Gotowe bibliografie tematyczne / Phi01

Spis treści

  1. Artykuły w czasopismach
  2. Rozprawy doktorskie
  3. Książki
  4. Części książek
  5. Streszczenia konferencji
  6. Raporty organizacyjne

Gotowa bibliografia na temat „Phi01”

Autor: Grafiati
Data publikacji: 29 lipca 2024
Data aktualizacji: 30 lipca 2024

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Artykuły w czasopismach na temat "Phi01"

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Bocianowski, Jan, Kamila Nowosad, Barbara Wróbel i Piotr Szulc. "Identification of Associations between SSR Markers and Quantitative Traits of Maize (Zea mays L.)". Agronomy 11, nr 1 (19.01.2021): 182. http://dx.doi.org/10.3390/agronomy11010182.

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Microsatellite or simple sequence repeat (SSR) markers have wide applicability for genetic analysis in crop plant improvement strategies. Marker-assisted selection is an important tool for plant breeders to increase the efficiency of a breeding process, especially for multigenic traits, highly influenced by the environment. In this paper, the relationships between SSR markers and 26 quantitative traits of hybrid maize varieties (Zea mays L.) were analyzed. Association analyses were performed based on 30 SSR primers in a set of thirteen hybrid maize varieties. A total of 112 SSR markers were detected in these genotypes. The number of alleles per locus ranged from 1 to 17, with the average number of alleles per locus equal to 3.7. The number of molecular markers associated with observed traits ranged from 1 (for the number of kernels in row, ears weight and fresh weight of one plant) to 14 (for damage of maize caused by P. nubilalis) in 2016 as well as from 1 (for soil plant analysis development—SPAD, the number of grains in ear and fresh weight of one plant) to 12 (for carotenoids content) in 2017. The sum of statistically significant associations between SSR markers and at least one trait was equal to one hundred sixty in 2016 as well as one hundred twenty-five in 2017. Marker trait associations (MTAs) were found on the basis of regression analysis. The proportion of the total phenotypic variances of individual traits explained by the marker ranged from 24.4% to 77.7% in the first year of study and from 24.3% to 77.9% in 2017. Twenty-two SSR markers performed a significant effect on at least one tested trait in both years of experiment. The three markers (phi021/4, phi036/3, and phi061/2) can be a good tool in marker-assisted selection because they allow simultaneous selection for multiple traits in both years of study, such as the number of kernels in row and the number of grains in ear (phi021/4), the number of plant after germination, the number of plants before harvest, and the number of ears (phi036/3), as well as moisture of grain and length of ears (phi061/2).
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Магомед-Касумов, Магомедрасул Грозбекович, Magomedrasul Grozbekovich Magomed-Kasumov, Таджидин Нурмагомедович Шах-Эмиров i Tadgidin Nurmagomedovich Shakh-Emirov. "О представлении соболевских систем, ортогональных относительно скалярного произведения с одной дискретной точкой". Matematicheskie Zametki 111, nr 4 (2022): 561–70. http://dx.doi.org/10.4213/mzm13321.

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Получено представление систем функций $\Phi_1$, ортогональных относительно скалярного произведения типа Соболева с одной дискретной точкой, в терминах функций систем, ортогональных в $L^2$. Исследованы вопросы полноты системы $\Phi_1$. Изучены некоторые свойства систем функций, полученных дифференцированием системы $\Phi_1$. Библиография: 3 названия.
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Podcheko, Alexey, Paul Northcott, George Bikopoulos, Andrew Lee, Swaroop R. Bommareddi, Jake A. Kushner, Janet Farhang-Fallah i Maria Rozakis-Adcock. "Identification of a WD40 Repeat-Containing Isoform of PHIP as a Novel Regulator of β-Cell Growth and Survival". Molecular and Cellular Biology 27, nr 18 (16.07.2007): 6484–96. http://dx.doi.org/10.1128/mcb.02409-06.

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ABSTRACT The pleckstrin homology domain-interacting protein (PHIP) was originally identified as a 902-amino-acid (aa) protein that regulates insulin receptor-stimulated GLUT4 translocation in skeletal-muscle cells. Immunoblotting and immunohistological analyses of pancreatic β-cells reveal prominent expression of a 206-kDa PHIP isoform restricted to the nucleus. Herein, we report the cloning of this larger, 1,821-aa isoform of PHIP (PHIP1), which represents a novel WD40 repeat-containing protein. We demonstrate that PHIP1 overexpression stimulates insulin-like growth factor 1-dependent and -independent proliferation of β-cells, an event which correlates with transcriptional upregulation of the cyclin D2 promoter and the accumulation of cyclin D2 protein. RNA interference knockdown of PHIP1 in INS-1 cells abrogates insulin receptor substrate 2 (IRS2)-mediated DNA synthesis, providing for a specific role for PHIP1 in the enhancement of IRS2-dependent signaling responses leading to β-cell growth. Finally, we provide evidence that PHIP1 overexpression blocks free fatty acid-induced apoptosis in INS-1 cells, which is accompanied by marked activation of phosphoprotein kinase B (PKB)/AKT and the concomitant inhibition of caspase-9 and caspase-3 cleavage. Our finding that the restorative effect of PHIP1 on β-cell lipotoxicity can be attenuated by the overexpression of dominant-negative PKB suggests a key role for PKB in PHIP1-mediated cytoprotection. Taken together, these findings provide strong support for PHIP1 as a novel positive regulator of β-cell function. We suggest that PHIP1 may be involved in the induction of long-term gene expression programs to promote β-cell mitogenesis and survival.
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Chen, Yibao, Guanghao Guo, Erchao Sun, Jiaoyang Song, Lan Yang, Lili Zhu, Wan Liang i in. "Isolation of a T7-Like Lytic Pasteurella Bacteriophage vB_PmuP_PHB01 and Its Potential Use in Therapy against Pasteurella multocida Infections". Viruses 11, nr 1 (21.01.2019): 86. http://dx.doi.org/10.3390/v11010086.

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A lytic bacteriophage PHB01 specific for Pasteurella multocida type D was isolated from the sewage water collected from a pig farm. This phage had the typical morphology of the family Podoviridae, order Caudovirales, presenting an isometric polyhedral head and a short noncontractile tail. PHB01 was able to infect most of the non-toxigenic P. multocida type D strains tested, but not toxigenic type D strains and those belonging to other capsular types. Phage PHB01, the first lytic phage specific for P. multocida type D sequenced thus far, presents a 37,287-bp double-stranded DNA genome with a 223-bp terminal redundancy. The PHB01 genome showed the highest homology with that of PHB02, a lytic phage specific for P. multocida type A. Phylogenetic analysis showed that PHB01 and PHB02 were composed of a genus that was close to the T7-virus genus. In vivo tests using mouse models showed that the administration of PHB01 was safe to the mice and had a good effect on treating the mice infected with different P. multocida type D strains including virulent strain HN05. These findings suggest that PHB01 has a potential use in therapy against infections caused by P. multocida type D.
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Das, Avijit, Sukhendu Mandal, Vijay Hemmadi, Vivek Ratre i Malabika Biswas. "Studies on the gene regulation involved in the lytic–lysogenic switch in Staphylococcus aureus temperate bacteriophage Phi11". Journal of Biochemistry 168, nr 6 (23.07.2020): 659–68. http://dx.doi.org/10.1093/jb/mvaa080.

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Abstract Antirepressor proteins of bacteriophages are chiefly involved in interfering with the function of the repressor protein and forcing the bacteriophage to adopt the lytic cycle. The genome of Staphylococcus aureus phage, Phi11 has already been sequenced; from the genome sequence, we amplified gp07 gene and analysed its involvement in the developmental pathway of Phi11. Our results indicate that Gp07 functions as a novel antirepressor and regulates the developmental pathway of Phi11 by enhancing the binding of the Cro repressor protein to its cognate operator. We also report our finding that the CI repressor protein of Phi11 binds to the putative operator of Gp07 and regulates its expression. We further report that S.aureus transcriptional repressor LexA and coprotease RecA play a crucial role in the lytic–lysogenic switching in Phi11. We also identified that the N-terminal domain (Bro-N) of Gp07 is actually responsible for enhancing the binding of Cro repressor to its cognate operator. Our results suggest that Phi11 prophage induction is different from other bacteriophages. This study furnishes a first-hand report regarding the regulation involved in the developmental pathway of Phi11.
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Saini, Ekta, Pradeep Kumar Sheokand, Vaibhav Sharma, Prakhar Agrawal, Inderjeet Kaur, Shailja Singh, Asif Mohmmed i Pawan Malhotra. "Plasmodium falciparum PhIL1-associated complex plays an essential role in merozoite reorientation and invasion of host erythrocytes". PLOS Pathogens 17, nr 7 (29.07.2021): e1009750. http://dx.doi.org/10.1371/journal.ppat.1009750.

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The human malaria parasite, Plasmodium falciparum possesses unique gliding machinery referred to as the glideosome that powers its entry into the insect and vertebrate hosts. Several parasite proteins including Photosensitized INA-labelled protein 1 (PhIL1) have been shown to associate with glideosome machinery. Here we describe a novel PhIL1 associated protein complex that co-exists with the glideosome motor complex in the inner membrane complex of the merozoite. Using an experimental genetics approach, we characterized the role(s) of three proteins associated with PhIL1: a glideosome associated protein- PfGAPM2, an IMC structural protein- PfALV5, and an uncharacterized protein—referred here as PfPhIP (PhIL1 Interacting Protein). Parasites lacking PfPhIP or PfGAPM2 were unable to invade host RBCs. Additionally, the downregulation of PfPhIP resulted in significant defects in merozoite segmentation. Furthermore, the PfPhIP and PfGAPM2 depleted parasites showed abrogation of reorientation/gliding. However, initial attachment with host RBCs was not affected in these parasites. Together, the data presented here show that proteins of the PhIL1-associated complex play an important role in the orientation of P. falciparum merozoites following initial attachment, which is crucial for the formation of a tight junction and hence invasion of host erythrocytes.
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Jantip, Suesat, i Potjanart Suwanruji. "Preparation and Properties of Microcrystalline Cellulose from Corn Residues". Advanced Materials Research 332-334 (wrzesień 2011): 1781–84. http://dx.doi.org/10.4028/www.scientific.net/amr.332-334.1781.

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The agricultural wastes from harvesting corn, viz. corn husks and corn cobs were used as raw materials for the preparation of microcrystalline cellulose. From chemical composition analysis, holocellulose, -cellulose, hemicellulose, extractive and ash contents found in the corn husk were higher than those in the corn cob except for lignin. The study found that these corn residues could potentially be used for microcrystalline cellulose preparation. The properties of the microcrystalline cellulose obtained from these corn residues were examined in comparison with the commercial microcrystalline cellulose, Avicel PH101. Their crystal feature was in cellulose I form which showed the crystal reflections at 2s around 15 o, 17 o and 22o, being the same as that of Avicel PH101. Whilst their crystallinity was lower and the crystal size was smaller than Avicel PH101. The crystal size of the microcrystalline cellulose from the corn residues was around 3 nm whereas that of Avicel PH101 was about 4 nm. In addition, the thermal stability of the prepared microcrystalline cellulose was slightly lower than that of Avicel PH101. Corn husks provided more thermally stable microcrystalline cellulose than corn cobs.
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Peleshenko, B. I., i T. N. Semirenko. "On interpolation of operators of weak type $$$(\phi_0, \psi_0, \phi_1, \psi_1)$$$ in Lorentz spaces in borderline cases". Dnipro University Mathematics Bulletin 26, nr 1 (25.06.2018): 68. http://dx.doi.org/10.15421/241809.

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The quaslinear operators of weak type $$$(\phi_0, \psi_0, \phi_1, \psi_1)$$$, analogs of the Calderon, Bennett operators in the case of concave and convex functions $$$\phi_0(t)$$$, $$$\psi_0(t)$$$, $$$\phi_1(t)$$$, $$$\psi_1(t)$$$ are considered. The theorems of interpolation of these operators from the Lorentz space $$$\Lambda_{\psi, b}(\mathbb{R}^n)$$$ into the space $$$\Lambda_{\psi, a}(\mathbb{R}^n)$$$ in cases when $$$0 < b \leqslant a \leqslant 1$$$ and relation of function $$$\phi^{\frac{1}{b}}(t)$$$ to one of functions $$$\phi_1(t)$$$, $$$\phi_2(t)$$$ is slowly varying function are proved.
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Dyall-Smith, Mike, Peter Palm, Gerhard Wanner, Angela Witte, Dieter Oesterhelt i Friedhelm Pfeiffer. "Halobacterium salinarum virus ChaoS9, a Novel Halovirus Related to PhiH1 and PhiCh1". Genes 10, nr 3 (1.03.2019): 194. http://dx.doi.org/10.3390/genes10030194.

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The unexpected lysis of a large culture of Halobacterium salinarum strain S9 was found to be caused by a novel myovirus, designated ChaoS9. Virus purification from the culture lysate revealed a homogeneous population of caudovirus-like particles. The viral genome is linear, dsDNA that is partially redundant and circularly permuted, has a unit length of 55,145 nt, a G + C% of 65.3, and has 85 predicted coding sequences (CDS) and one tRNA (Arg) gene. The left arm of the genome (0–28 kbp) encodes proteins similar in sequence to those from known caudoviruses and was most similar to myohaloviruses phiCh1 (host: Natrialba magadii) and phiH1 (host: Hbt. salinarum). It carries a tail-fiber gene module similar to the invertible modules present in phiH1 and phiCh1. However, while the tail genes of ChaoS9 were similar to those of phiCh1 and phiH1, the Mcp of ChaoS9 was most similar (36% aa identity) to that of Haloarcula hispanica tailed virus 1 (HHTV-1). Provirus elements related to ChaoS9 showed most similarity to tail/assembly proteins but varied in their similarity with head/assembly proteins. The right arm (29–55 kbp) of ChaoS9 encoded proteins involved in DNA replication (ParA, RepH, and Orc1) but the other proteins showed little similarity to those from phiH1, phiCh1, or provirus elements, and most of them could not be assigned a function. ChaoS9 is probably best classified within the genus Myohalovirus, as it shares many characteristics with phiH1 (and phiCh1), including many similar proteins. However, the head/assembly gene region appears to have undergone a recombination event, and the inferred proteins are different to those of phiH1 and phiCh1, including the major capsid protein. This makes the taxonomic classification of ChaoS9 more ambiguous. We also report a revised genome sequence and annotation of Natrialba virus phiCh1.
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Leveles, Ibolya, Veronika Kadar, Imre Zagyva, Abris Bendes, Gergely Rona, Kinga Nyiri, Veronika Nemeth, Judit Toth i Beata G. Vertessy. "Structural analysis of Phi11 staphylococcal dUTPase". Acta Crystallographica Section A Foundations of Crystallography 69, a1 (25.08.2013): s354. http://dx.doi.org/10.1107/s0108767313096943.

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Rozprawy doktorskie na temat "Phi01"

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Chinyemba, Patience. "Use of Aloe vera and Aloe marlothii materials as excipients in beads produced by extrusion-spheronization / Patience Chinyemba". Thesis, North-West University, 2012. http://hdl.handle.net/10394/9641.

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Microcrystalline cellulose (MCC) is the most commonly used excipient in the manufacture of spherical particles or beads by extrusion spheronisation. However, the use of MCC in beads has its limitations such as prolonged release of drugs due to lack of disintegration. The aim of this study was to determine if Aloe vera and Aloe marlothii leaf materials can be used as excipients in the production of beads prepared by extrusion spheronisation. A 23 full factorial design was employed for optimisation and to explore the effects of the concentration of MCC, polyvinylpyrrolidone and aloe materials on the sphericity and release rate of ketoprofen. Scanning electron microscopy revealed more porous beads when aloe materials were included in the bead formulations compared to the formulation with MMC alone. The bead formulations containing aloe materials exhibited faster drug release compared to that of the formulation containing MCC alone. Dissolution data of the optimised formulations were analysed in terms of mean dissolution time (MDT) as well as fit factors (f1 and f2). The optimised bead formulations had dissolution profiles comparable to that of the formulation containing MCC alone at pH 1.2 and 4.5 (f2 values > 70), but less comparable to the reference at pH 6.8 (50 < f2< 65) due to faster drug release. Aloe vera and Aloe marlothii leaf materials can be used successfully together with MCC in the production of beads by extrusion spheronisation.
Thesis (MSc (Pharmaceutics))--North-West University, Potchefstroom Campus, 2013.
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Lee, Chan Mi. "Investigating the Role of PHIP1 in Breast Cancer". Thesis, 2012. http://hdl.handle.net/1807/35154.

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PHIP1 is a novel downstream transcriptional co-regulator of insulin-like growth factor-I receptor (IGF-IR), a tyrosine kinase receptor that is often elevated and autophosphorylated in breast cancer. In this study, I show that PHIP1 is upregulated in MCF10A cells stably overexpressing IGF-IR signaling components and that knock-down of PHIP1 significantly inhibits breast cancer cell proliferation by inducing transcriptional upregulation of p21 and downregulation of cyclin D2. I also show that stable overexpression of PHIP1 in MCF10A cells can lead to its proteasomal degradation. Together, our data indicate that PHIP1 is implicated in breast cancer cell growth and suggest a number of avenues that await exciting discovery.
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Książki na temat "Phi01"

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PHotoEspaña (Festival). (4th 2000 Madrid, Spain). PHE01: PHotoEspaña 2001, Festival Internacional de Fotografía, Madrid 13 de junio- 15 de julio. Madrid: La Fábrica, 2001.

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Talal Asad; Wendy Brown; Judith Butler; Saba Mahmood. Is Critique Secular? Fordham University Press, 2013.

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PHI201: Thinking It Through 2e. Soomo Learning, 2022.

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PHI201: Thinking It Through 2e. Soomo Learning, 2022.

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Phe01: Photoespa~na 2001, Festival Internacional de Fotografia, Madrid 13 de Junio- 15 de Julio. Fabrica, 2001.

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Części książek na temat "Phi01"

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Buekens, Filip. "Philosophy of action". W Handbook of Pragmatics, 1056–60. Amsterdam: John Benjamins Publishing Company, 2022. http://dx.doi.org/10.1075/hop.m2.phi1.

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Arrojo, Rosemary. "Philosophy and translation". W Handbook of Translation Studies, 247–51. Amsterdam: John Benjamins Publishing Company, 2010. http://dx.doi.org/10.1075/hts.1.phi1.

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Jackson, Blair. "Introduction to We Want Phil1 An Interview. and In Phil We Trust: A Conversation". W The Grateful Dead Reader, 239–47. Oxford University PressNew York, NY, 2000. http://dx.doi.org/10.1093/oso/9780195124705.003.0031.

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Abstract It seemed somehow appropriate that on the morning of the day I was to interview Phil Lesh. I was jolted from a sound I sleep at 6:54 a.m. by a rumbling 5.4 magnitude earthquake. Talk about a rattling bass sound-Phil’s got a ways to go before he matches that one! To make matters weirder. it was also the 84th anniversary of San Francisco’s ‘06 quake: I instantly thought of Phil’s famous “Earthquake Space during a Hartford Civic show April 18.1982. the 76th anniversary: “SAN FRANCISCO IN RUINS!!”-Bwonnnnnnnngg!!-thuddddd-thudthud!! ”._’-: Actually. through the years there have been times during space at a show when I’ve been sitting there with my eyes dosed.and Phil’s bass emitted such a ground-shaking low note that I honestly wondered if the ceiling above might start to crumble. Crushed at a Grateful Dead show-what a way to go! These fantasies are rare. however. and more often I associate Phil’s bass sound with less threatening natural forces: I keep thinking of that line in crazy Fingers”-”Peals of fragile thunder. keeping time.”
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Streszczenia konferencji na temat "Phi01"

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Ibragimov, A., An Baymiev i O. Lastochkina. "Development of fluorescent protein-marked strains of Bacillus subtilis". W 2nd International Scientific Conference "Plants and Microbes: the Future of Biotechnology". PLAMIC2020 Organizing committee, 2020. http://dx.doi.org/10.28983/plamic2020.104.

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Moore, Amanda R., Lisa McGinnis i Shiva Malek. "Abstract PHA01: Modeling the tissue-specific oncogenesis of mutant RAS". W Abstracts: AACR Special Conference on the Evolving Landscape of Cancer Modeling; March 2-5, 2020; San Diego, CA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.camodels2020-pha01.

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MacBride, Charles, i Robert Arlt. "PH01:BRK: Potentials of Teaching Building Science through Design-Build". W 110th ACSA Annual Meeting Paper Proceedings. ACSA Press, 2022. http://dx.doi.org/10.35483/acsa.am.110.5.

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The construction of a certified passive house in a rural, red state signals the successful completion of a case-study project that has had far-reaching effects beyond initial expectations. Instituting passive house principles into the curriculum of a newly established professional degree program was highlighted by the design, construction, certification, sale and monitoring of this single-family home. And while the house is the most visible manifestation, the ongoing influence of the larger initiative may prove to be its most important legacy. This includes a solidifying curriculum that teaches passive strategies, environmental stewardship and professional responsibility, and further establishes the department’s role in community design, leading by example in an underserved region. The cycle of certified houses, established by PH01:BRK, now seeks to enter a self-sustaining mode of developing projects. The PHIUS certified PH01:BRK serves as a model to successor projects that hone technical, budgetary and curricular constraints while continuing the momentum established by the first house. This paper describes the initiative within a pedagogical context, as a forerunner of sustainable building within the regional building industry, and as a political marker in a state that rejects regulation and often the notion of climate change altogether. This cultural condition has even created a difficult framework for the continuation of the initiative within the university itself. This paper also summarizes and speculates on the initiative as a unique pedagogical model for design-build studio and supporting technical and professional coursework. Students were exposed to many of the design challenges that we have come to expect from a design-build studio in terms of process, outcomes, and challenges. This does not diminish the student’s effort and embrace of the project. It does, however, bring attention to the positive effects that have been seen in the resulting curricular and service roles of the department and the recognition throughout the community. This is especially significant in a rural state with no residential energy code and negligible building code enforcement, suggesting issues that go beyond pedagogy and are measured against the region’s cultural and sociopolitical landscape.
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Segal, Dagan, Bo-Jui Chang, Hanieh Mazloom-Farsibaf, Reto Fiolka, James Amatruda i Gaudenz Danuser. "Abstract PHB01: The zebrafish as a mechanical filter: Using zebrafish xenografts to model Ewing sarcoma metastasis in vivo". W Abstracts: AACR Special Conference on the Evolving Landscape of Cancer Modeling; March 2-5, 2020; San Diego, CA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.camodels2020-phb01.

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Ibragimov, A. E., D. Yu Garshina, An Kh Baymiev i O. V. Lastochkina. "Modulation of Triticum aestivum L. tolerance to combined abiotic/biotic stresses by endophytic plant growth promoting bacteria Bacillus subtilis". W РАЦИОНАЛЬНОЕ ИСПОЛЬЗОВАНИЕ ПРИРОДНЫХ РЕСУРСОВ В АГРОЦЕНОЗАХ. Federal State Budget Scientific Institution “Research Institute of Agriculture of Crimea”, 2020. http://dx.doi.org/10.33952/2542-0720-15.05.2020.11.

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Wheat (Triticum aestivum L.) is one of the most important cereal food crops worldwide. Various abiotic and biotic stresses or their combinations lead to crop losses (up to 50-82%) and pose a serious threat to the agricultural industry and food security. Plant growth-promoting endophytic bacteria Bacillus subtilis are considered as a bioactive and eco-friendly strategy for plant protection. Earlier, we have shown B. subtilis 10-4 has a growth-promoting and anti-stress effect on wheat under water deficiency. Here, we investigated the effect of B. subtilis 10-4 and B. subtilis 10-4+salicylic acid (SA) on growth and tolerance of wheat (cv. ‘Omskaya-35’) to combined drought (12%PEG) and Fusarium culmorum. 12%PEG and F. culmorum led to yellowing of leaves (in addition to traces of the root damages). Inoculation with 10-4 and especially 10-4+SA reduced the fusarium development in wheat under drought. Similar effects were revealed for growth parameters. Also, 10-4 (especially 10-4+SA) reduces stress-induced lipid peroxidation (MDA). Such physiological effect may be connected with the ability of strain 10-4 to colonize the internal tissues of host-plant and regulate metabolism from the inside. The obtained construct based on the plasmid pHT01 and the green fluorescent protein (gfp) gene, by which was modified the strain 10-4, will allow revealing the nature of the symbiotic relationships between the strain 10-4 and host-plant. The findings indicate that application B. subtilis 10-4 and its composition with SA may be an effective strategy to increase wheat tolerance to the combined abiotic/biotic stresses.
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Raporty organizacyjne na temat "Phi01"

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Verderi, M. Measurements Related to the CKM Angle Beta/Phi1 from BABAR. Office of Scientific and Technical Information (OSTI), czerwiec 2004. http://dx.doi.org/10.2172/827314.

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