Rozprawy doktorskie na temat „Peptides Synthesis”
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Chen, Fei, i 陳飛. "Studies on aminoxy peptides and prebiotic peptide formation". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B38534149.
Pełny tekst źródłaSwenson, Helen Rachel. "Studies in synthetic peptides and heterocyclic synthesis". Thesis, University of Edinburgh, 1999. http://hdl.handle.net/1842/13061.
Pełny tekst źródłaDillon, David Lawrence. "Peptide derivatives as pharmaceuticals : synthesis and reactions of n-thioacyl peptides". Thesis, Oxford Brookes University, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.327912.
Pełny tekst źródłaLam, Hiu-yung, i 林曉勇. "Total synthesis of daptomycin and other cyclic peptides via Ser/Thr ligation-mediated peptide cyclization". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/207198.
Pełny tekst źródłapublished_or_final_version
Chemistry
Doctoral
Doctor of Philosophy
Corrihons, Fabien. "Solid phase peptide synthesis of cyclic peptides for cancer oncology". Thesis, University of Strathclyde, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.424312.
Pełny tekst źródłaNdung'u, Susan Wanjiru. "The medicinal chemistry of cyclo(D-Phe-2Cl-Pro) and cyclo(Phe-4F-Pro)". Thesis, Nelson Mandela Metropolitan University, 2011. http://hdl.handle.net/10948/7083.
Pełny tekst źródłaSieber, Stephan Axel. "Nonribosomal peptide synthetases quaternary structure and chemoenzymatic synthesis of macrocyclic peptides /". [S.l.] : [s.n.], 2004. http://archiv.ub.uni-marburg.de/diss/z2004/0218/.
Pełny tekst źródłaIrving, Stephen L. "Synthesis and purification of peptides". Thesis, University of Edinburgh, 1994. http://hdl.handle.net/1842/28282.
Pełny tekst źródłaAlexander, Mcmanamara Linda Mary. "Synthesis of stable - helical peptides". Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.398920.
Pełny tekst źródłaMartari, Marco. "Structure-function relationships of bolaamphiphilic peptides and peptide hybrids". Thesis, Link to the online version, 2006. http://hdl.handle.net/10019/582.
Pełny tekst źródłaRutt, Jason E. "The synthesis of marine cyclic peptides". Thesis, University of Nottingham, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.262984.
Pełny tekst źródłaTyszka, Joanna Helen Margaret. "Towards the synthesis of polycyclic peptides". Thesis, University of York, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.282302.
Pełny tekst źródłaBennett, Fiona Catherine. "Design and synthesis of model peptides". Thesis, King's College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299882.
Pełny tekst źródłaAhadi, Sara. "Ribosomal Synthesis of N-methylated peptides". VCU Scholars Compass, 2010. http://scholarscompass.vcu.edu/etd/134.
Pełny tekst źródłaHone, Neal. "The synthesis of atypical amino acids and peptides utilizing solid phase peptide synthesis and novel amine protection". Thesis, University of Nottingham, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.357925.
Pełny tekst źródłaTaylor, Tammye L. "UV photochemistry of synthetic model peptides". Thesis, Georgia Institute of Technology, 1994. http://hdl.handle.net/1853/26966.
Pełny tekst źródłaLobo, Ruiz Ariadna. "Pushing peptides further: Novel methodologies for the synthesis of backbone-modified peptides". Doctoral thesis, Universitat de Barcelona, 2019. http://hdl.handle.net/10803/667017.
Pełny tekst źródłaDadas sus propiedades intrínsecas y su atractivo perfil farmacológico, los péptidos y las proteínas, surgen como potenciales agentes terapéuticos para el descubrimiento de nuevos fármacos. No obstante, su explotación en este campo ha sido obstaculizada por su escasa estabilidad y biodisponibilidad. De especial interés, son las modificaciones en el esqueleto peptídico, ya que a menudo dan lugar a propiedades farmacológicas mejoradas, tales como una mayor estabilidad, biodisponibilidad, permeabilidad celular y una menor toxicidad. La presente tesis se centra en los depsipéptidos y péptidos grapa, que se encuentran entre las familias de péptidos más relevantes que presentan modificaciones en el esqueleto peptídico. En el primer proyecto, se desarrolló una metodología robusta en fase sólida, basada en la estrategia Fmoc, para la preparación de depsipéptidos que contienen enlaces éster múltiples y consecutivos. Para ello, un análogo sintético del ciclodepsipéptido natural YM-254890 se designó como modelo para estudiar los inconvenientes comúnmente encontrados en la síntesis de depsipéptidos en fase sólida, que a día de hoy, han obstaculizado la instauración de dicha metodología. Por consiguiente, dificultades como la formación de DKP, la eliminación problemática de Fmoc, la selección del esquema de grupos protectores, entre otras, fueron ampliamente estudiadas y resueltas. En el segundo proyecto, con el fin de inducir la conformación hélice alfa, a la vez que preparar compuestos con un perfil farmacológico mejorado, se abordó el diseño y desarrollo de una nueva clase de péptidos grapa altamente N-metilados, los denominados HMSP. Para ello, entre dos posiciones clave de la secuencia bioactiva del péptido p53, que naturalmente no presenta una estructura secundaria organizada, se introdujeron varios péptidos puente ricos en residuos N-metilo. La estructura hélice alfa fue inducida satisfactoriamente. Por otro lado, la inserción de dichos puentes dio lugar a la preparación de construcciones moleculares altamente versátiles, dado que la naturaleza, la longitud y la flexibilidad del puente pueden ser moduladas por el número y la naturaleza de los aminoácidos N-metilados.
Allen, William M. "Synthesis and characterization of novel phosphonopeptides /". Connect to online version, 1997. http://hdl.handle.net/1989/3742.
Pełny tekst źródłaStewart, A. S. J. "Organometallic derivatives of amino acids and peptides". Thesis, Robert Gordon University, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.376684.
Pełny tekst źródłaDeshmukh, Manjeet Vinayakrao. "Synthesis and characterization of mussel adhesive peptides". [S.l. : s.n.], 2005. http://archiv.ub.uni-marburg.de/diss/z2005/0111/.
Pełny tekst źródłaBrown, Angus R. "Solid phase synthesis of peptides and proteins". Thesis, University of Edinburgh, 1995. http://hdl.handle.net/1842/27313.
Pełny tekst źródłaCutts, Rosalind Jennifer. "Modelling, NMR and synthesis of food peptides". Thesis, University of Surrey, 1996. http://epubs.surrey.ac.uk/842985/.
Pełny tekst źródłaAndrews, Martin James Inglis. "Design and synthesis of conformationally stabilised peptides". Thesis, University College London (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.264663.
Pełny tekst źródłaZambrano, Raúl Horacio. "Synthesis and structural studies of prion peptides". Thesis, Massachusetts Institute of Technology, 1995. http://hdl.handle.net/1721.1/36652.
Pełny tekst źródłaJiang, Lu. "Chemical synthesis of peptides with biological importance". Thesis, University of Edinburgh, 1996. http://hdl.handle.net/1842/12302.
Pełny tekst źródłaAl-Wafi, Haider. "Synthesis and biological studies of cyclic peptides". Thesis, Cardiff University, 2018. http://orca.cf.ac.uk/114900/.
Pełny tekst źródłaFletcher, Matthew David. "Tailored peptides : the synthesis and conformational behaviour of partially modified retro-inverso peptides". Thesis, University of Bath, 1996. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.760695.
Pełny tekst źródłaKumari, P. "New methods for the conjugation of peptides". Thesis, University of Liverpool, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.279720.
Pełny tekst źródłaWong, Kim Kai Wai. "Synthesis of silicon functionalised cyclic peptides for enantiomeric separations". Thesis, University of Bath, 1990. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.278284.
Pełny tekst źródłaFindlay, Brandon. "Design and synthesis of cationic amphiphiles". American Society for Microbiology, 2010. http://hdl.handle.net/1993/21708.
Pełny tekst źródłaShi, Feng, i 石峰. "Synthesis, characterization and application of constrained 7/8 helix". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B44363229.
Pełny tekst źródłapublished_or_final_version
Chemistry
Doctoral
Doctor of Philosophy
Freeman, David J. "Synthetic and metal binding studies of cyclic peptides". Thesis, University of Nottingham, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299566.
Pełny tekst źródłaVaredian, Miranda. "Photoswitchable Peptidomimetics : Synthesis and Photomodulation of Functional Peptides". Doctoral thesis, Uppsala universitet, Institutionen för biokemi och organisk kemi, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9345.
Pełny tekst źródłaTegazzini, Diana. "Design, synthesis and activity evaluation of antioxidant peptides". Thesis, Queen's University Belfast, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.603073.
Pełny tekst źródłaCammish, Linda E. "The solid phase synthesis of arginine containing peptides". Thesis, University of Cambridge, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.328560.
Pełny tekst źródłaRoach, Peter L. "Synthesis of peptides by the solid phase method". Thesis, University of Edinburgh, 1990. http://hdl.handle.net/1842/14289.
Pełny tekst źródłaLear, Sam. "Total synthesis of bioactive peptides and whole proteins". Thesis, Durham University, 2016. http://etheses.dur.ac.uk/11946/.
Pełny tekst źródłaTamura, Takashi. "Synthesis and Biochemical Function of Selenocysteine-containing Peptides". Kyoto University, 1993. http://hdl.handle.net/2433/168917.
Pełny tekst źródłaKyoto University (京都大学)
0048
新制・課程博士
博士(農学)
甲第5495号
農博第775号
新制||農||660(附属図書館)
学位論文||H5||N2607(農学部図書室)
UT51-93-R23
京都大学大学院農学研究科農芸化学専攻
(主査)教授 左右田 健次, 教授 浅田 浩二, 教授 清水 昌
学位規則第4条第1項該当
Nowak, Cheryl L. "Design, synthesis, and evaluation of bicyclic peptides as ammonium ionophores". Link to electronic thesis, 2003. http://www.wpi.edu/Pubs/ETD/Available/etd-0428103-180827/.
Pełny tekst źródłaKeywords: solution 13C-NMR study; olid phase peptide synthesis; bicyclic peptides; ammonium ionophores; valinomycin; ion selective electrode. Includes bibliographical references (p. 63-65).
Foster, Michael Scott. "Design, synthesis, kinetic analysis, molecular modeling, and pharmacological evaluation of novel inhibitors of peptide amidation". Diss., Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/31816.
Pełny tekst źródłaCommittee Chair: Dr. Sheldon W. May; Committee Member: Dr. James C. Powers; Committee Member: Dr. Nicholas Hud; Committee Member: Dr. Niren Murthy; Committee Member: Dr. Stanley H. Pollock. Part of the SMARTech Electronic Thesis and Dissertation Collection.
Sasubilli, Ramakrishna Gutheil William G. "Solid-phase synthesis of peptides and peptide mimetics using urethane and backbone amide linker strategies". Diss., UMK access, 2006.
Znajdź pełny tekst źródła"A thesis in pharmaceutical sciences." Typescript. Advisor: William G. Gutheil. Vita. Title from "catalog record" of the print edition Description based on contents viewed Nov. 9, 2007. Includes bibliographical references (leaves 63-73). Online version of the print edition.
Umeobika, Ugochukwu Christian. "Solid phase peptide synthesis of substrates for the chemoenzymatic generation of cyanobactins analogues". Thesis, University of Aberdeen, 2017. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=233678.
Pełny tekst źródłaHao, Yu, i 郝宇. "Synthesis and conformational studies of beta 2,3-cyclic aminoxy peptides". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B36363236.
Pełny tekst źródłaCassidy, Peter Joseph. "The design and synthesis of peptide turn mimetics /". St. Lucia, Qld, 1998. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe16396.pdf.
Pełny tekst źródłaNg, Choi I.-teng Montserrat. "Solid-phase synthesis of 5-arylhistidine-containing peptides: from linear antimicrobial peptides to cyclic peptides derived from arylomycins and aciculitins". Doctoral thesis, Universitat de Girona, 2015. http://hdl.handle.net/10803/380739.
Pełny tekst źródłaLa incorporació de sistemes biarílics asimiètrics en seqüències peptídiques es considera un enfocament útil per a millorar l'activitat biològica de pèptids. Tenint en compte la dificultat d'arilar la posició 4 (5) de l'anell d'imidazole, aquesta tesi doctoral es centra en el desenvolupament de noves estratègies eficients per a la preparació en fase sòlida d'undecapèptids antimicrobians contenint una 5-arilhistidina a través d'una reacció de Suzuki-Miyaura sota irradiació microones. L'extensió d'aquesta metodologia ha permès la síntesi de pèptids biarílics cíclics de diferents mides que incorporen un enllaç His-Phe 0 His-Tyr. Posteriorment, s'ha desenvolupat un procediment per la síntesi total en fase sòlida de lipopèptids biarílics cíclics derivats de les arilomicines. Les estratègies anteriors s'han estès a la preparació de compostos biarílics anàlegs dels pèptids bicíclics marins aciculitines. Concretament, s'ha preparat anàlegs dels hemisferis nord i sud de las aciculitines així com pèptids biarílics bicíclics que incorporen un pont Phe-Phe, Phe-Tyr, Tyr-His 0 Tyr-Tyr.
Zerkout, Saïd. "Synthèse d'hydrazino peptides". Vandoeuvre-les-Nancy, INPL, 1994. http://www.theses.fr/1994INPL052N.
Pełny tekst źródłaGroussier, Marianne Francoise Andree. "A new orthogonal protecting-group strategy for lanthionine-containing peptides". Thesis, University College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325663.
Pełny tekst źródłaPavlov, Nikola. "Synthèse asymétrique d’analogues de β2-tryptophane et application en synthèse peptidique". Thesis, Montpellier 2, 2011. http://www.theses.fr/2011MON20186/document.
Pełny tekst źródłaTryptophan, an essential amino acid, both functions as a building block in protein biosynthesis and as a biochemical precursor. It is abundantly found in most biologically active peptides that exhibit various physiological properties in particular hormonal and antimicrobial activities. Some of its natural derivatives like serotonin, tryptamine, and also unnatural derivatives such as sumatriptan, have neurophysiologic effects. Tryptophan analogues are also important building blocks for the synthesis of peptidomimetics, natural products and biologically active compounds. Another important property of tryptophan and tryptophan analogues is related to the fluorescence of the indole ring that can be used to study conformational changes in protein and in protein-membrane interactions. The asymmetric Friedel-Crafts alkylation of various indoles with a chiral nitroacrylate provides optically active beta-tryptophan analogues after reduction of the nitro group and removal of the chiral auxiliary. This reaction generally occurs in good yield and high diastereoselectivity (up to 90:10). We have established a new route to prepare enantiopure beta-tryptophan analogues ((S)-2-indolyl-beta-alanines). We showed that beta-nitroacrylate (R)-2 is a good chiral auxiliary for asymmetric Friedel-Crafts alkylation of indoles. (R)-2-indolyl--alanines were obtained by the same synthetic route by using the chiral compound (S)-2. beta-tryptophan analogues are delivered in their N-Fmoc-protected form, ready to use for instance in solid phase peptide synthesis, which is one of the most popular method for peptide synthesis. This study provides a new example of asymmetric beta-tryptophan analogues preparation and further studies concerning their applications in medicinal chemistry and in organic synthesis are now in progress
Pahlke, Denis. "Synthesis, characterisation and sensor-functionalisation of transmembrane β-peptides". Doctoral thesis, Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2018. http://hdl.handle.net/21.11130/00-1735-0000-0003-C180-1.
Pełny tekst źródłaSeisel, Quentin. "Développement et vectorisation de peptides inhibiteurs du domaine PDZ de CAL pour le traitement de la mucoviscidose". Thesis, Montpellier, 2018. http://www.theses.fr/2018MONTT010/document.
Pełny tekst źródłaCystic fibrosis is a lethal disease induced by genetic mutations of the CFTR chloride channel, leading to a loss of its function in the epithelial tissues of various organs. The lung is particularly affected and becomes a target for chronical bacterial infections. To cure the disease, we developed so-called CFTR “stabilizers”, which are peptides inhibiting the interaction between the CFTR protein and the key mediator of its half-life at the apical membrane of epithelial cells, the CAL protein. In particular, the iCAL36 peptide showed an increase of the functionality of the mutated CFTR protein. The aim of this thesis was to increase this biological effect by improving its pharmacological parameters: cellular internalization (vectorization), metabolic stability and affinity for the CAL protein.The first axis of optimization was the internalization of the iCAL36 peptide by 7 different cell-penetrating peptides (CPP). The corresponding conjugates were evaluated upon their cytotoxicity, their uptake efficiency and their capacity to maintain this efficiency in the presence of proteases. The mechanism of entry of the two best candidates was then studied. Various bias frequently encountered during the analysis of CPP uptake efficiency by fluorescence methods were also identified and explained. Afterwards, the iCAL36 sequence was modulated by inclusion of non-natural amino acids. The screening of the peptide/protein interactions was performed by a method optimized during this thesis (PIPEPLUS process) and allowed the identification of 32 promising analogues of the iCAL36 sequence including several substitutions. In particular, one of these sequences (iCAL-Q27) showed an affinity 70 times stronger for the CAL protein compared to iCAL36, hinting a more complete inhibition of the CAL/CFTR interaction.Overall, these major results grant the access to second-generation “stabilizers” potentially showing an improved biological effect in the context of cystic fibrosis