Rozprawy doktorskie na temat „Pharmacology”
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Riba, Serrano Jordi. "Human pharmacology of ayahuasca". Doctoral thesis, Universitat Autònoma de Barcelona, 2003. http://hdl.handle.net/10803/5378.
Pełny tekst źródłaAyahuasca is a psychotropic plant tea, obtained from Banisteriopsis caapi and Psychotria viridis, which has been used for centuries in the Amazon and Orinoco River Basins for magico-religious purposes and folk medicine. This tea contains alkaloids with monoamine-oxidase (MAO)-inhibiting properties (harmine, harmaline and tetrahydroharmine), together with a psychedelic compound (N,N-dimethyltryptamine or DMT), which is inactive per os in the absence of the first three. The use of ayahuasca has gradually spread to Europe since the early 1990s, and given the scarce information available on the effects of ayahuasca in humans, two clinical trials were conducted in healthy volunteers, who were administered various doses of encapsulated freeze-dried ayahuasca. In an initial pilot study, a placebo and three doses of ayahuasca equivalent to 0.50, 0.75 and 1.0 mg DMT/kg body weight were administered in increasing order to 6 healthy volunteers in single-blind conditions. In a subsequent study, a placebo and two doses of ayahuasca equivalent to 0.6 and 0.85 mg DMT/kg were administered to 18 healthy volunteers according to a double-blind randomized balanced design. The studied variables included measures of subjective and cardiovascular effects, pharmacokinetic parameters, urine neurotransmitter metabolites, electroencephalography recordings (EEG), evoked potentials (suppression of the auditive P50 potential) and electromyography (suppression of the startle reflex). Ayahuasca induced subjective feelings of increased activation, euphoria and well-being, modifications in somatic and visual perception, and also in thought content and speed. Peak subjective effects were observed between 60-120 minutes and were resolved by 4-6 hours. Cardiovascular effects were moderate, with statistically significant increases obtained only for diastolic blood pressure (9 mm Hg at 75 minutes after the 0.85 mg DMT/kg dose). The pharmacokinetic assessment revealed measurable plasma levels for DMT, harmaline and THH, but not for harmine. Levels of two O-demethylated compounds, i.e., harmol and harmalol, putative metabolites of harmine and harmaline, respectively, were detected in all volunteers. Cmax values for DMT after the low and the high ayahuasca doses were 12.14 ng/ml and 17.44 ng/ml, respectively. Tmax was observed at 90 minutes after both doses. Elimination half-life for DMT was 1 hour after both doses. DMT bioavailability in ayahuasca was estimated in 10-15%. Ayahuasca administration increased normetanephrine excretion, a COMT-dependent norepinephrine metabolite, and produced no change in the excretion of MAO-dependent metabolites. Regarding the EEG, decreases in absolute power were obtained for the delta, theta, alpha-2 and beta-1 bands. These decreases were maximal at 1-2 hours. The application of a source location technique to the topographical changes obtained, yielded intracerebral power density decreases in the temporo-parieto-occipital, frontomedial and temporomedial cortices. Finally, ayahuasca decreased suppression of the P50 potential (measuring sensory gating), but did not change prepulse inhibition of the startle reflex (measuring sensorimotor gating). The results obtained indicate for ayahuasca a pattern of psychedelic and stimulatory effects analogous to those reported by other authors for parentheral DMT, but with a lower intensity and a longer duration.
Cumming, Paul Kenneth. "Pharmacology of cerebral histamine". Thesis, University of British Columbia, 1990. http://hdl.handle.net/2429/30687.
Pełny tekst źródłaMedicine, Faculty of
Graduate
Karbwang, J. "Clinical pharmacology of mefloquine". Thesis, University of Liverpool, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.234865.
Pełny tekst źródłaOrdway, Gregory A. "Molecular Pharmacology of Antidepressants". Digital Commons @ East Tennessee State University, 2006. https://dc.etsu.edu/etsu-works/8657.
Pełny tekst źródłaLangford, Nigel James. "Beta-receptor pharmacology and therapeutics". Thesis, University of Birmingham, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.404060.
Pełny tekst źródłaHahn, Robert G. "Clinical pharmacology of infusion fluids". Linköpings universitet, Anestesiologi med intensivvård, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-91319.
Pełny tekst źródłaFarquhar, Michelle Jane. "Molecular pharmacology of chimeric peptides". Thesis, University of Wolverhampton, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.247780.
Pełny tekst źródłaPasanisi, F. "Clinical pharmacology of calcium antagonists". Thesis, University of Glasgow, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.381477.
Pełny tekst źródłaAl-Malki, Waleed Hassan. "Pharmacology of aqueous humour formation". Thesis, University of Glasgow, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.443403.
Pełny tekst źródłaWard, S. A. "The biochemical pharmacology of primaquine". Thesis, University of Liverpool, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.354530.
Pełny tekst źródłaMoss, Nicholas K. "TRPC channel activation and pharmacology". Thesis, University of Leeds, 2015. http://etheses.whiterose.ac.uk/9713/.
Pełny tekst źródłaAppleby, Hollie Leanne. "Orai channel physiology and pharmacology". Thesis, University of Leeds, 2016. http://etheses.whiterose.ac.uk/15950/.
Pełny tekst źródłaKeiser, Michael James. "Relating protein pharmacology by ligand chemistry". Diss., Search in ProQuest Dissertations & Theses. UC Only, 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3378494.
Pełny tekst źródłaSherwin, Catherine M. T., i n/a. "Clinical pharmacology of aminoglycosides in neonates". University of Otago. Dunedin School of Medicine, 2009. http://adt.otago.ac.nz./public/adt-NZDU20090821.160736.
Pełny tekst źródłaJonsson, Kent-Olov. "Pharmacology of Palmitoylethanolamide and Related Compounds". Doctoral thesis, Umeå : Dept. of pharmacology and clinical neuroscience, Univ, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-445.
Pełny tekst źródłaWells, Christine. "Hippopcampal function : theta, pharmacology and novelty". Thesis, University of Leeds, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.540763.
Pełny tekst źródłaBeckett, P. A. "Pharmacology of airway remodelling in asthma". Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.596514.
Pełny tekst źródłaHo, M. T. B. "Pharmacology of the orphan opioid receptor". Thesis, University of Cambridge, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.604104.
Pełny tekst źródłaBaker, Jillian G. "Molecular pharmacology of β-adrenoceptor ligands". Thesis, University of Nottingham, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.401579.
Pełny tekst źródłaLittle, Margaret. "The cellular pharmacology of thiopurine drugs". Thesis, University of Newcastle Upon Tyne, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.405347.
Pełny tekst źródłaBangchang, Kesara Na. "Clinical and biochemical pharmacology of mefloquine". Thesis, University of Liverpool, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.317200.
Pełny tekst źródłaRiviere, Judith Helen. "Biochemical and clinical pharmacology of Mefloquine". Thesis, University of Liverpool, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.328152.
Pełny tekst źródłaBailey, A. C. "Biochemistry and pharmacology of beta-bungarotoxin". Thesis, University of Essex, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.372585.
Pełny tekst źródłaAl-Zamil, Zeid Muhammed Zeid. "Pharmacology of isolated mammalian spinal cord". Thesis, University of Southampton, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.280402.
Pełny tekst źródłaBarkan, Kerry. "An investigation into glucagon receptor pharmacology". Thesis, University of Warwick, 2017. http://wrap.warwick.ac.uk/98781/.
Pełny tekst źródłaLewis, Clive Jonathan. "Pharmacology of the 'putative' Beta4-adrenoceptor". Thesis, University of Cambridge, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.615696.
Pełny tekst źródłaMartin, Richard John. "Veterinary pharmacology, ion-channels and anthelmintics". Thesis, University of Edinburgh, 1997. http://hdl.handle.net/1842/30450.
Pełny tekst źródłaAhtyamova, D. V. "Anti-aging pharmacology: promises and pitfalls". Thesis, Київський національний університет технологій та дизайну, 2018. https://er.knutd.edu.ua/handle/123456789/10636.
Pełny tekst źródłaNovozhilova, Ekaterina B. "Physiology and pharmacology of flatworm muscle". [Ames, Iowa : Iowa State University], 2008.
Znajdź pełny tekst źródłaSpratt, James Christopher Samuel. "Endothelin : cardiovascular pharmacology, physiology & pathophysiology". Thesis, University of Edinburgh, 2003. http://hdl.handle.net/1842/23202.
Pełny tekst źródłaWinstanley, Peter Andrew. "The pharmacology and toxicology of amodiaquine". Thesis, University of Liverpool, 1988. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.237571.
Pełny tekst źródłaNielsen, Carsten K. "Studies on the preclinical pharmacology of oxycodone /". St. Lucia, Qld, 2003. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe17560.pdf.
Pełny tekst źródłaYubero, Lahoz Samanta 1985. "MDMA pharmacology in humans and serotonergic effects". Doctoral thesis, Universitat Pompeu Fabra, 2013. http://hdl.handle.net/10803/145481.
Pełny tekst źródłaLa 3,4-metilendioximetanfetamina (MDMA, èxtasi) és una de les drogues més consumides al món. Aquesta droga inhibeix el seu propi metabolisme, inhibint un enzim polimòrfic del fetge, el CYP2D6, que és el responsable de l’eliminació d’una quarta part dels medicaments. Aquest fet té implicacions clíniques rellevants, ja que els consumidors de MDMA presenten una prevalença de psicopatologia més alta respecte a la població no consumidora, i moltes de la patologies psiquiàtriques es tracten amb fàrmacs substrats d’aquest enzim. A més, encara no s’ha discernit com aquesta droga pot ser eliminada de l’organisme, inclús després d’haver-ne consumit dosis de manera repetida. Així doncs, la primera part d’aquesta tesi es centra en estudiar l’autoinhibició de la MDMA determinant l’activitat de diferents enzims del fetge, en homes i dones. Encara que la farmacologia de la MDMA està descrita a fons, no està del tot clar quin és el seu mecanisme d’acció. La MDMA interactua amb el sistema serotonèrgic de diverses maneres, però avui en dia és molt difícil estudiar tècnicament el sistema serotonèrgic en el cervell humà. Les tècniques d’imatge estan limitades per molts factors, i per tant, seria molt útil tenir un índex perifèric a la sang de l’activitat serotonèrgica al sistema nerviós central. La segona part d’aquest tesi s’enfoca en el desenvolupament de tècniques per determinar a diferents nivells si el transportador de la serotonina a les plaquetes podria ser un bon biomarcador perifèric de la seva activitat al cervell, i d’aquesta manera veure si el sistema serotonèrgic està implicat en el mecanisme d’acció de la MDMA.
McGonigle, Ian Vincent. "Molecular pharmacology of an insect GABA receptor". Thesis, University of Cambridge, 2010. https://www.repository.cam.ac.uk/handle/1810/226857.
Pełny tekst źródłaBolton, John Francis. "Urinary tract smooth muscle physiology and pharmacology". Thesis, University of Bristol, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.432685.
Pełny tekst źródłaHand, C. W. "Studies on the human pharmacology of opiates". Thesis, University of Oxford, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.379946.
Pełny tekst źródłaMallon, Andrew Peter. "An investigation of NMDA receptor subunit pharmacology". Thesis, University of Glasgow, 2004. http://theses.gla.ac.uk/3127/.
Pełny tekst źródłaWhittaker, Steven Robert. "The molecular pharmacology of purine CDK inhibitors". Thesis, Institute of Cancer Research (University Of London), 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.404908.
Pełny tekst źródłaCroughton, Karen. "Novel pharmacology of the lipophilic antifolate methylbenzoprim". Thesis, University of Nottingham, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368236.
Pełny tekst źródłaRoberts, Claire. "5-HT terminal autoreceptor : pharmacology and function". Thesis, University of Nottingham, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.263094.
Pełny tekst źródłaBrown, Andrew M. G. "Biochemistry, tissue culture and pharmacology of Tanacetum". Thesis, University of Nottingham, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363563.
Pełny tekst źródłaKasorn, Anongnard. "The molecular pharmacology of lysophosphatidic acid receptors". Thesis, University of Nottingham, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.441003.
Pełny tekst źródłaAlyami, A. M. "Pharmacology of benzodiazepines and GABA in intestine". Thesis, University of Bradford, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.384251.
Pełny tekst źródłaBarnes, Matthew Joseph. "The cellular pharmacology of antifolates in leukaemia". Thesis, University of Newcastle Upon Tyne, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244470.
Pełny tekst źródłaYule, S. M. "The clinical pharmacology of cyclophosphamide in children". Thesis, University of Newcastle Upon Tyne, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.309831.
Pełny tekst źródłaPearson, Hugh Anthony. "Physiology and pharmacology of insect calcium channels". Thesis, University College London (University of London), 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.308295.
Pełny tekst źródłaMilton, Kevin Ashley. "The clinical and biochemical pharmacology of halofantrine". Thesis, University of Liverpool, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.291722.
Pełny tekst źródłaChoonara, I. A. "Clinical pharmacology of warfarin and vitamin K". Thesis, University of Liverpool, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.383440.
Pełny tekst źródłaClark, Kenneth Lyle. "Pharmacology of renal dopamine and angiotensin receptors". Thesis, Open University, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.293275.
Pełny tekst źródłaRidley, John Malcolm. "Pharmacology of the HERG K⺠channel". Thesis, University of Bristol, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.411068.
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