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Artykuły w czasopismach na temat „Philippe Le Bas”

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Data publikacji: 1 lutego 2025

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1

Sécardin, Olivier. "« Le traducteur est un "chercheur" d’un genre particulier »". RELIEF - Revue électronique de littérature française 15, nr 1 (7.07.2021): 126–55. http://dx.doi.org/10.51777/relief10888.

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Philippe Noble est traducteur littéraire. On lui doit notamment la traduction d’œuvres d’Etty Hillesum, Harry Mulisch et Cees Nooteboom. Après avoir mené une carrière à l’Université, Philippe Noble s’est engagé au service des Affaires étrangères et de la diplomatie culturelle – il a été conseiller culturel à La Haye (2000-2004) et à Vienne (2008-2011), directeur de la Maison Descartes et du Réseau franco-néerlandais. Il est aussi directeur de la collection « lettres néerlandaises » chez Actes Sud. Nous nous sommes entretenus avec lui à propos de son travail de « médiateur culturel » entre la France et les Pays-Bas. L’entretien est suivi d’une bibliographie complète des traductions réalisées par Philippe Noble.

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Vermeir, René. "A latere principis. Le Conseil Suprême des Pays-Bas et de Bourgogne sous Philippe II, 1588-1598". Revue belge de philologie et d'histoire 88, nr 4 (2010): 1085–104. http://dx.doi.org/10.3406/rbph.2010.9582.

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Dans cet article il est question du premier Conseil Suprême des Pays-Bas et de Bourgogne à Madrid. Il fut érigé par Philippe II en 1588 et il exista jusqu’au moment où, en 1598, les Pays-Bas passèrent aux archiducs. On étudiera les facteurs qui ont mené à sa création – tardive en comparaison avec des institutions similaires au sommet de l’Empire espagnol – ainsi que la composition, les compétences et le fonctionnement effectif du Conseil. Ces analyses montrent que l’importance réelle de l’institution était très réduite mais que néanmoins tant le gouverneur général que le roi essayèrent de s’en servir pour leurs propres buts politiques.

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3

Chaunu, Pierre. "Les Pays-Bas dans l'Empire de Charles Quint et Philippe II". Histoire, économie et société 12, nr 3 (1993): 403–18. http://dx.doi.org/10.3406/hes.1993.1683.

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Uyttebrouck, André. "Phénomènes de centralisation dans les Pays-Bas avant Philippe le Bon". Revue belge de philologie et d'histoire 69, nr 4 (1991): 872–904. http://dx.doi.org/10.3406/rbph.1991.3800.

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Javier Ruiz Ibáñez, José. "La monarchie ibérique et ses exilés : les nouveaux chrétiens musulmans dans l’armée des Flandres aux XVI e - XVII e siècles". Revue du Nord 449, nr 2 (10.10.2024): 105–24. http://dx.doi.org/10.3917/rdn.449.0105.

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L’administration impériale espagnole attira un grand nombre d’exilés vers les Pays-Bas. Les ressources accumulées par le roi d’Espagne permettaient de récompenser les réfugiés employés dans l’armée ou dans la restauration spirituelle. Tel fut le destin de certains nobles musulmans nord-africains qui, après s’être réfugiés dans les domaines des Habsbourg et avoir été baptisés, cherchaient à servir pleinement Philippe II en profitant de ses gratifications. En rejoignant les forces armées, ces nobles, récompensés par des pensions, virent leur engagement renforcé. Les Pays-Bas, expérience nécessaire au cœur d’un véritable cursus honorum , faisaient partie d’un vaste réseau de circulation dont l’étape ultime était souvent située dans l’espace méditerranéen. Les trajectoires de ces réfugiés révèlent la complexité des mécanismes d’action d’une monarchie hispanique capable d’intégrer des populations d’origines diverses.

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Désos, Catherine. "La familia francesa de Philippe V d’Espagne. Essai de biographie collective". Réseaux, clientèles et associations dans les espaces hispaniques, nr 7 (20.10.2022): 41–57. http://dx.doi.org/10.57086/sources.324.

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La familia francesa de Philippe V d’Espagne. Essai de biographie collective — La familia francesa de Philippe V, premier Bourbon d’Espagne (1701-1746), est rarement mentionnée dans les ouvrages consacrés au règne de ce roi. Constituée de bas-officiers français dispersés dans les différents services de la maison du roi, elle s’installa dès 1701, avant d’être peu à peu renforcée par de nouvelles arrivées. Son étude permet de suivre les stratégies d’implantation d’une société française au sein d’une cour étrangère. Durant les premières années, on constate une progressive intégration dans un esprit de conciliation entre les différentes nationalités, tandis que, parallèlement, se développent de multiples réseaux de solidarités, par mariages et par cooptations professionnelles, qui ont pour effet de consolider la possession des charges et de créer des moyens d’entraide en cas de besoin. Mais, c’est bien l’affection portée par le roi à cette familia francesa qui explique sa pérennité : se pose alors la question de son devenir dans la seconde moitié du siècle.

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7

Vermeir, René. "L'ambition du pouvoir. La noblesse des Pays-Bas méridionaux et Philippe IV, 1621-1648". Revue du Nord 359, nr 1 (2005): 89. http://dx.doi.org/10.3917/rdn.359.0089.

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8

Le Moine, Roger. "Philippe Aubert de Gaspé ou les affaires du «bon gentilhomme»". Zone libre, nr 57 (29.02.2012): 299–321. http://dx.doi.org/10.7202/1008110ar.

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Dans son célèbre roman Les Anciens Canadiens, Philippe Aubert de Gaspé (1786-1871) par le truchement de Monsieur d'Egmont en qui on a reconnu l'auteur, veut laisser croire qu'il a été victime de « faux amis » alors qu'il a été l'artisan de son propre malheur. Dès les débuts de sa carrière d'avocat, il multiplie les dettes et vit au-dessus de ses moyens. Les expédients financiers l'amènent à des actions douteuses, puis franchement illégales envers les membres de sa famille, les clients et, dans le cadre de sa pratique professionnelle à titre de shérif, envers le gouvernement. Ses défalcations malhonnêtes contribuent notamment à la ruine de Joseph-François Perrault qui avait entrepris la mise sur pied d'écoles au bénéfice de la jeunesse du Bas-Canada. Destitué et accusé de malversation, Aubert de Gaspé se réfugie à Saint-Jean-Port-Joli. La justice met plusieurs années à l'atteindre, mais des actions sont prises contre lui. Il doit faire face à la justice et purger une peine d'emprisonnement à Québec entre 1838 et 1841.

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9

Kimball Brooker, Thomas. "The Library of Antoine Perrenot de Granvelle". Bulletin du bibliophile N° 361, nr 1 (1.01.2015): 23–72. http://dx.doi.org/10.3917/bubib.361.0035.

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Antoine Perrenot de Granvelle (1517-1586) fut l’une des figures diplomatiques les plus puissantes de son époque, ainsi que l’un des plus grands collectionneurs de livres et d’œuvres d’art. Fils de Nicolas Perrenot de Granvelle, un des deux principaux ministres des Affaires étrangères de Charles Quint, Antoine Perrenot fut destiné dès son jeune âge à une carrière diplomatique tout en occupant une position ecclésiastique très lucrative. En 1540, âgé de vingt-trois ans, il fut admis à la prêtrise et fait évêque d’Arras par le pape Paul III sur recommandation de l’empereur. Il s’agissait de l’un des postes ecclésiastiques les plus rémunérateurs des Pays-Bas espagnols. À la même date, il avait accumulé de nombreuses prébendes aux Pays-Bas et en Franche-Comté, et il continua ensuite de cumuler de nombreux bénéfices ecclésiastiques. Granvelle utilisa ses revenus très confortables pour satisfaire son goût du luxe, dont la création de l’une des plus grandes bibliothèques privées de son temps. En tant qu’évêque d’Arras, Granvelle consacra moins de temps à ses activités religieuses qu’à ses activités politiques, partageant avec son père des responsabilités gouvernementales. Charles Quint le tenait en haute estime, et Granvelle occupa beaucoup des charges de son père à la mort de ce dernier. En 1559, Philippe II nomma Granvelle conseiller et premier ministre de sa sœur Marguerite de Parme, régente des Pays-Bas, et il devint de fait le véritable chef du gouvernement de cette région. En 1559 toujours, il fut élu archevêque de Malines, puis cardinal en 1561. Après avoir été rappelé des Pays-Bas par Philippe II en 1564, et avoir passé un peu plus d’un an à Besançon, sa ville natale, Granvelle fut envoyé à Rome par le roi qui le nomma vice-roi de Naples de 1571 à 1575, où il joua un grand rôle dans les négociations qui débouchèrent sur la formation de la Sainte Ligue, qui remporta une victoire remarquable sur la flotte turque à Lépante en 1571. Rappelé en Espagne en 1575, Granvelle fut ministre de Philippe II en charge de la politique extérieure jusqu’à sa mort en 1586. Il semble bien que Granvelle ait projeté vers 1545 ou 1546 la création d’une grande bibliothèque complète digne d’un humaniste. Durant ces années trois faits déterminèrent l’étendue, la constitution et l’esthétique de la bibliothèque de Granvelle. D’abord, son bibliothécaire Antoine Morillon prépara en 1547 une liste de 1 200 éditions imprimées de textes grecs et latins, exposant ce qui devait, selon lui, constituer la bibliothèque d’un humaniste. Cette liste, l’ Index meliorum auctorum secundum artem , donnait des détails sur ce qu’une telle librairie devait contenir et pouvait servir de liste d’acquisitions. Ensuite, toujours en 1547, de nombreuses éditions imprimées de textes grecs, latins et italiens et de nombreux manuscrits grecs furent acquis et magnifiquement reliés dans plusieurs styles de reliure distinctifs à Venise, puis envoyés à Granvelle au nord des Alpes. Enfin, des principes d’ornementation des reliures furent élaborés et appliqués à la plupart des livres commandés à Venise. Ils déterminaient comment les livres seraient disposés sur les étagères : placés debout, côte à côte, la tranche visible, avec un titre en lettres d’or sur une étiquette de couleur peinte horizontalement sur la tranche. Morillon non seulement prépara l’ Index meliorum auctorum secundum artem mais il joua probablement aussi un rôle dans les deux autres étapes. Granvelle continua d’enrichir sa bibliothèque et joua un rôle de mécène auprès d’un grand nombre d’écrivains, d’imprimeurs et d’artistes durant sa carrière diplomatique. Bien que sa bibliothèque ait été largement dispersée durant les troubles aux Pays-Bas et après sa mort, la bibliothèque municipale de Besançon en conserve une partie représentative de ses livres et de sa correspondance.

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10

Nicholas, David. "Le droit privé dans les Pays-Bas méridionaux du 12e au 18e siècle. Philippe Goding". Speculum 63, nr 4 (październik 1988): 927–29. http://dx.doi.org/10.2307/2853560.

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11

Bühler, Theodor. "Philippe Godding, Le droit privé dans les Pays-Bas méridionaux du 12e au 18e siècle". Zeitschrift der Savigny-Stiftung für Rechtsgeschichte: Germanistische Abteilung 106, nr 1 (1.08.1989): 412–13. http://dx.doi.org/10.7767/zrgga.1989.106.1.412.

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12

Cauchies, Jean-Marie. "La signification politique des entrées princières dans les Pays-Bas: Maximilien d'Autriche et Philippe le Beau". Publications du Centre Européen d'Etudes Bourguignonnes 34 (styczeń 1994): 19–35. http://dx.doi.org/10.1484/j.pceeb.2.302362.

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13

Schmitt, Jean-Claude, i Jérôme Baschet. "La «Sexualité» du Christ". Annales. Histoire, Sciences Sociales 46, nr 2 (kwiecień 1991): 337–46. http://dx.doi.org/10.3406/ahess.1991.278949.

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Emile Mâle déjà avait noté comment, à partir de 1260 environ, les images de l'Enfant Jésus tenu par sa mère laissent progressivement apercevoir les genoux puis les cuisses du bébé. Dès le XIVe siècle, sa nudité complète s'exhibe, soulignée parfois par un attouchement du sexe, accompli généralement soit par l'enfant lui-même, soit par sa mère. Cette ostentatio genitaliuma été expliquée par Émile Mâle lui-même et par d'autres comme la marque d'un progrès du « réalisme » ou du « naturalisme » dans l'art du Bas Moyen Age et de la Renaissance, ou encore d'un essor du «sentiment de l'enfance », selon les termes de Philippe Ariès : de plus en plus, les artistes auraient voulu figurer l'Enfant Jésus sous les traits et avec les gestes, même les plus indiscrets, des petits enfants réels.

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14

Scheid, John. "Rome au Collège de France entre la Révolution et le XXe siècle. Une évolution rapide". Revue de Synthèse 141, nr 3-4 (16.03.2021): 163–88. http://dx.doi.org/10.1163/19552343-14000039.

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Résumé Parmi les nouvelles chaires créées au Collège de France au XIXe siècle dans le domaine des langues classiques, apparurent en 1861 et en 1877 l’Épigraphie latine et l’Épigraphie grecque. Il s’agissait de création de chaires. Pour la est conservé un dialogue entre l’Institut, le Collège de France et le ministère de l’Instruction publique, avec l’approbation de l’Empereur. À l’arrière-plan de la création ministérielle, on devine l’ombre de Philippe Le Bas et du projet de Corpus des inscriptions latines organisé selon les normes définies par Theodor Mommsen, qui avait réuni du temps du ministère d’Abel Villemain des Français, des Allemands et des Italiens. Quant à la chaire d’Épigraphie grecque, la seconde, les lettres de justification de sa création en apportent la preuve : elles décrivent l’activité épigraphique telle que les concepteurs du Corpus d’inscriptions berlinois l’imaginaient.

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15

Ducharme, Michel. "BERNARD, Philippe, Amury Girod. Un Suisse chez les Patriotes du Bas-Canada (Sillery, Septentrion, 2001), 255 p." Revue d'histoire de l'Amérique française 56, nr 4 (2003): 569. http://dx.doi.org/10.7202/007795ar.

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Vermeir, René. "A latere principis. Le Conseil Suprême des Pays-Bas et de Bourgogne sous Philippe II, 1588-1598". Revue belge de philologie et d'histoire 88, nr 4 (2010): 1085–104. http://dx.doi.org/10.3406/rbph.2010.7970.

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Junot, Yves. "Entre service et renégociation de la loyauté : les noblesses des Pays-Bas et Philippe II (1559-1598)". Cahiers de la Méditerranée, nr 106 (1.07.2023): 143–59. http://dx.doi.org/10.4000/cdlm.16938.

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Junot, Yves. "Les étudiants anglais à Douai et Saint-Omer (1568-1603) : réseau transnational et insertions locales du refuge catholique". Revue du Nord 449, nr 2 (10.10.2024): 125–46. http://dx.doi.org/10.3917/rdn.449.0125.

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L’activation d’un refuge de dissidents catholiques anglais dans les Pays-Bas espagnols donne naissance au modèle du collège-séminaire regroupant la diaspora ecclésiastique et universitaire dans une « dorsale académique » dont Douai et Saint-Omer deviennent des pivots. Leur but est de former de nouvelles générations cléricales et laïques pour assurer le renouvellement d’une élite catholique en Angleterre et appuyer une éventuelle succession catholique d’Élisabeth I ère . Ces groupes d’étudiants ne s’assimilent pas dans leur société d’accueil, provisoire par définition. Ils maintiennent leur spécificité par le marqueur national mais aussi confessionnel tridentin et jésuite, et par leur hispanophilie au service de la monarchie de Philippe II et des ultra-catholiques de la Ligue en France, jouant de leur implantation aux frontières de France et d’Angleterre. Leur action en réseaux transnationaux explique aussi les rejets locaux dont ils sont parfois victimes, avec leur expulsion de Douai en 1578 et leur repli de France vers Douai et Saint-Omer en 1593.

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19

Soen, Violet. "Philippe II et les anciens Pays-Bas (1555-1598). Les limites d’un gouvernement à distance dans un empire global". Histoire, économie & société 38anné, nr 3 (2019): 11. http://dx.doi.org/10.3917/hes.193.0011.

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20

Baruch, Marc Olivier. "Philippe Buton, Olivier Büttner et Michel Hastings (dir.) La guerre froide vue d’en bas Paris, CNRS Éditions, 2014, 382p." Annales. Histoire, Sciences Sociales 71, nr 01 (marzec 2016): 295–97. http://dx.doi.org/10.1353/ahs.2016.0045.

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Codaccioni, Vanessa. "Philippe BUTON, Olivier BÜTTNER et Michel HASTINGS (dir.). – La Guerre froide vue d’en bas , Paris, CNRS Éditions, 2014, 381 p." Le Mouvement Social 260, nr 3 (20.11.2017): XI. http://dx.doi.org/10.3917/lms.260.0149k.

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Bourdeu, Étienne. "Redéfinition du projet impérial ou construction d’un réseau de clients ? Les étapes allemandes du voyage du prince Philippe aux Pays-Bas (1548-1552)". Mélanges de la Casa de Velázquez, nr 42-2 (15.11.2012): 183–200. http://dx.doi.org/10.4000/mcv.4664.

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23

Lacombe, Sylvie. "F. Philippe Reid, Le monde selon Edward Ellice. Un maître tireur de ficelles à l’oeuvre au Bas-Canada, Québec, F. P. Reid éditeur, 2017, 102 p." Recherches sociographiques 59, nr 3 (2018): 500. http://dx.doi.org/10.7202/1058735ar.

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24

Edelman, Nicole. "Philippe ARTIÈRES et Muriel SALLE, Papiers des bas-fonds. Archives d’un savant du crime, 1843-1924, collection En quête d’archives, Paris, Textuel, 2009, 160 p. IBSN : 978-2-84597-334-3. 39 euros." Revue d'histoire du XIXe siècle, nr 41 (15.12.2010): 162–63. http://dx.doi.org/10.4000/rh19.4075.

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Denys, Catherine. "Philippe Bragard , Dictionnaire biographique des ingénieurs des fortifications. Pays-Bas espagnols, principauté de Liège, Franche-Comté, 1504-1713 , éditions Les Amis de la Citadelle de Namur-Presses universitaires de Namur, 2011, 482 p., 35 €". Revue du Nord 400-401, nr 2 (1.04.2014): VII. http://dx.doi.org/10.3917/rdn.400.0777g.

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26

Régibeau, Julien. "Une légation au coeur des réseaux de la monarchie de Philippe II. La légation des Pays-Bas espagnols et de la Franche-Comté près le Saint-Siège au temps de l’agent Laurent du Blioul (1573-1598)". Revue belge de philologie et d'histoire 92, nr 2 (2014): 365–412. http://dx.doi.org/10.3406/rbph.2014.8554.

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Gauthier, Joseph, Pierre Fluck i Bernard Bohly. "Sainte-Marie-aux-Mines et Steinbach (Haut-Rhin). Sainte-Marie-aux-Mines : district de Sainte-Marie-aux-Mines, secteur de l’Altenberg, lieu-dit Saint-Philippe (sites Bas-Patris, Berg Armuth/Sainte-Barbe et Charlotte) ; Steinbach : district de Steinbac". Archéologie médiévale, nr 43 (1.12.2013): 313–14. http://dx.doi.org/10.4000/archeomed.10313.

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Sommé, Monique. "Ordonnances de Philippe le Bon pour les duchés de Brabant et de Limbourg et les Pays d’Outre-Meuse. 1430-1467 , éd. Philippe GODDING, Bruxelles, Service public fédéral Justice, 2005 ; 1 vol. in-4°, 666 p. (Commission royale pour la publication des anciennes lois et ordonnances de Belgique, Recueil des ordonnances des Pays-Bas , 1re sér., 1381-1506 , 2e sect., 2). – Philippe GODDING, La législation ducale en Brabant sous le règne de Philippe le Bon (1430-1467) , Bruxelles, Académie royale de Belgique, 2006 ; 1 vol. in-8°, 139 p. ( Mémoire de la Classe des Lettres , 42). ISBN : 2-8031-0230-3. Prix : € 15,00." Le Moyen Age Tome CXIV, nr 1 (19.05.2008): LVI. http://dx.doi.org/10.3917/rma.141.0125zzd.

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Baptiste, Hervé. "Philippe Menerault , Alain Barré (dir.) Gares et quartiers de gares : signes et marges. Lille, Rennes et expériences internationales (Italie, Japon, Pays-Bas) Actes du séminaire international du 22 mars 1999 à Villeneuve-d’Ascq, Arcueil, Actes INRETS, n° 77, mars 2001". Autrepart 32, nr 4 (1.10.2004): II. http://dx.doi.org/10.3917/autr.032.0187b.

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Fernández Morales, Angélica. "Evocar atmósferas. Arquitectura suiza contemporánea y su expresión visual del proyecto". BAc Boletín Académico. Revista de investigación y arquitectura contemporánea 4 (8.07.2015): 53. http://dx.doi.org/10.17979/bac.2014.4.0.1009.

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El artículo se centra en la escena suiza contemporánea, y presenta diversos ejemplos de cómo es expresada visualmente la esencia atmosférica en el proyecto arquitectónico. El texto se estructura relacionando la atmósfera con varios aspectos: el lugar, la escala humana, la luz y el aire. Entre los arquitectos tratados se incluyen Herzog & de Meuron, Peter Zumthor, Christian Kerez, Gigon & Guyer, Miroslav Šik y Philippe Rahm. Se distinguen dos modos de expresión: los de carácter abstracto y diagramático y los que buscan la previsualización realística. En ambos casos, lo importante es la capacidad de evocar la vivencia de la arquitectura proyectada.

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Kuźniar, Adrian. "System naturalnej normatywności Philippy Foot". Etyka 36 (1.12.2003): 87–104. http://dx.doi.org/10.14394/etyka.415.

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It is a critical study of Philippa Foot’s conception of natural normativity set forth in her recent book Natural Goodness (Clarendon Press, Oxford 2001). The book is essentially devoted to two main subjects. The first one consists of presentation of a new, naturalistic and objectivistic, metaethical standpoint. When viewed from this standpoint, evaluations of characteristics and operations of all living things (including moral evaluative judgements of human features and actions) share the same structure. In virtue of that structure, goodness or badness ascribed to an individual organism are determined by the relation of that individual to its life form. The second significant theme of Natural Goodness deals with the relationship between morality and practical rationality. Goodness of an act is a necessary condition of that act being practically rational. The author’s general assessment of Ph. Foot’s book is rather negative. Her argument seems to lack methodological order, coherence and intellectual clarity. The very conception of natural normativity seems to contain a lot of fundamental flaws. It precludes, e.g. the possibility that any living thing could be evaluated as bad.

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Zayaruznaya, Anna. "Hockets as Compositional and Scribal Practice in the ars nova Motet—A Letter from Lady Music". Journal of Musicology 30, nr 4 (2013): 461–501. http://dx.doi.org/10.1525/jm.2013.30.4.461.

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The whimsical upper-voice texts of the anonymous fourteenth-century motet Musicalis/Sciencie stage an epistolary exchange between Rhetoric, Music, and a long list of French composers and singers. The letters complain that these musicians, whose ranks include Guillaume de Machaut and Philippe de Vitry, split words with rests when they write hockets. The critical tone of Musicalis/Sciencie implies that some ars nova composers must have regularly split words with hockets, while others—the motet’s composer, for one—held this to be bad practice. But since modern editions and medieval scribes alike are imprecise in the placement of text around hockets, the existence of such opposing camps seems difficult to substantiate. An analysis of text-note alignment in four sources for Apta/Flos reveals that some scribes were prescriptive in their texting of hockets, while others, like the scribe of the important Ivrea codex, were pragmatic. An awareness of these differences can lead to alternate modes of interpreting ambiguous text underlay. In the case of Philippe de Vitry’s Petre/Lugentium, shifting syllables adjacent to hockets can transform the work, highlighting carefully differentiated textural zones that are key to its structure. Such editorial intervention can in turn yield fresh insight into competing compositional approaches.

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Schmoll, Friedemann, Gerhard Hachmann i Rainer Koch. "Rezension von: Hachmann, Gerhard; Koch, Rainer (Hrsg.), Wider die rationelle Bewirtschaftung!" Schwäbische Heimat 67, nr 2 (9.02.2022): 259–60. http://dx.doi.org/10.53458/sh.v67i2.1721.

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Gerhard Hachmann und Rainer Koch (Hg.): Wider die rationelle Bewirtschaftung! Texte und Quellen zur Entstehung des deutschen Naturschutzes. Aus Anlass des 200. Geburtstags von Philipp Leopold Martin (1815-1885). Bonn-Bad Godesberg 2015 (BfN-Skripten, 417). Ca. 330 Seiten. Zahlreiche Abbildungen (SW). Gebundenes Heft. ISBN 978-3-89624-152-8.Eine pdf-Version kann bei Bundesamt für Naturschutz heruntergeladen werden unter: www.bfn.de/fileadmin/BfN/service/Dokumente/skripten/skript417.pdf

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Teichman, Jenny. "Good For and Good About". Philosophy 78, nr 1 (styczeń 2003): 115–21. http://dx.doi.org/10.1017/s0031819103000081.

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Ethical relativists and subjectivists hold that fact must be distinguished from value, ‘is’ from ‘ought’ and reason from emotion. Their distinctions have been called into question, notably by Philippa Foot (Natural Goodness 2001), also by Alasdair Macintyre (Dependent Rational Animals 1999).Reason in the form of the life sciences—ethology, biology—indicates that what is good or bad for an individual animal and its species are matters of objective fact. There is nothing relativistic about the idea that fresh meat is good for wolves and it is a fact, a paradigm fact, that polluted water is bad for dolphins. Moreover what is good for an animal is often something that is good about it. Sharp ears and great speed are good for deer and are also what makes a deer a good specimen of its kind.These general remarks apply to the human animal as well as to ‘ordinary’ animals. The good and bad discussed by moral philosophers cannot be radically different from the good and bad known through reason. But if it were it would normally be a remarkably indigent field of study.

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Bakti, Mária. "Philipp Sebastian Angermeyer. (2015) Speak English or What? Codeswitching and Interpreter Use in New York City Courts." Target. International Journal of Translation Studies 30, nr 1 (21.02.2018): 176–81. http://dx.doi.org/10.1075/target.16026.bak.

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Bosman, Frank G. "Five William Shakespeares Versus One Santa Claus; Self-Sacrifice and The Trolley Problem in the Series “The Good Place”". Religions 11, nr 7 (17.07.2020): 366. http://dx.doi.org/10.3390/rel11070366.

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The television series The Good Place (2016–2020), created by Michael Schur revolves around four humans who—after their deaths—end up in what they believe to be heaven: the “Good Place”. In reality, however, they are in a very sophisticated torture place, built and directed by demons from the “Bad Place”. During the four seasons of the series, the four humans discover the true nature of their predicament and try to reach to “real” Good Place, through—among other means—improving their moral attitude, e.g., becoming a better person by taking ethical lessons provided by one of the four, who is an actual professor of moral philosophy. During these lessons, the four discuss many ethical and philosophical notions, ideas and problems, among which is Philippa Foot’s famous 1967 thought experiment known as the Trolley Problem. The series as a whole, the author of this article argues, revolves around this impossible moral dilemma, suggesting self-sacrifice as an ultimate solution to the Trolley Problem.

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Gott, Michael. "Orienteering (through) cinéma-monde: the hubs, networks, borders, and forests of airport cinema". Contemporary French Civilization: Volume 47, Issue 1 47, nr 1 (1.03.2022): 17–45. http://dx.doi.org/10.3828/cfc.2022.2.

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This article considers a selection of films about air travel that encompass an array of voyagers from refugees to business travelers as a metaphor for cinéma-monde and its complex threads and trajectories. Through an analysis of key moments of transition, transformation, or exposition within short scenes from six films set at least in part at airports, I examine how characters and viewers orient themselves between the hubs shared by air networks and the film apparatuses that compose cinéma-monde. I also consider the ways that air networks intersect with other (terrestrial, virtual, cine-industrial) networks. The films analyzed are Des étoiles/Under the Starry Sky (Dyana Gaye, 2013, France/Belgium/Senegal), Je suis mort mais j’ai des amis/I’m Dead But I Have Friends (Guillaume Malandrin and Stéphane Malandrin, 2015, Belgium/France), Le fils de Jean/A Kid (Philippe Lioret, 2016, France/Canada), Bab el web (Merzak Allouache, 2005, France/Switzerland/Algeria), Bird People (Pascale Ferran, 2014, France), and De Nieuwe Wereld/The New World (Jaap van Heusden, 2013, Netherlands). Drawing on these examples, I propose the concept of “orienteering” as a description for how protagonists navigate narrative spaces but also as a model for how viewers and scholars might interact with films with the cinéma-monde framework.

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Courbage, Youssef, i Philippe Fargues. "Reconstitution de la fécondité passée à l'aide d'un seul recensement dans les pays à statistiques incomplètes". Population Vol. 42, nr 3 (1.03.1987): 449–68. http://dx.doi.org/10.3917/popu.p1987.42n3.0468.

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Résumé Fargues Philippe et Cour bac, E Youssef — Reconstitution de la fécondité passée à l'aide d'un seul recensement dans les pays à statistiques incomplètes. La recherche de données de substitution à celles que Ton attendrait de l'état civil s'il fonctionnait bien, a conduit de nombreux pays en développement à profiter des recensements et des enquêtes par sondage auprès des femmes d'âges féconds, pour collecter deux informations . nombres moyens d'enfants nés vivants (ou parités « P») et taux de fécondité au cours des douze derniers mois (dont on déduit la fécondité transversale cumulée « F») On dispose ainsi aujourd'hui d'une masse de statisques dont on ne savait jusqu'à présent tirer profit que dans les populations à fécondité invariable dans le temps (méthode du rapport P/F). Cet article montre comment, en inversant les hypotheses traditionnelles sur la fécondité — supposée maintenant variable — et sur les données retrospectives d'enquête — considérées comme suffisamment bonnes — ces informations peuvent refléter le déclin de la fécondité dans des populations qui ont abordé la seconde phase de leur transition démographique Une méthode nouvelle de reconstitution des taux de fécondité par groupes quinquennaux d'âges et par périodes est exposée puis appliquée aux données du recensement du Maroc (1982) Cette simulation conduit a des résultats très voisins de ceux qu'avait fournis l'Enquête Mondiale sur la fécondité.

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Lazzari, Matteo. "“A Bad Race of Infected Blood” The Atlantic Profile of Gaspar Riveros Vasconcelos and the Question of Race in 1650 New Spain". Journal of Early American History 11, nr 1 (28.04.2021): 3–25. http://dx.doi.org/10.1163/18770703-11010008.

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Abstract Based on manuscripts from the Mexican National Archive recording a 1650 Inquisition trial for astrology, this article will present a reconstruction of the story of Gaspar Riveros Vasconcelos, a “mulatto” born in Tangier, a descendant of a Portuguese father and Angolan mother. He travelled the Atlantic commercial routes – visiting Angola, Pernambuco, Cartagena de Indias, La Havana – and got involved in political discussions with Spaniards residing in mid-seventeenth century Mexico City. This period was particularly tough for Portuguese people in Spanish America, given the 1640 breach of the dynastic union of Spain and Portugal, which had been formerly achieved in 1581 by King Philipp ii. Vasconcelos’ story allows us to reflect on identity formation in time, on the concept of race, as well as on the ways in which “a persona miserable de color pardo” could deploy his agency as Afro-Portuguese in colonial Mexico society. As such, this paper aims to reconsider the relevance of individual narratives which can generate a growing awareness of the importance that Afro-descendants had in the Ibero-American world and how they could influence the process of racialization in the local context of seventeenth century New Spain.

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Swart, L., i S. Coertze. "First Record of Botrytis Flower Blight Caused by Botrytis cinerea on Geraldton Waxflower in South Africa". Plant Disease 86, nr 4 (kwiecień 2002): 440. http://dx.doi.org/10.1094/pdis.2002.86.4.440a.

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Geraldton waxflower (Chamelaucium uncinatum Schauer, family Myrtaceae), indigenous to western Australia, is cultivated commercially in South Africa as a cut-flower crop and exported to markets in the Northern Hemisphere. In September 2000, disease symptoms were observed on 4-year-old plants in a commercial orchard of C. uncinatum cv. Ofir in Philippe, in the Western Cape Province. The base of the petals and the calyxes of the waxflowers showed brown necrotic lesions. Eventually the calyx and all the petals turned brown, and the flowers shriveled and abscised. B. cinerea Pers.:Fr was consistently isolated from affected petal and calyx tissues. When placed in a moist chamber, conidia and mycelia formed on the surface of dead and infected tissue. Koch's postulates were confirmed by spraying flower stems of C. uncinatum cv. Ofir with a spore suspension (1 × 106 conidia per ml). Inoculated flower stems were placed in a bottle filled with water and enclosed in transparent plastic bags for 24 h at 21°C. Typical symptoms developed on the petals and calyx within 3 days after inoculation. B. cinerea was reisolated from affected tissues. Botrytis flower blight or gray mold, causing a flower petal disease, has been recorded on C. uncinatum in Australia (1), but this is the first record of Botrytis flower blight of C. uncinatum in South Africa. Because Geraldton waxflower is a major cut-flower crop grown for export, this disease can cause significant losses to the industry, especially under cool, wet growing conditions. Reference: (1) A. Tomas et al. Aust. Plant Pathol. 24:26, 1995.

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Сердюк, Ігор. "Вживання алкоголю в суспільстві Гетьманщини ХVІІІ ст. як маркер якості життя." Scientific Papers of the Vinnytsia Mykhailo Kotsyiubynskyi State Pedagogical University Series History, nr 46 (26.12.2023): 20–26. http://dx.doi.org/10.31652/2411-2143-2023-46-20-26.

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The purpose of the article is to study the culture of alcohol consumption in the Hetmanate of the 18th century as a marker of quality of life. The author analyzed the diaries of Cossack elders and the epistolary heritage of this period, singled out references to the use of alcoholic beverages, circumstances, cases of abuse. The research methodology is determined by the purpose and features of the main sources and, in addition to the application of general scientific methods (analysis, synthesis), involves the use of a microhistorical approach, elements of prosopography and social history. Since it is primarily about the analysis of diaries, the theoretical work of the French researcher Philippe Lejeune was applied, who examined the development of diaries from the "accounting of the past" to emotional notes. The scientific novelty of the research lies in the fact that alcohol consumption is not considered as a bad habit or a certain branch of the economy, but as a component of a person's leisure behavior, the realization of undesirable needs, which also determined the quality of life. It was concluded that from the point of view of traditional markers of quality, Ukrainian early modern society was quite homogeneous (life expectancy, mortality, diseases). Even the diet of the common people and the elite was often similar. But the consumption of alcoholic beverages was just one of those markers that at the everyday level testified to a higher or lower level of well-being. But their consumer culture was significantly different. Precisely from the point of view of alcohol consumption - frequency, volume, and its assortment, one can observe the difference in everyday life and its quality. Belonging to a higher social status and financial resources provided access to higher quality alcohol and higher quality of its consumption. At the same time, the Cossack elder of the Hetmanate had access to alcohol produced in different countries and corresponding to the lifestyle of the European nobility of that time. In this way, the "precious" people of old Ukraine were similar to the European establishment.

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Meloy, John L. "THOMAS PHILIPP AND ULRICH HAARMANN, ED., The Mamluks in Egyptian Politics and Society (Cambridge: Cambridge University Press, 1998). Pp. 320. $59.95 cloth." International Journal of Middle East Studies 32, nr 2 (maj 2000): 280–82. http://dx.doi.org/10.1017/s0020743800002324.

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In recent years, the field of Mamluk studies has seen what may well be an amount of published scholarship unparalleled in any field of Middle East studies. Less than a decade ago, the study of the Mamluk rulers of Egypt and Syria could hardly have been called a distinct field, and it was only about four decades ago that the period was given any systematic attention at all through the pioneering efforts of David Ayalon. However, Mamluk specialists now have their own journal, the Mamluk Studies Review, with three annual volumes in print and more on the way, as well as an extensive and ever-growing Web-based bibliography, both of which are published by the University of Chicago's Middle East Documentation Center. Mamluk specialists around the world have been engaged in this work, but it was initiated by Thomas Philipp and the late Ulrich Haarmann. In December 1994, these two scholars organized a conference on Mamluk studies in Bad Homburg, Germany, and eighteen of the papers presented at that symposium have been published as The Mamluks in Egyptian Politics and Society. The papers in this volume cover the period of the Mamluk sultanate in Egypt and Syria from 1250 to 1517, as well as the subsequent Ottoman period up to the rule of Muhammad Ali in the early 19th century. The richness of the sources for this period is evident in the diverse topics represented; papers dealing with political and social history are supplemented by studies in astronomy, religion, traditional culture, historiography, and urban geography. Indeed, the volume stands as a benchmark from which to view this rapidly growing field.

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Pribaz, Julian J. "Microsurgical Replantation of the Amputated Nose by Dennis C. Hammond, M.D., Carrie L. Bouwense, B.A., B.S., W. Tracy Hankins, M.D., Gwen S. Maxwell-Davis, M.D., Julie Furdyna, M.D., and Philippe A. Capraro, M.D." Plastic & Reconstructive Surgery 105, nr 6 (maj 2000): 2138–39. http://dx.doi.org/10.1097/00006534-200005000-00035.

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Deflers, Isabelle. "Philipp Melanchthon, Briefwechsel Band T 11: Texte 2866–3126 (1542). Bearbeitet von Matthias Dall’Asta, Heidi Hein, Simone Kurz und Christine Mundhenk. Frommann Holzboog, Stuttgart/Bad Cannstatt 2010, 414 S. ISBN 978-37-72-82534-7. €284. Philipp Melanchthon, Band T 12: Texte 3127–3420a (1543). Bearbeitet von Christine Mundhenk, Matthias Dall’Asta und Heidi Hein. Frommann Holzboog, Stuttgart/Bad Cannstatt 2011, 533 S. ISBN 978-37-72-82535-4. €284. Philipp Melanchthon, Band T 13: Texte 3421–3779 (1544). Bearbeitet von Matthias Dall’Asta, Heidi Hein und Christine Mundhenk. Frommann Holzboog, Stuttgart/Bad Cannstatt 2012. 631 S. ISBN 978-37-72-82574-3. €284." Church History and Religious Culture 93, nr 1 (1.01.2013): 127–31. http://dx.doi.org/10.1163/18712428-13930114.

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Jhaveri, Komal, Nadia Harbeck, Philippe Aftimos, Sung-Bae Kim, Xavier Pivot, Cristina Saura, Giuseppe Curigliano i in. "Abstract OT2-11-01: EMBER-3: A randomized phase 3 study of LY3484356, a novel, oral selective estrogen receptor degrader vs investigator’s choice of endocrine therapy of either fulvestrant or exemestane, in patients with estrogen receptor-positive, human epidermal growth factor receptor 2-negative, locally advanced or metastatic breast cancer previously treated with endocrine-based therapy". Cancer Research 82, nr 4_Supplement (15.02.2022): OT2–11–01—OT2–11–01. http://dx.doi.org/10.1158/1538-7445.sabcs21-ot2-11-01.

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Abstract Background: The estrogen receptor (ER) is the key therapeutic target for ER-positive (ER+), human epidermal growth factor receptor 2-negative (HER2-) breast cancer. Novel degraders of ER may overcome resistance to available endocrine therapy (ET) while providing consistent oral bioavailability and convenience of administration. LY3484356 is a novel, orally bioavailable selective estrogen receptor degrader (SERD) with pure antagonistic properties resulting in sustained inhibition of ER-dependent gene transcription and -cell growth. In the phase 1a/b EMBER trial, LY3484356 monotherapy demonstrated a favorable safety profile with pharmacokinetic (PK) exposures that exceeded fulvestrant. LY3484356 also showed single agent efficacy in patients with ER+, HER2- metastatic breast cancer (MBC), including in patients with baseline ESR1 mutations and fulvestrant- and/or CDK4/6 inhibitor- refractory disease1. Trial Design: EMBER-3 is a randomized, open-label, global phase 3 study comparing LY3484356 versus investigator’s choice of ET (fulvestrant or exemestane), in patients with ER+, HER2- locally advanced or MBC. Approximately 500 patients will be randomized 1:1 to receive LY3484356 (400 mg PO QD continuously in 28-day cycles) or investigator’s choice of ET (dosed per label). Males and pre-menopausal women will receive concomitant treatment with a GnRH agonist. Eligibility criteria: Eligible patients are adult males and females (pre- or post-menopausal) with ER+, HER2- locally advanced or MBC who have received prior treatment with an aromatase inhibitor, alone or in combination with a CDK4/6 inhibitor. No other prior therapy for advanced disease is permitted. Patients must have evaluable disease (measurable or non-measurable bone only). Study endpoints: The primary endpoint is investigator-assessed progression-free survival (PFS) per RECIST v1.1. Secondary endpoints include BIRC-assessed PFS, overall survival, objective response rate, duration of response, clinical benefit rate, safety and tolerability, PK and patient reported outcomes. Recruitment for the EMBER-3 study begins in Q3 2021. Reference: 1Jhaveri et al. J Clin Oncol 2021 39:15_suppl, 1050 Citation Format: Komal Jhaveri, Nadia Harbeck, Philippe Aftimos, Sung-Bae Kim, Xavier Pivot, Cristina Saura, Giuseppe Curigliano, Monica Casalnuovo, Xuejing Aimee Wang, Suzanne R.L. Young, Lillian Smyth, Joyce O'Shaughnessy. EMBER-3: A randomized phase 3 study of LY3484356, a novel, oral selective estrogen receptor degrader vs investigator’s choice of endocrine therapy of either fulvestrant or exemestane, in patients with estrogen receptor-positive, human epidermal growth factor receptor 2-negative, locally advanced or metastatic breast cancer previously treated with endocrine-based therapy [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr OT2-11-01.

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Wriedt, Markus. "Philipp Melanchthon. Melancthons Briefwechsel. Vol. 8. Texte 1980–2335 (1538–1539). Eds. Christine Mundhenk, Heidi Hein, and Judith Steiniger. Stuttgart-Bad Cannstatt: Frommann-Holzboog, 2007. 701 pp. index. €232. ISBN: 978-3-7728-2440-1." Renaissance Quarterly 61, nr 2 (2008): 574–76. http://dx.doi.org/10.1353/ren.0.0107.

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Castellani, Pablo, Clement Nicollet, Eric Quarez, Olivier Joubert i Annie Le Gal La Salle. "Synthesis of Yttrium Doped Barium Zirconate/Cerate Electrolyte Materials and Densification Using Conventional and Cold-Sintering Processes". ECS Meeting Abstracts MA2022-02, nr 49 (9.10.2022): 1945. http://dx.doi.org/10.1149/ma2022-02491945mtgabs.

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Compared to high temperature SOEC usually based on Yttrium stabilized Zirconia electrolytes, intermediate temperature PCEC allows the production of water free hydrogen and a better chemical stability. Proton conducting perovskite specific materials, such as Barium Indates1, Zirconate or Cerates2 are nearly commercial electrolytes for such devices. This study focuses on the synthesis the characterization and the densification of the BaZr1-xCexY0.1O3- δ 3 powder. At intermediate temperature and under humid atmosphere, hydration process allows diffusion of protonic charges. Such electrolyte material combines a low thermal expansion coefficient and a high protonic conductivity. Two specific stoichiometry’s have been studied, Cerium rich BaZr 0.3 Ce 0.6 Y0.1O3- δ (BZCY361) and Zirconium rich BaZr 0.7 Ce 0.2 Y0.1O3- δ (BZCY721). BZCY361 shows at 550°C, a conductivity level of 2.10- 2 S.cm- 1. However, despite its high protonic conductivity, the cerium rich phase is not stable at high temperature and is torn apart in presence of carbon dioxide. BaZr1-xCexY0.1O3- δ powder has been synthetized by combustion reaction based on nitrate precursors and glycine as organic complexing/fuel agent. The fuel/oxidizer (nitrates) ratio, which is a key parameter4, has been optimized in order to obtain the best purity and crystallinity. The powder is then milled and calcined. The single-phase electrolyte powder is conventionally shaped into pellets and densified A minimal temperature of 1600°C is necessary to obtained a density of 90-95%. In order to reduce the sintering temperature, an intermediate sintering step called "Cold Sintering Process"5 (CSP) has been investigated. In this technic, derived from the hydrothermal method, BCZY powder mixed with a small volume of liquid phase (3-30 wt%) is simultaneously pressed (at 50 to 500 MPa) and heated during a short time period (1-60 min) at low temperatures (100-200°C), leading to dense pellets. In regards to design a complete cell based on this electrolyte, EIS has been performed under hydrogen and air atmosphere. The electrochemical measurements of the samples provided by the different protocols and stoichiometry’s have been compared in order to determine the impact of the CSP and stoichiometry parameters on the ionic conductivity of the material. Acknowledgment: This study, included in the PhD of P. Castellani, was made possible with support from the Franco German ANR-BMBF project (Grant No. ANR-19-ENER-0003-12 [1] Quarez, Eric, Samuel Noirault, Annie Le Gal La Salle, Philippe Stevens, et Olivier Joubert. « Evaluation of Ba2(In0.8Ti0.2)2O5.2−n(OH)2n as a Potential Electrolyte Material for Proton-Conducting Solid Oxide Fuel Cell ». Journal of Power Sources 195 (15), 4923-27 (2010) [2] Thabet, K., Le Gal La Salle, A., Quarez, E., and Joubert, O. “Protonic-Based Ceramics for Fuel Cells and Electrolyzers,” Solid Oxide-Based Electrochemical Devices, Elsevier, pp. 91–122 (2020) [3] Thabet, K., Devisse, M., Quarez, E., Joubert, O., and Le Gal La Salle, A. “Influence of the Autocombustion Synthesis Conditions and the Calcination Temperature on the Microstructure and Electrochemical Properties of BaCe0.8Zr0.1Y0.1O3− δ Electrolyte Material,” Solid State Ionics, 325, pp. 48–56, (2018) [4] Varma, A., Mukasyan, A. S., Rogachev, A. S., and Manukyan, K. V., “Solution Combustion Synthesis of Nanoscale Materials,” Chem. Rev., 116(23), pp. 14493–14586 (2016) [5] Guo, H., Baker, A., Guo, J., and Randall, C. A., “Cold Sintering Process: A Novel Technique for Low‐Temperature Ceramic Processing of Ferroelectrics,” J. Am. Ceram. Soc., 99(11), pp. 3489–3507 (2016) Figure 1

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Wang, Yanchao, Fredrick D. Gootkind, Florent Peyraud, Jean-Philippe Guégan, Antoine Italiano, G. Travis Clifton, Laura A. Dillon i Xinwei Sher. "Abstract 7392: Machine learning-based identification of H&E-derived morphologic features associated with CD8+ T cell immune exclusion". Cancer Research 84, nr 6_Supplement (22.03.2024): 7392. http://dx.doi.org/10.1158/1538-7445.am2024-7392.

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Abstract Background: Immune exclusion is characterized by a predominance of CD8+ T cells in the stroma of the tumor microenvironment (TME) which are not in contact with tumor cells. Immune exclusion is a significant obstacle to effective cancer immunotherapy and reversing it has emerged as a new therapeutic opportunity. However, the objective assessment of immune exclusion remains a challenge due to the complexity of the TME and the need for immunostaining to quantify CD8+ cells in tumor and stroma. While artificial intelligence (AI) models applied to H&E images can quantify spatial tissue and cell features at scale, they are unable to identify the molecular subtypes of cells. Here we describe the development of a machine learning model that classifies tumors by their CD8-defined immune phenotypes using features extracted from H&E whole slide images alone. Methods: Al-powered TME models (PathAI PathExplore™) were deployed on H&E images from 39 non-small lung cancer (NSCLC) and triple-negative breast cancer (TNBC) samples. CD8-based assessment of immune phenotypes was done using an adjacent section. 115 H&E-derived features from each of the 25 tumor samples (12 NSCLC, 13 TNBC) classified as immune excluded and 7 tumor samples (3 NSCLC, 4 TNBC) classified as immune infiltrated were used as input into a feature selection process to identify the subset of H&E features predictive of immune phenotype. The feature selection process was driven by an ensemble L1 norm support vector machine (Ens-L1-SVM) model containing 500 L1-SVM base models each trained by 80% of the data. The degree of immune exclusion was determined in the feature space by the distance to the separation hyperplane defined by the model. Out-of-bag error estimation was employed on the remaining 20% of data from each base model to assess model performance. Results: The Ens-L1-SVM model identified 6 H&E features predictive of CD8-defined immune phenotypes, including the density ratio of lymphocytes to macrophages in the cancer epithelium, the density of fibroblasts, and the spatial distributions of cancer cells, macrophages, and lymphocytes. Immune phenotypes were classified by the Ens-L1-SVM model with an estimated accuracy of 97%. Additionally, all selected features and their direction of association aligned with prior knowledge of the mechanisms or manifestations of immune exclusion or infiltration in the TME. Conclusion: This work illustrated that morphologic features derived from H&E images using AI-powered models can be effective predictors of CD8-defined immune exclusion, providing an option for patient stratification by immune phenotype using widely-available H&E images. While the Ens-L1-SVM model showed robust performance on a small number of samples and is expected to have good generalizability due to the linear nature of the model, additional validation across diverse datasets and various tumor indications is needed. Citation Format: Yanchao Wang, Fredrick D. Gootkind, Florent Peyraud, Jean-Philippe Guégan, Antoine Italiano, G. Travis Clifton, Laura A. Dillon, Xinwei Sher. Machine learning-based identification of H&E-derived morphologic features associated with CD8+ T cell immune exclusion [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 7392.

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Rombouts, Frederik J., Lento William, Ingrid Velter, Ann Vos, Aldo Peschiulli, Reuillon Tristan, Maria Dominguez Blanco i in. "Abstract 2133: In pursuit of MCL-1 inhibitors with improved therapeutic window for the treatment of hematological malignancies: Discovery of JNJ-4355". Cancer Research 82, nr 12_Supplement (15.06.2022): 2133. http://dx.doi.org/10.1158/1538-7445.am2022-2133.

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Abstract Appropriate control of cell death is a fundamental biological process which is frequently dysregulated during tumor development and therapeutic resistance. Apoptosis is a form of regulated cell death initiated by either the extracellular environment (extrinsic) or following internal cellular damage (intrinsic). It is controlled by the BCL-2 family which includes anti-apoptotic regulators like BCL-2, BCL-XL and MCL-1 that bind and sequester various pro-apoptotic BH3-only proteins (BIM, BAD, BID, NOXA, PUMA, etc.), and the pro-apoptotic effectors (BAK, BAX, etc.) responsible for mitochondrial pore formation and MOMP (mitochondrial outer membrane permeabilization). MOMP results in intermembrane space protein release, leading to caspase activation in an irreversible path to programmed cell death. Of the anti-apoptotic regulators, MCL-1 is one of the most frequently and highly amplified genes in human cancers such as myeloid leukemia making it a compelling therapeutic target. Since BCL-2 proteins interact through protein-protein interactions, they have long been elusive targets. The success of selective BCL-2 protein inhibitor Venetoclax in the treatment of various hematological cancers, however spurred interest in MCL-1 as an oncology target. Using structure-based drug design, major breakthroughs were made in the development of MCL-1 inhibitors, with several candidates entering clinical studies in the past five years. JNJ-4355, a highly potent 1,4-indolyl macrocycle (MCL-1 Ki = 18 pM, Cell (MOLP8) AC50 = 8.7 nM) was optimized to address shortcomings from first generation MCL-1 inhibitors: it has improved physicochemical properties (CHI LogD7.4 = 2.35, EPSA = 151 Å2), resulting in greatly improved equilibrium solubility (3.14 mM in buffer pH 7) and reduced protein binding (99.93%). JNJ-4355 showed promising in vitro potency data in cancer cell lines and AML patient-derived samples (cell killing AC50 0.29-75 nM in 25/27 evaluable samples). In vivo MCL-1:BAK complex disruption was confirmed in a mouse MOLM13 (AML) xenograft. Efficacy was demonstrated in a mouse MOLP8 (multiple myeloma) xenograft resulting in complete tumor regression after a single IV dose of JNJ-4355. Citation Format: Frederik J. Rombouts, Lento William, Ingrid Velter, Ann Vos, Aldo Peschiulli, Reuillon Tristan, Maria Dominguez Blanco, Matthieu Jouffroy, Lisa McQueen, Helena Steyvers, Mariette Bekkers, Cristina Altrocchi, Beth Pietrak, Seong Joo Koo, Lawrence Szewczuk, David Walker, Kathryn Packman, Ruud Bueters, Petra Vinken, Amy Johnson, Ricardo Attar, Ulrike Philippar. In pursuit of MCL-1 inhibitors with improved therapeutic window for the treatment of hematological malignancies: Discovery of JNJ-4355 [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 2133.

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Schulte-Wülwer, Ulrich. "Deutsch-dänische Kunstbeziehungen 1820 bis 1920". Nordelbingen: Beiträge zur Geschichte der Kunst und Kultur, Literatur und Musik in Schleswig-Holstein, nr 89 (grudzień 2023): 115–68. http://dx.doi.org/10.38072/2941-3362/p6.

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In the last decade of the 18th century, the Danish state experienced a period of prosperity, which was characterized by a German-Danish cultural transfer in all intellectual fields. The first clouds were cast by the rise of an artistic self-confidence. Asmus Jacob Carstens from Schleswig and Ernst Meyer from Altona, who felt disadvantaged in the awarding of medals and protested vehemently, were expelled from the art academy in Copenhagen in 1781 and 1821. Nevertheless, the Copenhagen Art Academy had a strong attraction for numerous artists from northern Germany. In this respect, Caspar David Friedrich, Philipp Otto Runge and Georg Friedrich Kersting are primarily worthy of mention. The Danish sculptor Bertel Thorvaldsen was a strong link between the Germans and Scandinavians living in Rome throughout his life. The first cracks in the good bilateral relationship came with the strengthening of the national liberal movements. In 1842, the influential teacher at the Copenhagen Art Academy, N.L. Høyen, drew up a program aimed at repressing influences from abroad, especially from Germany. Not all artists heeded Høyens call for a return to national themes of history, folk life, and nature, so that two groups confronted each other in Denmark: the nationalists and the Europeans. With the German-Danish War of 1848/51 there was a rift, and with the war of 1864 the final break. Only after twenty years did the academies of Copenhagen and Berlin resume contact. From 1883 onwards, there were reciprocal visits, which led to Danish artists once again taking part in representative exhibitions in Berlin or Munich. Conversely, however, German artists were denied participation in exhibitions in Copenhagen, an exception being the International Art Exhibition on the inauguration of the Ny Carlsberg Glyptotek in Copenhagen in 1897. A spirit freed from all academic constraints also emanated from the artist colonies in Europe. In particular, the works of the Skagen painters were enthusiastically celebrated at exhibitions in Munich and Berlin, which led to some German painters traveling to the Danish artists' colony, where they were received without prejudice. However, at no time was there a balance in the official acceptance and appreciation of the art of the respective neighbouring country. While painters such as Michael Ancher and Peder Severin Krøyer sold works to renowned collectors and museums in Germany, no Danish Museum acquired the work of a German artist during the period under study. The Berlin painter Walter Leistikow, who was married to a Danish woman, worked hard to stimulate a German-Danish art transfer and succeeded in getting the leading Danish gallery owner Valdemar Kleis to offer German painters the opportunity to exhibit in Copenhagen for the first time in 1894, most of whom belonged to the group Die XI, a precursor of the Berlin Secession. The appreciation of the Skagen painters was replaced at the turn of the century by admiration works by F.J. Willumsen and Vilhelm Hammershøj. Hammershøj filled a room of his own at the Great Berlin Art Exhibition in 1900 with 14 works, and the Schulte Gallery in Berli While German admiration for Danish art peaked between 1890 and 1900, people in Denmark continued to look past the German art scene. This was also experienced by the artists' group Die Brücke, which sought foreign members soon after its founding. When Kleis presented works by the Brücke artists in Copenhagen in 1908, they too received only negative reviews. In March 1910, the time seemed ripe for a change of mood. The Berlin gallery owner Herwarth Walden strove to make his Sturm-Galerie a rallying point for the European modernist art movements. In July 1912, he rented the exhibition building of the secessionist group Den Frie in Copenhagen and held an exhibition of Italian Futurists there. When Walden was celebrated by the Danish press as a cosmopolitan who had brought modernism to Copenhagen, he showed works by the French Henri le Fauconier and Raoul Dufy, as well as the painters Marianne von Werefkin and Gabriele Münter, but the tenor of the press was again dominated by anti-German resentment. After the outbreak of World War I, Walden allowed himself to be abused by the German propaganda department of the German Secret and Intelligence Service, which strove to correct the image of Germans abroad as cultural barbarians. Walden showed works by Kandinsky, Klee, Kokoschka, Marc, and again Gabriele Münter at the Copenhagen artists’ cabaret Edderkoppen in the fall of 1917. He also planned an exhibition of Danish avant-garde in his Sturm Gallery in Berlin, but the artists had become suspicious in the face of German propaganda, which was celebrating a last military success. The exhibition was canceled. This did not prevent Walden from organizing an exhibition at Kleis’ art shop in Copenhagen shortly before the end of the war, under the guise of internationalism. This was Walden's largest and most ambitious project in Scandinavia. Of the 133 works exhibited, almost half came from Germany. The attempt to convince the Danes of the excellence of German art failed miserably, because the basic conviction was still: Everything that comes from Germany is bad. The opening took place on November 28 and ended on December 16, 1918, by which time the war was already over.

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