Rozprawy doktorskie na temat „Placental hypoxia”
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Albers, Renee E. "Hypoxia Inducible Factor 1 Alpha (HIF-1a): A Major Regulator of Placental Development". Wright State University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=wright1377277444.
Pełny tekst źródłaVanderlelie, Jessica, i n/a. "Placental Oxidative Stress in Preeclampsia". Griffith University. School of Medical Science, 2006. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20060918.161726.
Pełny tekst źródłaVanderlelie, Jessica. "Placental Oxidative Stress in Preeclampsia". Thesis, Griffith University, 2006. http://hdl.handle.net/10072/365679.
Pełny tekst źródłaThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Medical Science
Full Text
Kulkarni, Kashmira. "HIF-1 alpha: a master regulator of trophoblast differentiation and placental development". Wright State University / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=wright1247186848.
Pełny tekst źródłaHung, T. H. "In vitro hypoxia-reoxygenation as a model for placental oxidative stress in preeclampsia". Thesis, University of Cambridge, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.604788.
Pełny tekst źródłaFreitas-Andrade, Moises. "Mechanisms of Hypoxia-Induced Neurovascular Remodeling in PlGF Knockout Mice". Thesis, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/20566.
Pełny tekst źródłaAnelli, G. M. "EX VIVO AND IN VITRO MODELS TO STUDY THE EFFECTS OF HYPOXIA AND INFLAMMATION ON HUMAN PLACENTAL MITOCHONDRIA". Doctoral thesis, Università degli Studi di Milano, 2015. http://hdl.handle.net/2434/263801.
Pełny tekst źródłaDoran, Diane Michelle. "HYPOXIC INDUCTION AND THE ROLE OF HIFS IN THE ACTIVATION OF LUCIFERASE CONSTITUTIVE REPORTERS IN PLACENTAL STEM CELLS". Wright State University / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=wright1190149635.
Pełny tekst źródłaMaeda, Mariane de Fátima Yukie. "Cardiotocografia computadorizada e dopplervelocimetria em gestações com insuficiência placentária: associação com a lesão miocárdica fetal e a acidemia no nascimento". Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/5/5139/tde-17012014-121048/.
Pełny tekst źródłaObjective: To evaluate the reliability of fetal heart rate parameters analyzed by computerized cardiotocography (cCTG) and fetal Doppler to predict myocardial damage and acidemia at birth in pregnancies complicated by placental insufficiency. Methods: Forty nine patients with placental insufficiency (abnormal umbilical artery Doppler - pulsatility index [PI] > p95) diagnosed between 26-34 weeks of gestation were prospectively studied. All patients were submitted to Dopplervelocimetry of umbilical artery, middle cerebral artery and ductus venosus and to the cCTG (Sonicaid Fetal Care, version 2.2; 30 minutes of duration). We analyzed the last fetal assessment 48h before delivery and prior to steroid therapy.Umbilical cord blood samples were collected at birth to detect acidemia (pH < 7.20) and myocardial damage (cTnT >= 0.09 ng/ml). The results of cTnT were available in 38 cases and in 46 cases we had the pH values. Results: Fifteen (39.5%) newborns had cTnT >= 0.09 ng/ml and 20 (43.5%) had a pH < 7.20. Fetuses who developed acidemia had fewer fetal movements per hour in cCTG (median 2 vs. 15, P=0.019). There was a positive correlation between pH and the number of fetal movements per hour (rho 0.35, P=0.019) and basal fetal heart rate (rho 0.37, P=0.011), and a negative correlation between pH and the zscore of pulsatility index for veins (PIV) of ductus venosus (rho= -0.31, P=0.036). The logistic regression analysis identified the z-score of PIV of ductus venosus (P=0.023) and basal fetal heart rate (P=0.040) as independent variables associated with acidemia at birth. The occurrence of fetal myocardial injury was significantly associated with z-score of PI of umbilical artery (median 8.8 vs. 4.0, P=0.003), PIV of ductus venosus (median 2.6 vs. -1.4, P=0.007), basal fetal heart rate (median 146 vs. 139 bpm, P=0.033), number of accelerations between 10-15 bpm (median 0 vs. 1, P=0.013), duration of episodes of low variation (median 21 vs. 10 min, P=0.038) and short-term variation (STV) (median 3.7 vs. 6.1 ms, P=0.003). We observed a positive correlation between the value of cTnT in the umbilical cord and basal fetal heart rate (rho=0.33, P=0.042), and a negative correlation between cTnT and STV (rho=-0.37, P=0.021). Logistic regression identified the STV as an independent predictor for myocardial damage (P=0.01), and STV <= 4.3 ms was the best cutoff to predict the event (sensitivity 66.7% and specificity of 91.3%). Conclusion: In pregnancies with placental insufficiency detected before the 34th week of gestation, the PIV of ductus venosus and basal fetal heart rate analyzed by cCTG are independent variables associated with acidemia at birth; and the STV is the parameter that best predicts fetal myocardial injury. The cCTG is an important tool in the management of fetuses with placental insufficiency, especially when associated with other diagnostic methods such as Doppler
Ortigosa, Cristiane. "Doppler venoso fetal na insuficiência placentária: relação com o pH no nascimento". Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/5/5139/tde-10072012-161319/.
Pełny tekst źródłaOBJECTIVE: This study, conducted in high-risk pregnancies with placental insufficiency, aims to avaliate blood flow in the fetal left portal vein (LPV), umbilical vein (UV) and ductus venosus (DV), and establish which parameters are associated with acidemia at birth. METHOD: A prospective research involving 58 pregnant women, classified according to the presence or absence of the diagnosis of fetal acidosis at birth, according to pH in the blood of the umbilical artery, consisting of: Group I: 26 cases (acidemia, pH <7,20) and Group II: 32 cases (normal pH, pH 7,20). Exclusion criteria were patients who had postnatal diagnosis of abnormality of the newborn and those in which the pH measurement was not obtained at birth. The following Doppler variables of LPV and UV were compared between the groups: TAMxV (Time Averaged Maximum Velocity) (cm/s) zeta-score, Q/kg (blood flow per kg of fetal weight) (ml/min/kg) and presence of pulsatility; and DV pulsality index for veins (PIV) zetascore. RESULTS: LPV TAMxV zeta-score (rho=0.392, P=0.002) and Q/kg (rho=0.274, P=0.037), DV PIV zeta-score (rho=-0.377, P=0.004) and UV Q/kg (rho=0.261, P=0.048) showed significant correlation with pH at birth. Performing the multivariate logistic regression analysis, the independent variables that remained in the final model were: TAMxV of LPV zeta-score (OR=0.41; IC95% 0.25 a 0.71; P=0.001) and reverse flow in LPV (OR=0.004; IC95% 0.00 a 0.15; P=0.003), both showing a protective effect to reduce the risk of acidemia. With this model, it was found that 74,1% of cases are correctly classified to birth acidemia. CONCLUSION: by analysis of fetal venous Doppler in placental insufficiency we found that acidemia at birth (pH <7.20) is independently associated with reverse flow in the LPV and LPV TAMxV z-score, both showing a protective effect with reduced risk for the event
Takeno, Marisa Akemi. "Avaliação ultrassonográfica das dimensões do timo fetal na insuficiência placentária". Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/5/5139/tde-26052014-090506/.
Pełny tekst źródłaIntroduction: thymus gland is an important lymphoid organ involved in immune response. Studies have shown that during fetal life, thymus atrophy is part of an adaptive response to a compromised intrauterine environment, like chronic malnutrition due to placental insufficiency. This may explain the association between intrauterine growth restriction and later altered immune function. Objective: to evaluate fetal thymus by ultrasonography in pregnancies with placental insufficiency and compare to high risk pregnancies without placental insufficiency and low risk pregnancies. Methods: a prospective study with 30 pregnancies with placental insufficiency (umbilical artery Doppler with pulsatility index > p95), compared to 30 high risk pregnancies and 30 low risk pregnancies (control group). The inclusion criteria were: gestational age ranging from 26 to 37 weeks, singleton pregnancies, absence of fetal malformations, intact membranes, not in labor, no signs of maternal or fetal infection, and no corticotherapy before the ultrasound evaluation. Fetal thymus was identified in its interface with the lungs, at the level of the tree-vessel view of the fetal thorax. Three measures of thymus transverse diameter (TD) and perimeter (P) were made, and the media were converted into zeta score according to the gestational age. Head circumference (HC) and femur length (F) were also measured and used in the calculation of the relations TD/F, TD/HC, P/F, P/HC. Results: the group with placental insufficiency presented median of umbilical artery PI elevated, when compared to high risk pregnancies and low risk pregnancies (4.6 vs. -0.5 vs. -0.2, p < 0.001). Fetal thymus measurements were significantly (p < 0.001) lower in pregnancies with placental insufficiency [TD zeta score (media=-0.69; SD=0.83) and P zeta score (media=-0.73; SD=0.68)] when compared to high risk pregnancies [TD zeta score (media=0.49; SD=1.13) and P zeta score (media=0.45; DP=0.96)] and control group [TD zeta score (media=0.83; SD=0.85) and P zeta score (media=0.26; SD=0.89)]. There was significant difference (p < 0,05) in the relations studied among the groups: pregnancies with placental insufficiency (TD/HC=0.10, P/F=1.32 e P/HC=0.26), high risk pregnancies (TD/HC=0.11, P/F=1.40, P/HC=0.30) and control group (DT/HC=0.11, P/F=1.45, P/HC=0.31). Conclusion: fetal thymus measurements are reduced in pregnancies with placental insufficiency, suggesting that it is a fetal adaptive response for adverse environment
Costa, Verbenia Nunes. "Detecção da disfunção cardíaca fetal pelo BNP no sangue de cordão umbilical no nascimento e sua relação com a hemodinâmica fetal na insuficiência placentária". Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/5/5139/tde-09092013-162526/.
Pełny tekst źródłaThis study examined the hypothesis that fetal hemodynamic changes are associated with fetal myocardial dysfunction in pregnancies complicated by placental insufficiency. The objective was to study the correlation between the concentrations of cardiac natriuretic peptide type B (BNP) in umbilical cord blood at birth and fetal Doppler parameters, as well as the pH at birth. Methods: A prospective crosssectional study with the following inclusion criteria: pregnant women with a single fetus, placental insufficiency characterized by increased pulsatility index (PI) of the umbilical artery (UA), intact membranes and absence of fetal abnormalities. There were excluded from the study cases with postnatal diagnosis of abnormality of the newborn and those in which the blood analysis was not performed. The following Doppler parameters were analyzed: UA PI, middle cerebral artery (MCA) PI, cerebroplacental ratio (CPR) and ductus venosus (DV) PI for veins (PIV). The Doppler parameters were converted into zeta score. Blood samples were obtained from the umbilical cord immediately after delivery to measure the pH of the umbilical artery and the BNP. Results: Thirty two pregnancies with placental insufficiency were included, 21 (65%) with positive diastolic flow and 11 (35%) with absent or reversed end diastolic flow in the UA. The concentration of BNP correlated significantly with: UA-PI z-score (rho = 0.43, P = 0.016); CPR z-score (rho = -0.35, P = 0.048); DV-PIV zscore (rho = 0.61, P <0.001), pH at birth (rho = -0.39, P = 0.031) and gestational age (rho = -0.51, P = 0.003). In the multiple regression analysis, antenatal parameters were included and DV-PIV z-score (P = 0.008) was found to be independent parameter correlated with BNP at birth. The correlation between BNP and DV-PIV zscore is represented by the regression equation Log [BNP] = 2.34+0.13*DV (F=18.8, P <0.001). The correlation between BNP and pH at birth is represented by the regression equation Log [BNP] = 21.36-2.62*pH (F=7.69, P = 0.01). Conclusion: The results suggest that fetal cardiac dysfunction identified by BNP concentrations at birth correlated independently with changes in the DV PIV, and correlated negatively with pH values at birth
Higgins, Josephine Suzanne. "Maternal hypoxia and the mouse placenta : morphological, transport and mitochondrial phenotype". Thesis, University of Cambridge, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.709222.
Pełny tekst źródłaNiigaki, Juliana Ikeda. "Dopplervelocimetria da artéria cerebral média fetal na predição da acidemia no nascimento em gestações com insuficiência placentária". Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/5/5139/tde-08042014-090931/.
Pełny tekst źródłaObjectives: To evaluate the relationship between middle cerebral artery (MCA) parameters and acidemia at birth, in pregnancies complicated by placental insufficiency. Methods: The study was performed as a prospective cross-sectional analysis of Doppler measurements in 91 patients with the diagnosis of placental dysfunction by abnormal umbilical artery (UA) Doppler (pulsatility index [PI] > p95). Inclusion criteria were: singleton pregnancy, intact membranes, abscence of fetal congenital or chromosomal abnormalities. The Doppler parameters analyzed were: UA PI, MCA PI, MCA peak systolic velocity (PSV), cerebroplacental ratio (CPR) and pulsatilility index for veins (PIV) of ductus venosus (DV). It was analyzed the last assessment obtained right before birth or the antenatal steroids. Umbical artey blood samples were collected at birth, and acidemia was defined as pH below 7.20. Results: Forty seven (51.6%) newborns had acidemia at birth. Those who developed acidemia showed a UA PI z-score significantly higher (median 2.1 vs 1.7, p = 0.014), as well as a higher proportion of cases with absent or reverse end diastolic flow (51.0% vs 31.8%, p = 0.006). Regarding the MAC, the PI z-score was significantly lower in cases with pH < 7.20 (median -2.7 vs. -2.1, p = 0.042), but concerning PSV z-score, no significant relation between the groups could be established (p = 0.051).The acidemia at birth was associated with lower values of CPR (median 0.5 vs 0.7, p = 0.006), but not with its z-score (p = 0.055). In relation to the venous territory, greater values of DV PIV z-score were associated with acidemia (median 2.4 vs 0.6, p = 0.015).The correlation analysis between the pH values at birth and the Doppler measurements, a significant correlation was observed between the pH at birth and UA PI z-score (rho = -0.31, p = 0.003 ), MCA PI z-score (rho = 0.26, p = 0.012), CPR z-score (rho 0.25, p = 0.015), PIV DV zscore (rho = -0.32, p = 0.002), and PSV MCA MoM (rho = -0.21, p = 0.042). Logistic regression identified the UA PI z-score and the MCA PI z-score as independent predictors for acidemia at birth, correctly classifying 67.03% of cases. Conclusion: In pregnancies with placental insufficiency, the UA PI and the MCA PI are independent predictors associated with acidemia at birth. This study reinforces that the degree of placental insufficiency and the fetal adaptation capacity are directly related to acidemia at birth
Canfield, John. "Investigating the Role of the RNA Binding Protein LIN28 in the Human Placenta: Implications for Preeclampsia". Scholar Commons, 2018. https://scholarcommons.usf.edu/etd/7483.
Pełny tekst źródłaPhillips, Thomas Ernest James. "Alterations to the developing brain after exposure to signals released from the placenta due to a hypoxic insult and preventative treatments". Thesis, University of Bristol, 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.715796.
Pełny tekst źródłaKimball, Rebecca Lutz. "The Role of Hypoxia on Pyruvate Kinase M2, mammalian Target of Rapamycin, Mitochondrial Function, and Cell Invasion in the Trophoblast". BYU ScholarsArchive, 2016. https://scholarsarchive.byu.edu/etd/5723.
Pełny tekst źródłaAdelman, David Matthew. "Hypoxia and hematopoietic, placental and cardiovascular development /". 2001. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:3019887.
Pełny tekst źródłaBlack, Amy Maxine. "Broccoli sprout supplementation during placental insufficiency confers structural and functional neuroprotection to the fetal rat". Master's thesis, 2010. http://hdl.handle.net/10048/913.
Pełny tekst źródłaA thesis submitted to the Faculty of Graduate Studies and Research in partial fulfillment of the requirements for the degree of Master of Science, Centre for Neuroscience. Title from pdf file main screen (viewed on January 27, 2010). Includes bibliographical references.
Racano, Antonella. "The Role and Regulation of Factor Inhibiting HIF (FIH) in Normal and Pathological Human Placentae". Thesis, 2010. http://hdl.handle.net/1807/24624.
Pełny tekst źródłaPringle, Kirsty Gay. "Insulin-like growth factor-II and its role in blastocyst development, implantation and placentation". 2008. http://hdl.handle.net/2440/57513.
Pełny tekst źródłahttp://proxy.library.adelaide.edu.au/login?url= http://library.adelaide.edu.au/cgi-bin/Pwebrecon.cgi?BBID=1326731
Thesis (Ph.D.) -- University of Adelaide, School of Paediatrics and Reproductive Health, 2008
Bibeau, Karine. "Hypoxie placentaire et atteinte surrénalienne foetale dans un modèle de restriction de croissance intra-utérine chez le rat". Thèse, 2008. http://hdl.handle.net/1866/6511.
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