet, 2005. http://www.bibl.liu.se/liupubl/disp/disp2005/med881s.pdf.
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Adlard, Julian Weldon. "Colorectal cancer : predictive factors for response to chemotherapy". Thesis, University of Leeds, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.415610.
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Subramanyam, Rajeev. "Factors Predictive of Adverse Postoperative Events Following Tonsillectomy". University of Cincinnati / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1384869860.
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Gilchrist, Randy A. "Factors Predictive of Commitment to Invest in Marriage". DigitalCommons@USU, 1999. https://digitalcommons.usu.edu/etd/2720.
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Research for this thesis investigated factors predictive of how committed married couples are to make positive efforts for their marriage. Respondents consisted of 72 husbands and wives from a semi-urban area. For each gender, correlations were conducted between marital commitment to invest and egalitarian ism, decision-making power, and conflict communication style. Finally, regress ions were conducted with these measures and nine demographic variables.
As projected, commitment to invest in marriage correlated negatively with husband demand-withdrawal communication and positively with husband and wife mutually constructive communication. The stepwise regression predicting husband commitment to invest included demand-withdrawal communication and total months knowing one's spouse. For wives, the regress ion consisted of mutually constructive communication. Finally, the couple regress ion included mutually constructive communication and total months knowing one's spouse. The main implication of this thesis is that conflict communication styles may be assessed for and incorporated into marital therapy because of their possible saliency with commitment to invest.
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Zoli, Matteo <1983>. "Predictive Factors of Biological Behaviour in Pituitary Adenoma". Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2019. http://amsdottorato.unibo.it/8761/1/Zoli_Matteo_Tesi.pdf.
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Background: Predicting biological behavior of pituitary adenomas is a complex but highly desirable issue for both scientific and practical porpoises. Recently, a clinico-pathological grading based on histopathological and neuroradiological features has been proposed, stratifying the risk of progression/recurrence in 5 classes.
Aim of our study is to perform an independent external validation of this score and identify other potential predictor of aggressive behaviour.
Results: Five hundred sixty-six patients with pituitary adenomas were included in this study (253 FSH/LH, 147 GH, 85 PRL, 72 ACTH and 9 TSH tumors). In 437 cases, pituitary adenomas were non-invasive, with low (grade 1a: 378 cases) or high (grade 1b: 59 cases) proliferative activity. In 129 cases, tumors were invasive, with low (grade 2a: 87 cases) or high (grade 2b: 42 cases) proliferative activity. During the follow-up (mean: 5.8 years), 60 patients developed disease recurrence or progression, with a total of 130 patients with pituitary disease at last follow-up. Univariate analysis demonstrated a significantly higher risk of disease persistence and recurrence/progression in patients with PRL, ACTH and FSH/LH tumors as compared to those with somatotroph tumors, and in those with high proliferative activity (grade 1b and 2b) or >1 cm diameter. Multivariate analysis confirmed that tumor type and grade are independent predictors of disease free-survival and progression free-survival. Tumor grading resulted the first parameter emerging in the decision tree analyses with CHAID growing process to stratify patients according to the risk of recurrence/progression.
Conclusions: Our data confirmed the validity of Trouillas’ score, being tumor type and grade independent predictors of disease evolution. Therefore, we recommend to always consider both features, together with tumor histological subtype, in the clinical setting to early identify patients at higher risk of an aggressive behaviour.
14
Cole, Elaine. "Characterising factors predictive of infection in severely injured patients". Thesis, Queen Mary, University of London, 2015. http://qmro.qmul.ac.uk/xmlui/handle/123456789/7975.
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Infection after trauma complicates the patients clinical course. Infection leads to longer critical care and hospital stays, has been associated with increased mortality rates and places considerable cost pressures on health economies. The predictors of infection after severe injury are not known, and the effects on outcomes other than mortality are under-reported. The overall objective of this research was to characterise factors predictive of infection in severely injured patients admitted to critical care. A prospective cohort study of 271 patients investigated admission factors predictive of the development of infection. A second study of 280 patients evaluated post-injury immune cell changes and the association with infection. Thirdly the relationship between early coagulopathy and infections was investigated in 158 patients. Finally a study of 385 patients examined the use of Tranexamic Acid (TXA) and its association with infection and other outcomes. Infection was a significant burden for severely injured patients. Admission hypoperfusion was the only early characteristic associated with the development of infection, and a dose dependent relationship was observed between severity of shock and increased percentage of infection (p<0.01). Lymphopenia prolonged to day four post injury was strongly predictive infection (OR 0.10, CI 0.02-0.48, p<0.01). At 24 hours, the anticoagulant Protein C was lower in those with infection (Infection: 70.2 iu/dL vs. No infection: 83.3 iu/dL p=0.02), and increased fibrinolysis was also associated with infectious complications (Infection: 6156 μg/L vs. No infection: 3324 μg/L p=0.03). There was a trend to a beneficial relationship between TXA and infection, and it was independently associated with reduced organ failure (OR 0.27, CI: 0.10 – 0.73, p=0.01) and mortality (OR 0.16 CI 0.03 - 0.86, p=0.03). In severely injured patients, admission shock, prolonged lymphopenia and early coagulation dysfunction post severe injury were independent predictors of infection. Timely modulation of these responses after trauma may help to reduce the burden of infection.
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Sheard, Mary Kathryn. "A study of possible predictive factors in beginning reading". Thesis, Sheffield Hallam University, 1985. http://shura.shu.ac.uk/20355/.
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The possible contribution of the study lies in its reassessment at the Reading Readiness concept, away from traditional pre-reading training programmes towards an emphasis on the acquisition of print-specific concepts and skills within the context of meaningful reading, whereby the beqinner reader appears best served by a combination of holistic and elements appruaches to the teaching of reading.
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Torres, Palma William Ignacio, i Galaz Mirta Margarita Flores. "Predictive factors of subject well-being in older people". Pontificia Universidad Católica del Perú, 2017. http://repositorio.pucp.edu.pe/index/handle/123456789/123824.
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This study assessed the effect of variables such as life satisfaction, self-rated health, social support and coping styles on subjective well-being. The level of subjective well-being was studied in a sample of Mexican elderly persons from the state of Yucatan in Merida (n = 122) with an age range of 60-93 years. The results in women show that coping styles predicts subjective well-being in negative affects. Moreover, self-perception of health, coping styles, and satisfaction with life are adequate predictors of the cognitive dimension of subjective well-being. Results in men show that satisfaction with life and coping styles predict the cognitive dimension of subjective well-being. Findings point to the importance of exploring psychosocial variables in older adults.El presente estudio evaluó el efecto de las variables satisfacción con la vida, autopercepción de salud, apoyo social y estilos de enfrentamiento sobre el bienestar subjetivo. Se contó con una muestra de 122 adultos mayores mexicanos del Estado de Yucatán, en la ciudad de Mérida con un rango de edad de 60 a 93 años. Los resultados en mujeres muestran que los estilos de enfrentamiento son predictores del bienestar subjetivo en los afectos negativos. En cuanto a la dimensión cognitiva del bienestar subjetivo, la autopercepción de salud, los estilos de enfrentamiento y la satisfacción con la vida fueron predictores adecuados. En hombres, los resultados demuestran que la dimensión cognitiva del bienestar subjetivo fue predicha a partir de la satisfacción con la vida y los estilos de enfrentamiento. Los hallazgos muestran la importancia del profundizar y promover variables psicosociales en los adultos mayores.
Cette étude a évalué l’effet de la satisfaction de la vie, de l’auto-perception de la santé, du soutien social et des styles d’adaptation sur les variables de bien-être subjectif. Nous avons étudié le niveau de bien-être subjectif d’un échantillon de 122 Mexicains âgés de l’État du Yucatan, dans la ville de Mérida, âgés de 60 à 93 ans. Les résultats chez les femmes montrent que les styles d’adaptation sont des facteurs prédictifs du bien-être subjectif des affects négatifs, en termes de la dimension cognitive du bien-être subjectif, l’auto-perception de la santé, les styles de confrontation et de satisfaction avec la vie étaient des prédicteurs adéquats, tandis que chez les hommes, les résultats montrent que la dimension cognitive du bien-être subjectif est prévu de satisfaction de la vie et les styles d’adaptation. Les résultats montrent l’importance d’approfondir et de promouvoir les variables psychosociales chez les personnes âgées.
Este estudo avaliou o efeito de variáveis, satisfação com a vida, autopercepção de saúde, apoio social e estilos de coping no bem-estar subjetivo. o nível de bem-estar subjetivo foi estudado no estado de uma amostra de adultos mexicanos mais antiga do Yucatan em Merida (n = 122) com uma faixa etária de 60-93 anos. Os resultados em mulheres mais antiga mostram que os estilos de enfrentamento são preditores de bem-estar subjetivo em efeito negativo em termos da dimensão cognitiva do bem-estar de saúde subjetiva auto-avaliação, estilos e satisfação com a vida de enfrentamento foram preditores adequados em homens mais antiga resultados mostram que a dimensão cognitiva do bem-estar subjetivo está previsto a partir de satisfação com a vida e estilos de enfrentamento.
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Moskowitz, Chaya S. "Quantifying and comparing the predictive accuracy of prognostic factors /". Thesis, Connect to this title online; UW restricted, 2002. http://hdl.handle.net/1773/9610.
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Jordan, Shannon. "Predictive Factors of Drug Court Completion for Female Participants". ScholarWorks, 2019. https://scholarworks.waldenu.edu/dissertations/7811.
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Women comprise one of the fastest growing populations of the criminal justice system, yet little research exists concerning the success of these women completing a coed pretrial drug court diversion program. Trauma theory was applied to inform the variables in this quantitative correlational study. The predictive nature of age, educational level, marital status, violent criminal history, and mental health problems for women were examined in relation to completion of a coed pretrial drug court diversion program. A convenience sample from secondary, archival data was obtained from a criminal justice agency in Washington, DC. The dataset included women who participated in the program between January 1, 2009 and December 31, 2014. Logistic regression models were used to predict the likelihood of whether these women completed drug court and determine which independent variables were likely to increase or decrease the probability of program completion. Results of the study failed to yield statistically significant relationships between the variables examined. However, the findings indicate possible relationships between marriage and drug court completion, and postsecondary education and drug court completion, which require additional research. Implications for positive social change are drawn for other criminal justice agencies, drug courts, and administrators for enhancing program delivery and reducing women's recidivism.
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Wood, Brian. "A prospective multidisciplinary study of falls in Parkinson's disease". Thesis, University of Aberdeen, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.288276.
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Introduction. Despite being thought of as common and having serious consequences, falls have not been extensively studied in Parkinson’s disease (PD). Prior to this study commencing there were no published large-scale prospective studies looking at the risk factors for falls in PD. This study aimed to accurately establish the incidence of falls in PD and investigate predictive risk factors for fallers from baseline data in all patients known to a district general hospital PD service. In addition cardiovascular investigation, autonomic function and osteoporosis in PD were assessed. Methods. Baseline data was gathered on a cohort of 109 patients with idiopathic PD and the number of falls prospectively ascertained over the following year. The multidisciplinary baseline assessment included historical data, disease specific rating scales, physiotherapy assessment, tests of visual, cardiovascular and autonomic function and bone densitometry. Results. Falls occurred in 68.3% of the subjects. Previous falls, disease duration and loss of armswing were independent predictors of falls and recurrent falls. There were also statistically significant associations between disease severity, balance impairment, depression cognitive impairment and falling. Males were more likely to suffer from recurrent falls. Cardiovascular disorders, autonomic dysfunction and osteoporosis were also highly prevalent but not associated with falls. Conclusions. Falls are a common problem in PD. Some of the risk factors are potentially modifiable. Although there are intrinsic factors inherent to PD that can cause falls, patients with PD that fall should be thoroughly assessed to look more closely at the reason for falling in those individuals. Potential primary prevention of falls should be considered in all patients with PD. In the future, multi-centre intervention studies will be necessary to further investigate potential methods of decreasing falls and their effects in PD.
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Tan, Sanzhi, i 谭三智. "Bronchopulmonary dysplasia in critically ill infants : incidence and predictive factors". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/206959.
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Background:
In the past few decades, with increasing advances in neonatology, more preterm infants have survived. In developed countries, about 12% - 42% of surviving very low birth weight (VLBW) infants developed bronchopulmonary dysplasia (BPD). This chronic lung disease is a severe health burden for both the family and public health resources, and presents several challenges to clinicians and public health practitioners. In the Guangdong province of China, there is no reliable data and research on BPD.
Objective:
This study aimed to assess the incidence and the epidemiological profile of BPD, as well as possible risk factors of BPD in a Guangdong provincial transportation network for critically ill neonates.
Methods:
This was a retrospective cohort study. Data on all VLBW infants (birth weight ≤ 1500g) who were admitted to the neonatal intensive care unit (NICU) of Guangdong Provincial Women and Children’s Hospital (GDWCH) from Jan. 1st 2013 to Dec.31st 2013 were collected from medical records of GDWCH (n=168). The incidence rate of BPD was estimated, and associations with demographic characteristics, maternal characteristics and factors related to clinical practice were described and assessed by univariate analysis and multivariate regression analysis with stepwise (backward) method. At last, a logistic regression model was adopted to predict the potential risk factors for BPD.
Results:
The incidence rate of BPD in VLBW infants in this transportation network for critically ill infants during the study period was 44.6 cases per 100 person-years [95% confidence interval (CI) 40.8 - 48.4 cases per 100 person-years] based on the National Institute of Child Health and Human Development’s (NICHD) definition of BPD. Overall, infants with gestational age (GA) < 30 weeks were more likely to develop BPD [adjusted odds ratio (OR) 4.64; 95% CI 1.97, 10.89], compared to the infants with GA ≥ 30 weeks. Infants diagnosed with asphyxia (adjusted OR 2.78; 95% CI 1.08, 7.18) and infants who received endotracheal tube (ETT) ventilation ≥ 1 day (adjusted OR 3.90; 95% CI 1.33, 11.39) also had higher risk of BPD. On the other hand, female infants were less likely to develop BPD than male infants (adjusted OR 0.37; 95% CI 0.16, 0.87). Predictors for the development of BPD were infants with GA < 30 weeks, male gender, asphyxia and ETT ventilation ≥ 1 day.
Conclusion:
The results of this study suggest that the prevention of prematurity may contribute to a decrease in the incidence of BPD. Improvement on strategies of supplemental oxygen and mechanical ventilation could potentially lower risk in preterm infants. Further study could focus on clinical practice as well as administrative implementation on neonatology, in order to improve healthcare services.published_or_final_version
Public Health
Master
Master of Public Health
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Morland, T. "The predictive factors of subjective recovery in first-episode psychosis". Thesis, University College London (University of London), 2007. http://discovery.ucl.ac.uk/1444858/.
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Conceptualisations of recovery from psychosis have evolved over time, from medically defined models of symptom reduction, to more recent definitions of subjective recovery. First-episode psychosis (FEP) individuals present as a group who are in the early stages of adjustment to the experience of a psychotic illness. Due to the typically early age of onset, they are also in the process of adjusting to major life and role changes. This paper addresses how recovery from FEP has been conceptualised and measured in the literature, and focuses on the validity of applying such measures and concepts specifically to an FEP group.;Key terms: First episode psychosis, subjective recovery, recovery and early intervention in psychosis.
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Lefumat, Hannah. "Interlimb transfer of sensorimotor adaptation : predictive factors and underlying processes". Thesis, Aix-Marseille, 2016. http://www.theses.fr/2016AIXM4014/document.
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L’adaptation motrice renvoie à la capacité de notre système nerveux à produire continuellement des mouvements précis et ce malgré le fait que notre environnement ainsi que notre corps puissent être soumis à des modifications. Le transfert d’adaptation entre les membres découle de notre habilité à généraliser ce que l’on a appris, par exemple, avec un bras au bras opposé. Le transfert entre les membres est un objet d’étude complexe. Les conditions amenant au transfert sont largement débattues dans la littérature car les résultats d’une étude à l’autre peuvent être contradictoires. Ce travail de thèse s’inscrit dans une tentative d’apporter une explication concernant l’hétérogénéité des performances et les divergences observées dans les différentes études portant sur le transfert entre les membres. Les deux premières expériences avaient pour but d’identifier si des conditions paradigmatiques ou idiosyncratiques pouvaient influencer les performances du transfert au bras opposé. L’objectif de la troisième expérience était d’étudier l’influence des processus sous-jacents à l’adaptation sur le transfert entre les membres d’après le modèle de Smith et collaborateurs (2006). Nos résultats nous ont permis d’éclaircir certains aspects du transfert concernant les facteurs prédictifs et les processus mis en jeu. Nos deux premières études suggèrent que les différences individuelles sont une source d’information pertinente pour expliquer certains comportements tels que le transfert entre les membres. Notre troisième étude nous a permis de caractériser les processus qui, durant l’adaptation, prédisposent au transfertMotor adaptation refers to the capacity of our nervous system to produce accurate movements while the properties of our body and our environment continuously change. Interlimb transfer is a process that directly stems from motor adaptation. It occurs when knowledge gained through training with one arm change the performance of the opposite arm movements. Interlimb transfer of adaptation is an intricate process. Numerous studies have investigated the patterns of transfer and conflicted results have been found. The attempt of my PhD project was to identify which factors and processes favor interlimb transfer of adaptation and thence may explain the discrepancies found in the literature. The first two experiments aimed at investigated whether paradigmatic or idiosyncratic features would influence the performance in interlimb transfer. The third experiment provided some insights on the processes allowing interlimb transfer by using the dual-rate model of adaptation put forth by Smith et al. (2006). Our results show that inter-individual differences may be a key factor to consider when studying interlimb transfer of adaptation. Also, the study of the different sub-processes of adaptation seems helpful to understand how interlimb transfer works and how it can be related to other behaviors such as the expression of motor memory
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Stukey, Jennifer Kristin. "Predictive Factors of Organizational Support Communication in Volunteer Mentor Retention". ScholarWorks, 2016. https://scholarworks.waldenu.edu/dissertations/1868.
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Research has shown that long-term volunteer retention is critical for sustaining the viability of youth mentoring programs such as Big Brothers Big Sisters (BBBS). Data from recent studies have indicated that volunteers must continue their service for at least 1 year in to have a sustainable effect on the mentee. Results from prior studies have indicated that the support provided by the agency to the volunteer can predict volunteer retention. However, a gap in current literature exists regarding the effect of support communication on volunteer retention. Therefore, the purpose of this quantitative study was to assess the relationship between organizational support, communication, and retention of volunteers in the BBBS agency. The VPM was developed to explain the life cycle of volunteerism and was the theoretical framework for this study. The primary research question examined how well the variables related to organizational support communication predict the likelihood of volunteer retention. This study used secondary data collected by BBBS as part of the support communication process they provide to their volunteers. Results from a logistic regression analysis revealed that the amount of face-to-face contact and the number of match support specialists positively predicted volunteer retention of at least 1 year. Results from this study can contribute to social change by informing best practices on the types of support communication for long-term volunteer retention. Specifically, leaders and managers of volunteer agencies should develop policies and procedures that maximize the amount of face-to-face communication provided to volunteers from the agency.
24
Pennells, Lisa. "Assessing predictive ability using individual participant time to event data from multiple prospective studies : application to cardiovascular disease risk prediction". Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609800.
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Cirauqui, Cirauqui Beatriz. "Factores pronósticos y predictivos de respuesta en pacientes con carcinoma escamoso de cabeza y cuello". Doctoral thesis, Universitat Autònoma de Barcelona, 2021. http://hdl.handle.net/10803/672595.
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Introducció:
Els carcinomes escamosos de cap i coll (CECC) són tumors que es diagnostiquen freqüentment en una fase localment avançada, fet que condiciona un modest pronòstic. Tot i el maneig multidisciplinari, presenten una supervivència global (SG) menor a 40% als 5 anys, deguda a 50-60% de recurrències locals i 20-30% de metàstasi a distància als 2 anys. Per tot això, hi ha una necessitat de detectar biomarcadors que ens ajudin a seleccionar la millor modalitat terapèutica per a cada pacient i a desenvolupar noves estratègies que reverteixin les resistències als tractaments convencionals.
Objectius:
Amb la hipòtesi que els nivells d'expressió de gens implicats en les vies de reparació de l'ADN i l'activació de la via de l'transductor de senyal i activador de la transcripció 3 (STAT3) poden jugar un paper pronòstic i predictiu de resposta a diferents tractaments de CECC, avaluem la correlació dels primers amb l'eficàcia a l'quimioradioteràpia (QRT) amb platí i de la segona amb la de la combinació de paclitaxel i cetuximab.
Material i mètodes:
Per avaluar el primer objectiu, vam determinar els nivells d'expressió d'ARNm dels gens BRCA1, RAP80, proteïna 1 de unió a p53 (53BP1), mediador del punt de control de el dany de l'ADN 1 (MDC1) i RNF8, tots ells relacionats amb la reparació de l'ADN, i els correlacionem amb la resposta i la SG en 72 pacients amb CECC localment avançat (CECC-LA) tractats amb carboplatí setmanal AUC 2 i radioteràpia (RT).
Per avaluar el segon objectiu, analitzem retrospectivament les mostres tumorals disponibles de 52 pacients d'una sèrie amb CECC recurrent / metastàsic (CECC R / M) tractats amb paclitaxel i cetuximab entre 2008 i 2017, i vam determinar els nivells transcripcionals de STAT3, l'expressió de STAT3 fosforilat (pSTAT3) i la hipermetilació de promotor del gen de la fosfatasa T de proteïna tirosina de tipus receptor (PTPRT).
Resultats:
A la primera sèrie, la resposta completa (RC) a la QRT va ser significativament superior en els pacients que tenien tumors amb nivells baixos de 53BP1 en comparació amb aquells amb tumors amb nivells elevats, i s'acompanyava d'una tendència a una millor SG. Per a un petit grup de pacients amb tumors amb baixa expressió de 53BP1 i BRCA1 o RAP80 alt, la taxa de RC encara era superior.
A la segona sèrie, 58,82% dels tumors van presentar metilació de promotor de PRPRT i aquesta es va associar significativament amb una menor taxa de resposta (TR) a paclitaxel i cetuximab. La sobreexpressió de la proteïna pSTAT3 es va detectar en el 66,67% dels tumors i també es va correlacionar amb resistència a el tractament, encara que no es van obtenir diferències significatives.
Conclusions:
En el nostre primer treball vam observar que l'eficàcia de la RT en combinació amb carboplatí en el tractament de CECC-LA es correlaciona amb els nivells d'expressió d'ARNm de 53BP1 i que els nivells d'expressió d'ARNm de BRCA1 i RAP80 semblen reforçar el seu valor predictiu .
En el nostre segon treball, l'activació de la via STAT3, valorada per la sobreexpressió de pSTAT3 i regulada per la metilació de l'promotor de PTPRT, prediu resistència a paclitaxel i cetuximab en CECC R/M.Introducción: Los carcinomas escamosos de cabeza y cuello (CECC) son tumores que se diagnostican frecuentemente en una fase localmente avanzada, hecho que condiciona un modesto pronóstico. A pesar del manejo multidisciplinar, presentan una supervivencia global (SG) menor al 40% a los 5 años, debida a un 50-60 % de recurrencias locales y un 20-30% de metástasis a distancia a los 2 años. Por todo esto, existe una necesidad de detectar biomarcadores que nos ayuden a seleccionar la mejor modalidad terapéutica para cada paciente y a desarrollar nuevas estrategias que reviertan las resistencias a los tratamientos convencionales. Objetivos: Con la hipótesis de que los niveles de expresión de genes implicados en las vías de reparación del ADN y la activación de la vía del transductor de señal y activador de la transcripción 3 (STAT3) pueden jugar un papel pronóstico y predictivo de respuesta a diferentes tratamientos del CECC, evaluamos la correlación de los primeros con la eficacia a la quimiorradioterapia (QRT) con platino y de la segunda con la de la combinación de paclitaxel y cetuximab. Material y métodos: Para evaluar el primer objetivo, determinamos los niveles de expresión de ARNm de los genes BRCA1, RAP80, proteína 1 de unión a p53 (53BP1), mediador del punto de control del daño del ADN 1 (MDC1) y RNF8, todos ellos relacionados con la reparación del ADN, y los correlacionamos con la respuesta y la SG en 72 pacientes con CECC localmente avanzado (CECC-LA) tratados con carboplatino semanal AUC 2 y radioterapia (RT). Para evaluar el segundo objetivo, analizamos retrospectivamente las muestras tumorales disponibles de 52 pacientes de una serie con CECC recurrente/metastásico (CECC R/M) tratados con paclitaxel y cetuximab entre 2008 y 2017, y determinamos los niveles transcripcionales de STAT3, la expresión de STAT3 fosforilado (pSTAT3) y la hipermetilación del promotor del gen de la fosfatasa T de proteína tirosina de tipo receptor (PTPRT). Resultados: En la primera serie, la respuesta completa (RC) a la QRT fue significativamente superior en los pacientes que tenían tumores con niveles bajos de 53BP1 en comparación con aquellos con tumores con niveles elevados, y se acompañaba de una tendencia a una mejor SG. Para un pequeño grupo de pacientes con tumores con baja expresión de 53BP1 y BRCA1 o RAP80 alto, la tasa de RC todavía era superior. En la segunda serie, 58,82% de los tumores presentaron metilación del promotor de PRPRT y ésta se asoció significativamente con una menor tasa de respuesta (TR) a paclitaxel y cetuximab. La sobreexpresión de la proteína pSTAT3 se detectó en el 66,67% de los tumores y también se correlacionó con resistencia al tratamiento, aunque no se obtuvieron diferencias significativas. Conclusiones: En nuestro primer trabajo observamos que la eficacia de la RT en combinación con carboplatino en el tratamiento del CECC-LA se correlaciona con los niveles de expresión de ARNm de 53BP1 y que los niveles de expresión de ARNm de BRCA1 y RAP80 parecen reforzar su valor predictivo. En nuestro segundo trabajo, la activación de la vía STAT3, valorada por la sobrexpresión de pSTAT3 y mediada por la metilación del promotor de PTPRT, predice resistencia a paclitaxel y cetuximab en CECC R/M.
Background: Head and neck squamous cell carcinomas (HNSCC) are tumors that are frequently diagnosed in a locally advanced phase, a fact that determines a bad prognosis. Despite multidisciplinary management, they have a 5-year overall survival (OS) of less than 40%, due to 50-60% local recurrences and 20-30% 2-year distant metastases. For this reason, there is a need to detect biomarkers that help us to select the best therapeutic modality for each patient and develop new strategies to reverse resistance to conventional treatments. Objectives: With the hypothesis that the expression levels of genes involved in DNA repair pathways and the activation of the signal transducer and activator of transcription 3 (STAT3) pathway may play a prognostic and predictive role in response to different HNSCC treatments, we evaluated the correlation of the first ones with the efficacy of chemoradiotherapy (CRT) with platinum and of the second ones with that of the combination of paclitaxel and cetuximab. Material and methods: To evaluate the first endpoint, we determined the mRNA expression levels of the genes BRCA1, RAP80, p53-binding protein 1 (53BP1), mediator of DNA damage checkpoint 1 (MDC1) and RNF8, all of them related to DNA repair and correlated them with response and OS in 72 patients with locally advanced HNSCC (LA-HNSCC) treated with weekly AUC 2 carboplatin and radiotherapy (RT). To evaluate the second endpoint, we retrospectively analyzed the available tumor samples from 52 patients from a series with recurrent / metastatic HNSCC (R / M HNSCC) treated with paclitaxel and cetuximab between 2008 and 2017, and we determined the transcriptional levels of STAT3, the expression of phosphorylated STAT3 (pSTAT3), and the hypermethylation of the receptor-type tyrosine-protein phosphatase T (PTPRT) promoter. Results: In the first series, the complete response (CR) to CRT was significantly higher in patients who had tumors with low levels of 53BP1 compared to those with tumors with elevated levels, and a trend towards better OS. For a small group of patients with tumors with low expression of 53BP1 and high BRCA1 or RAP80 expression, the CR rate was still higher. In the second series, 58.82% of the tumors presented PRPRT promoter methylation and it was significantly associated with a lower response rate to paclitaxel and cetuximab. The overexpression of the pSTAT3 protein was detected in 66.67% of the tumors and was also correlated with resistance to treatment, although no significant differences were reached. Conclusions: In our first work we observe that the efficacy of RT in combination with carboplatin in the treatment of LA-HNSCC is correlated with the levels of expression of 53BP1 mRNA, and that the levels of expression of BRCA1 mRNA and RAP80 seem to reinforce its predictive value. In our second work, the activation of the STAT3 pathway measured by the overexpression of pSTAT3 and mediated by the methylation of the PTPRT promoter predicts resistance to paclitaxel and cetuximab in R / M HNSCC.
Universitat Autònoma de Barcelona. Programa de Doctorat en Medicina
26
Eppes, Susan Elise. "Washington State Ergonomics Tool: predictive validity in the waste industry". Thesis, Texas A&M University, 2004. http://hdl.handle.net/1969.1/547.
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This study applies the Washington State Ergonomics Tool to waste industry jobs in Texas. Exposure data were collected by on-site observation of fourteen different multi-task jobs in a major national solid waste management company employing more than 26,000 employees. This company has nationwide operations, and these jobs represent the majority of workers involved in the collection and processing of solid waste. The WSET uses observational checklist methodology to evaluate generic risk factors in the following six major categories: awkward posture, highly repetitive motion, high hand force, repeated impact, lifting, and hand-arm vibration. The assessment tool incorporates these risk factors and combinations of risk factors into checklists for identifying three levels of potential exposure: safe, -caution zone" and -hazard zone" jobs. The tool was developed for employers to use in determining whether a job was likely to increase the risk of workplace musculoskeletal disorders (WMSDs) to their employees. OSHA 200 logs were used as the main source of morbidity data. If there was one recorded WMSD, the job was classified as -positive. "If there was no recorded WMSD, the job was classified as -negative. "-Safe"jobs were those predicted not to expose workers to increased risk of WMSDs. Those that possessed one or more -caution zone"criteria but still fell below the -hazard zone" threshold required the employer to provide -awareness education" for employees and to further analyze the job for the presence of -hazard zone" risk factors. If hazard zone risk factors were not present, no further action was required. Jobs that upon further analysis possessed one or more of the -hazard zone"criteria were labeled -hazardous" jobs. If the further analysis shows the presence of risk factors established in the hazard zone criteria (Appendix B), the employer would be required to take corrective action to reduce exposures to below the hazardous level. Of the three jobs predicted to be -safe"by -caution zone" criteria, two did not have injuries and one did. Of the eleven jobs predicted by -caution zone"criteria to increase the risk of WMSDs, six resulted in injuries and five did not. Of the four jobs predicted by -hazard zone"criteria to be -problem"jobs, two jobs did result in injury and two did not. This study found that the WSET -caution zone"criteria were more effective at predicting which jobs were likely to increase the risk of WMSDs than was the -hazard zone"checklist. The caution zone had high sensitivity and low specificity. The hazard zone criteria reflect a low sensitivity and a low specificity. Further analysis revealed the WSET was helpful in predicting back injuries associated with lifting but not effective at predicting jobs with the potential for upper extremity injuries.
27
Gjurich, Gregory D. "A predictive model of surface warfare officer retention : factors affecting turnover". Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 1999. http://handle.dtic.mil/100.2/ADA362176.
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Thesis (M.S. in Operations Research) Naval Postgraduate School, March 1999.Thesis advisor(s): William K. Krebs, Samuel E. Buttrey. "MArch 1999". Includes bibliographical references (p. 49-50). Also available online.
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GONCALVES, MARCELO ESTACIO SILVESTRE. "DO BRAZILIAN INDUSTRIES CONTAIN PREDICTIVE INFORMATION FOR THE FAMA-FRENCH FACTORS?" PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2014. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=24934@1.
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Como os retornos das carteiras formadas por ações de setores econômicos brasileiros são utilizados pelos investidores? As informações contidas nesses retornos são capazes de explicar os movimentos das ações brasileiras? O objetivo do presente trabalho é ajudar a responder a essas perguntas ao pesquisar se os
retornos e a volatilidade dos fatores SMB e HML do modelo de três fatores de Fama e French podem ser previstos pelos retornos passados de 16 carteiras formadas por empresas de um mesmo setor econômico listadas na BM&FBOVESPA no período de 1995 a 2012. A análise revela que 14 de 16 setores preveem o retorno do SMB para um mês à frente. Ademais, os retornos de um número significante de setores preveem a volatilidade do SMB e HML para até três meses adiante. Considerando a capacidade explicativa do modelo de Fama e French para o mercado brasileiro, os resultados desta pesquisa indicam que os
retornos setoriais brasileiros contêm informações valiosas para os fatores SMB e HML, demonstrando que os investidores não conseguem absorver todas as informações disponíveis em um tempo hábil, fazendo com que estas se difundam gradualmente no mercado.How are the brazilian industry returns used by investors? Can the information contained in these returns explain the movements of Brazilian shares? The purpose of this work is to help answer these questions by examining whether the returns and the volatility of SMB and HML factors of Fama-French threefactor model can be predicted by past returns of 16 portfolios formed by companies from the same industry listed on São Paulo Stock Exchange (BM&FBOVESPA) between 1995 and 2012. The analysis reveals that 14 of 16 industries predict the SMB returns one month ahead. Furthermore, the returns of a significant number of industries predict the volatility of SMB and HML factors up to three months ahead of time. Considering the explanatory capability of the Fama-French model for the Brazilian market, the results of this research show that Brazilian industry returns contain valuable information for the SMB and HML factors, demonstrating that investors cannot absorb all the information in a timely manner, resulting in their gradual diffusion throughout the market.
29
Mancini, Kathryn J. "Mother-Adolescent Dyadic Affective Flexibility across Interactions: Measurement and Predictive Factors". Miami University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=miami1529685938908801.
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Deighton, Jennifer. "DETERMINING PREDICTIVE FACTORS OF INTENT TO STAY WITHIN THE HOSPITALITY INDUSTRY". Kent State University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=kent1604663882181397.
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Ugwu, Gabriel Ugwuja. "Family Predictive Factors of Rural Malaria Prevalence in Nsukka, Eastern Nigeria". ScholarWorks, 2019. https://scholarworks.waldenu.edu/dissertations/7764.
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Children in early childhood are still suffering from burdens of malaria-related morbidity and mortality. There have been insufficient studies on how family-level factors may predict the prevalence of malaria (PoM), and negatively impact the control of malaria in rural areas, especially among children. In this study, potential family factors were explored to address the challenges associated with the increase in PoM among the children in rural areas of Nsukka. Socioecological framework guided this study at the interpersonal level. The quantitative cross-sectional study used secondary data from Demographic and Health Surveys (DHS) of 2015 in Nsukka rural communities. Data were analyzed using chi-square analysis and multinomial logistic regression. The result showed a statistically significant relationship (P<0.05) between the age group susceptibility among children. There were statistically significant relationships between the family’s ownership of land for agricultural use, the family’s choice of a treatment facility and socioeconomic status. The couple’s extent of effective communication and whether the children in early childhood slept under the mosquito net showed statistically significant results. Positive social change implications depicted organizational level benefit that may help UNICEF and WHO by recruiting representatives in the distribution of preventive, control and treatment of malaria to the rural areas. Empowerment of women in the household to attend to their children during an emergency and standard housing policy initiative such as Family in Children (FIC) address both individual and societal levels, respectively.
32
Limthanakom, Natcha. "A FRAMEWORK FOR UNDERSTANDING STYLE ROTATION IN U.S. EQUITY MARKETS". NSUWorks, 2010. http://nsuworks.nova.edu/hsbe_etd/61.
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In the first essay, I document sample-specific and time period-specific style returns in two distinct sets of U.S. equities: Fama and French style portfolios and the S&P 1500 style indexes. The value and size effects are apparent in the Fama and French portfolios. Only the size effect is evident in the S&P data. In general, the Fama and French style returns are greater than those of the S&P 1500 styles. Style returns tend to be time-varying and exhibit momentum over a variety of formation period-holding period horizons.
In the second essay, I utilize a bootstrap procedure to test for the presence of styleswitchers - as defined in Barberis and Shleifer (2003). I document style winner and loser continuations. There are some periods when no matter which particular style won (lost) in the past, it is more likely to continue winning (losing) in the future. I also test some Barberis and Shleifer (2003) propositions regarding style momentum. One proposition holds that Sharpe ratios from style-level momentum strategies should be at least as large as asset-level momentum Sharpe ratios. While many style momentum strategies generate significant returns, the implied Sharpe ratios are lower than those reported for asset-level momentum strategies. The Barberis and Shleifer (2003) model also suggests that style momentum could be time-varying. I condition style momentum returns on January, lagged market state, lagged monetary policy changes and lagged changes in relative dispersion and find significant conditional style-level momentum.
In the third essay, I identify and test explanatory factors that potentially predict style momentum returns. Several macroeconomic, relative dispersion, market related and volatility related factors are associated with future short-term style momentum returns. Interactions of many of these variables with market and monetary state indicator variables are significant in the
regressions as well.
33
Moore, Patricia B. "Analysis of predictive factors for fully mission capable rates of deployed aircraft". Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 1998. http://handle.dtic.mil/100.2/ADA355707.
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Thesis (M.S. in Operations Research) Naval Postgraduate School, September 1998."September 1998." Thesis adviso(s):Samuel E. Buttrey. Includes bibliographical references (p. 45-46). Also available online.
34
Stark, Lisa Gail. "An investigation of potential novel predictive factors for graft-versus-host disease". Thesis, University of Newcastle upon Tyne, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.401301.
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Ho, Maria Ming Chee. "ABC transporters as predictive factors for chemotherapeutic response in acute myeloid leukemia". Thesis, University of British Columbia, 2007. http://hdl.handle.net/2429/30890.
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Multidrug Resistance (MDR), resistance to multiple chemotherapeutic drugs, is a major problem
in the treatment of acute myeloid leukemia (AML) . Overexpression of members of the ATPBinding-
Cassette (ABC) transporter superfamily has been associated with clinical MDR and
failure of conventional chemotherapy. The work in this thesis was the first in investigating
expression of ABC transporters and functional effects of their modulation in AML subpopulations along the leukemic stem cell hierarchy: CD34+CD38- (primitive and disease
maintaining), CD34+CD38+ (differentiating progenitors), and CD34- (depleted of progenitors).
An initial profiling of mRNA expression of the 47 human ABC transporters in total de novo
blasts by RT Real-Time PCR showed no consistent differences between patients who
subsequently achieved complete remission following conventional remission induction
chemotherapy (responders) and patients who remained refractory (non-responders). Subsequent
profiling of isolated subpopulations, however, revealed elevated expression of MDR1 and/or
BCRP1, two main drug-resistance ABC transporters, in the primitive CD34+CD38- fraction of
7/10 non-responders compared to 0/7 responders. To test their functional activity ex vivo,
daunorubicin sensitivity with or without ABC modulators was determined in AML subpopulations by the apoptotic assay. I found high ABC-dependent drug resistance, correlated
to high MDR1IBCRP1 expression level and reversible by ABC inhibition, in the CD34+CD38-
fraction of non-responders compared to responders. This suggests an active functional role of
ABC transporters in the primitive, disease-maintaining fraction. Taken as a whole, my studies
suggest a prognostic significance of ABC transporters in the primitive CD34+CD38- leukemic
subpopulation, and support a modified approach in investigating the value of ABC modulating
agents in AML. It may be possible to pre-screen and identify patients for whom ABC transporters is a major factor for MDR before initial treatment, who are most likely to benefit
from the combination of conventional chemotherapy and ABC inhibitors. This will be invaluable
especially to patients with a normal karyotype (50% of patients), since cytogenetic aberrations
currently remain the most useful prognostic marker for AML.Medicine, Faculty of
Biochemistry and Molecular Biology, Department of
Graduate
36
Chow, Chin-ying, i 周展盈. "Evaluation of white coat hypertension in Chinese children : predictive factors and outcome". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/193755.
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Objectives
Hypertension is increasingly found in children. 24 hour ambulatory blood pressure monitoring is now preferred to office blood pressure measurement for diagnosis and monitoring. Blood pressure of children tends to fluctuate widely throughout the day and night. A number of children suffer from a condition called white coat hypertension in which elevation of blood pressure is only transient and they usually have normal blood pressure on continuous monitoring. This condition is not totally benign. Some patients will evolve into hypertension over time. This retrospective case control study is to compare the demographic characteristics and blood investigations of these 2 groups namely white coat hypertension cases and a control group so as to identify factors predictive of white coat hypertension in a Chinese population to help allocate resources for timely diagnostic investigation.
Method
100 patients referred from primary health care units aged 6-18 year old for suspected hypertension based on raised office blood pressure measurements were recruited as cases in the white coat hypertension group and 100 age-matched patients as a control group. The factors studied included gender, body mass index, length of gestation, birth weight, family history of hypertension, positive past medical history, blood pressure at first presentation, blood pressure of ambulatory blood pressure monitoring, serum glucose, urate and cholesterol and triglyceride level. Univariate analysis was used to detect significant difference between the cases and the controls for continuous and categorized variables. Logistic regression was used to assess the independent associations of significant predictive factors of white coat hypertension. Correlations with the scatterplots for the relation of office systolic blood pressure and diastolic blood pressure with 24 hour ambulatory blood pressure monitoring within cases was done to see if there was any significant relations. The outcome of cases was also studied for the proportion which progressed into genuine hypertension.
Results
Body mass index (BMI) was identified as a significant predictive factor in logistic regression with an odds ratio of 1.18 (95% CI = 1.11-1.25) with p-value <0.001. The correlation between 24 hour ambulatory blood pressure and office blood pressure measurement was not significant. None of the cases progressed into genuine hypertension upon follow up.
Conclusion
To conclude, this study showed that high BMI might be predictive of white coat hypertension in Chinese children in Hong Kong. This result could be act as a hypothesis for future research. Multi-centre prospective cohort studies might be of value in testing this factor together with factors which were shown to be significant in other studies. White coat hypertension is not always as benign as thought. Obesity is a condition which requires attention from patients, parents, paramedics and healthcare practitioners especially in primary healthcare settings and should be monitored more closely for the emergence of associated complications.published_or_final_version
Public Health
Master
Master of Public Health
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Wells, Stephen Geoffrey. "Factors affecting the storage and reproduction of predictive smooth pursuit eye movements". Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.321997.
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Schreckengost, Renee. "Energy-efficient housing alternatives: a predictive model of factors affecting household perceptions". Diss., Virginia Polytechnic Institute and State University, 1985. http://hdl.handle.net/10919/71258.
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The major purpose of this investigation was to assess the impact of household socio-economic factors, dwelling characteristics, energy conservation behavior, and energy attitude on the perceptions of energy-efficient housing alternatives. Perceptions of passive solar, active solar, earth- sheltered, and retrofitted housing were examined.
Data used were from the Southern Regional Research Project, S-141, "Housing for Low and Moderate Income Families." Responses from 1804 households living in seven southern states were analyzed. A conceptual model was proposed to test the hypothesized relationships which were examined by path analysis.
Perceptions of energy-efficient housing alternatives were found to be a function of selected household and dwelling characteristics, energy attitude; household economic factors, and household conservation behavior. Age and education of the respondent, family size, housing-income ratio, utility-income ratio, energy attitude, and size of the dwelling unit were found to have direct and indirect effects on perceptions of energy-efficient housing alternatives. Energy conservation behavior made a significant direct impact with behavioral energy conservation changes having the most profound influence.
Conservation behavior was influenced by selected household and dwelling characteristics, energy attitude, and household economic factors. Significant effects were found between conservation efforts and age, size, and condition of the housing unit, age and education of respondent, family size, and energy attitude.
Household economic factors were directly affected by selected household and dwelling characteristics. Age and education of respondent and age and condition of dwelling had significant effects on the proportion of monthly income spent for housing and utilities.Ph. D.
39
Culshaw, Mary. "Individuals with Fetal Alcohol Spectrum Disorder: Predictive Factors for Successful Occupational Performance". VCU Scholars Compass, 2015. http://scholarscompass.vcu.edu/etd/4074.
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As awareness and diagnoses of FASD grow in Canada, there is increased need to support these individuals across their lifespan. One study suggested the prevalence of FASD may be as high as 10 per 1000 births (May & Gossage, 2001). The impact to society is growing as well, since this population requires support across their lifespan due to cognitive and sometimes physical impairments. It was estimated that the annual cost to Canadians was $53 billion (in 2007 dollar value) to support individuals aged 0-53 years (Stade et al., 2009). There is mounting evidence identifying the cognitive and physical impairments that these individuals have, particularly in children. Studies have also described the adaptive functioning of children with FASD, and their ability to cope in daily life. There is little information on youth and adults regarding their daily lives, and the factors that contribute to success in daily life. The purpose of this study was to identify predictive factors that contribute to success in occupational performance in youth and adults with FASD. Using the Canadian Model of Occupational Performance and Engagement (CMOP-E), the study explored variables reflecting the person, environment, and activity that promoted engagement and participation. The study also investigated the value of using self-report or performance-based assessment with the FASD youth and adult population. Due to memory, cognitive, and executive functioning deficits, the individual with FASD may not be able to accurately self-report. Results from the study suggest an individual’s living situation, involvement with foster care, and family involvement play a role in successful occupational performance. Formal assessments of cognitive, academic and memory abilities did not appear to play a role in the individual’s school completion and daily life. Interestingly, the characteristics of this FASD sample depicted a group of youth and adults, who, in general, lived with family, had completed some schooling at the grade 10-12 level, had limited employment, were not involved with the judicial system, and were just as likely to be Caucasian as Aboriginal. The concept of occupational performance proved complex, and future study on the factors contributing to occupational performance would benefit from additional variables related to environment and activity than were available in the current data set.
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Rowe, Lynn A. "Predictive Factors of Intensive Care Length of Stay in Liver Transplant Recipients". Diss., The University of Arizona, 2014. http://hdl.handle.net/10150/338685.
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The purpose of this study was to evaluate liver transplant recipient factors associated with postoperative complications leading to longer intensive care unit (ICU) length of stay which in turn may increase hospital morbidity and mortality. A retrospective, correlational design was developed with a sample of 230 participants. Data were collected for liver transplant recipients over a four-year period (June 2007-December 2011) from the electronic medical record and the transplant database. T test and binary logistic regression were used to assess for the factors predictive of ICU complications, ICU length of stay (LOS), hospital length of stay (HLOS), and overall morbidity and mortality. Data were collected from three time periods: preoperatively, intraoperatively, and postoperatively. The factors identified as statistically significant were cold ischemic time, lowest intraoperative glucose, postoperative four-hour blood urea nitrogen (BUN), Postoperative Day 1 (POD 1) hematocrit, postoperative lowest systolic blood pressure, and fresh frozen plasma (FFP) transfusions. Mortality occurred in 1 recipient in the >9-day ICU stay group, and 7 deaths were noted in the >19-day hospital LOS group. Age of recipients who died was 48-59 (6 males, 2 females), with 7 Caucasian and 1 Other. Comorbidities of these deceased recipients were diabetes and obesity with MELD scores of 18-45. Complications experienced by recipients included: 6 with renal failure, 2 with sepsis, 3 with graft dysfunction, and 1 with cerebral edema. Findings from this study showed factors that impact ICU LOS, HLOS, and mortality, including BUN, glucose, and hematocrit. Implications for practice are that these factors should be closely monitored in the pre-, intra-, and postoperative time periods to reduce risks of complications to transplant recipients. Future research should include further evaluation of the factors associated with poor transplant outcomes, including glucose, continuous renal replacement therapy (CRRT) use, age, and gender. Nurse researchers must continue to strive to understand the pathophysiological mechanism of liver disease to reduce ICU complications ultimately to improve the care and outcomes of liver transplant recipients while reducing ICU LOS and HLOS.
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Salters, Jean E. "Predictive Factors of Student Mathematics Achievement Decline Between Third and Fifth Grade". ScholarWorks, 2019. https://scholarworks.waldenu.edu/dissertations/7072.
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Low math achievement among elementary school students is a concern because students who lack a strong early foundation in mathematics may experience difficulty learning in future mathematics classes. Students in 2 rural southeastern school districts demonstrated low math achievement in 5th grade and their scores declined from 3rd to 5th grade. In this quantitative study, teacher-related factors that research has shown to predict student achievement were examined using Bandura's theory of self-efficacy and Ball and McDiarmid's emerging theory of subject matter content knowledge. The research question asked whether the teacher factors, years of teaching experience, hours of professional development in math pedagogy, college math courses completed, math teacher preparation courses, and teaching efficacy, predicted student math achievement in the 2 districts. Data were collected from 29 3rd grade teachers and 32 5th grade teachers and analyzed using binary logistic regression. The findings showed that the combination of predictors did not significantly predict math achievement of 5th grade students. However, teachers who had 1 to 9 years of teaching experience were more likely to have students with higher math achievement than those with more than 20 years of experience (OR = 4.96; p = .048). The inconclusive results indicate that additional factors that might influence students' math achievement have to be explored and additional professional development has to be offered, especially for teachers who have been teaching for 2 decades as they might have learned curriculum and pedagogy different from current practice. Positive social change will occur when all elementary teachers are able to facilitate students' learning of mathematics and the students successfully master math concepts.
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Bennett, Rachel. "Alcohol and drug related offences: Determining predictive factors for reducing re-offending". Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2005. https://ro.ecu.edu.au/theses/1563.
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The association between dependent drug use and criminal behaviour is well known. This coupled with evidence about the efficacy of treatment in addressing drug use has led many jurisdictions to incorporate treatment interventions into their criminal justice systems. The aim of these interventions that use the law as a therapeutic agent (known as ‘therapeutic jurisprudence') is to reduce by mandating drug dependent offenders into treatment, future offending. However, within the treatment effectiveness literature there is also evidence of individuals resolving their drug use problems without engagement in treatment. The term ‘natural recovery’ has been used to describe this phenomenon. Research into the processes involved in natural recovery has led to the development of the concept of Recovery Capital. Recovery Capital refers to an individual's pre-existing access to social, community, physical and interpersonal, resources that facilitate and sustain change. In this research the notion of recovery capital was operationalized into a ! 00 item questionnaire that tapped the domains known to constitute recovery capital, namely Physical, Human, Social and Cultural Capitals. The key innovation of this research was to test out the predictive value of Recovery Capital for re-offending in a cohort of 150 drug related offenders. The impact on outcome of Recovery Capital was compared to other known criminogenic, demographic and drug use factors on the recidivism rates over an 18 month follow up period. The research was driven by four hypotheses. The first of these was that there would be a positive association between levels of Recovery Capital and outcome. This hypothesis was upheld. Not only were the levels of recovery significantly associated with outcome. but it was found that for every one point increment in global recovery capital score the risk of re-offending dropped by 5%. The second hypothesis was that the component parts of recovery capital would not be individually influential in determining outcome. This hypothesis was rejected. Each of the constituent components of recovery capital, namely Social, Physical, Cultural and Human, was significantly associated with outcome. The two strongest predictors were found to be Human and Cultural capitals with a one score increment respectively resulting in a 5.4% and a 9.2% decrease in risk of re-offending. The third hypothesis was that the disposition (sentence) handed down by the court would not influence outcome. This hypothesis was upheld. The court dispositions of court mandated treatment, probation, incarceration, Community service order or a fine had no impact on re-offending. The final hypothesis was that recovery capital, when compared to other potential predictive variables would be the strongest predictor. This hypothesis was upheld in that recovery capital. W\hen analysed using multivariate regression, was found, along with age to be the best predictor of outcome. Persons with high, as opposed to low, levels of recovery capital were 80%, less likely to re-offend. The implications of these findings arc that the social embeddedness of an individual, rather than any clinical or judicial intervention, is critical in determining the risk of re-offending. As such recovery capital merits greater investigation and acknowledgement, as a criminogenic variable.
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Wallin, Ulrik. "Cancer of the Colon and Rectum : Prognostic Factors and Early Detection". Doctoral thesis, Uppsala universitet, Kolorektalkirurgi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-159142.
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Colorectal cancer (CRC) is one of the most common causes of death from malignant disease. Nevertheless, no ideal screening method exists and there is a lack of prognostic and predictive factors to support clinical decisions and to aid the development of a more individualized treatment for patients with CRC. The aim of this thesis was to investigate early detection, prognostic and predictive factors of CRC. In the first paper, a novel method to collect cells for DNA quantification from the rectal mucosa was investigated. The sensitivity and specificity of this test to detect CRC or any pathology in colon and rectum were ultimately too low to be acceptable. In the second paper, the prognostic value of growth differentiation factor 15 (GDF 15) was evaluated in patients curatively operated for colorectal cancer. GDF 15 expression was demonstrated to be associated with a negative prognosis in patients with stages I-III and III disease. In the third paper, the prognostic value of BRAF, PIK3CA KRAS and MSI was evaluated in a cohort of patients with CRC stratified by disease and recurrence. The results indicated that patients with CRC stage III without recurrence have a higher frequency of BRAF mutation compared to stage III patients with recurrence. In the fourth paper, histopathological predictors of pathologic complete response (pCR) as well as the association between pre-treatment carcinoembryonic antigen (CEA) levels and pCR in non-smoking and smoking patients receiving preoperative chemo-radiotherapy for rectal cancer were evaluated. Only in non-smokers was a low CEA level significantly associated with pCR, suggesting that the predictive value of CEA for pCR in rectal cancer in smokers can be limited. In sum, this research has investigated a new method for CRC detection and further evaluated the clinical use of prognostic and predictive markers in CRC.
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Matereke, Lavious Tapiwa. "Analysis of predictive power of binding affinity of PBM-derived sequences". Thesis, Rhodes University, 2015. http://hdl.handle.net/10962/d1018666.
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A transcription factor (TF) is a protein that binds to specific DNA sequences as part of the initiation stage of transcription. Various methods of finding these transcription factor binding sites (TFBS) have been developed. In vivo technologies analyze DNA binding regions known to have bound to a TF in a living cell. Most widely used in vivo methods at the moment are chromatin immunoprecipitation followed by deep sequencing (ChIP-seq) and DNase I hypersensitive sites sequencing. In vitro methods derive TFBS based on experiments with TFs and DNA usually in artificial settings or computationally. An example is the Protein Binding Microarray which uses artificially constructed DNA sequences to determine the short sequences that are most likely to bind to a TF. The major drawback of this approach is that binding of TFs in vivo is also dependent on other factors such as chromatin accessibility and the presence of cofactors. Therefore TFBS derived from the PBM technique might not resemble the true DNA binding sequences. In this work, we use PBM data from the UniPROBE motif database, ChIP-seq data and DNase I hypersensitive sites data. Using the Spearman’s rank correlation and area under receiver operating characteristic curve, we compare the enrichment scores which the PBM approach assigns to its identified sequences and the frequency of these sequences in likely binding regions and the human genome as a whole. We also use central motif enrichment analysis (CentriMo) to compare the enrichment of UniPROBE motifs with in vivo derived motifs (from the JASPAR CORE database) in their respective TF ChIP-seq peak region. CentriMo is applied to 14 TF ChIP-seq peak regions from different cell lines. We aim to establish if there is a relationship between the occurrences of UniPROBE 8-mer patterns in likely binding regions and their enrichment score and how well the in vitro derived motifs match in vivo binding specificity. We did not come out with a particular trend showing failure of the PBM approach to predict in vivo binding specificity. Our results show Ets1, Hnf4a and Tcf3 show prediction failure by the PBM technique in terms of our Spearman’s rank correlation for ChIP-seq data and central motif enrichment analysis. However, the PBM technique also matched the in vivo binding specificities of FoxA2, Pou2f2 and Mafk. Failure of the PBM approach was found to be a result of variability in the TF’s binding specificity, the presence of cofactors, narrow binding specificity and the presence ubiquitous binding patterns.
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Sookthai, Disorn. "Risk and Predictive Factors for Liver Cancer : Analysis of Data from a Cohort Study". Thesis, Linköpings universitet, Statistik, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-75038.
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The association between the risk of liver cancer and blood chemistry was investigated in a cohort study with 95,150 men and women from two counties in Sweden. In 1963-65, blood tests and physical measurements were undertaken. All individuals were then followed up until 2007, and a total of 312 were diagnosed with liver cancer. Using survival analysis and logistic regression, significant risk factors were identified. Stepwise Cox proportional hazards regression applied to a main effect model revealed that Glutamic Pyruvate Transaminase (GPT) and Thymol Turbidity (TYM) were the most significant risk factors (p<0.0001), followed by Protein-Bound Hexoses (HEX) (p=0.002), sex (p=0.02), and Serum Iron (p= 0.03). Increasing the level of GPT expressed in U/L from normal (<21) to slightly elevated (21, 31) or substantially elevated (>31) raised the hazard of experiencing liver cancer by a factor of 1.45 and 4.09, respectively. In addition, GPT was found to be the most significant risk factor in almost all age groups among both men and women. However, there was no evidence that elevated GPT levels within the normal range (<21), influenced the risk of liver cancer. Additional subgroup analyses revealed that TYM was highly significant within the group with normal GPT, and a high level of HEX (≥134 mg/dl) increased the hazard 1.55 times in comparison with the lowest HEX group (<115 mg/dl). BMI was significant only in the male subgroup (p<0.01) and, in the obesity group, the hazard of experiencing liver cancer was 1.99 times higher than in the normal BMI group. A significant three-way interaction between GPT, BMI and gender was present (p=0.05) with a robust significant two-way interaction between GPT and BMI (p<0.01) in the male subgroup.
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Lluís, Ganella Carla 1984. "Genetic factors associated with coronary heart disease and analysis of their predictive capacity". Doctoral thesis, Universitat Pompeu Fabra, 2012. http://hdl.handle.net/10803/84185.
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The main expansion of the discovery of genetic variants associated with complex diseases has occurred during the last decade. This expansion has been accompanied, and in some sense motivated, by the desire to use this information to improve the predictive capacity of many diseases with an unidentified familial component, including coronary heart disease (CHD), with the aim of translating this genetic knowledge into clinical practice. This doctoral thesis is structured in two lines of investigation that address distinct aspects of this issue, first to evaluate the possible role of genetic variation in a candidate gene in modulating CHD risk, and second to evaluate whether genetic information can be used to improve risk assessment tools used in clinical practice.
In the first research line (described in Part I), we investigate the contribution of genetic variation in one of the most widely-studied genes in cardiovascular genetics, ESR1, which encodes the Oestrogen receptor α protein. We provide a solid meta-analysis of evidence regarding the most widely-studied variant in this gene and we further explore the role of a broad range of common and uncommon variants in this gene in CHD risk. Using these approaches, we find no evidence of association between the genetic variants studied and CHD risk. However, although we can confidently accept that common genetic polymorphisms are not associated with cardiovascular disease, we cannot discard the possibility that other types of variation in this gene (for instance epigenetic variation) could modify susceptibility to cardiovascular disease, or that other elements of this pathway are associated with an increased risk of CHD. In this research I have provided a reliable answer to this long running unanswered question in cardiovascular genetics, allowing research to re-focus on other elements of this system or other pathways.
In the second line, we explored the possible utility of genetic information obtained from genome-wide association studies (GWAS) in prediction of 10-year risk of CHD events by adding this information to cardiovascular risk functions. We have followed the recommendations proposed by the American Heart Association for evaluating the utility of novel biomarkers in clinical practice, and have demonstrated that although the magnitudes of the effects of these genetic variants on CHD risk are modest, there is a tendency towards improvement in the capacity of the risk functions to predict future CHD events. The translation of genetic information into clinical practice was one of the main motivations for the investment in genome-wide association studies, and my research represents one of the first efforts to explore this possibility.L’expansió principal pel que fa al descobriment de variants genètiques associades amb malalties complexes s’ha dut a terme durant la última dècada. Aquesta expansió ha estat acompanyada, i d’alguna forma motivada, pel desig d’usar aquesta informació per millorar la capacitat de predicció d’aquelles malalties on hi és present un cert component familiar però en les que no es coneixien les variants que conferien un major risc de patir la malaltia, entre elles la cardiopatia isquèmica (CI). La present tesis doctoral està estructurada en dues línies d’investigació que avaluen el possible rol d’un gen candidat en la susceptibilitat de la CI i també avalua la millora en la capacitat de predicció d’un esdeveniment coronari de les eines usades habitualment en la pràctica clínica mitjançant la inclusió d’informació genètica. Més concretament, la primera línea d’investigació es centra en la contribució de la variació genètica en un dels gens més estudiats en relació amb CI: el gen que codifica pel receptor d’estrogens alfa (ESR1). En aquesta línea hem proveït un sòlid meta-anàlisis entre la variant més àmpliament estudiada d’aquest gen i risc coronari i també hem explorat el paper de la majoria de les variants comunes descrites en aquest gen i risc de CI. Mitjançant cap dels anàlisis hem trobat evidència d’associació entre les variants genètiques en aquest gen i el risc de CI. No obstant això, i encara que podem acceptar que les variants genètiques comunes d’aquest gen no estan associades amb esdeveniments coronaris, no podem descartar que altres tipus de variació en aquest gen (com per exemple variació epigenètica) pugui estar modificant la susceptibilitat a patir un esdeveniment coronari, ni tampoc que altres elements de la mateixa cadena de senyalització estiguin associats amb la malaltia. En la segona línea d’investigació, hem explorat el possible paper de les variants genètiques, obtingudes mitjançant estudis d’associació global del genoma (GWAS), en la millora de la capacitat de predicció a 10 anys dels esdeveniments coronaris, mitjançant la seva addició en les funcions de risc cardiovascular clàssiques. Hem seguit les recomanacions proposades per la American Heart Association per l’avaluació en la pràctica clínica de nous biomarcadors, i hem demostrat que, tot i que la magnitud de l’associació d’aquestes variants és modesta, hi ha una tendència cap a la millora de la capacitat de predicció de les funcions de risc.
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Dillard, Deena M. "Predictive factors of brachial plexus neuropathy in wrestling athletes a prospective longitudinal study /". Morgantown, W. Va. : [West Virginia University Libraries], 2006. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=4576.
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Thesis (M.S.)--West Virginia University, 2006.Title from document title page. Document formatted into pages; contains viii, 115 p. : ill. (some col.). Includes abstract. Includes bibliographical references.
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Jerhammar, Fredrik. "On Predictive Factors of Treatment Response in Head and Neck Squamous Cell Carcinoma". Licentiate thesis, Oto-Rhiono-Laryngology and Head & Neck Surgery, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-17781.
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Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer and yearly include 500 000 new cases worldwide. The outcomes for these patients have not been significantly improved over the last decades and the five year survival is still around 50 %. Establishing predictive markers of treatment response will have great impact on the clinical management of this disease.
The aim of this thesis was to elucidate markers of intrinsic response to radiotherapy and cisplatin. Combining expression patterns of 14 proteins and identifying mutations in the p53 gene, we were able to incorporate both protein and genetic changes to create a predictive model termed Number of Negative Points (NNP). We used the NNP model to statistically calculate the combination of factors that had the best correlation to intrinsic radiosensitivity (IR). We established that a panel of three markers, epidermal growth factor receptor (EGFR), survivin and splice site/missence mutations of p53, had the best correlation to IR (R=0.990, p<0.0001).
We also conducted gene expression analysis to investigate what genes and gene ontologies that are different between cell lines with varying IR. Furthermore, we wanted to identify key regulator genes with central positions of molecular networks, which were generated from the transcripts included in the deregulated gene ontologies. A transcriptional profile of 28 key regulator genes was generated. Immunoblot analysis supported deregulation at the protein level of three markers implicated from the transcriptional profile. We propose that these proteins, notch1, thrombospondin 1, and pai‐1 are predictive markers of IR.
Finally, on a subset of cell lines with sensitivity or resistance to cisplatin, we performed gene expression analysis. Markers of intrinsic cisplatin sensitivity (ICS) such as gene ontologies and key regulators of molecular networks were proposed and five genes, APOE, CTNNB1, MMP7, MMP13, and THBS1 were selected for further analysis. Quantitative polymerase chain reaction (qPCR) analysis of these genes in 25 cell lines established that MMP7 (p=0.0013) and MMP13 (p=0.058) are possible predictive markers of ICS.
The markers of IR and ICS presented here could, if confirmed in a clinical setting, guide clinicians in the choice of treatment and thus give a more individualized and effective therapy for patients with HNSCC.
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Huyer, Gregory. "Transitions of Care for People with Dementia: Predictive Factors and Health Workforce Implications". Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/37330.
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As the population ages, policymakers struggle to cope with the increasing demands for home care and institutional long-term care. This thesis project focuses on factors associated with the transition from home to institutional care for people with dementia. Using health administrative data at a population level, we construct a multivariable model that estimates the time between home care initiation after dementia diagnosis and placement in a long-term care home. From the model, we identify protective factors that allow people with dementia to remain at home for longer, with a particular emphasis on the health workforce and the contribution of formal and informal caregivers to delaying the transition from home to institutional care. Together, these results inform policymakers in capacity planning and in determining where investments should be targeted to maintain people with dementia at home, along with the associated health workforce implications.
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Wejde, Gisela. "Posterior capsule opacification and postoperative endophthalmitis following cataract surgery : predictive and protective factors /". Stockholm : Karolinska institutet, 2005. http://diss.kib.ki.se/2005/91-7140-291-8/.
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