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Melvin, Alison Jane. "Phospholipid fatty acid composition and insulin action". Thesis, University of Leeds, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.413198.
Pełny tekst źródłaWilliams, Anest. "Lipid profilling of polyunsaturated fatty acid - treated mouse brain and plasma. Investigation into polyunsaturated fatty acid (PUFA)-induced neuroprotection". Thesis, University of Bradford, 2010. http://hdl.handle.net/10454/4414.
Pełny tekst źródłaBrookes, P. S. "The proton leak and fatty acid composition of mitochondrial inner membrane phospholipid liposomes". Thesis, University of Cambridge, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.596937.
Pełny tekst źródłaSuito, Takuto. "Studies on the roles of polyunsaturated fatty acids for thermal adaptation". Kyoto University, 2019. http://hdl.handle.net/2433/242532.
Pełny tekst źródłaKyoto University (京都大学)
0048
新制・課程博士
博士(工学)
甲第21794号
工博第4611号
新制||工||1718(附属図書館)
京都大学大学院工学研究科合成・生物化学専攻
(主査)教授 梅田 眞郷, 教授 跡見 晴幸, 教授 秋吉 一成
学位規則第4条第1項該当
Smith, Scott Alan. "Effects of dietary fatty acids on cholesterol content, and fatty acid distributions in total and phospholipid fractions of mammary glands and adenocarcinomas from strain A/St mice". Virtual Press, 1986. http://liblink.bsu.edu/uhtbin/catkey/471160.
Pełny tekst źródłaRoberts, Matthew D. "Lipidomic investigations into the phospholipid content and metabolism of various kinetoplastids". Thesis, University of St Andrews, 2017. http://hdl.handle.net/10023/16983.
Pełny tekst źródłaCareaga, de Houck Maria Monica. "Part 1. Metabolism of polyunsaturated fatty acid by human platelets ; Part 2. Phospholipid composition of rat blood cells after feeding diets containing corn oil or corn/fish oil /". The Ohio State University, 1987. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487584612162702.
Pełny tekst źródłaKimura, Makoto, 眞人 木村, Susumu Asakawa i 晋. 浅川. "Comparison of community structures of microbiota at main habitats in rice field ecosystems based on phospholipid fatty acid analysis". Springer, 2006. http://hdl.handle.net/2237/12083.
Pełny tekst źródłaMorris, Stephen Michael. "The use of phospholipid fatty acid profiles to determine the diversity of soil microbial communities of managed woodland stands". Thesis, University of East London, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365987.
Pełny tekst źródłaLo, Van Amanda. "Study of the effects of docosahexaenoic acid (DHA) and a structured phospholipid containing DHA on physiological and pathological conditions of neurogenesis in vitro". Thesis, Lyon, 2017. http://www.theses.fr/2017LYSEI005/document.
Pełny tekst źródłaDocosahexaenoic acid (DHA, 22:6n-3) is an essential omega-3 polyunsaturated fatty acid (PUFA). It is specifically enriched in the brain and the retina and it is required for visual acuity, proper brain development and cerebral functions. While DHA deficiency in the brain was shown to be linked to the emergence of cerebral diseases (i.e. Alzheimer’s disease or Parkinson’s disease), studies showed that a dietary intake of omega-3 PUFA could prevent or attenuate neurologic disturbances linked with ageing or neurodegenerative diseases. In this context, it is primary to deliver DHA efficiently to the brain. Targeting the brain with DHA might offer great promise in developing new therapeutics for neurodegenerative diseases. The French host laboratory previously synthesized a stabilized form of lysophosphatidylcholine-DHA, which is main vector of DHA transportation to the brain, of structure 1-acetyl,2-docoshexaenoyl-glycerophosphocholine, patented and named AceDoPC®. Injection of AceDoPC or DHA after experimental ischemic stroke showed that both molecules also had neuroprotective effects. These potential neuroprotective effects are expected to be due, in part, to DHA conversion into oxygenated metabolites. This study aims to investigate the beneficial effects of DHA and its derived metabolites either unesterified or esterified within structured phospholipids on a model of neurogenesis in vitro under physiological or pathological conditions. The first objective of this work was then to synthesize the DHA-containing structured phospholipid AceDoPC®, DHA oxygenated derivative protectin DX (PDX) and a novel structured phospholipid of protectin: 1-acetyl,2-protectinDX-glycerophosphocholine (AceDoxyPC). The second objective was to investigate the effects of DHA, AceDoPC and PDX on neurogenesis using an in vitro model of neurogenesis, namely cultures of neural stem progenitor cells (NSPCs) derived from the adult mouse brain under physiological or pathological conditions (ischemic conditions). Following this, the third objective of this work was to identify the mechanisms involved in such response to stress induced under pathological conditions. Synthesis of the novel structured phospholipid AceDoxyPC was successfully performed by double enzymatic lipoxygenation of AceDoPC and identification of the product was possible using advanced techniques of liquid chromatography (LC)/electrospray ionization (/ESI)/mass spectrometry (/MS). Future studies on this potential neuroprotective molecule transporter are to be investigated in the near future. Neurogenesis study of cell cultures with AceDoPC showed enhanced neurogenesis compared to addition of unesterified DHA or vehicle control, especially under pathological conditions. Preliminary studies of the potential mechanisms involved in neuroprotection hinted that AceDoPC neuroprotective and regenerative effects might be due in part to its anti-oxidative effects
Dahlan, Winai. "Intravenous infusion of triacylglycerol-phospholipid complexes in man: effects on fatty acid pattern of plasma and on erythrocyte membrane lipid composition". Doctoral thesis, Universite Libre de Bruxelles, 1989. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/213206.
Pełny tekst źródłaClaassens, Sarina. "Measuring rehabilitation success of coal mining disturbed areas : a spatial and temporal investigation into the use of soil microbial properties as assessment criteria / Sarina Claassens". Thesis, North-West University, 2007. http://hdl.handle.net/10394/1295.
Pełny tekst źródłaDrerup, Samuel A. "Functional Responses of Stream Communities to Acid Mine Drainage Remediation". Ohio University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1458822356.
Pełny tekst źródłaGrim, Jeffrey Matthew. "The Effects of Acclimation Temperature on the Susceptibility of Biological Membranes in Fish Muscle to Lipid Peroxidation and the Role of Phospholipid Composition on Antioxidant Defenses in Vertebrates". Ohio University / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1282594590.
Pełny tekst źródłaVan, Niekerk Bertina Freda. "Functional and structural diversity of the microbial communities associated with the use of Fischer–Tropsch GTL Primary Column Bottoms as process cooling water / van Niekerk B.F". Thesis, North-West University, 2011. http://hdl.handle.net/10394/7284.
Pełny tekst źródłaThesis (M. Environmental Science)--North-West University, Potchefstroom Campus, 2012.
Hendricks, Luanne R. "Soil Bioavailability of Aminomethylphosphonic Acid: A Metabolite of Glyphosate". The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1592583268434087.
Pełny tekst źródłaTallman, Diana L. "Effects of long-term dietary zinc manipulation on diabetic indices and fatty acid composition of adipose tissue phospholipid and triglyceride of diet-induced obese C57BL/6J mice". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0015/MQ53122.pdf.
Pełny tekst źródłaHajarine, Mohamad. "Contributions a l'etude du metabolisme plaquettaire d'acides gras polyenoiques". Paris 6, 1987. http://www.theses.fr/1987PA066073.
Pełny tekst źródłaDempsey, Mark A. "Exotic earthworms and soil microbial community composition in a northern hardwood forest". Miami University / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=miami1259958575.
Pełny tekst źródłaMora, Oberländer Gabriel [Verfasser], Martin [Akademischer Betreuer] Fulda, Ivo [Akademischer Betreuer] FeußNer, Michael [Akademischer Betreuer] Thumm i Klaus-Armin [Akademischer Betreuer] Nave. "Pathways for phospholipid deacylation in Saccharomyces cerevisiae and their impact on fatty acid trafficking and equilibrium / Gabriel Mora Oberländer. Gutachter: Ivo Feußner ; Michael Thumm ; Klaus-Armin Nave. Betreuer: Martin Fulda". Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2011. http://d-nb.info/1042972451/34.
Pełny tekst źródłaSimoens, Christian. "Intravascular metabolism of lipid emulsions with different fatty acid pattern: influence on fatty acid profile of membrane phospholipids in target organs and cells". Doctoral thesis, Universite Libre de Bruxelles, 2011. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209776.
Pełny tekst źródłaChambaz, Jean. "Metabolisme des acides gras essentiels par les hepatocytes de rat en culture". Paris 6, 1988. http://www.theses.fr/1988PA066669.
Pełny tekst źródłaSlaughter, Lindsey C. "SOIL MICROBIAL COMMUNITY RESPONSE TO CLIMATE CHANGE: RESULTS FROM A TEMPERATE KENTUCKY PASTURE". UKnowledge, 2012. http://uknowledge.uky.edu/pss_etds/8.
Pełny tekst źródłaRahman, Md Mahbubur. "Characterization of Acyltransferases and WRINKLED Orthologs Involved in TAG Biosynthesis in Avocado". Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/etd/3519.
Pełny tekst źródłaRogerson, Madeleine. "Interactions of phospholipids with fatty acids". Thesis, University of East Anglia, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.398493.
Pełny tekst źródłaSehl, Anthony. "Impact de la forme moléculaire et supramoléculaire de vectorisation des acides gras polyinsaturés n-3 sur leur biodisponibilité : étude physico-chimique et in vivo chez le rat". Thesis, Bordeaux, 2019. http://www.theses.fr/2019BORD0065.
Pełny tekst źródłaThe latest data from the cross-sectional national French dietary study show that dietary intakes of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are significantly lower than those recommended by the French Agency for Food, Environmental and Occupational Health & Safety (ANSES). Considering their physiological roles, improving their dietary intake has became a nutritional priority. The control of the different forms of n-3 long chain polyunsaturated fatty (n-3 LC-PUFA) intake represents an interesting way to address this issue. In this context, this thesis aims at studying the influence of the molecular form (phospholipids (PL) vs triglycerides (TG)) and/or supramolecular form (continuous phase, emulsion, liposomes) of n-3 LC-PUFA towards their bioavailability.The experimental approach consisted in characterizing the different forms of n-3 LC-PUFAs by coupling various physicochemical methods (optical microscopy, granulometry, measurement of primary and secondary oxidation products, enzymatic lipolysis). The data obtained made it possible to propose some mechanistic hypothesis for the bioavailability studies conducted in rat. Thus, in a second step, the in vivo study made addresses (1) the intestinal absorption of fatty acids following a single dose of lipids and (2) the lipid tissue accretion following an 8-week diet.The data obtained from the intestinal absorption study indicate that the molecular form of n-3 LC-PUFA targeting (marine TG vs marine PL, in continuous phase) does not influence their intestinal absorption but rather their incorporation into lymphatic lipids, which are the main carriers for dietary fatty acids in the organism. Conversely, structuring marine PL (emulsion or liposomes) improves the EPA and DHA absorption, but differently according to the supramolecular form. The results concerning tissue accretion show that, after 8-week diet, the tissue enrichment in n-3 LC-PUFA is different according to the molecular form of targeting. The consumption of marine TG favours the incorporation of n-3 LC-PUFA into hepatic lipids, while the supplementation of diets with marine PL targets DHA preferentially to brain and retina.All these results show that the molecular form of targeting (PL vs TG) of n-3 LC-PUFA can be a way for managing their tissue incorporation, whereas the supramolecular organization (emulsion or liposomes) can be envisaged to monitor their intestinal absorption
Dempsey, Mark Austin. "Exotic earthworms and soil microbial community composition in a northern hardwood forest". Oxford, Ohio : Miami University, 2009. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=miami1259958575.
Pełny tekst źródłaPetkevicius, Kasparas. "The role of macrophage intracellular lipid partitioning in glucose and lipid homeostasis during obesity". Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/285429.
Pełny tekst źródłaYu, Rong. "Metabolic interactions among amino acids, phospholipids and fatty acids". Thesis, University of British Columbia, 2013. http://hdl.handle.net/2429/45211.
Pełny tekst źródłaPaavola, T. (Timo). "Associations of low HDL cholesterol level and premature coronary heart disease with functionality and phospholipid composition of HDL and with plasma oxLDL antibody levels". Doctoral thesis, Oulun yliopisto, 2019. http://urn.fi/urn:isbn:9789526223360.
Pełny tekst źródłaTiivistelmä Sepelvaltimotauti on ateroskleroosin kliininen ilmenemismuoto. Se on merkittävimpiä kuolleisuuden ja sairastavuuden aiheuttajia niin Suomessa kuin maailmalla. Parhaillakin tunnetuilla hoidoilla sepelvaltimotaudille jää huomattava jäännösriski. Plasman matala HDL-kolesterolitaso (HDL, high-density lipoprotein) on yleinen lipidipoikkeavuus varhaista sepelvaltimotautia sairastavilla ja myös eräs metabolisen oireyhtymän, eli keskivartalolihavuuteen liittyvän ateroskleroosin riskitekijäkasauman, komponentti. Tässä väitöskirjassa tutkittiin matalan HDL-kolesterolitason ja varhaisen sepelvaltimotaudin fenotyyppiä kahdessa pohjoissuomalaisessa sukuaineistossa. Tavoitteena oli löytää uusia biologisia tekijöitä fenotyypin kohonneen sepelvatimotautiriskin taustalta. Ensimmäisen aineiston henkilöiden plasmasta mitattiin vasta-ainetasoja (IgG, IgM, IgA) LDL-hiukkasten (LDL, low-density lipoprotein) kokeellisia hapettuneita epitooppeja (malonidialdehydi-asetaldehydi-modioitu ja kuparilla hapetettu LDL) vastaan. Toisessa aineistossa mitattiin henkilöiden HDL-fraktioiden (kokonais-HDL, HDL2 ja HDL3) kykyä saada aikaan kolesterolin ulosvirtausta kokeellisesta THP-1 vaahtosolumallista. Lisäksi heidän HDL-fraktioidensa (HDL2, HDL3) fosfolipidikoostumus mitattiin nestekromatografi-massaspektrometri-laitteistolla. Vasta-ainetasot eivät liittyneet sepelvaltimotautiin tai HDL-kolesterolitasoon. Sen sijaan kolesterolin ulosvirtaus HDL2-fraktioon oli selkeästi alentunut sepelvaltimotaudissa, mikä liittyi potilaiden pieneen HDL-kolesterolipitoisuuteen. Alentunut ulosvirtaus HDL2-fraktioon liittyikin ensisijaisesti metaboliseen oireyhtymään. HDL-fraktioiden fosfolipidikoostumus erosi terveiden ja sairaiden välillä. Esimerkiksi metabolisessa oireryhtymässä tunnusomaista oli lysofosfatidyylikoliinien ja fosfatidyylikoliinien sisältämän palmitiinihapon, palmitoleiinihapon tai oleiinihapon suurentunut määrä suhteessa niiden sisältämän linoleenihapon määrään. Loppupäätelmä on, että matalan HDL-kolesterolitason ja varhaisen sepelvaltimotaudin fenotyypin HDL-fraktio on sekä toiminnaltaan että koostumukseltaan muuntunut. Erityisesti HDL2-fraktion kyky saada aikaan kolesterolin ulosvirtausta ja näin ollen sen monet toiminnalliset ominaisuudet voivat olla alentuneet. Fenotyypin HDL:n fosfolipidikoostumuksessa on monia tunnusomaisia piirteitä, joita havaittiin sekä HDL2- että HDL3-fraktiossa
Lee, Jong-Sook Kwon. "Effects of dietary fatty acids on platelet function, plasma thromboxane B? levels, and fatty acid composition of plasma and platelet phospholipids /". The Ohio State University, 1989. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487672245900036.
Pełny tekst źródłaLin, Yun. "Industrial Applications of Plant Secondary Metabolites". The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1492554952029414.
Pełny tekst źródłaAreda, Martha. "The role of omega-3 fatty acids in the treatment of schizophrenia through modification of membrane phospholipids". Thesis, Linnéuniversitetet, Institutionen för kemi och biomedicin (KOB), 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-55601.
Pełny tekst źródłaÄnda sedan tillkomsten av hypotesen som länkade etiologin av schizofreni med onormala sammansättningar av membranfosfolipider, har bevis för nedsatt membranfettsyror hos patienter med schizofreni ökat. Detta har lett till genomförandet av flera studier för att utvärdera effekten av omega-3 supplement i modifieringen av membranfosfolipider och i behandling av schizofreni. De två viktigaste omega-3 klasserna, EPA och DHA, spelar en viktig roll i membran. Detta projektarbete granskar de omega-3 studierna och sammanfattar deras resultat. Åtta originalartiklar (nio studier) granskades. Sex av nio studier mätte nivåer av RBC membranfettsyror och alla sex studierna rapporterade en signifikant ökning av EPA efter EPA behandling. Två studier rapporterade ökad DHA efter omega-3 och DHA behandling, respektive. En studie observerade en dosberoende ökning i DHA efter EPA behandling. Förbättrade symtom observerades i sju studier, medan en studie fann en försämring av symtom hos patienter med låg baseline PUFA. Av de sex studier som utvärderade sambandet mellan symtomförändring och förändring i membranfettsyror, hittade två studier samband mellan ökad EPA och symtomförbättring. En studie rapporterade en ökad AA i samband med förbättrade symtom, i motsats till en annan studie, som fann ett samband mellan ökad AA och försämrade symtom. Slutsatsen från detta projektarbete är att EPA tillägg ökar nivåer av EPA i membranfosfolipider; men dess terapeutiska effekt vid schizofreni kräver ytterligare utredning med hjälp av större studier.
Portolesi, Roxanne, i roxanne portolesi@flinders edu au. "Fatty acid metabolism in HepG2 cells: Limitations in the accumulation of docosahexaenoic acid in cell membranes". Flinders University. Medicine, 2007. http://catalogue.flinders.edu.au./local/adt/public/adt-SFU20070802.103146.
Pełny tekst źródłaBouazizi, Hana. "Rôle des lipides dans l’infestation, la virulence, et la transformation des promastigotes en amastigotes et implication des acides gras dans la pathogénie de Leishmania". Thesis, Lyon, 2018. http://www.theses.fr/2018LYSE1104.
Pełny tekst źródłaLeishmania parasites are the causative agents of visceral (LV), mucocutaneous (LM) or cutaneous (LC) leishmaniasis in humans, canine leishmaniasis in dogs (CanL), and leishmaniases in other mammals .The parasites are phagocytosed by human and animal macrophages where they will transform from promastigote to amastigote. We identified and analyzed the lipids involved in the transformation process in the Leishmania donovani complex. Four classes of lipids, phospholipids (PL), free fatty acids (FA), triglycerides (TG) and sterols were studied.Similarly, we analyzed the fatty acid composition of total lipids in nine Tunisian Leishmania isolates, including five strains of L. infantum (four human and one canine), two strains of L. major and two strains of L. tropica.In our early work, the fatty acid composition of total lipids was analyzed and our results show an increase in fatty acids and cholesterol and a decrease in triglycerides and ergosterol during the transformation of promastigotes into amastigotes. For phospholipid classes, we found an increase in sphingomyelin and phosphatidylserines and a decrease in phosphatidylinositols and lysophosphatidylethanolamines during processing. For the fatty acid composition, a significant increase of n-7 fatty acids was observed in amastigotes, as for n-6 total fatty acids, they decreased in PLs. Several changes have also been observed in TG and free fatty acids, in particular, n-7 and 20: 4n-6 fatty acids have been greatly increased, whereas n-9 fatty acids and n-6 ??precursors have been significantly increased. decreased.The study of the fatty acid composition of the 9 Tunisian strains of Leishmania confirmed, in the first place, our results found in our first works concerning the presencevery high proportions of 18: 2n-6 against low proportion of AA (20: 4n-6) as well as the absence or very low proportion of 18: 3n-3.In addition, the comparison of the fatty acid compositions of the three species studied: L. infantum, L. major and L. tropica showed that L. major had a higher proportion of 14: 0 (myristic acid), 18: 3n- 6 (gamma-linoleic acid) and a lower proportion of n-3, including18: 3n-3 (alpha-linoleic acid) and 22: 6n-3 (docosahexaenoic acid) compared to L. infantum and L. tropica. After supplementation of oleic acid (AO), arachidonic acid (AA) and docosahexaenoic acid (DHA) on two L. infantum strains used to infect macrophages: a MON-24 isotype responsible for cutaneous and a MON-1
Newman, Ronald Edward. "Modulation of avian metabolism by dietary fatty acids". University of Sydney. Veterinary Science, 2000. http://hdl.handle.net/2123/799.
Pełny tekst źródłaBaker, Julie Taylor Craig-Schmidt Margaret C. "Interactive effects of fish oil and methylmercury on the fatty acid profile of adult rat forebrain phospholipids". Auburn, Ala., 2007. http://repo.lib.auburn.edu/2007%20Fall%20Theses/Baker_Julie_23.pdf.
Pełny tekst źródłaCosta, Ana Cláudia Marques Lopes Soares da. "The effect of dietary fatty acid on breast cancer lipidome". Master's thesis, Universidade de Aveiro, 2014. http://hdl.handle.net/10773/13294.
Pełny tekst źródłaBreast cancer is a complex heterogeneous disease and one of the leading causes of death among women. Many studies have tried to determine if saturated, monounsaturated and polyunsaturated fatty acids (FA) have different effects on the development of breast cancer. However, the role of different dietary FAs in lipidome of breast cancer cells is not completely understood. The aim of this work was to establish if lipidome of breast cancer T47-D cell line differs with different dietary FAs and correlate this findings to effects in proliferation and apoptosis. The lipid changes in lipidome induced by the presence of 1 μg/mL oleic acid (OA1) or 1 or 2 μg/mL linoleic (LA1 or LA2, respectively) acid in vitro were study through a lipidomic analysis, based on techniques such as TLC and GC-MS. TLC allowed the separation and quantification of Phospholipid (PL) classes and GC –MS allowed the separation and quantification of FAs. TGs and CHL were quantified. Also, cell viability and apoptosis were evaluated. PL class analysis showed significant alterations in phosphatidylethanolamine (PE), phosphatidylserine (PS) in the medium with LA1 or LA2, respectively and lysophosphatidylcholine (LPC) in the medium with OA1. GC-MS showed an increase of 18:2 in the treatment with LA. Further TG showed a decrease on LA2 treatment and viability and apoptosis assays showed that LA1 and LA2 stimulate cell growth and OA2 stimulated apoptosis, respectively. This work contributes to a better understanding of the influence of dietary FAs on the lipidome of T-47D cells and shows that alterations in cellular lipidome are associated to changes in cell number and apoptosis. These findings may lead to new perspectives in the identification of specific targets that may be helpful to understand the process behind breast cancer growth. However, more studies are necessary to conclude about how different lipid molecules promote these effects.
O cancro da mama é uma doença heterogênea complexa e uma das principais causas de morte entre as mulheres. Muitos estudos têm tentado determinar se ácidos gordos (FA) saturados, monoinsaturados e polinsaturados têm efeitos diferentes sobre o desenvolvimento de cancro da mama. No entanto o papel dos diferentes FAs da dieta no lipidoma de células de cancro da mama não é completamente compreendido. O objetivo deste trabalho foi avaliar se o lipidoma da linha celular T-47D de cancro da mama se altera com diferentes FAs da dieta e correlacionar essas alterações com efeitos na proliferação e apoptose celulares. As alterações lipídicas induzidas pela presença de 1 ug / mL de ácido oleico (OA1) ou 1 ou 2 ug / ml de ácido linoleico (LA1 ou LA2, respetivamente) de ácido in vitro foram estudadas através de uma análise lipidómica com base em técnicas tais como TLC, para a separação e quantificação de classes de fosfolípidos (PLs) e GC-MS, para separação e quantificação dos FAs. Os triglicerídeos (TGs) e colesterol (CHL) totais foram quantificados utilizando métodos colorimétricos. Além disso, a viabilidade celular e a apoptose também foram avaliadas. A análise de classes de PL permitiu observar alterações significativas nas classes de fosfatidiletanolamina (PE), fosfatidilserina (PS) nas células suplementadas com LA1 e LA2, respetivamente, e lisofosfatidilcolina (LPC) nas células suplementadas com OA1. Observou-se ainda um aumento do FA 18:2 no tratamento com LA. Além disso, os TGs mostraram uma diminuição no tratamento com LA2. Os ensaios de viabilidade e apoptose mostraram que LA1 e LA2 estimulam o crescimento celular e que OA2 estimula a apoptose. Este trabalho contribui para uma melhor compreensão da influência dos FAs da dieta no lipidoma de células T-47D e mostra que as alterações no lipidoma celular estão associadas a um aumento do metabolismo e crescimento celular nas células suplementadas com LA e a um aumento da apoptose em células suplementadas com OA. Essas descobertas podem levar a novas perspetivas na identificação de estratégias específicas que podem ser úteis para compreender o processo envolvido na progressão do cancro da mama. No entanto, mais estudos são necessários para concluir sobre como os diferentes lípidos podem promover estes efeitos.
Hess, Holly Aline. "Prophylactic enrichment of enterocyte phospholipids with polyunsaturated fatty acids fed to suckling piglets". NCSU, 2006. http://www.lib.ncsu.edu/theses/available/etd-08222006-165814/.
Pełny tekst źródłaCuster, Jenny Elise. "Phospholipids and Glycolipids of the Oral Bacterium Streptococcus mutans UA159". University of Cincinnati / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1307442038.
Pełny tekst źródłaHughes, S. J. "The control of fatty acid composition of membrane phospholipids in the genetically obese (ob/ob) mouse". Thesis, University of Southampton, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.370803.
Pełny tekst źródłaGridley, Shelly M. "The effect of dietary fatty acids on cholesterol/phospholipid ratios and fatty acids in plasma membranes of spontaneous mammary tumors from strain A/ST mice". Virtual Press, 1989. http://liblink.bsu.edu/uhtbin/catkey/722452.
Pełny tekst źródłaDepartment of Biology
BURGNELLE-MAYEUR, CAMILLE. "Influence du gene de nanimse (dw) sur le metabolisme lipidique de la poule pondeuse". Paris 7, 1988. http://www.theses.fr/1988PA077024.
Pełny tekst źródłaCrossman, Zoë Maretta. "Investigation of methane oxidising bacteria in soils by ¹³C labelling of phospholipid fatty acids". Thesis, University of Bristol, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271814.
Pełny tekst źródłaBolivar, Gonzalez Juan. "Interaction of fatty acids and phospholipids with multiple binding sites on the potassium channel KcsA". Thesis, University of Southampton, 2011. https://eprints.soton.ac.uk/334068/.
Pełny tekst źródłaSolow, Steven P. "Characterization of A transcriptional Attenuator in The rpmf-Plsx-Fab Operon of Escherichia coli K-12". Diss., Virginia Tech, 1997. http://hdl.handle.net/10919/30536.
Pełny tekst źródłaPh. D.
Jin, Yang. "Time kinetics of fatty acids changes in total lipids and phospholipids of A. franciscana following enrichment and starvation, with a main focus on docosahexaenoic acid (DHA)". Thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for biologi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-21424.
Pełny tekst źródłaBertram, Janet. "Effects of cow urine and its constituents on soil microbial populations and nitrous oxide emissions". Diss., Lincoln University, 2009. http://hdl.handle.net/10182/1334.
Pełny tekst źródłaGarcia, Cyrielle. "Molécules bioactives du lait maternel, relation à l'alimentation et application à la prise en charge du nouveau-né prématuré". Thesis, Aix-Marseille 2, 2011. http://www.theses.fr/2011AIX20732.
Pełny tekst źródłaHuman milk is considered as the gold standard to newborn development. However, in case of very preterm infants who have particularly high nutrients needs, it does not always provide optimal quantities of several bioactive molecules, due to composition or supply conditions.We investigated the relationship between current maternal nutrition and polyunsatured fatty acids (PUFA) composition of human milk. Human milk from mothers of South and North-West of France had imbalance PUFA composition to the detriment of n-3 PUFA, especially docosahexaenoic acid (DHA). This was linked to low consumption of fish and seafood products, and to an important n-6 PUFA intake.A second part of our work was focused on bioactive compounds of human milk and newborn intestinal development. Nutritional care of preterm infants leads to low intake of bioactive compounds (PUFA n-3, phospholipids and plasmalogens, sCD14, acid sphingomylinase), insufficient to cover the needs of HAD and to ensure optimal intestinal health during the first weeks of life. A shorter time to reach digestive maturity was associated with PUFA consumption during the first two weeks of life, and with phospholipids (sphingomyelin and plasmalogens) from the second week. sCD14 intake by preterm fed only with donor human milk was inversely correlated with digestive maturity time. This molecule influences the inflammatory response of fœtal intestinal cells to chronic bacterial stimulation.We had also investigated the physicochemical properties of milk from different animal species potentially interesting for improving infant formula or milk fortifier. Camel milk showed sphingomyelin and plasmalogen contents close to human milk. Technological treatments, such as pasteurisation or homogenisation, lead to alteration of milk properties, either in bioactive molecules content (sCD14, acid sphingomyelinase) or in fat globule structure.In conclusion, this work provides new possibilities for the conception of infant formula and fortifier to improve newborn care
Andersson, Agneta. "Fatty Acid Composition in Skeletal Muscle : Influence of Physical Activity and Dietary Fat Quality". Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2001. http://publications.uu.se/theses/91-554-5078-4/.
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