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Dreilich, Martin. "Predictive Factors in Esophageal Carcinoma". Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6831.
Pełny tekst źródłaTibau, Martorell Ariadna. "marcadors biològics predictius de resposta a la quimioteràpia primària (neoadjuvant) amb antraciclines i taxans". Doctoral thesis, Universitat Autònoma de Barcelona, 2016. http://hdl.handle.net/10803/399842.
Pełny tekst źródłaPredicting response to chemotherapy is a central challenge in treating patients with breast cancer. Anthracycline–taxane-based chemotherapy produces a modest improvement in survival for women with early-stage breast cancer. However, these drugs are associated with serious side-effects and careful selection is needed to ensure that they are given only to patients who may benefit from them. To date, no specific biomarkers have been identified to predict tumor response to anthracycline-taxane-based chemotherapy. Human epidermal growth factor receptor 2 (HER2), topoisomerase II alpha (TOP2A) genes and chromosome 17 centromere enumeration probe (CEP17) duplication have all been proposed as predictive biomarkers of anthracycline treatment, whereas low expression of the microtubule-associated protein Tau and classes I to IV β-tubulin isotypes has been linked to better response to taxane chemotherapy. However, reports are conflicting, and none of these tumor markers can yet be considered a clinically reliable predictor of response to anthracycline–taxane-based chemotherapy. We studied the predictive and prognostic value of TOP2A gene alterations, HER2 gene amplification, CEP17 duplication and Tau protein expression, as well as classes I to IV β-tubulin isotypes expression in 140 patients with operable or locally advanced breast cancer receiving anthracycline-taxane-based neoadjuvant chemotherapy. The results of this thesis show that: CEP17 duplication predicts pathologic complete response to primary anthracycline-based chemotherapy, and low Tau protein expression is associated with response to neoadjuvant chemotherapy and taxane benefit. Patients with high Tau expression have a better prognosis.
Hemdan, Tammer. "Prognostic and Predictive Factors in Bladder Cancer". Doctoral thesis, Uppsala universitet, Urologkirurgi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-282607.
Pełny tekst źródłaDerwinger, Kristoffer. "Prognostic and predictive factors in colorectal cancer /". Göteborg : Dept. of Surgery, Sahlgrenska University Hospital/Östra, 2009. http://hdl.handle.net/2077/19365.
Pełny tekst źródłaRobinson, Teresa Michelle. "Predictive Factors of Compassion Fatigue Among Firefighters". ScholarWorks, 2016. https://scholarworks.waldenu.edu/dissertations/2332.
Pełny tekst źródłaVanichbuncha, Tita. "Risk Factors and Predictive Modeling for Aortic Aneurysm". Thesis, Linköpings universitet, Statistik, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-80391.
Pełny tekst źródłaHouston, Kelly Charlene. "Maternal prenatal attachment : the role of predictive factors". Thesis, University of Sheffield, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.421025.
Pełny tekst źródłaHupperets, Pierre Stefanus Gerardus Johannes. "Prognostic and predictive factors in primary breast cancer". Maastricht : Maastricht : Universitaire Pers Maastricht ; University Library, Maastricht University [Host], 1995. http://arno.unimaas.nl/show.cgi?fid=8354.
Pełny tekst źródłaEnthoven, Paul. "Back pain : long-term course and predictive factors /". Linköping : Linköpings universitet, 2005. http://www.bibl.liu.se/liupubl/disp/disp2005/med881s.pdf.
Pełny tekst źródłaAdlard, Julian Weldon. "Colorectal cancer : predictive factors for response to chemotherapy". Thesis, University of Leeds, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.415610.
Pełny tekst źródłaSubramanyam, Rajeev. "Factors Predictive of Adverse Postoperative Events Following Tonsillectomy". University of Cincinnati / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1384869860.
Pełny tekst źródłaGilchrist, Randy A. "Factors Predictive of Commitment to Invest in Marriage". DigitalCommons@USU, 1999. https://digitalcommons.usu.edu/etd/2720.
Pełny tekst źródłaZoli, Matteo <1983>. "Predictive Factors of Biological Behaviour in Pituitary Adenoma". Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2019. http://amsdottorato.unibo.it/8761/1/Zoli_Matteo_Tesi.pdf.
Pełny tekst źródłaCole, Elaine. "Characterising factors predictive of infection in severely injured patients". Thesis, Queen Mary, University of London, 2015. http://qmro.qmul.ac.uk/xmlui/handle/123456789/7975.
Pełny tekst źródłaSheard, Mary Kathryn. "A study of possible predictive factors in beginning reading". Thesis, Sheffield Hallam University, 1985. http://shura.shu.ac.uk/20355/.
Pełny tekst źródłaTorres, Palma William Ignacio, i Galaz Mirta Margarita Flores. "Predictive factors of subject well-being in older people". Pontificia Universidad Católica del Perú, 2017. http://repositorio.pucp.edu.pe/index/handle/123456789/123824.
Pełny tekst źródłaEl presente estudio evaluó el efecto de las variables satisfacción con la vida, autopercepción de salud, apoyo social y estilos de enfrentamiento sobre el bienestar subjetivo. Se contó con una muestra de 122 adultos mayores mexicanos del Estado de Yucatán, en la ciudad de Mérida con un rango de edad de 60 a 93 años. Los resultados en mujeres muestran que los estilos de enfrentamiento son predictores del bienestar subjetivo en los afectos negativos. En cuanto a la dimensión cognitiva del bienestar subjetivo, la autopercepción de salud, los estilos de enfrentamiento y la satisfacción con la vida fueron predictores adecuados. En hombres, los resultados demuestran que la dimensión cognitiva del bienestar subjetivo fue predicha a partir de la satisfacción con la vida y los estilos de enfrentamiento. Los hallazgos muestran la importancia del profundizar y promover variables psicosociales en los adultos mayores.
Cette étude a évalué l’effet de la satisfaction de la vie, de l’auto-perception de la santé, du soutien social et des styles d’adaptation sur les variables de bien-être subjectif. Nous avons étudié le niveau de bien-être subjectif d’un échantillon de 122 Mexicains âgés de l’État du Yucatan, dans la ville de Mérida, âgés de 60 à 93 ans. Les résultats chez les femmes montrent que les styles d’adaptation sont des facteurs prédictifs du bien-être subjectif des affects négatifs, en termes de la dimension cognitive du bien-être subjectif, l’auto-perception de la santé, les styles de confrontation et de satisfaction avec la vie étaient des prédicteurs adéquats, tandis que chez les hommes, les résultats montrent que la dimension cognitive du bien-être subjectif est prévu de satisfaction de la vie et les styles d’adaptation. Les résultats montrent l’importance d’approfondir et de promouvoir les variables psychosociales chez les personnes âgées.
Este estudo avaliou o efeito de variáveis, satisfação com a vida, autopercepção de saúde, apoio social e estilos de coping no bem-estar subjetivo. o nível de bem-estar subjetivo foi estudado no estado de uma amostra de adultos mexicanos mais antiga do Yucatan em Merida (n = 122) com uma faixa etária de 60-93 anos. Os resultados em mulheres mais antiga mostram que os estilos de enfrentamento são preditores de bem-estar subjetivo em efeito negativo em termos da dimensão cognitiva do bem-estar de saúde subjetiva auto-avaliação, estilos e satisfação com a vida de enfrentamento foram preditores adequados em homens mais antiga resultados mostram que a dimensão cognitiva do bem-estar subjetivo está previsto a partir de satisfação com a vida e estilos de enfrentamento.
Moskowitz, Chaya S. "Quantifying and comparing the predictive accuracy of prognostic factors /". Thesis, Connect to this title online; UW restricted, 2002. http://hdl.handle.net/1773/9610.
Pełny tekst źródłaJordan, Shannon. "Predictive Factors of Drug Court Completion for Female Participants". ScholarWorks, 2019. https://scholarworks.waldenu.edu/dissertations/7811.
Pełny tekst źródłaWood, Brian. "A prospective multidisciplinary study of falls in Parkinson's disease". Thesis, University of Aberdeen, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.288276.
Pełny tekst źródłaTan, Sanzhi, i 谭三智. "Bronchopulmonary dysplasia in critically ill infants : incidence and predictive factors". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/206959.
Pełny tekst źródłapublished_or_final_version
Public Health
Master
Master of Public Health
Morland, T. "The predictive factors of subjective recovery in first-episode psychosis". Thesis, University College London (University of London), 2007. http://discovery.ucl.ac.uk/1444858/.
Pełny tekst źródłaLefumat, Hannah. "Interlimb transfer of sensorimotor adaptation : predictive factors and underlying processes". Thesis, Aix-Marseille, 2016. http://www.theses.fr/2016AIXM4014/document.
Pełny tekst źródłaMotor adaptation refers to the capacity of our nervous system to produce accurate movements while the properties of our body and our environment continuously change. Interlimb transfer is a process that directly stems from motor adaptation. It occurs when knowledge gained through training with one arm change the performance of the opposite arm movements. Interlimb transfer of adaptation is an intricate process. Numerous studies have investigated the patterns of transfer and conflicted results have been found. The attempt of my PhD project was to identify which factors and processes favor interlimb transfer of adaptation and thence may explain the discrepancies found in the literature. The first two experiments aimed at investigated whether paradigmatic or idiosyncratic features would influence the performance in interlimb transfer. The third experiment provided some insights on the processes allowing interlimb transfer by using the dual-rate model of adaptation put forth by Smith et al. (2006). Our results show that inter-individual differences may be a key factor to consider when studying interlimb transfer of adaptation. Also, the study of the different sub-processes of adaptation seems helpful to understand how interlimb transfer works and how it can be related to other behaviors such as the expression of motor memory
Stukey, Jennifer Kristin. "Predictive Factors of Organizational Support Communication in Volunteer Mentor Retention". ScholarWorks, 2016. https://scholarworks.waldenu.edu/dissertations/1868.
Pełny tekst źródłaPennells, Lisa. "Assessing predictive ability using individual participant time to event data from multiple prospective studies : application to cardiovascular disease risk prediction". Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609800.
Pełny tekst źródłaCirauqui, Cirauqui Beatriz. "Factores pronósticos y predictivos de respuesta en pacientes con carcinoma escamoso de cabeza y cuello". Doctoral thesis, Universitat Autònoma de Barcelona, 2021. http://hdl.handle.net/10803/672595.
Pełny tekst źródłaIntroducción: Los carcinomas escamosos de cabeza y cuello (CECC) son tumores que se diagnostican frecuentemente en una fase localmente avanzada, hecho que condiciona un modesto pronóstico. A pesar del manejo multidisciplinar, presentan una supervivencia global (SG) menor al 40% a los 5 años, debida a un 50-60 % de recurrencias locales y un 20-30% de metástasis a distancia a los 2 años. Por todo esto, existe una necesidad de detectar biomarcadores que nos ayuden a seleccionar la mejor modalidad terapéutica para cada paciente y a desarrollar nuevas estrategias que reviertan las resistencias a los tratamientos convencionales. Objetivos: Con la hipótesis de que los niveles de expresión de genes implicados en las vías de reparación del ADN y la activación de la vía del transductor de señal y activador de la transcripción 3 (STAT3) pueden jugar un papel pronóstico y predictivo de respuesta a diferentes tratamientos del CECC, evaluamos la correlación de los primeros con la eficacia a la quimiorradioterapia (QRT) con platino y de la segunda con la de la combinación de paclitaxel y cetuximab. Material y métodos: Para evaluar el primer objetivo, determinamos los niveles de expresión de ARNm de los genes BRCA1, RAP80, proteína 1 de unión a p53 (53BP1), mediador del punto de control del daño del ADN 1 (MDC1) y RNF8, todos ellos relacionados con la reparación del ADN, y los correlacionamos con la respuesta y la SG en 72 pacientes con CECC localmente avanzado (CECC-LA) tratados con carboplatino semanal AUC 2 y radioterapia (RT). Para evaluar el segundo objetivo, analizamos retrospectivamente las muestras tumorales disponibles de 52 pacientes de una serie con CECC recurrente/metastásico (CECC R/M) tratados con paclitaxel y cetuximab entre 2008 y 2017, y determinamos los niveles transcripcionales de STAT3, la expresión de STAT3 fosforilado (pSTAT3) y la hipermetilación del promotor del gen de la fosfatasa T de proteína tirosina de tipo receptor (PTPRT). Resultados: En la primera serie, la respuesta completa (RC) a la QRT fue significativamente superior en los pacientes que tenían tumores con niveles bajos de 53BP1 en comparación con aquellos con tumores con niveles elevados, y se acompañaba de una tendencia a una mejor SG. Para un pequeño grupo de pacientes con tumores con baja expresión de 53BP1 y BRCA1 o RAP80 alto, la tasa de RC todavía era superior. En la segunda serie, 58,82% de los tumores presentaron metilación del promotor de PRPRT y ésta se asoció significativamente con una menor tasa de respuesta (TR) a paclitaxel y cetuximab. La sobreexpresión de la proteína pSTAT3 se detectó en el 66,67% de los tumores y también se correlacionó con resistencia al tratamiento, aunque no se obtuvieron diferencias significativas. Conclusiones: En nuestro primer trabajo observamos que la eficacia de la RT en combinación con carboplatino en el tratamiento del CECC-LA se correlaciona con los niveles de expresión de ARNm de 53BP1 y que los niveles de expresión de ARNm de BRCA1 y RAP80 parecen reforzar su valor predictivo. En nuestro segundo trabajo, la activación de la vía STAT3, valorada por la sobrexpresión de pSTAT3 y mediada por la metilación del promotor de PTPRT, predice resistencia a paclitaxel y cetuximab en CECC R/M.
Background: Head and neck squamous cell carcinomas (HNSCC) are tumors that are frequently diagnosed in a locally advanced phase, a fact that determines a bad prognosis. Despite multidisciplinary management, they have a 5-year overall survival (OS) of less than 40%, due to 50-60% local recurrences and 20-30% 2-year distant metastases. For this reason, there is a need to detect biomarkers that help us to select the best therapeutic modality for each patient and develop new strategies to reverse resistance to conventional treatments. Objectives: With the hypothesis that the expression levels of genes involved in DNA repair pathways and the activation of the signal transducer and activator of transcription 3 (STAT3) pathway may play a prognostic and predictive role in response to different HNSCC treatments, we evaluated the correlation of the first ones with the efficacy of chemoradiotherapy (CRT) with platinum and of the second ones with that of the combination of paclitaxel and cetuximab. Material and methods: To evaluate the first endpoint, we determined the mRNA expression levels of the genes BRCA1, RAP80, p53-binding protein 1 (53BP1), mediator of DNA damage checkpoint 1 (MDC1) and RNF8, all of them related to DNA repair and correlated them with response and OS in 72 patients with locally advanced HNSCC (LA-HNSCC) treated with weekly AUC 2 carboplatin and radiotherapy (RT). To evaluate the second endpoint, we retrospectively analyzed the available tumor samples from 52 patients from a series with recurrent / metastatic HNSCC (R / M HNSCC) treated with paclitaxel and cetuximab between 2008 and 2017, and we determined the transcriptional levels of STAT3, the expression of phosphorylated STAT3 (pSTAT3), and the hypermethylation of the receptor-type tyrosine-protein phosphatase T (PTPRT) promoter. Results: In the first series, the complete response (CR) to CRT was significantly higher in patients who had tumors with low levels of 53BP1 compared to those with tumors with elevated levels, and a trend towards better OS. For a small group of patients with tumors with low expression of 53BP1 and high BRCA1 or RAP80 expression, the CR rate was still higher. In the second series, 58.82% of the tumors presented PRPRT promoter methylation and it was significantly associated with a lower response rate to paclitaxel and cetuximab. The overexpression of the pSTAT3 protein was detected in 66.67% of the tumors and was also correlated with resistance to treatment, although no significant differences were reached. Conclusions: In our first work we observe that the efficacy of RT in combination with carboplatin in the treatment of LA-HNSCC is correlated with the levels of expression of 53BP1 mRNA, and that the levels of expression of BRCA1 mRNA and RAP80 seem to reinforce its predictive value. In our second work, the activation of the STAT3 pathway measured by the overexpression of pSTAT3 and mediated by the methylation of the PTPRT promoter predicts resistance to paclitaxel and cetuximab in R / M HNSCC.
Universitat Autònoma de Barcelona. Programa de Doctorat en Medicina
Eppes, Susan Elise. "Washington State Ergonomics Tool: predictive validity in the waste industry". Thesis, Texas A&M University, 2004. http://hdl.handle.net/1969.1/547.
Pełny tekst źródłaGjurich, Gregory D. "A predictive model of surface warfare officer retention : factors affecting turnover". Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 1999. http://handle.dtic.mil/100.2/ADA362176.
Pełny tekst źródłaThesis advisor(s): William K. Krebs, Samuel E. Buttrey. "MArch 1999". Includes bibliographical references (p. 49-50). Also available online.
GONCALVES, MARCELO ESTACIO SILVESTRE. "DO BRAZILIAN INDUSTRIES CONTAIN PREDICTIVE INFORMATION FOR THE FAMA-FRENCH FACTORS?" PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2014. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=24934@1.
Pełny tekst źródłaHow are the brazilian industry returns used by investors? Can the information contained in these returns explain the movements of Brazilian shares? The purpose of this work is to help answer these questions by examining whether the returns and the volatility of SMB and HML factors of Fama-French threefactor model can be predicted by past returns of 16 portfolios formed by companies from the same industry listed on São Paulo Stock Exchange (BM&FBOVESPA) between 1995 and 2012. The analysis reveals that 14 of 16 industries predict the SMB returns one month ahead. Furthermore, the returns of a significant number of industries predict the volatility of SMB and HML factors up to three months ahead of time. Considering the explanatory capability of the Fama-French model for the Brazilian market, the results of this research show that Brazilian industry returns contain valuable information for the SMB and HML factors, demonstrating that investors cannot absorb all the information in a timely manner, resulting in their gradual diffusion throughout the market.
Mancini, Kathryn J. "Mother-Adolescent Dyadic Affective Flexibility across Interactions: Measurement and Predictive Factors". Miami University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=miami1529685938908801.
Pełny tekst źródłaDeighton, Jennifer. "DETERMINING PREDICTIVE FACTORS OF INTENT TO STAY WITHIN THE HOSPITALITY INDUSTRY". Kent State University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=kent1604663882181397.
Pełny tekst źródłaUgwu, Gabriel Ugwuja. "Family Predictive Factors of Rural Malaria Prevalence in Nsukka, Eastern Nigeria". ScholarWorks, 2019. https://scholarworks.waldenu.edu/dissertations/7764.
Pełny tekst źródłaLimthanakom, Natcha. "A FRAMEWORK FOR UNDERSTANDING STYLE ROTATION IN U.S. EQUITY MARKETS". NSUWorks, 2010. http://nsuworks.nova.edu/hsbe_etd/61.
Pełny tekst źródłaMoore, Patricia B. "Analysis of predictive factors for fully mission capable rates of deployed aircraft". Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 1998. http://handle.dtic.mil/100.2/ADA355707.
Pełny tekst źródła"September 1998." Thesis adviso(s):Samuel E. Buttrey. Includes bibliographical references (p. 45-46). Also available online.
Stark, Lisa Gail. "An investigation of potential novel predictive factors for graft-versus-host disease". Thesis, University of Newcastle upon Tyne, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.401301.
Pełny tekst źródłaHo, Maria Ming Chee. "ABC transporters as predictive factors for chemotherapeutic response in acute myeloid leukemia". Thesis, University of British Columbia, 2007. http://hdl.handle.net/2429/30890.
Pełny tekst źródłaMedicine, Faculty of
Biochemistry and Molecular Biology, Department of
Graduate
Chow, Chin-ying, i 周展盈. "Evaluation of white coat hypertension in Chinese children : predictive factors and outcome". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/193755.
Pełny tekst źródłapublished_or_final_version
Public Health
Master
Master of Public Health
Wells, Stephen Geoffrey. "Factors affecting the storage and reproduction of predictive smooth pursuit eye movements". Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.321997.
Pełny tekst źródłaSchreckengost, Renee. "Energy-efficient housing alternatives: a predictive model of factors affecting household perceptions". Diss., Virginia Polytechnic Institute and State University, 1985. http://hdl.handle.net/10919/71258.
Pełny tekst źródłaPh. D.
Culshaw, Mary. "Individuals with Fetal Alcohol Spectrum Disorder: Predictive Factors for Successful Occupational Performance". VCU Scholars Compass, 2015. http://scholarscompass.vcu.edu/etd/4074.
Pełny tekst źródłaRowe, Lynn A. "Predictive Factors of Intensive Care Length of Stay in Liver Transplant Recipients". Diss., The University of Arizona, 2014. http://hdl.handle.net/10150/338685.
Pełny tekst źródłaSalters, Jean E. "Predictive Factors of Student Mathematics Achievement Decline Between Third and Fifth Grade". ScholarWorks, 2019. https://scholarworks.waldenu.edu/dissertations/7072.
Pełny tekst źródłaBennett, Rachel. "Alcohol and drug related offences: Determining predictive factors for reducing re-offending". Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2005. https://ro.ecu.edu.au/theses/1563.
Pełny tekst źródłaWallin, Ulrik. "Cancer of the Colon and Rectum : Prognostic Factors and Early Detection". Doctoral thesis, Uppsala universitet, Kolorektalkirurgi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-159142.
Pełny tekst źródłaMatereke, Lavious Tapiwa. "Analysis of predictive power of binding affinity of PBM-derived sequences". Thesis, Rhodes University, 2015. http://hdl.handle.net/10962/d1018666.
Pełny tekst źródłaSookthai, Disorn. "Risk and Predictive Factors for Liver Cancer : Analysis of Data from a Cohort Study". Thesis, Linköpings universitet, Statistik, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-75038.
Pełny tekst źródłaLluís, Ganella Carla 1984. "Genetic factors associated with coronary heart disease and analysis of their predictive capacity". Doctoral thesis, Universitat Pompeu Fabra, 2012. http://hdl.handle.net/10803/84185.
Pełny tekst źródłaL’expansió principal pel que fa al descobriment de variants genètiques associades amb malalties complexes s’ha dut a terme durant la última dècada. Aquesta expansió ha estat acompanyada, i d’alguna forma motivada, pel desig d’usar aquesta informació per millorar la capacitat de predicció d’aquelles malalties on hi és present un cert component familiar però en les que no es coneixien les variants que conferien un major risc de patir la malaltia, entre elles la cardiopatia isquèmica (CI). La present tesis doctoral està estructurada en dues línies d’investigació que avaluen el possible rol d’un gen candidat en la susceptibilitat de la CI i també avalua la millora en la capacitat de predicció d’un esdeveniment coronari de les eines usades habitualment en la pràctica clínica mitjançant la inclusió d’informació genètica. Més concretament, la primera línea d’investigació es centra en la contribució de la variació genètica en un dels gens més estudiats en relació amb CI: el gen que codifica pel receptor d’estrogens alfa (ESR1). En aquesta línea hem proveït un sòlid meta-anàlisis entre la variant més àmpliament estudiada d’aquest gen i risc coronari i també hem explorat el paper de la majoria de les variants comunes descrites en aquest gen i risc de CI. Mitjançant cap dels anàlisis hem trobat evidència d’associació entre les variants genètiques en aquest gen i el risc de CI. No obstant això, i encara que podem acceptar que les variants genètiques comunes d’aquest gen no estan associades amb esdeveniments coronaris, no podem descartar que altres tipus de variació en aquest gen (com per exemple variació epigenètica) pugui estar modificant la susceptibilitat a patir un esdeveniment coronari, ni tampoc que altres elements de la mateixa cadena de senyalització estiguin associats amb la malaltia. En la segona línea d’investigació, hem explorat el possible paper de les variants genètiques, obtingudes mitjançant estudis d’associació global del genoma (GWAS), en la millora de la capacitat de predicció a 10 anys dels esdeveniments coronaris, mitjançant la seva addició en les funcions de risc cardiovascular clàssiques. Hem seguit les recomanacions proposades per la American Heart Association per l’avaluació en la pràctica clínica de nous biomarcadors, i hem demostrat que, tot i que la magnitud de l’associació d’aquestes variants és modesta, hi ha una tendència cap a la millora de la capacitat de predicció de les funcions de risc.
Dillard, Deena M. "Predictive factors of brachial plexus neuropathy in wrestling athletes a prospective longitudinal study /". Morgantown, W. Va. : [West Virginia University Libraries], 2006. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=4576.
Pełny tekst źródłaTitle from document title page. Document formatted into pages; contains viii, 115 p. : ill. (some col.). Includes abstract. Includes bibliographical references.
Jerhammar, Fredrik. "On Predictive Factors of Treatment Response in Head and Neck Squamous Cell Carcinoma". Licentiate thesis, Oto-Rhiono-Laryngology and Head & Neck Surgery, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-17781.
Pełny tekst źródłaHead and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer and yearly include 500 000 new cases worldwide. The outcomes for these patients have not been significantly improved over the last decades and the five year survival is still around 50 %. Establishing predictive markers of treatment response will have great impact on the clinical management of this disease.
The aim of this thesis was to elucidate markers of intrinsic response to radiotherapy and cisplatin. Combining expression patterns of 14 proteins and identifying mutations in the p53 gene, we were able to incorporate both protein and genetic changes to create a predictive model termed Number of Negative Points (NNP). We used the NNP model to statistically calculate the combination of factors that had the best correlation to intrinsic radiosensitivity (IR). We established that a panel of three markers, epidermal growth factor receptor (EGFR), survivin and splice site/missence mutations of p53, had the best correlation to IR (R=0.990, p<0.0001).
We also conducted gene expression analysis to investigate what genes and gene ontologies that are different between cell lines with varying IR. Furthermore, we wanted to identify key regulator genes with central positions of molecular networks, which were generated from the transcripts included in the deregulated gene ontologies. A transcriptional profile of 28 key regulator genes was generated. Immunoblot analysis supported deregulation at the protein level of three markers implicated from the transcriptional profile. We propose that these proteins, notch1, thrombospondin 1, and pai‐1 are predictive markers of IR.
Finally, on a subset of cell lines with sensitivity or resistance to cisplatin, we performed gene expression analysis. Markers of intrinsic cisplatin sensitivity (ICS) such as gene ontologies and key regulators of molecular networks were proposed and five genes, APOE, CTNNB1, MMP7, MMP13, and THBS1 were selected for further analysis. Quantitative polymerase chain reaction (qPCR) analysis of these genes in 25 cell lines established that MMP7 (p=0.0013) and MMP13 (p=0.058) are possible predictive markers of ICS.
The markers of IR and ICS presented here could, if confirmed in a clinical setting, guide clinicians in the choice of treatment and thus give a more individualized and effective therapy for patients with HNSCC.
Huyer, Gregory. "Transitions of Care for People with Dementia: Predictive Factors and Health Workforce Implications". Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/37330.
Pełny tekst źródłaWejde, Gisela. "Posterior capsule opacification and postoperative endophthalmitis following cataract surgery : predictive and protective factors /". Stockholm : Karolinska institutet, 2005. http://diss.kib.ki.se/2005/91-7140-291-8/.
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