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Artykuły w czasopismach na temat "PLUMBAGIN ZEYLANICA"
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Purwoko, Mitayani, Harijono Kario Sentono, Bambang Purwanto i Dono Indarto. "Phytochemical evaluation of Plumbago zeylanica roots from Indonesia and assessment of its plumbagin concentration". Folia Medica 64, nr 1 (28.02.2022): 96–102. http://dx.doi.org/10.3897/folmed.64.e58086.
Pełny tekst źródłaStreszczenie:
Introduction:Plumbago zeylanica grows widely in many tropical countries. In Indonesia, this plant, known as Daun Encok, has some beneficial effects on human health. Aim: This exploration study aimed to identify the plumbagin compound in P. zeylanica roots from Indonesia. Materials and methods: Dried roots of P. zeylanica were manually ground and then the powder was macerated using ethanol and chloroform for 24 hours at room temperature. All extracts of P. zeylanica were then analyzed using gas chromatography-mass spectrometry (GC-MS). Plumbagin concentration was measured by comparing the extract with pure plumbagin. Results: GC-MS analysis of ethanol extract and chloroform extract of P. zeylanica roots showed the presence of plumbagin as the highest peak. Plumbagin concentration in ethanol extract was 13%, while in chloroform extract it was 81%. Conclusions: The chloroform extract of P. zeylanica root from Indonesia demonstrates a higher concentration of plumbagin compared to ethanol extract.
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Dubey, Nidhi, Nitin Dubey, Rajendra Mehta i Ajay Kumar Saluja. "Determination of Psoralen and Plumbagin from Its Polyherbal Oil Formulations by an HPTLC Densitometric Method". Journal of AOAC INTERNATIONAL 92, nr 3 (1.05.2009): 779–84. http://dx.doi.org/10.1093/jaoac/92.3.779.
Pełny tekst źródłaStreszczenie:
Abstract Many polyherbal oil formulations in Indian and Chinese traditional systems of medicine used for control of skin diseases contain seeds of Psoralea corylifolia and roots of Plumbago zeylanica L. Psoralen and plumbagin are the reliable markers for Ps. corylifolia and Pl. zeylanica, respectively. However, no attempt is made to standardize the polyherbal oil formulations containing Ps. corylifolia and Pl. zeylanica in terms of their active ingredients or marker compounds. In this paper, a simple, rapid, and sensitive HPTLC method is described for the first time to identify and quantify psoralen and plumbagin from such polyherbal oil formulations. The methanolic extract of oil formulations was used for analysis of markers. Psoralen gives a sharp UV absorbance peak at 302 nm and plumbagin at 275 nm. Good resolution of psoralen (Rf = 0.37) and plumbagin (Rf = 0.77) was attained using tolueneethyl acetate (7.5 + 2.5, v/v) mobile phase. The method was validated in terms of calibration curve, limits of detection and quantification, precision, accuracy, and robustness following a standard protocol. Polyherbal oil formulations were analyzed with reasonable accuracy, and no matrix interference was observed. The method developed can be used for marker-based quality assurance of oil formulations containing Ps. corylifolia and Pl. zeylanica as one active ingredient.
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Ferreira, G. M., i K. S. Laddha. "A METHOD FOR PREPARATION OF DROSERONE FROM PLUMBAGIN". INDIAN DRUGS 50, nr 05 (28.05.2013): 53–56. http://dx.doi.org/10.53879/id.50.05.p0053.
Pełny tekst źródłaStreszczenie:
Droserone (2,5-dihyrdoxy-3-methyl-1,4- naphthoquinone) was prepared from naturally occurring naphthoquinone plumbagin. Plumbagin was isolated from roots of Plumbago zeylanica. Plumbagin was first brominated at C-3 which was subsequently substituted with hydroxy group by a nucleophilic substitution to obtain Droserone. The synthesized compounds were characterized by IR, MS, 1H and 13C NMR spectral data. RP-HPLC was used to ascertain the purity of the obtained compound.
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Ferreira, G. M., i K. S. Laddha. "A METHOD FOR PREPARATION OF DROSERONE FROM PLUMBAGIN". INDIAN DRUGS 50, nr 05 (28.05.2013): 53–56. http://dx.doi.org/10.53879/id.50.05.p0053.
Pełny tekst źródłaStreszczenie:
Droserone (2,5-dihyrdoxy-3-methyl-1,4- naphthoquinone) was prepared from naturally occurring naphthoquinone plumbagin. Plumbagin was isolated from roots of Plumbago zeylanica. Plumbagin was first brominated at C-3 which was subsequently substituted with hydroxy group by a nucleophilic substitution to obtain Droserone. The synthesized compounds were characterized by IR, MS, 1H and 13C NMR spectral data. RP-HPLC was used to ascertain the purity of the obtained compound.
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Adusei, Emmanuel B. A., Reimmel K. Adosraku, James Oppong-Kyekyeku i Cedric D. K. Amengor. "Investigation of Acid-Base Indicator Property of Plumbagin from Plumbago zeylanica Linn". International Journal of Analytical Chemistry 2019 (18.08.2019): 1–13. http://dx.doi.org/10.1155/2019/4061927.
Pełny tekst źródłaStreszczenie:
There has been an increasing interest in the search for colour indicators of natural origin for titrimetric analysis. This is due to some challenges associated with the currently used synthetic ones. This study evaluates and validates the acid-base indicator property of plumbagin isolated from Plumbago zeylanica Linn. Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) was isolated from the roots of Plumbago zeylanica Linn using silica gel chromatography and characterized using spectroscopic methods in comparison with those reported in the literature. Its acid-base indicator property was evaluated alongside phenolphthalein and methyl orange, after it was found to exhibit a sharp change in colour at various pH ranges. The plumbagin indicator was successfully used to assay ibuprofen powder and tablets (400 mg) using the British Pharmacopoeia (2013) method. Data obtained were analyzed statistically by Student’s t-test and one-way ANOVA in GraphPad Prism (version 5.01, 2010). Analysis of the use of the plumbagin indicator in acid-base titrations between strong acids and strong bases and between weak acids and strong bases has been evaluated and validated according to the ICH guidelines. Plumbagin use in ibuprofen powder and tablets has also been verified. Plumbagin has been validated for use as an indicator suitable for different acid-base titrations and the analysis of ibuprofen.
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Phuong, Nguyen Tran Dong, i Tran Thi Xuan Huong. "Effect of natural auxin from portulaca grandiflora hook and Ipomoea batatas (L.) Poir on the formation adventitious roots in vitro of Plumbago zeylanica L." ENGINEERING AND TECHNOLOGY 8, nr 2 (4.06.2020): 30–37. http://dx.doi.org/10.46223/hcmcoujs.tech.en.8.2.344.2018.
Pełny tekst źródłaStreszczenie:
Plumbago zeylanica L. is a traditional herbal that has been reported to treat on skin diseases. Furthermore, some researchers have found plumbagin extracted from roots of this species can prevent cancer cell development. In
current study, stems of Plumbago zeylanica L. were cultured on MS medium with BA 1.0 mg/L and IAA (0.01-0.15 mg/L) or NAA (0.1-0.15 mg/L). After 8-week cultured, stems were transferred to MS medium with extracted from
stems of Portulaca grandiflora Hook (2-10 ml/L) or extracted from stems of Ipomoea batatas (L.) Poir. The results showed that, the appropriate medium for shoot formation was in MS with BA and IAA 0.1 mg/L or NAA 0.1 mg/L.
The adventitious roots in vitro were formatted in MS medium supplied with extracted from stems Portulaca grandiflora Hook or from stems of Ipomoea batatas (L.) Poir 6 ml/L. Simultaneously, after 8-week cultured, the adventitious roots were collected and plumbagin qualitative were analyzed with pure plumbagin of Sigma. As the results, plumbagin presents in adventitious roots cultured.
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Su, Yan, Mao Li, Qi Wang, Xingfeng Xu, Peifang Qin, Haitao Huang, Yuting Zhang, Yali Zhou i Jianguo Yan. "Inhibition of the TLR/NF-κB Signaling Pathway and Improvement of Autophagy Mediates Neuroprotective Effects of Plumbagin in Parkinson’s Disease". Oxidative Medicine and Cellular Longevity 2022 (22.12.2022): 1–14. http://dx.doi.org/10.1155/2022/1837278.
Pełny tekst źródłaStreszczenie:
A naphthoquinone molecule known as plumbagin (PL), which has a wide range of pharmacological properties including antitumor, antioxidation, anti-inflammation, and neuroprotective effects, is extracted from the roots of the medicinal herb Plumbago zeylanica L. Plumbagin has been studied for its potential to treat Parkinson’s disease (PD). However, its effectiveness and mechanism are still unknown. This study intends to evaluate plumbagin’s effectiveness against PD in vitro and in vivo. Plumbagin partially repaired the loss of dopaminergic neurons in the nigral substantia nigra and the resulting behavioural impairment caused by MPTP or MPTP/probenecid in mice. Furthermore, plumbagin treatment significantly inhibited the TLR/NF-κB pathways. It reduced the TNF-α, IL-6, and IL-1β mRNA expression in PD mice induced by MPTP or MPTP/probenecid, which was consistent with the findings in the inflammatory model of BV2 cells induced by MPP+ or LPS. In addition, plumbagin treatment enhanced the microtubule-associated protein 1 light chain 3 beta (LC3) LC3-II/LC3-I levels while decreasing the p-mTOR and p62 protein accumulation in PD mice induced by MPTP or MPTP/probenecid, which was similar to the results obtained from the experiments in SH-SY5Y and PC12 cells induced by MPP+. Consequently, our results support the hypothesis that plumbagin, by promoting autophagy and inhibiting the activation of the TLR/NF-κB signaling pathway, is a promising treatment agent for treating Parkinson’s disease (PD). However, to confirm plumbagin’s anti-PD action more thoroughly, other animal and cell PD models must be used in future studies.
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Aleem, Mohd. "Anti-Inflammatory and Anti-Microbial Potential of Plumbago zeylanica L.: A Review". Journal of Drug Delivery and Therapeutics 10, nr 5-s (15.10.2020): 229–35. http://dx.doi.org/10.22270/jddt.v10i5-s.4445.
Pełny tekst źródłaStreszczenie:
Plumbago zeylanica L. (Pz) is one of the most important medicinal plant belonging to the family Plumbaginaceae. It is a perennial shrub, growing throughout India and most places of Sri Lanka. It contains various bioactive compounds like alkaloids, flavonoids, naphthoquinones, glycoside, saponins, steroids, tri-terpenoids, coumarins, phenolic compounds etc. Of all the chemical constituents, plumbagin is the principal active compound. Plumbagin (5-hydroxy-2-methyl-1, 4-naphthoquinone-C11H8O3) is primarily present in roots in higher amounts with only about 1% in the whole plant. The literature reveals that the root and root bark have a wider claim in traditional medicines against various diseases as a memory enhancer, anti-inflammatory, anti-microbial, wound healing, anti-malarial, anti-infertility, anticancer, blood coagulation, and anti-oxidant activities. The present study aims to evaluate the anti-inflammatory and antimicrobial properties of this plant.
Keyword: Plumbago zeylanica; Sheetraj; Chitrak; Anti-inflammatory; Antimicrobial; Traditional uses
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Rajbhar, Karishma, Jasvinder Kaushal, Himanshu Dawda i Usha Mukundan. "QUANTIFICATION OF LEAF AND ROOT PLUMBAGIN IN PLUMBAGO ZEYLANICA FOLLOWED BY A COMPARATIVE STUDY WITH CALLUS AND COMMERCIAL SOURCE". Journal of Advanced Scientific Research 13, nr 02 (31.03.2022): 202–6. http://dx.doi.org/10.55218/jasr.202213229.
Pełny tekst źródłaStreszczenie:
Plumbago zeylanica shows the presence of many phytochemical constituents of which plumbagin, a type of naphthoquinone, is vital and has major biological effects. Plumbagin is majorly present in the root of the plants, with a minimal concentration in other parts of the plant. However, extracting plumbagin from the roots is destructive harvesting. Thus, micropropagation could be a viable alternative to reduce the collection of plant from wild. Study from micropropagated leaf calli was considered as a steady and sustainable source of phytochemical. P. zeyalnica callus was subcultured in an appropriate medium with plant growth regulators to initiate root cultures. A comparative study was performed to estimate the quantities of plumbagin obtain from the wild plant root part and root created by callus culture differentiation.
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Patel, Hetal D., Ramar Krishnamurthy i Musibau A. Azeez. "Effect of Biofertilizer on Growth, Yield and Bioactive Component of Plumbago zeylanica (Lead Wort)". Journal of Agricultural Science 8, nr 5 (13.04.2016): 141. http://dx.doi.org/10.5539/jas.v8n5p141.
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<p>A comparative study on effect of chemical fertilizer and biofertiliser on Plumbago zeylanica for growth, yield and bioactive component was conducted at Bardoli (district-Surat), India between 2012 and 2013 using Random Block Design method and monthly observation of growth parameters. Application of biofertiliser Azotobacter, Azospirillum, Phosphate solubilizing Bacteria and mixture of Aza + Azo + PSB increased plant height, number of branches, number of leaves, length of root, fresh weight, dry weight and bioactive component (plumbagin). Highest effect on height (91.33±10.13) of plant was obtained with PSB applied biofertiliser whereas the number of branches (14.67±0.47) and number of leaves (25.60±13.17) was obtained with Azospirillum biofertilizer application. The length PSB (33.33±1.32), fresh weight (26.44±1.32) and dry weight of roots (24.66±1.13) was realized with application of mixture of Aza + Azo + PSB. The bioactive component (plumbagin) was high with application of Azospirillum (0.026%w/w) using HPLC. The results of this study suggest that biofertiliser have the potential to increase the growth, yield and bioactive component of Plumbago zeylanica.</p>
Rozprawy doktorskie na temat "PLUMBAGIN ZEYLANICA"
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Nguyen, Anh Tho. "Structure elucidation and biological evaluation of cytotoxic constituents isolated from three Vietnamese medicinal plants :Plumbago Zeylanica, Scrophularia Ningpoensis and Disporopsis Aspera". Doctoral thesis, Universite Libre de Bruxelles, 2005. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210998.
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ROY, ARPITA. "BIOTECHNOLOGICAL APPROACHES FOR THE PRODUCTION OF PLUMBAGIN FROM PLUMBAGO ZEYLANICA". Thesis, 2020. http://dspace.dtu.ac.in:8080/jspui/handle/repository/18075.
Pełny tekst źródłaStreszczenie:
Demand for medicinal plants has drastically enhanced due to the presence of therapeutically
important compounds and is continuously rising in national and international markets. Exploring
elite accession among numerous accessions, collected from different locations is an alternative
approach to satisfy the increase demand of medicinal plants. Biotechnological approaches are
reliable source for production of therapeutically important compound. It also provides long-term
utilization of plants.
Plumbago zeylanica, a pharmaceutically important medicinal plant has been explored in the
present study. In vitro shoot culture was established for five accessions of Plumbago zeylanica.
Four different plant tissue culture media, three different carbon sources and three different nitrogen
sources were tested for five accessions of P. zeylanica to evaluate optimum culture condition based
on growth. The accession which showed maximum shoots number was chosen for further
investigation. Accession-based study of in vitro shoot culture showed that accession number IC
524441 is one of the elite accessions and chosen for further studies.
Adventitious root suspension culture was explored for enhanced production of plumbagin.
Optimization of adventitious root suspension culture showed that highest plumbagin production
was obtained in ½ strength MS liquid media having 3% sucrose with 2 g/L of inoculum density.
Further elicitation with yeast extract (150 mg/L) increases threefold plumbagin production as
compared to control one and highest plumbagin production was 90.96±0.51 µg/mL.
Further cell suspension culture was also explored for enhanced production of plumbagin.
Optimization of cell suspension culture showed that MS medium having 1 mg/L NAA with 3 g/L
inoculum density and 150mg/l yeast extract at pH 5.8 was optimal for plumbagin production.
Maximum plumbagin production was enhanced up to 3.3 times as compared to control one and
maximum amount of plumbagin production was 83.30±0.18 µg/mL.
Biochemical analysis of thirteen different accessions of Plumbago zeylanica were performed
where concentration of therapeutically important compounds such as total plumbagin, total
flavonoids content, total phenol content, total tannin content and antioxidant activity were
evaluated and results showed that IC-524441 is an elite accession. Same thirteen accessions were
assessed for genetic diversity analysis using CBDP and SCoT marker. Genetically diverse
accessions can be utilized by plant breeders for the generation of elite accessions which have high
quantity of pharmaceutically important secondary metabolites.
Further residual plant material of P. zeylanica was used for silver nanoparticles synthesis and its
application in antibacterial and dye degradation were investigated. Biochar was also derived from
residual shoot and root culture and its application in removal of cadmium and chromium were
studied.
Role of plumbagin against different cancer receptor using in silico method was also evaluated. The
ligand plumbagin was docked against three different cancer receptors i.e. COX-2, EGFR and
TACE to evaluate its potential effect on different cancer. In-silico studies showed that plumbagin
is a potential therapeutic agent for treatment of cancer and same can be established through in vivo
studies and clinical trials to confirm its efficiency in patients.
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Hsieh, Yen-Ju, i 謝硯如. "Herbal analysis of plumbagin content in Plumbago zeylanica L. and its pharmacokinetics in rats". Thesis, 2009. http://ndltd.ncl.edu.tw/handle/67603226326872277118.
Pełny tekst źródłaStreszczenie:
博士國立陽明大學
傳統醫藥學研究所
97
Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) is an herbal ingredient which is isolated from the root of Plumbago zeylanica L. In previous reports, there is information on the separations of plumbagin from P. zeylanica L. and its analytical method. Also in recent years, some studies investigated pharmacological functions such as anti-cancer, anti-inflammation and central nervous system effects. However, the absorption, distribution, metabolism, and elimination of plumbagin are still unknown. First of all, a reliable liquid chromatography coupled with tandem mass spectrometric (LC-MS/MS) method was developed to determine the contents of plumbagin from P. zeylanica L. Secondly, an automated blood sampling system for serial blood sampling from conscious and freely moving rats coupled with LC-MS/MS method was used to evaluate the oral bioavailability of plumbagin. Thirdly, microdialysis sampling techniques coupled with high performance liquid chromatography and ultraviolet spectrometry was developed to simultaneously assess the unbound plumbagin in rat blood and bile. Moreover, the roles of P-glycoprotein transport and glucuronidation metabolism on the pharmacokinetics of plumbagin were also estimated by using cyclopsorin A and probenecid to inhibit respective pathways. Finally, the elimination of plumbagin in urine and feces were measured to determine the unabsorbed part and possible metabolites of plumbagin after oral administration. The results indicate that mass fractions of plumbagin in Plumbago zeylanica L. for H2O, 50 % ethanol (v/v) and 95 % ethanol (v/v) were 0.2 ± 0.04, 3.9 ± 0.71 and 13.4 ± 1.30 g/kg, respectively. The oral bioavailability of plumbagin was 38.7 ± 5 %. Unbound plumbagin appeared in blood and bile microdialysate. The AUC of plumbagin in blood and bile were 59.9 ± 7.1 and 31.2 ± 1.8 min･µg/mL, respectively. Furthermore, the bile-to-blood distribution ratio (AUCbile/AUCblood) of plumbagin was 1.7. These results suggest that plumbagin can be excreted in the bile. In combination with P-glycoprotein inhibitor, the concentration of plumbagin in bile declined, but not in blood. This data supports the idea that excretion of plumbagin in bile is regulated by P-glycoprotein. In combination with glucuronidation inhibitor, the concentration of plumbagin in bile increased, but not in blood. The result supports that plumbagin excreted through the glucuronidation pathway. 49.2 % of plumbagin appeared in feces within 84 hours, and 12 % of plumbagin appeared in urine 120 hours after oral administration, approximately. Furthermore, possible metabolites of plumbagin were found in rat urine and they were produced by the metabolism of plumbagin in liver with phase I aliphatic hydroxylation (MW 203) and phase II glucuronidation (MW 363 and 539) in urine, as identified by LC-MS/MS. In conclusion, this study developed a reliable LC-MS/MS to determine the absorption, distribution, metabolism and elimination of plumbagin in the rat. Herbal analysis of Plumbago zeylanica L. and pharmacokinetics of plumbagin will provide some valuable information for future clinical application.
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THAKRAN, NEERU. "ESTIMATION OF PLUMBAGIN BY RP-HPLC & FAME ANALYSIS BY GC-MS OF IMPORTANT MEDICINAL PLANT PLUMBAGO ZEYLANICA". Thesis, 2016. http://dspace.dtu.ac.in:8080/jspui/handle/repository/15047.
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Plumbago zeylanica is an important medicinal plant used in the cure of various diseases. Due to its various therapeutic values, this plant is being researched for high biomass production as well as achievement of maximum yield of bioactive compounds. In the present study, effect of different media and carbon source on in vitro shoot regeneration of five different accessions of Plumbago zeylanica using nodal explants was investigated. Among the three types of carbon sources that were employed in the present study, sucrose proved to be a better choice for multiple shoot regeneration followed by fructose and glucose in five different accessions of P. zeylanica. MS medium provided maximum growth among four different media tested i.e. MS, White, B5 and Nitsch. Quantitative analysis of important bio-active compound plumbagin was performed using standard protocol by reverse phase high performance liquid chromatography of methanolic extract of roots of accession number 524441 which was found a potential accession in a previous study of plant elicitors. Elicitors enhanced plumbagin concentration three times in comparison with the reference. In addition to these three studies, shoots of this plant was also used for fatty acid methyl ester (FAME) profiling. FAME analysis concluded that this plant is rich in C14, C15, C16 and C18 fatty acids. Maximum percentage of fatty acids is found in accession number 421418. Accession number 524441 showed presence of each fatty acids.
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RASTOGI, ANSHIKA. "BIOTIC ELICITORS USED TO ENHANCE PLUMBAGIN PRODUCTION IN PLUMBAGO ZEYLANICA AND ASSESMENT OF ANTIOXIDANT AND ANTIBACTERIAL ACTIVITY". Thesis, 2020. http://dspace.dtu.ac.in:8080/jspui/handle/repository/18363.
Pełny tekst źródłaStreszczenie:
Plumbago zeylanica (chitraka) is the most prominent herbal plant which is used as a medication
to cure skin problems and infections such as ringworm, dermatitis, sores, acne and scabies.
Traditionally all parts of Plumbago zeylanica have been utilized as a medication against many
diseases. In Ayurveda chitraka is described as tumour- negating, appetizer, anti-anorexic and
pain-reliever due to the presence of several important bioactive compounds such as alkaloid,
tannins, phenols and naphthoquinones like plumbagin which is the most active constituent of
this herb. Due to extensive use of this plant as a potent medicinal herb, micropropagation is
necessary for higher biomass and plumbagin production. Since resistance to antibiotic against
several microbes has become a critical issue in the whole world. So, to conquer this difficulty,
identification and discovery new herbal drugs are necessary. In the current study, three elicitors
namely yeast extract, malt extract and chitosan were used to enhance the plumbagin synthesis
in Plumbago zeylanica as well as analysis of its antioxidant and antibacterial activity. Shoot
culture of Plumbago zeylanica was performed in MS media which was supplemented with
200µl BAP and 150mg/l elicitors and then incubated for several weeks. Application of three
biotic elicitors enhance the plumbagin production significantly. Phytochemical analysis of
compound was carried out by UV-visible analysis which exhibited the presence of total phenol
and tannin. DPPH free radical scavenging activity of all accession was performed to check
their antioxidant potential. Cultures were also analysed for their antibacterial potential against
E,coli and S.aureus. Results were expected that application of elicitors in Plumbago zeylanica
shoot culture enhance the plumbagin production as well as other bioactive compounds.
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Huang, Tung-Liang, i 黃棟樑. "Studies of anti-Helicobacter pylori activity of Plumbago zeylanica Linn., a Taiwanese folk medicinal plant". Thesis, 2004. http://ndltd.ncl.edu.tw/handle/39249470664857591359.
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碩士國立中興大學
食品科學系
92
Helicobacter pylori has been verified to be strongly correlated to gastric cancer and peptic ulceration. The most effective and famous treatment for H. pylori is a triple therapy, which combines two antibiotics with either an acid suppressor or a stomach lining protector. However, resistance to some antibiotics became a problem due to the frequently use of antibiotics. In this study, first, ethanol extracts of fifty Taiwanese folk medicinal plants were screened for their anti-H. pylori activity. Five herbs, Plumbago zeylanica Linn. (PZL), Paederia scandens Mer, Anisomeles indica (L.) O. Kuntze, Alpinia speciosa (Wendl.) K. Schum. and Bombax malabaricum DC., showed strong anti-H. pylori activity. Twenty six herbs including Artemisia argvi Levl. et Vant, Bidens bipinnata L., Bletilla formosana (Hayata) Schltr, Chenopodium ambrosioides L., Canarium album (Lour.) Raeuschel, Centella asiatica (L.) Urban., Ehretia acuminata R. Br., Houttuynia cordata Thunb., Litsea cubeba (Lour.) Persoon, Ludwigia octovalvis (Jacq.) Raven., Melastoma candidum D. Don, Polygonum chinense Linn., Psidium guajava L., Phyla nodiflora (Linn.) Greene, Polygonum senticosum (Meissn) Franch. et Sav., Rhus semialata Merr. var. roxburghiana DC, Sonchus arvensis Linn., Sphenomeris chusana (L.) Copel, Sambucus chinensis Lindl., Setaria palmfolia Stapf, Senecio scandens Buch-Ham., Tridax procumbens L. , Vernonia cinerea (L.) Less., Wikstroemia indica (L.) C. A. Mey, Xanthium strumarium Linn., and Zanthoxylum nitidum (Roxb.) DC. showed moderate anti-H. pylori activity. The other nineteen herbs including Areca catechu Linn., Agrimonia pilosa Ledeb., Amaranthus spinosus L., Amaranthus virdis L., Bischofia javanica Blume, Bidens pilosa L. var. minor (Blume) Sherff, Cayratia japonica (Thunb.) Gagnep., Catharanthus roseus (L.) G. Don., Cycas revoluta Thunb., Euphorbia hirta Linn., Flemingia philippinensis Merr. & Rolfe, Gnaphalium adnatum Wall. ex DC., Hibiscus muthtabilis Linn., Milletia reticulata Bentham, Phyllanthus urinaria Linn., Sophora flavescens Ait., Solanum nigrum Linn., Sida rhombifolia Linn., and Viola mandshurica only showed low anti-H. pylori activity. PZL, which showed the strongest anti-H. pylori activity in the primary screening, was selected as study material , and the anti-H. pylori activities of PZL extracts were discussed in this study. PZL is a plant that grows throughout Asia and Africa. The whole plant and its roots have been used as a folk medicine for the treatment of rheumatic pain, dysmenorrhea, carbuncle, coutusion of extremities, ulcers, and killing intestinal parasites in Taiwan. To test the anti-H. pylori activity of PZL, four kinds of extracts were prepared to test on five H. pylori strains. Water and the organic solvents such as ethanol, acetone and ethyl acetate were used for PZL extraction. The ethyl acetate extract showed greatest anti-H. pylori activaty and lowest minimum inhibitory concentrations (MICs) (0.32 mg/mL ~ 1.28 mg/mL). Bactericidal activities were observed on the ethyl acetate, acetone and ethanol extracts studies. The ascending order of minimum bactericidal concentration (MBCs) was ethyl acetate, acetone, and ethanol extracts, and bactericidal activities were appeared to be dose dependent. The bactericidal activity observed on the ethyl acetate extract acted over a wide pH range (pH 2-7). The anti-H. pylori activity wouldn’t be affected by pH, even pretreating the ethyl acetate extract in pH 1-7 buffer for 2 hours wouldn’t affected its anti-H. pylori activity. According to the literatures, the major ingredient, plumbagin, derived from the roots of PLZ was a naphthoquinone compound. In this study, plumbagin also observed to have strong anti-H. pylori activity. A High-performance Liquid Chromatography (HPLC) assay was developed and validated for the quantitative analysis of plumbagin of PZL. The reverse-phase HPLC was performed by using a gradient mobile phase composing water and methanol, and peaks were detected at 254 nm (ultraviolet detection). Standard curves were linearized in the range from 10 to 200 g/mL (regression coefficient r2 = 0.99995). After spiked 50, 100, and 150 g/mL of plumbagin standard solution, the recoveries were between 97.45 % and 99.24 %. Both the intra-day and inter-day precision (RSD) were found less than 1 % coefficient variation at concentrations of 50, 100, and 150 g/mL. The detection and quantitation limits were 210-4 and 610-4 g, respectively. Based on the validation results, the analytical method showed to be a precise, accurate and stable method to quantify plumbagin of PZL.
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Chen, Yi-Chun, i 陳怡君. "Regulation of Proliferation and Cytokine Genes Expression in Human Peripheral Blood Mononuclear Cells by Bioactive Components from Plumbago zeylanica". Thesis, 2003. http://ndltd.ncl.edu.tw/handle/36227376478546430081.
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碩士國立陽明大學
藥理學研究所
91
Action mechanisms of elliptinone (C22H14O6; M.W. 374), xanthyletin (C14H12O3; M.W. 228), xanthoxyletin (C15H14O4; M.W. 258), seselin (C14H12O3; M.W. 228), 5-methoxyseselin (C15H14O4; M.W. 258), and suberosin (C15H16O3; M.W. 244) isolated from Plumbago zeylanica on phytohemagglutinin (PHA) stimulated cell proliferation were studied in primary culture of human peripheral blood mononuclear cells (PBMCs). The results demonstrated that these components suppressed PBMCs proliferation, at about 0 to 24 hr after stimulation with PHA. Cell cycle analysis indicated that elliptinone, xanthyletin, xanthoxyletin, seselin, 5-methoxyseselin, and suberosin arrested the cell cycle progression of activated PBMCs from the G1 transition to the S phase. To further localize the point in the cell cycle at which arrest occurred, a set of key regulatory events leading to the G1/S boundary, including the expression and production of cyclins and cytokines, activation of NF-AT and NF-κB, mobilization of intracellular Ca2+ ([Ca2+]i), and phosphorylation of mitogen-activated protein (MAP) kinases, were examined. These compounds suppressed, in activated PBMCs lymphocytes, the production and mRNA expression of interleukin-2 (IL-2) and interferon-γ (IFN-γ). The levels of Cyclin D3 and Cyclin E proteins in PBMCs stimulated with PHA were reduced by subersoin. Both 5-methoxyseselin and suberosin impaired the production of Cyclin A in activated PBMCs. Results of confocal microscopy analysis indicated that the translocation of the NF-AT and NF-κB in PBMCs induced by PHA were suppressed by 5-methoxyseselin and suberosin. Furthermore, 5-methoxyseselin and suberosin reduced [Ca2+]i in activated PBMCs. The phosphorylation of extracellular-signal regulated kinase (ERK) protein in activated PBMCs stimulated with PHA was attenuated by 5-methoxyseselin and suberosin. Thus, the suppressant effects of 5-methoxyseselin and suberosin on proliferation of PBMCs activated by PHA appeared to be mediated, at least in part, through reduction of [Ca2+]i , ERK kinases activation and early genes expression in PBMCs, especially those of important cyclins, IL-2, and IFN-γ, and arresting cell cycle progression in the cells.
Części książek na temat "PLUMBAGIN ZEYLANICA"
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Dev, Sukh. "Plumbago zeylanica". W Prime Ayurvedic Plant Drugs, 564–70. Cham: Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-22075-3_81.
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Khare, C. P. "Plumbago zeylanica Linn." W Indian Medicinal Plants, 1. New York, NY: Springer New York, 2007. http://dx.doi.org/10.1007/978-0-387-70638-2_1235.
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Akbar, Shahid. "Plumbago zeylanica L. (Plumbaginaceae)". W Handbook of 200 Medicinal Plants, 1475–83. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-16807-0_152.
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Russell, Scott D. "Biphasic pollen tube growth in Plumbago zeylanica". W Biotechnology and Ecology of Pollen, 385–90. New York, NY: Springer New York, 1986. http://dx.doi.org/10.1007/978-1-4613-8622-3_62.
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Bloch, Khalida, Vijay Singh Parihar, Minna Kellomäki i Sougata Ghosh. "Natural Compounds from Plumbago zeylanica as Complementary and Alternative Medicine". W Handbook of Oxidative Stress in Cancer: Therapeutic Aspects, 415–42. Singapore: Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-5422-0_33.
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Bloch, Khalida, Vijay Singh Parihar, Minna Kellomäki i Sougata Ghosh. "Natural Compounds from Plumbago zeylanica as Complementary and Alternative Medicine". W Handbook of Oxidative Stress in Cancer: Therapeutic Aspects, 1–28. Singapore: Springer Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-1247-3_33-1.
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"Chitrak (Plumbago zeylanica)". W Rasayana, 114–15. CRC Press, 2002. http://dx.doi.org/10.1201/b12602-41.
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Tripathi, M. K., G. Tiwari, Sushma Tiwari, Niraj Tripathi, Mohini Sharma, Shashank Bhargav, S. L. Patidar i Sharad Tiwari. "Influence of Plant Growth Regulators on In vitro Morphogenesis in Plumbago Zeylanica Linn." W Research Aspects in Biological Science Vol. 7, 96–123. Book Publisher International (a part of SCIENCEDOMAIN International), 2022. http://dx.doi.org/10.9734/bpi/rabs/v7/3679a.
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