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Artykuły w czasopismach na temat "Porphyrin"

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Stölzel, Ulrich, Thomas Stauch i Ilja Kubisch. "Porphyrien". Der Internist 62, nr 9 (29.06.2021): 937–51. http://dx.doi.org/10.1007/s00108-021-01066-1.

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ZusammenfassungPorphyrien werden durch Enzymdefekte der Hämbiosynthese hervorgerufen und anhand spezifischer biochemischer Muster von Porphyrinen und deren Vorläufern in Urin, Stuhl und Blut diagnostiziert. Das jeweilige Muster der akkumulierten Porphyrine, Vorläufer und Derivate ist verbunden mit der klinischen Ausprägung, die abdominale, neurologische, psychiatrische, endokrine, kardiovaskuläre Symptome, Leberschaden und/oder Lichtempfindlichkeit der Haut umfassen kann. Klinisch werden akute und nichtakute Porphyrien unterschieden. Bei symptomatischen (klinisch aktiven), akuten hepatischen Porphyrien – hierzu gehören akute intermittierende Porphyrie, Porphyria variegata, hereditäre Koproporphyrie und Doss-Porphyrie – kommt es aufgrund einer Regulationsstörung zur Kumulation der Porphyrinvorläufer 5‑Aminolävulinsäure und Porphobilinogen. Bei den nichtakuten Formen – u. a. Porphyria cutanea tarda, erythropoetische und X‑chromosomale Protoporphyrie sowie kongenitale erythropoetische Porphyrie – führen akkumulierte Porphyrine zu Lichtempfindlichkeit (Fotodermatose) und mitunter auch zu schweren Leberschäden. Zur Therapie der Porphyrien stehen sowohl bewährte und sichere als auch innovative Optionen zur Verfügung.
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Hindmarsh, J. Thomas, Linda Oliveras i Donald C. Greenway. "Plasma Porphyrins in the Porphyrias". Clinical Chemistry 45, nr 7 (1.07.1999): 1070–76. http://dx.doi.org/10.1093/clinchem/45.7.1070.

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Abstract Background: As an aid in the diagnosis and management of porphyria we have developed a method to fractionate and quantify plasma porphyrins and have evaluated its use in various porphyrias. Methods: We used HPLC with fluorometric detection to measure plasma concentrations of uroporphyrin I and III, heptacarboxyl III, hexacarboxyl III, pentacarboxyl III, and coproporphyrin I and III. We studied 245 healthy subjects, 32 patients with classical porphyria cutanea tarda (PCT), 12 patients with PCT of renal failure, 13 patients with renal failure, 8 patients with pseudoporphyria of renal failure, 3 patients with acute intermittent porphyria, 5 patients with variegate porphyria, 5 patients with hereditary coproporphyria, and 4 patients with erythropoietic protoporphyria. Results: Between-run CVs were 5.4–13%. The recoveries of porphyrins added to plasma were 71–114% except for protoporphyrin, which could not be reliably measured with this technique. Plasma porphyrin patterns clearly identified PCT, and its clinical sensitivity equaled that of urine porphyrin fractionation. The patterns also allowed differentiation of PCT of renal failure from pseudoporphyria of renal failure. Conclusions: The assay of plasma porphyrins identifies patients with PCT and appears particularly useful for differentiating PCT of renal failure from pseudoporphyria of renal failure.
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Woolf, Jacqueline, Joanne T. Marsden, Timothy Degg, Sharon Whatley, Paul Reed, Nadia Brazil, M. Felicity Stewart i Michael Badminton. "Best practice guidelines on first-line laboratory testing for porphyria". Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 54, nr 2 (19.01.2017): 188–98. http://dx.doi.org/10.1177/0004563216667965.

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The porphyrias are disorders of haem biosynthesis which present with acute neurovisceral attacks or disorders of sun-exposed skin. Acute attacks occur mainly in adults and comprise severe abdominal pain, nausea, vomiting, autonomic disturbance, central nervous system involvement and peripheral motor neuropathy. Cutaneous porphyrias can be acute or chronic presenting at various ages. Timely diagnosis depends on clinical suspicion leading to referral of appropriate samples for screening by reliable biochemical methods. All samples should be protected from light. Investigation for an acute attack: • Porphobilinogen (PBG) quantitation in a random urine sample collected during symptoms. Urine concentration must be assessed by measuring creatinine, and a repeat requested if urine creatinine <2 mmol/L. • Urgent porphobilinogen testing should be available within 24 h of sample receipt at the local laboratory. Urine porphyrin excretion (TUP) should subsequently be measured on this urine. • Urine porphobilinogen should be measured using a validated quantitative ion-exchange resin-based method or LC-MS. • Increased urine porphobilinogen excretion requires confirmatory testing and clinical advice from the National Acute Porphyria Service. • Identification of individual acute porphyrias requires analysis of urine, plasma and faecal porphyrins. Investigation for cutaneous porphyria: • An EDTA blood sample for plasma porphyrin fluorescence emission spectroscopy and random urine sample for TUP. • Whole blood for porphyrin analysis is essential to identify protoporphyria. • Faeces need only be collected, if first-line tests are positive or if clinical symptoms persist. Investigation for latent porphyria or family history: • Contact a specialist porphyria laboratory for advice. Clinical, family details are usually required.
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Puzikova, А. I., Е. А. Litvin, D. А. Kildyushkin i А. Е. Druy. "Application of high-performance liquid chromatography in porphyrias diagnostics". Pediatric Hematology/Oncology and Immunopathology 20, nr 3 (8.10.2021): 140–44. http://dx.doi.org/10.24287/1726-1708-2021-20-3-140-144.

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Porphyrias are distinguished by the stage of heme synthesis at which a failure occurs, leading to the accumulation of intermediate products – porphyrins. Due to the low specificity of clinical manifestations of porphyria and the latent course of the disease, their timely diagnosis is difficult. This article substantiates the effectiveness of high-performance liquid chromatography method in the determination of porphyrins. The method is suitable for porphyrin determination in urine, blood and feces of patients. Examples of its work are shown.
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Krivosheev, Alexander B., L. Ya Kupriyanova i M. A. Kondratova. "DOUBLE PORPHYRIA: LITERATURE REVIEW AND ANALYSIS OF CLINICAL OBSERVATION". Russian Journal of Skin and Venereal Diseases 21, nr 2 (15.04.2018): 120–24. http://dx.doi.org/10.18821/1560-9588-2018-21-2-120-124.

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A brief review of the literature on the problem of double porphyria and analysis of its own observation is presented. For more than 10 years patient B was observed for more than 10 years with a verified diagnosis of acute intermittent porphyria, which manifested with acute pain abdominal syndrome, neurological disorders in the form of peripheral polyneuropathy and hemiparesis of lower extremities, and hypertension syndrome was also noted. The observed clinical symptoms corresponded to an acute porphyrin crisis in the manifestation and / or relapse of acute intermittent porphyria. The diagnosis was confirmed by a quantitative determination of the excretory profile of porphyrin precursors (δ-aminocaproic acid, porphobilinogen) and porphyrin fractions (uroporphyrin, coproporphyrin). Their concentrations are significantly (especially porphyrin precursors) exceeding the control values, which is the cardinal diagnostic criterion of acute intermittent porphyria. Against the backdrop of persistent clinical and biochemical remission of acute intermittent porphyria, symptoms of photosensitization of the skin (blisters, erosion, pigment spots) on the dorsal surface of the hands began to appear in 4 years. Later, hypertrichosis was formed in the temporo-periorbital region. The constellation type of the excretory profile of porphyrins began to change. Against the backdrop of persistent increased excretion of porphyrin precursors (δ-aminolevulinic acid and porphobilinogen), a progressive increase in the excretion of the fraction of uroporphyrin was observed, which became dominant (up to 58% of the total content of porphyrins). Such a prolonged observation in the dynamics allowed us to state the appearance of a new variant of the porphyrin exchange disturbance, which, taking into account clinical symptoms, corresponded to another form of hepatic porphyria, namely, late cutaneous porphyria. The clinical and biochemical changes in the excretory profile of the parameters of porphyrin metabolism registered in the dynamics of observation may indicate the occurrence of a combined enzymatic defect characteristic of double porphyria. In our case, a manifestation of late cutaneous porphyria was noted against a background of compensated acute intermittent porphyria.
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Carson, R. W., E. J. Dunnigan, T. D. DuBose, D. E. Goeger i K. E. Anderson. "Removal of plasma porphyrins with high-flux hemodialysis in porphyria cutanea tarda associated with end-stage renal disease." Journal of the American Society of Nephrology 2, nr 9 (marzec 1992): 1445–50. http://dx.doi.org/10.1681/asn.v291445.

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Plasma porphyrin levels are markedly increased in patients with porphyria cutanea tarda (PCT) associated with end-stage renal disease. Conventional hemodialysis (CHD) with lower blood flow rates (less than 250 mL/min) and cuprophan or cellulose acetate membranes is ineffective in removing significant amounts of porphyrins in this condition. Changes in plasma porphyrin levels and porphyrin clearances during hemodialysis with higher blood flow rates and more-permeable, high-efficiency cellulose acetate and high-flux polysulfone dialyzers were evaluated in a chronic hemodialysis patient with PCT and markedly elevated plasma porphyrins. The polysulfone membrane achieved significantly better fractional porphyrin removal (P = 0.02) and porphyrin clearances (P less than 0.01) than did the high-efficiency cellulose acetate membrane. After conversion from maintenance CHD with a standard cellulose acetate dialyzer to a 4-wk period of high-flux hemodialysis (HFHD) with a polysulfone dialyzer, predialysis plasma porphyrins fell by 37%. After returning to CHD, plasma porphyrins returned to the higher prestudy levels. These observations suggest that HFHD with more permeable membranes and higher blood flow rates removes porphyrins more effectively than does CHD. HFHD may be a useful adjunct to other measures used in treating dialysis patients with PCT.
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Egemen, Gamze, Mustafa Hayvalı, Zeynel Kılıç, A. Osman Solak i Zafer Üstündağ. "Phosphorus-nitrogen compounds Part 17: The synthesis, spectral and electrochemical investigations of porphyrino-phosphazenes". Journal of Porphyrins and Phthalocyanines 14, nr 03 (marzec 2010): 227–34. http://dx.doi.org/10.1142/s1088424610001945.

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The reactions of unsymmetrical porphyrins (1 and 2) with Ni(OAc)2·4H2O in boiling DMF produce porphyrin complexes (3 and 4). From the reactions of free porphyrin ligands 1 and 2 with hexachlorocyclotriphosphazatriene, N3P3Cl6 , the new free porphyrino-phosphazene derivatives (5 and 6) are obtained. On the other hand, the reactions of N3P3Cl6 with porphyrin complexes (3 and 4) afford the new porphyrino-phosphazene complexes (7 and 8). In the literature there are a few examples of the porphyrino-phosphazene architectures. The structural investigations of all the compounds have been made by elemental analyses, MS, FTIR, 1H NMR, 31P NMR and UV-visible techniques. The cyclic voltammograms (CVs) are examined in acetonitrile (MeCN) containing 0.1 M tetrabutylammonium-tetrafluoroborate (TBATFB) to investigate the surface attachment properties at the glassy carbon electrode (GCE) and the influence of the presence of metal cations in the porphyrin ring.
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Hindmarsh, J. T. "The porphyrias: recent advances." Clinical Chemistry 32, nr 7 (1.07.1986): 1255–63. http://dx.doi.org/10.1093/clinchem/32.7.1255.

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Abstract Recent research has elucidated several of the hitherto poorly understood steps in heme synthesis. This review describes this metabolic pathway and pinpoints the enzymatic blockages in the various porphyrias. Recent advances in the understanding of the etiology of porphyria cutanea tarda are discussed, as are the abnormalities of porphyrin metabolism seen in chronic renal failure and in lead poisoning. An outline is given of the clinical and biochemical abnormalities seen in the porphyrias. Included is an algorithm to aid in the differential diagnosis of these diseases, and a brief review of the new analytical techniques available for the identification and quantification of porphyrins and their precursors in body fluids.
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Lockwood, W. H., V. Poulos, E. Rossi i D. H. Curnow. "Rapid procedure for fecal porphyrin assay." Clinical Chemistry 31, nr 7 (1.07.1985): 1163–67. http://dx.doi.org/10.1093/clinchem/31.7.1163.

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Abstract Hydrochloric acid extraction of feces in the presence of ether yields an extract suitable for spectrophotometric estimation of total porphyrin and for further separation by "high-performance" liquid chromatography (HPLC) or thin-layer chromatography. A total porphyrin reference interval of less than 200 nmol/g dry weight of feces was established from data on 106 normal subjects on an unrestricted diet. Total fecal porphyrin values in 11 porphyria cutanea tarda patients were considerably higher than given by the widely used Rimington method (respective means, 652 and 239 nmol/g dry weight). Our HPLC method for separation of porphyrin methyl esters on a silica column, with quantification by fluorescence, is described. HPLC separations performed on 23 porphyria cutanea tarda patients gave the following mean proportions of total fecal porphyrins: dicarboxylics 21%, coproporphyrin 9%, isocoproporphyrins 28%, pentacarboxylporphyrin 9%, hexacarboxylporphyrin 11%, heptacarboxylporphyrin 18%, and uroporphyrin 4%.
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Perkins, S. L., i P. M. Johnson. "Loss of porphyrins from solution during analysis: effect of sample pH and matrix on porphyrin quantification in urine by "high-performance" liquid chromatography." Clinical Chemistry 35, nr 7 (1.07.1989): 1508–12. http://dx.doi.org/10.1093/clinchem/35.7.1508.

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Abstract We report the effect of sample matrix and pH on quantification of porphyrins by HPLC with fluorimetric detection. For aqueous solutions of pH less than 2.5, HPLC peak heights of the porphyrins increased with decreasing pH, reaching a plateau at pH less than 1.0. This loss of porphyrins from solutions with pH greater than 1.0 appeared to be due to a combination of microprecipitation and aggregation effects. No such "pH effect" was observed for urine samples supplemented with mixed-porphyrin standards. Addition of trace amounts of albumin to aqueous solutions also decreased these pH-related losses. These findings suggest a porphyrin-protein interaction that prevents microprecipitation and aggregation processes. We conclude that standard solutions of porphyrins for HPLC analysis should be prepared in a urine matrix. If aqueous solutions are used, then the pH must be adjusted to less than 1.0. Urine samples from normal individuals require only adjustment of pH to less than 2 before analysis; however, porphyric urines requiring dilution should be prepared with porphyrin-free urine diluent.
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Rozprawy doktorskie na temat "Porphyrin"

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Luo, Jin-Li. "Porphyrin metabolism in porphyria cutanea tarda". Thesis, Open University, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.315308.

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Guo, Rong. "Porphyrin metabolism in congenital erythropoietic porphyria". Thesis, Open University, 1992. http://oro.open.ac.uk/57392/.

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Meso-hydroxyuroporphyrin I, B-hydroxypropionic acid uroporphyrin I, hydroxyacetic acid uroporphyrin I and peroxyacetic acid uroporphyrin I have been isolated from the urine and plasma of patients with congenital erythropoietic porphyria (CEP) by high-performance liquid chromatography and characterized by liquid secondary ion mass spectrometry and chemical properties. The physico-chemical properties of these compounds have been studied. The hydroxy- and peroxyacetic acid- uroporphyrin I derivatives are the true metabolites of uroporphyrinogen I in vivo and their presence in urine and plasma is a common feature of CEP. The absence of these derivatives in duodenal aspirate and faeces suggests that they are of erythropoietic origin. The mechanism of formation of the hydroxy- and peroxyacetic acid- uroporphyrin I has been investigated. Peroxyacetic acid uroporphyrin I is formed from uroporphyrinogen I in the presence of H202 and iron while the hydroxylated uroporphyrin I derivatives are most probably produced by hydroxyl radicals generated during the formation of peroxyacetic acid uroporphyrin I. Destruction of porphyrins is found in the same reaction and can be prevented bydesferrioxamine, indicating that it is due to hydroxyl radicals. The formation of peroxyacetic acid- and hydroxyuroporphyrin I derivatives are uroporphyrinogen I concentration dependent. These derivatives can only be formed when uroporphyrinogen I is accumulated to a certain concentration (approx. 1-2 ~M) and the formation is then proportional to the uroporphyrinogen I concentration. The peroxylation reaction has been shown to take place only at the acetic acid side-chains of porphyrinogen and not at the propionic acid side-chains. The peroxylation reaction can therefore take place whenever a porphyrinogen with an acetic acid substituent is accumulated. Oral charcoal therapy failed to reduce the porphyrins accumulated in vivo in a patient with CEP. Uroporphyrin I, the major porphyrin accumulating in CEP, was not excreted into bile and interruption of the enterohepatic circulation by binding porphyrins onto charcoal therefore does not benefit CEP. It may, however, be effective in the treatment of hepatic porphyrias in which the accumulated porphyrins are mainly excreted via the gut lumen.
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Lefley, Colin Richard. "Raman spectroscopic studies of porphyrins and porphyrin-protein complexes". Thesis, University of York, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239782.

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Wessendorf, Florian. "Supramolecular fullerene-porphyrin architectures = Supramolekulare Fulleren-Porphyrin-Architekturen". kostenfrei, 2010. http://d-nb.info/1000613593/34.

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Beavington, Richard. "Porphyrin arrays". Thesis, University of Oxford, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.388909.

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Promarak, Vinich. "Porphyrin arrays". Thesis, University of Oxford, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249614.

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Zhang, Wei. "Porphyrin arrays". Thesis, University of Oxford, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.494395.

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Tannert, Sebastian. "Energy and electron transfer in porphyrin-phthalocyanin-porphyrin heterotrimers". Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2013. http://dx.doi.org/10.18452/16850.

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Diese Dissertation leistet einen Beitrag zum Verständnis des Energie- und Elektronentransfers innerhalb von neuartigen supramolekularen Strukturen, die aus einem zentralen Phthalocyanin und zwei axial angekoppelten Porphyrinen bestehen. Zwei solcher Trimere, welche die koordinative Ankopplung von Porphyrinen über ein Silizium-Zentralatom des Phthalocyanins nutzen, wurden im Rahmen der Arbeit zum ersten Mal quantitativ bezüglich auftretender innermolekularer Transferprozesse charakterisiert. Ziel war die Beantwortung der Frage, ob diese Substanzklasse die wunschgemässe Vereinigung von Lichtsammlung und Ladungstrennung ermöglicht. Aus der Kombination der Messdaten, aufgenommen mit einer Vielzahl von Messverfahren, konnten für die beiden untersuchten Trimere in zwei unterschiedlich polaren Lösungsmitteln die Ratenkonstanten der Energie- und Ladungstransferkanäle ermittelt werden. In allen Fällen findet ein effizienter Ladungstransfer von den Porphyrinen zum Phthalocyanin und ein Lochtransfer vom Phthalocyanin zu einem der beiden Porphyrine statt. Dieses Ergebnis bestätigt die Erwartung, dass Lichtsammlung und Ladungstrennung in diesem Molekül vereint auftreten. Zusätzlich zu den beiden oben erwähnten Prozessen findet je nach Lösungmittelpolarität und Struktur der Porphyrine ein dem Energietransfer paralleler Elektronentransfer und ein Ladungsrücktransfer statt. Allerdings zerfällt der ladungsseparierte Zustand zu schnell, was eine praktische Nutzung der untersuchten Verbindungen in Solarzellen noch verhindert und ihre Weiterentwicklung erfordert.
This thesis contributes to the comprehension of energy and electron transfer within novel supra-molecular structures, denominated triads, consisting of a central phthalocyanine axially-coupled to two porphyrins. In the course of this thesis, two of the trimers, were quantitatively characterized regarding their intramolecular transfer processes. Both feature a dative bond between the porphyrins and the phthalocyanine via the central silicium atom of the latter. These investigations aimed at answering whether this class of compounds allows the desired combination of light harvesting and charge separation. The rate constants of both investigated trimers in two solvents with different polarity were determined by the combination of data from a variety of measurement methods. An efficient charge transfer from the porphyrins to the phthalocyanine and a hole transfer from the phthalocyanine to one of the porphyrins occurs in all investigated cases. This result confirms the prospect that light harvesting and charge separation can occur combined in one molecule. Depending on solvent polarity and the structure of the porphyrines, electron transfer parallel to the energy transfer and a charge back transfer takes place in addition to both above-mentioned processes. However, the charge-separated state of the investigated substances decays to fast, still preventing a practical utilization of these compounds in solar cells and necessitating further developments.
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Sek, Sau Yin. "The synthesis of haematoporphyrin derivative III and other novel porphyrins /". Title page, table of contents and abstract only, 1990. http://web4.library.adelaide.edu.au/theses/09PH/09phs4622.pdf.

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Iakushev, Aleksei A. "Amination catalysée par des sels de palladium ou de cuivre pour la synthèse de polymacrocycliques contenant des fragments aza éthers-couronnes, porphyrines et calix[4]arènes". Thesis, Montpellier, 2016. http://www.theses.fr/2016MONTT221/document.

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Les composés polymacrocycliques présentent un grand intérêt grâce à leurs caractéristiques remarquables de coordination. Pour la première fois, l’approche synthétique fonctionnelle aux diverses composés bi- et polycycliques contenant plusieurs fragments d’éthers aza-couronnes, aux cryptands et aux supercryptands à base d’éthers aza-couronnes a été élaborée par Krakowiak et ses collaborateurs au début des années 1990, par l’usage de simples réactions de substitution nucléophile. Actuellement, les composés hétéropolymorphes polymacrocycliques, capables de former des complexes polynucléaires avec différents métaux présentent le plus grand intérêt. Dans la grande majorité des travaux la synthèse de presque toutes les composés polymacrocycliques a été réalisée à l’aide des méthodes non orthodoxes, à l’exception des molécules, composées de plusieurs macrocycles porphyriques (de la diade et de la triade), pour l’obtention desquelles ont été appliquées les réaction de Suzuki, le couplage de Sonogashira et la réaction de Heck. Le laboratoire de synthèse organominérale de la Faculté de chimie de l’Université d’Etat de Moscou a accumulé une riche expérience dans l’utilisation de l’amination pallado-catalysée pour la synthèse de diverses composés macrocycliques et polymacrocycliques, et, actuellement, on étudie activement l’arylation cupro-catalysée des di- et polyamines. À cet égard, l’étude de l’amination cupro-catalysée pour la synthèse de composés polymacrocycliques qui contiennent comme connecteurs des diamines et des polyamines a permis développer des méthodes de catalyse métallique et d’obtenir de nouveaux types de conjugués polytopiques et polymacrocycliques, qui comprennent dans leur composition structurelle des fragments éthers aza-couronnes, porphyrines et calixarènes, étudiés pour leur capacité à détecter des cations des métalliques.Le but de ces recherches est de développer des méthodes catalytiques de synthèse de conjugués polymacrocycliques qui contiennent dans leur composition structurale des fragments éthers aza-couronnes, des porphyrines et des calix[4]arènes et d’étudier leurs capacités à détecter des cations métalliques. Pour atteindre cet objectif, il est nécessaire de résoudre les problèmes suivants: 1) établir la généralité de l’amination catalysée par le Cu(I) des dérivés éthers aza-couronnes et des porphyrines contenant des halogènes et de synthétiser les dérivés aminés; 2) développer des méthodes de la macrocyclisation catalytique pour obtenir des composés macrobicycliques et macrotricycliques qui contiennent dans leur structure des fragments éthers diaza-couronnes, des tétraazamacrocycles ( cyclènes et cyclames) et des calix[4]arènes; 3) modifier les composés macrocycliques et macrobicycliques par des substituants fluorophores, y compris des porphyrines; 4) à l’aide de la spectroscopie UV et de la fluorescence, étudier la liaison cations métalliques-polymacrocycles et identifier les détecteurs potentiels moléculaires fluorescents et colorimétriques
Polymacrocyclic compounds are of great interest due to their unique coordination properties. The first convenient synthetic approach to various polycyclic compounds containing several azacrown-ether moieties, to cryptands and supercryptands, based on azacrown-ethers, has been developed by Krakowiak and coworkers in the beginning of 1990s using simple nucleophilic substitution reactions. At present time heteropolytopic polymacrocyclic compounds, capable of forming polynuclear complexes with various metals, attract the utmost interest. In the majority of publications dealing with the synthesis of polymacrocyclic compounds non-catalytic approaches were applied, except for several porphyrin dyads and triads, which were obtained using Suzuki, Sonogashira and Heck reactions. The laboratory of organoelement compounds of Chemistry Department of Lomonosov Moscow State University has a great experience of the application of Pd-catalyzed amination reactions for the synthesis of polymacrocyclic compounds, nowadays Cu-catalyzed arylation of di- and polyamines is under investigation. Bearing it in mind we have found the research for Cu-catalyzed amination to be important in synthesis of polymacrocyclic compounds containing di- and polyamine linkers; as well as the synthesis of new types of polytopic polymacrocyclic conjugates, bearing azacrown-ether, porphyrin and calixarene moieties, by means of Pd- and Cu-catalyzed reactions; and studying their properties as metal cations detectors.The aim of the research is to develop catalytic synthetic approaches to polymacrocyclic conjugates, bearing azacrown-ether, porphyrin and calix[4]arene moieties, and to study their abilities as detectors for metal cations. For this purpose it is necessary to carry out the following investigations: 1) to study the regularities of Cu(I)-catalyzed amination of halogen derivatives of azacrown-ethers and porphyrins and to synthesize corresponding amino derivatives; 2) to develop the methods for the catalytic macrocyclization aimed at the synthesis of macrobicyclic and macrotricyclic compounds, containing diazacrown-ether, cyclen, cyclam and calix[4]arene moieties; 3) to introduce fluorophoric fragments (including porphyrins) into macrocyclic and macrobicyclic compounds; 4) to investigate metal cations binding by thus synthesized polymacrocycles using UV and fluorescent spectroscopy, and to find possible fluorescent and colorimetric detectors among them
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Książki na temat "Porphyrin"

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R, Moore Michael, i Wintrobe Maxwell Myer 1901-, red. Disorders of porphyrin metabolism. New York: Plenum Medical Book Co., 1987.

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Dobhal, M. P. Porphyrins - Spectral Data of Porphyrin Isomers and Expanded Porphyrins. Redaktorzy V. Gupta, M. D. Lechner i R. Gupta. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-662-47224-8.

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A, Sheldon Roger, red. Metalloporphyrins in catalytic oxidations. New York: M. Dekker, 1994.

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A, Sheldon Roger, red. Metalloporphyrins in catalyticoxidations. New York: M. Dekker, 1994.

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1945-, Kadish Karl M., Smith Kevin M i Guilard Roger, red. The porphyrin handbook. San Diego, Calif: Academic Press, 2003.

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1945-, Kadish Karl M., Smith Kevin M i Guilard Roger, red. The porphyrin handbook. San Diego: Academic Press, 2000.

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Ma, Shengqian, i Gaurav Verma, red. Porphyrin-based Supramolecular Architectures. Cambridge: Royal Society of Chemistry, 2021. http://dx.doi.org/10.1039/9781839164934.

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Kessel, David, red. Methods in Porphyrin Photosensitization. Boston, MA: Springer US, 1985. http://dx.doi.org/10.1007/978-1-4613-2165-1.

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Moore, Michael R., Kenneth E. L. McColl, Claude Rimington i Abraham Goldberg. Disorders of Porphyrin Metabolism. Boston, MA: Springer US, 1987. http://dx.doi.org/10.1007/978-1-4684-1277-2.

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David, Kessel, red. Methods in porphyrin photosensitization. New York: Plenum Press, 1985.

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Części książek na temat "Porphyrin"

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Cleaves, Henderson James. "Porphyrin". W Encyclopedia of Astrobiology, 1326. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-11274-4_1258.

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Cleaves, Henderson James. "Porphyrin". W Encyclopedia of Astrobiology, 2000. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-662-44185-5_1258.

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Cleaves, Henderson James. "Porphyrin". W Encyclopedia of Astrobiology, 1. Berlin, Heidelberg: Springer Berlin Heidelberg, 2022. http://dx.doi.org/10.1007/978-3-642-27833-4_1258-4.

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Cleaves, Henderson James. "Porphyrin". W Encyclopedia of Astrobiology, 1. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-27833-4_1258-3.

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Cleaves, Henderson James. "Porphyrin". W Encyclopedia of Astrobiology, 2445–46. Berlin, Heidelberg: Springer Berlin Heidelberg, 2023. http://dx.doi.org/10.1007/978-3-662-65093-6_1258.

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Dobhal, M. P. "Spectral data of porphyrin derivative C48H33N3S2". W Porphyrins - Spectral Data of Porphyrin Isomers and Expanded Porphyrins, 21–22. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-662-47224-8_10.

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Dobhal, M. P. "Spectral data of porphyrin derivative C50H38N4O2". W Porphyrins - Spectral Data of Porphyrin Isomers and Expanded Porphyrins, 189–90. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-662-47224-8_100.

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Dobhal, M. P. "Spectral data of porphyrin derivative C50H38N4O4". W Porphyrins - Spectral Data of Porphyrin Isomers and Expanded Porphyrins, 191–92. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-662-47224-8_101.

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Dobhal, M. P. "Spectral data of porphyrin derivative C50H38N4O6". W Porphyrins - Spectral Data of Porphyrin Isomers and Expanded Porphyrins, 193–94. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-662-47224-8_102.

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Dobhal, M. P. "Spectral data of porphyrin derivative C50H38N4O6". W Porphyrins - Spectral Data of Porphyrin Isomers and Expanded Porphyrins, 195–96. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-662-47224-8_103.

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Streszczenia konferencji na temat "Porphyrin"

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Ahmed, Md Soif, Chinmoy Biswas, Dipanjan Banerjee, Botta Bhavani, S. Prasanthkumar, Lingamallu Giribabu, Venugopal Rao Soma i Sai Santosh Kumar Raavi. "Ultrafast Photoexcited Molecular Dynamics of Metalated Porphyrin – Napthalimide Based Donor-Acceptor Systems". W CLEO: Applications and Technology. Washington, D.C.: Optica Publishing Group, 2022. http://dx.doi.org/10.1364/cleo_at.2022.jw3b.4.

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Ultrafast excited state molecular relaxation dynamics of two porphyrin-napthalimide molecular systems in donor–acceptor configuration, have been studied using femtosecond transient absorption measurements upon pumping the Soret bands of the porphyrins with 400 nm excitation.
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Neumann, Laurie. "Synthesis of 5,15-A2BC-Type Porphyrins to Modify a Field-Effect Transistor for Detection of Gram-Negative Bacteria". W SurfCoat Korea and Graphene Korea 2021 International Joint Virtual Conferences. Setcor Conferences and Events, 2021. http://dx.doi.org/10.26799/cp-surfcoat-graphene-korea-2021/2.

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Current biological sensing technologies of bacteria are time consuming, labor intensive and thus expensive. Furthermore, their accuracy and reproducibility could be improved. Conventional electrical measurement methods might combine high sensitive sensing systems with biological requirements. A promising approach is the trapping of bacteria on the surface of the gate-electrode of a modified field-effect transistor (FET) using porphyin based self-assembled monolayers (SAMs). 5,15-A2BC-type porphyrins were synthesized originating from a 5,15-diphenylporphyrin with the functionality to connect to a gold surface. The SAM formation on the surface of the gold electrode was proven by well-established analytical methods. In this work a synthesis route is presented for a linker which is attached to a peptide or cysteine group for trapping of Gram-negative bacteria. Fluorescence lifetime imaging microscopy (FLIM) measurements of porphyrin-stained bacteria were performed to verify the linkage ability.
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Kamitani, K., M. Uo, H. Inoue, A. Makishima, T. Suzuki i K. Horie. "Synthesis and Spectroscopy of TPP Derivative-Doped Silica Gels by Sol-Gel Process". W Spectral Hole-Burning and Related Spectroscopies: Science and Applications. Washington, D.C.: Optica Publishing Group, 1994. http://dx.doi.org/10.1364/shbs.1994.wd56.

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We have reported the incorporation of the photochemical hole-burning (PHB) dyes to the silica gels and the observation of spectral holes [1-3]. The porphyrins are well-known PHB dyes. However, in acidic solutions, many porphyrins change their forms into dication which is inactive in PHB [4]. So we have developed two-step sol-gel processes from the hydrolysis of TMOS with NaOH, and successfully incorporated free-base TPPS, a kind of porphyrin, in the silica gels [5].
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Morrow, D. I. J., i R. F. Donnelly. "Novel drug delivery strategies for porphyrins and porphyrin precursors". W 12th World Congress of the International Photodynamic Association, redaktor David H. Kessel. SPIE, 2009. http://dx.doi.org/10.1117/12.822673.

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Eom, Hyo Soon, Cheon Min Kim, Sae Chae Jeoung i Dongho Kim. "Ultrafast Vibrational Relaxation and Ligand Photodissociation/Photoassociation Processes of Nickel(II) Porphyrins". W International Conference on Ultrafast Phenomena. Washington, D.C.: Optica Publishing Group, 1996. http://dx.doi.org/10.1364/up.1996.fe.54.

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The nickel(II) porphyrins have been well suited for an ideal system for investigating electronic decay, axial ligand photodissociation and photoassociation dynamics.1Of great significance in governing photophysics of the four- and six-coordinate nickel(II) complexes is the presence of a low-lying metal excited (dz2,dx2−y2) state having ~250 ps lifetme below porphyrin ring (π,π*) states.1 The (d,d) excited state shows characteristic sharply featured absorption difference spectra, compared to the broader featured more diffuse spectra of the ring (π,π*) and metal⇔ring charge transfer excited states. This favorable properties of the nickel(II) complexes provide a good opportunity for examining the deactivation dynamics in the porphyrin and its interaction with environment that may accompany a transition from an electronic excited state of the macrocycle to an electronic excited state of the metal.
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Помыткина, Татьяна Евгеньевна, Виталия Андреевна Скрипко i Дарья Евгеньевна Фирстова. "CLINICAL CASE OF A PATIENT WITH VARIEGATED PORPHYRIA". W Science. Research. Practice (Наука. Исследования. Практика): сборник статей LXXIV International scientific conference (Санкт-Петербург, Февраль 2024). Crossref, 2024. http://dx.doi.org/10.37539/240216.2024.75.29.002.

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Вариегатная печёночная порфирия - редкое заболевание, разбор клинического случая которого представляет интерес для врача-клинициста. Заболевание проявляется в виде нарушения порфиринового обмена, нейро-висцеральных симптомов и фотодерматоза. Представлен анализ истории болезни пациентки 51 года с диагнозом «Поздняя печёночная порфирия, вариегатная форма». Variegative hepatic porphyria is a rare disease, the analysis of a clinical case of which is of interest to the clinician. The disease manifests itself in the form of impaired porphyrin metabolism, neuro-visceral symptoms and photodermatosis. An analysis of the medical history of a 49-year-old patient with a diagnosis of Late hepatic porphyria, variegated form is presented.
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Zheng, Gang. "Porphyrin Nanophotonics". W Optical Molecular Probes, Imaging and Drug Delivery. Washington, D.C.: OSA, 2013. http://dx.doi.org/10.1364/omp.2013.mw1c.1.

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Harrison, R. J., G. S. Beddard, J. A. Cowan i J. K. M. Sanders. "Detection of the inverted region in photo-induced intramolecular electron transfer". W International Conference on Ultrafast Phenomena. Washington, D.C.: Optica Publishing Group, 1986. http://dx.doi.org/10.1364/up.1986.mc8.

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Photo-induced electron transfer causes the rapid quenching of the excited singlet state of a number of capped porphyrins. The porphyrin donates an electron to an acceptor such as a quinone as shown in the following scheme We have observed a marked decrease in the rate of charge recombination at high -ΔG, in the so called “inverted” region, as predicted by both classical1 and quantum theories2 of electron transfer.
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Sakoda, Kazuaki, i Masayuki Maeda. "Photochemical Hole Burning and Debye-Waller Factor in Polyvinylalcohol doped with Ionic Porphyrins". W Spectral Hole-Burning and Related Spectroscopies: Science and Applications. Washington, D.C.: Optica Publishing Group, 1994. http://dx.doi.org/10.1364/shbs.1994.wd38.

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Photochemical holes can be burned at relatively high temperatures in the Qx band of a free base porphyrin with ionic substituents when the molecule is dispersed in polyvinylalcohol (PVA) [1-2]. This characteristics of the porphyrin-PVA system is due to the facts that the Debye-Waller factor is relatively large [3] and the thermally activated backward reaction is small [4], Figure 1(a) shows one of such porphyrin molecules, TCPP(Na). The large Debye-Waller factor in porphyrin-PVA system is a direct consequence of a high mean phonon frequency. The typical phonon energy of the porphyrin-PVA system, which was determined as the energy deference between the zero-phonon hole and the bottom of the side hole, is as large as 25 cm–1. According to ref. 3, the Debye-Waller factor f(T) of porphyrin-PVA system is well represented by one-phonon approximation.
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Huenerbein, M., Hanns-joerg Sinn, Hans-Hermann Schrenk, W. Maier-Borst i E. A. Friedrich. "Enhancement of porphyrin tumor accumulation by inhibition of porphyrin liver pathway". W International Conference on Photodynamic Therapy and Laser Medicine, redaktor Junheng Li. SPIE, 1993. http://dx.doi.org/10.1117/12.136985.

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Raporty organizacyjne na temat "Porphyrin"

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Michl, J. Pyridinium-Coupled Porphyrin-Based Molecular Grid Membrane. Fort Belvoir, VA: Defense Technical Information Center, lipiec 2001. http://dx.doi.org/10.21236/ada395522.

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Braden, Dale. Synthesis and Characterization of a Porphyrin Dyad. Portland State University Library, styczeń 2000. http://dx.doi.org/10.15760/etd.6852.

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Klunder, G., i R. Silva. An expanded porphyrin approach toward transactinium chelation and the development of porphyrin-coated optical fibers as potential actinide sensors. Office of Scientific and Technical Information (OSTI), grudzień 1994. http://dx.doi.org/10.2172/86912.

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Rebane, Aleksander. Two-Photon Porphyrin Core Dendrimers for Optical Power Limiting. Fort Belvoir, VA: Defense Technical Information Center, wrzesień 2006. http://dx.doi.org/10.21236/ada495180.

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Hays, James Allen. The coordination and atom transfer chemistry of titanium porphyrin complexes. Office of Scientific and Technical Information (OSTI), listopad 1993. http://dx.doi.org/10.2172/10194736.

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Hoefler, Christoph. Preparation of electron donor and acceptor molecules for porphyrin derivatization. Portland State University Library, styczeń 2000. http://dx.doi.org/10.15760/etd.6201.

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Kanan, Matthew W. Local Electric Field Effects on Rhodium-Porphyrin and NHC-Gold Catalysts. Fort Belvoir, VA: Defense Technical Information Center, styczeń 2015. http://dx.doi.org/10.21236/ad1013216.

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Klobukowski, Erik. Bulk gold catalyzed oxidation reactions of amines and isocyanides and iron porphyrin catalyzed N-H and O-H bond insertion/cyclization reactions of diamines and aminoalcohols. Office of Scientific and Technical Information (OSTI), styczeń 2011. http://dx.doi.org/10.2172/1048517.

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Earnshaw, H. C., i B. D. Grant. The Porphyrin maturity parameter as an indicator of oil maturity and the onset of oil generation in the Cretaceous Slater River Formation, Fort Norman area, Northwest Territories. Natural Resources Canada/ESS/Scientific and Technical Publishing Services, 1992. http://dx.doi.org/10.4095/133460.

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Beckett-Brown, C. E., A. M. McDonald i M. B. McClenaghan. Discovering a porphyry deposit using tourmaline: a case study from Yukon. Natural Resources Canada/CMSS/Information Management, 2023. http://dx.doi.org/10.4095/331349.

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As the exploration for porphyry Cu-Au-Mo deposits has become increasingly challenging, the development of more effective techniques directed at detecting buried deposits has become critical. One methodology is to focus on key minerals, one of which is tourmaline, a robust, ubiquitous mineral in most mineralized porphyry systems. Overall, a combination of physical and chemical characteristics including 1) macro-color, 2) morphology, 3) inclusion populations, and 4) trace-element compositions are useful in discriminating between porphyry- versus non-porphyry-derived (or related) tourmaline in surficial sediments (Beckett-Brown 2022). These features are applied to tourmaline obtained from stream sediment samples (n = 22) from 16 streams derived from the unglaciated terrain proximal to the Casino calc-alkaline porphyry Cu-Au-Mo deposit (Yukon Territory, Canada). The obtained tourmaline occurs as two distinct morphologies: 1) individual blocky to prismatic sub- to euhedral grains (Type 1), 2) aggregates of radiating prismatic to acicular sub- to euhedral grains (Type 2). Type 1 grains display trace-element contents that reflect mixed origins including a mineralized porphyry origin as well metamorphic and pegmatitic (background) environments. Type 2 grains almost exclusively exhibit porphyry-derived trace-element chemistries (i.e., high Sr/Pb ~150 avg. and relatively low Zn/Cu ~2.5 avg. values). In Canadian Creek, that directly drains from the Casino deposit, samples closest to the deposit contain &amp;gt;70% porphyry-derived tourmaline, while other streams in the region from unprospective drainage basins contain no porphyry-derived tourmaline. At the most distal sample site in Canadian Creek, ~20 km downstream from Casino, nearly 30% of the recovered tourmaline in the stream sediments is porphyry-related. This method has potential to be a strong indicator of prospectivity and applicable for exploration for porphyry Cu-Au-Mo systems in both unglaciated and glaciated terrains.
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